VPS37A Gene
protein-coding GIFtS: 51
GCID: GC08P017149
|
|
vacuolar protein sorting 37 homolog A (S. cerevisiae)(Previous names: vacuolar protein sorting 37A (yeast), polyglutamine binding...)
(Previous symbol: PQBP2)
| |
Aliases
for VPS37A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vacuolar Protein Sorting 37 Homolog A (S. Cerevisiae)1 2 | | ESCRT-I Complex Subunit VPS37A2 3 | | HCRP11 2 3 5 | | FLJ326421 | | PQBP21 2 | | Vacuolar Protein Sorting 37A (Yeast)1 | | SPG531 2 | | Vacuolar Protein Sorting-Associated Protein 37A2 | | Polyglutamine Binding Protein 21 2 | | HVps37A1 | | Hepatocellular Carcinoma-Related Protein 12 3 | | |
Export aliases for VPS37A gene to outside databasesPrevious GC identifer: GC08P015649 |
Summaries
for VPS37A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VPS37A:
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required fortransport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesiclesof multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in thisgene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified onchromosome 5. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Dec 2012)
UniProtKB/Swiss-Prot: VP37A_HUMAN, Q8NEZ2Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation
|
Genomic Views
for VPS37A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VPS37A gene promoter:
POU2F2 (Oct-2.1) Oct-B1 RP58 oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for VPS37A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS37A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p22 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22VPS37A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P017149: view genomic region
(about GC identifiers)
Start:
|
17,104,080 bp from pter |
End:
|
17,159,936 bp from pter |
Size:
|
55,857 bases |
Orientation:
|
plus strand |
|
Proteins
for VPS37A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VP37A_HUMAN, Q8NEZ2 (See
protein sequence)Recommended Name: Vacuolar protein sorting-associated protein 37A Size: 397 amino acids; 44314 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists ofTSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101,VPS28 and HGS
Subcellular location: Late endosome membrane; Peripheral membrane protein. Nucleus
Sequence caution: Sequence=AAH22363.1; Type=Erroneous initiation;
Secondary accessions: Q336D5 Q6NW27 Q8N3D7 Q8TBL7 Q96DL9Alternative splicing: 3 isoforms: Q8NEZ2-1 Q8NEZ2-2 Q8NEZ2-3 Explore the universe of human proteins at neXtProt for VPS37A: NX_Q8NEZ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NEZ2
VPS37A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138624.1 NP_689628.2
ENSEMBL proteins: ENSP00000318629 ENSP00000429227 ENSP00000428823 ENSP00000430456 ENSP00000412824 ENSP00000429680 ENSP00000430933 ENSP00000429858 ENSP00000318173 Reactome Protein details: Q8NEZ2
Human Recombinant Protein Products for VPS37A:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
VPS37A for ontologies About GeneDecksing
VPS37A Antibody Products:
Assay Products for VPS37A: |
Protein
Domains /
Families
for VPS37A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VPS37A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NEZ2ProtoNet protein and cluster: Q8NEZ2 UniProtKB/Swiss-Prot: VP37A_HUMAN, Q8NEZ2Similarity: Belongs to the VPS37 familySimilarity: Contains 1 VPS37 C-terminal domain |
Function
for VPS37A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: VP37A_HUMAN, Q8NEZ2Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiationAnimal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37A (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): VPS37A (NM_001145152) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS37A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS37A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37A |
|
Pathways & Interactions
for VPS37A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signal Transduction | | | 2 | Late Phase of HIV Life Cycle | | | 3 | HIV Infection | | | 4 | Disease | | | 5 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for VPS37A (see all 9)
1 
Kegg Pathway (Kegg details for VPS37A):
VPS37A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS37A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/28 Interacting proteins for VPS37A (Q8NEZ23 ENSP000003186294) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
VPS37A for ontologies About GeneDecksing
|
Drugs & Compounds
for VPS37A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VPS37A
Search CenterWatch for drugs/clinical trials and news about VPS37A / VP37A
|
Transcripts
for VPS37A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VPS37A gene (2 alternative transcripts): NM_001145152.1 NM_152415.2 Unigene Cluster for VPS37A: Vacuolar protein sorting 37 homolog A (S. cerevisiae) Hs.343873 [show with all ESTs]Unigene Representative Sequence: NM_15241512 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000324849(uc003wxj.3 uc003wxk.3 uc003wxl.3) ENST00000519381
ENST00000520140 ENST00000518038 ENST00000425020 ENST00000521829 ENST00000521005
ENST00000521976 ENST00000521162 ENST00000520997 ENST00000519515 ENST00000324815
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37A (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): VPS37A (NM_001145152) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS37A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS37A |
Additional cDNA sequence: AF547097.1 AK057204.1 AK090607.1 AK124607.1 AY033079.2 BC022363.1 BC067754.1 14 DOTS entries: DT.437095 DT.444683 DT.100740206 DT.100025346 DT.102823889 DT.100025347 DT.121478414 DT.75109131 DT.97841453 DT.453547 DT.40265325 DT.95073963 DT.100828231 DT.121478465 24/223 AceView cDNA sequences (see all 223): AI915152 AA731894 AI401381 BG569425 BQ223872 AA570006 AI753690 BU739878 CD172484 AV708100 N69815 CK819669 BQ898849 AW137058 AY033079 BG569586 BF059571 BE671828 BF222701 Z45909 AL598624 BM728040 CR600138 AI167502
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for VPS37A (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | · | 1i | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for VPS37A
|
Expression
for VPS37A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VPS37A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTTTTAGC
About this image
See VPS37A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VPS37A
SOURCE GeneReport for Unigene cluster: Hs.343873
UniProtKB/Swiss-Prot: VP37A_HUMAN, Q8NEZ2Tissue specificity: Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidneyand pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas
SABiosciences Custom PCR Arrays for VPS37A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS37A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS37A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS37A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS37A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37A |
Orthologs
for VPS37A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for VPS37A gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Vps37a1 , 5 |
vacuolar protein sorting 37A (yeast)1, 5 |
89.08(n)1
90.68(a)1 |
|
8 (23.89 cM)5
523481 NM_033560.31 NP_291038.21
405117835 |
chicken
(Gallus gallus) |
Aves |
VPS37A1 |
vacuolar protein sorting 37 homolog A (S. cerevisiae) |
78.54(n)
81.68(a) |
|
422732 XM_420687.3 XP_420687.1 |
lizard
(Anolis carolinensis) |
Reptilia |
VPS37A6 |
-- |
82(a) |
1 ↔ 1 |
5(108243146-108252807) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.298022 |
Xenopus laevis transcribed sequences |
74.24(n) |
|
CB561052.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb08f032 |
wufb08f03 |
74.53(n) |
|
336368 BC059584.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mod(r)1 |
modifier of rudimentary |
38.96(n)
24.03(a) |
|
31006 NM_080295.2 NP_525034.2 |
ENSEMBL Gene Tree for VPS37A (if available)
TreeFam Gene Tree for VPS37A (if available) |
Paralogs
for VPS37A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VPS37A gene
- VPS37B2 VPS37C2 VPS37D2
5 SIMAP similar genes for VPS37A using alignment to 6 protein entries: VP37A_HUMAN (see all proteins):DOCK8 HDGFRP2 VPS37C VPS37B SEC14L3
VPS37A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for VPS37A
PGOHUM00000235815
|
Genomic Variants
for VPS37A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VPS37A (17104080 - 17159936 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VPS37A: --
Human Gene Mutation Database (HGMD): VPS37A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS37A |
|
Disorders
/ Diseases
for VPS37A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VPS37A for disorders About GeneDecksing
OMIM gene information: 609927
OMIM disorders: --
UniProtKB/Swiss-Prot: VP37A_HUMAN, Q8NEZ2
Note=Defects in VPS37A are a cause of autosomal recessive complex hereditary spastic paraparesis, acomplicated form of hereditary spastic paraplegia (HSP). HSP is a heterogeneous group of neurodegenerative disorderscharacterized by progressive lower limb spasticity, retrograde degeneration of the crossed cortico-spinal tracts andthinning of the posterior columns in the spinal cord. Complicated forms are characterized by the addition of suchneurological features as spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebralor cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations suchas dysmorphism, albinism, retinitis pigmentosa, deafness, dementia, amyotrophy and ichthyosis. Individuals with VPS37Amutations present with pronounced early onset spastic paraparesis of upper and lower limbs, mild intellectualdisability, kyphosis, pectus carinatum and hypertrichosis
11  diseases for VPS37A: About MalaCardshepatocellular carcinoma carcinoma hypertrichosis pectus carinatum
spastic paraparesis hereditary spastic paraplegia spasticity spastic paraplegia
retinitis pigmentosa optic atrophy paraplegia
1 disease from the University of Copenhagen DISEASES database for VPS37A:Hypertrichosis Export disorders for VPS37A gene to outside databases
|
Publications
for VPS37A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VPS37A gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with VPS37A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis. (PubMed id 22717650)1, 2, 3 Zivony-Elboum Y.... Falik-Zaccai T.C. (2012)
- The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PubMed id 15218037)1, 2, 3 Stuchell M.D....Sundquist W.I. (2004)
- The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. (PubMed id 15240819)1, 2, 3 Bache K.G....Stenmark H. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein. (PubMed id 14623289)1, 2 Xu Z.... Zhao M. (2003)
- The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PubMed id 22405001)1 Agromayor M....Williams R.L. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- hVps37A Status affects prognosis and cetuximab sensiti vity in ovarian cancer. (PubMed id 22016507)1 Wittinger M....Krainer M. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for VPS37A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VPS37A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VPS37A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VPS37A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for VPS37A gene:
Search GeneIP for patents involving VPS37A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for VPS37A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS37A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS37A | | | OriGene Protein Over-expression Lysate for VPS37A | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for VPS37A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS37A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VPS37A | | OriGene Custom Protein Services for VPS37A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VPS37A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS37A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS37A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS37A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS37A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS37A |
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| | | | Search Tocris compounds for VPS37A |
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 | | | VPS37A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS37A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for VPS37A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS37A |
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