Aliases for VPS37A Gene
External Ids for VPS37A Gene
Previous HGNC Symbols for VPS37A Gene
Previous GeneCards Identifiers for VPS37A Gene
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
GeneCards Summary for VPS37A Gene
VPS37A (VPS37A, ESCRT-I Subunit) is a Protein Coding gene. Diseases associated with VPS37A include Spastic Paraplegia 53, Autosomal Recessive and Spastic Paraplegia 53. Among its related pathways are Infectious disease and HIV Life Cycle. An important paralog of this gene is VPS37C.
UniProtKB/Swiss-Prot for VPS37A Gene
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.