Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VPS37A Gene

Aliases for VPS37A Gene

  • Vacuolar Protein Sorting 37 Homolog A (S. Cerevisiae) 2 3
  • HCRP1 3 4 6
  • Hepatocellular Carcinoma-Related Protein 1 3 4
  • Polyglutamine Binding Protein 2 2 3
  • ESCRT-I Complex Subunit VPS37A 3 4
  • SPG53 3 6
  • Vacuolar Protein Sorting-Associated Protein 37A 3
  • Hepatocellular Carcinoma Related Protein 1 2
  • Vacuolar Protein Sorting 37A (Yeast) 2
  • HVps37A 4
  • PQBP2 3

External Ids for VPS37A Gene

Previous HGNC Symbols for VPS37A Gene

  • PQBP2

Previous GeneCards Identifiers for VPS37A Gene

  • GC08P017149
  • GC08P015649

Summaries for VPS37A Gene

Entrez Gene Summary for VPS37A Gene

  • This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for VPS37A Gene

VPS37A (Vacuolar Protein Sorting 37 Homolog A (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with VPS37A include spastic paraplegia 53, autosomal recessive and hepatocellular carcinoma. Among its related pathways are Disease and Endocytosis. An important paralog of this gene is VPS37B.

UniProtKB/Swiss-Prot for VPS37A Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS37A Gene

Genomics for VPS37A Gene

Regulatory Elements for VPS37A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VPS37A Gene

Start:
17,246,571 bp from pter
End:
17,302,427 bp from pter
Size:
55,857 bases
Orientation:
Plus strand

Genomic View for VPS37A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS37A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS37A Gene

Proteins for VPS37A Gene

  • Protein details for VPS37A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEZ2-VP37A_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 37A
    Protein Accession:
    Q8NEZ2
    Secondary Accessions:
    • Q336D5
    • Q6NW27
    • Q8N3D7
    • Q8TBL7
    • Q96DL9

    Protein attributes for VPS37A Gene

    Size:
    397 amino acids
    Molecular mass:
    44314 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28 and HGS. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry.
    SequenceCaution:
    • Sequence=AAH22363.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for VPS37A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS37A Gene

Proteomics data for VPS37A Gene at MOPED

Post-translational modifications for VPS37A Gene

  • Ubiquitination at Lys29
  • Modification sites at PhosphoSitePlus

Other Protein References for VPS37A Gene

No data available for DME Specific Peptides for VPS37A Gene

Domains for VPS37A Gene

Protein Domains for VPS37A Gene

Suggested Antigen Peptide Sequences for VPS37A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEZ2

UniProtKB/Swiss-Prot:

VP37A_HUMAN :
  • Q8NEZ2
Domain:
  • Contains 1 VPS37 C-terminal domain.
Family:
  • Belongs to the VPS37 family.
genes like me logo Genes that share domains with VPS37A: view

No data available for Gene Families for VPS37A Gene

Function for VPS37A Gene

Molecular function for VPS37A Gene

UniProtKB/Swiss-Prot Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Gene Ontology (GO) - Molecular Function for VPS37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with VPS37A: view

Animal Model Products

CRISPR Products

miRNA for VPS37A Gene

miRTarBase miRNAs that target VPS37A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS37A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS37A Gene

Localization for VPS37A Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS37A Gene

Late endosome membrane; Peripheral membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS37A Gene COMPARTMENTS Subcellular localization image for VPS37A gene
Compartment Confidence
endosome 5
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for VPS37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex IDA 18005716
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with VPS37A: view

Pathways for VPS37A Gene

genes like me logo Genes that share pathways with VPS37A: view

Pathways by source for VPS37A Gene

1 KEGG pathway for VPS37A Gene

Gene Ontology (GO) - Biological Process for VPS37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008219 cell death --
GO:0015031 protein transport IEA --
GO:0016032 viral process TAS --
GO:0016197 endosomal transport TAS --
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with VPS37A: view

Transcripts for VPS37A Gene

Unigene Clusters for VPS37A Gene

Vacuolar protein sorting 37 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS37A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS37A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - - -
SP11:
SP12: - - - - - - - - - - -
SP13: - - -

ExUns: 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d
SP1: - -
SP2: - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for VPS37A Gene

GeneLoc Exon Structure for
VPS37A
ECgene alternative splicing isoforms for
VPS37A

Expression for VPS37A Gene

mRNA expression in normal human tissues for VPS37A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS37A Gene

SOURCE GeneReport for Unigene cluster for VPS37A Gene Hs.343873

mRNA Expression by UniProt/SwissProt for VPS37A Gene

Q8NEZ2-VP37A_HUMAN
Tissue specificity: Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.
genes like me logo Genes that share expressions with VPS37A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VPS37A Gene

Orthologs for VPS37A Gene

This gene was present in the common ancestor of animals.

Orthologs for VPS37A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS37A 35
  • 99.66 (n)
  • 99.75 (a)
VPS37A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS37A 35
  • 93.45 (n)
  • 94.46 (a)
VPS37A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS37A 35
  • 91.92 (n)
  • 92.93 (a)
VPS37A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps37a 35
  • 89.08 (n)
  • 90.68 (a)
Vps37a 16
Vps37a 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS37A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS37A 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps37a 35
  • 88.92 (n)
  • 90.93 (a)
chicken
(Gallus gallus)
Aves VPS37A 35
  • 77.58 (n)
  • 79.95 (a)
VPS37A 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS37A 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29802 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6793 35
vps37a 35
  • 69.37 (n)
  • 70.16 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13062 35
zebrafish
(Danio rerio)
Actinopterygii vps37a 35
  • 64.25 (n)
  • 64.77 (a)
vps37a 36
  • 65 (a)
OneToOne
wufb08f03 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002538 35
  • 42.21 (n)
  • 32.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1115 36
  • 19 (a)
OneToMany
mod(r) 35
  • 38.96 (n)
  • 24.03 (a)
worm
(Caenorhabditis elegans)
Secernentea vps-37 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10674 36
  • 20 (a)
OneToMany
Species with no ortholog for VPS37A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS37A Gene

ENSEMBL:
Gene Tree for VPS37A (if available)
TreeFam:
Gene Tree for VPS37A (if available)

Paralogs for VPS37A Gene

Paralogs for VPS37A Gene

Selected SIMAP similar genes for VPS37A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for VPS37A Gene

genes like me logo Genes that share paralogs with VPS37A: view

Variants for VPS37A Gene

Sequence variations from dbSNP and Humsavar for VPS37A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs8276 -- 17,295,348(+) ATTTC(G/T)TTATC utr-variant-3-prime
rs739335 -- 17,250,952(+) CTTCT(A/C)AGTAT intron-variant
rs756602 -- 17,250,513(+) GTTTC(A/G)TTTTA intron-variant
rs1012340 -- 17,276,059(+) CTTTT(C/G)TATAT intron-variant
rs1029335 -- 17,249,539(+) AATTC(C/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS37A Gene

Variant ID Type Subtype PubMed ID
nsv831244 CNV Gain 17160897
nsv831245 CNV Gain 17160897
nsv890556 CNV Loss 21882294
nsv518761 CNV Loss 19592680

Relevant External Links for VPS37A Gene

HapMap Linkage Disequilibrium report
VPS37A
Human Gene Mutation Database (HGMD)
VPS37A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS37A Gene

Disorders for VPS37A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for VPS37A Gene including...

Search for VPS37A Gene in MalaCards »

(1) OMIM Diseases for VPS37A Gene (609927)

UniProtKB/Swiss-Prot

VP37A_HUMAN
  • Spastic paraplegia 53, autosomal recessive (SPG53) [MIM:614898]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. SPG53 is characterized by pronounced early onset spastic paraparesis of upper and lower limbs, mild intellectual disability, kyphosis, pectus carinatum and hypertrichosis. {ECO:0000269 PubMed:22717650}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for VPS37A Gene

Relevant External Links for VPS37A

Genetic Association Database (GAD)
VPS37A
genes like me logo Genes that share disorders with VPS37A: view

Publications for VPS37A Gene

  1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PMID: 15218037) Stuchell M.D. … Sundquist W.I. (J. Biol. Chem. 2004) 2 3 4
  2. The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. (PMID: 15240819) Bache K.G. … Stenmark H. (Mol. Biol. Cell 2004) 2 3 4
  3. A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis. (PMID: 22717650) Zivony-Elboum Y. … Falik-Zaccai T.C. (J. Med. Genet. 2012) 2 3 4
  4. HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein. (PMID: 14623289) Xu Z. … Zhao M. (Biochem. Biophys. Res. Commun. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for VPS37A Gene

Sources for VPS37A Gene

Back to Top

Content