Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS36 Gene

protein-coding   GIFtS: 51
GCID: GC13M052986

Vacuolar Protein Sorting 36 Homolog (S. Cerevisiae)

(Previous names: chromosome 13 open reading frame 9, vacuolar protein sorting...)
(Previous symbol: C13orf9)
Microbiology & Infectious Diseases Congress
  Search for VPS36
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vacuolar Protein Sorting 36 Homolog (S. Cerevisiae)1 2     ESCRT-II Complex Subunit VPS362 3
C13orf91 2 3     Chromosome 13 Open Reading Frame 91
EAP452 3 5     Vacuolar Protein Sorting 36 Homolog (Yeast)1
ELL-Associated Protein Of 45 KDa2 3     Vacuolar Protein-Sorting-Associated Protein 362

External Ids:    HGNC: 203121   Entrez Gene: 510282   Ensembl: ENSG000001361007   OMIM: 6109035   UniProtKB: Q86VN13   

Export aliases for VPS36 gene to outside databases

Previous GC identifers: GC13M051885 GC13M033725


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPS36 Gene:
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II
(ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A
similar protein complex in rat is associated with RNA polymerase elongation factor II. (provided by RefSeq, Aug
2013)

GeneCards Summary for VPS36 Gene: 
VPS36 (vacuolar protein sorting 36 homolog (S. cerevisiae)) is a protein-coding gene. Among its related super-pathways are Budding and maturation of HIV virion and Translocation of GLUT4 to the Plasma Membrane. GO annotations related to this gene include ubiquitin binding and phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot: VPS36_HUMAN, Q86VN1
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is
required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB
pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II
complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably
plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may
also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such
as PtdIns(3,4,5)P3

Gene Wiki entry for VPS36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS36 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   CBF-C   Nkx3-1 v2   CBF-B   CBF-A   Nkx3-1 v3   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS36 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.13

VPS36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS36 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M052986:  view genomic region     (about GC identifiers)

Start:
52,986,737 bp from pter      End:
53,024,763 bp from pter
Size:
38,027 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VPS36_HUMAN, Q86VN1 (See protein sequence)
Recommended Name: Vacuolar protein-sorting-associated protein 36  
Size: 386 amino acids; 43817 Da
Subunit: Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity).
Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and two
copies of VPS25. Interacts with VPS25, SNF8, TSG101 and VPS36. Interacts (via GLUE domain) with ubiquitin.
Interacts with RILPL1 (via the C-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts
with ECM29
Subcellular location: Cytoplasm. Endosome. Late endosome. Membrane. Nucleus (Probable). Note=Colocalizes with
ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation
Sequence caution: Sequence=BAB14451.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for VPS36:
2HTH (3D)        2ZME (3D)        3CUQ (3D)    
Secondary accessions: A8K125 Q3ZCV7 Q5H9S1 Q5VXB6 Q9H8Z5 Q9Y3E3
Alternative splicing: 2 isoforms:  Q86VN1-1   Q86VN1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPS36: NX_Q86VN1

Explore proteomics data for VPS36 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VN1

  • VPS36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VPS36 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269097.1  NP_001269098.1  NP_057159.2  

    ENSEMBL proteins: 
     ENSP00000367299  
    Reactome Protein details: Q86VN1
    Human Recombinant Protein Products for VPS36: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VPS36
    OriGene Protein Over-expression Lysate for VPS36
    OriGene MassSpec for VPS36 
    OriGene Custom Protein Services for VPS36
    GenScript Custom Purified and Recombinant Proteins Services for VPS36
    Novus Biologicals VPS36 Protein
    Novus Biologicals VPS36 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VPS36 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005764lysosome IEA--
    GO:0005768endosome IDA--
    GO:0005770late endosome IEA--
    GO:0005829cytosol TAS--

    VPS36 for ontologies           About GeneDecksing



    VPS36 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for VPS36
    GenScript Custom Superior Antibodies Services for VPS36
    Novus Biologicals VPS36 Antibodies
    Abcam antibodies for VPS36
    Cloud-Clone Corp. Antibodies for VPS36 
    ThermoFisher Antibodies for VPS36
    Search LSBio for Antibodies for VPS36 

    Assay Products for VPS36: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VPS36
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VPS36
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VPS36 
    Cloud-Clone Corp. CLIAs for VPS36


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR007286 EAP30
     IPR021648 VPS36_GLUE

    Graphical View of Domain Structure for InterPro Entry Q86VN1

    ProtoNet protein and cluster: Q86VN1

    UniProtKB/Swiss-Prot: VPS36_HUMAN, Q86VN1
    Domain: The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates the binding to ubiquitin and
    phosphoinosides
    Similarity: Belongs to the VPS36 family
    Similarity: Contains 1 GLUE C-terminal domain
    Similarity: Contains 1 GLUE N-terminal domain


    VPS36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS36_HUMAN, Q86VN1
    Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is
    required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB
    pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II
    complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably
    plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may
    also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such
    as PtdIns(3,4,5)P3

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032266phosphatidylinositol-3-phosphate binding IEA--
    GO:0043130ubiquitin binding IEA--
         
    VPS36 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for VPS36 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VPS36

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS36 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS36 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS36
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS36 (see all 33):
    hsa-miR-607 hsa-miR-29a hsa-miR-507 hsa-miR-570 hsa-miR-4325 hsa-miR-3690 hsa-miR-365 hsa-miR-320d
    SwitchGear 3'UTR luciferase reporter plasmidVPS36 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VPS36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS36

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VPS36
    Sirion Biotech Customized adenovirus for overexpression of VPS36

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for VPS36 (see all 7)
    OriGene ORF clones in mouse, rat for VPS36
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VPS36 (NM_016075)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS36
    Sirion Biotech Customized lentivirus for stable overexpression of VPS36 
                         Customized lentivirus expression plasmids for stable overexpression of VPS36 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VPS36
    Search LifeMap BioReagents cell lines for VPS36
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS36


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VPS36 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endosomal Sorting Complex Required For Transport (ESCRT)
    Endosomal Sorting Complex Required For Transport (ESCRT)0.71
    2Membrane Trafficking
    Membrane Trafficking0.32
    3Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for VPS36
        Membrane Trafficking
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1         Kegg Pathway  (Kegg details for VPS36):
        Endocytosis


    VPS36 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/584 Interacting proteins for VPS36 (Q86VN12, 3 ENSP000003672994) via UniProtKB, MINT, STRING, and/or I2D (see all 584)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998162, 3, ENSP000002519684MINT-7947479 I2D: score=2 STRING: ENSP00000251968
    SNF8Q96H203, ENSP000002903304I2D: score=3 STRING: ENSP00000290330
    VPS25Q9BRG13, ENSP000002537944I2D: score=5 STRING: ENSP00000253794
    CHMP6Q96FZ73, ENSP000003174684I2D: score=2 STRING: ENSP00000317468
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0015031protein transport IEA--
    GO:0016197endosomal transport TAS--

    VPS36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS36

    Search CenterWatch for drugs/clinical trials and news about VPS36

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPS36 gene (3 alternative transcripts): 
    NM_001282168.1  NM_001282169.1  NM_016075.3  

    Unigene Cluster for VPS36:

    Vacuolar protein sorting 36 homolog (S. cerevisiae)
    Hs.109520  [show with all ESTs]
    Unigene Representative Sequence: AB208956
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378060(uc001vgq.3 uc001vgs.3) ENST00000497149 ENST00000462289
    ENST00000492650 ENST00000480923 ENST00000475375
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS36
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS36 (see all 33):
    hsa-miR-607 hsa-miR-29a hsa-miR-507 hsa-miR-570 hsa-miR-4325 hsa-miR-3690 hsa-miR-365 hsa-miR-320d
    SwitchGear 3'UTR luciferase reporter plasmidVPS36 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VPS36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS36
    Clone
    Products:
         
    OriGene clones in human, mouse for VPS36 (see all 7)
    OriGene ORF clones in mouse, rat for VPS36
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VPS36 (NM_016075)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS36
    Sirion Biotech Customized lentivirus for stable overexpression of VPS36 
                         Customized lentivirus expression plasmids for stable overexpression of VPS36 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VPS36
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS36
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS36
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS36
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS36

    Additional mRNA sequence: 

    AB208956.1 AF151903.1 AK022911.1 AK023182.1 AK094335.1 AK289740.1 BC037279.1 BC050439.1 
    BX647847.1 CR933653.1 

    14 DOTS entries:

    DT.100780812  DT.97787411  DT.448344  DT.304780  DT.95269296  DT.120790635  DT.100780810  DT.91708731 
    DT.95269294  DT.95365539  DT.86858579  DT.95269291  DT.95320447  DT.75172189 

    24/314 AceView cDNA sequences (see all 314):

    CA944508 AU131499 AI554215 BG982544 BM674913 BU737349 AI565139 AA905651 
    BM711180 AI146819 BM709965 BQ029526 CR597536 CK818951 AI038557 BM972213 
    BQ023963 AA194849 BM977930 BF060715 AI208829 CR590821 CR616305 AA778396 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VPS36    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:              -     -                       -                                                                 -               
    SP2:                    -                       -                                                                 -               
    SP3:                    -                                                                                                         
    SP4:                                            -                                                                                 
    SP5:                                                                    -     -     -                 -                           


    ECgene alternative splicing isoforms for VPS36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTATTCT
    VPS36 Expression
    About this image


    See VPS36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS36

    SOURCE GeneReport for Unigene cluster: Hs.109520
        SABiosciences Custom PCR Arrays for VPS36
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VPS36
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS36
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS36
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS36
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS36
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS36 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps361 , 5 vacuolar protein sorting 36 (yeast)1, 5 90.33(n)1
    95.85(a)1
      8 (11.14 cM)5
    701601  NM_027338.11  NP_081614.11 
     221928095 
    chicken
    (Gallus gallus)
    Aves VPS361 vacuolar protein sorting 36 homolog (S. cerevisiae) 80.57(n)
    89.64(a)
      418883  XM_417077.3  XP_417077.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS366
    Uncharacterized protein
    90(a)
    1 ↔ 1
    1(132683714-132711787)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.137682 Transcribed sequence with moderate similarity to protein more 78.34(n)    BX737003.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj33d072 wufj33d07 74.88(n)   335810  BC045509.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps361 Vacuolar protein sorting 36 54.3(n)
    47.37(a)
      39523  NM_140403.1  NP_648660.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-361 Protein VPS-36 51.32(n)
    43.39(a)
      179520  NM_073397.4  NP_505798.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G049201 vacuolar protein sorting-associated protein 36 48.36(n)
    41.26(a)
      830374  NM_120574.4  NP_196112.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g08135001 hypothetical protein 48.94(n)
    41.72(a)
      4327592  NM_001051135.1  NP_001044600.1 


    ENSEMBL Gene Tree for VPS36 (if available)
    TreeFam Gene Tree for VPS36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/795 SNPs in VPS36 are shown (see all 795)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159973551,2
    C,F--52986281(+) TGATGC/TAGGCA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1390397601,2
    --52986325(+) GTGGGC/TGTGGG 1 -- int10--------
    rs1833977411,2
    --52986627(+) GCTTAC/TATGTC 1 -- int10--------
    rs1876921021,2
    --52986628(+) CTTACA/GTGTCT 1 -- int10--------
    rs1430497581,2
    --52986643(+) CCCCAA/GCTAGG 1 -- int10--------
    rs1470332241,2
    C--52986652(+) GGTTTC/TCCTTT 1 -- int10--------
    rs1385776491,2
    C--52986671(+) ACACAC/GCTGTA 1 -- int10--------
    rs2022182301,2
    C--52986759(+) AAATG-/TTTTTT 1 -- ut310--------
    rs1925078411,2
    C--52986884(+) GCCCTA/GTTCTC 1 -- ut310--------
    rs1126971161,2
    F--52986899(+) CTTAGC/AATACA 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for VPS36 (52986737 - 53024763 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VPS36:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428288CNV Loss18775914
    dgv1588n71CNV Loss21882294
    nsv900084CNV Gain21882294
    nsv7242OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS36
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VPS36 for disorders           About MalaCards
    OMIM gene information: 610903    OMIM disorders: --


    VPS36 for disorders           About GeneDecksing


    Export disorders for VPS36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS36 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with VPS36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide- interacting GLUE domain. (PubMed id 15755741)1, 2, 3 Slagsvold T.... Stenmark H. (2005)
    2. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (2010)
    3. Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. (PubMed id 18539118)1, 2 Im Y.J. and Hurley J.H. (2008)
    4. Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. (PubMed id 17057716)1, 2 Alam S.L....Sundquist W.I. (2006)
    5. RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. (PubMed id 17010938)1, 2 Wang T. and Hong W. (2006)
    6. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. (PubMed id 16973552)1, 2 Langelier C.... Sundquist W.I. (2006)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51028 HGNC: 20312 AceView: C13orf9andTHSD1 Ensembl:ENSG00000136100 euGenes: HUgn51028
    ECgene: VPS36 Kegg: 51028 H-InvDB: VPS36

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPS36 gene:
    Search GeneIP for patents involving VPS36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for VPS36  
     OriGene qPCR primer pairs and template standards for VPS36   OriGene Protein Over-expression Lysate for VPS36  
     OriGene MassSpec something-or-other for VPS36   OriGene clones in human, mouse for VPS36  
     OriGene qSTAR qPCR primer pairs in human, mouse for VPS36   OriGene Purified Protein for VPS36  
     OriGene ORF clones in mouse, rat for VPS36   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VPS36   OriGene Custom Protein Services for VPS36  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VPS36
     QIAGEN SeqTarget long-range PCR primers for resequencing VPS36
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS36
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS36
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS36
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS36
     GenScript Custom Purified and Recombinant Proteins Services for VPS36 GenScript cDNA clones with any tag delivered in your preferred vector for VPS36
     GenScript Custom Assay Services for VPS36 GenScript Custom Superior Antibodies Services for VPS36
     GenScript Custom overexpressing Cell Line Services for VPS36 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in VPS36 promoter
     Search Chromatin IP Primers for VPS36
     RT2 qPCR Primer Assay in human, mouse, rat VPS36
     GNC Network for VPS36
     SABiosciences Custom PCR Arrays for VPS36
     Search Tocris compounds for VPS36
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     VPS36 antibodies
     VPS36 proteins
     VPS36 lysates
     Antibodies for VPS36
     See all of Abcam's Antibodies, Kits and Proteins for VPS36
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for VPS36
     Antibodies for VPS36
     ELISAs for VPS36
     CLIAs for VPS36
     Search LifeMap BioReagents cell lines for VPS36
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS36
     SwitchGear 3'UTR luciferase reporter plasmids for VPS36
     SwitchGear Promoter luciferase reporter plasmids for VPS36
     ThermoFisher Antibodies for VPS36
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS36
     inGenious Targeting Laboratory - Custom generated mouse model solutions for VPS36
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VPS36
    Customized:
     lentivirus for stable overexpression of VPS36
     lentivirus expression plasmids for stable overexpression of VPS36
     adenovirus for overexpression of VPS36
     Search LSBio for Antibodies for VPS36
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VPS36 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4