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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS36 Gene

protein-coding   GIFtS: 51
GCID: GC13M052986

vacuolar protein sorting 36 homolog (S. cerevisiae)

(Previous names: chromosome 13 open reading frame 9, vacuolar protein sorting...)
(Previous symbol: C13orf9)
 Explore 1 disease affiliated with
VPS36 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VPS36    

Aliases
for VPS36 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vacuolar Protein Sorting 36 Homolog (S. Cerevisiae)1 2     Eap451
C13orf91 2 3     Chromosome 13 Open Reading Frame 91
EAP452 3 5     Vacuolar Protein Sorting 36 Homolog (Yeast)1
ELL-Associated Protein Of 45 KDa2 3     ELL-Associated Protein, 45 KDa2
ESCRT-II Complex Subunit VPS362 3     Vacuolar Protein-Sorting-Associated Protein 362
CGI-1451     

External Ids:    HGNC: 203121   Entrez Gene: 510282   Ensembl: ENSG000001361007   OMIM: 6109035   UniProtKB: Q86VN13   

Export aliases for VPS36 gene to outside databases

Previous GC identifers: GC13M051885 GC13M033725


Summaries
for VPS36 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VPS36:
VPS36, VPS22 (SNF8; MIM 610904), and VPS25 (MIM 610907) form ESCRT-II (endosomal sorting complex required for transport
II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS36, VPS22, and VPS25 are also associated
in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 (PubMed
15755741); Kamura et al., 2001 (PubMed 11278625)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: VPS36_HUMAN, Q86VN1
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required
for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates
delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably
involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal
sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription
regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3

Gene Wiki entry for VPS36


Genomic Views
for VPS36 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS36 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   CBF-C   Nkx3-1 v2   CBF-B   CBF-A   Nkx3-1 v3   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VPS36 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.13

VPS36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS36 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M052986:  view genomic region     (about GC identifiers)

Start:
 52,986,737 bp from pter      End:
 53,024,763 bp from pter
Size:
 38,027 bases      Orientation:
 minus strand

Proteins
for VPS36 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VPS36_HUMAN, Q86VN1 (See protein sequence)
Recommended Name: Vacuolar protein-sorting-associated protein 36  
Size: 386 amino acids; 43817 Da
Subunit: Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity).
Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and two
copies of VPS25. Interacts with VPS25, SNF8, TSG101 and VPS36. Interacts (via GLUE domain) with ubiquitin. Interacts
with RILPL1 (via the C-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts with ECM29
Subcellular location: Cytoplasm. Endosome. Late endosome. Membrane. Nucleus (Probable). Note=Colocalizes with
ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation
Sequence caution: Sequence=BAB14451.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for VPS36:
2HTH (3D)        2ZME (3D)        3CUQ (3D)    
Secondary accessions: A8K125 Q3ZCV7 Q5H9S1 Q5VXB6 Q9H8Z5 Q9Y3E3
Alternative splicing: 2 isoforms:  Q86VN1-1   Q86VN1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPS36: NX_Q86VN1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86VN1

    • VPS36 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057159.2  
    ENSEMBL proteins: 
     ENSP00000367299  
    Reactome Protein details: Q86VN1
    Human Recombinant Protein Products: 
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    Novus Biologicals VPS36 Protein
    Novus Biologicals VPS36 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VPS36

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005764lysosome IEA--
    GO:0005768endosome IDA--
    GO:0005770late endosome IEA--
    GO:0005829cytosol TAS--


    VPS36 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for VPS36

    Protein Domains /
    Families
    for VPS36 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VPS36 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR007286 EAP30
     IPR021648 VPS36_GLUE

    Graphical View of Domain Structure for InterPro Entry Q86VN1

    ProtoNet protein and cluster: Q86VN1

    UniProtKB/Swiss-Prot: VPS36_HUMAN, Q86VN1
    Domain: The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates the binding to ubiquitin and phosphoinosides
    Similarity: Belongs to the VPS36 family
    Similarity: Contains 1 GLUE C-terminal domain
    Similarity: Contains 1 GLUE N-terminal domain


    Function
    for VPS36 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VPS36_HUMAN, Q86VN1
    Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required
    for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates
    delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably
    involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal
    sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription
    regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS36
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS36 (see all 33):
    hsa-miR-607 hsa-miR-29a hsa-miR-507 hsa-miR-570 hsa-miR-4325 hsa-miR-3690 hsa-miR-365 hsa-miR-320d
    SwitchGear 3'UTR luciferase reporter plasmid: VPS36 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032266phosphatidylinositol-3-phosphate binding IEA--
    GO:0043130ubiquitin binding IEA--


    VPS36 for ontologies           About GeneDecksing



    Pathways & Interactions
    for VPS36 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Membrane Trafficking
    		Membrane Trafficking1.00
    2Endocytosis
    		Endocytosis1.00
    3Signal Transduction
    		Endosomal Sorting Complex Required For Transport (ESCRT)0.14

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for VPS36
        Membrane Trafficking
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1         Kegg Pathway  (Kegg details for VPS36):
        Endocytosis


    VPS36 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/557 Interacting proteins for VPS36 (Q86VN12, 3 ENSP000003672994) via UniProtKB, MINT, STRING, and/or I2D (see all 557)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998162, 3, ENSP000002519684MINT-7947479 I2D: score=2 STRING: ENSP00000251968
    SNF8Q96H203, ENSP000002903304I2D: score=3 STRING: ENSP00000290330
    VPS25Q9BRG13, ENSP000002537944I2D: score=5 STRING: ENSP00000253794
    CHMP6Q96FZ73, ENSP000003174684I2D: score=2 STRING: ENSP00000317468
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0015031protein transport IEA--
    GO:0016044cellular membrane organization TAS--
    GO:0016197endosomal transport TAS--


    VPS36 for ontologies           About GeneDecksing



    Drugs & Compounds
    for VPS36 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS36
    Search CenterWatch for drugs/clinical trials and news about VPS36 

    Transcripts
    for VPS36 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VPS36 gene: 
    NM_016075.2  

    Unigene Cluster for VPS36:

    Vacuolar protein sorting 36 homolog (S. cerevisiae)
    Hs.109520  [show with all ESTs]
    Unigene Representative Sequence: AB208956
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378060(uc001vgq.3 uc001vgs.3) ENST00000497149 ENST00000462289
    ENST00000492650 ENST00000480923 ENST00000475375

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS36
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS36 (see all 33):
    hsa-miR-607 hsa-miR-29a hsa-miR-507 hsa-miR-570 hsa-miR-4325 hsa-miR-3690 hsa-miR-365 hsa-miR-320d
    SwitchGear 3'UTR luciferase reporter plasmid: VPS36 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: VPS36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS36
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS36

    Additional cDNA sequence: 

    AB208956.1 AF151903.1 AK022911.1 AK023182.1 AK094335.1 AK289740.1 BC037279.1 BC050439.1 
    BX647847.1 CR933653.1 

    14 DOTS entries:

    DT.100780812  DT.97787411  DT.448344  DT.304780  DT.95269296  DT.120790635  DT.100780810  DT.91708731 
    DT.95269294  DT.95365539  DT.86858579  DT.95269291  DT.95320447  DT.75172189 

    24/314 AceView cDNA sequences (see all 314):

    AK096289 BM711180 BM674913 CA944508 AA313982 CA446845 CK820208 AI565139 
    BQ023963 BM972213 BF671684 BG982544 BQ882779 CB069690 BM479747 AI554215 
    AI086307 AI269300 H58321 AI038557 BM126353 AI683536 BM713243 CA443877 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VPS36    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:              -     -                       -                                                                 -               
    SP2:                    -                       -                                                                 -               
    SP3:                    -                                                                                                         
    SP4:                                            -                                                                                 
    SP5:                                                                    -     -     -                 -                           


    ECgene alternative splicing isoforms for VPS36

    Expression
    for VPS36 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATGTATTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See VPS36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS36

    SOURCE GeneReport for Unigene cluster: Hs.109520
        SABiosciences Custom PCR Arrays for VPS36
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS36

    Orthologs
    for VPS36 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS36 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Vps361 , 5 vacuolar protein sorting 36 (yeast)1, 5 90.33(n)1
    95.85(a)1    		   8 (11.14 cM)5
    701601  NM_027338.11  NP_081614.11 
     221928095 
    chicken
    (Gallus gallus)    		 Aves VPS361 vacuolar protein sorting 36 homolog (S. cerevisiae) 80.57(n)
    89.64(a)    		   418883  XM_417077.3  XP_417077.1 
    lizard
    (Anolis carolinensis)    		 Reptilia VPS366
    		 --
    		 90(a)
    		 1 ↔ 1
    		 1(132683907-132711787)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.137682 Transcribed sequence with moderate similarity to protein more 78.34(n)    BX737003.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj33d072 wufj33d07 74.88(n)   335810  BC045509.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Vps361 Vacuolar protein sorting 36 54.3(n)
    47.37(a)    		   39523  NM_140403.1  NP_648660.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea vps-361 Protein VPS-36 51.32(n)
    43.39(a)    		   179520  NM_073397.4  NP_505798.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G049201 vacuolar protein sorting-associated protein 36 48.36(n)
    41.26(a)    		   830374  NM_120574.4  NP_196112.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g08135001 hypothetical protein 48.94(n)
    41.72(a)    		   4327592  NM_001051135.1  NP_001044600.1 


    ENSEMBL Gene Tree for VPS36 (if available)
    TreeFam Gene Tree for VPS36 (if available) 

    Paralogs
    for VPS36 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for VPS36 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/646 NCBI SNPs in VPS36 are shown (see all 646)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1159973551,2
    		F,--52986281(+) TGATGC/TAGGCA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1390397601,2
    		--52986325(+) GTGGGC/TGTGGG 1 -- int10--------
    rs1833977411,2
    		--52986627(+) GCTTAC/TATGTC 1 -- int10--------
    rs1876921021,2
    		--52986628(+) CTTACA/GTGTCT 1 -- int10--------
    rs1430497581,2
    		--52986643(+) CCCCAA/GCTAGG 1 -- int10--------
    rs1470332241,2
    		--52986652(+) GGTTTC/TCCTTT 1 -- int10--------
    rs1385776491,2
    		--52986671(+) ACACAC/GCTGTA 1 -- int10--------
    rs2022182301,2
    		--52986759(+) AAATG-/TTTTTT 1 -- ut310--------
    rs1925078411,2
    		--52986884(+) GCCCTA/GTTCTC 1 -- ut310--------
    rs1126971161,2
    		--52986899(+) CTTAGC/AATACA 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for VPS36 (52986737 - 53024763 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for VPS36
         1 Inversion: 37145

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    Disorders / Diseases
    for VPS36 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VPS36 for disorders           About GeneDecksing

    OMIM gene information: 610903    OMIM disorders: --

    1 disease for VPS36:    About MalaCards
    immunodeficiency


    Export disorders for VPS36 gene to outside databases

    Publications
    for VPS36 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS36 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with VPS36)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide- interacting GLUE domain. (PubMed id 15755741)1, 2, 3 Slagsvold T.... Stenmark H. (2005)
    2. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (2010)
    3. Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. (PubMed id 18539118)1, 2 Im Y.J. and Hurley J.H. (2008)
    4. Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. (PubMed id 17057716)1, 2 Alam S.L....Sundquist W.I. (2006)
    5. RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. (PubMed id 17010938)1, 2 Wang T. and Hong W. (2006)
    6. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. (PubMed id 16973552)1, 2 Langelier C.... Sundquist W.I. (2006)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)

    External Searches for VPS36 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing VPS36 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51028 HGNC: 20312 AceView: C13orf9andTHSD1 Ensembl:ENSG00000136100 euGenes: HUgn51028
    ECgene: VPS36 Kegg: 51028 H-InvDB: VPS36

    Other Databases showing VPS36 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VPS36 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS36 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VPS36 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VPS36 gene:
    Search GeneIP for patents involving VPS36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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