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Aliases for VPS36 Gene

Aliases for VPS36 Gene

  • Vacuolar Protein Sorting 36 Homolog (S. Cerevisiae) 2 3
  • EAP45 3 4 6
  • ELL-Associated Protein Of 45 KDa 3 4
  • ESCRT-II Complex Subunit VPS36 3 4
  • C13orf9 3 4
  • Vacuolar Protein-Sorting-Associated Protein 36 3
  • Vacuolar Protein Sorting 36 Homolog (Yeast) 2
  • Chromosome 13 Open Reading Frame 9 2
  • CGI-145 3

External Ids for VPS36 Gene

Previous Symbols for VPS36 Gene

  • C13orf9

Summaries for VPS36 Gene

Entrez Gene Summary for VPS36 Gene

  • This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

GeneCards Summary for VPS36 Gene

VPS36 (Vacuolar Protein Sorting 36 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Endocytosis and Clathrin derived vesicle budding. GO annotations related to this gene include ubiquitin binding and phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for VPS36 Gene

  • Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.

Gene Wiki entry for VPS36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS36 Gene

Genomics for VPS36 Gene

Genomic Location for VPS36 Gene

Start:
52,412,602 bp from pter
End:
52,450,678 bp from pter
Size:
38,077 bases
Orientation:
Minus strand

Genomic View for VPS36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS36 Gene

Regulatory Elements for VPS36 Gene

Proteins for VPS36 Gene

  • Protein details for VPS36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VN1-VPS36_HUMAN
    Recommended name:
    Vacuolar protein-sorting-associated protein 36
    Protein Accession:
    Q86VN1
    Secondary Accessions:
    • A8K125
    • Q3ZCV7
    • Q5H9S1
    • Q5VXB6
    • Q9H8Z5
    • Q9Y3E3

    Protein attributes for VPS36 Gene

    Size:
    386 amino acids
    Molecular mass:
    43817 Da
    Quaternary structure:
    • Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and two copies of VPS25. Interacts with VPS25, SNF8, TSG101 and VPS36. Interacts (via GLUE domain) with ubiquitin. Interacts with RILPL1 (via the C-terminal domain); which recruits ESCRT-II to the endosome membranes. Interacts with ECM29.
    SequenceCaution:
    • Sequence=BAB14451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VPS36 Gene

    Alternative splice isoforms for VPS36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS36 Gene

Proteomics data for VPS36 Gene at MOPED

Post-translational modifications for VPS36 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys102, Lys107, Lys218, and Lys298

Other Protein References for VPS36 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for VPS36 Gene

Domains for VPS36 Gene

Protein Domains for VPS36 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

VPS36_HUMAN
Domain:
  • The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates the binding to ubiquitin and phosphoinosides.:
    • Q86VN1
  • Contains 1 GLUE C-terminal domain.:
    • Q86VN1
  • Contains 1 GLUE N-terminal domain.:
    • Q86VN1
Family:
  • Belongs to the VPS36 family.:
    • Q86VN1
genes like me logo Genes that share domains with VPS36: view

No data available for Gene Families for VPS36 Gene

Function for VPS36 Gene

Molecular function for VPS36 Gene

UniProtKB/Swiss-Prot Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.

Gene Ontology (GO) - Molecular Function for VPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14505570
GO:0008022 protein C-terminus binding IPI 16973552
GO:0032266 phosphatidylinositol-3-phosphate binding IEA --
GO:0043130 ubiquitin binding IMP 16973552
genes like me logo Genes that share ontologies with VPS36: view

miRNA for VPS36 Gene

miRTarBase miRNAs that target VPS36

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS36 Gene

Localization for VPS36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS36 Gene

Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS36 Gene COMPARTMENTS Subcellular localization image for VPS36 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 4
lysosome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for VPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005764 lysosome IEA --
GO:0005768 endosome IDA 20682791
GO:0005770 late endosome --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with VPS36: view

Pathways for VPS36 Gene

genes like me logo Genes that share pathways with VPS36: view

Pathways by source for VPS36 Gene

1 KEGG pathway for VPS36 Gene

Gene Ontology (GO) - Biological Process for VPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with VPS36: view

Transcripts for VPS36 Gene

Unigene Clusters for VPS36 Gene

Vacuolar protein sorting 36 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS36 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: - - - -

Relevant External Links for VPS36 Gene

GeneLoc Exon Structure for
VPS36
ECgene alternative splicing isoforms for
VPS36

Expression for VPS36 Gene

mRNA expression in normal human tissues for VPS36 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS36 Gene

SOURCE GeneReport for Unigene cluster for VPS36 Gene Hs.109520

genes like me logo Genes that share expressions with VPS36: view

Orthologs for VPS36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VPS36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS36 36
  • 99.91 (n)
  • 100 (a)
VPS36 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS36 36
  • 92.4 (n)
  • 97.93 (a)
VPS36 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS36 36
  • 93.87 (n)
  • 98.96 (a)
VPS36 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps36 36
  • 90.33 (n)
  • 95.85 (a)
Vps36 16
Vps36 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS36 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vps36 36
  • 90.24 (n)
  • 96.11 (a)
chicken
(Gallus gallus)
Aves VPS36 36
  • 80.57 (n)
  • 89.64 (a)
VPS36 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS36 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13768 36
vps36 36
  • 76.68 (n)
  • 85.49 (a)
zebrafish
(Danio rerio)
Actinopterygii vps36 36
  • 73.91 (n)
  • 85.08 (a)
vps36 37
  • 85 (a)
OneToOne
wufj33d07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004755 36
  • 51.68 (n)
  • 45.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vps36 36
  • 54.3 (n)
  • 47.37 (a)
Vps36 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vps-36 36
  • 51.32 (n)
  • 43.12 (a)
vps-36 37
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER092W 36
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS36 36
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02541g 36
  • 40.73 (n)
  • 28.02 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06595 36
  • 46.41 (n)
  • 36.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vps36 36
  • 40.43 (n)
  • 24.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4113 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToOne
Species with no ortholog for VPS36:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS36 Gene

ENSEMBL:
Gene Tree for VPS36 (if available)
TreeFam:
Gene Tree for VPS36 (if available)

Paralogs for VPS36 Gene

No data available for Paralogs for VPS36 Gene

Variants for VPS36 Gene

Sequence variations from dbSNP and Humsavar for VPS36 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs13431 -- 52,413,342(+) CCATT(C/G)TTTTA utr-variant-3-prime
rs1056335 -- 52,415,728(-) TTATT(A/G)GAACT utr-variant-3-prime
rs1891009 -- 52,428,237(+) CAAGT(G/T)ACTGA intron-variant
rs2185546 -- 52,438,913(+) GACAA(A/T)GATAA intron-variant
rs3196949 -- 52,415,554(-) AACTT(C/G)ATCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VPS36 Gene

Variant ID Type Subtype PubMed ID
nsv428288 CNV Loss 18775914
nsv900084 CNV Gain 21882294
nsv7242 OTHER Inversion 18451855
dgv1588n71 CNV Loss 21882294

Relevant External Links for VPS36 Gene

HapMap Linkage Disequilibrium report
VPS36

Disorders for VPS36 Gene

No disorders were found for VPS36 Gene.

No data available for UniProtKB/Swiss-Prot for VPS36 Gene

Publications for VPS36 Gene

  1. Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide- interacting GLUE domain. (PMID: 15755741) Slagsvold T. … Stenmark H. (J. Biol. Chem. 2005) 2 3 4
  2. Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose. (PMID: 11278625) Kamura T. … Shilatifard A. (J. Biol. Chem. 2001) 2 3
  3. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. (PMID: 16973552) Langelier C. … Sundquist W.I. (J. Virol. 2006) 3 4
  4. RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. (PMID: 17010938) Wang T. … Hong W. (Biochem. Biophys. Res. Commun. 2006) 3 4
  5. Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. (PMID: 17057716) Alam S.L. … Sundquist W.I. (Nat. Struct. Mol. Biol. 2006) 3 4

Products for VPS36 Gene

  • antibodies-online proteins for VPS36
  • antibodies-online antibodies for VPS36
  • antibodies-online kits for VPS36

Sources for VPS36 Gene

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