Aliases for VPS36 Gene
External Ids for VPS36 Gene
Previous HGNC Symbols for VPS36 Gene
Previous GeneCards Identifiers for VPS36 Gene
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
GeneCards Summary for VPS36 Gene
VPS36 (Vacuolar Protein Sorting 36 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Endocytosis and Clathrin derived vesicle budding. GO annotations related to this gene include ubiquitin binding and phosphatidylinositol-3-phosphate binding.
UniProtKB/Swiss-Prot for VPS36 Gene
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.