Aliases for VPS35 Gene
Aliases for VPS35 Gene
External Ids for VPS35 Gene
- HGNC: 13487
- Entrez Gene: 55737
- Ensembl: ENSG00000069329
- OMIM: 601501
- UniProtKB: Q96QK1
Previous GeneCards Identifiers for VPS35 Gene
- GC16M037104
- GC16M046634
- GC16M046433
- GC16M046475
- GC16M046474
- GC16M045251
- GC16M046691
- GC16M032582
Summaries for VPS35 Gene
-
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for VPS35 Gene
VPS35 (VPS35, Retromer Complex Component) is a Protein Coding gene. Diseases associated with VPS35 include Parkinson Disease 17 and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Signaling by GPCR and Signaling by Wnt. GO annotations related to this gene include binding and protein transporter activity.
UniProtKB/Swiss-Prot for VPS35 Gene
-
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5 (PubMed:20923837).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS35 Gene
Genomics for VPS35 Gene
Regulatory Elements for VPS35 Gene
Enhancers for VPS35 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH16G046746 | 1.4 | FANTOM5 ENCODE dbSUPER | 11.2 | -58.8 | -58835 | 3.7 | PKNOX1 ATF1 NFIB ARID4B THRB ZNF48 RARA EGR1 FOS RELB | MYLK3 SHCBP1 VPS35 ORC6 GPT2 GC16M046768 GC16P046705 |
| GH16G046711 | 1.1 | Ensembl ENCODE dbSUPER | 11.5 | -22.0 | -21983 | 0.6 | RFX1 SAP130 NRF1 HLF CEBPB CEBPG CEBPA ZBTB33 | MYLK3 VPS35 ORC6 GC16P046705 GC16M046768 |
| GH16G046658 | 1 | Ensembl ENCODE | 11.9 | +30.3 | 30255 | 1.5 | CTCF TBL1XR1 MAX ZNF384 RELA POLR2A EED ZNF143 ETV6 RELB | VPS35 ORC6 ENSG00000261131 PIR53331 |
| GH16G046832 | 0.8 | ENCODE | 11.1 | -143.4 | -143426 | 0.2 | SOX13 SAP130 ARID4B CEBPG ZNF384 ZNF644 RARA YY1 ZNF664 NR2F6 | ORC6 VPS35 GPT2 C16orf87 CKBP1 |
| GH16G046735 | 0.7 | dbSUPER | 11.5 | -47.6 | -47632 | 3.6 | SOX13 FOXA2 PKNOX1 CEBPG THRB ZNF644 ZNF121 SOX5 HLF FOXA3 | MYLK3 VPS35 ORC6 SHCBP1 GPT2 GC16P046705 GC16M046768 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around VPS35 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the VPS35 gene promoter:
Regulatory Element Products
Genomic Location for VPS35 Gene
- Chromosome:
- 16
- Start:
- 46,656,132 bp from pter
- End:
- 46,689,518 bp from pter
- Size:
- 33,387 bases
- Orientation:
- Minus strand
Genomic View for VPS35 Gene
Genes around VPS35 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q11.2 by Ensembl
- 16q11.2 by Entrez Gene
- 16q11.2 by HGNC
VPS35 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VPS35 Gene
Proteins for VPS35 Gene
-
Protein details for VPS35 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96QK1-VPS35_HUMAN
- Recommended name:
- Vacuolar protein sorting-associated protein 35
- Protein Accession:
- Q96QK1
- Q561W2
- Q9H016
- Q9H096
- Q9H4P3
- Q9H8J0
- Q9NRS7
- Q9NVG2
- Q9NX80
- Q9NZK2
Protein attributes for VPS35 Gene
- Size:
- 796 amino acids
- Molecular mass:
- 91707 Da
- Quaternary structure:
-
- Component of the heterotrimeric retromer cargo-selective complex (CSC), also decribed as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:11102511). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (Probable). Interacts with VPS26A, VPS26B, VPS29, SNX1, SNX2, IGF2R, SNX3, GOLPH3, LRRK2, SLC11A2, WASHC2A, WASHC2C, FKBP15, WASHC1, RAB7A, SNX27, WASHC5, EHD1 (PubMed:11102511, PubMed:15078903, PubMed:17868075PubMed:22070227, PubMed:19553991, PubMed:21725319, PubMed:22070227, PubMed:22513087, PubMed:23331060, PubMed:23563491, PubMed:23395371, PubMed:24344282, PubMed:24980502, PubMed:17891154, PubMed:19531583). Interacts with MAGEL2; leading to recruitment of the TRIM27:MAGEL2 E3 ubiquitin ligase complex retromer-containing endosomes (PubMed:23452853).
- SequenceCaution:
-
- Sequence=AAG01989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91137.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14626.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for VPS35 Gene
Post-translational modifications for VPS35 Gene
Other Protein References for VPS35 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for VPS35
- Novus Biologicals Antibodies for VPS35
- Invitrogen Antibodies for VPS35
- antibodies-online Antibodies for VPS35: See all 34
- GeneTex VPS35 antibody for VPS35
-
Santa Cruz Biotechnology (SCBT) Antibodies for VPS35
Protein Products
-
OriGene Purified Proteins for VPS35
- Search Origene for MassSpec and Protein Over-expression Lysates for VPS35
- Origene Custom Protein Services for VPS35
- antibodies-online Proteins for VPS35: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for VPS35
No data available for DME Specific Peptides for VPS35 Gene
Domains & Families for VPS35 Gene
Gene Families for VPS35 Gene
Protein Domains for VPS35 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VPS35 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96QK1- Family:
-
- Belongs to the VPS35 family.
Function for VPS35 Gene
Molecular function for VPS35 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5 (PubMed:20923837).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11102511 |
| GO:0008565 | protein transporter activity | IEA | -- |
| GO:0031748 | D1 dopamine receptor binding | IPI | 27460146 |
Phenotypes for VPS35 Gene
- MGI mutant phenotypes for VPS35:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for VPS35:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VPS35
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VPS35 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VPS35 gene
- Search ViGene Biosciences for VPS35
CRISPR Products
-
OriGene CRISPR knockouts for VPS35
-
Santa Cruz Biotechnology (SCBT) CRISPR for VPS35
- GenScript: Design CRISPR guide RNA sequences for VPS35
miRNA for VPS35 Gene
- miRTarBase miRNAs that target VPS35
-
- hsa-mir-590-3p (MIRT016199)
- hsa-mir-27a-3p (MIRT028711)
- hsa-mir-24-3p (MIRT030421)
- hsa-mir-342-3p (MIRT043692)
- hsa-mir-15b-5p (MIRT046485)
- hsa-mir-4459 (MIRT464103)
- hsa-mir-6763-5p (MIRT464104)
- hsa-mir-3150a-3p (MIRT464105)
- hsa-mir-1273e (MIRT464106)
- hsa-mir-203b-3p (MIRT464107)
- hsa-mir-7158-3p (MIRT464108)
- hsa-mir-6825-5p (MIRT464109)
- hsa-mir-939-5p (MIRT464110)
- hsa-mir-1343-5p (MIRT464111)
- hsa-mir-3175 (MIRT464112)
- hsa-mir-25-5p (MIRT464113)
- hsa-mir-658 (MIRT464114)
- hsa-mir-4722-5p (MIRT464115)
- hsa-mir-6087 (MIRT464116)
- hsa-mir-1827 (MIRT464117)
- hsa-mir-219b-3p (MIRT464118)
- hsa-mir-8089 (MIRT464119)
- hsa-mir-4700-5p (MIRT464120)
- hsa-mir-4667-5p (MIRT464121)
- hsa-mir-4649-3p (MIRT464122)
- hsa-mir-4768-3p (MIRT464123)
- hsa-mir-940 (MIRT464124)
- hsa-mir-6893-5p (MIRT464125)
- hsa-mir-6808-5p (MIRT464126)
- hsa-mir-302f (MIRT464127)
- hsa-mir-6739-5p (MIRT464128)
- hsa-mir-6733-5p (MIRT464129)
- hsa-mir-4668-5p (MIRT464130)
- hsa-mir-3153 (MIRT464131)
- hsa-mir-5680 (MIRT464132)
- hsa-mir-499b-3p (MIRT464133)
- hsa-mir-499a-3p (MIRT464134)
miRNA Products
- Search ViGene Biosciences for VPS35
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for VPS35
- Browse OriGene Inhibitory RNA Products For VPS35
-
ViGene Biosciences ready-to-package AAV shRNAs for VPS35 gene
Clone Products
-
OriGene ORF clones in human for VPS35
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for VPS35
- VectorBuilder custom plasmid, inducible vectors for VPS35
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VPS35
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for VPS35
-
ViGene Biosciences adenoviral particle packaged cDNA for VPS35 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VPS35 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VPS35 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS35 Gene
Localization for VPS35 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VPS35 Gene
- Cytoplasm. Membrane; Peripheral membrane protein. Endosome. Early endosome. Late endosome. Note=Localizes to tubular profiles adjacent to endosomes. {ECO:0000269 PubMed:15078903}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| lysosome | 5 |
| endosome | 5 |
| plasma membrane | 3 |
| nucleus | 2 |
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | colocalizes_with mitochondrion | IDA | 26618722 |
| GO:0005764 | lysosome | IDA | -- |
| GO:0005765 | lysosomal membrane | IDA | 17897319 |
| GO:0005768 | endosome | IDA,IEA | 15078903 |
Pathways & Interactions for VPS35 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endocytosis | ||
| 2 | Signaling by GPCR | ||
| 3 | Signaling by Wnt |
.71
|
|
| 4 | WNT ligand biogenesis and trafficking | ||
Pathways by source for VPS35 Gene
3 Reactome pathways for VPS35 Gene
1 KEGG pathway for VPS35 Gene
Interacting Proteins for VPS35 Gene
Selected Interacting proteins:
ENSP00000299138
Q96QK1-VPS35_HUMAN
for VPS35 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0007040 | lysosome organization | IEA | -- |
| GO:0010628 | positive regulation of gene expression | IDA | 26618722 |
| GO:0010629 | negative regulation of gene expression | IEA | -- |
| GO:0010821 | regulation of mitochondrion organization | IGI | 26618722 |
No data available for SIGNOR curated interactions for VPS35 Gene
Transcripts for VPS35 Gene
mRNA/cDNA for VPS35 Gene
- (3) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (621) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VPS35 Gene
CRISPR Products
-
OriGene CRISPR knockouts for VPS35
-
Santa Cruz Biotechnology (SCBT) CRISPR for VPS35
- GenScript: Design CRISPR guide RNA sequences for VPS35
miRNA Products
- Search ViGene Biosciences for VPS35
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for VPS35
- Browse OriGene Inhibitory RNA Products For VPS35
-
ViGene Biosciences ready-to-package AAV shRNAs for VPS35 gene
Clone Products
-
OriGene ORF clones in human for VPS35
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for VPS35
- VectorBuilder custom plasmid, inducible vectors for VPS35
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VPS35
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - |
| ExUns: | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | |||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: | |||||||||||||||||
| SP11: | - | ||||||||||||||||
| SP12: | |||||||||||||||||
| SP13: | |||||||||||||||||
| SP14: |
Expression for VPS35 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VPS35 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of VPS35 Gene:
VPS35SOURCE GeneReport for Unigene cluster for VPS35 Gene:
Hs.454528mRNA Expression by UniProt/SwissProt for VPS35 Gene:
Q96QK1-VPS35_HUMAN
Tissue specificity:
Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.
Evidence on tissue expression from TISSUES for VPS35 Gene
- Nervous system(5)
- Lung(4.6)
- Intestine(4.5)
- Liver(4.4)
- Skin(2.9)
- Kidney(2.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for VPS35 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cerebellum
- ear
- head
- mouth
- olfactory bulb
- pharynx
Thorax:
- diaphragm
- esophagus
- heart
- lung
Abdomen:
- stomach
Pelvis:
- urethra
- urinary bladder
Limb:
- foot
- hand
- lower limb
- upper limb
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for VPS35
-
OriGene qPCR primer pairs and template standards for VPS35
No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for VPS35 Gene
Orthologs for VPS35 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | VPS35 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | VPS35 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | VPS35 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | VPS35 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Vps35 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Vps35 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | VPS35 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | VPS35 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.4247 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8144 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | vps35 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007683 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Vps35 34 35 |
|
||
| CG5625 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | vps-35 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS35 34 35 37 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B07535g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AEL107W 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | VPS35B 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0801600 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06284 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | vps35 34 |
|
- Species where no ortholog for VPS35 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for VPS35 Gene
(1) SIMAP similar genes for VPS35 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for VPS35 Gene
No data available for Paralogs for VPS35 Gene
Variants for VPS35 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs188286943 | Pathogenic, Parkinson disease 17 (PARK17) [MIM:614203] | 46,662,452(+) | GGAAT(C/T)GCTGA | reference, missense | |
| rs146795505 | Pathogenic | 46,689,707(+) | CGCCA(C/T)GGGGT | nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| rs797044948 | Pathogenic | 46,671,766(-) | TGAGC(A/G)GAGCC | reference, missense | |
| rs116254156 | Likely benign | 46,674,329(+) | TGAGC(C/T)TATTG | reference, missense | |
| rs140543776 | Likely benign | 46,660,622(+) | TTTTG(A/G)ATAAG | reference, synonymous-codon |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2975n100 | CNV | gain | 25217958 |
| esv3571142 | CNV | gain | 25503493 |
| esv3638534 | CNV | gain | 21293372 |
| esv3638538 | CNV | gain | 21293372 |
| esv3638540 | CNV | gain | 21293372 |
| esv3892855 | CNV | loss | 25118596 |
| nsv1066115 | CNV | gain | 25217958 |
| nsv428327 | CNV | gain | 18775914 |
| nsv526656 | CNV | gain | 19592680 |
| nsv572536 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
7.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.42;
27.89% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for VPS35 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS35 Gene
Disorders for VPS35 Gene
(4) MalaCards diseases for VPS35 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| parkinson disease 17 |
|
|
| hereditary late-onset parkinson disease |
|
|
| vps35-related parkinson disease |
|
|
| parkinson disease, late-onset |
|
|
Search VPS35 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
VPS35_HUMAN- Parkinson disease 17 (PARK17) [MIM:614203]: An autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269 PubMed:21763482, ECO:0000269 PubMed:21763483, ECO:0000269 PubMed:22517097, ECO:0000269 PubMed:23395371, ECO:0000269 PubMed:24819384, ECO:0000269 PubMed:24980502}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for VPS35
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- VPS35
No data available for Genatlas for VPS35 Gene
Publications for VPS35 Gene
- VPS35 mutations in Parkinson disease. (PMID: 21763482) Vilarino-Guell C. … Farrer M.J. (Am. J. Hum. Genet. 2011) 2 3 4 64
- Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. (PMID: 19531583) Seaman M.N. … Bright N. (J. Cell. Sci. 2009) 3 4 22 64
- Human homologues of yeast vacuolar protein sorting 29 and 35. (PMID: 11062004) Edgar A.J. … Polak J.M. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
- Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21. (PMID: 11112353) Zhang P. … Zhao S. (Genomics 2000) 2 3 4 64
- A mechanism for retromer endosomal coat complex assembly with cargo. (PMID: 24344282) Harrison M.S. … Burd C.G. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4 64
Products for VPS35 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for VPS35
- Browse OriGene ELISA Kits
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- OriGene Purified Proteins for VPS35
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- OriGene qPCR primer pairs and template standards for VPS35
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- GenScript: Next-day shipping cDNA ORF clone for VPS35 in any vector
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for VPS35
- Novus Biologicals proteins and lysates for VPS35
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for VPS35
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for VPS35
- antibodies-online Antibodies for VPS35: See all 34
- Search antibodies-online for kits
- antibodies-online Proteins for VPS35: See all 6
- Search antibodies-online for peptides
- GeneTex VPS35 antibody for VPS35
- Search GeneTex for Proteins for VPS35
- ViGene Biosciences adenoviral particle packaged cDNA for VPS35 gene
- ViGene Biosciences lentiviral particle packaged cDNA for VPS35 gene
- ViGene Biosciences ready-to-package AAV shRNAs for VPS35 gene
- Search ViGene Biosciences for VPS35
- Santa Cruz Biotechnology (SCBT) Antibodies for VPS35
- Search Santa Cruz Biotechnology (SCBT) for VPS35 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for VPS35
- Horizon Cell Lines for VPS35
- Cyagen custom Knockout/knockin (KOKI) mouse models for VPS35
- VectorBuilder custom plasmid, inducible vectors for VPS35
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VPS35
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for VPS35 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (133) NCBI Bookshelf
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- (141) ENCODE
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- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer