VPS35 Gene

Aliases
for VPS35 gene

Previous GC identifers: GC16M037104 GC16M046634 GC16M046433 GC16M046475 GC16M046474 GC16M045251 GC16M032582

Summaries
for VPS35 gene

Genomic Views
for VPS35 gene

RefSeq DNA sequence:

NC_000016.9  NC_018927.1  NT_010498.15  

SwitchGear Promoter luciferase reporter plasmid: VPS35 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS35

VPS35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M046691:  view genomic region     (about GC identifiers)

Proteins
for VPS35 gene

1 PDB 3D structure from and Proteopedia for VPS35:

2R17 (3D)    

Explore the universe of human proteins at neXtProt for VPS35: NX_Q96QK1

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: VPS35 OriGene Custom Protein Services for VPS35
	GenScript Custom Purified and Recombinant Proteins Services for VPS35
	Novus Biologicals VPS35 Proteins Novus Biologicals VPS35 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VPS35

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of VPS35
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): VPS35 OriGene Custom Antibody Services for VPS35
	GenScript Custom Superior Antibodies Services for VPS35
	Novus Biologicals VPS35 Antibodies
	Abcam antibodies for VPS35
	Uscn Antibodies for VPS35
	ThermoFisher Antibody for VPS35

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VPS35
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VPS35

Protein Domains /
Families
for VPS35 gene

ProtoNet protein and cluster: Q96QK1

Function
for VPS35 gene

miRNA Products:		OriGene 3'-UTR Clone: VPS35 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS35
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS35 (see all 12):
		hsa-miR-569 hsa-miR-3688-3p hsa-miR-513a-3p hsa-miR-586 hsa-miR-488 hsa-miR-371-5p hsa-miR-3161 hsa-miR-633
		SwitchGear 3'UTR luciferase reporter plasmid: VPS35 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS35 (see all 6) OriGene siRNA: VPS35
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS35

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for VPS35

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS35 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS35 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: VPS35 (NM_018206)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VPS35
		Search LifeMap BioReagents cell lines for VPS35

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS35

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Vps35)

Pathways & Interactions
for VPS35 gene

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for VPS35 gene

Transcripts
for VPS35 gene

Expression
for VPS35 gene

VPS35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTCCTCTG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS35 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS35
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS35
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS35

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS35

Orthologs
for VPS35 gene

Paralogs
for VPS35 gene

Paralogs for VPS35 gene

1 SIMAP similar gene for VPS35 using alignment to 4 protein entries:     VPS35_HUMAN (see all proteins):

DKFZp686O2462

VPS35 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for VPS35
PGOHUM00000249099

Genomic Variants
for VPS35 gene

10/356 NCBI SNPs in VPS35 are shown (see all 356)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1882869431,2	C,F	pathogenic	34973276(+)	GGAATC/TGCTGA	2	N D	mis1		3		EU	5092
rs1842770921,2	C	unknown	34966712(+)	AATCCG/ACTGAT	2	/R /W	mis1		3		EU	5096
rs115504611,2	C	--	32582925(+)	GTGAAT/CAATTT	1	--	ut31		1		NA	2
rs1924190291,2	F	--	32583175(+)	CTCCAG/TTGTGT	2	M L	mis1		2		EU	3754
rs16459431,2	C,H	--	32583369(-)	TAACAG/AAAGCT	1	--	int1		7		MN NS EA NA	606
rs80457591,2	C,	--	32583966(+)	tcaagC/G/Tgattc	1	--	int1		0	--	--	--	--
rs1116818441,2	C,	--	32584022(+)	CCACGA/CCTAGC	1	--	int1		1		CSA	1
rs1114452651,2	C,	--	32584768(+)	TTGTTA/CATCAG	1	--	int1		0	--	--	--	--
rs774767331,2	C,F,	--	32585512(+)	ACACAT/CTCAGT	1	--	int1		1		EA	120
rs346871001,2	C,F	--	32585639(+)	ATGCGA/TCTGTC	2	D V	mis1		3		NA	72

HapMap Linkage Disequilibrium report for VPS35 (46690054 - 46723430 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for VPS35: --
Human Gene Mutation Database (HGMD): VPS35

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS35

DNA2.0 Custom Variant and Variant Library Synthesis for VPS35

Disorders / Diseases
for VPS35 gene

Publications
for VPS35 gene

PubMed articles for VPS35 gene, integrated from 9 sources (see all 75) (see top 10): (articles sorted by number of sources associating them with VPS35)

Utopia: connect your pdf to the dynamic world of online information

1. VPS35 mutations in Parkinson disease. (PubMed id 21763482)^{1, 2, 3} Vilarino-Guell C.... Farrer M.J. (2011)
2. Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21. (PubMed id 11112353)^{1, 2, 3} Zhang P.... Zhao S. (2000)
3. Human homologues of yeast vacuolar protein sorting 29 and 35. (PubMed id 11062004)^{1, 2, 9} Edgar A.J. and Polak J.M. (2000)
4. Identification of VPS35 mutations replicated in French families with Parkinson disease. (PubMed id 22517097)^{1, 2} Lesage S.... Brice A. (2012)
5. A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. (PubMed id 21763483)^{1, 2} Zimprich A.... Strom T.M. (2011)
6. GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. (PubMed id 19553991)^{1, 2} Scott K.L.... Chin L. (2009)
7. Functional architecture of the retromer cargo-recognition complex. (PubMed id 17891154)^{1, 2} Hierro A.... Hurley J.H. (2007)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
9. Exportin 7 defines a novel general nuclear export pathway. (PubMed id 15282546)^{1, 2} Mingot J.-M.... Goerlich D. (2004)
10. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. (PubMed id 15247922)^{1, 2} Verges M.... Mostov K.E. (2004)
11. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
12. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
13. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. (PubMed id 11102511)^{1, 2} Renfrew Haft C.... Taylor S.I. (2000)
14. Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP T BC1D5. (PubMed id 19531583)^{1, 9} Seaman M.N....Bright N. (2009)
15. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
16. Rab GTPase-activating proteins in autophagy: regulatio n of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)¹ Popovic D....Dikic I. (2012)
17. Contribution of VPS35 genetic variability to LBD in th e Flanders-Belgian population. (PubMed id 22336192)¹ Verstraeten A....Theuns J. (2012)
18. Frameshift mutations of vacuolar protein sorting gene s in gastric and colorectal cancers with microsatellite instability. (PubMed id 21733561)¹ An C.H....Lee S.H. (2012)
19. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
20. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
21. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
22. Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. (PubMed id 22284051)¹ Zhang J....Caplan S. (2012)
23. The Asp620asn mutation in VPS35 is not a common cause of familial Parkinson's disease. (PubMed id 22278960)¹ Guella I....Goldwurm S. (2012)
24. Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease. (PubMed id 22410496)¹ Zhang Y....Chen S.D. (2012)
25. Identification of Alzheimer disease-associated variant s in genes that regulate retromer function. (PubMed id 22673115)¹ Vardarajan B.N....Farrer L.A. (2012)
26. Multiple repeat elements within the FAM21 tail link th e WASH actin regulatory complex to the retromer. (PubMed id 22513087)¹ Jia D....Rosen M.K. (2012)
27. Screening for VPS35 mutations in Parkinson's disease. (PubMed id 22154191)¹ Sheerin U.M....Wood N. (2012)
28. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
29. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
30. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
31. Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)¹ Berndt J.D....Moon R.T. (2011)
32. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S....Dorf M.E. (2011)
33. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)¹ Neganova I....Lako M. (2011)
34. Inhibition of retromer activity by herpesvirus saimir i tip leads to CD4 downregulation and efficient T cell transformation. (PubMed id 21849449)¹ Kingston D....Cho N.H. (2011)
35. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
36. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
37. Retromer disruption promotes amyloidogenic APP process ing. (PubMed id 21515373)¹ Sullivan C.P....Morin P.J. (2011)
38. Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)¹ Xu B....Karayiorgou M. (2011)
39. Retromer-mediated direct sorting is required for prop er endosomal recycling of the mammalian iron transporter DMT1. (PubMed id 20164305)¹ Tabuchi M....Kishi F. (2010)
40. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. (PubMed id 20923837)¹ Harbour M.E....Seaman M.N. (2010)
41. Vps35 mediates vesicle transport between the mitochon dria and peroxisomes. (PubMed id 20619655)¹ Braschi E....McBride H.M. (2010)
42. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
43. Proteomic dissection of cell type-specific H2AX-inter acting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)¹ Yang X....Chen X. (2010)
44. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
45. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
46. Analysis of articulation between clathrin and retrome r in retrograde sorting on early endosomes. (PubMed id 19874558)¹ Popoff V....Johannes L. (2009)
47. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)¹ Meierhofer D.... Kaiser P. (2008)
48. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
49. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. (PubMed id 17101778)¹ Rojas R....Bonifacino J.S. (2007)
50. Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. (PubMed id 17916227)¹ Zhao X....Arvan P. (2007)
51. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)
52. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)¹ Xiao K....Lefkowitz R.J. (2007)
53. Purification and identification of G protein-coupled receptor protein complexes under native conditions. (PubMed id 17215244)¹ Daulat A.M....Jockers R. (2007)
54. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
55. The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
56. Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)¹ Matsumoto M....Nakayama K.I. (2005)
57. A novel mammalian retromer component, Vps26B. (PubMed id 16190980)¹ Kerr M.C.... Teasdale R.D. (2005)
58. Proteomic analysis of ubiquitinated proteins from hum an MCF-7 breast cancer cells by immunoaffinity purification and mass spectromet ry. (PubMed id 16335966)¹ Vasilescu J....Figeys D. (2005)
59. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)

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