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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS33B Gene

protein-coding   GIFtS: 56
GCID: GC15M091541

Vacuolar Protein Sorting 33 Homolog B (Yeast)

(Previous name: vacuolar protein sorting 33B (yeast homolog))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vacuolar Protein Sorting 33 Homolog B (Yeast)1 2
hVPS33B2 3
Vacuolar Protein Sorting 33B (Yeast Homolog)1
Vacuolar Protein Sorting 33B2
Vacuolar Protein Sorting-Associated Protein 33B2

External Ids:    HGNC: 127121   Entrez Gene: 262762   Ensembl: ENSG000001840567   OMIM: 6085525   UniProtKB: Q9H2673   

Export aliases for VPS33B gene to outside databases

Previous GC identifers: GC15P087731 GC15M084982 GC15M089129 GC15M089271 GC15M089342 GC15M067652


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPS33B Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human
ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins
are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate
vesicle trafficking steps in the endosome/lysosome pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS33B Gene: 
VPS33B (vacuolar protein sorting 33 homolog B (yeast)) is a protein-coding gene. Diseases associated with VPS33B include arc syndrome, and vps33b-related arthrogryposis, renal dysfunction, and cholestasis syndrome. GO annotations related to this gene include protein binding. An important paralog of this gene is VPS33A.

UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages

Gene Wiki entry for VPS33B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS33B gene promoter:
         ER-alpha   HFH-3   AML1a   Olf-1   Lmo2   POU3F2 (N-Oct-5b)   Nkx2-5   c-Ets-1   E47   FOXI1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS33B promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS33B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS33B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

VPS33B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS33B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M091541:  view genomic region     (about GC identifiers)

Start:
91,541,646 bp from pter      End:
91,565,833 bp from pter
Size:
24,188 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 33B  
Size: 617 amino acids; 70585 Da
Subunit: Interacts with RAB11A and VIPAS39. Interacts with M.tuberculosis PtpA
Subcellular location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane;
Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late
endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and
associates with phagosomes. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles
Caution: According to PubMed:18474358, it is autophosphorylated. However, it is not related with protein kinases,
suggesting it is phosphorylated by another protein
Secondary accessions: Q96K14 Q9NRP6 Q9NSF3

Explore the universe of human proteins at neXtProt for VPS33B: NX_Q9H267

Explore proteomics data for VPS33B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues. Dephosphorylation by M.tuberculosis PtpA is necessary to induce the reduction
    of host phagolysosome fusion in M.tuberculosis-infected macrophages
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H267

  • VPS33B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VPS33B Protein Expression
    REFSEQ proteins: NP_061138.3  
    ENSEMBL proteins: 
     ENSP00000327650   ENSP00000460413   ENSP00000444053   ENSP00000446267  

    Human Recombinant Protein Products for VPS33B: 
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    Cloud-Clone Corp. Proteins for VPS33B 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15052268
    GO:0005764lysosome IDA15052268
    GO:0005765lysosomal membrane IEA--
    GO:0005770late endosome IDA15052268
    GO:0030897colocalizes with HOPS complex IDA19109425

    VPS33B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027121 VPS33
     IPR001619 Sec1-like
     IPR027482 Sec-1-like_dom2

    Graphical View of Domain Structure for InterPro Entry Q9H267

    ProtoNet protein and cluster: Q9H267

    1 Blocks protein domain: IPB001619 Sec1-like protein

    UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
    Similarity: Belongs to the STXBP/unc-18/SEC1 family


    VPS33B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VP33B_HUMAN, Q9H267
    Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
    docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    VPS33B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS33B:
     Small cells 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidVPS33B 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS33B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/785 Interacting proteins for VPS33B (Q9H2671, 2, 3 ENSP000003276504) via UniProtKB, MINT, STRING, and/or I2D (see all 785)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8IP2Q133872, 3MINT-8262673 I2D: score=2 
    VIPAS39Q9H9C11, 2, 3, ENSP000003391224EBI-749072,EBI-749080 MINT-8380411 MINT-8380389 MINT-67422 MINT-8380455 I2D: score=5 STRING: ENSP00000339122
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    ZAKQ9NYL22, 3, ENSP000003643614MINT-8277389 I2D: score=2 STRING: ENSP00000364361
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006904vesicle docking involved in exocytosis IEA--
    GO:0015031protein transport IMP15052268
    GO:0016192vesicle-mediated transport IDA15790593
    GO:0032400melanosome localization IDA15790593
    GO:0032418lysosome localization IDA15790593

    VPS33B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS33B (VP33B)

    Search CenterWatch for drugs/clinical trials and news about VPS33B / VP33B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPS33B gene: 
    NM_018668.3  

    Unigene Cluster for VPS33B:

    Vacuolar protein sorting 33 homolog B (yeast)
    Hs.745007  [show with all ESTs]
    Unigene Representative Sequence: NM_018668
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333371(uc002bqp.1 uc002bqq.1 uc010uqu.1) ENST00000557470
    ENST00000574755 ENST00000535906 ENST00000554660 ENST00000556096 ENST00000554264
    ENST00000557358 ENST00000535843
    miRNA
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    hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-16 hsa-miR-195 hsa-miR-15b hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidVPS33B 3' UTR sequence
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    Additional mRNA sequence: 

    AF201694.1 AF308803.1 AK027754.1 AK074863.1 AK293688.1 AK300608.1 AK308480.1 AK315721.1 
    AL357472.1 BC016445.1 

    16 DOTS entries:

    DT.441610  DT.100694312  DT.100776662  DT.121031376  DT.101967521  DT.75103845  DT.121031325  DT.97842704 
    DT.100776664  DT.121031276  DT.121031348  DT.92433072  DT.100774402  DT.121031283  DT.91669040  DT.121031395 

    24/146 AceView cDNA sequences (see all 146):

    BM713195 AI631066 AA700425 BE223017 AA463624 BQ066026 BM014183 BX281265 
    BC016445 AW139485 AI271343 AK074863 AI589203 AA626231 NM_018668 CR604260 
    BM808670 AA482390 CA429118 BQ898937 AA452072 CF132227 BU741299 AI690749 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VPS33B    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                -                                                               
    SP2:                                                                                                
    SP3:                                -     -                                                         
    SP4:                                                                                                
    SP5:                          -     -     -                                                         


    ECgene alternative splicing isoforms for VPS33B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS33B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTAAGAT
    VPS33B Expression
    About this image


    See VPS33B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS33B

    SOURCE GeneReport for Unigene cluster: Hs.745007

    UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
    Tissue specificity: Ubiquitous; highly expressed in testis and low expression in the lung

        SABiosciences Custom PCR Arrays for VPS33B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VPS33B gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps33b1 , 5 vacuolar protein sorting 33B (yeast)1, 5 91.25(n)1
    97.24(a)1
      7 (45.59 cM)5
    2334051  NM_178070.41  NP_835171.21 
     802696495 
    chicken
    (Gallus gallus)
    Aves VPS33B1 vacuolar protein sorting 33 homolog B (yeast) 77.16(n)
    81.66(a)
      425858  NM_001031348.1  NP_001026519.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS33B6
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL343759.1(725-13911)
    zebrafish
    (Danio rerio)
    Actinopterygii vps33b1 vacuolar protein sorting 33B 69.23(n)
    74.59(a)
      541534  NM_001014348.1  NP_001014370.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51273 vesicle-mediated transport 21(a)   96E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea C56C10.13
    vps-33.21
    Protein VPS-33.21 27(a)3
    43.76(n)1
    31.47(a)1
      II(6601271-6603325)3
    1740951  NM_062941.41  NP_495342.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS336
    ATP-binding protein that is a subunit of the HOPS ...
    18(a)
    1 → many
    XII(910235-912310)


    ENSEMBL Gene Tree for VPS33B (if available)
    TreeFam Gene Tree for VPS33B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPS33B gene
    VPS33A2  ENSG000002568612  
    1 SIMAP similar gene for VPS33B using alignment to 4 protein entries:     VP33B_HUMAN (see all proteins):
    VPS33A

    VPS33B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VPS33B
    PGOHUM00000260482


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/818 SNPs in VPS33B are shown (see all 818)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0189834
    Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1)4--see VAR_0189832 L P mis40--------
    VAR_0579014
    Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1)4--see VAR_0579012 S F mis40--------
    rs1214343841,2
    Cpathogenic171269644(-) ATCTGA/C/TGAAGA 2 R * stg11NA 4550
    rs571094731,2
    C--67658340(+) AAAAA-/A/A   
       AG
    /AG
    GAAGA
    2 -- int1 cds11NA 2
    rs1112740921,2
    C--67668554(+) GAGAGAA/-AGAAA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2014270221,2
    F--67668555(+) AGAGAA/GAGAAA 1 -- int11Minor allele frequency- G:0.01EU 1059
    rs80246021,2
    C--67671480(+) TTAAAA/TATATA 1 -- int10--------
    rs1895625811,2
    --67671503(+) ATATAA/TATATA 1 -- int10--------
    rs1827896591,2
    --67671505(+) ATATAA/TATATA 1 -- int10--------
    rs344074601,2
    C--67674635(+) AGACAT/-TTGTT 1 -- int12Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for VPS33B (91541646 - 91565833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VPS33B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672368CNV Deletion23128226
    nsv833091CNV Loss17160897
    nsv833090CNV Loss17160897


    Human Gene Mutation Database (HGMD): VPS33B
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608552   
    OMIM disorders: 208085  
    UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
  • Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1) [MIM:208085]: A multisystem
    disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal
    cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is
    common. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for VPS33B:    About MalaCards
    arc syndrome    vps33b-related arthrogryposis, renal dysfunction, and cholestasis syndrome    cholestasis    ichthyosis
    tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for VPS33B:
    ARC syndrome     Cholestasis

    VPS33B for disorders           About GeneDecksing

    Genetic Association Database (GAD): VPS33B
    Human Genome Epidemiology (HuGE) Navigator: VPS33B (2 documents)

    Export disorders for VPS33B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS33B gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with VPS33B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. (PubMed id 18474358)1, 2, 9 Bach H....Av-Gay Y. (2008)
    2. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)1, 4 Verma R....Levinson D.F. (2008)
    3. Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome. (PubMed id 15052268)1, 2 Gissen P.... Maher E.R. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PubMed id 11250079)1, 2 Huizing M.... Kraemer H. (2001)
    7. Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b. (PubMed id 10894945)1, 2 Carim-Todd L.... Escarceller M. (2000)
    8. Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. (PubMed id 8996080)1, 3 Pevsner J.... Scheller R.H. (1996)
    9. Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. (PubMed id 15790593)1, 9 Gissen P....Maher E.R. (2005)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26276 HGNC: 12712 AceView: VPS33B Ensembl:ENSG00000184056 euGenes: HUgn26276
    ECgene: VPS33B H-InvDB: VPS33B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS33B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPS33B gene:
    Search GeneIP for patents involving VPS33B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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