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Aliases & Descriptions for VPS33B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ14848 1, 2 | | hVPS33B 3 |
| | | Descriptions |
|---|
| vacuolar protein sorting 33 homolog B (yeast) 2 | | vacuolar protein sorting 33B 2 | | vacuolar protein sorting 33B (yeast homolog) 1 | | vacuolar protein sorting 33B (yeast homolog)) 2 |
|
| | Search outside databases for aliases for VPS33B genePrevious GC identifers: GC15P087731 GC15M084982 GC15M089129 GC15M089271 |
Summaries for VPS33B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VPS33B: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq] UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (By similarity)Gene Wiki entry for VPS33B |
Genomic Location for VPS33B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VPS33B gene 
Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26.1VPS33B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M089342:
(about GC identifiers)
Start:
|
89,342,778 bp from pter |
End:
|
89,366,837 bp from pter |
Size:
|
24,060 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000015.8 NT_010274.16
| Proteins for VPS33B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267 (See
protein sequence)Recommended Name: Vacuolar protein sorting-associated protein 33B Size: 617 amino acids; 70615 Da
Subcellular location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes
Secondary accessions: Q96K14 Q9NRP6 Q9NSF3REFSEQ proteins: NP_061138.3
ENSEMBL proteins: ENSP00000327650
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VPS33B: Assays for VPS33B: | Protein
Domains/ Families for VPS33B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H267
ProtoNet protein and cluster: Q9H267 1 Blocks protein family: IPB001619 Sec1-like protein
UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267Similarity: Belongs to the STXBP/unc-18/SEC1 family | Gene Function for VPS33B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018668
Applied Biosystems Silencer® siRNAs for VPS33B
Sigma-Aldrich siRNA for VPS33B  Sigma-Aldrich shRNA for VPS33B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018668                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018668                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018668 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018668
UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (By similarity) | Pathways & Interactions for VPS33B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for VPS33B (ENSP000003276503 Q9H2672) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for VPS33B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VPS33B
|
Transcripts for VPS33B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018668
Sigma-Aldrich siRNA for VPS33B  Sigma-Aldrich shRNA for VPS33B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018668 REFSEQ mRNAs for VPS33B gene: NM_018668.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018668               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018668                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018668                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018668  Additional cDNA sequence: AF201694.1 AF308803.1 AK027754.1 AK074863.1 AK293688.1 AK300608.1 AK308480.1 AK315721.1 AL357472.1 BC016445.1 CR604260.1 15 DOTS entries: DT.441610 DT.100694312 DT.100776662 DT.121031376 DT.101967521 DT.75103845 DT.121031325 DT.92433072 DT.97842704 DT.100776664 DT.121031276 DT.121031348 DT.100774402 DT.121031283 DT.121031395 24/146 AceView cDNA sequences (see all 146
):BM988158 BM828487 AW139485 BQ898937 AA463624 BQ066026 BE223017 AI589203 BM014183 CR604260 AL357472 BQ014188 AA452072 AA700425 CF132227 BP357794 AI271343 BC016445 CA429118 BQ642641 AA626231 BU741299 BM713195 BI554047
highest scoring ESTs for VPS33B:AA074575 AF201694 AF308803 AI672363 AK027754 AK074863 AL526736 AL530399 AL552186 AL556901 Unigene Cluster for VPS33B: Vacuolar protein sorting 33 homolog B (yeast) Hs.718508 [show with all ESTs]Unigene Representative Sequence: NM_018668
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for VPS33B
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VPS33B
1 Ensembl transcript including schematic representation: ENST00000333371
|
Expression for VPS33B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VPS33B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VPS33B
1 / 2 / 3 5 probe-sets matching VPS33B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGCTAAGAT
SOURCE GeneReport for Unigene cluster: Hs.718508 UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267Tissue specificity: Ubiquitous; highly expressed in testis and low expression in the lung |
Orthologs for VPS33B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VPS33B gene from 5/11 species (see all 11
)
About this table Species with no ortholog for VPS33B
ENSEMBL Gene Tree for VPS33B | Paralogs for VPS33B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VPS33B gene
- VPS33A2
|
SNPs/Variants for VPS33B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VPS33B (up to first 250kb)
|
Disorders & Mutations for VPS33B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608552 disorders: 208085 UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
Defects in VPS33B are the cause of arthrogryposis-renal dysfunction-cholestasis syndrome (ARC) [MIM:208085]. ARC is an autosomal recessive multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is commonHuman Gene Mutation Database: VPS33B Human Genome Epidemiology Navigator: VPS33B (1 document)
|
Medical News for VPS33B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VPS33B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for VPS33B gene (see all 15
):- Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome. (PubMed id 15052268)3, 4 Gissen P.... Maher E.R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PubMed id 11250079)3, 4 Huizing M.... Kraemer H. (2001)
- Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b. (PubMed id 10894945)3, 4 Carim-Todd L.... Escarceller M. (2000)
- Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. (PubMed id 8996080)2, 3 Pevsner J.... Scheller R.H. (1996)
- Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. (PubMed id 15790593)1, 3 Gissen P....Maher E.R. (2005)
- Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. (PubMed id 18474358)1, 3 Bach H....Av-Gay Y. (2008)
- Molecular investigations to improve diagnostic accuracy in patients with ARC syndrome. (PubMed id 18853461)4 Cullinane A.R.... Gissen P. (2009)
- Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)3 Verma R....Levinson D.F. (2008)
|
Search for VPS33B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VPS33B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VPS33B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VPS33B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VPS33B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VPS33B:

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