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VPS33B Gene

protein-coding   GIFtS: 53
GCID: GC15M091541

Vacuolar Protein Sorting 33 Homolog B (Yeast)

(Previous name: vacuolar protein sorting 33B (yeast homolog))
  See VPS33B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 33 Homolog B (Yeast)1 2
Vacuolar Protein Sorting 33B (Yeast Homolog)1
Vacuolar Protein Sorting-Associated Protein 33B2
hVPS33B3

External Ids:    HGNC: 127121   Entrez Gene: 262762   Ensembl: ENSG000001840567   OMIM: 6085525   UniProtKB: Q9H2673   

Export aliases for VPS33B gene to outside databases

Previous GC identifers: GC15P087731 GC15M084982 GC15M089129 GC15M089271 GC15M089342 GC15M067652


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS33B Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human
ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar
protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast
counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are
associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for VPS33B Gene:
VPS33B (vacuolar protein sorting 33 homolog B (yeast)) is a protein-coding gene. Diseases associated with VPS33B include vps33b-related arthrogryposis, renal dysfunction, and cholestasis syndrome, and arc syndrome. An important paralog of this gene is VPS33A.

UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages

Gene Wiki entry for VPS33B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the VPS33B gene promoter:
         ER-alpha   HFH-3   AML1a   Olf-1   Lmo2   POU3F2 (N-Oct-5b)   Nkx2-5   c-Ets-1   E47   FOXI1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS33B promoter sequence
   Search Chromatin IP Primers for VPS33B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS33B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

VPS33B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS33B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M091541:  view genomic region     (about GC identifiers)

Start:
91,541,646 bp from pter      End:
91,565,833 bp from pter
Size:
24,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 33B  
Size: 617 amino acids; 70585 Da
Subunit: Interacts with RAB11A and VIPAS39. Interacts with M.tuberculosis PtpA
Caution: According to PubMed:18474358, it is autophosphorylated. However, it is not related with protein kinases,
suggesting it is phosphorylated by another protein
Secondary accessions: Q96K14 Q9NRP6 Q9NSF3

Explore the universe of human proteins at neXtProt for VPS33B: NX_Q9H267

Explore proteomics data for VPS33B at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues. Dephosphorylation by M.tuberculosis PtpA is necessary to induce the reduction
    of host phagolysosome fusion in M.tuberculosis-infected macrophages1
  • Ubiquitination2 at Lys19, Lys304
  • Modification sites at PhosphoSitePlus

  • See VPS33B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276077.1  NP_001276078.1  NP_061138.3  

    ENSEMBL proteins: 
     ENSP00000327650   ENSP00000460413   ENSP00000444053   ENSP00000446267  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027121 VPS33
     IPR001619 Sec1-like
     IPR027482 Sec-1-like_dom2

    Graphical View of Domain Structure for InterPro Entry Q9H267

    ProtoNet protein and cluster: Q9H267

    1 Blocks protein domain: IPB001619 Sec1-like protein

    UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
    Similarity: Belongs to the STXBP/unc-18/SEC1 family


    Find genes that share domains with VPS33B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VP33B_HUMAN, Q9H267
    Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
    docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with VPS33B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS33B:
     Small cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Vps33b):
     mortality/aging 

    Find genes that share phenotypes with VPS33B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS33B
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    hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-16 hsa-miR-195 hsa-miR-15b hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidVPS33B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VP33B_HUMAN, Q9H267: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane;
    Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late
    endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and
    associates with phagosomes. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    cytosol3
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15052268
    GO:0005764lysosome IDA15052268
    GO:0005765lysosomal membrane IEA--
    GO:0005770late endosome IDA15052268
    GO:0030897colocalizes with HOPS complex IDA19109425

    Find genes that share ontologies with VPS33B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS33B
    Interactions:

        Search GeneGlobe Interaction Network for VPS33B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS33B (Q9H2671, 2, 3 ENSP000003276504) via UniProtKB, MINT, STRING, and/or I2D (see all 840)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8IP2Q133872, 3MINT-8262673 I2D: score=2 
    VIPAS39Q9H9C11, 2, 3, ENSP000003391224EBI-749072,EBI-749080 MINT-8380411 MINT-8380389 MINT-67422 MINT-8380455 I2D: score=5 STRING: ENSP00000339122
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    EXOC4Q96A652, ENSP000002538614MINT-7945693 MINT-7947479 STRING: ENSP00000253861
    EXOC7Q9UPT52, ENSP000003341004MINT-7945693 MINT-7947479 STRING: ENSP00000334100
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006904vesicle docking involved in exocytosis IEA--
    GO:0015031protein transport IMP15052268
    GO:0016192vesicle-mediated transport IDA15790593
    GO:0032400melanosome localization IDA15790593
    GO:0032418lysosome localization IDA15790593

    Find genes that share ontologies with VPS33B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS33B (VP33B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS33B gene (3 alternative transcripts): 
    NM_001289148.1  NM_001289149.1  NM_018668.4  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333371(uc002bqp.1 uc002bqq.1 uc010uqu.1) ENST00000557470
    ENST00000574755 ENST00000535906 ENST00000554660 ENST00000556096 ENST00000554264
    ENST00000557358 ENST00000535843
    miRNA
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    hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-16 hsa-miR-195 hsa-miR-15b hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidVPS33B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS33B
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      QuantiTect SYBR Green Assays in human, mouse, rat VPS33B
      QuantiFast Probe-based Assays in human, mouse, rat VPS33B

    Selected AceView cDNA sequences (see all 146):

    BC016445 BQ642641 AA626231 AK074863 BE223017 AA482390 AA700425 BQ898937 
    BM828487 BM808670 BM014183 AI127886 BI554047 BQ014188 BP357794 AI631066 
    BX281265 CR604260 BU741299 AI690749 AI589203 AL357472 CF132227 BQ066026 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VPS33B    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                -                                                               
    SP2:                                                                                                
    SP3:                                -     -                                                         
    SP4:                                                                                                
    SP5:                          -     -     -                                                         


    ECgene alternative splicing isoforms for VPS33B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS33B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTAAGAT
    VPS33B Expression
    About this image

    VPS33B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS33B Protein Expression

    UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
    Tissue specificity: Ubiquitous; highly expressed in testis and low expression in the lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VPS33B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps33b1 , 5 vacuolar protein sorting 33B (yeast)1, 5 91.25(n)1
    97.24(a)1
      7 (45.59 cM)5
    2334051  NM_178070.41  NP_835171.21 
     802696495 
    chicken
    (Gallus gallus)
    Aves VPS33B1 vacuolar protein sorting 33 homolog B (yeast) 77.16(n)
    81.66(a)
      425858  NM_001031348.1  NP_001026519.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS33B6
    vacuolar protein sorting 33 homolog B (yeast)
    79(a)
    1 ↔ 1
    GL343759.1(725-13911)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vps33b1 vacuolar protein sorting 33 homolog B 69.96(n)
    76.15(a)
      100125133  NM_001103034.1  NP_001096504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vps33b1 vacuolar protein sorting 33B 69.23(n)
    74.59(a)
      541534  NM_001014348.1  NP_001014370.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51273 vesicle-mediated transport 21(a)   96E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea C56C10.13
    vps-33.21
    vps-33.21 27(a)3
    43.82(n)1
    31.65(a)1
      II(6601271-6603325)3
    1740951  NM_062941.51  NP_495342.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS336
    ATP-binding protein that is a subunit of the HOPS ...
    19(a)
    1 → many
    XII(910235-912310) YLR396C


    ENSEMBL Gene Tree for VPS33B (if available)
    TreeFam Gene Tree for VPS33B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS33B gene
    VPS33A2  ENSG000002568612  
    1 SIMAP similar gene for VPS33B using alignment to 4 protein entries:     VP33B_HUMAN (see all proteins):
    VPS33A

    Find genes that share paralogs with VPS33B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for VPS33B
    PGOHUM00000260482


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS33B (see all 818)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0189834
    Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1)4--see VAR_0189832 L P mis40--------
    VAR_0579014
    Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1)4--see VAR_0579012 S F mis40--------
    rs1214343841,2
    Cpathogenic171269644(-) ATCTGA/C/TGAAGA 2 R * stg11NA 4550
    rs571094731,2
    C--67658340(+) AAAAA-/A/A   
       AG
    /AG
    GAAGA
    2 -- int1 cds11NA 2
    rs1112740921,2
    C--67668554(+) GAGAGAA/-AGAAA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2014270221,2
    F--67668555(+) AGAGAA/GAGAAA 1 -- int11Minor allele frequency- G:0.01EU 1059
    rs80246021,2
    C--67671480(+) TTAAAA/TATATA 1 -- int10--------
    rs1895625811,2
    --67671503(+) ATATAA/TATATA 1 -- int10--------
    rs1827896591,2
    --67671505(+) ATATAA/TATATA 1 -- int10--------
    rs344074601,2
    C--67674635(+) AGACAT/-TTGTT 1 -- int12Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for VPS33B (91541646 - 91565833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VPS33B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672368CNV Deletion23128226
    nsv833091CNV Loss17160897
    nsv833090CNV Loss17160897

    Human Gene Mutation Database (HGMD): VPS33B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS33B
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS33B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608552   
    OMIM disorders: 208085  
    UniProtKB/Swiss-Prot: VP33B_HUMAN, Q9H267
  • Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1) [MIM:208085]: A multisystem
    disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal
    cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is
    common. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for VPS33B:    
    About MalaCards
    vps33b-related arthrogryposis, renal dysfunction, and cholestasis syndrome    arc syndrome    arthrogryposis, renal dysfunction, and cholestasis 1    ivic syndrome
    cholestasis

    2 diseases from the University of Copenhagen DISEASES database for VPS33B:
    ARC syndrome     Cholestasis

    Find genes that share disorders with VPS33B           About GenesLikeMe

    Genetic Association Database (GAD): VPS33B
    Human Genome Epidemiology (HuGE) Navigator: VPS33B (2 documents)

    Export disorders for VPS33B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for VPS33B gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with VPS33B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. (PubMed id 18474358)1, 2, 9 Bach H.... Av-Gay Y. (Cell Host Microbe 2008)
    2. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. (PubMed id 18367154)1, 4 Verma R....Levinson D.F. (Biol. Psychiatry 2008)
    3. Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome. (PubMed id 15052268)1, 2 Gissen P.... Maher E.R. (Nat. Genet. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PubMed id 11250079)1, 2 Huizing M.... Kraemer H. (Gene 2001)
    7. Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b. (PubMed id 10894945)1, 2 Carim-Todd L.... Escarceller M. (Cytogenet. Cell Genet. 2000)
    8. Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. (PubMed id 8996080)1, 3 Pevsner J.... Scheller R.H. (Gene 1996)
    9. Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. (PubMed id 15790593)1, 9 Gissen P....Maher E.R. (Hum. Mol. Genet. 2005)
    10. Two novel VPS33B mutations in a patient with arthrogryposis, renal dysfunction and cholestasis syndrome in mainland China. (PubMed id 24415890)1 Li L.T....Wang J.S. (World J. Gastroenterol. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26276 HGNC: 12712 AceView: VPS33B Ensembl:ENSG00000184056 euGenes: HUgn26276
    ECgene: VPS33B H-InvDB: VPS33B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VPS33B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VPS33B gene:
    Search GeneIP for patents involving VPS33B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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