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VPS33A Gene

protein-coding   GIFtS: 55
GCID: GC12M122716

Vacuolar Protein Sorting 33 Homolog A (S. Cerevisiae)

(Previous name: vacuolar protein sorting 33A (yeast))
  See VPS33A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 33 Homolog A (S. Cerevisiae)1 2
hVPS33A2 3
Vacuolar Protein Sorting 33A (Yeast)1
Vacuolar Protein Sorting 33A2
Vacuolar Protein Sorting-Associated Protein 33A2

External Ids:    HGNC: 181791   Entrez Gene: 650822   Ensembl: ENSG000001397197   OMIM: 6100345   UniProtKB: Q96AX13   

Export aliases for VPS33A gene to outside databases

Previous GC identifers: GC12M121416 GC12P122609 GC12M122524 GC12M121153 GC12M121241 GC12M121282 GC12M119676


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS33A Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and it encodes a protein
similar to the yeast class C Vps33 protein. The mammalian class C VPS proteins are predominantly associated with
late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the
endosome/lysosome pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS33A Gene:
VPS33A (vacuolar protein sorting 33 homolog A (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS33A include arc syndrome. An important paralog of this gene is VPS33B.

UniProtKB/Swiss-Prot: VP33A_HUMAN, Q96AX1
Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
docking/fusion reactions of late endosomes/lysosomes (By similarity)

Gene Wiki entry for VPS33A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS33A gene promoter:
         AhR   USF1   Pbx1a   CUTL1   MIF-1   Tal-1beta   E47   USF-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS33A promoter sequence
   Search Chromatin IP Primers for VPS33A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS33A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

VPS33A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS33A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122716:  view genomic region     (about GC identifiers)

Start:
122,714,111 bp from pter      End:
122,751,068 bp from pter
Size:
36,958 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VP33A_HUMAN, Q96AX1 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 33A  
Size: 596 amino acids; 67611 Da
Subunit: Large heterooligomeric complex together with VPS11, VPS16 and VPS18. Interacts with STX7 (By similarity).
Interacts with VIPAS39
Sequence caution: Sequence=BAB15570.1; Type=Frameshift; Positions=140;
2 PDB 3D structures from and Proteopedia for VPS33A:
4BX8 (3D)        4BX9 (3D)    
Secondary accessions: Q547V4 Q9H5Q0

Explore the universe of human proteins at neXtProt for VPS33A: NX_Q96AX1

Explore proteomics data for VPS33A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77, Lys126, Lys316, Lys335
  • Modification sites at PhosphoSitePlus

  • See VPS33A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075067.2  
    ENSEMBL proteins: 
     ENSP00000267199   ENSP00000442392   ENSP00000439255   ENSP00000442951  

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    Cloud-Clone Corp. Proteins for VPS33A

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027121 VPS33
     IPR001619 Sec1-like
     IPR027482 Sec-1-like_dom2

    Graphical View of Domain Structure for InterPro Entry Q96AX1

    ProtoNet protein and cluster: Q96AX1

    1 Blocks protein domain: IPB001619 Sec1-like protein

    UniProtKB/Swiss-Prot: VP33A_HUMAN, Q96AX1
    Similarity: Belongs to the STXBP/unc-18/SEC1 family


    Find genes that share domains with VPS33A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VP33A_HUMAN, Q96AX1
    Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
    docking/fusion reactions of late endosomes/lysosomes (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19109425
         
    Find genes that share ontologies with VPS33A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS33A:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vps33a):
     hematopoietic system  homeostasis/metabolism  integument  pigmentation  renal/urinary system 
     vision/eye 

    Find genes that share phenotypes with VPS33A           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS33A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS33A

    miRNA
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    miRTarBase miRNAs that target VPS33A:
    hsa-mir-26b-5p (MIRT029192), hsa-mir-98-5p (MIRT027508)

    Block miRNA regulation of human, mouse, rat VPS33A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS33A (see all 9):
    hsa-miR-4311 hsa-miR-3653 hsa-miR-520a-5p hsa-miR-1205 hsa-miR-27b* hsa-miR-1184 hsa-miR-544 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidVPS33A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS33A

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    GenScript: all cDNA clones in your preferred vector: VPS33A (NM_022916)
    Sino Biological Human cDNA Clone for VPS33A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VP33A_HUMAN, Q96AX1: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
    Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Cytoplasmic, peripheral
    membrane protein associated with late endosomes/lysosomes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    cytosol2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005769early endosome IDA19109425
    GO:0005770late endosome IDA19109425
    GO:0030897colocalizes with HOPS complex IDA19109425
    GO:0031902late endosome membrane IEA--

    Find genes that share ontologies with VPS33A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS33A
    Interactions:

        Search GeneGlobe Interaction Network for VPS33A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS33A (Q96AX12, 3 ENSP000002671994) via UniProtKB, MINT, STRING, and/or I2D (see all 640)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681042, 3MINT-7947479 I2D: score=1 
    FEN1P397482, 3MINT-7947479 I2D: score=1 
    HSP90AA1P079002, 3MINT-7947479 I2D: score=1 
    HIP1RO751462, 3, ENSP000002530834MINT-7947479 I2D: score=1 STRING: ENSP00000253083
    VPS41P497543, ENSP000003094574I2D: score=5 STRING: ENSP00000309457
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006904vesicle docking involved in exocytosis IEA--
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport IDA15790593
    GO:0030220platelet formation ISS--
    GO:0032400melanosome localization IDA15790593

    Find genes that share ontologies with VPS33A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS33A (VP33A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS33A gene: 
    NM_022916.4  

    Unigene Cluster for VPS33A:

    Vacuolar protein sorting 33 homolog A (S. cerevisiae)
    Hs.592009  [show with all ESTs]
    Unigene Representative Sequence: NM_022916
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267199(uc001ucd.3) ENST00000543633 ENST00000541169 ENST00000536212
    ENST00000540669 ENST00000544349 ENST00000542790 ENST00000542310 ENST00000451053

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VPS33A (see all 9):
    hsa-miR-4311 hsa-miR-3653 hsa-miR-520a-5p hsa-miR-1205 hsa-miR-27b* hsa-miR-1184 hsa-miR-544 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidVPS33A 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS33A
      QuantiTect SYBR Green Assays in human, mouse, rat VPS33A
      QuantiFast Probe-based Assays in human, mouse, rat VPS33A

    Additional mRNA sequence: 

    AF439857.1 AK026048.1 AK026840.1 AK315545.1 BC016617.1 

    12 DOTS entries:

    DT.308181  DT.92430696  DT.40190593  DT.100749478  DT.213186  DT.91686113  DT.100728586  DT.92430706 
    DT.95267531  DT.95267532  DT.95267535  DT.95345135 

    Selected AceView cDNA sequences (see all 436):

    NM_138929 AA744760 CB158118 AI951316 BU678922 BM799174 AF298770 AA661646 
    BM766003 AI459087 AF262240 F05220 AA668767 BM793173 CR600692 BI334702 
    BE791785 AA325771 BX119840 BX095332 BF724951 BQ021141 AA961109 CR612340 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS33A (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
    SP1:              -     -                             -                       -     -     -                                                               
    SP2:                                                                          -     -     -                                                               
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:              -     -                                                                                                                                 


    ECgene alternative splicing isoforms for VPS33A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS33A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATACAGA
    VPS33A Expression
    About this image

    VPS33A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS33A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592009
        Custom PCR Arrays for VPS33A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS33A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS33A gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps33a1 , 5 vacuolar protein sorting 33A (yeast)1, 5 86.91(n)1
    97.82(a)1
      5 (63.03 cM)5
    775731  NM_029929.31  NP_084205.31 
     1235287645 
    chicken
    (Gallus gallus)
    Aves VPS33A1 vacuolar protein sorting 33 homolog A (S. cerevisiae) 78.79(n)
    91.75(a)
      416861  XM_415153.3  XP_415153.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    1 → many
    GL343423.1(35272-73204)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vps33a1 vacuolar protein sorting 33 homolog A 75.13(n)
    86.1(a)
      549689  NM_001016935.2  NP_001016935.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vps33a1 vacuolar protein sorting 33A 73.29(n)
    84.68(a)
      448942  NM_001099973.1  NP_001093443.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta car1 , 3 ommochrome biosynthesis SNARE binding3
    carnation1
    43(a)3
    49.43(n)1
    45.88(a)1
      1 18D13
    329471  NM_001272778.11  NP_001259707.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0303.93 SLP-1 25(a)   III(8772650-8774850)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS33(YLR396C)4 ATP-binding protein that is a subunit of the HOPS complex more   --   12(912310-910235) 851112  NP_013500.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATVPS331 ATVPS33 47.9(n)
    39.34(a)
      824651  NM_001161207.1  NP_001154679.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g02230001 Os04g0223000 49.03(n)
    40.25(a)
      4335201  NM_001058805.1  NP_001052270.1 


    ENSEMBL Gene Tree for VPS33A (if available)
    TreeFam Gene Tree for VPS33A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS33A gene
    VPS33B2  ENSG000002568612  
    Selected SIMAP similar genes for VPS33A using alignment to 5 protein entries:     VP33A_HUMAN (see all proteins) (see all similar genes):
    EIF3G    pp12301    ARL6IP5    TNNT1    C12orf76    LSM12
    ARIH1    PFKFB3    ADCK1    CALCOCO2    HBP1    NAE1
    RRM2B    SEPSECS    SMYD4    AAMDC    COQ5    EIF3K

    Find genes that share paralogs with VPS33A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS33A (see all 874)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734217191,2
    C,F--122715620(+) GTTGCC/TCCTGC 1 -- int12Minor allele frequency- T:0.07WA 120
    rs1863219411,2
    --122715634(+) CTGTGA/GGACCA 1 -- int10--------
    rs1153799501,2
    F--122715753(+) ATTACT/CTCAAA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1495779471,2
    --122715850(+) GCTGAA/TCACAT 1 -- int10--------
    rs1442879321,2
    --122715861(+) AGAGCA/GTAAAC 1 -- int10--------
    rs1487555711,2
    --122715929(+) GCAAAC/TTTGCC 1 -- int10--------
    rs1916032591,2
    --122715950(+) GTTGCA/GACAGT 1 -- int10--------
    rs20682231,2
    C,F,A,H--122716068(+) GATGCG/ACCTTG 1 -- int121Minor allele frequency- A:0.30NS EA NA WA 2528
    rs284397491,2
    C,F,H--122716189(+) AATGGA/GTTATC 1 -- ut3112Minor allele frequency- G:0.05NS NA WA 1588
    rs1395786461,2
    C--122716290(+) TGATT-/TTC   
       TTCTA
    TTCTT
    1 -- ut310--------

    HapMap Linkage Disequilibrium report for VPS33A (122714111 - 122751068 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VPS33A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS33A
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS33A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610034    OMIM disorders: --

    1 disease for VPS33A:    
    About MalaCards
    arc syndrome

    2 diseases from the University of Copenhagen DISEASES database for VPS33A:
    Hermansky-Pudlak syndrome     ARC syndrome

    Find genes that share disorders with VPS33A           About GenesLikeMe


    Export disorders for VPS33A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS33A gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with VPS33A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery. (PubMed id 19109425)1, 2 Zhu G.D.... L'hernault S.W. (Mol. Biol. Cell 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation. (PubMed id 12538872)1, 2 Suzuki T.... Spritz R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    5. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PubMed id 11250079)1, 3 Huizing M.... Kraemer H. (Gene 2001)
    6. Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. (PubMed id 15790593)1, 9 Gissen P....Maher E.R. (Hum. Mol. Genet. 2005)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65082 HGNC: 18179 AceView: DIABLOandVPS33A Ensembl:ENSG00000139719 euGenes: HUgn65082
    ECgene: VPS33A H-InvDB: VPS33A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS33A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS33A gene:
    Search GeneIP for patents involving VPS33A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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