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Aliases for VPS33A Gene

Aliases for VPS33A Gene

  • Vacuolar Protein Sorting 33 Homolog A (S. Cerevisiae) 2 3
  • HVPS33A 3 4
  • Vacuolar Protein Sorting-Associated Protein 33A 3
  • Vacuolar Protein Sorting 33A (Yeast) 2
  • Vacuolar Protein Sorting 33A 3

External Ids for VPS33A Gene

Previous GeneCards Identifiers for VPS33A Gene

  • GC12M121416
  • GC12P122609
  • GC12M122524
  • GC12M121153
  • GC12M121241
  • GC12M121282
  • GC12M122716
  • GC12M119676

Summaries for VPS33A Gene

Entrez Gene Summary for VPS33A Gene

  • Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and it encodes a protein similar to the yeast class C Vps33 protein. The mammalian class C VPS proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for VPS33A Gene

VPS33A (Vacuolar Protein Sorting 33 Homolog A (S. Cerevisiae)) is a Protein Coding gene. An important paralog of this gene is VPS33B.

UniProtKB/Swiss-Prot for VPS33A Gene

  • May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.

Gene Wiki entry for VPS33A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS33A Gene

Genomics for VPS33A Gene

Regulatory Elements for VPS33A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VPS33A Gene

Start:
122,229,564 bp from pter
End:
122,266,521 bp from pter
Size:
36,958 bases
Orientation:
Minus strand

Genomic View for VPS33A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS33A Gene

Proteins for VPS33A Gene

  • Protein details for VPS33A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AX1-VP33A_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 33A
    Protein Accession:
    Q96AX1
    Secondary Accessions:
    • Q547V4
    • Q9H5Q0

    Protein attributes for VPS33A Gene

    Size:
    596 amino acids
    Molecular mass:
    67611 Da
    Quaternary structure:
    • Large heterooligomeric complex together with VPS11, VPS16 and VPS18. Interacts with STX7 (By similarity). Interacts with VIPAS39.
    SequenceCaution:
    • Sequence=BAB15570.1; Type=Frameshift; Positions=140; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VPS33A Gene

neXtProt entry for VPS33A Gene

Proteomics data for VPS33A Gene at MOPED

Post-translational modifications for VPS33A Gene

  • Ubiquitination at Lys77, Lys126, Lys316, and Lys335
  • Modification sites at PhosphoSitePlus

Other Protein References for VPS33A Gene

Antibody Products

No data available for DME Specific Peptides for VPS33A Gene

Domains for VPS33A Gene

Protein Domains for VPS33A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for VPS33A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AX1

UniProtKB/Swiss-Prot:

VP33A_HUMAN :
  • Q96AX1
Family:
  • Belongs to the STXBP/unc-18/SEC1 family.
genes like me logo Genes that share domains with VPS33A: view

No data available for Gene Families for VPS33A Gene

Function for VPS33A Gene

Molecular function for VPS33A Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.

Gene Ontology (GO) - Molecular Function for VPS33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19109425
genes like me logo Genes that share ontologies with VPS33A: view
genes like me logo Genes that share phenotypes with VPS33A: view

Animal Model Products

miRNA for VPS33A Gene

miRTarBase miRNAs that target VPS33A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS33A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS33A Gene

Localization for VPS33A Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS33A Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS33A Gene COMPARTMENTS Subcellular localization image for VPS33A gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VPS33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005769 early endosome IDA 19109425
GO:0005770 late endosome IDA 19109425
GO:0030897 colocalizes_with HOPS complex IDA 19109425
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with VPS33A: view

Pathways for VPS33A Gene

SuperPathways for VPS33A Gene

No Data Available

Gene Ontology (GO) - Biological Process for VPS33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IDA 15790593
GO:0030220 platelet formation ISS --
GO:0032400 melanosome localization IDA 15790593
genes like me logo Genes that share ontologies with VPS33A: view

No data available for Pathways by source for VPS33A Gene

Transcripts for VPS33A Gene

mRNA/cDNA for VPS33A Gene

Unigene Clusters for VPS33A Gene

Vacuolar protein sorting 33 homolog A (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS33A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS33A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - -
SP2: - - -
SP3:
SP4:
SP5: - -
SP6:
SP7: - -
SP8:
SP9: -

Relevant External Links for VPS33A Gene

GeneLoc Exon Structure for
VPS33A
ECgene alternative splicing isoforms for
VPS33A

Expression for VPS33A Gene

mRNA expression in normal human tissues for VPS33A Gene

Protein differential expression in normal tissues for VPS33A Gene

This gene is overexpressed in Bone (17.4) and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS33A Gene

SOURCE GeneReport for Unigene cluster for VPS33A Gene Hs.592009

genes like me logo Genes that share expressions with VPS33A: view

Expression partners for VPS33A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS33A Gene

Orthologs for VPS33A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS33A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VPS33A 35
  • 90.6 (n)
  • 97.99 (a)
VPS33A 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia VPS33A 35
  • 90.32 (n)
  • 98.32 (a)
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Vps33a 35
  • 86.91 (n)
  • 97.82 (a)
Vps33a 16
Vps33a 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia VPS33A 35
  • 99.38 (n)
  • 100 (a)
VPS33A 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vps33a 35
  • 86.13 (n)
  • 97.32 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
ManyToMany
-- 36
  • 93 (a)
ManyToMany
chicken
(Gallus gallus)
Aves VPS33A 35
  • 78.79 (n)
  • 91.75 (a)
-- 36
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia vps33a 35
  • 75.13 (n)
  • 86.1 (a)
zebrafish
(Danio rerio)
Actinopterygii vps33a 35
  • 73.29 (n)
  • 84.68 (a)
BX510999.1 36
  • 84 (a)
ManyToMany
vps33a 36
  • 83 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta car 37
  • 43 (a)
car 35
  • 49.43 (n)
  • 45.88 (a)
car 36
  • 44 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003203 35
  • 52.61 (n)
  • 50.85 (a)
worm
(Caenorhabditis elegans)
Secernentea B0303.9 37
  • 25 (a)
vps-33.1 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS33 36
  • 20 (a)
OneToMany
VPS33 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATVPS33 35
  • 47.9 (n)
  • 39.34 (a)
rice
(Oryza sativa)
Liliopsida Os04g0223000 35
  • 49.03 (n)
  • 40.25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13276 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09121 35
  • 47.75 (n)
  • 40.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes vps33 35
  • 45.99 (n)
  • 35.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3653 36
  • 53 (a)
OneToMany
Species with no ortholog for VPS33A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS33A Gene

ENSEMBL:
Gene Tree for VPS33A (if available)
TreeFam:
Gene Tree for VPS33A (if available)

Paralogs for VPS33A Gene

Paralogs for VPS33A Gene

genes like me logo Genes that share paralogs with VPS33A: view

Variants for VPS33A Gene

Sequence variations from dbSNP and Humsavar for VPS33A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs907482 -- 122,262,476(+) CAGAG(A/G)ACTTC intron-variant
rs907483 -- 122,262,593(+) TTAAA(A/T)TTTAA intron-variant
rs1138821 -- 122,231,803(-) CTGGG(A/G)TTACA utr-variant-3-prime
rs1295894 -- 122,248,055(+) ccaaa(C/T)ccagc intron-variant
rs1299217 -- 122,247,940(+) caccc(A/G)ggctg intron-variant

Relevant External Links for VPS33A Gene

HapMap Linkage Disequilibrium report
VPS33A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VPS33A Gene

Disorders for VPS33A Gene

(2) University of Copenhagen DISEASES for VPS33A Gene

genes like me logo Genes that share disorders with VPS33A: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for VPS33A Gene

Publications for VPS33A Gene

  1. Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. (PMID: 15790593) Gissen P. … Maher E.R. (Hum. Mol. Genet. 2005) 3 23
  2. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PMID: 11250079) Huizing M. … Kraemer H. (Gene 2001) 2 3
  3. The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation. (PMID: 12538872) Suzuki T. … Spritz R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery. (PMID: 19109425) Zhu G.D. … L'hernault S.W. (Mol. Biol. Cell 2009) 3 4

Products for VPS33A Gene

Sources for VPS33A Gene

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