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VPS28 Gene

protein-coding   GIFtS: 61
GCID: GC08M145649

Vacuolar Protein Sorting 28 Homolog (S. Cerevisiae)

(Previous name: vacuolar protein sorting 28 (yeast))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 28 Homolog (S. Cerevisiae)1 2
ESCRT-I Complex Subunit VPS282 3
Vacuolar Protein Sorting 28 (Yeast)1
Vacuolar Protein Sorting-Associated Protein 28 Homolog2
Yeast Class E Protein Vps28p Homolog2
H-Vps283

External Ids:    HGNC: 181781   Entrez Gene: 511602   Ensembl: ENSG000001609487   OMIM: 6119525   UniProtKB: Q9UK413   

Export aliases for VPS28 gene to outside databases

Previous GC identifers: GC08M143252 GC08M145686 GC08M145253 GC08M145653 GC08M145620 GC08M145622 GC08M140762


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS28 Gene:
This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which
functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked
to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for VPS28 Gene:
VPS28 (vacuolar protein sorting 28 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS28 include hiv-1, and influenza.

UniProtKB/Swiss-Prot: VPS28_HUMAN, Q9UK41
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process

Gene Wiki entry for VPS28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS28 gene promoter:
         ATF-2   NRSF form 1   NRSF form 2   NF-kappaB   c-Ets-1   GATA-2   PPAR-gamma1   NF-kappaB2   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS28 promoter sequence
   Search Chromatin IP Primers for VPS28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

VPS28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS28 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145649:  view genomic region     (about GC identifiers)

Start:
145,649,000 bp from pter      End:
145,653,931 bp from pter
Size:
4,932 bases      Orientation:
minus strand

1 alternative location:
Chr8-,NW_003315924 192,876-197,803     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VPS28_HUMAN, Q9UK41 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 28 homolog  
Size: 221 amino acids; 25425 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of
TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with
TSG101, VPS37B, VPS37C, MVB12A and MVB12B. Component of an ESCRT-I complex (endosomal sorting complex required
for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Interacts WITH
VPS36; the interaction mediates the association with the ESCRT-II complex. Interacts with SNF8 and VPS25.
Interacts with CEP55
Secondary accessions: Q86VK0
Alternative splicing: 2 isoforms:  Q9UK41-1   Q9UK41-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPS28: NX_Q9UK41

Explore proteomics data for VPS28 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys58
  • Modification sites at PhosphoSitePlus

  • See VPS28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057292.1  NP_898880.1  

    ENSEMBL proteins: 
     ENSP00000434556   ENSP00000433250   ENSP00000434064   ENSP00000433228   ENSP00000433652  
     ENSP00000436102   ENSP00000436509   ENSP00000431243   ENSP00000434393   ENSP00000432395  
     ENSP00000292510   ENSP00000366565  
    Reactome Protein details: Q9UK41

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017898 VPS28_N
     IPR007143 VPS28
     IPR017899 VPS28_C

    Graphical View of Domain Structure for InterPro Entry Q9UK41

    ProtoNet protein and cluster: Q9UK41

    1 Blocks protein domain: IPB007143 Vacuolar protein sorting-associated

    UniProtKB/Swiss-Prot: VPS28_HUMAN, Q9UK41
    Similarity: Belongs to the VPS28 family
    Similarity: Contains 1 VPS28 C-terminal domain
    Similarity: Contains 1 VPS28 N-terminal domain


    VPS28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS28_HUMAN, Q9UK41
    Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    VPS28 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-let-7b-5p (MIRT052309), hsa-mir-328-3p (MIRT043761)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS28_HUMAN, Q9UK41: Cell membrane. Late endosome membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    plasma membrane5
    vacuole2
    cytoskeleton1
    extracellular1
    lysosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000813ESCRT I complex IDA--
    GO:0005737cytoplasm IDA18077552
    GO:0005768endosome IDA11134028
    GO:0005829cytosol IDA11134028
    GO:0005886plasma membrane IEA--

    VPS28 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VPS28 About    
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    Membrane binding and targetting of GAG proteins0.00
    Late Phase of HIV Life Cycle0.91
    Assembly Of The HIV Virion0.00
    HIV Infection0.62
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for VPS28
        Budding and maturation of HIV virion
    Membrane binding and targetting of GAG proteins
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for VPS28):
        Endocytosis


    VPS28 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS28
    Interactions:

        GeneGlobe Interaction Network for VPS28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS28 (Q9UK411, 2, 3 ENSP000003665654) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998161, 2, 3, ENSP000002519684EBI-727424,EBI-346882 MINT-6173737 MINT-6173772 I2D: score=9 STRING: ENSP00000251968
    VPS37BQ9H9H42, 3, ENSP000002672024MINT-6173737 MINT-6173772 I2D: score=3 STRING: ENSP00000267202
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016032viral process TAS--
    GO:0016197endosomal transport TAS--
    GO:0019058viral life cycle TAS--
    GO:0019068virion assembly TAS--

    VPS28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for VPS28



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VPS28 gene (2 alternative transcripts): 
    NM_016208.3  NM_183057.2  

    Unigene Cluster for VPS28:

    Vacuolar protein sorting 28 homolog (S. cerevisiae)
    Hs.418175  [show with all ESTs]
    Unigene Representative Sequence: BC050712
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529182 ENST00000526977 ENST00000526054 ENST00000526204 ENST00000530983
    ENST00000528142 ENST00000530836 ENST00000527797 ENST00000533806 ENST00000531032
    ENST00000531924 ENST00000526734 ENST00000530790 ENST00000524521 ENST00000292510(uc003zcs.1)
    ENST00000377348(uc003zct.1)
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      QuantiTect SYBR Green Assays in human, mouse, rat VPS28
      QuantiFast Probe-based Assays in human, mouse, rat VPS28

    Additional mRNA sequence: 

    AF182844.1 AF316887.1 AK026865.1 AK310062.1 BC006485.1 BC019321.1 BC050712.1 BC050713.2 

    Selected DOTS entries (see all 36):

    DT.75199002  DT.100850481  DT.97802701  DT.95159209  DT.75140456  DT.100672326  DT.97864710  DT.433805 
    DT.100672323  DT.121484289  DT.100672333  DT.121484246  DT.100672339  DT.40315710  DT.91757882  DT.97864713 
    DT.99984654  DT.100672338  DT.121484291  DT.100672321  DT.121484231  DT.121484282  DT.92011321  DT.95159158 

    Selected AceView cDNA sequences (see all 446):

    CD367488 CA308048 AI566174 NM_183057 CR610765 BX379007 BX282132 AA357363 
    AL557782 BM978080 BQ890455 CB161716 CR600507 AV710103 BQ647867 BI765363 
    AI381741 AF182844 BM313826 W95960 AA320915 BQ581773 BM505502 AI445816 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS28 (see all 24)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ·
    SP1:                                            -           -     -     -     -                                               -     -     -     -     -         
    SP2:                                            -           -     -     -     -     -     -                                   -     -     -     -     -         
    SP3:                                            -           -     -     -     -                                               -     -     -     -     -         
    SP4:                                            -           -     -     -     -                                               -     -     -     -     -         
    SP5:                                                                                                                                                            

    ExUns: 8d ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for VPS28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAGCCCG
    VPS28 Expression
    About this image


    VPS28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    VPS28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.418175
        Custom PCR Arrays for VPS28
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS28 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps281 , 5 vacuolar protein sorting 28 (yeast)1, 5 88.08(n)1
    98.64(a)1
      15 (36.17 cM)5
    669141  NM_025842.31  NP_080118.11 
     766220885 
    lizard
    (Anolis carolinensis)
    Reptilia VPS286
    vacuolar protein sorting 28 homolog (S. cerevisiae...
    93(a)
    1 ↔ 1
    GL343892.1(109527-124537)
    African clawed frog
    (Xenopus laevis)
    Amphibia vps28-prov2 vacuolar protein sorting 28 (yeast) 79.25(n)    BC056011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc660782 similar to vacuolar protein sorting 28 82.55(n)   393562  BC056741.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps281 , 3 Vacuolar protein sorting 281 64(a)3
    68.3(n)1
    64.22(a)1
      44A43
    474081  NM_143796.31  NP_652053.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y87G2A.103
    vps-281
    vps-281 46(a)3
    52.26(n)1
    47.24(a)1
      I(13594318-13596874)3
    1732291  NM_060981.51  NP_493382.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS28(YPL065W)4 Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, more   --   16(427927-428655) 856040  NP_015260.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS28-21 VPS28-2 50(n)
    43.23(a)
      825842  NM_116739.3  NP_567281.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g07810001 Os01g0781000 54.8(n)
    41.36(a)
      4327840  NM_001050976.1  NP_001044441.1 


    ENSEMBL Gene Tree for VPS28 (if available)
    TreeFam Gene Tree for VPS28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS28 gene
    1 SIMAP similar gene for VPS28 using alignment to 9 protein entries:     VPS28_HUMAN (see all proteins):
    FP3517

    VPS28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS28 (see all 260)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78426021,2
    C,F,A,H--140765120(+) TCCCCA/GGGGGA 2 -- int16Minor allele frequency- G:0.17NA WA CSA 12
    rs1147242081,2
    F--140765180(+) TCACCT/CGCACA 2 -- int11Minor allele frequency- C:0.04WA 118
    rs175536001,2
    C--140767208(-) GGGGG-/GTCGCC 2 -- us2k10--------
    rs1845430471,2
    --145921488(+) CTGGAA/GCTGCA 2 -- ds50010--------
    rs745685291,2
    C,F--145921565(+) CAGCAT/CGAAGT 2 -- ds50011Minor allele frequency- C:0.25EA 120
    rs1140878621,2
    C,F--145921724(+) GTGGTA/GGACCT 2 -- ds50011Minor allele frequency- G:0.17WA 118
    rs1147178331,2
    F--145921743(+) GGCCTC/TGGGGC 2 -- ds50011Minor allele frequency- T:0.05WA 118
    rs752146491,2
    C,F--145921757(+) GGAAAC/AGCCCC 2 -- ds50011Minor allele frequency- A:0.25EA 120
    rs1466402091,2
    --145921761(+) ACGCCC/TCTGCC 2 -- ds50010--------
    rs1411757811,2
    C--145921765(+) CCCTGC/TCTCCT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for VPS28 (145649000 - 145653931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VPS28 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv907n27CNV Loss19166990
    dgv7966n71CNV Loss21882294
    nsv891841CNV Loss21882294
    dgv7974n71CNV Loss21882294
    nsv891846CNV Loss21882294
    nsv891817CNV Loss21882294
    dgv7967n71CNV Loss21882294
    nsv891807CNV Loss21882294
    dgv7970n71CNV Loss21882294
    nsv891844CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS28
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611952    OMIM disorders: --

    3 diseases for VPS28:    
    About MalaCards
    hiv-1    influenza    malaria


    VPS28 for disorders           About GeneDecksing


    Export disorders for VPS28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS28 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with VPS28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PubMed id 15218037)1, 2, 9 Stuchell M.D.... Sundquist W.I. (J. Biol. Chem. 2004)
    2. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. (PubMed id 18005716)1, 2, 9 Morita E....Sundquist W.I. (Cell Host Microbe 2007)
    3. UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. (PubMed id 21757351)1, 2 Stefani F.... Woodman P. (Curr. Biol. 2011)
    4. Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. (PubMed id 18539118)1, 2 Im Y.J. and Hurley J.H. (Dev. Cell 2008)
    5. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1, 2 Morita E.... Sundquist W.I. (EMBO J. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (Cell 2003)
    8. Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. (PubMed id 11916981)1, 2 Bishop N.... Woodman P. (J. Cell Biol. 2002)
    9. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PubMed id 15509564)1, 9 Eastman S.W.... Bieniasz P.D. (J. Biol. Chem. 2005)
    10. Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover. (PubMed id 16778200)1, 9 Olabisi O.O....Whitehead I.P. (Cancer Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51160 HGNC: 18178 AceView: VPS28 Ensembl:ENSG00000160948 euGenes: HUgn51160
    ECgene: VPS28 Kegg: 51160 H-InvDB: VPS28

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS28 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VPS28 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS28 gene:
    Search GeneIP for patents involving VPS28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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