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Aliases for VPS28 Gene

Aliases for VPS28 Gene

  • Vacuolar Protein Sorting 28 Homolog (S. Cerevisiae) 2 3
  • Vacuolar Protein Sorting 28 (Yeast) 2
  • ESCRT-I Complex Subunit VPS28 4
  • H-Vps28 4

External Ids for VPS28 Gene

Previous GeneCards Identifiers for VPS28 Gene

  • GC08M143252
  • GC08M145686
  • GC08M145253
  • GC08M145653
  • GC08M145620
  • GC08M145622
  • GC08M145649
  • GC08M140762

Summaries for VPS28 Gene

Entrez Gene Summary for VPS28 Gene

  • This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for VPS28 Gene

VPS28 (Vacuolar Protein Sorting 28 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Disease and Endocytosis.

UniProtKB/Swiss-Prot for VPS28 Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process.

Gene Wiki entry for VPS28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS28 Gene

Genomics for VPS28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VPS28 Gene

Start:
144,423,601 bp from pter
End:
144,428,563 bp from pter
Size:
4,963 bases
Orientation:
Minus strand

Genomic View for VPS28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS28 Gene

Proteins for VPS28 Gene

  • Protein details for VPS28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK41-VPS28_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 28 homolog
    Protein Accession:
    Q9UK41
    Secondary Accessions:
    • Q86VK0

    Protein attributes for VPS28 Gene

    Size:
    221 amino acids
    Molecular mass:
    25425 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS37B, VPS37C, MVB12A and MVB12B. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Interacts WITH VPS36; the interaction mediates the association with the ESCRT-II complex. Interacts with SNF8 and VPS25. Interacts with CEP55.

    Alternative splice isoforms for VPS28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS28 Gene

Proteomics data for VPS28 Gene at MOPED

Post-translational modifications for VPS28 Gene

  • Ubiquitination at Lys58
  • Modification sites at PhosphoSitePlus

Other Protein References for VPS28 Gene

Antibody Products

No data available for DME Specific Peptides for VPS28 Gene

Domains for VPS28 Gene

Protein Domains for VPS28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UK41

UniProtKB/Swiss-Prot:

VPS28_HUMAN :
  • Q9UK41
Domain:
  • Contains 1 VPS28 C-terminal domain.
  • Contains 1 VPS28 N-terminal domain.
Family:
  • Belongs to the VPS28 family.
genes like me logo Genes that share domains with VPS28: view

No data available for Gene Families for VPS28 Gene

Function for VPS28 Gene

Molecular function for VPS28 Gene

UniProtKB/Swiss-Prot Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process.

Gene Ontology (GO) - Molecular Function for VPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11134028
GO:0032403 protein complex binding IBA --
GO:0043130 ubiquitin binding IDA 11916981
genes like me logo Genes that share ontologies with VPS28: view

Animal Model Products

CRISPR Products

miRNA for VPS28 Gene

miRTarBase miRNAs that target VPS28

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS28 Gene

Localization for VPS28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS28 Gene

Cell membrane. Late endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS28 Gene COMPARTMENTS Subcellular localization image for VPS28 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 5
vacuole 2
cytoskeleton 1
extracellular 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex IDA 18005716
GO:0005737 cytoplasm IDA 18077552
GO:0005768 endosome IDA 11134028
GO:0005769 early endosome IDA 11916981
GO:0005829 cytosol IDA 11134028
genes like me logo Genes that share ontologies with VPS28: view

Pathways for VPS28 Gene

genes like me logo Genes that share pathways with VPS28: view

Pathways by source for VPS28 Gene

1 KEGG pathway for VPS28 Gene

Gene Ontology (GO) - Biological Process for VPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport --
GO:0016032 viral process TAS --
GO:0016197 endosomal transport TAS --
GO:0019058 viral life cycle TAS --
GO:0019068 virion assembly TAS --
genes like me logo Genes that share ontologies with VPS28: view

Transcripts for VPS28 Gene

Unigene Clusters for VPS28 Gene

Vacuolar protein sorting 28 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS28

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS28 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5:
SP6: - -
SP7: - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - - - - -
SP14: -
SP15: - - - -
SP16: - - - - -
SP17: - - - - - - - - -
SP18: - - - - -
SP19: - - - - -
SP20:
SP21:
SP22: -
SP23:
SP24:

ExUns: 8d ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:
SP24:

Relevant External Links for VPS28 Gene

GeneLoc Exon Structure for
VPS28
ECgene alternative splicing isoforms for
VPS28

Expression for VPS28 Gene

mRNA expression in normal human tissues for VPS28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS28 Gene

SOURCE GeneReport for Unigene cluster for VPS28 Gene Hs.418175

genes like me logo Genes that share expressions with VPS28: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS28 Gene

Orthologs for VPS28 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS28 35
  • 97.35 (n)
  • 97.35 (a)
VPS28 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS28 35
  • 92.76 (n)
  • 98.64 (a)
VPS28 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS28 35
  • 90.2 (n)
  • 97.29 (a)
VPS28 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps28 35
  • 88.08 (n)
  • 98.64 (a)
Vps28 16
Vps28 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia VPS28 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps28 35
  • 88.84 (n)
  • 98.19 (a)
lizard
(Anolis carolinensis)
Reptilia VPS28 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia vps28-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia vps28 35
  • 79.94 (n)
  • 92.31 (a)
zebrafish
(Danio rerio)
Actinopterygii vps28 35
  • 79.39 (n)
  • 88.18 (a)
vps28 36
  • 73 (a)
OneToOne
zgc66078 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005344 35
  • 68.45 (n)
  • 69.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vps28 35
  • 68.3 (n)
  • 64.22 (a)
Vps28 36
  • 53 (a)
OneToOne
Vps28 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea vps-28 35
  • 52.26 (n)
  • 47.24 (a)
vps-28 36
  • 36 (a)
OneToOne
Y87G2A.10 37
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS28 36
  • 24 (a)
OneToOne
VPS28 38
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS28-2 35
  • 50 (n)
  • 43.23 (a)
rice
(Oryza sativa)
Liliopsida Os01g0781000 35
  • 54.8 (n)
  • 41.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3194 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5272 36
  • 49 (a)
OneToOne
Species with no ortholog for VPS28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS28 Gene

ENSEMBL:
Gene Tree for VPS28 (if available)
TreeFam:
Gene Tree for VPS28 (if available)

Paralogs for VPS28 Gene

Selected SIMAP similar genes for VPS28 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with VPS28: view

No data available for Paralogs for VPS28 Gene

Variants for VPS28 Gene

Sequence variations from dbSNP and Humsavar for VPS28 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10527 -- 144,423,802(+) CCCCG(A/G)GCTCA utr-variant-3-prime
rs11948 -- 144,423,755(-) ATGGC(C/T)CCTGG utr-variant-3-prime
rs2272658 -- 144,425,879(-) GGAGC(A/G)AGAGG intron-variant, utr-variant-5-prime
rs2272659 -- 144,424,312(-) CCTCC(C/T)GCACC intron-variant
rs2291130 -- 144,428,167(-) CACCC(C/T)GCGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VPS28 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7967n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7970n71 CNV Loss 21882294
dgv7971n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv7973n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
nsv482124 CNV Gain 20164927
nsv466020 CNV Loss 19166990
dgv7974n71 CNV Loss 21882294
nsv891887 CNV Gain 21882294

Relevant External Links for VPS28 Gene

HapMap Linkage Disequilibrium report
VPS28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS28 Gene

Disorders for VPS28 Gene

No disorders were found for VPS28 Gene.

No data available for UniProtKB/Swiss-Prot for VPS28 Gene

Publications for VPS28 Gene

  1. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PMID: 15218037) Stuchell M.D. … Sundquist W.I. (J. Biol. Chem. 2004) 3 4 23
  2. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. (PMID: 18005716) Morita E. … Sundquist W.I. (Cell Host Microbe 2007) 3 4 23
  3. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PMID: 15509564) Eastman S.W. … Bieniasz P.D. (J. Biol. Chem. 2005) 3 23
  4. The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B. (PMID: 16004603) Katoh K. … Maki M. (Biochem. J. 2005) 3 23
  5. Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover. (PMID: 16778200) Olabisi O.O. … Whitehead I.P. (Cancer Res. 2006) 3 23

Products for VPS28 Gene

  • Addgene plasmids for VPS28

Sources for VPS28 Gene

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