VPS26B Gene
protein-coding GIFtS: 46
GCID: GC11P134094
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|
vacuolar protein sorting 26 homolog B (S. pombe)(Previous name: vacuolar protein sorting 26 homolog B (yeast) )
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Aliases
for VPS26B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vacuolar Protein Sorting 26 Homolog B (S. Pombe)1 2 | | Pep8b1 2 | | Vesicle Protein Sorting 26B2 3 | | MGC104851 | | Vacuolar Protein Sorting 26 Homolog B (Yeast)1 | | Vacuolar Protein Sorting-Associated Protein 26B2 |
Export aliases for VPS26B gene to outside databasesPrevious GC identifers: GC11P133600 GC11P130050 |
Summaries
for VPS26B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: VP26B_HUMAN, Q4G0F5Function: Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2Rand M6PR) from endosomes to the trans-Golgi network (By similarity)
|
Genomic Views
for VPS26B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VPS26B gene promoter:
AML1a MAZR Pax-2 Pax-2a HNF-4alpha2 HNF-4alpha1 AREB6 POU2F1 POU2F1a MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for VPS26B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS26B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q25 Ensembl cytogenetic band: 11q25 HGNC cytogenetic band: 11q25VPS26B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P134094: view genomic region
(about GC identifiers)
Start:
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134,094,539 bp from pter |
End:
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134,117,686 bp from pter |
Size:
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23,148 bases |
Orientation:
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plus strand |
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Proteins
for VPS26B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VP26B_HUMAN, Q4G0F5 (See
protein sequence)Recommended Name: Vacuolar protein sorting-associated protein 26B Size: 336 amino acids; 39155 Da
Subunit: Probable component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2.Interacts directly with VPS35 (By similarity)
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Does not localize to endosomes (Bysimilarity)
Secondary accessions: Q96A55Explore the universe of human proteins at neXtProt for VPS26B: NX_Q4G0F5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4G0F5
VPS26B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443107.1
ENSEMBL proteins: ENSP00000281187 ENSP00000434162 ENSP00000431672
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
VPS26B for ontologies About GeneDecksing
VPS26B Antibody Products:
Assay Products for VPS26B: |
Protein
Domains /
Families
for VPS26B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VPS26B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q4G0F5ProtoNet protein and cluster: Q4G0F5 1 Blocks protein family: IPB005377 Vacuolar protein sorting-associated protein 26
UniProtKB/Swiss-Prot: VP26B_HUMAN, Q4G0F5Similarity: Belongs to the VPS26 family |
Function
for VPS26B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VP26B_HUMAN, Q4G0F5Function: Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2Rand M6PR) from endosomes to the trans-Golgi network (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS26B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS26B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for VPS26B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS26B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS26B |
Animal Models:
Mouse knock-out Vps26btm1Ktch for VPS26B
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Vps26b):
VPS26B for phenotypes About GeneDecksing
|
Pathways & Interactions
for VPS26B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS26B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/41 Interacting proteins for VPS26B (Q4G0F53 ENSP000002811874) via UniProtKB, MINT, STRING, and/or I2D (see all 41)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007034 | vacuolar transport |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
VPS26B for ontologies About GeneDecksing
|
Drugs & Compounds
for VPS26B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VPS26B
Search CenterWatch for drugs/clinical trials and news about VPS26B / VP26B
|
Transcripts
for VPS26B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VPS26B gene: NM_052875.3 Unigene Cluster for VPS26B: Vacuolar protein sorting 26 homolog B (S. pombe) Hs.334684 [show with all ESTs]Unigene Representative Sequence: BC0983867 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000281187(uc001qhe.3) ENST00000525095 ENST00000527586 ENST00000532160
ENST00000530402 ENST00000525918 ENST00000531741
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS26B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS26B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VPS26B (NM_052875) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS26B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS26B |
Additional cDNA sequence: AF452718.1 BC007799.2 BC009747.2 BC013255.1 BC014128.2 BC098386.1 11 DOTS entries: DT.455754 DT.92034404 DT.92440439 DT.95301984 DT.95206460 DT.92343591 DT.101974762 DT.75133693 DT.95206457 DT.95206459 DT.215804 24/313 AceView cDNA sequences (see all 313): AA883407 BU521062 AI567985 AI797082 AW954299 BQ711359 AI460220 AF452718 BM835979 BQ640523 CA310768 N34950 BF507926 Z40181 AI886845 CA430766 AA253084 BC014128 CR621034 BU528804 CR625768 BQ672086 CA431265 AA983450
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for VPS26B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for VPS26B
|
Expression
for VPS26B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VPS26B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTTAATG
About this image
See VPS26B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VPS26B
SOURCE GeneReport for Unigene cluster: Hs.334684
SABiosciences Custom PCR Arrays for VPS26B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS26B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS26B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS26B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS26B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS26B |
Orthologs
for VPS26B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for VPS26B gene from 8/31 species (see all 31) About this table
ENSEMBL Gene Tree for VPS26B (if available)
TreeFam Gene Tree for VPS26B (if available) |
Paralogs
for VPS26B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VPS26B gene
- VPS26A2
1 SIMAP similar gene for VPS26B using alignment to 3 protein entries: VP26B_HUMAN (see all proteins):VPS26A
VPS26B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for VPS26B
PGOHUM00000237617
|
Genomic Variants
for VPS26B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VPS26B (134094539 - 134117686 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for VPS26B
1 CNV: 4764 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS26B |
|
Disorders
/ Diseases
for VPS26B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VPS26B for disorders About GeneDecksing
OMIM gene information: 610027
OMIM disorders: --
1  disease for VPS26B: About MalaCardsmalaria
Export disorders for VPS26B gene to outside databases
|
Publications
for VPS26B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VPS26B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with VPS26B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel mammalian retromer component, Vps26B. (PubMed id 16190980)1, 3 Kerr M.C.... Teasdale R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Rab GTPase-activating proteins in autophagy: regulatio n of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (2012)
- Vps26A and Vps26B subunits define distinct retromer co mplexes. (PubMed id 21920005)1 Bugarcic A....Teasdale R.D. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for VPS26B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VPS26B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VPS26B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VPS26B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VPS26B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VPS26B gene:
Search GeneIP for patents involving VPS26B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VPS26B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VPS26B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS26B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS26B | | | OriGene Protein Over-expression Lysate for VPS26B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VPS26B | | OriGene 3'-UTR Clone for VPS26B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS26B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS26B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VPS26B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VPS26B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS26B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS26B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS26B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS26B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS26B |
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| | | | Search Tocris compounds for VPS26B |
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 | | | VPS26B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS26B |
|  |  |  | | | | Search ThermoFisher Antibodies for VPS26B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS26B |
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