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Aliases for VPS26B Gene

Aliases for VPS26B Gene

  • VPS26 Retromer Complex Component B 2 3
  • Vesicle Protein Sorting 26B 3 4
  • Vacuolar Protein Sorting 26 Homolog B (S. Pombe) 2
  • Vacuolar Protein Sorting 26 Homolog B (Yeast) 2
  • Pep8b 3

External Ids for VPS26B Gene

Previous GeneCards Identifiers for VPS26B Gene

  • GC11P133600
  • GC11P134094
  • GC11P130050

Summaries for VPS26B Gene

GeneCards Summary for VPS26B Gene

VPS26B (VPS26 Retromer Complex Component B) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is VPS26A.

UniProtKB/Swiss-Prot for VPS26B Gene

  • Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS26B Gene

Genomics for VPS26B Gene

Regulatory Elements for VPS26B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VPS26B Gene

Chromosome:
11
Start:
134,224,605 bp from pter
End:
134,247,792 bp from pter
Size:
23,188 bases
Orientation:
Plus strand

Genomic View for VPS26B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS26B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS26B Gene

Proteins for VPS26B Gene

  • Protein details for VPS26B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0F5-VP26B_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 26B
    Protein Accession:
    Q4G0F5
    Secondary Accessions:
    • Q96A55

    Protein attributes for VPS26B Gene

    Size:
    336 amino acids
    Molecular mass:
    39155 Da
    Quaternary structure:
    • Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting VPS subcomplex (VPS,) formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform. The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex. Interacts with VPS29, VPS35, TBC1D5, GOLPH3, SNX27 (By similarity).

neXtProt entry for VPS26B Gene

Proteomics data for VPS26B Gene at MOPED

Post-translational modifications for VPS26B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPS26B Gene

Antibody Products

No data available for DME Specific Peptides for VPS26B Gene

Domains & Families for VPS26B Gene

Protein Domains for VPS26B Gene

Suggested Antigen Peptide Sequences for VPS26B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0F5

UniProtKB/Swiss-Prot:

VP26B_HUMAN :
  • Belongs to the VPS26 family.
Family:
  • Belongs to the VPS26 family.
genes like me logo Genes that share domains with VPS26B: view

No data available for Gene Families for VPS26B Gene

Function for VPS26B Gene

Molecular function for VPS26B Gene

UniProtKB/Swiss-Prot Function:
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

Gene Ontology (GO) - Molecular Function for VPS26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with VPS26B: view

Phenotypes for VPS26B Gene

genes like me logo Genes that share phenotypes with VPS26B: view

Animal Models for VPS26B Gene

MGI Knock Outs for VPS26B:

Animal Model Products

miRNA for VPS26B Gene

miRTarBase miRNAs that target VPS26B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS26B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for VPS26B Gene

Localization for VPS26B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS26B Gene

Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Late endosome. Note=Localizes to early and late endosomal structures (By similarity). {ECO:0000250 UniProtKB:Q8C0E2}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS26B Gene COMPARTMENTS Subcellular localization image for VPS26B gene
Compartment Confidence
cytosol 4
endosome 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for VPS26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005769 early endosome ISS --
GO:0005770 late endosome ISS --
GO:0005829 cytosol ISS 11102511
GO:0030904 retromer complex ISS --
genes like me logo Genes that share ontologies with VPS26B: view

Pathways & Interactions for VPS26B Gene

SuperPathways for VPS26B Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with VPS26B: view

Pathways by source for VPS26B Gene

1 KEGG pathway for VPS26B Gene

Gene Ontology (GO) - Biological Process for VPS26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0042147 retrograde transport, endosome to Golgi NAS 26220253
genes like me logo Genes that share ontologies with VPS26B: view

No data available for SIGNOR curated interactions for VPS26B Gene

Drugs & Compounds for VPS26B Gene

No Compound Related Data Available

Transcripts for VPS26B Gene

Unigene Clusters for VPS26B Gene

Vacuolar protein sorting 26 homolog B (S. pombe):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS26B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS26B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: - - - -
SP4:

Relevant External Links for VPS26B Gene

GeneLoc Exon Structure for
VPS26B
ECgene alternative splicing isoforms for
VPS26B

Expression for VPS26B Gene

mRNA expression in normal human tissues for VPS26B Gene

Protein differential expression in normal tissues from HIPED for VPS26B Gene

This gene is overexpressed in Frontal cortex (7.0) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS26B Gene



SOURCE GeneReport for Unigene cluster for VPS26B Gene Hs.334684

genes like me logo Genes that share expression patterns with VPS26B: view

Protein tissue co-expression partners for VPS26B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS26B Gene

Orthologs for VPS26B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS26B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VPS26B 35
  • 87.9 (n)
  • 95.54 (a)
VPS26B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS26B 35
  • 93.07 (n)
  • 98.7 (a)
VPS26B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps26b 35
  • 92.46 (n)
  • 99.11 (a)
Vps26b 16
Vps26b 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VPS26B 35
  • 99.5 (n)
  • 100 (a)
VPS26B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps26b 35
  • 91.77 (n)
  • 99.11 (a)
oppossum
(Monodelphis domestica)
Mammalia VPS26B 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS26B 35
  • 82.24 (n)
  • 92.56 (a)
VPS26B 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS26B 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps26b 35
  • 78.3 (n)
  • 93.4 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.4181 35
vps26b 36
  • 85 (a)
OneToMany
vps26bl 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Vps26 35
  • 70.82 (n)
  • 72.13 (a)
Vps26 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-26 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP8 36
  • 34 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2754 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2076 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2536 36
  • 63 (a)
OneToMany
Species with no ortholog for VPS26B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS26B Gene

ENSEMBL:
Gene Tree for VPS26B (if available)
TreeFam:
Gene Tree for VPS26B (if available)

Paralogs for VPS26B Gene

Paralogs for VPS26B Gene

(1) SIMAP similar genes for VPS26B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for VPS26B Gene

genes like me logo Genes that share paralogs with VPS26B: view

Variants for VPS26B Gene

Sequence variations from dbSNP and Humsavar for VPS26B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11384 -- 134,247,610(+) CTCCC(A/G)GGTTT utr-variant-3-prime
rs12180 -- 134,246,231(+) CCTGT(A/G)GGATG utr-variant-3-prime
rs13982 -- 134,247,354(+) AGCTG(A/G)TATTC utr-variant-3-prime
rs475208 -- 134,231,884(-) TCAGC(A/C)AAGCA intron-variant
rs492761 -- 134,247,121(+) CATTT(C/T)GGGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VPS26B Gene

Variant ID Type Subtype PubMed ID
nsv521581 CNV Gain 19592680
nsv832299 CNV Loss 17160897
nsv898474 CNV Loss 21882294
nsv826147 CNV Gain 20364138
esv2745323 CNV Deletion 23290073
nsv898475 CNV Gain 21882294

Variation tolerance for VPS26B Gene

Residual Variation Intolerance Score: 14.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS26B Gene

HapMap Linkage Disequilibrium report
VPS26B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS26B Gene

Disorders for VPS26B Gene

Relevant External Links for VPS26B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS26B
genes like me logo Genes that share disorders with VPS26B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS26B Gene

Publications for VPS26B Gene

  1. Vps26A and Vps26B subunits define distinct retromer complexes. (PMID: 21920005) Bugarcic A. … Teasdale R.D. (Traffic 2011) 2 67
  2. A novel mammalian retromer component, Vps26B. (PMID: 16190980) Kerr M.C. … Teasdale R.D. (Traffic 2005) 2 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for VPS26B Gene

Sources for VPS26B Gene

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