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Aliases for VPS26B Gene

Aliases for VPS26B Gene

  • Vacuolar Protein Sorting 26 Homolog B (S. Pombe) 2 3
  • Vesicle Protein Sorting 26B 3 4
  • Vacuolar Protein Sorting-Associated Protein 26B 3
  • Vacuolar Protein Sorting 26 Homolog B (Yeast) 2
  • Pep8b 3

External Ids for VPS26B Gene

Previous GeneCards Identifiers for VPS26B Gene

  • GC11P133600
  • GC11P134094
  • GC11P130050

Summaries for VPS26B Gene

GeneCards Summary for VPS26B Gene

VPS26B (Vacuolar Protein Sorting 26 Homolog B (S. Pombe)) is a Protein Coding gene. An important paralog of this gene is VPS26A.

UniProtKB/Swiss-Prot for VPS26B Gene

  • Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS26B Gene

Genomics for VPS26B Gene

Regulatory Elements for VPS26B Gene

Genomic Location for VPS26B Gene

Start:
134,224,645 bp from pter
End:
134,247,792 bp from pter
Size:
23,148 bases
Orientation:
Plus strand

Genomic View for VPS26B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS26B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS26B Gene

Proteins for VPS26B Gene

  • Protein details for VPS26B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0F5-VP26B_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 26B
    Protein Accession:
    Q4G0F5
    Secondary Accessions:
    • Q96A55

    Protein attributes for VPS26B Gene

    Size:
    336 amino acids
    Molecular mass:
    39155 Da
    Quaternary structure:
    • Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting VPS subcomplex (VPS,) formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform. The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex. Interacts with VPS29, VPS35, TBC1D5, GOLPH3, SNX27 (By similarity).

neXtProt entry for VPS26B Gene

Proteomics data for VPS26B Gene at MOPED

Post-translational modifications for VPS26B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPS26B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPS26B Gene

Domains for VPS26B Gene

Protein Domains for VPS26B Gene

Suggested Antigen Peptide Sequences for VPS26B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0F5

UniProtKB/Swiss-Prot:

VP26B_HUMAN :
  • Q4G0F5
Family:
  • Belongs to the VPS26 family.
genes like me logo Genes that share domains with VPS26B: view

No data available for Gene Families for VPS26B Gene

Function for VPS26B Gene

Molecular function for VPS26B Gene

UniProtKB/Swiss-Prot Function: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

Gene Ontology (GO) - Molecular Function for VPS26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with VPS26B: view

Phenotypes for VPS26B Gene

genes like me logo Genes that share phenotypes with VPS26B: view

Animal Models for VPS26B Gene

MGI Knock Outs for VPS26B:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for VPS26B Gene

Localization for VPS26B Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS26B Gene

Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Late endosome. Note=Localizes to early and late endosomal structures (By similarity). {ECO:0000250 UniProtKB:Q8C0E2}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS26B Gene COMPARTMENTS Subcellular localization image for VPS26B gene
Compartment Confidence
cytosol 4
endosome 2
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPS26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005769 early endosome ISS --
GO:0005770 late endosome ISS --
GO:0005829 cytosol ISS 11102511
GO:0016020 membrane --
genes like me logo Genes that share ontologies with VPS26B: view

Pathways for VPS26B Gene

SuperPathways for VPS26B Gene

No Data Available

Gene Ontology (GO) - Biological Process for VPS26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0015031 protein transport --
GO:0042147 retrograde transport, endosome to Golgi ISS --
genes like me logo Genes that share ontologies with VPS26B: view

No data available for Pathways by source for VPS26B Gene

Transcripts for VPS26B Gene

Unigene Clusters for VPS26B Gene

Vacuolar protein sorting 26 homolog B (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS26B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: - - - -
SP4:

Relevant External Links for VPS26B Gene

GeneLoc Exon Structure for
VPS26B
ECgene alternative splicing isoforms for
VPS26B

Expression for VPS26B Gene

mRNA expression in normal human tissues for VPS26B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS26B Gene

SOURCE GeneReport for Unigene cluster for VPS26B Gene Hs.334684

genes like me logo Genes that share expressions with VPS26B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VPS26B Gene

Orthologs for VPS26B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS26B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS26B 35
  • 99.5 (n)
  • 100 (a)
VPS26B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS26B 35
  • 87.9 (n)
  • 95.54 (a)
VPS26B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS26B 35
  • 93.07 (n)
  • 98.7 (a)
VPS26B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps26b 35
  • 92.46 (n)
  • 99.11 (a)
Vps26b 16
Vps26b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS26B 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps26b 35
  • 91.77 (n)
  • 99.11 (a)
chicken
(Gallus gallus)
Aves VPS26B 35
  • 82.24 (n)
  • 92.56 (a)
VPS26B 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS26B 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps26b 35
  • 78.3 (n)
  • 93.4 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.4181 35
vps26b 36
  • 85 (a)
OneToMany
vps26bl 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Vps26 35
  • 70.82 (n)
  • 72.13 (a)
Vps26 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-26 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP8 36
  • 34 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2754 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2076 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2536 36
  • 63 (a)
OneToMany
Species with no ortholog for VPS26B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS26B Gene

ENSEMBL:
Gene Tree for VPS26B (if available)
TreeFam:
Gene Tree for VPS26B (if available)

Paralogs for VPS26B Gene

Paralogs for VPS26B Gene

Selected SIMAP similar genes for VPS26B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for VPS26B Gene

genes like me logo Genes that share paralogs with VPS26B: view

Variants for VPS26B Gene

Sequence variations from dbSNP and Humsavar for VPS26B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11384 -- 134,247,610(-) CTCCC(A/G)GGTTT utr-variant-3-prime
rs12180 -- 134,246,231(+) CCTGT(A/G)GGATG utr-variant-3-prime
rs13982 -- 134,247,354(+) AGCTG(A/G)TATTC utr-variant-3-prime
rs475208 -- 134,231,884(-) TCAGC(A/C)AAGCA intron-variant
rs500150 -- 134,231,865(-) CCTCC(A/C)AAggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS26B Gene

Variant ID Type Subtype PubMed ID
nsv521581 CNV Gain 19592680
nsv832299 CNV Loss 17160897
nsv898474 CNV Loss 21882294
nsv826147 CNV Gain 20364138
esv2745323 CNV Deletion 23290073
nsv898475 CNV Gain 21882294

Relevant External Links for VPS26B Gene

HapMap Linkage Disequilibrium report
VPS26B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS26B Gene

Disorders for VPS26B Gene

No disorders were found for VPS26B Gene.

No data available for UniProtKB/Swiss-Prot for VPS26B Gene

Publications for VPS26B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A novel mammalian retromer component, Vps26B. (PMID: 16190980) Kerr M.C. … Teasdale R.D. (Traffic 2005) 2 3
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Vps26A and Vps26B subunits define distinct retromer complexes. (PMID: 21920005) Bugarcic A. … Teasdale R.D. (Traffic 2011) 3
  5. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PMID: 22354992) Popovic D. … Dikic I. (Mol. Cell. Biol. 2012) 3

Products for VPS26B Gene

Sources for VPS26B Gene

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