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VPS26A Gene

protein-coding   GIFtS: 60
GCID: GC10P070885

Vacuolar Protein Sorting 26 Homolog A (S. Pombe)

(Previous names: vacuolar protein sorting 26 (yeast homolog), vacuolar protein...)
(Previous symbol: VPS26)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 26 Homolog A (S. Pombe)1 2     Vacuolar Protein Sorting 26 Homolog A (Yeast)1
VPS261 2 3 5     Hbeta582
Vesicle Protein Sorting 26A2 3     PEP8A2
HB582 5     Vacuolar Protein Sorting-Associated Protein 26A2
Vacuolar Protein Sorting 26 (Yeast Homolog)1     hVPS263
Vacuolar Protein Sorting 26 (Yeast)1     

External Ids:    HGNC: 127111   Entrez Gene: 95592   Ensembl: ENSG000001229587   OMIM: 6055065   UniProtKB: O754363   

Export aliases for VPS26A gene to outside databases

Previous GC identifers: GC10P070556 GC10P064883


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS26A Gene:
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a
large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from
endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that
make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate
that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative
splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for VPS26A Gene:
VPS26A (vacuolar protein sorting 26 homolog A (S. pombe)) is a protein-coding gene. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is VPS26B.

UniProtKB/Swiss-Prot: VP26A_HUMAN, O75436
Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors
(IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the
polymeric immunoglobulin receptor (pIgR-pIgA)

Gene Wiki entry for VPS26A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS26A gene promoter:
         USF1   AML1a   FOXO3   FOXO3b   N-Myc   Egr-2   POU2F1   POU2F1a   USF-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS26A promoter sequence
   Search Chromatin IP Primers for VPS26A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS26A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21.1

VPS26A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS26A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070885:  view genomic region     (about GC identifiers)

Start:
70,883,268 bp from pter      End:
70,932,617 bp from pter
Size:
49,350 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VP26A_HUMAN, O75436 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 26A  
Size: 327 amino acids; 38170 Da
Subunit: Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2.
Interacts directly with VPS35. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.
Interacts with ECM29
1 PDB 3D structure from and Proteopedia for VPS26A:
2FAU (3D)    
Secondary accessions: A8MZ56 B2RDD3 Q8TBH4 Q9H982
Alternative splicing: 2 isoforms:  O75436-1   O75436-2   (No experimental confirmation available. Ref.6 (BQ048905) sequence is in conflict in position: 243:G->R)

Explore the universe of human proteins at neXtProt for VPS26A: NX_O75436

Explore proteomics data for VPS26A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys242
  • Modification sites at PhosphoSitePlus

  • See VPS26A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001030337.1  NP_004887.2  

    ENSEMBL proteins: 
     ENSP00000362480   ENSP00000473746   ENSP00000474611   ENSP00000263559   ENSP00000378532  
     ENSP00000446081   ENSP00000442705  
    Reactome Protein details: O75436

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005377 VPS26

    Graphical View of Domain Structure for InterPro Entry O75436

    ProtoNet protein and cluster: O75436

    1 Blocks protein domain: IPB005377 Vacuolar protein sorting-associated protein 26

    UniProtKB/Swiss-Prot: VP26A_HUMAN, O75436
    Similarity: Belongs to the VPS26 family


    Find genes that share domains with VPS26A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VP26A_HUMAN, O75436
    Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors
    (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the
    polymeric immunoglobulin receptor (pIgR-pIgA)
    Induction: Down-regulated in Alzheimer disease. No polymorphism or variant is however associated with Alzheimer
    disease for VPS26A

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11102511
    GO:0008565protein transporter activity NAS11102511
         
    Find genes that share ontologies with VPS26A           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vps26a):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  mortality/aging 
     nervous system  normal 

    Find genes that share phenotypes with VPS26A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vps26atm1Cos for VPS26A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS26A
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    miRNA
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    miRTarBase miRNAs that target VPS26A:
    hsa-mir-21-5p (MIRT031005), hsa-mir-7-5p (MIRT025885), hsa-mir-373-3p (MIRT004448)

    Block miRNA regulation of human, mouse, rat VPS26A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS26A (see all 25):
    hsa-miR-485-5p hsa-miR-548j hsa-miR-607 hsa-miR-3200-5p hsa-miR-548i hsa-miR-374a* hsa-miR-1304 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidVPS26A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS26A

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    Addgene plasmids for VPS26A 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VP26A_HUMAN, O75436: Cytoplasm. Endosome membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA--
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane IEA--
    GO:0030904retromer complex ----
    GO:0031982vesicle IDA--

    Find genes that share ontologies with VPS26A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VPS26A About    
    See pathways by source

    SuperPathContained pathways About
    1beta-catenin independent WNT signaling
    Signaling by Wnt0.79
    2Signaling by GPCR
    Signal Transduction0.58
    3Wnt Pathway
    WNT ligand biogenesis and trafficking0.56


    Find genes that share SuperPaths with VPS26A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for VPS26A
        WNT ligand biogenesis and trafficking


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS26A
    Interactions:

        GeneGlobe Interaction Network for VPS26A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS26A (O754363 ENSP000002635594) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ILKQ134183, ENSP000002994214I2D: score=1 STRING: ENSP00000299421
    SMYD2Q9NRG43, ENSP000003559244I2D: score=1 STRING: ENSP00000355924
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007034vacuolar transport ----
    GO:0042147retrograde transport, endosome to Golgi NAS11102511

    Find genes that share ontologies with VPS26A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS26A (VP26A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS26A gene (2 alternative transcripts): 
    NM_001035260.1  NM_004896.3  

    Unigene Cluster for VPS26A:

    Vacuolar protein sorting 26 homolog A (S. pombe)
    Hs.499925  [show with all ESTs]
    Unigene Representative Sequence: BX647725
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373382(uc001jpb.3 uc001jpc.3 uc009xqa.3 uc001jpd.3)
    ENST00000489656 ENST00000497564 ENST00000490696 ENST00000467852 ENST00000489794
    ENST00000497022 ENST00000263559 ENST00000395098 ENST00000546041 ENST00000541711

    miRNA
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    Block miRNA regulation of human, mouse, rat VPS26A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS26A (see all 25):
    hsa-miR-485-5p hsa-miR-548j hsa-miR-607 hsa-miR-3200-5p hsa-miR-548i hsa-miR-374a* hsa-miR-1304 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidVPS26A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS26A
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): VPS26A (NM_001035260)
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    Addgene plasmids for VPS26A 
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      QuantiTect SYBR Green Assays in human, mouse, rat VPS26A
      QuantiFast Probe-based Assays in human, mouse, rat VPS26A

    Additional mRNA sequence: 

    AF054179.1 AF175266.1 AK022992.1 AK290536.1 AK297142.1 AK309021.1 AK315496.1 AL110166.1 
    BC022505.1 BC131761.1 BX647725.1 BX649092.1 

    21 DOTS entries:

    DT.455635  DT.100813062  DT.100813060  DT.92471418  DT.97864257  DT.92471474  DT.101983549  DT.121249244 
    DT.121249220  DT.95234375  DT.100041970  DT.121249237  DT.92471446  DT.95234376  DT.100041971  DT.100651254 
    DT.100801167  DT.100801491  DT.102825661  DT.121249253  DT.207859 

    Selected AceView cDNA sequences (see all 332):

    BQ008665 CR618440 BX097619 BM142665 BP360707 AA885350 BM054795 BM798661 
    BM843312 AA745931 AI687383 AI591371 BF439803 AW262896 CB156996 AI561025 
    BP369104 BU633615 BM855868 BM670880 AI431406 AI214338 BM740310 BQ876924 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS26A (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                -                                               -         
    SP2:                                -     -                                         -         
    SP3:        -     -     -           -                                                         
    SP4:                                -     -     -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for VPS26A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS26A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTATAATA
    VPS26A Expression
    About this image


    VPS26A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
    VPS26A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS26A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499925
        Custom PCR Arrays for VPS26A
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat VPS26A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS26A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS26A gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps26a1 , 5 vacuolar protein sorting 26 homolog A (yeast)1, 5 91.1(n)1
    99.08(a)1
      10 (32.41 cM)5
    309301  NM_001113355.11  NP_001106826.11 
     624548435 
    chicken
    (Gallus gallus)
    Aves VPS26A1 vacuolar protein sorting 26 homolog A (S. pombe) 86.61(n)
    96.63(a)
      423696  XM_421577.4  XP_421577.2 
    lizard
    (Anolis carolinensis)
    Reptilia VPS26A6
    vacuolar protein sorting 26 homolog A (S. pombe)
    88(a)
    1 ↔ 1
    GL343215.1(1993863-2005644)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.50052 Xenopus laevis transcribed sequence with strong similarity more 80.76(n)    BX854783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc566732 similar to vacuolar protein sorting 26 (yeast) 78.48(n)   393881  AY391469.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps266
    Vacuolar protein sorting 26
    42(a)
    1 → many
    X(1767896-1770514)
    worm
    (Caenorhabditis elegans)
    Secernentea vps-266
    Protein VPS-26, isoform a
    47(a)
    1 → many
    IV(9339400-9341790) WBGene00006931
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP8(YJL053W)4 Vacuolar protein sorting protein that forms part of more   --   10(335898-337037) 853393  NP_012482.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS26B1 VPS26B 58.87(n)
    59.66(a)
      828883  NM_118908.4  NP_194499.2 
    rice
    (Oryza sativa)
    Liliopsida Os.211582 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.33(n)    AK065196.1 


    ENSEMBL Gene Tree for VPS26A (if available)
    TreeFam Gene Tree for VPS26A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS26A gene
    VPS26B2  
    1 SIMAP similar gene for VPS26A using alignment to 5 protein entries:     VP26A_HUMAN (see all proteins):
    VPS26B

    Find genes that share paralogs with VPS26A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for VPS26A
    PGOHUM00000238136


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS26A (see all 1071)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837958861,2
    --70881965(+) CTAGTA/GTGACT 2 -- us2k10--------
    rs348773341,2
    --70882048(+) CTTTGC/G/TTATGT 2 -- us2k10--------
    rs1130280841,2
    C--70882064(+) TTTAAG/ATCCCA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs340958721,2
    C,F--70882252(+) GGAGTG/CTCGCT 2 -- us2k13Minor allele frequency- C:0.33NA 6
    rs122639591,2
    --70882299(+) ctcacA/Tgcaat 2 -- us2k1 tfbs30--------
    rs47468171,2
    C,F,H--70882515(+) caccaC/Tgcctg 2 -- us2k122Minor allele frequency- T:0.21NS EA NA WA CSA 2332
    rs1932811601,2
    --70882574(+) CACTGC/GATTCC 2 -- us2k10--------
    rs1854398061,2
    --70882648(+) TTTTTG/TAGACA 2 -- us2k10--------
    rs115958791,2
    C,F,H--70882713(+) AACCTC/TCGCTT 2 -- us2k15Minor allele frequency- T:0.08NA EA 250
    rs732725871,2
    C,F--70882729(+) ATTCAA/GGAGAT 2 -- us2k13Minor allele frequency- G:0.18WA CSA 122

    HapMap Linkage Disequilibrium report for VPS26A (70883268 - 70932617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VPS26A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7010CNV Loss18451855
    nsv508589CNV Loss20534489
    nsv819970CNV Loss19587683
    nsv895694CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS26A
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS26A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605506    OMIM disorders: --


    Find genes that share disorders with VPS26A           About GenesLikeMe

    Genetic Association Database (GAD): VPS26A
    Human Genome Epidemiology (HuGE) Navigator: VPS26A (2 documents)

    Export disorders for VPS26A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS26A gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with VPS26A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. (PubMed id 16784798)1, 2, 4, 9 Riemenschneider M.... Forstl H. (Neurobiol. Aging 2007)
    2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. (PubMed id 16732284)1, 2, 9 Shi H.... Hurley J.H. (Nat. Struct. Mol. Biol. 2006)
    4. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PubMed id 21874001)1, 4 Kooner J.S....Chambers J.C. (Nat. Genet. 2011)
    5. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (J. Biol. Chem. 2010)
    6. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. (PubMed id 16407403)1, 2 Gullapalli A.... Trejo J. (Mol. Biol. Cell 2006)
    7. Model-guided microarray implicates the retromer complex in Alzheimer's disease. (PubMed id 16315276)1, 2 Small S.A.... Kim T.-W. (Ann. Neurol. 2005)
    8. A novel mammalian retromer component, Vps26B. (PubMed id 16190980)1, 2 Kerr M.C.... Teasdale R.D. (Traffic 2005)
    9. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. (PubMed id 15247922)1, 2 Verges M.... Mostov K.E. (Nat. Cell Biol. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9559 HGNC: 12711 AceView: VPS26 Ensembl:ENSG00000122958 euGenes: HUgn9559
    ECgene: VPS26A H-InvDB: VPS26A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS26A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS26A gene:
    Search GeneIP for patents involving VPS26A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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