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Aliases for VPS26A Gene

Aliases for VPS26A Gene

  • Vacuolar Protein Sorting 26 Homolog A (S. Pombe) 2 3
  • VPS26 3 4 6
  • Vesicle Protein Sorting 26A 3 4
  • HB58 3 6
  • Vacuolar Protein Sorting-Associated Protein 26A 3
  • Vacuolar Protein Sorting 26 Homolog A (Yeast) 2
  • Vacuolar Protein Sorting 26 (Yeast Homolog) 2
  • Vacuolar Protein Sorting 26 (Yeast) 2
  • Hbeta58 3
  • HVPS26 4
  • PEP8A 3

External Ids for VPS26A Gene

Previous Symbols for VPS26A Gene

  • VPS26

Summaries for VPS26A Gene

Entrez Gene Summary for VPS26A Gene

  • This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for VPS26A Gene

VPS26A (Vacuolar Protein Sorting 26 Homolog A (S. Pombe)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and beta-catenin independent WNT signaling. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is VPS26B.

UniProtKB/Swiss-Prot for VPS26A Gene

  • Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of FAM21A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).

Gene Wiki entry for VPS26A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS26A Gene

Genomics for VPS26A Gene

Genomic Location for VPS26A Gene

Start:
69,123,512 bp from pter
End:
69,172,861 bp from pter
Size:
49,350 bases
Orientation:
Plus strand

Genomic View for VPS26A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS26A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS26A Gene

Regulatory Elements for VPS26A Gene

Proteins for VPS26A Gene

  • Protein details for VPS26A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75436-VP26A_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 26A
    Protein Accession:
    O75436
    Secondary Accessions:
    • A8MZ56
    • B2RDD3
    • Q8TBH4
    • Q9H982

    Protein attributes for VPS26A Gene

    Size:
    327 amino acids
    Molecular mass:
    38170 Da
    Quaternary structure:
    • Component of the heterotrimeric retromer cargo-selective complex (CSC), also descibed as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:11102511). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (Probable). Interacts with VPS29, VPS35, SNX1, SNX2, SNX5, SNX6, SNX3, SNX27, RAB7A, ECM29, EHD1, KIAA0196, SORL1 (PubMed:11102511, PubMed:16190980, PubMed:19619496, PubMed:17868075 PubMed:19531583, PubMed:20682791, PubMed:20923837PubMed:21725319, PubMed:22279231, PubMed:24344282, PubMed:16732284).

    Three dimensional structures from OCA and Proteopedia for VPS26A Gene

    Alternative splice isoforms for VPS26A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS26A Gene

Proteomics data for VPS26A Gene at MOPED

Post-translational modifications for VPS26A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys242

Other Protein References for VPS26A Gene

No data available for DME Specific Peptides for VPS26A Gene

Domains for VPS26A Gene

Protein Domains for VPS26A Gene

UniProtKB/Swiss-Prot:

VP26A_HUMAN
Family:
  • Belongs to the VPS26 family.:
    • O75436
genes like me logo Genes that share domains with VPS26A: view

No data available for Gene Families for VPS26A Gene

Function for VPS26A Gene

Molecular function for VPS26A Gene

UniProtKB/Swiss-Prot Function: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of FAM21A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated in Alzheimer disease. No polymorphism or variant is however associated with Alzheimer disease for VPS26A.

Gene Ontology (GO) - Molecular Function for VPS26A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11102511
GO:0008565 protein transporter activity NAS 11102511
genes like me logo Genes that share ontologies with VPS26A: view
genes like me logo Genes that share phenotypes with VPS26A: view

Animal Models for VPS26A Gene

MGI Knock Outs for VPS26A:

miRNA for VPS26A Gene

miRTarBase miRNAs that target VPS26A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VPS26A Gene

Localization for VPS26A Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS26A Gene

Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome. Note=Localizes to tubular profiles adjacent to endosomes (PubMed:15078903). Predominantly found in early not late endosomes (By similarity). {ECO:0000250 UniProtKB:P40336}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS26A Gene COMPARTMENTS Subcellular localization image for VPS26A gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 2

Gene Ontology (GO) - Cellular Components for VPS26A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 20682791
GO:0005769 early endosome IDA 15078903
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with VPS26A: view

Pathways for VPS26A Gene

genes like me logo Genes that share pathways with VPS26A: view

Pathways by source for VPS26A Gene

Gene Ontology (GO) - Biological Process for VPS26A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0015031 protein transport --
GO:0042147 retrograde transport, endosome to Golgi NAS 11102511
GO:1990126 retrograde transport, endosome to plasma membrane IMP 21602791
genes like me logo Genes that share ontologies with VPS26A: view

Transcripts for VPS26A Gene

Unigene Clusters for VPS26A Gene

Vacuolar protein sorting 26 homolog A (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS26A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for VPS26A Gene

GeneLoc Exon Structure for
VPS26A
ECgene alternative splicing isoforms for
VPS26A

Expression for VPS26A Gene

mRNA expression in normal human tissues for VPS26A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS26A Gene

SOURCE GeneReport for Unigene cluster for VPS26A Gene Hs.499925

genes like me logo Genes that share expressions with VPS26A: view

Orthologs for VPS26A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS26A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS26A 36
  • 99.9 (n)
  • 100 (a)
VPS26A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS26A 36
  • 95.92 (n)
  • 99.69 (a)
VPS26A 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS26A 36
  • 95.91 (n)
  • 99.39 (a)
VPS26A 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps26a 36
  • 91.1 (n)
  • 99.08 (a)
Vps26a 16
Vps26a 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS26A 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS26A 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps26a 36
  • 90.72 (n)
  • 98.78 (a)
chicken
(Gallus gallus)
Aves VPS26A 36
  • 86.61 (n)
  • 96.63 (a)
VPS26A 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS26A 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5005 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6997 36
vps26a 36
  • 79.86 (n)
  • 93.25 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.253 36
zebrafish
(Danio rerio)
Actinopterygii vps26a 36
  • 77.03 (n)
  • 90.77 (a)
vps26a 37
  • 89 (a)
OneToOne
zgc56673 36
fruit fly
(Drosophila melanogaster)
Insecta Vps26 37
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-26 37
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP8 37
  • 33 (a)
OneToMany
PEP8 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4964 36
soybean
(Glycine max)
eudicotyledons Gma.9189 36
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS26B 36
  • 58.87 (n)
  • 59.66 (a)
corn
(Zea mays)
Liliopsida Zm.5111 36
rice
(Oryza sativa)
Liliopsida Os.21158 36
Os11g0629200 36
  • 58.76 (n)
  • 57.97 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1398 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2536 37
  • 59 (a)
OneToMany
Species with no ortholog for VPS26A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for VPS26A Gene

ENSEMBL:
Gene Tree for VPS26A (if available)
TreeFam:
Gene Tree for VPS26A (if available)

Paralogs for VPS26A Gene

Paralogs for VPS26A Gene

Selected SIMAP similar genes for VPS26A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for VPS26A Gene

genes like me logo Genes that share paralogs with VPS26A: view

Variants for VPS26A Gene

Sequence variations from dbSNP and Humsavar for VPS26A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs14578 -- 69,172,753(+) GTCAT(C/T)TGCAT utr-variant-3-prime
rs951717 -- 69,168,640(-) AAGTG(C/G)CACCA intron-variant
rs951718 -- 69,168,288(-) ctttg(C/T)aggat intron-variant
rs1048717 -- 69,172,085(+) GAAAC(A/G)TATTT utr-variant-3-prime
rs1472820 -- 69,172,896(-) GAGAA(C/T)AGAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VPS26A Gene

Variant ID Type Subtype PubMed ID
nsv7010 CNV Loss 18451855
nsv895694 CNV Gain 21882294
nsv508589 CNV Loss 20534489
nsv819970 CNV Loss 19587683

Relevant External Links for VPS26A Gene

HapMap Linkage Disequilibrium report
VPS26A

Disorders for VPS26A Gene

Relevant External Links for VPS26A

Genetic Association Database (GAD)
VPS26A
Human Genome Epidemiology (HuGE) Navigator
VPS26A
genes like me logo Genes that share disorders with VPS26A: view

No data available for UniProtKB/Swiss-Prot for VPS26A Gene

Publications for VPS26A Gene

  1. No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. (PMID: 16784798) Riemenschneider M. … Forstl H. (Neurobiol. Aging 2007) 3 4 23 49
  2. Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. (PMID: 19531583) Seaman M.N. … Bright N. (J. Cell. Sci. 2009) 3 4 23
  3. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. (PMID: 16732284) Shi H. … Hurley J.H. (Nat. Struct. Mol. Biol. 2006) 3 4 23
  4. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  5. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. (PMID: 11102511) Renfrew Haft C. … Taylor S.I. (Mol. Biol. Cell 2000) 3 4

Products for VPS26A Gene

Sources for VPS26A Gene

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