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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS26A Gene

protein-coding   GIFtS: 55
GCID: GC10P070885

vacuolar protein sorting 26 homolog A (S. pombe)

(Previous names: vacuolar protein sorting 26 (yeast homolog), vacuolar protein...)
(Previous symbol: VPS26)
 Explore 2 diseases affiliated with
VPS26A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VPS26A    

Aliases
for VPS26A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vacuolar Protein Sorting 26 Homolog A (S. Pombe)1 2     Vacuolar Protein Sorting 26 (Yeast Homolog)1
VPS261 2 3 5     Vacuolar Protein Sorting 26 (Yeast)1
Hbeta581 2     Vacuolar Protein Sorting 26 Homolog A (Yeast)1
PEP8A1 2     Vacuolar Protein Sorting-Associated Protein 26A2
Vesicle Protein Sorting 26A2 3     HVPS261
HB582 5     

External Ids:    HGNC: 127111   Entrez Gene: 95592   Ensembl: ENSG000001229587   OMIM: 6055065   UniProtKB: O754363   

Export aliases for VPS26A gene to outside databases

Previous GC identifers: GC10P070556 GC10P064883


Summaries
for VPS26A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VPS26A:
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large
multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the
trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex
suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein
interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VP26A_HUMAN, O75436
Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R
and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric
immunoglobulin receptor (pIgR-pIgA)

Gene Wiki entry for VPS26A


Genomic Views
for VPS26A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS26A gene promoter:
         USF1   AML1a   FOXO3   FOXO3b   N-Myc   Egr-2   POU2F1   POU2F1a   USF-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VPS26A promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS26A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS26A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21.1

VPS26A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS26A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070885:  view genomic region     (about GC identifiers)

Start:
 70,883,268 bp from pter      End:
 70,932,617 bp from pter
Size:
 49,350 bases      Orientation:
 plus strand

Proteins
for VPS26A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VP26A_HUMAN, O75436 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 26A  
Size: 327 amino acids; 38170 Da
Subunit: Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts
directly with VPS35. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ECM29
Subcellular location: Cytoplasm. Endosome membrane; Peripheral membrane protein
1 PDB 3D structure from and Proteopedia for VPS26A:
2FAU (3D)    
Secondary accessions: A8MZ56 B2RDD3 Q8TBH4 Q9H982
Alternative splicing: 2 isoforms:  O75436-1   O75436-2   (No experimental confirmation available. Ref.6 (BQ048905) sequence is in conflict in position: 243:G->R)

Explore the universe of human proteins at neXtProt for VPS26A: NX_O75436

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75436

    • VPS26A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001030337.1  NP_004887.2  

    ENSEMBL proteins: 
     ENSP00000362480   ENSP00000263559   ENSP00000378532   ENSP00000446081   ENSP00000442705  

    Human Recombinant Protein Products: 
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    Novus Biologicals VPS26A Proteins
    Novus Biologicals VPS26A Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for VPS26A
    Uscn Proteins for VPS26A

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA--
    GO:0005829cytosol IDA11102511
    GO:0010008endosome membrane IEA--
    GO:0030904retromer complex IEA--
    GO:0031982vesicle IDA--


    VPS26A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for VPS26A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VPS26A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005377 VPS26

    Graphical View of Domain Structure for InterPro Entry O75436

    ProtoNet protein and cluster: O75436

    1 Blocks protein family: IPB005377 Vacuolar protein sorting-associated protein 26

    UniProtKB/Swiss-Prot: VP26A_HUMAN, O75436
    Similarity: Belongs to the VPS26 family


    Function
    for VPS26A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VP26A_HUMAN, O75436
    Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R
    and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric
    immunoglobulin receptor (pIgR-pIgA)
    Induction: Down-regulated in Alzheimer disease. No polymorphism or variant is however associated with Alzheimer disease
    for VPS26A

    miRNA
    Products:            		miRTarBase miRNAs that target VPS26A:
    hsa-mir-373 (MIRT004448)

    OriGene 3'-UTR Clone (see all 2): VPS26A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS26A
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS26A (see all 25):
    hsa-miR-485-5p hsa-miR-548j hsa-miR-607 hsa-miR-3200-5p hsa-miR-548i hsa-miR-374a* hsa-miR-1304 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: VPS26A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS26A (see all 7)
    OriGene shRNA RFP: VPS26A
    OriGene siRNA: VPS26A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS26A

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS26A (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 2): VPS26A (NM_001035260)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for VPS26A

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS26A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11102511
    GO:0008565protein transporter activity NAS11102511


    VPS26A for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Vps26atm1Cos for VPS26A
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vps26a):
     cardiovascular system  craniofacial  embryogenesis  growth/size  mortality/aging 
     nervous system  normal 

    VPS26A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VPS26A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS26A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/19 Interacting proteins for VPS26A (O754363 ENSP000002635594) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ILKQ134183, ENSP000002994214I2D: score=1 STRING: ENSP00000299421
    SMYD2Q9NRG43, ENSP000003559244I2D: score=1 STRING: ENSP00000355924
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007034vacuolar transport IEA--
    GO:0015031protein transport ----
    GO:0042147retrograde transport, endosome to Golgi NAS11102511


    VPS26A for ontologies           About GeneDecksing



    Drugs & Compounds
    for VPS26A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS26A
    Search CenterWatch for drugs/clinical trials and news about VPS26A / VP26A 

    Transcripts
    for VPS26A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VPS26A gene (2 alternative transcripts): 
    NM_001035260.1  NM_004896.3  

    Unigene Cluster for VPS26A:

    Vacuolar protein sorting 26 homolog A (S. pombe)
    Hs.499925  [show with all ESTs]
    Unigene Representative Sequence: BX647725
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373382(uc001jpb.3 uc001jpc.3 uc009xqa.3 uc001jpd.3)
    ENST00000477667 ENST00000489656 ENST00000497564 ENST00000490696 ENST00000467852
    ENST00000489794 ENST00000497022 ENST00000263559 ENST00000395098 ENST00000546041
    ENST00000541711

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS26A
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS26A (see all 25):
    hsa-miR-485-5p hsa-miR-548j hsa-miR-607 hsa-miR-3200-5p hsa-miR-548i hsa-miR-374a* hsa-miR-1304 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: VPS26A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS26A (see all 7)
    OriGene shRNA RFP: VPS26A
    OriGene siRNA: VPS26A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS26A
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): VPS26A (NM_001035260)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS26A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS26A 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS26A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS26A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS26A

    Additional cDNA sequence: 

    AF054179.1 AF175266.1 AK022992.1 AK290536.1 AK297142.1 AK309021.1 AK315496.1 AL110166.1 
    BC022505.1 BC131761.1 BX647725.1 BX649092.1 

    21 DOTS entries:

    DT.455635  DT.100813062  DT.100813060  DT.92471418  DT.97864257  DT.92471474  DT.101983549  DT.121249244 
    DT.121249220  DT.95234375  DT.100041970  DT.121249237  DT.92471446  DT.95234376  DT.100041971  DT.100651254 
    DT.100801167  DT.100801491  DT.102825661  DT.121249253  DT.207859 

    24/332 AceView cDNA sequences (see all 332):

    AA993788 CF552797 CK904667 AA305020 BM693819 BM464330 BM843312 CR618440 
    AI214338 BI764336 BM479615 CB322032 BU509268 BQ216565 BU633615 AI687383 
    AI591156 AI031912 AA885350 AA307017 BX097619 AA683242 AI380376 BM740310 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VPS26A (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                -                                               -         
    SP2:                                -     -                                         -         
    SP3:        -     -     -           -                                                         
    SP4:                                -     -     -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for VPS26A

    Expression
    for VPS26A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS26A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTATAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See VPS26A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS26A

    SOURCE GeneReport for Unigene cluster: Hs.499925
        SABiosciences Custom PCR Arrays for VPS26A
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS26A

    Orthologs
    for VPS26A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS26A gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Vps26a1 , 5 vacuolar protein sorting 26 homolog A (yeast)1, 5 91.13(n)1
    99.08(a)1    		   10 (32.41 cM)5
    309301  NM_133672.31  NP_598433.11 
     624548435 
    chicken
    (Gallus gallus)    		 Aves VPS26A1 vacuolar protein sorting 26 homolog A (S. pombe) 86.61(n)
    96.63(a)    		   423696  XM_421577.3  XP_421577.2 
    lizard
    (Anolis carolinensis)    		 Reptilia VPS26A6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343215.1(1993863-2005644)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.50052 Xenopus laevis transcribed sequence with strong similarity more 80.76(n)    BX854783.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc566732 similar to vacuolar protein sorting 26 (yeast) 78.48(n)   393881  AY391469.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea vps-266
    		 Vacuolar protein sorting-associated protein 26
    		 48(a)
    		 1 → many
    		 IV(9339383-9341773)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons VPS26B1 vacuolar protein sorting-associated protein 26 58.87(n)
    59.66(a)    		   828883  NM_118908.4  NP_194499.2 
    rice
    (Oryza sativa)    		 Liliopsida Os.211582 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.33(n)    AK065196.1 


    ENSEMBL Gene Tree for VPS26A (if available)
    TreeFam Gene Tree for VPS26A (if available) 

    Paralogs
    for VPS26A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPS26A gene
    VPS26B2  
    1 SIMAP similar gene for VPS26A using alignment to 3 protein entries:     VP26A_HUMAN (see all proteins):
    VPS26B

    VPS26A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VPS26A
    PGOHUM00000238136


    Genomic Variants
    for VPS26A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/929 NCBI SNPs in VPS26A are shown (see all 929)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1837958861,2
    		--70881965(+) CTAGTA/GTGACT 2 -- us2k10--------
    rs348773341,2
    		--70882048(+) CTTTGC/G/TTATGT 2 -- us2k10--------
    rs340958721,2
    		C,F,--70882252(+) GGAGTG/CTCGCT 2 -- us2k13Minor allele frequency- C:0.33NA 6
    rs122639591,2
    		--70882299(+) ctcacA/Tgcaat 2 -- us2k1 tfbs30--------
    rs47468171,2
    		C,F,H,--70882515(+) CACCAC/TGCCTG 2 -- us2k122Minor allele frequency- T:0.21NS EA NA WA CSA 2332
    rs1932811601,2
    		--70882574(+) CACTGC/GATTCC 2 -- us2k10--------
    rs1854398061,2
    		--70882648(+) TTTTTG/TAGACA 2 -- us2k10--------
    rs115958791,2
    		C,F,H,--70882713(+) AACCTC/TCGCTT 2 -- us2k15Minor allele frequency- T:0.08NA EA 250
    rs732725871,2
    		C,F,--70882729(+) ATTCAA/GGAGAT 2 -- us2k13Minor allele frequency- G:0.18WA CSA 122
    rs1128365891,2
    		C,--70882747(+) TCTGAC/ACTCAG 2 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for VPS26A (70883268 - 70932617 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for VPS26A
         1 CNV: 58463

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    Disorders / Diseases
    for VPS26A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VPS26A for disorders           About GeneDecksing

    OMIM gene information: 605506    OMIM disorders: --

    2 diseases for VPS26A:    About MalaCards
    alzheimer's disease    malaria

    Human Genome Epidemiology (HuGE) Navigator: VPS26A (2 documents)

    Export disorders for VPS26A gene to outside databases

    Publications
    for VPS26A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS26A gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with VPS26A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (1998)
    2. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. (PubMed id 16732284)1, 2, 9 Shi H.... Hurley J.H. (2006)
    3. No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. (PubMed id 16784798)1, 2, 9 Riemenschneider M.... Forstl H. (2007)
    4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (2010)
    5. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. (PubMed id 16407403)1, 2 Gullapalli A.... Trejo J. (2006)
    6. Model-guided microarray implicates the retromer complex in Alzheimer's disease. (PubMed id 16315276)1, 2 Small S.A.... Kim T.-W. (2005)
    7. A novel mammalian retromer component, Vps26B. (PubMed id 16190980)1, 2 Kerr M.C.... Teasdale R.D. (2005)
    8. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. (PubMed id 15247922)1, 2 Verges M.... Mostov K.E. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Exportin 7 defines a novel general nuclear export pathway. (PubMed id 15282546)1, 2 Mingot J.-M.... Goerlich D. (2004)

    External Searches for VPS26A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing VPS26A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9559 HGNC: 12711 AceView: VPS26 Ensembl:ENSG00000122958 euGenes: HUgn9559
    ECgene: VPS26A H-InvDB: VPS26A

    Other Databases showing VPS26A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VPS26A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS26A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VPS26A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VPS26A gene:
    Search GeneIP for patents involving VPS26A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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