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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS25 Gene

protein-coding   GIFtS: 56
GCID: GC17P040925

vacuolar protein sorting 25 homolog (S. cerevisiae)

(Previous name: vacuolar protein sorting 25 (yeast) )
 Explore 2 diseases affiliated with
VPS25 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VPS25    

Aliases
for VPS25 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vacuolar Protein Sorting 25 Homolog (S. Cerevisiae)1 2     FAP202 5
DERP91 2 3     MGC105401
EAP201 2 3     Vacuolar Protein Sorting 25 (Yeast)1
Dermal Papilla-Derived Protein 92 3     Vacuolar Protein-Sorting-Associated Protein 252
ELL-Associated Protein Of 20 KDa2 3     HVps251
ESCRT-II Complex Subunit VPS252 3     

External Ids:    HGNC: 281221   Entrez Gene: 843132   Ensembl: ENSG000001314757   OMIM: 6109075   UniProtKB: Q9BRG13   

Export aliases for VPS25 gene to outside databases

Previous GC identifers: GC17P038179 GC17P036689


Summaries
for VPS25 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VPS25:
VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a
complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a
multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 (PubMed
15755741); Kamura et al., 2001 (PubMed 11278625)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required
for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates
delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably
involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription
regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of
certain RNA viruses

Gene Wiki entry for VPS25


Genomic Views
for VPS25 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS25 gene promoter:
         MZF-1   GATA-3   SREBP-1a   SREBP-1c   CUTL1   Roaz   SREBP-1b   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VPS25 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

VPS25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS25 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040925:  view genomic region     (about GC identifiers)

Start:
 40,925,454 bp from pter      End:
 40,931,617 bp from pter
Size:
 6,164 bases      Orientation:
 plus strand

Proteins
for VPS25 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1 (See protein sequence)
Recommended Name: Vacuolar protein-sorting-associated protein 25  
Size: 176 amino acids; 20748 Da
Subunit: Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity).
Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and 2 copies
of VPS25. Interacts with CFTR; the interaction requires misfolded CFTR. Interacts (via C-terminal half) with the
ESCRT-III subunit CHMP6 (via N-terminal half)
Subcellular location: Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the
cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6
3 PDB 3D structures from and Proteopedia for VPS25:
2ZME (3D)        3CUQ (3D)        3HTU (3D)    
Secondary accessions: B2R581

Explore the universe of human proteins at neXtProt for VPS25: NX_Q9BRG1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BRG1

    • VPS25 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_115729.1  
    ENSEMBL proteins: 
     ENSP00000253794   ENSP00000467225   ENSP00000466909   ENSP00000465798  
    Reactome Protein details: Q9BRG1
    Human Recombinant Protein Products: 
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    Novus Biologicals VPS25 Proteins
    Novus Biologicals VPS25 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for VPS25
    Uscn Proteins for VPS25

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IEA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane IEA--


    VPS25 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for VPS25

    Protein Domains /
    Families
    for VPS25 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VPS25 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR014041 ESCRT-II_cplx_Vps25-sub_N
     IPR008570 ESCRT-II_cplx_vps25-sub

    Graphical View of Domain Structure for InterPro Entry Q9BRG1

    ProtoNet protein and cluster: Q9BRG1

    UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1
    Similarity: Belongs to the VPS25 family


    Function
    for VPS25 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1
    Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required
    for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates
    delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably
    involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription
    regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of
    certain RNA viruses

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS25
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS25 (see all 16):
    hsa-miR-1226 hsa-miR-29a hsa-miR-29c hsa-miR-3653 hsa-miR-1184 hsa-miR-889 hsa-miR-3116 hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmid: VPS25 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS25 (see all 4)
    OriGene shRNA RFP: VPS25
    OriGene siRNA: VPS25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS25

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS25 (see all 2)
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    In Situ Assay
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    Pathways & Interactions
    for VPS25 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Membrane Trafficking
    		Membrane Trafficking1.00
    2Endocytosis
    		Endocytosis1.00
    3Normal wtCFTR traffic / Sorting endosome formation
    		Delta508-CFTR traffic / Sorting endosome formation in CF0.77
    4Clathrin-dependent protein traffic
    		wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    5Signal Transduction
    		Endosomal Sorting Complex Required For Transport (ESCRT)0.14

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for VPS25
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF

    2        Reactome Pathways for VPS25
        Membrane Trafficking
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1         Kegg Pathway  (Kegg details for VPS25):
        Endocytosis


    VPS25 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for VPS25 (Q9BRG12, 3 ENSP000002537944) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APIPQ96GX92, 3, ENSP000002783594MINT-67303 I2D: score=5 STRING: ENSP00000278359
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66224 I2D: score=5 STRING: ENSP00000360441
    SNF8Q96H202, 3, ENSP000002903304MINT-67113 I2D: score=9 STRING: ENSP00000290330
    VPS36Q86VN13, ENSP000003672994I2D: score=5 STRING: ENSP00000367299
    CHMP6Q96FZ73, ENSP000003174684I2D: score=5 STRING: ENSP00000317468
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0015031protein transport IEA--
    GO:0016044cellular membrane organization TAS--
    GO:0016197endosomal transport TAS--


    VPS25 for ontologies           About GeneDecksing



    Drugs & Compounds
    for VPS25 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS25
    Search CenterWatch for drugs/clinical trials and news about VPS25 

    Transcripts
    for VPS25 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VPS25 gene: 
    NM_032353.2  

    Unigene Cluster for VPS25:

    Vacuolar protein sorting 25 homolog (S. cerevisiae)
    Hs.500165  [show with all ESTs]
    Unigene Representative Sequence: BM918546
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253794(uc002ibi.3) ENST00000591584 ENST00000589219 ENST00000589577
    ENST00000590339 ENST00000589520

    miRNA
    Products:             		 OriGene 3'-UTR Clone: VPS25
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VPS25
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS25 (see all 16):
    hsa-miR-1226 hsa-miR-29a hsa-miR-29c hsa-miR-3653 hsa-miR-1184 hsa-miR-889 hsa-miR-3116 hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmid: VPS25 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VPS25 (see all 4)
    OriGene shRNA RFP: VPS25
    OriGene siRNA: VPS25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VPS25
    Clone
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    GenScript: all cDNA clones in your preferred vector: VPS25 (NM_032353)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS25
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS25

    Additional cDNA sequence: 

    AB014763.1 AK312092.1 BC006282.2 

    10 DOTS entries:

    DT.447643  DT.218176  DT.100798122  DT.100798125  DT.97827431  DT.100798121  DT.101958040  DT.120912369 
    DT.92439703  DT.95072733 

    24/351 AceView cDNA sequences (see all 351):

    CR620674 BM673381 CA422394 BM682027 CR615047 BQ053239 BM770763 BE386260 
    BQ673775 BQ009543 BM666754 AB014763 Z43084 BE393518 BM554015 CB854316 
    BU540421 AI925697 CA487570 BE855382 NM_032353 BM810698 AI718182 CA455057 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VPS25 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                          -           -                 -                     
    SP2:                          -           -                 -                     
    SP3:                          -           -                                       
    SP4:                          -           -                 -                     
    SP5:                          -                                                   


    ECgene alternative splicing isoforms for VPS25

    Expression
    for VPS25 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTCTGTCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    VPS25 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VPS25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS25

    SOURCE GeneReport for Unigene cluster: Hs.500165

    UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1
    Tissue specificity: Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression
    are found in heart, skeletal muscle, brain and lung

        SABiosciences Custom PCR Arrays for VPS25
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS25

    Orthologs
    for VPS25 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS25 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Vps251 , 5 vacuolar protein sorting 25 (yeast)1, 5 92.61(n)1
    98.86(a)1    		   11 (64.48 cM)5
    280841  NM_026776.31  NP_081052.21 
     1012537075 
    chicken
    (Gallus gallus)    		 Aves VPS251 vacuolar protein sorting 25 homolog (S. cerevisiae) 74.14(n)
    77.59(a)    		   420021  XM_003642814.1  XP_003642862.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.73092 Xenopus laevis transcribed sequence with moderate similarity more 76.02(n)    BJ627490.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii vps251 vacuolar protein sorting 25 (yeast) 72.99(n)
    78.16(a)    		   407684  NM_001089362.2  NP_001082831.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Vps251 Vacuolar protein sorting 25 53.61(n)
    43.27(a)    		   35847  NM_136554.3  NP_610398.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea vps-251 Protein VPS-25 48.85(n)
    43.1(a)    		   173143  NM_060829.5  NP_493230.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons VPS251 vacuolar protein sorting-associated protein 25 47.93(n)
    37.28(a)    		   827637  NM_202841.2  NP_974570.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g06585001 hypothetical protein 46.21(n)
    40.91(a)    		   4327163  NM_001050299.1  NP_001043764.1 


    ENSEMBL Gene Tree for VPS25 (if available)
    TreeFam Gene Tree for VPS25 (if available) 

    Paralogs
    for VPS25 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPS25 gene

    VPS25 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VPS25
    PGOHUM00000244868


    Genomic Variants
    for VPS25 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 NCBI SNPs in VPS25 are shown (see all 93)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1501412161,2
    		--40923473(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1386149771,2
    		--40923503(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs1492949271,2
    		--40923510(+) GCCACC/TAAGCC 1 -- us2k10--------
    rs1874095761,2
    		--40923596(+) AAGGGC/TGAGAG 1 -- us2k10--------
    rs1159157611,2
    		F,--40923624(+) TCCTGG/TAGGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1922492181,2
    		--40923686(+) AGTCCA/GAAAGG 1 -- us2k10--------
    rs1129620191,2
    		--40923738(+) GAGGCA/CGAGGT 1 -- us2k12Minor allele frequency- C:0.00CSA 2
    rs1128722571,2
    		--40923903(+) GGGAGA/GCAGAG 1 -- us2k12Minor allele frequency- G:0.00CSA 2
    rs733211191,2
    		C,--40923946(+) CCAACC/TCGGCA 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs748959431,2
    		C--40923985(+) AAAAAA/GAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for VPS25 (40925454 - 40931617 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for VPS25: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for VPS25 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VPS25 for disorders           About GeneDecksing

    OMIM gene information: 610907    OMIM disorders: --

    2 diseases for VPS25:    About MalaCards
    sarcoma    immunodeficiency

    Human Genome Epidemiology (HuGE) Navigator: VPS25 (3 documents)

    Export disorders for VPS25 gene to outside databases

    Publications
    for VPS25 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS25 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with VPS25)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. (PubMed id 15511219)1, 2, 3 Yorikawa C....Maki M. (2005)
    2. Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. (PubMed id 19686684)1, 2 Im Y.J.... Hurley J.H. (2009)
    3. Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. (PubMed id 18539118)1, 2 Im Y.J. and Hurley J.H. (2008)
    4. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. (PubMed id 16973552)1, 2 Langelier C.... Sundquist W.I. (2006)
    5. Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. (PubMed id 15007060)1, 2 Sharma M.... Lukacs G.L. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)
    8. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. (PubMed id 14519844)1, 2 Martin-Serrano J.... Bieniasz P.D. (2003)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for VPS25 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VPS25 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84313 HGNC: 28122 AceView: MGC10540 Ensembl:ENSG00000131475 euGenes: HUgn84313
    ECgene: VPS25 Kegg: 84313 H-InvDB: VPS25

    Other Databases showing VPS25 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VPS25 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS25 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VPS25 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VPS25 gene:
    Search GeneIP for patents involving VPS25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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