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VPS25 Gene

protein-coding   GIFtS: 60
GCID: GC17P040925

Vacuolar Protein Sorting 25 Homolog (S. Cerevisiae)

(Previous name: vacuolar protein sorting 25 (yeast))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 25 Homolog (S. Cerevisiae)1 2     ESCRT-II Complex Subunit VPS252 3
Dermal Papilla-Derived Protein 92 3     FAP202 5
DERP92 3     Vacuolar Protein Sorting 25 (Yeast)1
EAP202 3     Vacuolar Protein-Sorting-Associated Protein 252
ELL-Associated Protein Of 20 KDa2 3     hVps253

External Ids:    HGNC: 281221   Entrez Gene: 843132   Ensembl: ENSG000001314757   OMIM: 6109075   UniProtKB: Q9BRG13   

Export aliases for VPS25 gene to outside databases

Previous GC identifers: GC17P038179 GC17P036689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS25 Gene:
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II
(ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A
pseudogene of this gene is present on chromosome 1. (provided by RefSeq, Jul 2013)

GeneCards Summary for VPS25 Gene:
VPS25 (vacuolar protein sorting 25 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS25 include hiv-1, and malaria.

UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is
required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB
pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II
complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a
role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in
facilitating the budding of certain RNA viruses

Gene Wiki entry for VPS25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS25 gene promoter:
         MZF-1   GATA-3   SREBP-1a   SREBP-1c   CUTL1   Roaz   SREBP-1b   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS25 promoter sequence
   Search Chromatin IP Primers for VPS25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

VPS25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS25 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040925:  view genomic region     (about GC identifiers)

Start:
40,925,454 bp from pter      End:
40,931,617 bp from pter
Size:
6,164 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1 (See protein sequence)
Recommended Name: Vacuolar protein-sorting-associated protein 25  
Size: 176 amino acids; 20748 Da
Subunit: Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity).
Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and 2
copies of VPS25. Interacts with CFTR; the interaction requires misfolded CFTR. Interacts (via C-terminal half)
with the ESCRT-III subunit CHMP6 (via N-terminal half)
3 PDB 3D structures from and Proteopedia for VPS25:
2ZME (3D)        3CUQ (3D)        3HTU (3D)    
Secondary accessions: B2R581

Explore the universe of human proteins at neXtProt for VPS25: NX_Q9BRG1

Explore proteomics data for VPS25 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys64
  • Modification sites at PhosphoSitePlus

  • See VPS25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115729.1  
    ENSEMBL proteins: 
     ENSP00000253794   ENSP00000467225   ENSP00000466909   ENSP00000465798  
    Reactome Protein details: Q9BRG1

    VPS25 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014041 ESCRT-II_cplx_Vps25-sub_N
     IPR011991 WHTH_DNA-bd_dom
     IPR008570 ESCRT-II_cplx_vps25-sub

    Graphical View of Domain Structure for InterPro Entry Q9BRG1

    ProtoNet protein and cluster: Q9BRG1

    UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1
    Similarity: Belongs to the VPS25 family


    VPS25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS25_HUMAN, Q9BRG1
    Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is
    required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB
    pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II
    complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a
    role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in
    facilitating the budding of certain RNA viruses

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS25
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    miRNA
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    miRTarBase miRNAs that target VPS25:
    hsa-mir-24-3p (MIRT030413)

    Block miRNA regulation of human, mouse, rat VPS25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS25 (see all 16):
    hsa-miR-1226 hsa-miR-29a hsa-miR-29c hsa-miR-3653 hsa-miR-1184 hsa-miR-889 hsa-miR-3116 hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidVPS25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS25

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS25_HUMAN, Q9BRG1: Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout
    the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus5
    cytosol4
    mitochondrion2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    VPS25 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VPS25 About    
    See pathways by source

    SuperPathContained pathways About
    1Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    2Clathrin dependent protein traffic
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Delta508 CFTR traffic Sorting endosome formation in CF
    Delta508 CFTR traffic Sorting endosome formation in CF

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for VPS25
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF


    1 Reactome Pathway for VPS25
        Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for VPS25):
        Endocytosis


    VPS25 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS25
    Interactions:

        GeneGlobe Interaction Network for VPS25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS25 (Q9BRG12, 3 ENSP000002537944) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APIPQ96GX92, 3, ENSP000002783594MINT-67303 I2D: score=5 STRING: ENSP00000278359
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66224 I2D: score=5 STRING: ENSP00000360441
    SNF8Q96H202, 3, ENSP000002903304MINT-67113 I2D: score=9 STRING: ENSP00000290330
    VPS36Q86VN13, ENSP000003672994I2D: score=5 STRING: ENSP00000367299
    CHMP6Q96FZ73, ENSP000003174684I2D: score=5 STRING: ENSP00000317468
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0015031protein transport IEA--
    GO:0016197endosomal transport TAS--
    GO:0061024membrane organization TAS--

    VPS25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS25



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VPS25 gene: 
    NM_032353.3  

    Unigene Cluster for VPS25:

    Vacuolar protein sorting 25 homolog (S. cerevisiae)
    Hs.500165  [show with all ESTs]
    Unigene Representative Sequence: BM918546
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253794(uc002ibi.3) ENST00000591584 ENST00000589219 ENST00000589577
    ENST00000590339 ENST00000589520
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate VPS25 (see all 16):
    hsa-miR-1226 hsa-miR-29a hsa-miR-29c hsa-miR-3653 hsa-miR-1184 hsa-miR-889 hsa-miR-3116 hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidVPS25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS25
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS25
      QuantiTect SYBR Green Assays in human, mouse, rat VPS25
      QuantiFast Probe-based Assays in human, mouse, rat VPS25

    Additional mRNA sequence: 

    AB014763.1 AK312092.1 BC006282.2 

    10 DOTS entries:

    DT.447643  DT.218176  DT.100798122  DT.100798125  DT.97827431  DT.100798121  DT.101958040  DT.120912369 
    DT.92439703  DT.95072733 

    Selected AceView cDNA sequences (see all 351):

    BE264160 AI015669 BQ084195 CA422394 Z43084 BE251213 BU168204 BQ672154 
    CA487864 CR620674 BM707546 BU627617 BM770763 BM682027 BM673381 BU629313 
    CB305855 BM666754 AB014763 CA487561 BQ673129 AI524459 BP375743 BI823119 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS25 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                          -           -                 -                     
    SP2:                          -           -                 -                     
    SP3:                          -           -                                       
    SP4:                          -           -                 -                     
    SP5:                          -                                                   


    ECgene alternative splicing isoforms for VPS25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTGTCTC
    VPS25 Expression
    About this image

    VPS25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500165

    UniProtKB/Swiss-Prot: VPS25_HUMAN, Q9BRG1
    Tissue specificity: Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of
    expression are found in heart, skeletal muscle, brain and lung

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    QuantiFast Probe-based Assays in human, mouse, rat VPS25
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS25 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps251 , 5 vacuolar protein sorting 25 (yeast)1, 5 92.61(n)1
    98.86(a)1
      11 (64.48 cM)5
    280841  NM_001284411.11  NP_001271340.11 
     1012537075 
    chicken
    (Gallus gallus)
    Aves VPS251 vacuolar protein sorting 25 homolog (S. cerevisiae) 74.14(n)
    77.59(a)
      420021  XM_003642814.2  XP_003642862.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS256
    vacuolar protein sorting 25 homolog (S. cerevisiae...
    83(a)
    1 ↔ 1
    6(62129905-62141068)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73092 Xenopus laevis transcribed sequence with moderate similarity more 76.02(n)    BJ627490.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vps251 vacuolar protein sorting 25 (yeast) 72.99(n)
    78.16(a)
      407684  NM_001089362.2  NP_001082831.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps251 Vacuolar protein sorting 25 53.61(n)
    43.27(a)
      35847  NM_136554.3  NP_610398.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-251 vps-25 48.85(n)
    43.1(a)
      173143  NM_060829.6  NP_493230.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS25(YJR102C)4 Component of the ESCRT-II complex, which is involved more   --   10(619765-619157) 853566  NP_012636.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS251 VPS25 47.84(n)
    37.06(a)
      827637  NM_202841.2  NP_974570.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g06585001 Os01g0658500 45.56(n)
    40(a)
      4327163  NM_001050299.1  NP_001043764.1 


    ENSEMBL Gene Tree for VPS25 (if available)
    TreeFam Gene Tree for VPS25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS25 gene

    VPS25 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VPS25
    PGOHUM00000244868


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS25 (see all 124)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501412161,2
    --40923473(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1386149771,2
    --40923503(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs1492949271,2
    --40923510(+) GCCACC/TAAGCC 1 -- us2k10--------
    rs1874095761,2
    --40923596(+) AAGGGC/TGAGAG 1 -- us2k10--------
    rs1159157611,2
    C,F--40923624(+) TCCTGG/TAGGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1922492181,2
    --40923686(+) AGTCCA/GAAAGG 1 -- us2k10--------
    rs1129620191,2
    C--40923738(+) GAGGCA/CGAGGT 1 -- us2k12Minor allele frequency- C:0.00CSA 2
    rs1128722571,2
    C--40923903(+) GGGAGA/GCAGAG 1 -- us2k12Minor allele frequency- G:0.00CSA 2
    rs733211191,2
    C,F--40923946(+) CCAACC/TCGGCA 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs748959431,2
    C--40923985(+) AAAAAA/GAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for VPS25 (40925454 - 40931617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VPS25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833450CNV Loss17160897
    nsv827998CNV Loss20364138
    nsv908257CNV Loss21882294
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610907    OMIM disorders: --

    3 diseases for VPS25:    
    About MalaCards
    hiv-1    malaria    sarcoma


    VPS25 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VPS25
    Human Genome Epidemiology (HuGE) Navigator: VPS25 (3 documents)

    Export disorders for VPS25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS25 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with VPS25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. (PubMed id 15511219)1, 2, 3 Yorikawa C.... Maki M. (Biochem. J. 2005)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. (PubMed id 19686684)1, 2 Im Y.J.... Hurley J.H. (Dev. Cell 2009)
    4. Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. (PubMed id 18539118)1, 2 Im Y.J. and Hurley J.H. (Dev. Cell 2008)
    5. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. (PubMed id 16973552)1, 2 Langelier C.... Sundquist W.I. (J. Virol. 2006)
    6. Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. (PubMed id 15007060)1, 2 Sharma M.... Lukacs G.L. (J. Cell Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (Cell 2003)
    9. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. (PubMed id 14519844)1, 2 Martin-Serrano J.... Bieniasz P.D. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84313 HGNC: 28122 AceView: MGC10540 Ensembl:ENSG00000131475 euGenes: HUgn84313
    ECgene: VPS25 Kegg: 84313 H-InvDB: VPS25

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VPS25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for VPS25 gene:
    Search GeneIP for patents involving VPS25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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