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Aliases for VPS18 Gene

Aliases for VPS18 Gene

  • Vacuolar Protein Sorting 18 Homolog (S. Cerevisiae) 2 3
  • Vacuolar Protein Sorting Protein 18 2 3
  • HVPS18 3 4
  • Vacuolar Protein Sorting-Associated Protein 18 Homolog 3
  • KIAA1475 4
  • PEP3 3

External Ids for VPS18 Gene

Previous GeneCards Identifiers for VPS18 Gene

  • GC15P036554
  • GC15P034082
  • GC15P038765
  • GC15P038902
  • GC15P038974
  • GC15P041186
  • GC15P018034

Summaries for VPS18 Gene

Entrez Gene Summary for VPS18 Gene

  • Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for VPS18 Gene

VPS18 (Vacuolar Protein Sorting 18 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for VPS18 Gene

  • May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.

Gene Wiki entry for VPS18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS18 Gene

Genomics for VPS18 Gene

Regulatory Elements for VPS18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VPS18 Gene

Start:
40,894,430 bp from pter
End:
40,903,975 bp from pter
Size:
9,546 bases
Orientation:
Plus strand

Genomic View for VPS18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS18 Gene

Proteins for VPS18 Gene

  • Protein details for VPS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P253-VPS18_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 18 homolog
    Protein Accession:
    Q9P253
    Secondary Accessions:
    • Q8TCG0
    • Q96DI3
    • Q9H268

    Protein attributes for VPS18 Gene

    Size:
    973 amino acids
    Molecular mass:
    110186 Da
    Quaternary structure:
    • Interacts with HOOK1 (By similarity). Part of a large heterooligomeric complex together with VPS11, VPS16 and VPS33A. Interacts with STX7.
    SequenceCaution:
    • Sequence=AAH01513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAA95999.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for VPS18 Gene

Proteomics data for VPS18 Gene at MOPED

Post-translational modifications for VPS18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPS18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPS18 Gene

Domains for VPS18 Gene

Protein Domains for VPS18 Gene

Suggested Antigen Peptide Sequences for VPS18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P253

UniProtKB/Swiss-Prot:

VPS18_HUMAN :
  • Q9P253
Family:
  • Belongs to the VPS18 family.
Similarity:
  • Contains 1 CHCR (clathrin heavy-chain) repeat.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with VPS18: view

No data available for Gene Families for VPS18 Gene

Function for VPS18 Gene

Molecular function for VPS18 Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.

Gene Ontology (GO) - Molecular Function for VPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 20434987
GO:0019905 syntaxin binding IDA 11382755
GO:0030674 protein binding, bridging IBA --
genes like me logo Genes that share ontologies with VPS18: view
genes like me logo Genes that share phenotypes with VPS18: view

Animal Model Products

CRISPR Products

miRNA for VPS18 Gene

miRTarBase miRNAs that target VPS18

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS18 Gene

Localization for VPS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS18 Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS18 Gene COMPARTMENTS Subcellular localization image for VPS18 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
cytoskeleton 2
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 11382755
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome IBA --
GO:0005769 early endosome IEA --
GO:0005770 late endosome IDA 11382755
genes like me logo Genes that share ontologies with VPS18: view

Pathways for VPS18 Gene

SuperPathways for VPS18 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0007032 endosome organization IDA 18799622
GO:0007040 lysosome organization IDA 18799622
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with VPS18: view

No data available for Pathways by source for VPS18 Gene

Transcripts for VPS18 Gene

mRNA/cDNA for VPS18 Gene

Unigene Clusters for VPS18 Gene

Vacuolar protein sorting 18 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPS18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPS18 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2:
SP3: - -

Relevant External Links for VPS18 Gene

GeneLoc Exon Structure for
VPS18
ECgene alternative splicing isoforms for
VPS18

Expression for VPS18 Gene

mRNA expression in normal human tissues for VPS18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS18 Gene

SOURCE GeneReport for Unigene cluster for VPS18 Gene Hs.23876

mRNA Expression by UniProt/SwissProt for VPS18 Gene

Q9P253-VPS18_HUMAN
Tissue specificity: Ubiquitous. Expression was highest in heart and low in lung.
genes like me logo Genes that share expressions with VPS18: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VPS18 Gene

Orthologs for VPS18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS18 35
  • 99.59 (n)
  • 99.69 (a)
VPS18 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS18 35
  • 90.78 (n)
  • 97.12 (a)
VPS18 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS18 35
  • 91.26 (n)
  • 97.53 (a)
VPS18 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps18 35
  • 87.84 (n)
  • 95.79 (a)
Vps18 16
Vps18 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS18 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS18 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps18 35
  • 87.6 (n)
  • 95.17 (a)
chicken
(Gallus gallus)
Aves VPS18 35
  • 69.37 (n)
  • 74.1 (a)
VPS18 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS18 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps18 35
  • 65.63 (n)
  • 68.87 (a)
zebrafish
(Danio rerio)
Actinopterygii vps18 35
  • 65.5 (n)
  • 65.98 (a)
vps18 35
vps18 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000983 35
  • 50.6 (n)
  • 37.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta dor 35
  • 47.96 (n)
  • 36.19 (a)
dor 36
  • 35 (a)
OneToOne
dor 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea vps-18 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP3 36
  • 22 (a)
OneToOne
PEP3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12470 35
  • 46.51 (n)
  • 37.14 (a)
rice
(Oryza sativa)
Liliopsida Os08g0178100 35
  • 46.33 (n)
  • 37.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06183 35
  • 48.08 (n)
  • 36.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pep3 35
  • 39.46 (n)
  • 28.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1226 36
  • 43 (a)
OneToOne
Species with no ortholog for VPS18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS18 Gene

ENSEMBL:
Gene Tree for VPS18 (if available)
TreeFam:
Gene Tree for VPS18 (if available)

Paralogs for VPS18 Gene

Selected SIMAP similar genes for VPS18 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VPS18: view

No data available for Paralogs for VPS18 Gene

Variants for VPS18 Gene

Sequence variations from dbSNP and Humsavar for VPS18 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs595559 -- 40,900,360(+) CTGAC(C/T)CTCTA synonymous-codon, reference
rs611694 -- 40,898,525(+) GGAAT(A/G)CAGTG intron-variant
rs615736 -- 40,899,448(+) GAGGC(C/T)GAGCG reference, synonymous-codon
rs622589 -- 40,901,738(+) ctgtc(C/T)ctact intron-variant
rs673284 -- 40,898,267(+) TTTTT(C/T)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS18 Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
nsv904102 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
nsv904104 CNV Loss 21882294
nsv819345 CNV Loss 19587683

Relevant External Links for VPS18 Gene

HapMap Linkage Disequilibrium report
VPS18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS18 Gene

Disorders for VPS18 Gene

(1) University of Copenhagen DISEASES for VPS18 Gene

genes like me logo Genes that share disorders with VPS18: view

No data available for UniProtKB/Swiss-Prot for VPS18 Gene

Publications for VPS18 Gene

  1. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PMID: 11250079) Huizing M. … Kraemer H. (Gene 2001) 2 3 4
  2. Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. (PMID: 16203730) Yogosawa S. … Akazawa C. (J. Biol. Chem. 2005) 2 3 23
  3. Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. (PMID: 16996030) Yogosawa S. … Akazawa C. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for VPS18 Gene

  • antibodies-online proteins for VPS18
  • antibodies-online antibodies for VPS18
  • antibodies-online kits for VPS18

Sources for VPS18 Gene

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