VPS18 Gene
protein-coding GIFtS: 53
GCID: GC15P041186
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vacuolar protein sorting 18 homolog (S. cerevisiae)(Previous name: vacuolar protein sorting protein 18 )
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Aliases
for VPS18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vacuolar Protein Sorting 18 Homolog (S. Cerevisiae)1 2 | | PEP31 2 | | Vacuolar Protein Sorting Protein 181 2 | | KIAA14751 3 | | HVPS181 | | Vacuolar Protein Sorting-Associated Protein 18 Homolog2 |
Export aliases for VPS18 gene to outside databasesPrevious GC identifers: GC15P036554 GC15P034082 GC15P038765 GC15P038902 GC15P038974 GC15P018034 |
Summaries
for VPS18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VPS18:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinctorganelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved invesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian classC Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, maymediate vesicle trafficking steps in the endosome/lysosome pathway. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membranedocking/fusion reactions of late endosomes/lysosomes
Gene Wiki entry for VPS18
|
Genomic Views
for VPS18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VPS18 gene promoter:
SRF GR NF-1 SRF (504 AA) NF-E2 p45 PPAR-gamma1 c-Myb GR-alpha ZID NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for VPS18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q14-q15 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q14-q15VPS18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P041186: view genomic region
(about GC identifiers)
Start:
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41,186,628 bp from pter |
End:
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41,196,173 bp from pter |
Size:
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9,546 bases |
Orientation:
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plus strand |
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Proteins
for VPS18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253 (See
protein sequence)Recommended Name: Vacuolar protein sorting-associated protein 18 homolog Size: 973 amino acids; 110186 Da
Subunit: Interacts with HOOK1 (By similarity). Part of a large heterooligomeric complex together with VPS11, VPS16 andVPS33A. Interacts with STX7
Subcellular location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane;Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with lateendosomes/lysosomes
Sequence caution: Sequence=AAH01513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;Sequence=BAA95999.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8TCG0 Q96DI3 Q9H268Explore the universe of human proteins at neXtProt for VPS18: NX_Q9P253
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P253
VPS18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065908.1
ENSEMBL proteins: ENSP00000220509 ENSP00000453265 ENSP00000453555
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
VPS18 for ontologies About GeneDecksing
VPS18 Antibody Products:
Assay Products for VPS18: |
Protein
Domains /
Families
for VPS18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VPS18 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P253ProtoNet protein and cluster: Q9P253 2 Blocks protein families: IPB001841 Zn-finger IPB007810 Pep3/Vps18/deep orange
UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253Similarity: Belongs to the VPS18 familySimilarity: Contains 1 clathrin repeatSimilarity: Contains 1 RING-type zinc finger |
Function
for VPS18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membranedocking/fusion reactions of late endosomes/lysosomes
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS18
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS18 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
VPS18 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for VPS18:
Animal Models:
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Vps18):
VPS18 for phenotypes About GeneDecksing
|
Pathways & Interactions
for VPS18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/97 Interacting proteins for VPS18 (Q9P2531, 3 ENSP000002205094) via UniProtKB, MINT, STRING, and/or I2D (see all 97)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
VPS18 for ontologies About GeneDecksing
|
Drugs & Compounds
for VPS18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VPS18
Search CenterWatch for drugs/clinical trials and news about VPS18
|
Transcripts
for VPS18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VPS18 gene: NM_020857.2 Unigene Cluster for VPS18: Vacuolar protein sorting 18 homolog (S. cerevisiae) Hs.23876 [show with all ESTs]Unigene Representative Sequence: AL7137253 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000220509(uc001zne.3) ENST00000558855 ENST00000558474
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VPS18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VPS18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VPS18 (NM_020857) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VPS18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS18 |
Additional cDNA sequence: AB040908.1 AF308802.1 AL713725.1 BC001513.2 5 DOTS entries: DT.412982 DT.97845994 DT.70104280 DT.75103176 DT.95082977 24/164 AceView cDNA sequences (see all 164): CD244515 AW188900 BQ018419 AI928969 BX493534 BM556906 BQ065866 BU190317 AI560899 BQ061160 BU849674 AF308802 AL713725 CB853629 BQ057408 BM147591 BU159902 BU731471 BQ062095 BQ058903 AI587540 AW250200 BM987207 CB853069
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for VPS18 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
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| SP1: | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | |
ECgene alternative splicing isoforms for VPS18
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Expression
for VPS18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VPS18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTGTGCA
About this image
See VPS18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VPS18
SOURCE GeneReport for Unigene cluster: Hs.23876
UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253Tissue specificity: Ubiquitous. Expression was highest in heart and low in lung
SABiosciences Expression via Pathway-Focused PCR Array including VPS18:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VPS18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VPS18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS18 |
Orthologs
for VPS18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for VPS18 gene from 8/29 species (see all 29) About this table
ENSEMBL Gene Tree for VPS18 (if available)
TreeFam Gene Tree for VPS18 (if available) |
Paralogs
for VPS18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for VPS18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VPS18 (41186628 - 41196173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for VPS18
1 CNV: 58719 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VPS18 |
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Disorders
/ Diseases
for VPS18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VPS18 for disorders About GeneDecksing
OMIM gene information: 608551
OMIM disorders: --
2  diseases for VPS18: About MalaCardsconjunctivitis malaria
1 disease from the University of Copenhagen DISEASES database for VPS18:ARC syndrome Export disorders for VPS18 gene to outside databases
|
Publications
for VPS18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VPS18 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with VPS18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PubMed id 11250079)1, 2, 3 Huizing M.... Kraemer H. (2001)
- Ubiquitylation and degradation of serum-inducible kin ase by hVPS18, a RING-H2 type ubiquitin ligase. (PubMed id 16203730)1, 3, 9 Yogosawa S....Akazawa C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular characterization of mammalian homologues of class c Vps proteins that interact with syntaxin-7. (PubMed id 11382755)1, 2 Kim B.Y....Akazawa C. (2001)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. (PubMed id 16996030)1, 9 Yogosawa S....Akazawa C. (2006)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- HIV Assembly and Budding: Ca(2+) Signaling and Non-ESC RT Proteins Set the Stage. (PubMed id 22761998)1 Ehrlich L.S. and Carter C.A. (2012)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for VPS18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VPS18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VPS18 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing VPS18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VPS18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VPS18 gene:
Search GeneIP for patents involving VPS18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VPS18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | VPS18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS18 |
|  |  |  | | | | Search ThermoFisher Antibodies for VPS18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS18 |
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