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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPS18 Gene

protein-coding   GIFtS: 54
GCID: GC15P041186

Vacuolar Protein Sorting 18 Homolog (S. Cerevisiae)

(Previous name: vacuolar protein sorting protein 18)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vacuolar Protein Sorting 18 Homolog (S. Cerevisiae)1 2
Vacuolar Protein Sorting Protein 181 2
hVPS182 3
PEP32
Vacuolar Protein Sorting-Associated Protein 18 Homolog2
KIAA14753

External Ids:    HGNC: 159721   Entrez Gene: 576172   Ensembl: ENSG000001041427   OMIM: 6085515   UniProtKB: Q9P2533   

Export aliases for VPS18 gene to outside databases

Previous GC identifers: GC15P036554 GC15P034082 GC15P038765 GC15P038902 GC15P038974 GC15P018034


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPS18 Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The
mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast
counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. (provided by RefSeq, Jul
2008)

GeneCards Summary for VPS18 Gene: 
VPS18 (vacuolar protein sorting 18 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS18 include arc syndrome, and conjunctivitis. GO annotations related to this gene include actin binding and metal ion binding.

UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253
Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
docking/fusion reactions of late endosomes/lysosomes

Gene Wiki entry for VPS18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS18 gene promoter:
         SRF   GR   NF-1   SRF (504 AA)   NF-E2 p45   PPAR-gamma1   c-Myb   GR-alpha   ZID   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS18 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPS18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPS18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14-q15   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14-q15

VPS18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS18 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P041186:  view genomic region     (about GC identifiers)

Start:
41,186,628 bp from pter      End:
41,196,173 bp from pter
Size:
9,546 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 18 homolog  
Size: 973 amino acids; 110186 Da
Subunit: Interacts with HOOK1 (By similarity). Part of a large heterooligomeric complex together with VPS11, VPS16
and VPS33A. Interacts with STX7
Subcellular location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane;
Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late
endosomes/lysosomes
Sequence caution: Sequence=AAH01513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites; Sequence=BAA95999.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8TCG0 Q96DI3 Q9H268

Explore the universe of human proteins at neXtProt for VPS18: NX_Q9P253

Explore proteomics data for VPS18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P253

  • VPS18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VPS18 Protein Expression
    REFSEQ proteins: NP_065908.1  
    ENSEMBL proteins: 
     ENSP00000220509   ENSP00000453265   ENSP00000453555  

    Human Recombinant Protein Products for VPS18: 
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    Cloud-Clone Corp. Proteins for VPS18 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005769early endosome IEA--
    GO:0005884actin filament IEA--
    GO:0030897HOPS complex IDA19109425
    GO:0031902late endosome membrane IEA--

    VPS18 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007810 Pep3_Vps18
     IPR000547 Clathrin_H-chain/VPS_repeat

    Graphical View of Domain Structure for InterPro Entry Q9P253

    ProtoNet protein and cluster: Q9P253

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB007810 Pep3/Vps18/deep orange


    UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253
    Similarity: Belongs to the VPS18 family
    Similarity: Contains 1 CHCR (clathrin heavy-chain) repeat
    Similarity: Contains 1 RING-type zinc finger


    VPS18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS18_HUMAN, Q9P253
    Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
    docking/fusion reactions of late endosomes/lysosomes

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    VPS18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS18:
     Decreased TP53 protein express 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vps18):
     cellular  growth/size  mortality/aging  nervous system 

    VPS18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for VPS18 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS18 
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    SwitchGear 3'UTR luciferase reporter plasmidVPS18 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VPS18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for VPS18 (Q9P2531, 3 ENSP000002205094) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MON1BQ7L1V21, 3, ENSP000002482484EBI-1053363,EBI-2655311 I2D: score=1 STRING: ENSP00000248248
    VPS16Q9H2693, ENSP000003698104I2D: score=9 STRING: ENSP00000369810
    STX8Q9UNK03, ENSP000003052554I2D: score=2 STRING: ENSP00000305255
    AKTIPQ9H8T03, ENSP000003002454I2D: score=1 STRING: ENSP00000300245
    GGA1Q9UJY53, ENSP000003413444I2D: score=1 STRING: ENSP00000341344
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007032endosome organization IDA18799622
    GO:0007040lysosome organization IDA18799622
    GO:0016192vesicle-mediated transport IEA--

    VPS18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS18

    Search CenterWatch for drugs/clinical trials and news about VPS18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPS18 gene: 
    NM_020857.2  

    Unigene Cluster for VPS18:

    Vacuolar protein sorting 18 homolog (S. cerevisiae)
    Hs.23876  [show with all ESTs]
    Unigene Representative Sequence: AL713725
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220509(uc001zne.3) ENST00000558855 ENST00000558474

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate VPS18:
    hsa-miR-146a* hsa-miR-4314 hsa-miR-155 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidVPS18 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPS18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPS18

    Additional mRNA sequence: 

    AB040908.1 AF308802.1 AL713725.1 BC001513.2 

    5 DOTS entries:

    DT.412982  DT.97845994  DT.70104280  DT.75103176  DT.95082977 

    24/164 AceView cDNA sequences (see all 164):

    BQ062095 AI560899 BM147591 BQ058274 BM556906 AA476967 BE792062 BU190317 
    CK905184 CD635831 AI863323 AW250200 BU159902 BU849674 BX493534 AI928969 
    BQ061160 AL524858 CB852559 BX117101 BQ018419 AA879408 CB853069 AB040908 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VPS18    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                    -                           
    SP2:                                                
    SP3:                    -           -               


    ECgene alternative splicing isoforms for VPS18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPS18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGTGCA
    VPS18 Expression
    About this image


    See VPS18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPS18

    SOURCE GeneReport for Unigene cluster: Hs.23876

    UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253
    Tissue specificity: Ubiquitous. Expression was highest in heart and low in lung

        SABiosciences Expression via Pathway-Focused PCR Array including VPS18: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS18 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps181 , 5 vacuolar protein sorting 18 (yeast)1, 5 87.84(n)1
    95.79(a)1
      2 (59.97 cM)5
    2285451  NM_172269.31  NP_758473.31 
     1192887405 
    chicken
    (Gallus gallus)
    Aves VPS181 vacuolar protein sorting 18 homolog (S. cerevisiae) 69.37(n)
    74.1(a)
      423207  NM_001199655.1  NP_001186584.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS186
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343264.1(274159-285483)
    zebrafish
    (Danio rerio)
    Actinopterygii vps182 vacuolar protein sorting protein 18 72.13(n)   192319  AF506204.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dor1 , 3 ommochrome biosynthesis3
    deep orange1
    29(a)3
    48.41(n)1
    36.74(a)1
      1 2B53
    311181  NM_057938.41  NP_477286.21 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-186
    Protein VPS-18
    26(a)
    1 ↔ 1
    II(4461131-4467895)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP3(YLR148W)4 Component of CORVET tethering complex; vacuolar peripheral more   --   12(434641-437397) 850840  NP_013249.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G124701 zinc ion binding protein 46.63(n)
    37.14(a)
      837804  NM_101119.6  NP_172709.2 
    rice
    (Oryza sativa)
    Liliopsida Os08g01781001 hypothetical protein 46.25(n)
    37.07(a)
      4344807  NM_001067661.1  NP_001061126.1 


    ENSEMBL Gene Tree for VPS18 (if available)
    TreeFam Gene Tree for VPS18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPS18 gene
    1 SIMAP similar gene for VPS18 using alignment to 3 protein entries:     VPS18_HUMAN (see all proteins):
    ADAM10

    VPS18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/341 SNPs in VPS18 are shown (see all 341)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359504
    A colorectal cancer sample4--see VAR_0359502 A S mis40--------
    rs740119001,2
    C--41184779(+) TCATTG/TCAACT 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs1850763511,2
    --41184835(+) AAGAAC/TTGAAG 1 -- us2k10--------
    rs1385094421,2
    --41185003(+) ACTCTA/GTGTCC 1 -- us2k10--------
    rs773254171,2
    C,F--41185131(+) ATGTAT/CGGAGC 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1145423011,2
    F--41185252(+) TGAGGC/TTGCAG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs740119011,2
    C--41185293(+) GAAGGG/CAAATG 1 -- us2k13Minor allele frequency- C:0.14WA EA 240
    rs1120554231,2
    F--41185376(+) AGTGGG/TGCTGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs760269011,2
    C,F--41185531(+) GTGGCG/AACCCT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs766480891,2
    C,F--41185677(+) GAGGAC/TTCCCC 1 -- us2k11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for VPS18 (41186628 - 41196173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for VPS18:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2360n71CNV Loss21882294
    nsv904102CNV Loss21882294
    nsv819345CNV Loss19587683
    nsv904104CNV Loss21882294
    nsv904101CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608551    OMIM disorders: --

    2 diseases for VPS18:    About MalaCards
    arc syndrome    conjunctivitis

    1 disease from the University of Copenhagen DISEASES database for VPS18:
    ARC syndrome

    VPS18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Export disorders for VPS18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPS18 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with VPS18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PubMed id 11250079)1, 2, 3 Huizing M.... Kraemer H. (2001)
    2. Ubiquitylation and degradation of serum-inducible kin ase by hVPS18, a RING-H2 type ubiquitin ligase. (PubMed id 16203730)1, 3, 9 Yogosawa S....Akazawa C. (2005)
    3. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Molecular characterization of mammalian homologues of class c Vps proteins that interact with syntaxin-7. (PubMed id 11382755)1, 2 Kim B.Y....Akazawa C. (2001)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    7. Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. (PubMed id 16996030)1, 9 Yogosawa S....Akazawa C. (2006)
    8. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. (PubMed id 23434281)1 Ulbricht A....Hohfeld J. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57617 HGNC: 15972 AceView: VPS18 Ensembl:ENSG00000104142 euGenes: HUgn57617
    ECgene: VPS18 H-InvDB: VPS18

    (According to HUGE)
    About This Section
    HUGE: KIAA1475

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPS18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPS18 gene:
    Search GeneIP for patents involving VPS18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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