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VPS18 Gene

protein-coding   GIFtS: 54
GCID: GC15P041186

Vacuolar Protein Sorting 18 Homolog (S. Cerevisiae)

(Previous name: vacuolar protein sorting protein 18)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 18 Homolog (S. Cerevisiae)1 2
Vacuolar Protein Sorting Protein 181 2
hVPS182 3
PEP32
Vacuolar Protein Sorting-Associated Protein 18 Homolog2
KIAA14753

External Ids:    HGNC: 159721   Entrez Gene: 576172   Ensembl: ENSG000001041427   OMIM: 6085515   UniProtKB: Q9P2533   

Export aliases for VPS18 gene to outside databases

Previous GC identifers: GC15P036554 GC15P034082 GC15P038765 GC15P038902 GC15P038974 GC15P018034


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS18 Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The
mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast
counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. (provided by RefSeq, Jul
2008)

GeneCards Summary for VPS18 Gene:
VPS18 (vacuolar protein sorting 18 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS18 include arc syndrome, and conjunctivitis. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253
Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
docking/fusion reactions of late endosomes/lysosomes

Gene Wiki entry for VPS18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS18 gene promoter:
         SRF   GR   NF-1   SRF (504 AA)   NF-E2 p45   PPAR-gamma1   c-Myb   GR-alpha   ZID   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS18 promoter sequence
   Search Chromatin IP Primers for VPS18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14-q15   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14-q15

VPS18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS18 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P041186:  view genomic region     (about GC identifiers)

Start:
41,186,628 bp from pter      End:
41,196,173 bp from pter
Size:
9,546 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 18 homolog  
Size: 973 amino acids; 110186 Da
Subunit: Interacts with HOOK1 (By similarity). Part of a large heterooligomeric complex together with VPS11, VPS16
and VPS33A. Interacts with STX7
Sequence caution: Sequence=AAH01513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites; Sequence=BAA95999.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8TCG0 Q96DI3 Q9H268

Explore the universe of human proteins at neXtProt for VPS18: NX_Q9P253

Explore proteomics data for VPS18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VPS18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065908.1  
    ENSEMBL proteins: 
     ENSP00000220509   ENSP00000453265   ENSP00000453555  

    VPS18 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for VPS18

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    Cloud-Clone Corp. CLIAs for VPS18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000547 Clathrin_H-chain/VPS_repeat
     IPR007810 Pep3_Vps18

    Graphical View of Domain Structure for InterPro Entry Q9P253

    ProtoNet protein and cluster: Q9P253

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB007810 Pep3/Vps18/deep orange


    UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253
    Similarity: Belongs to the VPS18 family
    Similarity: Contains 1 CHCR (clathrin heavy-chain) repeat
    Similarity: Contains 1 RING-type zinc finger


    VPS18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS18_HUMAN, Q9P253
    Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
    docking/fusion reactions of late endosomes/lysosomes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    VPS18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS18:
     Decreased TP53 protein express 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vps18):
     cellular  growth/size/body  mortality/aging  nervous system 

    VPS18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS18
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS18

    miRNA
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    miRTarBase miRNAs that target VPS18:
    hsa-mir-155-5p (MIRT021057), hsa-mir-324-3p (MIRT042991), hsa-mir-615-3p (MIRT039983)

    Block miRNA regulation of human, mouse, rat VPS18 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate VPS18:
    hsa-miR-146a* hsa-miR-4314 hsa-miR-155 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidVPS18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS18

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    GenScript: all cDNA clones in your preferred vector: VPS18 (NM_020857)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VPS18

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS18_HUMAN, Q9P253: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane;
    Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic, peripheral membrane protein associated with late
    endosomes/lysosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    cytoskeleton2
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005769early endosome IEA--
    GO:0005884actin filament IEA--
    GO:0030897HOPS complex IDA19109425
    GO:0031902late endosome membrane IEA--

    VPS18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including VPS18: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for VPS18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS18 (Q9P2531, 3 ENSP000002205094) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MON1BQ7L1V21, 3, ENSP000002482484EBI-1053363,EBI-2655311 I2D: score=1 STRING: ENSP00000248248
    VPS16Q9H2693, ENSP000003698104I2D: score=9 STRING: ENSP00000369810
    ARFGEF1Q9Y6D63, ENSP000002622154I2D: score=4 STRING: ENSP00000262215
    STX6O437523, ENSP000002583014I2D: score=2 STRING: ENSP00000258301
    STX8Q9UNK03, ENSP000003052554I2D: score=2 STRING: ENSP00000305255
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007032endosome organization IDA18799622
    GO:0007040lysosome organization IDA18799622
    GO:0016192vesicle-mediated transport IEA--

    VPS18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS18



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VPS18 gene: 
    NM_020857.2  

    Unigene Cluster for VPS18:

    Vacuolar protein sorting 18 homolog (S. cerevisiae)
    Hs.23876  [show with all ESTs]
    Unigene Representative Sequence: AL713725
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220509(uc001zne.3) ENST00000558855 ENST00000558474
    miRNA
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    Block miRNA regulation of human, mouse, rat VPS18 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate VPS18:
    hsa-miR-146a* hsa-miR-4314 hsa-miR-155 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidVPS18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS18
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    OriGene qPCR primer pairs and template standards for VPS18
    OriGene qSTAR qPCR primer pairs in human, mouse for VPS18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS18
      QuantiTect SYBR Green Assays in human, mouse, rat VPS18
      QuantiFast Probe-based Assays in human, mouse, rat VPS18

    Additional mRNA sequence: 

    AB040908.1 AF308802.1 AL713725.1 BC001513.2 

    5 DOTS entries:

    DT.412982  DT.97845994  DT.70104280  DT.75103176  DT.95082977 

    Selected AceView cDNA sequences (see all 164):

    AI200098 AF308802 AB040908 BQ058274 BQ062095 CA413853 BM987207 BE792062 
    CB853629 AI587540 AL713725 AW250200 BM314059 CA487573 BM699277 CD244515 
    AL524858 BQ065866 BM972971 BX117101 BM669495 AI915111 BM556906 CD635831 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VPS18    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                    -                           
    SP2:                                                
    SP3:                    -           -               


    ECgene alternative splicing isoforms for VPS18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGTGCA
    VPS18 Expression
    About this image

    VPS18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23876

    UniProtKB/Swiss-Prot: VPS18_HUMAN, Q9P253
    Tissue specificity: Ubiquitous. Expression was highest in heart and low in lung

        Pathway & Disease-focused RT2 Profiler PCR Array including VPS18: 
              Ubiquitin Ligases in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS18 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps181 , 5 vacuolar protein sorting 18 (yeast)1, 5 87.84(n)1
    95.79(a)1
      2 (59.97 cM)5
    2285451  NM_172269.31  NP_758473.31 
     1192887405 
    chicken
    (Gallus gallus)
    Aves VPS181 vacuolar protein sorting 18 homolog (S. cerevisiae) 69.37(n)
    74.1(a)
      423207  NM_001199655.1  NP_001186584.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPS186
    vacuolar protein sorting 18 homolog (S. cerevisiae...
    72(a)
    1 ↔ 1
    GL343264.1(274159-285483)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vps181 vacuolar protein sorting 18 homolog 65.63(n)
    68.87(a)
      100158548  NM_001127982.1  NP_001121454.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vps182 vacuolar protein sorting protein 18 72.13(n)   192319  AF506204.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dor1 , 3 ommochrome biosynthesis3
    deep orange1
    29(a)3
    47.96(n)1
    36.19(a)1
      1 2B53
    311181  NM_057938.41  NP_477286.21 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-186
    Protein VPS-18 (vps-18) mRNA, complete cds
    26(a)
    1 ↔ 1
    II(4461131-4467895) WBGene00021058
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP3(YLR148W)4 Component of CORVET tethering complex; vacuolar peripheral more   --   12(434641-437397) 850840  NP_013249.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G124701 AT1G12470 46.51(n)
    37.14(a)
      837804  NM_101119.6  NP_172709.2 
    rice
    (Oryza sativa)
    Liliopsida Os08g01781001 Os08g0178100 46.33(n)
    37.08(a)
      4344807  NM_001067661.1  NP_001061126.1 


    ENSEMBL Gene Tree for VPS18 (if available)
    TreeFam Gene Tree for VPS18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS18 gene
    1 SIMAP similar gene for VPS18 using alignment to 3 protein entries:     VPS18_HUMAN (see all proteins):
    ADAM10

    VPS18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS18 (see all 341)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359504
    A colorectal cancer sample4--see VAR_0359502 A S mis40--------
    rs740119001,2
    C--41184779(+) TCATTG/TCAACT 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs1850763511,2
    --41184835(+) AAGAAC/TTGAAG 1 -- us2k10--------
    rs1385094421,2
    --41185003(+) ACTCTA/GTGTCC 1 -- us2k10--------
    rs773254171,2
    C,F--41185131(+) ATGTAT/CGGAGC 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1145423011,2
    F--41185252(+) TGAGGC/TTGCAG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs740119011,2
    C--41185293(+) GAAGGG/CAAATG 1 -- us2k13Minor allele frequency- C:0.14WA EA 240
    rs1120554231,2
    F--41185376(+) AGTGGG/TGCTGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs760269011,2
    C,F--41185531(+) GTGGCG/AACCCT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs766480891,2
    C,F--41185677(+) GAGGAC/TTCCCC 1 -- us2k11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for VPS18 (41186628 - 41196173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for VPS18:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2360n71CNV Loss21882294
    nsv904102CNV Loss21882294
    nsv819345CNV Loss19587683
    nsv904104CNV Loss21882294
    nsv904101CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608551    OMIM disorders: --

    6 diseases for VPS18:    
    About MalaCards
    arc syndrome    conjunctivitis    breast and colorectal cancer    malaria
    hiv-1    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for VPS18:
    ARC syndrome

    VPS18 for disorders           About GeneDecksing


    Export disorders for VPS18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS18 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with VPS18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PubMed id 11250079)1, 2, 3 Huizing M.... Kraemer H. (Gene 2001)
    2. Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. (PubMed id 16203730)1, 3, 9 Yogosawa S....Akazawa C. (J. Biol. Chem. 2005)
    3. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (Traffic 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. (PubMed id 11382755)1, 2 Kim B.Y....Akazawa C. (J. Biol. Chem. 2001)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. (PubMed id 16996030)1, 9 Yogosawa S....Akazawa C. (Biochem. Biophys. Res. Commun. 2006)
    8. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. (PubMed id 23434281)1 Ulbricht A....HAPhfeld J. (Curr. Biol. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. HIV Assembly and Budding: Ca(2+) Signaling and Non-ESCRT Proteins Set the Stage. (PubMed id 22761998)1 Ehrlich L.S. and Carter C.A. (Mol Biol Int 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57617 HGNC: 15972 AceView: VPS18 Ensembl:ENSG00000104142 euGenes: HUgn57617
    ECgene: VPS18 H-InvDB: VPS18

    (According to HUGE)
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    HUGE: KIAA1475

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPS18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPS18 gene:
    Search GeneIP for patents involving VPS18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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