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VPS13C Gene

protein-coding   GIFtS: 52
GCID: GC15M062144

Vacuolar Protein Sorting 13 Homolog C (S. Cerevisiae)

(Previous name: vacuolar protein sorting 13C (yeast))
  See VPS13C-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 13 Homolog C (S. Cerevisiae)1 2
KIAA14213 5
Vacuolar Protein Sorting 13C (Yeast)1
Vacuolar Protein Sorting-Associated Protein 13C2

External Ids:    HGNC: 235941   Entrez Gene: 548322   Ensembl: ENSG000001290037   OMIM: 6088795   UniProtKB: Q709C83   

Export aliases for VPS13C gene to outside databases

Previous GC identifers: GC15M059860 GC15M059931 GC15M038966


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS13C Gene:
This gene encodes a member of the vacuolar protein sorting-associated 13 gene family. Alternate splicing results
in multiple transcript variants. (provided by RefSeq, Oct 2010)

GeneCards Summary for VPS13C Gene:
VPS13C (vacuolar protein sorting 13 homolog C (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS13C include chorea-acanthocytosis. An important paralog of this gene is VPS13B.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS13C gene promoter:
         USF1   AML1a   FOXO3   NF-E2 p45   POU3F2   Egr-2   USF-1   Pax-4a   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS13C promoter sequence
   Search Chromatin IP Primers for VPS13C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS13C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q21.3

VPS13C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS13C gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M062144:  view genomic region     (about GC identifiers)

Start:
62,144,588 bp from pter      End:
62,352,672 bp from pter
Size:
208,085 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VP13C_HUMAN, Q709C8 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 13C  
Size: 3753 amino acids; 422390 Da
Sequence caution: Sequence=BAA90972.1; Type=Erroneous initiation; Sequence=BAA92659.1; Type=Erroneous initiation;
Secondary accessions: Q6ISR4 Q702P2 Q702P3 Q709C9 Q9NXN8 Q9P2C6
Alternative splicing: 4 isoforms:  Q709C8-1   Q709C8-2   Q709C8-3   Q709C8-4   

Explore the universe of human proteins at neXtProt for VPS13C: NX_Q709C8

Explore proteomics data for VPS13C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys578, Lys2155, Lys2233, Lys2304, Lys2357, Lys2777, Lys3487, Lys3496, Lys3501, Lys3557
  • Modification sites at PhosphoSitePlus

  • See VPS13C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001018098.1  NP_060154.3  NP_060550.2  NP_065872.1  

    ENSEMBL proteins: 
     ENSP00000249837   ENSP00000261517   ENSP00000379233   ENSP00000379235  

    VPS13C Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for VPS13C

     
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    VPS13C Assay Products:

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    Search eBioscience for ELISAs for VPS13C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR015412 Autophagy-rel_C
     IPR009543 VPSAP_dom
     IPR026847 VPS13
     IPR026854 VPS13A_N

    Graphical View of Domain Structure for InterPro Entry Q709C8

    ProtoNet protein and cluster: Q709C8

    1 Blocks protein domain: IPB009543 Protein of unknown function DUF1162

    UniProtKB/Swiss-Prot: VP13C_HUMAN, Q709C8
    Similarity: Belongs to the VPS13 family


    Find genes that share domains with VPS13C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for VPS13C:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Vps13c (no phenotypes)

    Find genes that share phenotypes with VPS13C           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS13C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VPS13C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPS13C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPS13C

    miRNA
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    miRTarBase miRNAs that target VPS13C:
    hsa-mir-326 (MIRT043638), hsa-mir-192-5p (MIRT026941), hsa-mir-186-5p (MIRT045079), hsa-mir-378a-3p (MIRT043946), hsa-mir-26b-5p (MIRT030336), hsa-mir-215-5p (MIRT024877), hsa-mir-128-3p (MIRT022057)

    Block miRNA regulation of human, mouse, rat VPS13C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS13C (see all 51):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-607 hsa-miR-106a hsa-miR-938 hsa-miR-29a hsa-miR-30d hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidVPS13C 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS13C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with VPS13C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPS13C
    Interactions:

        Search GeneGlobe Interaction Network for VPS13C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VPS13C (Q709C83 ENSP000002615174) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB24Q969Q53I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    CETN3ENSP000002831224STRING: ENSP00000283122
    CHTF18ENSP000002623154STRING: ENSP00000262315
    PSMA2ENSP000002233214STRING: ENSP00000223321
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS13C (VP13C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS13C gene (4 alternative transcripts): 
    NM_001018088.2  NM_017684.4  NM_018080.3  NM_020821.2  

    Unigene Cluster for VPS13C:

    Vacuolar protein sorting 13 homolog C (S. cerevisiae)
    Hs.511668  [show with all ESTs]
    Unigene Representative Sequence: NM_001018088
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249837(uc002aha.3) ENST00000261517(uc002agz.3) ENST00000560637
    ENST00000559119 ENST00000395896(uc002ahb.2 uc002ahc.2) ENST00000395898
    ENST00000558919 ENST00000558338(uc002ahd.1) ENST00000558088 ENST00000561258

    miRNA
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    Block miRNA regulation of human, mouse, rat VPS13C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VPS13C (see all 51):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-607 hsa-miR-106a hsa-miR-938 hsa-miR-29a hsa-miR-30d hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidVPS13C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPS13C
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    GenScript: all cDNA clones in your preferred vector (see all 4): VPS13C (NM_018080)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VPS13C
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat VPS13C
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for VPS13C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VPS13C
      QuantiTect SYBR Green Assays in human, mouse, rat VPS13C
      QuantiFast Probe-based Assays in human, mouse, rat VPS13C

    Additional mRNA sequence: 

    AB037842.1 AJ608770.1 AJ608771.1 AJ626860.1 AJ626861.1 AK000143.1 AK001243.1 AK025014.1 
    AK025364.1 AK056744.1 AK123851.1 AK128650.1 AK304408.1 AK307518.1 AL833377.1 BC069387.1 
    BX648470.1 BX648766.1 CR936716.1 

    15 DOTS entries:

    DT.311680  DT.102828000  DT.87046481  DT.91814093  DT.91764214  DT.401945  DT.309340  DT.40239598 
    DT.452212  DT.100777440  DT.91721406  DT.121073045  DT.100777439  DT.75183345  DT.95147891 

    Selected AceView cDNA sequences (see all 225):

    AI393840 AI760563 AJ626861 AI690009 BF958689 AA663968 CA413453 BM930556 
    BE222324 BU685398 AI382154 AK128650 AI292080 AL833377 AW468066 AA682572 
    AI127855 BU679870 AW858807 AA292722 BP344355 AJ608771 AW591906 AL040500 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS13C (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                -     -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                                -     -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60a · 60b ^ 61 ^ 62 ^ 63 ^ 64 ^ 65 ^ 66a · 66b ^ 67 ^ 68 ^ 69 ^ 70 ^ 71 ^ 72 ^ 73 ^ 74 ^ 75 ^ 76 ^
    SP1:                                                                                            -                                                               
    SP2:                                                                                            -                                                               
    SP3:                                                                                            -                                                               
    SP4:                                                                                            -                                                               
    SP5:                                                                                                                                                            

    ExUns: 77 ^ 78 ^ 79 ^ 80 ^ 81 ^ 82 ^ 83a · 83b ^ 84 ^ 85 ^
    SP1:                                -     -                     
    SP2:                                -     -                     
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for VPS13C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS13C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTTAAGG
    VPS13C Expression
    About this image

    VPS13C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS13C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511668

    UniProtKB/Swiss-Prot: VP13C_HUMAN, Q709C8
    Tissue specificity: Widely expressed

        Custom PCR Arrays for VPS13C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS13C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for VPS13C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps13c1 , 5 vacuolar protein sorting 13C (yeast)1, 5 84.42(n)1
    86.61(a)1
      9 (36.77 cM)5
    3205281  NM_177184.31  NP_796158.21 
     678403965 
    chicken
    (Gallus gallus)
    Aves VPS13C1 vacuolar protein sorting 13 homolog C (S. cerevisiae) 71.5(n)
    69.24(a)
      415376  XM_001232999.3  XP_001233000.2 
    lizard
    (Anolis carolinensis)
    Reptilia VPS13C6
    vacuolar protein sorting 13 homolog C (S. cerevisi...
    68(a)
    1 ↔ 1
    GL343428.1(774975-838032)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vps13c1 vacuolar protein sorting 13 homolog C (S. cerevisiae) 65.85(n)
    64.52(a)
      100495847  XM_002934563.2  XP_002934609.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7987461 vacuolar protein sorting-associated protein 13C-like 62.01(n)
    60.8(a)
      798746  XM_001922732.3  XP_001922767.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps136
    Vacuolar protein sorting 13
    30(a)
    1 → many
    2R(3454336-3468180)
    worm
    (Caenorhabditis elegans)
    Secernentea T08G11.16
    Protein T08G11.1, isoform b (T08G11.1) mRNA, compl...
    29(a)
    1 → many
    I(8905639-8916805) WBGene00011629
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS136
    Protein of unknown function; heterooligomeric or h...
    21(a)
    1 → many
    XII(54211-63645) YLL040C


    ENSEMBL Gene Tree for VPS13C (if available)
    TreeFam Gene Tree for VPS13C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS13C gene
    VPS13B2  VPS13D2  VPS13A2  
    1 SIMAP similar gene for VPS13C using alignment to 1 protein entry:     VP13C_HUMAN:
    VPS13A

    Find genes that share paralogs with VPS13C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for VPS13C (see all 4866)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785873221,2
    C--38982981(+) AAAAA-/TWCATC 4 -- int10--------
    rs340319181,2
    C--39016859(+) TCTTC-/AAAAAA 4 -- int11Minor allele frequency- A:0.00NA 2
    rs356378541,2
    C--39018820(+) AAAAAA/-TGTGA 4 -- int11Minor allele frequency- -:0.00NA 2
    rs113778341,2
    C--39037742(+) AAAAA-/AGGAAG 4 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs624022381,2
    C--39120148(-) CAAGCA/CAATGG 4 -- int10--------
    rs58131281,2
    C,F--39151020(+) TAATTA/-AAGTC 4 -- int14Minor allele frequency- -:0.38NA CSA 8
    rs1500724331,2
    --42205985(+) CCAGAA/CTGCCA 2 -- ds50010--------
    rs1844923721,2
    --42205994(+) CATGCA/CGTCTA 2 -- ds50010--------
    rs1454067981,2
    --42206033(+) TCTTCA/CAGCCA 2 -- ds50010--------
    rs1413655601,2
    --42206041(+) CCAAAC/GTCGGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for VPS13C (62144588 - 62352672 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VPS13C (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749762CNV Deletion23290073
    esv2582405CNV Deletion19546169
    esv273087CNV Insertion20981092
    esv1275705CNV Insertion17803354
    esv270546CNV Insertion20981092
    nsv521334CNV Loss19592680
    dgv2395n71CNV Loss21882294
    dgv2394n71CNV Loss21882294
    nsv457178CNV Loss19166990
    nsv457177CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS13C
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS13C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608879    OMIM disorders: --

    1 disease for VPS13C:    
    About MalaCards
    chorea-acanthocytosis

    1 disease from the University of Copenhagen DISEASES database for VPS13C:
    chorea-acanthocytosis

    Find genes that share disorders with VPS13C           About GenesLikeMe

    Genetic Association Database (GAD): VPS13C
    Human Genome Epidemiology (HuGE) Navigator: VPS13C (4 documents)

    Export disorders for VPS13C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for VPS13C gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with VPS13C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PubMed id 20081857)1, 4 Saxena R....Watanabe R.M. (Nat. Genet. 2010)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    3. Analysis of the human VPS13 gene family. (PubMed id 15498460)1, 2 Velayos-Baeza A....Monaco A.P. (Genomics 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    8. Genetic variants in GCKR, GIPR, ADCY5 and VPS13C and the risk of severe sulfonylurea-induced hypoglycaemia in patients with type 2 diabetes. (PubMed id 22956255)1 Holstein J.D....Holstein A. (amp 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. (PubMed id 22581228)1 Manning A.K....Langenberg C. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 54832 HGNC: 23594 AceView: VPS13C Ensembl:ENSG00000129003 euGenes: HUgn54832
    ECgene: VPS13C H-InvDB: VPS13C

    (According to HUGE)
    About This Section

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    HUGE: KIAA1421

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VPS13C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VPS13C gene:
    Search GeneIP for patents involving VPS13C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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