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Aliases for VPS13C Gene

Aliases for VPS13C Gene

  • Vacuolar Protein Sorting 13 Homolog C (S. Cerevisiae) 2 3
  • KIAA1421 4 6
  • Vacuolar Protein Sorting 13C (Yeast) 2

External Ids for VPS13C Gene

Summaries for VPS13C Gene

Entrez Gene Summary for VPS13C Gene

  • This gene encodes a member of the vacuolar protein sorting-associated 13 gene family. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

GeneCards Summary for VPS13C Gene

VPS13C (Vacuolar Protein Sorting 13 Homolog C (S. Cerevisiae)) is a Protein Coding gene. An important paralog of this gene is VPS13B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS13C Gene

Genomics for VPS13C Gene

Genomic Location for VPS13C Gene

Start:
61,852,389 bp from pter
End:
62,060,473 bp from pter
Size:
208,085 bases
Orientation:
Minus strand

Genomic View for VPS13C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS13C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS13C Gene

Regulatory Elements for VPS13C Gene

Proteins for VPS13C Gene

  • Protein details for VPS13C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q709C8-VP13C_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 13C
    Protein Accession:
    Q709C8
    Secondary Accessions:
    • Q6ISR4
    • Q702P2
    • Q702P3
    • Q709C9
    • Q9NXN8
    • Q9P2C6

    Protein attributes for VPS13C Gene

    Size:
    3753 amino acids
    Molecular mass:
    422390 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92659.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VPS13C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VPS13C Gene

Proteomics data for VPS13C Gene at MOPED

Post-translational modifications for VPS13C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys578, Lys2155, Lys2233, Lys2304, Lys2357, Lys2777, Lys3487, Lys3496, Lys3501, and Lys3557

Other Protein References for VPS13C Gene

No data available for DME Specific Peptides for VPS13C Gene

Domains for VPS13C Gene

Protein Domains for VPS13C Gene

UniProtKB/Swiss-Prot:

VP13C_HUMAN
Family:
  • Belongs to the VPS13 family.:
    • Q709C8
genes like me logo Genes that share domains with VPS13C: view

No data available for Gene Families for VPS13C Gene

Function for VPS13C Gene

Phenotypes for VPS13C Gene

GenomeRNAi human phenotypes for VPS13C:
genes like me logo Genes that share phenotypes with VPS13C: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS13C Gene

Localization for VPS13C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS13C Gene COMPARTMENTS Subcellular localization image for VPS13C gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VPS13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0019898 extrinsic component of membrane IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VPS13C: view

Pathways for VPS13C Gene

SuperPathways for VPS13C Gene

No Data Available

Interacting Proteins for VPS13C Gene

Gene Ontology (GO) - Biological Process for VPS13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006623 protein targeting to vacuole IBA --
GO:0045053 protein retention in Golgi apparatus IBA --
genes like me logo Genes that share ontologies with VPS13C: view

No data available for Pathways by source for VPS13C Gene

Transcripts for VPS13C Gene

Unigene Clusters for VPS13C Gene

Vacuolar protein sorting 13 homolog C (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS13C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2: - -
SP3:
SP4: - -
SP5:
SP6:

ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60a · 60b ^ 61 ^ 62 ^ 63 ^ 64 ^ 65 ^ 66a · 66b ^ 67 ^ 68 ^ 69 ^ 70 ^ 71 ^ 72 ^ 73 ^ 74 ^ 75 ^ 76 ^
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:

ExUns: 77 ^ 78 ^ 79 ^ 80 ^ 81 ^ 82 ^ 83a · 83b ^ 84 ^ 85 ^
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for VPS13C Gene

GeneLoc Exon Structure for
VPS13C
ECgene alternative splicing isoforms for
VPS13C

Expression for VPS13C Gene

mRNA expression in normal human tissues for VPS13C Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VPS13C Gene

SOURCE GeneReport for Unigene cluster for VPS13C Gene Hs.511668

mRNA Expression by UniProt/SwissProt for VPS13C Gene

Q709C8-VP13C_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with VPS13C: view

Orthologs for VPS13C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VPS13C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS13C 36
  • 99.4 (n)
  • 99.12 (a)
VPS13C 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VPS13C 36
  • 89.67 (n)
  • 87.36 (a)
VPS13C 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS13C 36
  • 91.07 (n)
  • 89.83 (a)
VPS13C 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps13c 36
  • 84.42 (n)
  • 86.61 (a)
Vps13c 16
Vps13c 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS13C 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS13C 37
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves VPS13C 36
  • 71.5 (n)
  • 69.24 (a)
VPS13C 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS13C 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vps13c 36
  • 65.85 (n)
  • 64.52 (a)
zebrafish
(Danio rerio)
Actinopterygii CR388046.3 37
  • 59 (a)
OneToOne
LOC798746 36
  • 62.01 (n)
  • 60.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vps13 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T08G11.1 37
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS13 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToMany
Species with no ortholog for VPS13C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VPS13C Gene

ENSEMBL:
Gene Tree for VPS13C (if available)
TreeFam:
Gene Tree for VPS13C (if available)

Paralogs for VPS13C Gene

Paralogs for VPS13C Gene

Selected SIMAP similar genes for VPS13C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VPS13C: view

Variants for VPS13C Gene

Sequence variations from dbSNP and Humsavar for VPS13C Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs15602 -- 61,954,529(-) GAAAT(A/C)TCTAT synonymous-codon, reference
rs725174 -- 62,021,218(-) TTAGT(A/G)TCTCC intron-variant
rs933807 -- 61,982,741(+) AGAAA(C/G)GAAGA intron-variant
rs957348 -- 61,935,700(+) GCTTA(C/T)GCAAT intron-variant
rs963023 -- 61,919,191(+) CAGAA(C/T)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS13C Gene

Variant ID Type Subtype PubMed ID
dgv2393n71 CNV Loss 21882294
dgv152n21 CNV Gain 19592680
nsv521334 CNV Loss 19592680
dgv2394n71 CNV Loss 21882294
dgv2395n71 CNV Loss 21882294
dgv2396n71 CNV Loss 21882294
nsv457176 CNV Gain 19166990
esv2749762 CNV Deletion 23290073
nsv904295 CNV Loss 21882294
nsv471247 CNV Gain 18288195
nsv827348 CNV Gain 20364138
nsv457177 CNV Loss 19166990
esv2582405 CNV Deletion 19546169
esv273087 CNV Insertion 20981092
esv270546 CNV Insertion 20981092
esv1275705 CNV Insertion 17803354
nsv457178 CNV Loss 19166990

Relevant External Links for VPS13C Gene

HapMap Linkage Disequilibrium report
VPS13C
Human Gene Mutation Database (HGMD)
VPS13C

Disorders for VPS13C Gene

(1) University of Copenhagen DISEASES for VPS13C Gene

Relevant External Links for VPS13C

Genetic Association Database (GAD)
VPS13C
Human Genome Epidemiology (HuGE) Navigator
VPS13C
genes like me logo Genes that share disorders with VPS13C: view

No data available for UniProtKB/Swiss-Prot for VPS13C Gene

Publications for VPS13C Gene

  1. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PMID: 20081857) Saxena R. … Watanabe R.M. (Nat. Genet. 2010) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Analysis of the human VPS13 gene family. (PMID: 15498460) Velayos-Baeza A. … Monaco A.P. (Genomics 2004) 3 4
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4

Products for VPS13C Gene

Sources for VPS13C Gene

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