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VPS13A Gene

protein-coding GIFtS: 57

GC09P078982

vacuolar protein sorting 13 homolog A (S. cerevisiae)
(Previous names: chorea acanthocytosis, vacuolar protein sorting 13A (yeast) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CHAC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CHAC ^², ³, ⁵
CHOREIN ^²
Chorein ^³
FLJ42030 ^²
KIAA0986 ^¹, ², ³

Descriptions
Chorea-acanthocytosis protein ^³
chorea acanthocytosis ^¹
vacuolar protein sorting 13 homolog A (S. cerevisiae) ^²
vacuolar protein sorting 13A ^²
vacuolar protein sorting 13A (yeast) ^¹

External Ids
HGNC: 1908¹
Entrez Gene: 23230²
UniProtKB: Q96RL7³
Ensembl: ENSG00000197969⁷

Search outside databases for aliases for VPS13A gene

Previous GC identifers: GC09P075249 GC09P077021

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for VPS13A:

The protein encoded by this gene may control steps in the cycling of proteins through the

trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause

the autosomal recessive disorder, chorea-acanthocytosis. Alternative splicing of this gene results

in multiple transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: VP13A_HUMAN, Q96RL7

Function: May play a role in the control of protein cycling through the trans-Golgi network to

early and late endosomes, lysosomes and plasma membrane

Gene Wiki entry for VPS13A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VPS13A gene

Entrez Gene cytogenetic band: 9q21 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21

VPS13A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P078982: (about GC identifiers)

Start:	78,982,181 bp from pter
End:	79,222,219 bp from pter
Size:	240,039 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_023935.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VP13A_HUMAN, Q96RL7 (See protein sequence)

Recommended Name: Vacuolar protein sorting-associated protein 13A

Size: 3174 amino acids; 360276 Da

Sequence caution: Sequence=AAH20576.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Secondary accessions: Q5JSX9 Q5JSY0 Q5VYR5 Q702P4 Q709D0 Q86YF8 Q96S61 Q9H995 Q9Y2J1

Alternative splicing: 4 isoforms: Q96RL7-1 Q96RL7-2 Q96RL7-3 Q96RL7-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001018047.1 NP_001018048.1 NP_056001.1 NP_150648.2

ENSEMBL proteins:

ENSP00000365821 ENSP00000348011 ENSP00000349985 ENSP00000365834 ENSP00000353422 ENSP00000365823

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Chorein)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	NAS	11381254

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Antibodies for VPS13A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for VPS13A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Chorein), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for VPS13A

Assays for VPS13A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96RL7

ProtoNet protein and cluster: Q96RL7

1 Blocks protein family: IPB009543 Protein of unknown function DUF1162

UniProtKB/Swiss-Prot: VP13A_HUMAN, Q96RL7

Similarity: Belongs to the VPS13 family

Similarity: Contains 10 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VPS13A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_033305

Applied Biosystems Silencer® siRNAs for VPS13A

Sigma-Aldrich siRNA for VPS13A

Sigma-Aldrich shRNA for VPS13A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001018037
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001018037
untagged cDNA clones in CMV expression vector (see all 4): NM_001018037

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_033305

UniProtKB/Swiss-Prot: VP13A_HUMAN, Q96RL7

Function: May play a role in the control of protein cycling through the trans-Golgi network to

early and late endosomes, lysosomes and plasma membrane

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vps13a):

behavior/neurological

hematopoietic system

nervous system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17474147

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Interacting proteins for VPS13A (ENSP00000353422³ Q96RL7¹) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	EBI-1752583, EBI-375543
FYN	P06241¹	EBI-1752583, EBI-515315
GRB2	P62993¹	EBI-1752583, EBI-401755
NCK1	P16333¹	EBI-1752583, EBI-389883
PIK3R1	P27986¹	EBI-1752583, EBI-79464

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006895	Golgi to endosome transport	NAS	11381253
GO:0008104	protein localization	NAS	11381254
GO:0015031	protein transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VPS13A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VPS13A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_033305

Sigma-Aldrich siRNA for VPS13A

Sigma-Aldrich shRNA for VPS13A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001018037 NM_001018038 NM_015186 NM_033305

REFSEQ mRNAs for VPS13A gene (4 alternative transcripts):

NM_001018037.1 NM_001018038.2 NM_015186.3 NM_033305.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001018037 NM_001018038 NM_015186 NM_033305

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001018037
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001018037
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001018037

Additional cDNA sequence:

AB023203.1 AB054005.1 AF337532.1 AJ608769.1 AJ626859.1 AK000273.1 AK022967.1 AK027023.1

AK124024.1 BC020576.1 BC041852.1

10 DOTS entries:

DT.100775273 DT.310392 DT.100707617 DT.97795858 DT.440997 DT.97803626 DT.101981083 DT.40208402

DT.86851769 DT.87046558

24/142 AceView cDNA sequences (see all 142 ):

AA132420 BQ718291 AA702210 AW301250 CB131398 AJ430440 BM126912 BQ011213

AK124024 NM_015186 AW967417 BU902765 AB023203 AI700589 BX111825 AJ608769

CA406082 AA573476 BQ185252 BM837858 AW189007 BE348288 AW301542 AI202451

highest scoring ESTs for VPS13A:

AI084224 AA228874 AA328381 AA513312 AA702210 AA830309 AA888785 AB023203 AI218624 AI279826

Unigene Cluster for VPS13A:

Vacuolar protein sorting 13 homolog A (S. cerevisiae)

Hs.459790 [show with all ESTs]

Unigene Representative Sequence: AF337532

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for VPS13A (see all 9 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21	^	22	^	23	^	24	^	25a	·
SP1:																									-
SP2:
SP3:
SP4:
SP5:

ExUns:	25b	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33	^	34
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for VPS13A

6 Ensembl transcripts including schematic representations:

ENST00000376634 ENST00000355766 ENST00000357409 ENST00000376646 ENST00000360280 ENST00000376636

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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VPS13A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VPS13A

¹ / ² / ³

14 probe-sets matching VPS13A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55431_at²^{, 3}	U95-B	1	1.00	1.00	0.92	0.90	AI218624	0.80	1.00	0.91	1
54521_g_at²^{, 3}	U95-B	1	1.00	1.00	0.90	1.12	AI084224	1.00	1.00	1.00	1
40001_r_at²^{, 3}	U95-A	1	1.00	1.00	0.18	0.17	AB023203	0.80	1.00	0.91	1
54520_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.22	AI084224	1.00	1.00	1.00	1
40000_f_at²^{, 3}	U95-A	1	1.00	1.00	0.55	0.80	AB023203	0.80	1.00	0.91	1
55062_at²^{, 3}	U95-C	1	0.94	1.00	0.91	0.97	AI301099	0.60	1.00	0.82	1
227988_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW629014	0.80	1.00	0.91	1
214785_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB023203	0.80	1.00	0.91	1
227987_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW629014	0.80	1.00	0.91	1
214852_x_at²^{, 3}	U133-A	1	0.64	1.00	--	--	BF573874	0.40	1.00	0.76	1
227988_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214785_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227987_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214852_x_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

GeneDecks VPS13A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.459790
Expression variation in blood from EXPOLDB for VPS13A
UniProtKB/Swiss-Prot: VP13A_HUMAN, Q96RL7
Tissue specificity: Widely expressed. Higher expression is found in brain, heart, skeletal muscle
and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VPS13A gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VPS13A¹	--	vacuolar protein sorting 13 homolog A (S. cerevisiae)	89.98(n) 87.99(a)	476319 XM_533522.2 XP_533522.2
chimpanzee (Pan troglodytes)	VPS13A¹	--	vacuolar protein sorting 13 homolog A (S. cerevisiae)	99.76(n) 99.65(a)	464538 XM_001148547.1 XP_001148547.1
rat (Rattus norvegicus)	Vps13a¹	--	vacuolar protein sorting 13 homolog A (S. cerevisiae)	85.57(n) 84.59(a)	309243 XM_219672.4 XP_219672.4
mouse (Mus musculus)	Vps13a^{1, 5}	19⁵	vacuolar protein sorting 13A (yeast)^{1, 5}	85.2(n)¹ 84.55(a)¹	271564¹ NM_173028.3¹ NP_766616.2¹ AA574646⁵ AA797756⁵ (see all 37)
zebrafish (Danio rerio)	chac²	--	chorea acanthocytosis	74.43(n)	378837 AF533660.1

About this table Species with no ortholog for VPS13A

ENSEMBL Gene Tree for VPS13A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VPS13A gene

VPS13D² VPS13C²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1120 NCBI SNPs in VPS13A are shown (see all 1120 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 296)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9186^1,2	A,C,F,H,O	79221766(+)	`CAGCTT/CATCAC`	2	--	ut3¹		14	MN EA NA EU WA	2638
	rs7043951^1,2	A,C,F,H	78980364(+)	`TCAAAC/GAATGA`	4	--	ng5¹		11	EU EA WA NA	962
	rs10869921^1,2	A,C,F,H	79187701(+)	`TGGTTT/CAGAGG`	4	--	int¹ ut3¹		4	EU EA WA	416
	rs1934728^1,2	A,C,F,H	79187932(-)	`AGAAAG/CAGTTA`	4	--	int¹ ng3¹ trp³		13	NS EU EA WA	942
	rs989391^1,2	A,C,F,H	79221307(+)	`GAATTG/ATACTT`	2	--	ut3¹ ese³		8	MN NA EU EA WA	746
	rs12349390^1,2	A,C,F,H	79188161(+)	`TCACCC/TATGGC`	4	--	int¹ ng3¹		8	EU EA WA	838
	rs13286867^1,2	C,F,H	79222120(+)	`GCTGAA/CCAAAT`	2	--	ut3¹ ese³		16	EA NA EU WA	1472
	rs17723855^1,2	C,F,H	78980675(+)	`ACTTAT/CTTCTA`	4	--	ng5¹		15	NA EU EA WA	1388
	rs17785751^1,2	C,F,H	78980245(+)	`GAAGGT/CATACA`	4	--	ng5¹		15	NA EU EA WA	1380
	rs12343797^1,2	C,F,H	79220964(+)	`TACCCG/AGTTTT`	2	--	ut3¹ ese³		11	NA EU EA WA	980

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HapMap Linkage Disequilibrium images for VPS13A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605978 disorders: 200150

UniProtKB/Swiss-Prot: VP13A_HUMAN, Q96RL7

Defects in VPS13A are the cause of chorea-acanthocytosis (CHAC) [MIM:200150]. CHAC is an

autosomal recessive neurodegenerative disorder characterized by the gradual onset of hyperkinetic

movements and abnormal erythrocyte morphology. Basal ganglia atrophy in the brain is a

pathological feature of the disease. Other clinical symptoms include psychiatric features,

epilepsy, peripheral neuropathy, myopathy and oral self-mutilation

4 Novoseek disease relationships for VPS13A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
chacs	99.02	38	12404112 (7), 14663054 (4), 17345646 (2), 17070500 (2) (see all 13)
chorea-acanthocytosis	98.59	14	14663054 (2), 12404112 (2), 15293285 (1), 15498460 (1) (see all 8)
huntington disease	64.94	3	17345646 (1), 15293285 (1), 11761473 (1)
neurodegenerative diseases	59.73	4	15914612 (1), 17070500 (1), 17673232 (1)

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GeneTests: VPS13A

Chorea-Acanthocytosis

Human Gene Mutation Database: VPS13A

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/29 PubMed articles for VPS13A gene (see all 29 ):

A conserved sorting-associated protein is mutant in chorea-acanthocytosis. (PubMed id 11381253)^{2, 3, 4} Rampoldi L....Monaco A.P. (2001)
Analysis of the human VPS13 gene family. (PubMed id 15498460)^{1, 3, 4} Velayos-Baeza A....Monaco A.P. (2004)
The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosis. (PubMed id 11381254)^{1, 3, 4} Ueno S.... Sano A. (2001)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{3, 4} Nagase T....Ohara O. (1999)
Chorea-acanthocytosis: genetic linkage to chromosome 9q21. (PubMed id 9382101)^{2, 3} Rubio J.P....Monaco A.P. (1997)
Clinical and molecular genetic assessment of a chorea-acanthocytosis pedigree. (PubMed id 17673232)^{1, 3} Ichiba M....Sano A. (2007)
Choreoacanthocytosis in a Mexican family. (PubMed id 17998451)^{1, 3} Ruiz-Sandoval J.L....Perez-Garcia G. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 23230	HGNC: 1908	AceView: VPS13A	Ensembl:ENSG00000197969	euGenes: HUgn23230
ECgene: VPS13A	H-InvDB: VPS13A

(According to HUGE)
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HUGE: KIAA0986

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=VPS13A

Licensable Technologies for VPS13A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for VPS13A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VPS13A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VPS13A		Antibodies for VPS13A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VPS13A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
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	Custom Service for Rabbit Pab from Full-length Protein

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VPS13A Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for VPS13A

Summaries
for VPS13A

Genomic Location
for VPS13A

Proteins
for VPS13A

Protein Domains/
Families
for VPS13A

Gene Function
for VPS13A

Pathways & Interactions
for VPS13A

Drugs & Compounds
for VPS13A

Transcripts
for VPS13A

Expression
for VPS13A

Orthologs
for VPS13A

Paralogs
for VPS13A

SNPs/Variants
for VPS13A

Disorders & Mutations
for VPS13A

Medical News
for VPS13A

Publications
for VPS13A

Search for VPS13A

Genome Databases showing VPS13A

Other Databases showing VPS13A

Specialized Databases showing VPS13A

Licensable Technologies
for VPS13A

Services
for VPS13A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VPS13A Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor VPS13A

Summariesfor VPS13A

Genomic Locationfor VPS13A

Proteinsfor VPS13A

Protein Domains/Familiesfor VPS13A

Gene Functionfor VPS13A

Pathways & Interactionsfor VPS13A

Drugs & Compoundsfor VPS13A

Transcriptsfor VPS13A

Expression for VPS13A

Orthologsfor VPS13A

Paralogsfor VPS13A

SNPs/Variantsfor VPS13A

Disorders & Mutationsfor VPS13A

Medical Newsfor VPS13A

Publicationsfor VPS13A

Search for VPS13A

Genome Databases showing VPS13A

Other Databases showing VPS13A

Specialized Databases showing VPS13A

Licensable Technologiesfor VPS13A

Servicesfor VPS13A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VPS13A

Summaries
for VPS13A

Genomic Location
for VPS13A

Proteins
for VPS13A

Protein Domains/
Families
for VPS13A

Gene Function
for VPS13A

Pathways & Interactions
for VPS13A

Drugs & Compounds
for VPS13A

Transcripts
for VPS13A

Expression
for VPS13A

Orthologs
for VPS13A

Paralogs
for VPS13A

SNPs/Variants
for VPS13A

Disorders & Mutations
for VPS13A

Medical News
for VPS13A

Publications
for VPS13A

Licensable Technologies
for VPS13A

Services
for VPS13A