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VPS11 Gene

protein-coding   GIFtS: 59
GCID: GC11P118938

Vacuolar Protein Sorting 11 Homolog (S. Cerevisiae)

(Previous name: vacuolar protein sorting 11 (yeast homolog))
  See VPS11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuolar Protein Sorting 11 Homolog (S. Cerevisiae)1 2     END12
RNF1082 3     PEP52
hVPS112 3     Vacuolar Protein Sorting Protein 112
RING Finger Protein 1082 3     Vacuolar Protein Sorting-Associated Protein 11 Homolog2
Vacuolar Protein Sorting 11 (Yeast Homolog)1     

External Ids:    HGNC: 145831   Entrez Gene: 558232   Ensembl: ENSG000001606957   OMIM: 6085495   UniProtKB: Q9H2703   

Export aliases for VPS11 gene to outside databases

Previous GC identifers: GC11P135438 GC11P120450 GC11P118972 GC11P118476 GC11P118443 GC11P114878


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VPS11 Gene:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct
organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved
in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The
mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast
counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Feb 2014)

GeneCards Summary for VPS11 Gene:
VPS11 (vacuolar protein sorting 11 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with VPS11 include chronic apical periodontitis, and acute intermittent porphyria. GO annotations related to this gene include nucleotide binding.

UniProtKB/Swiss-Prot: VPS11_HUMAN, Q9H270
Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
docking/fusion reactions of late endosomes/lysosomes

Gene Wiki entry for VPS11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the VPS11 gene promoter:
         TBP   p53   TFIID   MyoD   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPS11 promoter sequence
   Search Chromatin IP Primers for VPS11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPS11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

VPS11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118938:  view genomic region     (about GC identifiers)

Start:
118,938,403 bp from pter      End:
118,952,688 bp from pter
Size:
14,286 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VPS11_HUMAN, Q9H270 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 11 homolog  
Size: 941 amino acids; 107837 Da
Subunit: Part of large heterooligomeric complex together with VPS16, VPS18 and VPS33A. Interacts with STX7.
Interacts with ECM29
Sequence caution: Sequence=AAG23761.1; Type=Frameshift; Positions=439, 924; Sequence=BAB15320.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8WY89 Q96EP8 Q9H6D9 Q9HCS6

Explore the universe of human proteins at neXtProt for VPS11: NX_Q9H270

Explore proteomics data for VPS11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys84, Lys909
  • Modification sites at PhosphoSitePlus

  • See VPS11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001277114.1  NP_068375.3  

    ENSEMBL proteins: 
     ENSP00000475301  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 8):
     IPR001841 Znf_RING
     IPR016528 VPS11
     IPR013083 Znf_RING/FYVE/PHD
     IPR000547 Clathrin_H-chain/VPS_repeat
     IPR024763 VPS11_C

    Graphical View of Domain Structure for InterPro Entry Q9H270

    ProtoNet protein and cluster: Q9H270

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: VPS11_HUMAN, Q9H270
    Similarity: Belongs to the VPS11 family
    Similarity: Contains 2 CHCR (clathrin heavy-chain) repeats
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with VPS11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPS11_HUMAN, Q9H270
    Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane
    docking/fusion reactions of late endosomes/lysosomes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with VPS11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VPS11:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPS11
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    miRTarBase miRNAs that target VPS11:
    hsa-mir-331-3p (MIRT043320)

    Block miRNA regulation of human, mouse, rat VPS11 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate VPS11:
    hsa-miR-4290 hsa-miR-548q hsa-miR-3907
    SwitchGear 3'UTR luciferase reporter plasmidVPS11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPS11_HUMAN, Q9H270: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane;
    Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005768endosome IDA--
    GO:0005769early endosome ----
    GO:0005884actin filament ----
    GO:0030139endocytic vesicle IDA--

    Find genes that share ontologies with VPS11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including VPS11: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for VPS11

    Selected Interacting proteins for VPS11 (Q9H2701, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK3P274482, 3MINT-63626 I2D: score=5 
    TFAP2BQ924812, 3MINT-65489 I2D: score=4 
    VPS18Q9P2533I2D: score=9 
    VPS16Q9H2693I2D: score=7 
    BCAR1P569453I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--

    Find genes that share ontologies with VPS11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPS11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VPS11 gene (2 alternative transcripts): 
    NM_001290185.1  NM_021729.5  

    Unigene Cluster for VPS11:

    Vacuolar protein sorting 11 homolog (S. cerevisiae)
    Hs.234282  [show with all ESTs]
    Unigene Representative Sequence: AK302973
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531528 ENST00000527798(uc010ryy.2) ENST00000529838 ENST00000529545
    ENST00000526829 ENST00000530809 ENST00000534551 ENST00000524454 ENST00000300793(uc010ryx.2)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate VPS11:
    hsa-miR-4290 hsa-miR-548q hsa-miR-3907
    SwitchGear 3'UTR luciferase reporter plasmidVPS11 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat VPS11
      QuantiFast Probe-based Assays in human, mouse, rat VPS11

    Additional mRNA sequence: 

    AB027508.2 AF258558.1 AF308800.1 AK023279.1 AK026012.1 AK223158.1 AK302973.1 AL834218.1 
    BC012051.1 BC065563.1 

    10 DOTS entries:

    DT.216063  DT.100791149  DT.120685704  DT.95276364  DT.97845938  DT.120685716  DT.91990434  DT.100791144 
    DT.120685697  DT.91838291 

    Selected AceView cDNA sequences (see all 262):

    CD370480 CB528438 CO393555 CA414301 AI798031 BU078744 BE908869 BQ694057 
    AI419257 CB321845 BX345388 BF437133 CK823127 BE672488 BM676603 BF002246 
    AI703051 BM995369 C01014 AI200187 AA917367 BE552300 AA856628 BQ446529 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VPS11 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
    SP1:                          -     -           -                                                           -                             -                     
    SP2:                          -     -           -     -     -     -                                         -                             -                     
    SP3:                          -     -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                            -                                                                                                               

    ExUns: 14 ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for VPS11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPS11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGGGCTC
    VPS11 Expression
    About this image

    VPS11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPS11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.234282

    UniProtKB/Swiss-Prot: VPS11_HUMAN, Q9H270
    Tissue specificity: Ubiquitous. Expression was highest in heart and low in lung

        Pathway & Disease-focused RT2 Profiler PCR Array including VPS11: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPS11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPS11 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vps111 , 5 vacuolar protein sorting 11 (yeast)1, 5 91.36(n)1
    97.56(a)1
      9 (24.84 cM)5
    717321  NM_027889.11  NP_082165.11 
     443481065 
    chicken
    (Gallus gallus)
    Aves VPS111 vacuolar protein sorting 11 homolog (S. cerevisiae) 75.75(n)
    85.41(a)
      419702  XM_417847.3  XP_417847.2 
    lizard
    (Anolis carolinensis)
    Reptilia VPS116
    vacuolar protein sorting 11 homolog (S. cerevisiae...
    85(a)
    1 ↔ 1
    AAWZ02040519(4307-6803)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79682 Xenopus laevis transcribed sequence with moderate similarity more 77.45(n)    BJ075021.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vps111 vacuolar protein sorting 11 71.4(n)
    75.38(a)
      565852  NM_001037708.2  NP_001032797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG323506
    --
    20(a)
    1 ↔ 1
    3L(23140756-23143599)
    worm
    (Caenorhabditis elegans)
    Secernentea R06F6.23 vacuolar biogenesis protein (pep5) 27(a)   II(10788314-10793401)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP56
    Component of CORVET tethering complex; peripheral ...
    21(a)
    1 ↔ 1
    XIII(733545-736634) YMR231W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS111 VPS11 53.09(n)
    44.67(a)
      815065  NM_126544.2  NP_027676.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g03827001 Os04g0382700 51.8(n)
    43.89(a)
      4335642  NM_001059144.1  NP_001052609.1 


    ENSEMBL Gene Tree for VPS11 (if available)
    TreeFam Gene Tree for VPS11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VPS11 gene
    1 SIMAP similar gene for VPS11 using alignment to 2 protein entries:     VPS11_HUMAN (see all proteins):
    DKFZp564P2364

    Find genes that share paralogs with VPS11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPS11 (see all 484)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476863561,2
    C--118801170(+) ATGACC/TAGTAT 1 -- us2k10--------
    rs1424520081,2
    --118801215(+) CGCTCC/GCATTT 1 -- us2k10--------
    rs1498212121,2
    --118801238(+) AACAGC/TTGGTA 1 -- us2k10--------
    rs1814097011,2
    C--118801402(+) CCAGAC/TTGAGG 1 -- us2k10--------
    rs1175782231,2
    C,F--118801422(+) GATAAG/AAGGAG 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs4710001,2
    C,F,H--118801503(+) ACAGTC/TACGGT 1 -- us2k130Minor allele frequency- T:0.10NS EA NA MN WA CSA 2849
    rs1129146221,2
    C,F--118801505(+) AGTTAC/TGGTAC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1919713631,2
    --118801524(+) GCCCCC/TGCTCT 1 -- us2k10--------
    rs1818123821,2
    --118801592(+) GGGCCA/GGGTGC 1 -- us2k10--------
    rs1123605211,2
    C,F--118801607(+) GCTCAT/CGCCTG 1 -- us2k12Minor allele frequency- C:0.33CSA 3

    HapMap Linkage Disequilibrium report for VPS11 (118938403 - 118952688 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for VPS11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898416CNV Loss21882294

    Human Gene Mutation Database (HGMD): VPS11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPS11
    DNA2.0 Custom Variant and Variant Library Synthesis for VPS11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608549    OMIM disorders: --

    2 diseases for VPS11:    
    About MalaCards
    chronic apical periodontitis    acute intermittent porphyria

    1 disease from the University of Copenhagen DISEASES database for VPS11:
    Chronic apical periodontitis

    Find genes that share disorders with VPS11           About GenesLikeMe

    Genetic Association Database (GAD): VPS11
    Human Genome Epidemiology (HuGE) Navigator: VPS11 (3 documents)

    Export disorders for VPS11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPS11 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with VPS11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (J. Biol. Chem. 2010)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (Traffic 2007)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. (PubMed id 11382755)1, 2 Kim B.Y....Akazawa C. (J. Biol. Chem. 2001)
    8. Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33. (PubMed id 11250079)1, 2 Huizing M.... Kraemer H. (Gene 2001)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55823 HGNC: 14583 AceView: VPS11 Ensembl:ENSG00000160695 euGenes: HUgn55823
    ECgene: VPS11 H-InvDB: VPS11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VPS11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VPS11 gene:
    Search GeneIP for patents involving VPS11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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