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Aliases for VPS11 Gene

Aliases for VPS11 Gene

  • Vacuolar Protein Sorting 11 Homolog (S. Cerevisiae) 2 3
  • RING Finger Protein 108 3 4
  • RNF108 3 4
  • HVPS11 3 4
  • Vacuolar Protein Sorting-Associated Protein 11 Homolog 3
  • Vacuolar Protein Sorting 11 (Yeast Homolog) 2
  • END1 3
  • PEP5 3

External Ids for VPS11 Gene

Previous GeneCards Identifiers for VPS11 Gene

  • GC11P135438
  • GC11P120450
  • GC11P118972
  • GC11P118476
  • GC11P118443
  • GC11P118938
  • GC11P114878

Summaries for VPS11 Gene

Entrez Gene Summary for VPS11 Gene

  • Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for VPS11 Gene

VPS11 (Vacuolar Protein Sorting 11 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with VPS11 include chronic apical periodontitis. GO annotations related to this gene include nucleotide binding.

UniProtKB/Swiss-Prot for VPS11 Gene

  • May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.

Gene Wiki entry for VPS11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS11 Gene

Genomics for VPS11 Gene

Regulatory Elements for VPS11 Gene

Genomic Location for VPS11 Gene

Start:
119,067,692 bp from pter
End:
119,081,978 bp from pter
Size:
14,287 bases
Orientation:
Plus strand

Genomic View for VPS11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS11 Gene

Proteins for VPS11 Gene

  • Protein details for VPS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H270-VPS11_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 11 homolog
    Protein Accession:
    Q9H270
    Secondary Accessions:
    • Q8WY89
    • Q96EP8
    • Q9H6D9
    • Q9HCS6

    Protein attributes for VPS11 Gene

    Size:
    941 amino acids
    Molecular mass:
    107837 Da
    Quaternary structure:
    • Part of large heterooligomeric complex together with VPS16, VPS18 and VPS33A. Interacts with STX7. Interacts with ECM29.
    SequenceCaution:
    • Sequence=AAG23761.1; Type=Frameshift; Positions=439, 924; Evidence={ECO:0000305}; Sequence=BAB15320.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for VPS11 Gene

Proteomics data for VPS11 Gene at MOPED

Post-translational modifications for VPS11 Gene

  • Ubiquitination at Lys84 and Lys909
  • Modification sites at PhosphoSitePlus

Other Protein References for VPS11 Gene

No data available for DME Specific Peptides for VPS11 Gene

Domains for VPS11 Gene

Gene Families for VPS11 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for VPS11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H270

UniProtKB/Swiss-Prot:

VPS11_HUMAN :
  • Q9H270
Family:
  • Belongs to the VPS11 family.
Similarity:
  • Contains 2 CHCR (clathrin heavy-chain) repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with VPS11: view

Function for VPS11 Gene

Molecular function for VPS11 Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.

Gene Ontology (GO) - Molecular Function for VPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 22493164
GO:0008270 zinc ion binding IEA --
GO:0019905 syntaxin binding IDA 11382755
genes like me logo Genes that share ontologies with VPS11: view

Phenotypes for VPS11 Gene

GenomeRNAi human phenotypes for VPS11:
genes like me logo Genes that share phenotypes with VPS11: view

miRNA for VPS11 Gene

miRTarBase miRNAs that target VPS11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VPS11 Gene

Localization for VPS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS11 Gene

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPS11 Gene COMPARTMENTS Subcellular localization image for VPS11 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for VPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 11382755
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome IDA 20682791
GO:0005769 early endosome --
GO:0005770 late endosome IDA 11382755
genes like me logo Genes that share ontologies with VPS11: view

Pathways for VPS11 Gene

SuperPathways for VPS11 Gene

No Data Available

Interacting Proteins for VPS11 Gene

Gene Ontology (GO) - Biological Process for VPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with VPS11: view

No data available for Pathways by source for VPS11 Gene

Transcripts for VPS11 Gene

Unigene Clusters for VPS11 Gene

Vacuolar protein sorting 11 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7:
SP8: - -

ExUns: 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for VPS11 Gene

GeneLoc Exon Structure for
VPS11
ECgene alternative splicing isoforms for
VPS11

Expression for VPS11 Gene

mRNA expression in normal human tissues for VPS11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for VPS11 Gene

SOURCE GeneReport for Unigene cluster for VPS11 Gene Hs.234282

mRNA Expression by UniProt/SwissProt for VPS11 Gene

Q9H270-VPS11_HUMAN
Tissue specificity: Ubiquitous. Expression was highest in heart and low in lung
genes like me logo Genes that share expressions with VPS11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VPS11 Gene

Orthologs for VPS11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS11 35
  • 99.86 (n)
  • 99.89 (a)
cow
(Bos Taurus)
Mammalia VPS11 35
  • 92.45 (n)
  • 97.98 (a)
VPS11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPS11 35
  • 92.81 (n)
  • 98.19 (a)
VPS11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps11 35
  • 91.36 (n)
  • 97.56 (a)
Vps11 16
Vps11 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VPS11 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS11 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps11 35
  • 91.15 (n)
  • 98.18 (a)
chicken
(Gallus gallus)
Aves VPS11 35
  • 75.75 (n)
  • 85.41 (a)
VPS11 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS11 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7968 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9475 35
vps11 35
  • 72.05 (n)
  • 80.66 (a)
zebrafish
(Danio rerio)
Actinopterygii vps11 35
  • 71.4 (n)
  • 75.38 (a)
vps11 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002665 35
  • 51.9 (n)
  • 41.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32350 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vps-11 36
  • 26 (a)
OneToOne
R06F6.2 37
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP5 36
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS11 35
  • 53.09 (n)
  • 44.67 (a)
rice
(Oryza sativa)
Liliopsida Os04g0382700 35
  • 51.8 (n)
  • 43.89 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.8374 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05422 35
  • 48.2 (n)
  • 34.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for VPS11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for VPS11 Gene

ENSEMBL:
Gene Tree for VPS11 (if available)
TreeFam:
Gene Tree for VPS11 (if available)

Paralogs for VPS11 Gene

Selected SIMAP similar genes for VPS11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VPS11: view

No data available for Paralogs for VPS11 Gene

Variants for VPS11 Gene

Sequence variations from dbSNP and Humsavar for VPS11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4614 -- 119,081,661(-) TCTCT(C/T)GGTCC utr-variant-3-prime
rs15818 -- 119,081,463(-) AGCAC(C/T)TGAGC reference, missense
rs471000 -- 119,066,199(+) ACAGT(C/T)ACGGT upstream-variant-2KB
rs484263 -- 119,069,769(-) CGCCC(A/G)CCTCA intron-variant
rs540261 -- 119,076,924(-) ATCAC(A/G)TAGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for VPS11 Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294

Relevant External Links for VPS11 Gene

HapMap Linkage Disequilibrium report
VPS11
Human Gene Mutation Database (HGMD)
VPS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS11 Gene

Disorders for VPS11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for VPS11 Gene including...

Search for VPS11 Gene in MalaCards »

(1) University of Copenhagen DISEASES for VPS11 Gene

Relevant External Links for VPS11

Genetic Association Database (GAD)
VPS11
Human Genome Epidemiology (HuGE) Navigator
VPS11
genes like me logo Genes that share disorders with VPS11: view

No data available for UniProtKB/Swiss-Prot for VPS11 Gene

Publications for VPS11 Gene

  1. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2010) 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for VPS11 Gene

Sources for VPS11 Gene

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