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Aliases for VPS11 Gene

Aliases for VPS11 Gene

  • VPS11, CORVET/HOPS Core Subunit 2 3 5
  • RING Finger Protein 108 3 4
  • RNF108 3 4
  • HVPS11 3 4
  • Vacuolar Protein Sorting 11 Homolog (S. Cerevisiae) 2
  • Vacuolar Protein Sorting 11 (Yeast Homolog) 2
  • Vacuolar Protein Sorting 11 Homolog 3
  • VPS11 CORVET/HOPS Core Subunit 3
  • HLD12 3
  • END1 3
  • PEP5 3

External Ids for VPS11 Gene

Previous GeneCards Identifiers for VPS11 Gene

  • GC11P135438
  • GC11P120450
  • GC11P118972
  • GC11P118476
  • GC11P118443
  • GC11P118938
  • GC11P114878

Summaries for VPS11 Gene

Entrez Gene Summary for VPS11 Gene

  • Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for VPS11 Gene

VPS11 (VPS11, CORVET/HOPS Core Subunit) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and syntaxin binding.

UniProtKB/Swiss-Prot for VPS11 Gene

  • Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

Gene Wiki entry for VPS11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPS11 Gene

Genomics for VPS11 Gene

Regulatory Elements for VPS11 Gene

Promoters for VPS11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VPS11 on UCSC Golden Path with GeneCards custom track

Genomic Location for VPS11 Gene

Chromosome:
11
Start:
119,067,692 bp from pter
End:
119,081,978 bp from pter
Size:
14,287 bases
Orientation:
Plus strand

Genomic View for VPS11 Gene

Genes around VPS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPS11 Gene

Proteins for VPS11 Gene

  • Protein details for VPS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H270-VPS11_HUMAN
    Recommended name:
    Vacuolar protein sorting-associated protein 11 homolog
    Protein Accession:
    Q9H270
    Secondary Accessions:
    • Q8WY89
    • Q96EP8
    • Q9H6D9
    • Q9HCS6

    Protein attributes for VPS11 Gene

    Size:
    941 amino acids
    Molecular mass:
    107837 Da
    Quaternary structure:
    • Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuaole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:11382755, PubMed:20434987, PubMed:23351085, PubMed:23901104, PubMed:25266290, PubMed:25783203). Interacts with TGFBRAP1, MON1B, STX7, STX17, EZR, RDX, MSN, ECM29 (PubMed:11382755, PubMed:20682791, PubMed:21148287, PubMed:24554770, PubMed:25266290). Interacts with RAB5C (By similarity). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (By similarity).
    SequenceCaution:
    • Sequence=AAG23761.1; Type=Frameshift; Positions=439, 924; Evidence={ECO:0000305}; Sequence=BAB15320.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for VPS11 Gene

Proteomics data for VPS11 Gene at MOPED

Post-translational modifications for VPS11 Gene

  • Ubiquitination at Lys 84 and Lys 909
  • Modification sites at PhosphoSitePlus

Other Protein References for VPS11 Gene

Antibody Products

No data available for DME Specific Peptides for VPS11 Gene

Domains & Families for VPS11 Gene

Gene Families for VPS11 Gene

Suggested Antigen Peptide Sequences for VPS11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H270

UniProtKB/Swiss-Prot:

VPS11_HUMAN :
  • Belongs to the VPS11 family.
  • Contains 2 CHCR (clathrin heavy-chain) repeats.
Family:
  • Belongs to the VPS11 family.
Similarity:
  • Contains 2 CHCR (clathrin heavy-chain) repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with VPS11: view

Function for VPS11 Gene

Molecular function for VPS11 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

Gene Ontology (GO) - Molecular Function for VPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0030674 protein binding, bridging IBA --
genes like me logo Genes that share ontologies with VPS11: view
genes like me logo Genes that share phenotypes with VPS11: view

Animal Model Products

miRNA for VPS11 Gene

miRTarBase miRNAs that target VPS11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPS11 Gene

Localization for VPS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VPS11 Gene

Endosome. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.

Gene Ontology (GO) - Cellular Components for VPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 20682791
GO:0005769 colocalizes_with early endosome IDA 21148287
GO:0030123 AP-3 adaptor complex IEA --
GO:0030136 clathrin-coated vesicle IEA --
GO:0030139 endocytic vesicle IDA 20682791
genes like me logo Genes that share ontologies with VPS11: view

No data available for Subcellular locations from COMPARTMENTS for VPS11 Gene

Pathways & Interactions for VPS11 Gene

SuperPathways for VPS11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VPS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0035542 regulation of SNARE complex assembly IBA --
GO:1901998 toxin transport IEA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with VPS11: view

No data available for Pathways by source and SIGNOR curated interactions for VPS11 Gene

Drugs & Compounds for VPS11 Gene

No Compound Related Data Available

Transcripts for VPS11 Gene

Unigene Clusters for VPS11 Gene

Vacuolar protein sorting 11 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPS11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7:
SP8: - -

ExUns: 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for VPS11 Gene

GeneLoc Exon Structure for
VPS11
ECgene alternative splicing isoforms for
VPS11

Expression for VPS11 Gene

mRNA expression in normal human tissues for VPS11 Gene

Protein differential expression in normal tissues from HIPED for VPS11 Gene

This gene is overexpressed in Tonsil (40.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for VPS11 Gene



SOURCE GeneReport for Unigene cluster for VPS11 Gene Hs.234282

mRNA Expression by UniProt/SwissProt for VPS11 Gene

Q9H270-VPS11_HUMAN
Tissue specificity: Ubiquitous. Expression was highest in heart and low in lung.
genes like me logo Genes that share expression patterns with VPS11: view

Protein tissue co-expression partners for VPS11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VPS11 Gene

Orthologs for VPS11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VPS11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VPS11 35
  • 99.86 (n)
  • 99.89 (a)
cow
(Bos Taurus)
Mammalia VPS11 36
  • 98 (a)
OneToOne
VPS11 35
  • 92.45 (n)
  • 97.98 (a)
dog
(Canis familiaris)
Mammalia VPS11 35
  • 92.81 (n)
  • 98.19 (a)
VPS11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vps11 16
Vps11 36
  • 97 (a)
OneToOne
Vps11 35
  • 91.36 (n)
  • 97.56 (a)
oppossum
(Monodelphis domestica)
Mammalia VPS11 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VPS11 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vps11 35
  • 91.15 (n)
  • 98.18 (a)
chicken
(Gallus gallus)
Aves VPS11 35
  • 75.75 (n)
  • 85.41 (a)
VPS11 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VPS11 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7968 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9475 35
vps11 35
  • 72.05 (n)
  • 80.66 (a)
zebrafish
(Danio rerio)
Actinopterygii vps11 36
  • 74 (a)
OneToOne
vps11 35
  • 71.4 (n)
  • 75.38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002665 35
  • 51.9 (n)
  • 41.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32350 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vps-11 36
  • 26 (a)
OneToOne
R06F6.2 37
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP5 36
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS11 35
  • 53.09 (n)
  • 44.67 (a)
rice
(Oryza sativa)
Liliopsida Os04g0382700 35
  • 51.8 (n)
  • 43.89 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.8374 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05422 35
  • 48.2 (n)
  • 34.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for VPS11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for VPS11 Gene

ENSEMBL:
Gene Tree for VPS11 (if available)
TreeFam:
Gene Tree for VPS11 (if available)

Paralogs for VPS11 Gene

(1) SIMAP similar genes for VPS11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VPS11: view

No data available for Paralogs for VPS11 Gene

Variants for VPS11 Gene

Sequence variations from dbSNP and Humsavar for VPS11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11558589 - 119,079,170(-) GATGA(C/T)GGAGA nc-transcript-variant, reference, missense
rs471000 -- 119,066,199(+) ACAGT(C/T)ACGGT upstream-variant-2KB
rs540261 -- 119,076,924(-) ATCAC(A/G)TAGGA nc-transcript-variant, reference, synonymous-codon
rs563162 -- 119,074,199(+) cctgc(C/T)tcagt intron-variant
rs576110 -- 119,075,288(-) cccCA(A/G)CCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VPS11 Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294

Variation tolerance for VPS11 Gene

Gene Damage Index Score: 10.24; 90.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPS11 Gene

HapMap Linkage Disequilibrium report
VPS11
Human Gene Mutation Database (HGMD)
VPS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPS11 Gene

Disorders for VPS11 Gene

Relevant External Links for VPS11

Genetic Association Database (GAD)
VPS11
Human Genome Epidemiology (HuGE) Navigator
VPS11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPS11

No disorders were found for VPS11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPS11 Gene

Publications for VPS11 Gene

  1. Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes. (PMID: 25783203) Wartosch L. … Luzio J.P. (Traffic 2015) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. (PMID: 25266290) Perini E.D. … Zerial M. (Traffic 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for VPS11 Gene

Sources for VPS11 Gene

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