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Aliases for VPREB3 Gene

Aliases for VPREB3 Gene

  • Pre-B Lymphocyte 3 2 3
  • N27C7-2 3 4
  • Pre-B Lymphocyte Protein 3 3
  • Pre-B Lymphocyte Gene 3 3
  • Protein VPreB3 4
  • 8HS20 3

External Ids for VPREB3 Gene

Previous GeneCards Identifiers for VPREB3 Gene

  • GC22M020791
  • GC22M022419
  • GC22M024094
  • GC22M007083

Summaries for VPREB3 Gene

Entrez Gene Summary for VPREB3 Gene

  • The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells. [provided by RefSeq, Sep 2008]

GeneCards Summary for VPREB3 Gene

VPREB3 (Pre-B Lymphocyte 3) is a Protein Coding gene. An important paralog of this gene is VPREB1.

UniProtKB/Swiss-Prot for VPREB3 Gene

  • Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells

Gene Wiki entry for VPREB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPREB3 Gene

Genomics for VPREB3 Gene

Regulatory Elements for VPREB3 Gene

Genomic Location for VPREB3 Gene

23,752,743 bp from pter
23,754,468 bp from pter
1,726 bases
Minus strand

Genomic View for VPREB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPREB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPREB3 Gene

Proteins for VPREB3 Gene

  • Protein details for VPREB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-B lymphocyte protein 3
    Protein Accession:
    Secondary Accessions:
    • B2R587

    Protein attributes for VPREB3 Gene

    123 amino acids
    Molecular mass:
    13710 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VPREB3 Gene

Proteomics data for VPREB3 Gene at MOPED

Post-translational modifications for VPREB3 Gene

No Post-translational modifications

Other Protein References for VPREB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for VPREB3 Gene

Domains for VPREB3 Gene

Gene Families for VPREB3 Gene

Protein Domains for VPREB3 Gene

Suggested Antigen Peptide Sequences for VPREB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with VPREB3: view

Function for VPREB3 Gene

Molecular function for VPREB3 Gene

UniProtKB/Swiss-Prot Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells

Gene Ontology (GO) - Molecular Function for VPREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VPREB3: view

Animal Model Products

miRNA for VPREB3 Gene

miRTarBase miRNAs that target VPREB3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPREB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for VPREB3 Gene

Localization for VPREB3 Gene

Subcellular locations from

Jensen Localization Image for VPREB3 Gene COMPARTMENTS Subcellular localization image for VPREB3 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VPREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum NAS 10702669
genes like me logo Genes that share ontologies with VPREB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VPREB3 Gene

Pathways for VPREB3 Gene

SuperPathways for VPREB3 Gene

No Data Available

Interacting Proteins for VPREB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000248948 Q9UKI3-VPRE3_HUMAN for VPREB3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for VPREB3 Gene


No data available for Pathways by source for VPREB3 Gene

Transcripts for VPREB3 Gene

mRNA/cDNA for VPREB3 Gene

Unigene Clusters for VPREB3 Gene

Pre-B lymphocyte 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPREB3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPREB3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP2: -

Relevant External Links for VPREB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VPREB3 Gene

mRNA expression in normal human tissues for VPREB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VPREB3 Gene

This gene is overexpressed in Spleen (15.6), Small Intestine - Terminal Ileum (13.4), and Whole Blood (4.9).

SOURCE GeneReport for Unigene cluster for VPREB3 Gene Hs.136713

mRNA Expression by UniProt/SwissProt for VPREB3 Gene

Tissue specificity: Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node
genes like me logo Genes that share expressions with VPREB3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for VPREB3 Gene

Orthologs for VPREB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VPREB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VPREB3 35
  • 77.97 (n)
  • 70.34 (a)
  • 65 (a)
(Canis familiaris)
Mammalia VPREB3 35
  • 82.63 (n)
  • 79.83 (a)
  • 79 (a)
(Mus musculus)
Mammalia Vpreb3 35
  • 71.86 (n)
  • 67.21 (a)
Vpreb3 16
Vpreb3 36
  • 67 (a)
(Pan troglodytes)
Mammalia VPREB3 35
  • 99.46 (n)
  • 98.37 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Vpreb3 35
  • 73.81 (n)
  • 66.33 (a)
(Gallus gallus)
Aves VPREB3 35
  • 63.61 (n)
  • 56.88 (a)
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
-- 36
  • 30 (a)
Species with no ortholog for VPREB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VPREB3 Gene

Gene Tree for VPREB3 (if available)
Gene Tree for VPREB3 (if available)

Paralogs for VPREB3 Gene

genes like me logo Genes that share paralogs with VPREB3: view

Variants for VPREB3 Gene

Sequence variations from dbSNP and Humsavar for VPREB3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1076123 -- 23,754,596(+) TCATG(C/T)GCAGT upstream-variant-2KB
rs2070453 -- 23,754,213(+) GGACC(G/T)GCCCT intron-variant
rs2070454 -- 23,754,487(+) GACTG(A/C)GGAAG upstream-variant-2KB
rs2298373 -- 23,754,771(+) acaca(C/T)acaca upstream-variant-2KB
rs4822437 -- 23,755,785(+) ccccc(C/T)actgt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VPREB3 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914597 CNV Loss 21882294

Relevant External Links for VPREB3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPREB3 Gene

Disorders for VPREB3 Gene

No disorders were found for VPREB3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for VPREB3 Gene

Publications for VPREB3 Gene

  1. VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse. (PMID: 10702669) Rosnet O. … Schiff C. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells. (PMID: 14670953) Rosnet O. … Schiff C. (J. Biol. Chem. 2004) 2 3
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for VPREB3 Gene

Sources for VPREB3 Gene

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