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Aliases for VPREB3 Gene

Aliases for VPREB3 Gene

  • Pre-B Lymphocyte 3 2 3 5
  • N27C7-2 3 4
  • Pre-B Lymphocyte Gene 3 3
  • Protein VPreB3 4
  • 8HS20 3

External Ids for VPREB3 Gene

Previous GeneCards Identifiers for VPREB3 Gene

  • GC22M020791
  • GC22M022419
  • GC22M024094
  • GC22M007083

Summaries for VPREB3 Gene

Entrez Gene Summary for VPREB3 Gene

  • The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]

GeneCards Summary for VPREB3 Gene

VPREB3 (Pre-B Lymphocyte 3) is a Protein Coding gene. An important paralog of this gene is IGLV3-12.

UniProtKB/Swiss-Prot for VPREB3 Gene

  • Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.

Gene Wiki entry for VPREB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPREB3 Gene

Genomics for VPREB3 Gene

Regulatory Elements for VPREB3 Gene

Enhancers for VPREB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VPREB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for VPREB3 Gene

Chromosome:
22
Start:
23,752,743 bp from pter
End:
23,754,468 bp from pter
Size:
1,726 bases
Orientation:
Minus strand

Genomic View for VPREB3 Gene

Genes around VPREB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPREB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPREB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPREB3 Gene

Proteins for VPREB3 Gene

  • Protein details for VPREB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKI3-VPRE3_HUMAN
    Recommended name:
    Pre-B lymphocyte protein 3
    Protein Accession:
    Q9UKI3
    Secondary Accessions:
    • B2R587

    Protein attributes for VPREB3 Gene

    Size:
    123 amino acids
    Molecular mass:
    13710 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VPREB3 Gene

Proteomics data for VPREB3 Gene at MOPED

Post-translational modifications for VPREB3 Gene

No Post-translational modifications

Other Protein References for VPREB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPREB3 Gene

Domains & Families for VPREB3 Gene

Gene Families for VPREB3 Gene

Protein Domains for VPREB3 Gene

Suggested Antigen Peptide Sequences for VPREB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKI3

UniProtKB/Swiss-Prot:

VPRE3_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with VPREB3: view

Function for VPREB3 Gene

Molecular function for VPREB3 Gene

UniProtKB/Swiss-Prot Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells.

Phenotypes for VPREB3 Gene

genes like me logo Genes that share phenotypes with VPREB3: view

Animal Model Products

miRNA for VPREB3 Gene

miRTarBase miRNAs that target VPREB3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VPREB3 Gene

Localization for VPREB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VPREB3 Gene COMPARTMENTS Subcellular localization image for VPREB3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VPREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum NAS 10702669
genes like me logo Genes that share ontologies with VPREB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VPREB3 Gene

Pathways & Interactions for VPREB3 Gene

SuperPathways for VPREB3 Gene

No Data Available

Interacting Proteins for VPREB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000248948%0d%0a9606.ENSP00000385361%0d%0a9606.ENSP00000356574%0d%0a
Selected Interacting proteins: ENSP00000248948 Q9UKI3-VPRE3_HUMAN for VPREB3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for VPREB3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VPREB3 Gene

Drugs & Compounds for VPREB3 Gene

No Compound Related Data Available

Transcripts for VPREB3 Gene

mRNA/cDNA for VPREB3 Gene

Unigene Clusters for VPREB3 Gene

Pre-B lymphocyte 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VPREB3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:
SP2: -

Relevant External Links for VPREB3 Gene

GeneLoc Exon Structure for
VPREB3
ECgene alternative splicing isoforms for
VPREB3

Expression for VPREB3 Gene

mRNA expression in normal human tissues for VPREB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VPREB3 Gene

This gene is overexpressed in Spleen (x15.6), Small Intestine - Terminal Ileum (x13.4), and Whole Blood (x4.9).

SOURCE GeneReport for Unigene cluster for VPREB3 Gene Hs.136713

mRNA Expression by UniProt/SwissProt for VPREB3 Gene

Q9UKI3-VPRE3_HUMAN
Tissue specificity: Expressed in B-cell precursors. Expressed in fetal liver, bone marrow, spleen and lymph node.
genes like me logo Genes that share expression patterns with VPREB3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for VPREB3 Gene

Orthologs for VPREB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VPREB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VPREB3 35
  • 77.97 (n)
  • 70.34 (a)
VPREB3 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VPREB3 35
  • 82.63 (n)
  • 79.83 (a)
VPREB3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vpreb3 35
  • 71.86 (n)
  • 67.21 (a)
Vpreb3 16
Vpreb3 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VPREB3 35
  • 99.46 (n)
  • 98.37 (a)
VPREB3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vpreb3 35
  • 73.81 (n)
  • 66.33 (a)
chicken
(Gallus gallus)
Aves VPREB3 35
  • 63.61 (n)
  • 56.88 (a)
VPREB3 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
Species with no ortholog for VPREB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VPREB3 Gene

ENSEMBL:
Gene Tree for VPREB3 (if available)
TreeFam:
Gene Tree for VPREB3 (if available)

Paralogs for VPREB3 Gene

genes like me logo Genes that share paralogs with VPREB3: view

Variants for VPREB3 Gene

Sequence variations from dbSNP and Humsavar for VPREB3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs34372784 - 23,754,354(+) GCACC(A/G)GCAGG reference, missense
rs2298373 -- 23,754,771(+) acaca(C/T)acaca upstream-variant-2KB
rs9608180 -- 23,756,250(+) tgatc(C/T)gcccg upstream-variant-2KB
rs138991103 -- 23,754,770(+) ACACA(-/AT/CC)TACAC upstream-variant-2KB
rs9612418 -- 23,754,828(+) aatct(C/T)ggctg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VPREB3 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914597 CNV Loss 21882294

Variation tolerance for VPREB3 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VPREB3 Gene

Disorders for VPREB3 Gene

Relevant External Links for VPREB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VPREB3

No disorders were found for VPREB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VPREB3 Gene

Publications for VPREB3 Gene

  1. VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse. (PMID: 10702669) Rosnet O. … Schiff C. (Cytogenet. Cell Genet. 1999) 2 3 4 23 67
  2. Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells. (PMID: 14670953) Rosnet O. … Schiff C. (J. Biol. Chem. 2004) 2 3
  3. A novel gene product associated with mu chains in immature B cells. (PMID: 8491176) Shirasawa T. … Takemori T. (EMBO J. 1993) 3 23
  4. Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues. (PMID: 25861052) Felizola S.J. … Sasano H. (Endocr. Pathol. 2015) 3
  5. The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas. (PMID: 24493312) Soldini D. … Tinguely M. (Hematol Oncol 2014) 3

Products for VPREB3 Gene

Sources for VPREB3 Gene

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