Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VPREB1 Gene

Aliases for VPREB1 Gene

  • Pre-B Lymphocyte 1 2 3
  • VPREB 3 4 6
  • CD179 Antigen-Like Family Member A 3 4
  • V(Pre)B Protein 3 4
  • IGI 3 6
  • Immunoglobulin Iota Chain 3
  • CD179a Antigen 4
  • Protein VPreB1 4
  • VpreB Protein 4
  • CD179a 3
  • IGVPB 3

External Ids for VPREB1 Gene

Previous GeneCards Identifiers for VPREB1 Gene

  • GC22P019297
  • GC22P020923
  • GC22P022600
  • GC22P005557

Summaries for VPREB1 Gene

Entrez Gene Summary for VPREB1 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for VPREB1 Gene

VPREB1 (Pre-B Lymphocyte 1) is a Protein Coding gene. Diseases associated with VPREB1 include conidiobolomycosis and common variable immunodeficiency. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLV4-60.

UniProtKB/Swiss-Prot for VPREB1 Gene

  • Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation

Gene Wiki entry for VPREB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPREB1 Gene

Genomics for VPREB1 Gene

Regulatory Elements for VPREB1 Gene

Genomic Location for VPREB1 Gene

22,244,675 bp from pter
22,245,515 bp from pter
841 bases
Plus strand

Genomic View for VPREB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VPREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPREB1 Gene

Proteins for VPREB1 Gene

  • Protein details for VPREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin iota chain
    Protein Accession:
    Secondary Accessions:
    • B5MCG2

    Protein attributes for VPREB1 Gene

    145 amino acids
    Molecular mass:
    16605 Da
    Quaternary structure:
    • Associates non-covalently with IGLL1.

    Three dimensional structures from OCA and Proteopedia for VPREB1 Gene

neXtProt entry for VPREB1 Gene

Proteomics data for VPREB1 Gene at MOPED

Post-translational modifications for VPREB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPREB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPREB1 Gene

Domains for VPREB1 Gene

Gene Families for VPREB1 Gene

  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for VPREB1 Gene

Suggested Antigen Peptide Sequences for VPREB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P12018
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with VPREB1: view

Function for VPREB1 Gene

Molecular function for VPREB1 Gene

GENATLAS Biochemistry:
immunoglobulin-like V gene,expressed in pre-B cells
UniProtKB/Swiss-Prot Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation

Gene Ontology (GO) - Molecular Function for VPREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with VPREB1: view

Phenotypes for VPREB1 Gene

genes like me logo Genes that share phenotypes with VPREB1: view

Animal Models for VPREB1 Gene

MGI Knock Outs for VPREB1:

Animal Model Products

CRISPR Products

miRNA for VPREB1 Gene

miRTarBase miRNAs that target VPREB1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPREB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VPREB1 Gene

Localization for VPREB1 Gene

Subcellular locations from

Jensen Localization Image for VPREB1 Gene COMPARTMENTS Subcellular localization image for VPREB1 gene
Compartment Confidence
extracellular 5
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VPREB1 Gene

Pathways for VPREB1 Gene

SuperPathways for VPREB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VPREB1 Gene


No data available for Pathways by source for VPREB1 Gene

Compounds for VPREB1 Gene

(1) Novoseek inferred chemical compound relationships for VPREB1 Gene

Compound -log(P) Hits PubMed IDs
probenecid 69.1 3
genes like me logo Genes that share compounds with VPREB1: view

Transcripts for VPREB1 Gene

mRNA/cDNA for VPREB1 Gene

(3) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VPREB1 Gene

Pre-B lymphocyte 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VPREB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPREB1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -

Relevant External Links for VPREB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VPREB1 Gene

mRNA expression in normal human tissues for VPREB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VPREB1 Gene

SOURCE GeneReport for Unigene cluster for VPREB1 Gene Hs.247979

mRNA Expression by UniProt/SwissProt for VPREB1 Gene

Tissue specificity: Only expressed by pre-B-cells
genes like me logo Genes that share expressions with VPREB1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Expression partners for VPREB1 Gene

Orthologs for VPREB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VPREB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia VPREB1 35
  • 80.44 (n)
  • 71.07 (a)
  • 62 (a)
(Mus musculus)
Mammalia Vpreb2 35
  • 83.75 (n)
  • 77.69 (a)
Vpreb1 16
Vpreb1 36
  • 73 (a)
Vpreb2 36
  • 73 (a)
(Pan troglodytes)
Mammalia VPREB1 35
  • 98.62 (n)
  • 97.93 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Vpreb2 35
  • 81.82 (n)
  • 73.55 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
Species with no ortholog for VPREB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VPREB1 Gene

Gene Tree for VPREB1 (if available)
Gene Tree for VPREB1 (if available)

Paralogs for VPREB1 Gene

genes like me logo Genes that share paralogs with VPREB1: view

Variants for VPREB1 Gene

Sequence variations from dbSNP and Humsavar for VPREB1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1320 - 22,245,125(+) AATCA(A/G)ACAAG missense, reference
rs5750798 -- 22,242,880(+) GAGGG(C/G)TGGGC upstream-variant-2KB
rs5750799 -- 22,242,995(+) CAGGG(A/G)CTGCA upstream-variant-2KB
rs5757629 -- 22,243,190(+) TAGCA(A/G)TCACT upstream-variant-2KB
rs5757634 -- 22,243,795(+) AGTGG(C/T)GAGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VPREB1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv22e196 CNV Deletion 17116639
nsv526328 CNV Gain 19592680
nsv459421 CNV Gain 19166990
nsv817937 CNV Loss 17921354
dgv548n27 CNV Loss 19166990
nsv820089 CNV Gain 19587683
dgv728n67 CNV Loss 20364138
dgv37n64 CNV Loss 17921354
esv2670821 CNV Deletion 23128226
nsv469749 CNV Loss 16826518
nsv834147 CNV Loss 17160897
nsv459450 CNV Loss 19166990
esv2544553 CNV Deletion 19546169
nsv915139 CNV Loss 21882294
nsv817943 CNV Loss 17921354
esv2422480 CNV Deletion 17116639
nsv459451 CNV Loss 19166990
nsv433331 CNV Loss 18776910

Relevant External Links for VPREB1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPREB1 Gene

Disorders for VPREB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for VPREB1 Gene in MalaCards »

(2) Diseases for VPREB1 Gene including...

(1) University of Copenhagen DISEASES for VPREB1 Gene

(3) Novoseek inferred disease relationships for VPREB1 Gene

Disease -log(P) Hits PubMed IDs
common variable immunodeficiency 57.2 3
lymphoblastic leukemia acute 27 1
leukemia 24.3 2

Relevant External Links for VPREB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with VPREB1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for VPREB1 Gene

Publications for VPREB1 Gene

  1. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. (PMID: 7935499) Guelpa-Fonlupt V. … Schiff C. (Mol. Immunol. 1994) 3 4 23
  2. The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus. (PMID: 1903358) Mattei M.G. … Schiff C. (Genomics 1991) 3 23
  3. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. (PMID: 2117639) Tsubata T. … Reth M. (J. Exp. Med. 1990) 3 23
  4. Secretion of soluble pre-B cell receptors by pre-B cells. (PMID: 9058786) Bornemann K.D. … Corley R.B. (J. Immunol. 1997) 3 23
  5. Engineering and characterization of a single chain surrogate light chain variable domain. (PMID: 18287279) Morstadt L. … Baleja J.D. (Protein Sci. 2008) 4 23

Products for VPREB1 Gene

Sources for VPREB1 Gene

Back to Top