Aliases for VPREB1 Gene
External Ids for VPREB1 Gene
Previous GeneCards Identifiers for VPREB1 Gene
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for VPREB1 Gene
VPREB1 (V-Set Pre-B Cell Surrogate Light Chain 1) is a Protein Coding gene. Diseases associated with VPREB1 include Conidiobolomycosis and Mu Chain Disease. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is IGLV5-37.
UniProtKB/Swiss-Prot for VPREB1 Gene
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.