Aliases for VPREB1 Gene
External Ids for VPREB1 Gene
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for VPREB1 Gene
VPREB1 (Pre-B Lymphocyte 1) is a Protein Coding gene. Diseases associated with VPREB1 include conidiobolomycosis and common variable immunodeficiency. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLV4-60.
UniProtKB/Swiss-Prot for VPREB1 Gene
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation