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Aliases for VPREB1 Gene

Aliases for VPREB1 Gene

  • V-Set Pre-B Cell Surrogate Light Chain 1 2 3 5
  • CD179 Antigen-Like Family Member A 3 4
  • Pre-B Lymphocyte 1 2 3
  • V(Pre)B Protein 3 4
  • VPREB 3 4
  • Immunoglobulin Iota Chain 3
  • CD179a Antigen 4
  • Protein VPreB1 4
  • VpreB Protein 4
  • CD179a 3
  • IGVPB 3
  • IGI 3

External Ids for VPREB1 Gene

Previous GeneCards Identifiers for VPREB1 Gene

  • GC22P019297
  • GC22P020923
  • GC22P022600
  • GC22P005557

Summaries for VPREB1 Gene

Entrez Gene Summary for VPREB1 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for VPREB1 Gene

VPREB1 (V-Set Pre-B Cell Surrogate Light Chain 1) is a Protein Coding gene. Diseases associated with VPREB1 include Conidiobolomycosis and Mu Chain Disease. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is IGLV5-37.

UniProtKB/Swiss-Prot for VPREB1 Gene

  • Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

Gene Wiki entry for VPREB1 Gene

Additional gene information for VPREB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VPREB1 Gene

Genomics for VPREB1 Gene

Regulatory Elements for VPREB1 Gene

Enhancers for VPREB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H022195 1.3 ENCODE dbSUPER 12.6 -48.8 -48792 1 HDGF PKNOX1 ATF1 ARNT FEZF1 ZNF2 TCF12 GATA2 ZNF143 ATF7 IGLV5-52 TOP3B PPIL2 VPREB1 IGLV4-60 ENSG00000234630 CCDC116 IGLV8-61 IGLV6-57 IGLVI-56
GH22H022200 1.1 ENCODE dbSUPER 13.5 -43.1 -43089 1.3 HNRNPUL1 TBP RB1 TBL1XR1 BMI1 ZNF2 RAD21 ZNF143 ATF7 CEBPB TOP3B IGLV5-52 VPREB1 ENSG00000234630 PPIL2 TOP3BP1 IGLV11-55 IGLVI-56
GH22H022207 1 ENCODE dbSUPER 13 -36.7 -36659 0.2 CTCF RB1 TSC22D4 RAD21 CC2D1A CTBP1 GATA2 POLR2A EED SMC3 VPREB1 LOC100419915 IGLVIV-53
GH22H022206 1 ENCODE dbSUPER 13 -38.2 -38249 0.2 CTCF ETV1 ZSCAN4 NFXL1 CDC5L RAD21 MTA3 CTBP1 DIDO1 GATA2 VPREB1 TOP3B LOC100419915 IGLVIV-53
GH22H022209 0.8 ENCODE 13 -34.2 -34189 1.1 JUN MAX BATF FOSL1 FOS MAFK RNF2 L3MBTL2 NR4A1 JUNB IGLV10-54 VPREB1 IGLV1-41 IGLVIV-53 LOC100419915
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VPREB1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for VPREB1 Gene

Genomic Locations for VPREB1 Gene
841 bases
Plus strand

Genomic View for VPREB1 Gene

Genes around VPREB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VPREB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VPREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VPREB1 Gene

Proteins for VPREB1 Gene

  • Protein details for VPREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin iota chain
    Protein Accession:
    Secondary Accessions:
    • B5MCG2

    Protein attributes for VPREB1 Gene

    145 amino acids
    Molecular mass:
    16605 Da
    Quaternary structure:
    • Associates non-covalently with IGLL1.

    Three dimensional structures from OCA and Proteopedia for VPREB1 Gene

neXtProt entry for VPREB1 Gene

Post-translational modifications for VPREB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VPREB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VPREB1 Gene

Domains & Families for VPREB1 Gene

Gene Families for VPREB1 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Predicted secreted proteins

Protein Domains for VPREB1 Gene

Suggested Antigen Peptide Sequences for VPREB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with VPREB1: view

Function for VPREB1 Gene

Molecular function for VPREB1 Gene

GENATLAS Biochemistry:
immunoglobulin-like V gene,expressed in pre-B cells
UniProtKB/Swiss-Prot Function:
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

Phenotypes From GWAS Catalog for VPREB1 Gene

genes like me logo Genes that share phenotypes with VPREB1: view

Animal Models for VPREB1 Gene

MGI Knock Outs for VPREB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VPREB1 Gene

Localization for VPREB1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VPREB1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for VPREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with VPREB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for VPREB1 Gene

Pathways & Interactions for VPREB1 Gene

genes like me logo Genes that share pathways with VPREB1: view

Pathways by source for VPREB1 Gene

2 Reactome pathways for VPREB1 Gene

Interacting Proteins for VPREB1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)
Selected Interacting proteins: P12018-VPREB_HUMAN ENSP00000385361 for VPREB1 Gene via IID STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for VPREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with VPREB1: view

No data available for SIGNOR curated interactions for VPREB1 Gene

Drugs & Compounds for VPREB1 Gene

(1) Drugs for VPREB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with VPREB1: view

Transcripts for VPREB1 Gene

mRNA/cDNA for VPREB1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VPREB1 Gene

Pre-B lymphocyte 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VPREB1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -

Relevant External Links for VPREB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VPREB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VPREB1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VPREB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VPREB1 Gene:


SOURCE GeneReport for Unigene cluster for VPREB1 Gene:


mRNA Expression by UniProt/SwissProt for VPREB1 Gene:

Tissue specificity: Only expressed by pre-B-cells.

Evidence on tissue expression from TISSUES for VPREB1 Gene

  • Bone marrow(2.5)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with VPREB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VPREB1 Gene

Orthologs for VPREB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VPREB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VPREB1 33 34
  • 98.62 (n)
(Mus musculus)
Mammalia Vpreb2 33 16 34
  • 83.75 (n)
Vpreb1 34
  • 73 (a)
(Rattus norvegicus)
Mammalia Vpreb2 33
  • 81.82 (n)
(Canis familiaris)
Mammalia VPREB1 33 34
  • 80.44 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
Species where no ortholog for VPREB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VPREB1 Gene

Gene Tree for VPREB1 (if available)
Gene Tree for VPREB1 (if available)

Paralogs for VPREB1 Gene

genes like me logo Genes that share paralogs with VPREB1: view

Variants for VPREB1 Gene

Sequence variations from dbSNP and Humsavar for VPREB1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000474553 -- 22,243,662(+) CTTTA(A/T)GTCCA upstream-variant-2KB
rs1002247176 -- 22,245,781(+) GAGCC(A/G)GGTAA downstream-variant-500B
rs1003785685 -- 22,243,831(+) ACCTC(C/T)CAAGC upstream-variant-2KB
rs1004929482 -- 22,244,760(+) AGCCC(A/T)TGGGG upstream-variant-2KB
rs1005032993 -- 22,244,563(+) AGGGC(A/T)CTGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VPREB1 Gene

Variant ID Type Subtype PubMed ID
nsv834147 CNV loss 17160897
nsv820089 CNV gain 19587683
nsv817943 CNV loss 17921354
nsv817937 CNV loss 17921354
nsv7350 OTHER inversion 18451855
nsv588393 CNV loss 21841781
nsv588391 CNV loss 21841781
nsv588348 CNV gain 21841781
nsv526328 CNV gain 19592680
nsv469749 CNV loss 16826518
nsv459451 CNV loss 19166990
nsv459450 CNV loss 19166990
nsv459421 CNV gain 19166990
nsv433331 CNV loss 18776910
nsv1062771 CNV loss 25217958
nsv1058897 CNV loss 25217958
esv3893447 CNV gain 25118596
esv3647352 CNV gain 21293372
esv3647351 CNV loss 21293372
esv3647345 CNV loss 21293372
esv3647335 CNV loss 21293372
esv2670821 CNV deletion 23128226
esv2544553 CNV deletion 19546169
esv2422480 CNV deletion 17116639
dgv7998n54 CNV loss 21841781
dgv728n67 CNV loss 20364138
dgv548n27 CNV loss 19166990
dgv4504n100 CNV gain 25217958
dgv37n64 CNV loss 17921354
dgv22e196 CNV deletion 17116639

Variation tolerance for VPREB1 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VPREB1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VPREB1 Gene

Disorders for VPREB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for VPREB1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • infection by conidiobolus
mu chain disease
  • mu-chain disease
common variable immunodeficiency
  • acquired agammaglobulinemia
prediabetes syndrome
  • prediabetes
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for VPREB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with VPREB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VPREB1 Gene

Publications for VPREB1 Gene

  1. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. (PMID: 7935499) Guelpa-Fonlupt V … Schiff C (Molecular immunology 1994) 3 4 22 60
  2. Engineering and characterization of a single chain surrogate light chain variable domain. (PMID: 18287279) Morstadt L … Baleja JD (Protein science : a publication of the Protein Society 2008) 4 22 60
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  4. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 4 60
  5. Secretion of soluble pre-B cell receptors by pre-B cells. (PMID: 9058786) Bornemann KD … Corley RB (Journal of immunology (Baltimore, Md. : 1950) 1997) 3 22 60

Products for VPREB1 Gene

Sources for VPREB1 Gene

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