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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPREB1 Gene

protein-coding   GIFtS: 61
GCID: GC22P022600

Pre-B Lymphocyte 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pre-B Lymphocyte 11 2     IGVPB2
VPREB2 3 5     Immunoglobulin Iota Chain2
V(Pre)B Protein2 3     CD179a Antigen3
CD179 Antigen-Like Family Member A2 3     Protein VPreB13
IGI2 5     VpreB Protein3
CD179a2     

External Ids:    HGNC: 127091   Entrez Gene: 74412   Ensembl: ENSG000001695757   OMIM: 6051415   UniProtKB: P120183   

Export aliases for VPREB1 gene to outside databases

Previous GC identifers: GC22P019297 GC22P020923 GC22P005557


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VPREB1 Gene:
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the
early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide
chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of
pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell
differentiation. (provided by RefSeq, Oct 2008)

GeneCards Summary for VPREB1 Gene: 
VPREB1 (pre-B lymphocyte 1) is a protein-coding gene. Diseases associated with VPREB1 include conidiobolomycosis, and common variable immunodeficiency. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLV2-18.

UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018
Function: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of
pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell
differentiation

Gene Wiki entry for VPREB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPREB1 gene promoter:
         HOXA9   HOXA9B   STAT1   MIF-1   Meis-1b   RORalpha1   HEN1   FAC1   Zic3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPREB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VPREB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPREB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

VPREB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPREB1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022600:  view genomic region     (about GC identifiers)

Start:
22,599,087 bp from pter      End:
22,599,927 bp from pter
Size:
841 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018 (See protein sequence)
Recommended Name: Immunoglobulin iota chain precursor  
Size: 145 amino acids; 16605 Da
Subunit: Associates non-covalently with IGLL1
3 PDB 3D structures from and Proteopedia for VPREB1:
2H32 (3D)        2H3N (3D)        3BJ9 (3D)    
Secondary accessions: B5MCG2

Explore the universe of human proteins at neXtProt for VPREB1: NX_P12018

Explore proteomics data for VPREB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12018

  • VPREB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VPREB1 Protein Expression
    REFSEQ proteins: NP_009059.1  
    ENSEMBL proteins: 
     ENSP00000385361   ENSP00000304590  

    Human Recombinant Protein Products for VPREB1: 
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    Cloud-Clone Corp. Proteins for VPREB1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--

    VPREB1 for ontologies           About GeneDecksing



    VPREB1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry P12018

    ProtoNet protein and cluster: P12018

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    VPREB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPREB_HUMAN, P12018
    Function: Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of
    pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell
    differentiation

         Genatlas biochemistry entry for VPREB1:
    immunoglobulin-like V gene,expressed in pre-B cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding NAS--
    GO:0005515protein binding ----
         
    VPREB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VPREB1:
     Decreased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vpreb1):
     cellular  hematopoietic system  immune system 

    VPREB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for VPREB1: Vpreb1tm1Shim Vpreb1tm1Ilm

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPREB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for VPREB1 (P120182, 3 ENSP000003853614) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110863 I2D: score=3 STRING: ENSP00000361423
    LGALS1P093823, ENSP000002159094I2D: score=1 STRING: ENSP00000215909
    VPREB3Q9UKI33, ENSP000002489484I2D: score=1 STRING: ENSP00000248948
    IGHMP018713I2D: score=1 
    IGLL1ENSP000003293124STRING: ENSP00000329312
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS--

    VPREB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VPREB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPREB1 (VPREB)

    1 Novoseek inferred chemical compound relationship for VPREB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    probenecid 69.1 3 8833898 (1), 11187899 (1), 9232432 (1)

    Search CenterWatch for drugs/clinical trials and news about VPREB1 / VPREB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPREB1 gene: 
    NM_007128.2  

    Unigene Cluster for VPREB1:

    Pre-B lymphocyte 1
    Hs.247979  [show with all ESTs]
    Unigene Representative Sequence: BU180896
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403807(uc002zvx.1) ENST00000302273
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VPREB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VPREB1

    Additional mRNA sequence: 

    BC017922.1 CR456609.1 

    3 DOTS entries:

    DT.91716305  DT.120678050  DT.91716303 

    3 AceView cDNA sequences:

    NM_007128 CR456609 BC017922 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for VPREB1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:              -         
    SP2:                        


    ECgene alternative splicing isoforms for VPREB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPREB1 expression in normal human tissues (normalized intensities)      VPREB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAGGGTG
    VPREB1 Expression
    About this image


    VPREB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Bone Marrow CD105+ Cells   
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    See VPREB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPREB1

    SOURCE GeneReport for Unigene cluster: Hs.247979

    UniProtKB/Swiss-Prot: VPREB_HUMAN, P12018
    Tissue specificity: Only expressed by pre-B-cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VPREB1 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vpreb15 pre-B lymphocyte gene 1   --   16 (10.46 cM) 16868402 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    54(a)
    49(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343282.1(587154-587477)
    GL343282.1(578775-579364)


    ENSEMBL Gene Tree for VPREB1 (if available)
    TreeFam Gene Tree for VPREB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VPREB1 gene
    IGLV2-182  IGLV3-122  IGLV3-192  IGLV1-512  IGLV9-492  IGLV3-222  IGLV2-232  IGLV8-612  
    IGLV4-602  IGLV1-472  IGLV2-142  IGLV2-332  IGLV3-322  IGLV5-522  IGLV1-442  IGLV3-212  
    IGLV2-112  IGLV3-102  IGLV3-92  IGLV1-502  IGLV5-372  VPREB32  IGLV3-252  IGLV2-82  
    IGLV10-542  IGLV7-432  IGLV5-452  IGLV7-462  IGLV3-272  IGLV11-552  IGLV1-402  IGLV5-482  
    IGLV3-12  IGLV4-32  IGLV6-572  IGLV3-162  IGLV1-362  IGLV4-692  
    18/76 SIMAP similar genes for VPREB1 using alignment to 2 protein entries:     VPREB_HUMAN (see all proteins) (see all similar genes):
    IGLV4-3    IGLV5-37    IGLV5-45    IGLV11-55    V4-4    IGLV4-60
    V4-3    BV05S1J2.2    IGLV4-69    VLC8    BV05S1J2.1    IGLV1-40
    V5-2    V1-18    VKA17    V1    VL3L    IGKV1-5

    VPREB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/129 SNPs in VPREB1 are shown (see all 129)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115744541,2
    C,F--5555696(+) TGAAAC/GAAAGT 1 -- us2k16Minor allele frequency- G:0.09NA EA 418
    rs57507981,2
    C--5555731(+) GAGGGC/GTGGGC 1 -- us2k17Minor allele frequency- G:0.39NA WA EA 404
    rs791068621,2
    C,F--5555758(+) TATAAT/CTGTAA 1 -- us2k11Minor allele frequency- C:0.04EA 120
    rs60015511,2
    C,F,A--5555770(+) AGCAAA/GTAGAA 1 -- us2k111Minor allele frequency- G:0.29NA WA CSA EA 409
    rs1502658211,2
    --5555791(+) TCTCTC/GAGCTT 1 -- us2k10--------
    rs57507991,2
    C,F,A--5555846(+) CAGGGA/GCTGCA 1 -- us2k113Minor allele frequency- G:0.33NA WA CSA EA 414
    rs1922176191,2
    --5555964(+) ACACAC/TGAATG 1 -- us2k10--------
    rs115744551,2
    C,F,H--5555971(+) AATGAG/ACTACT 1 -- us2k15Minor allele frequency- A:0.00NA NS EA 454
    rs792264941,2
    F--5555996(+) ATGAAT/CGAATG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs115744561,2
    C,F--5556036(+) GGAGTT/CAGCAA 1 -- us2k12Minor allele frequency- C:0.10NA 160

    HapMap Linkage Disequilibrium report for VPREB1 (22599087 - 22599927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for VPREB1 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv22e196CNV Deletion17116639
    esv2422480CNV Deletion17116639
    esv2670821CNV Deletion23128226
    esv2544553CNV Deletion19546169
    nsv433331CNV Loss18776910
    dgv37n64CNV Loss17921354
    nsv834147CNV Loss17160897
    nsv817937CNV Loss17921354
    nsv469749CNV Loss16826518
    dgv548n27CNV Loss19166990


    Human Gene Mutation Database (HGMD): VPREB1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605141    OMIM disorders: --

    11 diseases for VPREB1:    About MalaCards
    conidiobolomycosis    common variable immunodeficiency    crouzon syndrome    agammaglobulinemia
    acute lymphoblastic leukemia    lymphoblastic leukemia    hepatitis b    rheumatoid arthritis
    arthritis    leukemia    hepatitis

    1 disease from the University of Copenhagen DISEASES database for VPREB1:
    Conidiobolomycosis

    VPREB1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for VPREB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    common variable immunodeficiency 57.2 3 8031574 (2), 7710759 (1)
    lymphoblastic leukemia acute 27 1 1884024 (1)
    leukemia 24.3 2 1884024 (2)

    Genetic Association Database (GAD): VPREB1
    Human Genome Epidemiology (HuGE) Navigator: VPREB1 (2 documents)

    Export disorders for VPREB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPREB1 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with VPREB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. (PubMed id 7935499)1, 2, 9 Guelpa-Fonlupt V....Schiff C. (1994)
    2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2 Kawasaki K....Shimizu N. (1997)
    4. The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments. (PubMed id 3139558)1, 3 Bauer S.R....Melchers F. (1988)
    5. Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species. (PubMed id 3258819)1, 2 Bauer S.R.... Melchers F. (1988)
    6. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. (PubMed id 2117639)1, 9 Tsubata T. and Reth M. (1990)
    7. Engineering and characterization of a single chain surrogate light chain variable domain. (PubMed id 18287279)2, 9 Morstadt L....Baleja J.D. (2008)
    8. Secretion of soluble pre-B cell receptors by pre-B cells. (PubMed id 9058786)1, 9 Bornemann K.D....Corley R.B. (1997)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. The potential role of VPREB1 gene copy number variati on in susceptibility to rheumatoid arthritis. (PubMed id 21144590)1 Yim S.H....Chung H.T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7441 HGNC: 12709 AceView: VPREB1 Ensembl:ENSG00000169575 euGenes: HUgn7441
    ECgene: VPREB1 H-InvDB: VPREB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPREB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VPREB1 Genetics and Cytogenetics in Oncology and Haematology
    IMGT entry for VPREB The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    Wikipedia http://en.wikipedia.org/wiki/VPREB1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPREB1 gene:
    Search GeneIP for patents involving VPREB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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