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VPRBP Gene

protein-coding   GIFtS: 51
GCID: GC03M051433

Vpr (HIV-1) Binding Protein

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vpr (HIV-1) Binding Protein1 2     Protein VPRBP2
DDB1 And CUL4 Associated Factor 11 2     Vpr-Binding Protein2
Serine/Threonine-Protein Kinase VPRBP2 3     EC 2.7.11.13
Vpr-Interacting Protein2 3     KIAA08003
DCAF12 3     RIP3
DDB1- And CUL4-Associated Factor 12 3     VprBP3
HIV-1 Vpr-Binding Protein2 3     

External Ids:    HGNC: 309111   Entrez Gene: 97302   Ensembl: ENSG000001450417   UniProtKB: Q9Y4B63   

Export aliases for VPRBP gene to outside databases

Previous GC identifer: GC03M051409


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for VPRBP Gene:
VPRBP (Vpr (HIV-1) binding protein) is a protein-coding gene. Diseases associated with VPRBP include neurilemmoma, and hiv-1.

UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6
Function: Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an
atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase
regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3
ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and
proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins:
recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by
the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in
B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair
during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of
proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an
atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A
(H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory
region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number
of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its
interaction with LLGL1 and LLGL2 (PubMed:20644714). In case of infection by HIV-1 virus, it is recruited by HIV-1
Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and
also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr
protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins
such as TERT and ZIP/ZGPAT. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack
the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of
the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage

Gene Wiki entry for VPRBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the VPRBP gene promoter:
         AhR   STAT1   Pax-5   NCX/Ncx   AP-4   AP-2gamma   Roaz   Arnt   Gfi-1   NRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPRBP promoter sequence
   Search Chromatin IP Primers for VPRBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VPRBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.2

VPRBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPRBP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M051433:  view genomic region     (about GC identifiers)

Start:
51,433,298 bp from pter      End:
51,534,018 bp from pter
Size:
100,721 bases      Orientation:
minus strand

1 alternative location:
Chr3-,NW_003315910 17,190-121,325     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6 (See protein sequence)
Recommended Name: Protein VPRBP  
Size: 1507 amino acids; 169007 Da
Subunit: Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named
CUL4A-RBX1-DDB1-DCAF1/VPRBP complex. Interacts with DDB1; the interaction is direct. Also forms a ternary complex
with DDA1 and DDB1. Interacts with NF2 (via FERM domain). Component of the EDVP complex, a E3 ligase complex
containing DYRK2, EDD/UBR5, DDB1 and VPRBP. Interacts with DYRK2; the interaction is direct. Interacts with RAG1;
the interaction is direct. Interacts with LLGL1 and LLGL2. Interacts with histone H3. Interact with HIV-1 virus
Vpr protein and HIV-2 virus Vpx protein; the interaction is direct
Sequence caution: Sequence=BAA34520.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for VPRBP:
4CC9 (3D)    
Secondary accessions: Q2YD74 Q8TBD9 Q9HCA1 Q9UG37
Alternative splicing: 3 isoforms:  Q9Y4B6-1   Q9Y4B6-2   Q9Y4B6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPRBP: NX_Q9Y4B6

Explore proteomics data for VPRBP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys280, Lys1224
  • Modification sites at PhosphoSitePlus

  • See VPRBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001165375.1  NP_055518.1  

    ENSEMBL proteins: 
     ENSP00000393183   ENSP00000421724   ENSP00000338857  
    Reactome Protein details: Q9Y4B6

    VPRBP Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR006594 LisH_dimerisation
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y4B6

    ProtoNet protein and cluster: Q9Y4B6

    1 Blocks protein domain: IPB006594 Lissencephaly type-1-like homology motif

    UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6
    Domain: The protein kinase-like region mediates the threonine-protein kinase activity (PubMed:24140421)
    Domain: The DWD boxes are required for interaction with DDB1
    Domain: The chromo domain with a restricted pocket directly recognizes monomethylated substrates (PubMed:23063525)
    Similarity: Belongs to the VPRBP/DCAF1 family
    Similarity: Contains 1 chromo domain
    Similarity: Contains 1 LisH domain
    Similarity: Contains 5 WD repeats


    VPRBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPRBP_HUMAN, Q9Y4B6
    Function: Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an
    atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase
    regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3
    ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and
    proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins:
    recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by
    the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in
    B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair
    during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of
    proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an
    atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A
    (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory
    region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number
    of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its
    interaction with LLGL1 and LLGL2 (PubMed:20644714). In case of infection by HIV-1 virus, it is recruited by HIV-1
    Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and
    also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr
    protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins
    such as TERT and ZIP/ZGPAT. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack
    the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of
    the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Up-regulated in a number of cancer cell lines (at protein level)

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI19264781
    GO:0005524ATP binding IEA--
    GO:1990244histone kinase activity (H2A-T120 specific) IDA--
         
    VPRBP for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for VPRBP:
     Decreased cell number  Decreased homologous recombina  Decreased p24 protein expressi  Decreased viability of wild-ty 
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Vprbp):
     cellular  mortality/aging 

    VPRBP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vprbptm1.2Yxi for VPRBP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VPRBP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VPRBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VPRBP

    miRNA
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    miRTarBase miRNAs that target VPRBP:
    hsa-mir-17-5p (MIRT050949), hsa-mir-484 (MIRT042061)

    Block miRNA regulation of human, mouse, rat VPRBP using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate VPRBP:
    hsa-miR-942 hsa-miR-214 hsa-miR-769-5p hsa-miR-1236 hsa-miR-216b hsa-miR-761 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidVPRBP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VPRBP

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    GenScript: all cDNA clones in your preferred vector (see all 2): VPRBP (NM_014703)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPRBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VPRBP_HUMAN, Q9Y4B6: Cytoplasm. Nucleus. Note=Associated with chromatin in a DDB1-independent and cell
    cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before
    mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0008180colocalizes with COP9 signalosome IDA18850735

    VPRBP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VPRBP About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for VPRBP
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6
    Pathway: Protein modification; protein ubiquitination


    VPRBP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VPRBP
    Interactions:

        GeneGlobe Interaction Network for VPRBP

    Selected Interacting proteins for VPRBP (Q9Y4B61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB1Q165311, 2, 3EBI-1996353,EBI-350322 MINT-8384568 MINT-8384485 MINT-8384433 I2D: score=1 
    CUL4AQ136192, 3MINT-8384433 I2D: score=1 
    RBX1P628772, 3MINT-8384433 I2D: score=1 
    DDA1Q9BW613I2D: score=3 
    COPS5Q929053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0016032viral process IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    VPRBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VPRBP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VPRBP gene (2 alternative transcripts): 
    NM_001171904.1  NM_014703.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423656(uc003dbe.2 uc021wys.1) ENST00000504652(uc003dbg.2)
    ENST00000335891(uc003dbf.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-942 hsa-miR-214 hsa-miR-769-5p hsa-miR-1236 hsa-miR-216b hsa-miR-761 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidVPRBP 3' UTR sequence
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    Selected AceView cDNA sequences (see all 171):

    AL703924 BU686589 CD251538 BC022792 BQ016608 AA152298 AI620544 BE897065 
    BU502622 AI537219 AI634416 BE271872 BM755792 BU543945 AA478388 AI521848 
    AL039782 AW173517 AA778168 BQ063203 BG230639 AA714851 BQ424531 BQ027340 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VPRBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCATTGTGG
    VPRBP Expression
    About this image

    VPRBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VPRBP Protein Expression

    UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VPRBP gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vprbp1 , 5 Vpr (HIV-1) binding protein1, 5 91.97(n)1
    98.28(a)1
      9 (57.98 cM)5
    3210061  NM_001015507.21  NP_001015507.11 
     1068218745 
    chicken
    (Gallus gallus)
    Aves VPRBP1 Vpr (HIV-1) binding protein 81.95(n)
    93.54(a)
      415921  XM_004944403.1  XP_004944460.1 
    lizard
    (Anolis carolinensis)
    Reptilia VPRBP6
    Vpr (HIV-1) binding protein
    67(a)
    1 ↔ 1
    2(152102138-152167394)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ085853.12   -- 77.32(n)    BJ085853.1 
    zebrafish
    (Danio rerio)
    Actinopterygii VPRBP6
    Vpr (HIV-1) binding protein
    81(a)
    1 ↔ 1
    Zv9_NA90(100-9559) ENSDARG00000087418
    fruit fly
    (Drosophila melanogaster)
    Insecta mahj1 mahjong 48.86(n)
    42.42(a)
      37462  NM_001259522.1  NP_001246451.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dcaf-11 dcaf-1 46.98(n)
    37.74(a)
      177804  NM_069324.5  NP_501725.2 


    ENSEMBL Gene Tree for VPRBP (if available)
    TreeFam Gene Tree for VPRBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VPRBP (see all 953)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443269711,2
    C--51402829(+) GAGTT-/CCTAGG 2 -- int10--------
    rs346439011,2
    C--51435893(+) TATTGT/GGAAAT 2 -- int11Minor allele frequency- G:0.00NA 2
    rs170517821,2
    C,F,H--51436456(+) CTCCCG/AGAGAC 2 -- int111Minor allele frequency- A:0.20NA NS EA 802
    rs768408001,2
    C,F--51436922(+) GTGACG/ACCCTG 2 -- int11Minor allele frequency- A:0.02WA 118
    rs340812991,2
    C--51437118(+) TACCT-/AAGCTT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs3767499551,2
    C--51437119(+) GTACC-/AGCTTG 2 -- int10--------
    rs170517831,2
    C,F,H--51437218(+) TTTTAC/ACTAGG 2 -- int112Minor allele frequency- A:0.19NA NS EA WA CSA 796
    rs46877311,2
    C,F,A,H--51437296(+) GCCCCA/GTGTGG 2 -- int17Minor allele frequency- G:0.19NS EA WA 654
    rs37924081,2
    C,F,H--51437597(+) GGTGAA/GGAGTA 2 -- int119Minor allele frequency- G:0.21EA NS NA WA CSA 3714
    rs105755941,2
    C--51438563(+) atctc-/A/AA  
            
    aaaaa
    2 -- int10--------

    HapMap Linkage Disequilibrium report for VPRBP (51433298 - 51534018 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for VPRBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2646677CNV Deletion19546169
    nsv3816CNV Insertion18451855
    esv992244CNV Insertion20482838
    esv1010319CNV Insertion20482838
    nsv508920CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VPRBP
    DNA2.0 Custom Variant and Variant Library Synthesis for VPRBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for VPRBP:    
    About MalaCards
    neurilemmoma    hiv-1    lissencephaly    neurofibromatosis
    brain cancer    endotheliitis    malaria


    VPRBP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): VPRBP
    Human Genome Epidemiology (HuGE) Navigator: VPRBP (1 document)

    Export disorders for VPRBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VPRBP gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with VPRBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein- protein interaction with a novel human cytoplasmic protein VprBP. (PubMed id 11223251)1, 2, 3, 9 Zhang S.... Zhao L.-J. (Gene 2001)
    2. Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein. (PubMed id 8195203)1, 2, 3 Zhao L.-J.... Narayan O. (J. Biol. Chem. 1994)
    3. Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. (PubMed id 18606781)1, 2, 9 McCall C.M.... Xiong Y. (Mol. Cell. Biol. 2008)
    4. Structural basis of lentiviral subversion of a cellular protein degradation pathway. (PubMed id 24336198)1, 2 Schwefel D.... Taylor I.A. (Nature 2014)
    5. VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. (PubMed id 24140421)1, 2 Kim K.... An W. (Mol. Cell 2013)
    6. Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. (PubMed id 23362280)1, 2 Jung H.Y....Park J.I. (J. Biol. Chem. 2013)
    7. HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP. (PubMed id 24116224)1, 2 Maudet C.... Margottin-Goguet F. (PLoS ONE 2013)
    8. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. (PubMed id 23063525)1, 2 Lee J.M....Baek S.H. (Mol. Cell 2012)
    9. Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. (PubMed id 22184063)1, 2 Kim K....An W. (Mol. Cell. Biol. 2012)
    10. Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx. (PubMed id 19923175)1, 2 Gramberg T.... Landau N.R. (J. Virol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9730 HGNC: 30911 AceView: VprBP Ensembl:ENSG00000145041 euGenes: HUgn9730
    ECgene: VPRBP H-InvDB: VPRBP

    (According to HUGE)
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    HUGE: KIAA0800

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VPRBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VPRBP gene:
    Search GeneIP for patents involving VPRBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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