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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VPRBP Gene

protein-coding   GIFtS: 53
GCID: GC03M051433

Vpr (HIV-1) Binding Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vpr (HIV-1) Binding Protein1 2     Protein VPRBP2
DDB1 And CUL4 Associated Factor 11 2     Vpr-Binding Protein2
Vpr-Interacting Protein2 3     KIAA08003
DCAF12 3     RIP3
DDB1- And CUL4-Associated Factor 12 3     VprBP3
HIV-1 Vpr-Binding Protein2 3     

External Ids:    HGNC: 309111   Entrez Gene: 97302   Ensembl: ENSG000001450417   UniProtKB: Q9Y4B63   

Export aliases for VPRBP gene to outside databases

Previous GC identifer: GC03M051409


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for VPRBP Gene: 
VPRBP (Vpr (HIV-1) binding protein) is a protein-coding gene. Diseases associated with VPRBP include neurilemmoma, and lissencephaly, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6
Function: Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, VprBP/DCAF1 may
function as the substrate recognition module within this complex. For example, VprBP/DCAF1 targets NF2 to the E3
ubiquitin-ligase complex for ubiquitination and subsequent proteasome-dependent degradation. In case of infection
by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1 function leading to arrest
the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3
ubiquitin ligase. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the
CUL4A-RBX1-DDB1 function leading to enhanced efficiency of macrophage infection and promotion of the replication
of cognate primate lentiviruses in cells of monocyte/macrophage lineage. Associated with chromatin in a
DDB1-independent and cell cycle-dependent manner, VprBP/DCAF1 is recruited to chromatin as DNA is being
replicated and is released from chromatin before mitosis

Gene Wiki entry for VPRBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPRBP gene promoter:
         AhR   STAT1   Pax-5   NCX/Ncx   AP-4   AP-2gamma   Roaz   Arnt   Gfi-1   NRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVPRBP promoter sequence
   Search SABiosciences Chromatin IP Primers for VPRBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VPRBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.2

VPRBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPRBP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M051433:  view genomic region     (about GC identifiers)

Start:
51,433,298 bp from pter      End:
51,534,018 bp from pter
Size:
100,721 bases      Orientation:
minus strand

1 alternative location:
Chr3-,NW_003315910 17,190-121,325     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6 (See protein sequence)
Recommended Name: Protein VPRBP  
Size: 1507 amino acids; 169007 Da
Subunit: Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex that could interact with
HIV-1 virus Vpr protein and HIV-2 virus Vpx protein. Interacts directly with DDB1. Also forms a ternary complex
with DDA1 and DDB1. Interacts with NF2 (via FERM domain). Component of EDD/UBR5-DDB1-VprBP/DCAF1 E3
ubiquitin-protein ligase complex. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and
VPRBP proteins (EDVP complex). Interacts directly with DYRK2
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=BAA34520.2; Type=Erroneous initiation;
Secondary accessions: Q2YD74 Q8TBD9 Q9HCA1 Q9UG37
Alternative splicing: 3 isoforms:  Q9Y4B6-1   Q9Y4B6-2   Q9Y4B6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VPRBP: NX_Q9Y4B6

Explore proteomics data for VPRBP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4B6

  • VPRBP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VPRBP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001165375.1  NP_055518.1  

    ENSEMBL proteins: 
     ENSP00000393183   ENSP00000421724   ENSP00000338857  
    Reactome Protein details: Q9Y4B6
    Human Recombinant Protein Products for VPRBP: 
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    Cloud-Clone Corp. Proteins for VPRBP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0008180colocalizes with COP9 signalosome IDA18850735

    VPRBP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DCAF: DDB1 and CUL4 associated factors

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR016024 ARM-type_fold
     IPR006594 LisH_dimerisation

    Graphical View of Domain Structure for InterPro Entry Q9Y4B6

    ProtoNet protein and cluster: Q9Y4B6

    1 Blocks protein domain: IPB006594 Lissencephaly type-1-like homology motif

    UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6
    Domain: The DWD boxes are required for interaction with DDB1
    Similarity: Belongs to the VPRBP/DCAF1 family
    Similarity: Contains 1 LisH domain
    Similarity: Contains 5 WD repeats


    VPRBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VPRBP_HUMAN, Q9Y4B6
    Function: Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, VprBP/DCAF1 may
    function as the substrate recognition module within this complex. For example, VprBP/DCAF1 targets NF2 to the E3
    ubiquitin-ligase complex for ubiquitination and subsequent proteasome-dependent degradation. In case of infection
    by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1 function leading to arrest
    the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3
    ubiquitin ligase. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the
    CUL4A-RBX1-DDB1 function leading to enhanced efficiency of macrophage infection and promotion of the replication
    of cognate primate lentiviruses in cells of monocyte/macrophage lineage. Associated with chromatin in a
    DDB1-independent and cell cycle-dependent manner, VprBP/DCAF1 is recruited to chromatin as DNA is being
    replicated and is released from chromatin before mitosis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI19264781
         
    VPRBP for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for VPRBP:
     Decreased cell number  Decreased homologous recombina  Decreased p24 protein expressi  Decreased viability of wild-ty 
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Vprbp):
     cellular  mortality/aging 

    VPRBP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vprbptm1.2Yxi for VPRBP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VPRBP 
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    hsa-miR-942 hsa-miR-214 hsa-miR-769-5p hsa-miR-1236 hsa-miR-216b hsa-miR-761 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidVPRBP 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VPRBP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VPRBP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for VPRBP
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6
    Pathway: Protein modification; protein ubiquitination


    VPRBP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPRBP

    5/20 Interacting proteins for VPRBP (Q9Y4B61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB1Q165312, 3MINT-8384568 MINT-8384485 MINT-8384433 I2D: score=1 
    CUL4AQ136192, 3MINT-8384433 I2D: score=1 
    RBX1P628772, 3MINT-8384433 I2D: score=1 
    DDA1Q9BW613I2D: score=3 
    COPS5Q929053I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0019048modulation by virus of host morphology or physiology IEA--

    VPRBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPRBP

    Search CenterWatch for drugs/clinical trials and news about VPRBP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VPRBP gene (2 alternative transcripts): 
    NM_001171904.1  NM_014703.2  

    Unigene Cluster for VPRBP:

    Vpr (HIV-1) binding protein
    Hs.716623  [show with all ESTs]
    Unigene Representative Sequence: NM_014703
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423656(uc003dbe.2 uc021wys.1) ENST00000504652(uc003dbg.2)
    ENST00000335891(uc003dbf.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate VPRBP:
    hsa-miR-942 hsa-miR-214 hsa-miR-769-5p hsa-miR-1236 hsa-miR-216b hsa-miR-761 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidVPRBP 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional mRNA sequence: 

    AB018343.1 AF061935.1 AF086402.1 AK023239.1 AL080145.1 BC022792.1 BC110371.1 

    11 DOTS entries:

    DT.95199367  DT.91768433  DT.97846028  DT.415892  DT.102845427  DT.100796651  DT.100796652  DT.120920384 
    DT.120920416  DT.95180335  DT.95194572 

    24/171 AceView cDNA sequences (see all 171):

    CD674532 BU155628 AI657159 AI537219 AA778168 AA478388 BQ016608 BQ424531 
    BG230639 BE271872 AF086402 AL039782 AI620544 BQ957476 AI634416 AA149266 
    BU543945 AA714851 BU502622 AA152298 BU686589 BM755792 BQ063203 BQ027340 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VPRBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCATTGTGG
    VPRBP Expression
    About this image


    See VPRBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VPRBP

    SOURCE GeneReport for Unigene cluster: Hs.716623

    UniProtKB/Swiss-Prot: VPRBP_HUMAN, Q9Y4B6
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VPRBP gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vprbp1 , 5 Vpr (HIV-1) binding protein1, 5 91.98(n)1
    98.22(a)1
      9 (57.98 cM)5
    3210061  NM_001015507.21  NP_001015507.11 
     1068218745 
    chicken
    (Gallus gallus)
    Aves VPRBP1 Vpr (HIV-1) binding protein 82.2(n)
    94.1(a)
      415921  XM_414265.3  XP_414265.3 
    lizard
    (Anolis carolinensis)
    Reptilia VPRBP6
    Uncharacterized protein
    66(a)
    1 ↔ 1
    2(152102138-152167394)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ085853.12   -- 77.32(n)    BJ085853.1 
    zebrafish
    (Danio rerio)
    Actinopterygii VPRBP (2 of 2)6
    VPRBP (1 of 2)6
    Vpr (HIV-1) binding protein

    80(a)
    many → 1
    many → 1
    Zv9_NA928(42568-48171)
    Zv9_NA90(100-9559)
    fruit fly
    (Drosophila melanogaster)
    Insecta mahj1 mahjong 48.52(n)
    41.48(a)
      37462  NM_137748.3  NP_611592.2 
    worm
    (Caenorhabditis elegans)
    Secernentea dcaf-11 Protein DCAF-1 46.38(n)
    36.4(a)
      177804  NM_069324.4  NP_501725.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DCAF11 DDB1- and CUL4-associated factor-1 45.6(n)
    35.93(a)
      829244  NM_119266.6  NP_194845.4 


    ENSEMBL Gene Tree for VPRBP (if available)
    TreeFam Gene Tree for VPRBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/953 SNPs in VPRBP are shown (see all 953)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443269711,2
    C--51402829(+) GAGTT-/CCTAGG 2 -- int10--------
    rs346439011,2
    C--51435893(+) TATTGT/GGAAAT 2 -- int11Minor allele frequency- G:0.00NA 2
    rs170517821,2
    C,F,H--51436456(+) CTCCCG/AGAGAC 2 -- int111Minor allele frequency- A:0.20NA NS EA 802
    rs768408001,2
    C,F--51436922(+) GTGACG/ACCCTG 2 -- int11Minor allele frequency- A:0.02WA 118
    rs340812991,2
    C--51437118(+) TACCT-/AAGCTT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs3767499551,2
    C--51437119(+) GTACC-/AGCTTG 2 -- int10--------
    rs170517831,2
    C,F,H--51437218(+) TTTTAC/ACTAGG 2 -- int112Minor allele frequency- A:0.19NA NS EA WA CSA 796
    rs46877311,2
    C,F,A,H--51437296(+) GCCCCA/GTGTGG 2 -- int17Minor allele frequency- G:0.19NS EA WA 654
    rs37924081,2
    C,F,H--51437597(+) GGTGAA/GGAGTA 2 -- int119Minor allele frequency- G:0.21EA NS NA WA CSA 3714
    rs105755941,2
    C--51438563(+) atctc-/A/AA  
            
    aaaaa
    2 -- int10--------

    HapMap Linkage Disequilibrium report for VPRBP (51433298 - 51534018 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for VPRBP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2646677CNV Deletion19546169
    nsv3816CNV Insertion18451855
    esv992244CNV Insertion20482838
    esv1010319CNV Insertion20482838
    nsv508920CNV Insertion20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for VPRBP:    About MalaCards
    neurilemmoma    lissencephaly    neurofibromatosis    endotheliitis


    VPRBP for disorders           About GeneDecksing

    Genetic Association Database (GAD): VPRBP
    Human Genome Epidemiology (HuGE) Navigator: VPRBP (1 document)

    Export disorders for VPRBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VPRBP gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with VPRBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP. (PubMed id 11223251)1, 2, 3, 9 Zhang S....Zhao L.J. (2001)
    2. Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein. (PubMed id 8195203)1, 2, 3 Zhao L.-J.... Narayan O. (1994)
    3. Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. (PubMed id 18606781)1, 2, 9 McCall C.M.... Xiong Y. (2008)
    4. Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx. (PubMed id 19923175)1, 2 Gramberg T.... Landau N.R. (2010)
    5. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. (PubMed id 20178741)1, 2 Li W....Giancotti F.G. (2010)
    6. Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions. (PubMed id 19838296)1, 2 Jacquot G.... Benichou S. (2009)
    7. The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A- DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection. (PubMed id 19264781)1, 2 Bergamaschi A.... Transy C. (2009)
    8. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. (PubMed id 19287380)1, 2 Maddika S. and Chen J. (2009)
    9. Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. (PubMed id 18464893)1, 2 Srivastava S....Skowronski J. (2008)
    10. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. (PubMed id 18332868)1, 2 Huang J. and Chen J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9730 HGNC: 30911 AceView: VprBP Ensembl:ENSG00000145041 euGenes: HUgn9730
    ECgene: VPRBP H-InvDB: VPRBP

    (According to HUGE)
    About This Section
    HUGE: KIAA0800

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VPRBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VPRBP gene:
    Search GeneIP for patents involving VPRBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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