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Aliases for VOPP1 Gene

Aliases for VOPP1 Gene

  • Vesicular, Overexpressed In Cancer, Prosurvival Protein 1 2 3
  • EGFR-Coamplified And Overexpressed Protein 2 3 4
  • Glioblastoma-Amplified Secreted Protein 2 3 4
  • ECOP 3 4 6
  • GASP 3 4 6
  • Putative NF-Kappa-B-Activating Protein 055N 3 4
  • Hypothetical Protein DKFZp564K0822 3

External Ids for VOPP1 Gene

Summaries for VOPP1 Gene

GeneCards Summary for VOPP1 Gene

VOPP1 (Vesicular, Overexpressed In Cancer, Prosurvival Protein 1) is a Protein Coding gene. Diseases associated with VOPP1 include glioblastoma. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for VOPP1 Gene

  • Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.

Gene Wiki entry for VOPP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VOPP1 Gene

Genomics for VOPP1 Gene

Genomic Location for VOPP1 Gene

Start:
55,436,056 bp from pter
End:
55,572,988 bp from pter
Size:
136,933 bases
Orientation:
Minus strand

Genomic View for VOPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VOPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VOPP1 Gene

No data available for Regulatory Elements for VOPP1 Gene

Proteins for VOPP1 Gene

  • Protein details for VOPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AW1-VOPP1_HUMAN
    Recommended name:
    Vesicular, overexpressed in cancer, prosurvival protein 1
    Protein Accession:
    Q96AW1
    Secondary Accessions:
    • B0AZU1
    • B2RAT4
    • B3KS72
    • C9JWR3
    • Q6FIE3
    • Q8NBN8
    • Q96RE5
    • Q9H0W4

    Protein attributes for VOPP1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK82888.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for VOPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VOPP1 Gene

Proteomics data for VOPP1 Gene at MOPED

Post-translational modifications for VOPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VOPP1 Gene

Domains for VOPP1 Gene

Protein Domains for VOPP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

VOPP1_HUMAN
Family:
  • Belongs to the VOPP1/ECOP family.:
    • Q96AW1
genes like me logo Genes that share domains with VOPP1: view

No data available for Gene Families for VOPP1 Gene

Function for VOPP1 Gene

Molecular function for VOPP1 Gene

UniProtKB/Swiss-Prot Function: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.

Gene Ontology (GO) - Molecular Function for VOPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with VOPP1: view

Phenotypes for VOPP1 Gene

GenomeRNAi human phenotypes for VOPP1:
genes like me logo Genes that share phenotypes with VOPP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VOPP1 Gene

Localization for VOPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VOPP1 Gene

Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VOPP1 Gene COMPARTMENTS Subcellular localization image for VOPP1 gene
Compartment Confidence
endosome 4
extracellular 3
plasma membrane 3
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VOPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA --
GO:0030659 cytoplasmic vesicle membrane IDA 20571887
GO:0031301 integral component of organelle membrane IDA 20571887
genes like me logo Genes that share ontologies with VOPP1: view

Pathways for VOPP1 Gene

SuperPathways for VOPP1 Gene

No Data Available

Interacting Proteins for VOPP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000285279%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000285279 Q96AW1-VOPP1_HUMAN for VOPP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for VOPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IMP 12761501
genes like me logo Genes that share ontologies with VOPP1: view

No data available for Pathways by source for VOPP1 Gene

Transcripts for VOPP1 Gene

Unigene Clusters for VOPP1 Gene

Vesicular, overexpressed in cancer, prosurvival protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VOPP1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - -
SP13: - - - -
SP14: - - -

ExUns: 17b · 17c · 17d · 17e · 17f · 17g · 17h · 17i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for VOPP1 Gene

GeneLoc Exon Structure for
VOPP1
ECgene alternative splicing isoforms for
VOPP1

Expression for VOPP1 Gene

mRNA expression in normal human tissues for VOPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VOPP1 Gene

SOURCE GeneReport for Unigene cluster for VOPP1 Gene Hs.488307

mRNA Expression by UniProt/SwissProt for VOPP1 Gene

Q96AW1-VOPP1_HUMAN
Tissue specificity: Widely expressed with highest levels in thymus and ovary.
genes like me logo Genes that share expressions with VOPP1: view

Orthologs for VOPP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VOPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VOPP1 36
  • 99.81 (n)
  • 100 (a)
VOPP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VOPP1 36
  • 87.15 (n)
  • 88.55 (a)
VOPP1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VOPP1 36
  • 84.92 (n)
  • 86.9 (a)
VOPP1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vopp1 36
  • 84.11 (n)
  • 89.53 (a)
Vopp1 16
Vopp1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VOPP1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VOPP1 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vopp1 36
  • 83.91 (n)
  • 89.53 (a)
chicken
(Gallus gallus)
Aves VOPP1 36
  • 74.55 (n)
  • 86.67 (a)
VOPP1 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19741 36
tropical clawed frog
(Silurana tropicalis)
Amphibia vopp1 36
  • 71.81 (n)
  • 82.55 (a)
zebrafish
(Danio rerio)
Actinopterygii vopp1 36
  • 65.38 (n)
  • 63.87 (a)
vopp1 37
  • 55 (a)
OneToMany
VOPP1 (1 of 2) 37
  • 43 (a)
OneToMany
Species with no ortholog for VOPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VOPP1 Gene

ENSEMBL:
Gene Tree for VOPP1 (if available)
TreeFam:
Gene Tree for VOPP1 (if available)

Paralogs for VOPP1 Gene

No data available for Paralogs for VOPP1 Gene

Variants for VOPP1 Gene

Sequence variations from dbSNP and Humsavar for VOPP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6620 -- 55,470,847(-) CACTT(C/T)GGTGA utr-variant-3-prime
rs712818 -- 55,477,202(+) AGGCA(C/T)GTCCA intron-variant
rs712819 -- 55,473,098(+) ACACC(C/G)CAAGT intron-variant
rs815934 -- 55,506,323(+) ATTAC(A/G)CAAAA intron-variant
rs815935 -- 55,507,838(+) TCCCA(C/T)GGCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VOPP1 Gene

Variant ID Type Subtype PubMed ID
esv2734425 CNV Deletion 23290073
esv997261 CNV Deletion 20482838
esv28230 CNV Gain+Loss 19812545
nsv469822 CNV Complex 16826518

Relevant External Links for VOPP1 Gene

HapMap Linkage Disequilibrium report
VOPP1

Disorders for VOPP1 Gene

(1) MalaCards Diseases for VOPP1 Gene

Search for VOPP1 Gene in MalaCards »

Relevant External Links for VOPP1

Human Genome Epidemiology (HuGE) Navigator
VOPP1
genes like me logo Genes that share disorders with VOPP1: view

No data available for UniProtKB/Swiss-Prot for VOPP1 Gene

Publications for VOPP1 Gene

  1. ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner. (PMID: 15735698) Park S. … James C.D. (Oncogene 2005) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for VOPP1 Gene

Sources for VOPP1 Gene

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