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Aliases for VOPP1 Gene

Aliases for VOPP1 Gene

  • Vesicular, Overexpressed In Cancer, Prosurvival Protein 1 2 3 5
  • EGFR-Coamplified And Overexpressed Protein 2 3 4
  • Glioblastoma-Amplified Secreted Protein 2 3 4
  • Putative NF-Kappa-B-Activating Protein 055N 3 4
  • GASP 3 4
  • ECOP 3 4
  • Hypothetical Protein DKFZp564K0822 3

External Ids for VOPP1 Gene

Previous GeneCards Identifiers for VOPP1 Gene

  • GC07M055503

Summaries for VOPP1 Gene

GeneCards Summary for VOPP1 Gene

VOPP1 (Vesicular, Overexpressed In Cancer, Prosurvival Protein 1) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for VOPP1 Gene

  • Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.

Gene Wiki entry for VOPP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VOPP1 Gene

Genomics for VOPP1 Gene

Regulatory Elements for VOPP1 Gene

Enhancers for VOPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G055545 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27.5 +20.5 20478 15.6 HDGF PKNOX1 WRNIP1 SIN3A ZBTB7B YY1 TCF12 FOS JUNB TBX21 VOPP1 ENSG00000223475 LOC100129276 GC07P055550 PIR50019
GH07G055531 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +38.1 38109 7.4 HDGF PKNOX1 WRNIP1 SIN3A ELK1 ZNF143 ZNF207 FOS JUNB TBX21 VOPP1 GC07P055550 GC07P055491
GH07G055567 1.7 FANTOM5 ENCODE dbSUPER 13.6 +2.0 1977 8.0 HDGF PKNOX1 AGO1 WRNIP1 SIN3A ARID4B DMAP1 ZNF766 CBX5 ZNF207 VOPP1 SEC61G ENSG00000223475 PIR61140
GH07G055508 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12 +64.0 64036 2.2 CTCF PKNOX1 DDX20 WRNIP1 CEBPG RELA FOXM1 POLR2A EED IKZF2 VOPP1 GC07P055491 GC07P055550
GH07G055473 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.5 +97.3 97280 6.1 CTCF RAD21 ZIC2 POLR2A EED SMC3 FOSL2 FOS IKZF2 MTA2 VOPP1 GC07M055478 PIR53216
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VOPP1 on UCSC Golden Path with GeneCards custom track

Promoters for VOPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212712 1455 2201 HDGF AGO1 SIN3A DMAP1 ZNF766 CBX5 FOS SP3 SP5 REST

Genomic Location for VOPP1 Gene

Chromosome:
7
Start:
55,434,406 bp from pter
End:
55,573,355 bp from pter
Size:
138,950 bases
Orientation:
Minus strand

Genomic View for VOPP1 Gene

Genes around VOPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VOPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VOPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VOPP1 Gene

Proteins for VOPP1 Gene

  • Protein details for VOPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AW1-VOPP1_HUMAN
    Recommended name:
    Vesicular, overexpressed in cancer, prosurvival protein 1
    Protein Accession:
    Q96AW1
    Secondary Accessions:
    • B0AZU1
    • B2RAT4
    • B3KS72
    • C9JWR3
    • Q6FIE3
    • Q8NBN8
    • Q96RE5
    • Q9H0W4

    Protein attributes for VOPP1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK82888.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for VOPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VOPP1 Gene

Post-translational modifications for VOPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VOPP1 Gene

Domains & Families for VOPP1 Gene

Protein Domains for VOPP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96AW1

UniProtKB/Swiss-Prot:

VOPP1_HUMAN :
  • Belongs to the VOPP1/ECOP family.
Family:
  • Belongs to the VOPP1/ECOP family.
genes like me logo Genes that share domains with VOPP1: view

No data available for Gene Families for VOPP1 Gene

Function for VOPP1 Gene

Molecular function for VOPP1 Gene

UniProtKB/Swiss-Prot Function:
Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.

Gene Ontology (GO) - Molecular Function for VOPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with VOPP1: view
genes like me logo Genes that share phenotypes with VOPP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VOPP1

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VOPP1 Gene

Localization for VOPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VOPP1 Gene

Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VOPP1 gene
Compartment Confidence
endosome 4
plasma membrane 3
extracellular 3
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for VOPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IDA,IEA 20571887
GO:0031301 integral component of organelle membrane IDA 20571887
genes like me logo Genes that share ontologies with VOPP1: view

Pathways & Interactions for VOPP1 Gene

SuperPathways for VOPP1 Gene

No Data Available

Interacting Proteins for VOPP1 Gene

Gene Ontology (GO) - Biological Process for VOPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with VOPP1: view

No data available for Pathways by source and SIGNOR curated interactions for VOPP1 Gene

Drugs & Compounds for VOPP1 Gene

No Compound Related Data Available

Transcripts for VOPP1 Gene

Unigene Clusters for VOPP1 Gene

Vesicular, overexpressed in cancer, prosurvival protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VOPP1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - -
SP13: - - - -
SP14: - - -

ExUns: 17b · 17c · 17d · 17e · 17f · 17g · 17h · 17i
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for VOPP1 Gene

GeneLoc Exon Structure for
VOPP1
ECgene alternative splicing isoforms for
VOPP1

Expression for VOPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VOPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VOPP1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VOPP1 Gene



Protein tissue co-expression partners for VOPP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VOPP1 Gene:

VOPP1

SOURCE GeneReport for Unigene cluster for VOPP1 Gene:

Hs.488307

mRNA Expression by UniProt/SwissProt for VOPP1 Gene:

Q96AW1-VOPP1_HUMAN
Tissue specificity: Widely expressed with highest levels in thymus and ovary.

Evidence on tissue expression from TISSUES for VOPP1 Gene

  • Nervous system(4.8)
  • Lung(4.4)
  • Spleen(4.4)
  • Blood(4.3)
  • Eye(2)
genes like me logo Genes that share expression patterns with VOPP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for VOPP1 Gene

Orthologs for VOPP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VOPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VOPP1 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia VOPP1 34 35
  • 87.15 (n)
dog
(Canis familiaris)
Mammalia VOPP1 34 35
  • 84.92 (n)
mouse
(Mus musculus)
Mammalia Vopp1 34 16 35
  • 84.11 (n)
rat
(Rattus norvegicus)
Mammalia Vopp1 34
  • 83.91 (n)
oppossum
(Monodelphis domestica)
Mammalia VOPP1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VOPP1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves VOPP1 34 35
  • 74.55 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia vopp1 34
  • 71.81 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19741 34
zebrafish
(Danio rerio)
Actinopterygii vopp1 34 35
  • 65.38 (n)
VOPP1 (1 of 2) 35
  • 43 (a)
OneToMany
Species where no ortholog for VOPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VOPP1 Gene

ENSEMBL:
Gene Tree for VOPP1 (if available)
TreeFam:
Gene Tree for VOPP1 (if available)

Paralogs for VOPP1 Gene

No data available for Paralogs for VOPP1 Gene

Variants for VOPP1 Gene

Sequence variations from dbSNP and Humsavar for VOPP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000023890 -- 55,548,636(+) CGCCT(A/G)CTACT intron-variant
rs1000035364 -- 55,548,976(+) GAGAC(G/T)GGCCA intron-variant
rs1000042283 -- 55,469,601(+) AACAG(A/G)GTTGG intron-variant
rs1000047186 -- 55,453,747(+) TAAAA(A/T)GTGAG intron-variant
rs1000109684 -- 55,472,799(+) GAAGA(C/T)AGAAA intron-variant, reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VOPP1 Gene

Variant ID Type Subtype PubMed ID
dgv6360n100 CNV loss 25217958
dgv6361n100 CNV loss 25217958
esv2734425 CNV deletion 23290073
esv28230 CNV gain+loss 19812545
esv3571865 CNV loss 25503493
esv3613244 CNV gain 21293372
esv997261 CNV deletion 20482838
nsv1017797 CNV gain 25217958
nsv1019204 CNV gain 25217958
nsv1020959 CNV gain 25217958
nsv469822 CNV gain 16826518
nsv472715 CNV novel sequence insertion 20440878
nsv981471 CNV duplication 23825009

Variation tolerance for VOPP1 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VOPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VOPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VOPP1 Gene

Disorders for VOPP1 Gene

Relevant External Links for VOPP1

Human Genome Epidemiology (HuGE) Navigator
VOPP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VOPP1

No disorders were found for VOPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VOPP1 Gene

Publications for VOPP1 Gene

  1. ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner. (PMID: 15735698) Park S. … James C.D. (Oncogene 2005) 2 3 4 22 64
  2. Intracellular localization of GASP/ECOP/VOPP1. (PMID: 20571887) Baras A. … Moskaluk C.A. (J. Mol. Histol. 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4 64

Products for VOPP1 Gene

Sources for VOPP1 Gene

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