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Aliases for VNN3 Gene

Aliases for VNN3 Gene

  • Vanin 3 2 3
  • EC 4 63
  • Vanin-3 3 4
  • Pantetheinase-Associated Gene Expressed In Leukocytes (PAGEL)-Alpha 3
  • Vascular Non-Inflammatory Molecule 3 3
  • Pantetheinase Pseudogene 3
  • Vanin 1 Pseudogene 3
  • HSA238982 3
  • EC 3.5.1 63

External Ids for VNN3 Gene

Previous GeneCards Identifiers for VNN3 Gene

  • GC06M132667
  • GC06M132891
  • GC06M132979
  • GC06M133026
  • GC06M133027
  • GC06M133085
  • GC06M130618
  • GC06M133046

Summaries for VNN3 Gene

Entrez Gene Summary for VNN3 Gene

  • This gene is the central gene in a cluster of three vanin genes on chromosome 6q23-q24. Extensive alternative splicing has been described; the two most common variants are represented as RefSeqs. [provided by RefSeq, Apr 2014]

GeneCards Summary for VNN3 Gene

VNN3 (Vanin 3) is a Protein Coding gene. GO annotations related to this gene include pantetheine hydrolase activity. An important paralog of this gene is VNN2.

UniProtKB/Swiss-Prot for VNN3 Gene

  • Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VNN3 Gene

Genomics for VNN3 Gene

Regulatory Elements for VNN3 Gene

Genomic Location for VNN3 Gene

132,722,787 bp from pter
132,734,765 bp from pter
11,979 bases
Minus strand

Genomic View for VNN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VNN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VNN3 Gene

Proteins for VNN3 Gene

  • Protein details for VNN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vascular non-inflammatory molecule 3
    Protein Accession:
    Secondary Accessions:
    • B2DFY0
    • B2DFY1
    • B2DFY3
    • B2DFY5
    • B2DFY6
    • B2DFY7
    • B2DFY8
    • Q3SX90
    • Q9BQY2

    Protein attributes for VNN3 Gene

    501 amino acids
    Molecular mass:
    56118 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VNN3 Gene

neXtProt entry for VNN3 Gene

Proteomics data for VNN3 Gene at MOPED

Selected DME Specific Peptides for VNN3 Gene

Post-translational modifications for VNN3 Gene

  • Glycosylation at Asn39, Asn147, Asn270, and Asn358
  • Modification sites at PhosphoSitePlus

Domains for VNN3 Gene

Gene Families for VNN3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9NY84
  • Contains 1 CN hydrolase domain.
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
genes like me logo Genes that share domains with VNN3: view

Function for VNN3 Gene

Molecular function for VNN3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: (R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol
UniProtKB/Swiss-Prot Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
UniProtKB/Swiss-Prot Induction: By Th17/Th1 type cytokines, but not by Th2-type.

Enzyme Numbers (IUBMB) for VNN3 Gene

Gene Ontology (GO) - Molecular Function for VNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds --
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides --
GO:0017159 pantetheine hydrolase activity NAS 11491533
genes like me logo Genes that share ontologies with VNN3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VNN3

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VNN3 Gene

Localization for VNN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VNN3 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=According to PubMed:11491533, secreted. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for VNN3 Gene COMPARTMENTS Subcellular localization image for VNN3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for VNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005615 extracellular space --
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with VNN3: view

Pathways for VNN3 Gene

SuperPathways for VNN3 Gene

No Data Available

Interacting Proteins for VNN3 Gene

Gene Ontology (GO) - Biological Process for VNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006807 nitrogen compound metabolic process IEA --
GO:0008150 biological_process ND --
GO:0015939 pantothenate metabolic process --
genes like me logo Genes that share ontologies with VNN3: view

No data available for Pathways by source for VNN3 Gene

Transcripts for VNN3 Gene

Unigene Clusters for VNN3 Gene

Vanin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VNN3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VNN3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -

Relevant External Links for VNN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VNN3 Gene

mRNA expression in normal human tissues for VNN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VNN3 Gene

This gene is overexpressed in Whole Blood (32.6) and Liver (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VNN3 Gene

SOURCE GeneReport for Unigene cluster for VNN3 Gene Hs.183656

mRNA Expression by UniProt/SwissProt for VNN3 Gene

Tissue specificity: Widely expressed with higher expression in liver and blood. Expressed in differentiated keratinocytes in epidermis and in epithelial cells in dermis. Overexpressed in lesional psoriatic skin.
genes like me logo Genes that share expressions with VNN3: view

In Situ Assay Products

Orthologs for VNN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for VNN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VNN3 36
  • 99 (a)
(Mus musculus)
Mammalia Vnn3 16
Vnn3 36
  • 29 (a)
(Monodelphis domestica)
Mammalia VNN3 36
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 4 (a)
-- 36
  • 27 (a)
(Gallus gallus)
Aves -- 36
  • 27 (a)
VNN1 36
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta Btd 36
  • 10 (a)
CG32750 36
  • 8 (a)
CG32751 36
  • 9 (a)
vanin-like 36
  • 8 (a)
vanin-like 37
  • 29 (a)
Species with no ortholog for VNN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VNN3 Gene

Gene Tree for VNN3 (if available)
Gene Tree for VNN3 (if available)

Paralogs for VNN3 Gene

Paralogs for VNN3 Gene

Selected SIMAP similar genes for VNN3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with VNN3: view

Variants for VNN3 Gene

Sequence variations from dbSNP and Humsavar for VNN3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs764262 -- 132,734,471(+) TAAAA(G/T)GGTAA intron-variant
rs764263 -- 132,734,473(+) AAAGG(C/G)TAATA intron-variant
rs764264 - 132,734,595(+) CCGCA(C/T)GCTCA utr-variant-5-prime, nc-transcript-variant
rs767147 -- 132,736,522(-) TTTCA(A/G)ATAAC upstream-variant-2KB
rs767148 -- 132,736,655(-) CTCTC(C/G)TTTAA upstream-variant-2KB

Relevant External Links for VNN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VNN3 Gene

Disorders for VNN3 Gene

No disorders were found for VNN3 Gene.

No data available for UniProtKB/Swiss-Prot for VNN3 Gene

Publications for VNN3 Gene

  1. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PMID: 19322213) Jansen P.A.M. … Schalkwijk J. (J. Invest. Dermatol. 2009) 2 3 4 23
  2. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PMID: 11491533) Martin F. … Galland F. (Immunogenetics 2001) 3 4 23
  3. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. (PMID: 18805469) Nitto T. … Node K. (Gene 2008) 3 4 23
  4. An ESTs description of the new vanin gene family conserved from fly to human. (PMID: 10501839) Granjeaud S. … Galland F. (Immunogenetics 1999) 2 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for VNN3 Gene

Sources for VNN3 Gene

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