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Aliases for VNN3 Gene

Aliases for VNN3 Gene

  • Vanin 3 2 3 5
  • EC 3.5.1.92 4 63
  • Vanin-3 3 4
  • Pantetheinase-Associated Gene Expressed In Leukocytes (PAGEL)-Alpha 3
  • Pantetheinase Pseudogene 3
  • Vanin 1 Pseudogene 3
  • HSA238982 3
  • EC 3.5.1 63

External Ids for VNN3 Gene

Previous GeneCards Identifiers for VNN3 Gene

  • GC06M132667
  • GC06M132891
  • GC06M132979
  • GC06M133026
  • GC06M133027
  • GC06M133085
  • GC06M130618
  • GC06M133046

Summaries for VNN3 Gene

Entrez Gene Summary for VNN3 Gene

  • This gene is the central gene in a cluster of three vanin genes on chromosome 6q23-q24. Extensive alternative splicing has been described; the two most common variants are represented as RefSeqs. [provided by RefSeq, Apr 2014]

GeneCards Summary for VNN3 Gene

VNN3 (Vanin 3) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and pantetheine hydrolase activity. An important paralog of this gene is VNN2.

UniProtKB/Swiss-Prot for VNN3 Gene

  • Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VNN3 Gene

Genomics for VNN3 Gene

Regulatory Elements for VNN3 Gene

Promoters for VNN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VNN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for VNN3 Gene

Chromosome:
6
Start:
132,722,787 bp from pter
End:
132,734,765 bp from pter
Size:
11,979 bases
Orientation:
Minus strand

Genomic View for VNN3 Gene

Genes around VNN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VNN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VNN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VNN3 Gene

Proteins for VNN3 Gene

  • Protein details for VNN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY84-VNN3_HUMAN
    Recommended name:
    Vascular non-inflammatory molecule 3
    Protein Accession:
    Q9NY84
    Secondary Accessions:
    • B2DFY0
    • B2DFY1
    • B2DFY3
    • B2DFY5
    • B2DFY6
    • B2DFY7
    • B2DFY8
    • Q3SX90
    • Q9BQY2

    Protein attributes for VNN3 Gene

    Size:
    501 amino acids
    Molecular mass:
    56118 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VNN3 Gene

neXtProt entry for VNN3 Gene

Proteomics data for VNN3 Gene at MOPED

Selected DME Specific Peptides for VNN3 Gene

Post-translational modifications for VNN3 Gene

  • Glycosylation at Asn 39, Asn 147, Asn 270, and Asn 358
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for VNN3 Gene

Gene Families for VNN3 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

Q9NY84

UniProtKB/Swiss-Prot:

VNN3_HUMAN :
  • Contains 1 CN hydrolase domain.
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
Domain:
  • Contains 1 CN hydrolase domain.
Family:
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
genes like me logo Genes that share domains with VNN3: view

Function for VNN3 Gene

Molecular function for VNN3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol.
UniProtKB/Swiss-Prot Function:
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
UniProtKB/Swiss-Prot Induction:
By Th17/Th1 type cytokines, but not by Th2-type.

Enzyme Numbers (IUBMB) for VNN3 Gene

Gene Ontology (GO) - Molecular Function for VNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0017159 pantetheine hydrolase activity IEA,NAS 11491533
genes like me logo Genes that share ontologies with VNN3: view
genes like me logo Genes that share phenotypes with VNN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VNN3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VNN3 Gene

Localization for VNN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VNN3 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=According to PubMed:11491533, secreted. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VNN3 Gene COMPARTMENTS Subcellular localization image for VNN3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for VNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with VNN3: view

Pathways & Interactions for VNN3 Gene

SuperPathways for VNN3 Gene

No Data Available

Interacting Proteins for VNN3 Gene

Gene Ontology (GO) - Biological Process for VNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with VNN3: view

No data available for Pathways by source and SIGNOR curated interactions for VNN3 Gene

Drugs & Compounds for VNN3 Gene

(2) Drugs for VNN3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteamine Approved, Investigational Pharma 23
Pantothenic acid Nutra 19

(2) Additional Compounds for VNN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pantetheine
  • (R)-Pantetheine
  • D-Pantetheine
  • Lactobacillus bulgaricus factor
  • LBF
  • Pantotheine
496-65-1
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with VNN3: view

Transcripts for VNN3 Gene

Unigene Clusters for VNN3 Gene

Vanin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VNN3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5:
SP6:

Relevant External Links for VNN3 Gene

GeneLoc Exon Structure for
VNN3
ECgene alternative splicing isoforms for
VNN3

Expression for VNN3 Gene

mRNA expression in normal human tissues for VNN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VNN3 Gene

This gene is overexpressed in Whole Blood (x32.6) and Liver (x12.5).

Protein differential expression in normal tissues from HIPED for VNN3 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VNN3 Gene



SOURCE GeneReport for Unigene cluster for VNN3 Gene Hs.183656

mRNA Expression by UniProt/SwissProt for VNN3 Gene

Q9NY84-VNN3_HUMAN
Tissue specificity: Widely expressed with higher expression in liver and blood. Expressed in differentiated keratinocytes in epidermis and in epithelial cells in dermis. Overexpressed in lesional psoriatic skin.
genes like me logo Genes that share expression patterns with VNN3: view

Protein tissue co-expression partners for VNN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for VNN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for VNN3 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia VNN3 36
  • 28 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vnn3 36
  • 29 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 4 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia VNN3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 27 (a)
ManyToMany
VNN1 36
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta vanin-like 37
  • 29 (a)
Btd 36
  • 10 (a)
ManyToMany
CG32750 36
  • 8 (a)
ManyToMany
CG32751 36
  • 9 (a)
ManyToMany
vanin-like 36
  • 8 (a)
ManyToMany
Species with no ortholog for VNN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VNN3 Gene

ENSEMBL:
Gene Tree for VNN3 (if available)
TreeFam:
Gene Tree for VNN3 (if available)

Paralogs for VNN3 Gene

Paralogs for VNN3 Gene

(3) SIMAP similar genes for VNN3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with VNN3: view

Variants for VNN3 Gene

Sequence variations from dbSNP and Humsavar for VNN3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs764264 - 132,734,595(+) CCGCA(C/T)GCTCA utr-variant-5-prime
rs36012859 - 132,734,332(-) TCTTC(A/G)CCAGG utr-variant-5-prime
rs12174042 - 132,734,326(+) GCTCT(C/G/T)CCTGG utr-variant-5-prime
rs6569834 - 132,726,885(+) CCACC(A/G)CAGCT utr-variant-5-prime
rs764262 -- 132,734,471(+) TAAAA(G/T)GGTAA intron-variant

Variation tolerance for VNN3 Gene

Gene Damage Index Score: 13.89; 95.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VNN3 Gene

HapMap Linkage Disequilibrium report
VNN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VNN3 Gene

Disorders for VNN3 Gene

Relevant External Links for VNN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VNN3

No disorders were found for VNN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VNN3 Gene

Publications for VNN3 Gene

  1. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PMID: 19322213) Jansen P.A.M. … Schalkwijk J. (J. Invest. Dermatol. 2009) 2 3 4 23 67
  2. Pharmacologic concentrations of ascorbic acid cause diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. (PMID: 19932582) Lin Z.Y. … Chuang W.L. (Biomed. Pharmacother. 2010) 2 3
  3. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. (PMID: 18805469) Nitto T. … Node K. (Gene 2008) 3 23
  4. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PMID: 11491533) Martin F. … Galland F. (Immunogenetics 2001) 3 23
  5. An ESTs description of the new vanin gene family conserved from fly to human. (PMID: 10501839) Granjeaud S. … Galland F. (Immunogenetics 1999) 2 3

Products for VNN3 Gene

Sources for VNN3 Gene

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