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VNN2 Gene

protein-coding   GIFtS: 64
GCID: GC06M133065

Vanin 2

  Search for VNN2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vanin 21 2     vanin-22
pantetheinase1 2     Vannin 22
Glycosylphosphatidyl Inositol-Anchored Protein GPI-802 3     Vascular Non-Inflammatory Molecule 22
EC 3.5.1.923 8     Vanin-23
FOAP-42     Protein FOAP-43
GPI-802     EC 3.5.18

External Ids:    HGNC: 127061   Entrez Gene: 88752   Ensembl: ENSG000001123037   OMIM: 6035715   UniProtKB: O954983   

Export aliases for VNN2 gene to outside databases

Previous GC identifers: GC06M132688 GC06M132912 GC06M133000 GC06M133045 GC06M133106 GC06M130639


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VNN2 Gene:
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each
other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which
have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been
demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role
in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in
transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional
orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for VNN2 Gene:
VNN2 (vanin 2) is a protein-coding gene. GO annotations related to this gene include pantetheine hydrolase activity. An important paralog of this gene is VNN1.

UniProtKB/Swiss-Prot: VNN2_HUMAN, O95498
Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus
recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow
cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil

Gene Wiki entry for VNN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VNN2 gene promoter:
         c-Fos   TBP   AP-1   TFIID   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VNN2 promoter sequence
   Search Chromatin IP Primers for VNN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VNN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23-q24

VNN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VNN2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M133065:  view genomic region     (about GC identifiers)

Start:
133,065,009 bp from pter      End:
133,084,598 bp from pter
Size:
19,590 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for VNN2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VNN2_HUMAN, O95498 (See protein sequence)
Recommended Name: Vascular non-inflammatory molecule 2 precursor  
Size: 520 amino acids; 58503 Da
Secondary accessions: A0AUZ3 A6NDY1 A8K4E3 A8K7W0 B2DFZ0 B2DFZ1 B2DFZ2 B2DFZ3 F6XL73 Q2XUN1
Q9UJF3 Q9UMW2
Alternative splicing: 6 isoforms:  O95498-1   O95498-2   O95498-3   O95498-4   O95498-5   O95498-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VNN2: NX_O95498

Explore proteomics data for VNN2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn39, Asn273, Asn347, Asn357, Asn411, Asn468
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for VNN2 (O95498)
     LVARYHK  YLEDIPDP  FHSAWAMGM  TRFEMFSLSGTFGT 


    See VNN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_511043.1  NP_001229279.1  NP_004656.2  

    ENSEMBL proteins: 
     ENSP00000387572   ENSP00000322276   ENSP00000406536   ENSP00000376190   ENSP00000436822  
     ENSP00000436863   ENSP00000436935   ENSP00000434077   ENSP00000433285   ENSP00000432516  
     ENSP00000432582   ENSP00000431451   ENSP00000434210   ENSP00000431680  

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    Sino Biological Cell Lysate for VNN2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VNN: Vanins

    2 InterPro protein domains:
     IPR003010 C-N_Hydrolase
     IPR012101 Biotinidase_euk

    Graphical View of Domain Structure for InterPro Entry O95498

    ProtoNet protein and cluster: O95498

    1 Blocks protein domain: IPB003010 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase

    UniProtKB/Swiss-Prot: VNN2_HUMAN, O95498
    Similarity: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family
    Similarity: Contains 1 CN hydrolase domain


    Find genes that share domains with VNN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VNN2_HUMAN, O95498
    Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus
    recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow
    cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil
    Catalytic activity: (R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol

         Genatlas biochemistry entry for VNN2:
    vanin 2,53kDa,expressed in kidney,homolog to mouse VNN1,VNN2,involved in lymphocyte migration and cell adhesion

         Enzyme Numbers (IUBMB): EC 3.5.1.921 2 EC 3.5.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
    GO:0017159pantetheine hydrolase activity IDA11491533
         
    Find genes that share ontologies with VNN2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for VNN2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

    Animal Models:
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    hsa-mir-335-5p (MIRT016760), hsa-mir-26b-5p (MIRT028816), hsa-mir-124-3p (MIRT022124)

    Block miRNA regulation of human, mouse, rat VNN2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate VNN2:
    hsa-miR-3613-3p hsa-miR-129-3p hsa-miR-1322 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidVNN2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VNN2_HUMAN, O95498: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with VNN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VNN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Pantothenate and CoA biosynthesis
    Pantothenate and CoA biosynthesis


    Find genes that share SuperPaths with VNN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for VNN2):
        Pantothenate and CoA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VNN2
    Interactions:

        GeneGlobe Interaction Network for VNN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for VNN2 (O954983 ENSP000003222764) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB2P051073, ENSP000003032424I2D: score=3 STRING: ENSP00000303242
    PANK3ENSP000002392314STRING: ENSP00000239231
    PANK4ENSP000003677274STRING: ENSP00000367727
    HIBCHENSP000003527064STRING: ENSP00000352706
    AMD1ENSP000003578804STRING: ENSP00000357880
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006807nitrogen compound metabolic process ----
    GO:0006928cellular component movement TAS9790769
    GO:0015939pantothenate metabolic process IDA11491533

    Find genes that share ontologies with VNN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VNN2

    5 Novoseek inferred chemical compound relationships for VNN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fmlp 47.5 4 11497222 (1), 17543284 (1)
    dmso 44.3 14 15839205 (4), 12749849 (4), 17623299 (1)
    retinoic acid 25.3 11 15839205 (3), 12749849 (1)
    tyrosine 1.34 6 10772340 (3), 11818440 (1)
    lipid 0 3 15128041 (2), 17623299 (1)



    Find genes that share compounds with VNN2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VNN2 gene (3 alternative transcripts): 
    NM_078488.2  NM_001242350.2  NM_004665.4  

    Unigene Cluster for VNN2:

    Vanin 2
    Hs.293130  [show with all ESTs]
    Unigene Representative Sequence: D89974
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418593(uc003qds.3) ENST00000326499(uc003qdt.3 uc010kgb.3 uc003qdv.3)
    ENST00000422400 ENST00000392389 ENST00000525270 ENST00000525674 ENST00000525289
    ENST00000532053 ENST00000528801 ENST00000533835 ENST00000531279 ENST00000526157
    ENST00000526192 ENST00000524919 ENST00000530536 ENST00000532012
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate VNN2:
    hsa-miR-3613-3p hsa-miR-129-3p hsa-miR-1322 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidVNN2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB026705.1 AB435062.1 AB435063.1 AB435064.1 AB435065.1 AJ132100.1 AK290908.1 AK292125.1 
    AK298719.1 BC064641.1 BC126145.1 BC126147.1 BC144064.1 D89974.1 NR_034173.1 NR_034174.1 

    6 DOTS entries:

    DT.106001  DT.100749932  DT.422203  DT.100019176  DT.91687898  DT.75163273 

    Selected AceView cDNA sequences (see all 36):

    NM_004665 AW452610 NM_078488 AU107381 CR609799 AU100135 AW574558 AA715743 
    AI439981 AA746352 BC064641 AB026705 BM919468 BG398557 BX388195 BX344729 
    BX344728 D89974 AJ132100 AI439194 AI439972 AI983895 AW504231 BQ050239 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VNN2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                                                          -     -                                             
    SP2:                                                                          -     -                 -                           
    SP3:              -     -     -     -     -                                   -                                                   
    SP4:                                                                          -     -                                             
    SP5:              -     -     -     -     -                                   -     -                                             


    ECgene alternative splicing isoforms for VNN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VNN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGACCAGC
    VNN2 Expression
    About this image


    VNN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    VNN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VNN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.293130

    UniProtKB/Swiss-Prot: VNN2_HUMAN, O95498
    Tissue specificity: Widely expressed with higher expression in spleen and blood

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VNN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VNN2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    platypus
    (Ornithorhynchus anatinus)
    Mammalia VNN26
    vanin 2
    66(a)
    1 ↔ 1
    Ultra520(1603111-1619710)
    chicken
    (Gallus gallus)
    Aves VNN16
    --
    Uncharacterized protein
    63(a)
    61(a)
    many ↔ many
    many ↔ many
    3(56091510-56098068)
    3(56080843-56088624)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    62(a)
    1 → many
    GL343200.1(4437940-4448295)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35993
    Btd1
    Biotinidase1 30(a)
    (best of 2)3
    44.78(n)1
    35.56(a)1
      5E13
    315521  NM_132070.21  NP_572298.11 


    ENSEMBL Gene Tree for VNN2 (if available)
    TreeFam Gene Tree for VNN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VNN2 gene
    VNN12  BTD2  VNN32  
    3 SIMAP similar genes for VNN2 using alignment to 10 protein entries:     VNN2_HUMAN (see all proteins):
    VNN3    VNN1    BTD

    Find genes that share paralogs with VNN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VNN2 (see all 635)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896647301,2
    --130639534(+) GATAAA/CTGCTT 5 -- ds5001 int10--------
    rs757558291,2
    C--130639548(+) TTGTGC/TTTTTT 5 -- ds5001 int10--------
    rs1405338721,2
    C--130639548(+) TTGTG-/TTTTTT 5 -- ds5001 int10--------
    rs7611261,2
    C,F,A--130639571(+) TTGAAC/TTTAAA 5 -- ds5001 int118Minor allele frequency- T:0.17NA NS WA CSA EA 572
    rs352964031,2
    C,F--130639578(-) AAGTAT/GTTTTA 5 -- ds5001 int16Minor allele frequency- G:0.08NS EA 306
    rs1815073991,2
    --130639603(+) CAGAAA/GATAAA 5 -- ds5001 int10--------
    rs350623321,2
    C,F--130639630(-) TTAAAG/TAACTG 5 -- ds5001 int17Minor allele frequency- T:0.07NS WA NA 424
    rs77629461,2
    C,F,A,H--130639797(+) AATTAC/TGCCAT 5 -- ds5001 int119Minor allele frequency- T:0.07NA NS EA WA 1524
    rs77629541,2
    C,F,A,H--130639821(+) GACAGC/TTGGGG 5 -- ds5001 int112Minor allele frequency- T:0.07NS EA WA NA 958
    rs77450941,2
    C,F,H--130639828(+) GGGGCT/CATGAG 5 -- ds5001 int120Minor allele frequency- C:0.08NS EA WA NA 2524

    HapMap Linkage Disequilibrium report for VNN2 (133065009 - 133084598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for VNN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662373CNV Deletion23128226
    nsv517934CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VNN2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603571    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for VNN2:
    Cystinosis

    Find genes that share disorders with VNN2           About GenesLikeMe

    Genetic Association Database (GAD): VNN2
    Human Genome Epidemiology (HuGE) Navigator: VNN2 (2 documents)

    Export disorders for VNN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VNN2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with VNN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PubMed id 9790769)1, 2, 3, 9 Galland F.... Naquet P. (Genomics 1998)
    2. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PubMed id 11491533)1, 2, 3 Martin F....Galland F. (Immunogenetics 2001)
    3. A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration. (PubMed id 10201959)1, 2, 9 Suzuki K....Sendo F. (J. Immunol. 1999)
    4. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. (PubMed id 18805469)1, 2 Nitto T.... Node K. (Gene 2008)
    5. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (Breast Cancer Res. Treat. 2008)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration. (PubMed id 14748512)1, 9 Yoshitake H....Araki Y. (Immunobiology 2003)
    10. Structural divergence of GPI-80 in activated human neutrophils. (PubMed id 17543284)1, 9 Nitto T....Araki Y. (Biochem. Biophys. Res. Commun. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8875 HGNC: 12706 AceView: VNN2 Ensembl:ENSG00000112303 euGenes: HUgn8875
    ECgene: VNN2 Kegg: 8875 H-InvDB: VNN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VNN2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/vnn2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VNN2 gene:
    Search GeneIP for patents involving VNN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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