Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VNN2 Gene

Aliases for VNN2 Gene

  • Vanin 2 2 3 5
  • Glycosylphosphatidyl Inositol-Anchored Protein GPI-80 3 4
  • Pantetheinase 2 3
  • EC 3.5.1.92 4 61
  • Vascular Non-Inflammatory Molecule 2 3
  • Protein FOAP-4 4
  • Vannin 2 3
  • EC 3.5.1 61
  • Vanin-2 4
  • FOAP-4 3
  • GPI-80 3

External Ids for VNN2 Gene

Previous GeneCards Identifiers for VNN2 Gene

  • GC06M132688
  • GC06M132912
  • GC06M133000
  • GC06M133045
  • GC06M133106
  • GC06M130639
  • GC06M133065

Summaries for VNN2 Gene

Entrez Gene Summary for VNN2 Gene

  • This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for VNN2 Gene

VNN2 (Vanin 2) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and pantetheine hydrolase activity. An important paralog of this gene is VNN1.

UniProtKB/Swiss-Prot for VNN2 Gene

  • Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

Gene Wiki entry for VNN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VNN2 Gene

Genomics for VNN2 Gene

Regulatory Elements for VNN2 Gene

Enhancers for VNN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G132748 1.5 FANTOM5 Ensembl ENCODE 78.4 +14.3 14293 1.3 ELF3 PKNOX1 ARNT FEZF1 RAD21 YY1 CEBPB ATF4 KLF16 CEBPA VNN2 VNN3 STX7 SLC18B1 ENSG00000234484
GH06G132755 1.4 FANTOM5 Ensembl ENCODE 63.9 +6.1 6059 4.0 FOXA2 ZFP64 FEZF1 ZNF384 EBF1 RAD21 EED RELB IKZF2 MAFK VNN2 ENSG00000234484 VNN3 STX7 SLC18B1
GH06G132746 0.8 FANTOM5 ENCODE 89.1 +17.2 17151 0.3 CTCF ZBTB17 VNN2 STX7 SLC18B1 ENSG00000234484 VNN3
GH06G132510 1.7 FANTOM5 ENCODE dbSUPER 9.6 +250.7 250703 4.4 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 STX7 VNN2 VNN1 MOXD1
GH06G132797 1.1 ENCODE 10.6 -35.3 -35291 2.7 HDGF CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 SLC18B1 VNN2 GC06M132772
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VNN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for VNN2 Gene

Chromosome:
6
Start:
132,743,870 bp from pter
End:
132,763,459 bp from pter
Size:
19,590 bases
Orientation:
Minus strand

Genomic View for VNN2 Gene

Genes around VNN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VNN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VNN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VNN2 Gene

Proteins for VNN2 Gene

  • Protein details for VNN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95498-VNN2_HUMAN
    Recommended name:
    Vascular non-inflammatory molecule 2
    Protein Accession:
    O95498
    Secondary Accessions:
    • A0AUZ3
    • A6NDY1
    • A8K4E3
    • A8K7W0
    • B2DFZ0
    • B2DFZ1
    • B2DFZ2
    • B2DFZ3
    • F6XL73
    • Q2XUN1
    • Q9UJF3
    • Q9UMW2

    Protein attributes for VNN2 Gene

    Size:
    520 amino acids
    Molecular mass:
    58503 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VNN2 Gene

neXtProt entry for VNN2 Gene

Selected DME Specific Peptides for VNN2 Gene

O95498:
  • TRFEMFSLSGTFGT
  • YLEDIPDP
  • LVARYHK
  • FHSAWAMGM

Post-translational modifications for VNN2 Gene

  • Glycosylation at Asn39, Asn273, posLast=347347, Asn357, Asn411, and posLast=468468
  • Modification sites at PhosphoSitePlus

Domains & Families for VNN2 Gene

Gene Families for VNN2 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

O95498

UniProtKB/Swiss-Prot:

VNN2_HUMAN :
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
Family:
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
genes like me logo Genes that share domains with VNN2: view

Function for VNN2 Gene

Molecular function for VNN2 Gene

GENATLAS Biochemistry:
vanin 2,53kDa,expressed in kidney,homolog to mouse VNN1,VNN2,involved in lymphocyte migration and cell adhesion
UniProtKB/Swiss-Prot CatalyticActivity:
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol.
UniProtKB/Swiss-Prot Function:
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

Enzyme Numbers (IUBMB) for VNN2 Gene

Gene Ontology (GO) - Molecular Function for VNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA --
GO:0017159 pantetheine hydrolase activity TAS --
genes like me logo Genes that share ontologies with VNN2: view
genes like me logo Genes that share phenotypes with VNN2: view

Animal Model Products

miRNA for VNN2 Gene

miRTarBase miRNAs that target VNN2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VNN2 Gene

Localization for VNN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VNN2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VNN2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for VNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with VNN2: view

Pathways & Interactions for VNN2 Gene

genes like me logo Genes that share pathways with VNN2: view

Gene Ontology (GO) - Biological Process for VNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006807 nitrogen compound metabolic process IEA --
GO:0006928 movement of cell or subcellular component TAS 9790769
GO:0015939 pantothenate metabolic process TAS --
genes like me logo Genes that share ontologies with VNN2: view

No data available for SIGNOR curated interactions for VNN2 Gene

Drugs & Compounds for VNN2 Gene

(4) Drugs for VNN2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteamine Approved, Investigational Pharma 27
Water Approved Pharma 0
Pantothenic acid Vet_approved Nutra 26

(5) Additional Compounds for VNN2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pantetheine
  • (R)-Pantetheine
  • D-Pantetheine
  • Lactobacillus bulgaricus factor
  • LBF
  • Pantotheine
496-65-1
genes like me logo Genes that share compounds with VNN2: view

Transcripts for VNN2 Gene

Unigene Clusters for VNN2 Gene

Vanin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VNN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: - - - -
SP7:
SP8: -

Relevant External Links for VNN2 Gene

GeneLoc Exon Structure for
VNN2
ECgene alternative splicing isoforms for
VNN2

Expression for VNN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VNN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VNN2 Gene

This gene is overexpressed in Whole Blood (x49.3).

Protein differential expression in normal tissues from HIPED for VNN2 Gene

This gene is overexpressed in Blymphocyte (35.9), Peripheral blood mononuclear cells (8.1), and Islet of Langerhans (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VNN2 Gene



NURSA nuclear receptor signaling pathways regulating expression of VNN2 Gene:

VNN2

SOURCE GeneReport for Unigene cluster for VNN2 Gene:

Hs.293130

mRNA Expression by UniProt/SwissProt for VNN2 Gene:

O95498-VNN2_HUMAN
Tissue specificity: Widely expressed with higher expression in spleen and blood.

Evidence on tissue expression from TISSUES for VNN2 Gene

  • Blood(4.9)
  • Bone marrow(4.3)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with VNN2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VNN2 Gene

Orthologs for VNN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for VNN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VNN2 34 35
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia VNN2 34 35
  • 86.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VNN2 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves VNN1 35
  • 63 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Btd 34 35
  • 44.78 (n)
CG3599 36
  • 30 (a)
vanin-like 36 35
  • 27 (a)
CG32751 35
  • 25 (a)
ManyToMany
CG32750 35
  • 23 (a)
ManyToMany
Species where no ortholog for VNN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VNN2 Gene

ENSEMBL:
Gene Tree for VNN2 (if available)
TreeFam:
Gene Tree for VNN2 (if available)

Paralogs for VNN2 Gene

Paralogs for VNN2 Gene

genes like me logo Genes that share paralogs with VNN2: view

Variants for VNN2 Gene

Sequence variations from dbSNP and Humsavar for VNN2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs864622023 Uncertain significance 132,755,930(-) CGTGA(A/C)TCCAC intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000216262 -- 132,749,459(+) AACCC(A/C)CTAGC intron-variant
rs1000281253 -- 132,764,998(+) ATAAA(C/T)TAAGA upstream-variant-2KB
rs1000447346 -- 132,765,252(+) TGTCT(C/G)CCTCA upstream-variant-2KB
rs1000665915 -- 132,743,241(+) AACAT(A/G)GGGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VNN2 Gene

Variant ID Type Subtype PubMed ID
dgv1219e214 CNV loss 21293372
esv2662373 CNV deletion 23128226
esv3610841 CNV loss 21293372
esv3610842 CNV gain 21293372
esv3610843 CNV loss 21293372
esv3610846 CNV gain 21293372
esv3610847 CNV loss 21293372
nsv517934 CNV loss 19592680

Variation tolerance for VNN2 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VNN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VNN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VNN2 Gene

Disorders for VNN2 Gene

Relevant External Links for VNN2

Genetic Association Database (GAD)
VNN2
Human Genome Epidemiology (HuGE) Navigator
VNN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VNN2

No disorders were found for VNN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VNN2 Gene

Publications for VNN2 Gene

  1. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PMID: 9790769) Galland F. … Naquet P. (Genomics 1998) 2 3 4 22 64
  2. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PMID: 11491533) Martin F. … Galland F. (Immunogenetics 2001) 2 3 4 64
  3. A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration. (PMID: 10201959) Suzuki K. … Sendo F. (J. Immunol. 1999) 3 4 22 64
  4. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PMID: 19322213) Jansen P.A.M. … Schalkwijk J. (J. Invest. Dermatol. 2009) 4 22 64
  5. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. (PMID: 18805469) Nitto T. … Node K. (Gene 2008) 3 4 64

Products for VNN2 Gene

Sources for VNN2 Gene

Content
Loading form....