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Aliases for VNN2 Gene

Aliases for VNN2 Gene

  • Vanin 2 2 3
  • Glycosylphosphatidyl Inositol-Anchored Protein GPI-80 3 4
  • Pantetheinase 2 3
  • EC 3.5.1.92 4 64
  • Vanin-2 3 4
  • Vascular Non-Inflammatory Molecule 2 3
  • Protein FOAP-4 4
  • Vannin 2 3
  • EC 3.5.1 64
  • FOAP-4 3
  • GPI-80 3

External Ids for VNN2 Gene

Summaries for VNN2 Gene

Entrez Gene Summary for VNN2 Gene

  • This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for VNN2 Gene

VNN2 (Vanin 2) is a Protein Coding gene. Among its related pathways are Pantothenate and CoA biosynthesis. GO annotations related to this gene include pantetheine hydrolase activity. An important paralog of this gene is VNN1.

UniProtKB/Swiss-Prot for VNN2 Gene

  • Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

Gene Wiki entry for VNN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VNN2 Gene

Genomics for VNN2 Gene

Genomic Location for VNN2 Gene

Start:
132,743,870 bp from pter
End:
132,763,459 bp from pter
Size:
19,590 bases
Orientation:
Minus strand

Genomic View for VNN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VNN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VNN2 Gene

Regulatory Elements for VNN2 Gene

Proteins for VNN2 Gene

  • Protein details for VNN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95498-VNN2_HUMAN
    Recommended name:
    Vascular non-inflammatory molecule 2
    Protein Accession:
    O95498
    Secondary Accessions:
    • A0AUZ3
    • A6NDY1
    • A8K4E3
    • A8K7W0
    • B2DFZ0
    • B2DFZ1
    • B2DFZ2
    • B2DFZ3
    • F6XL73
    • Q2XUN1
    • Q9UJF3
    • Q9UMW2

    Protein attributes for VNN2 Gene

    Size:
    520 amino acids
    Molecular mass:
    58503 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VNN2 Gene

neXtProt entry for VNN2 Gene

Proteomics data for VNN2 Gene at MOPED

Selected DME Specific Peptides for VNN2 Gene

Post-translational modifications for VNN2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn39, Asn273, Asn347, Asn357, Asn411, and Asn468

Domains for VNN2 Gene

Gene Families for VNN2 Gene

HGNC:

UniProtKB/Swiss-Prot:

VNN2_HUMAN
Domain:
  • Contains 1 CN hydrolase domain.:
    • O95498
Family:
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.:
    • O95498
genes like me logo Genes that share domains with VNN2: view

Function for VNN2 Gene

Molecular function for VNN2 Gene

GENATLAS Biochemistry: vanin 2,53kDa,expressed in kidney,homolog to mouse VNN1,VNN2,involved in lymphocyte migration and cell adhesion
UniProtKB/Swiss-Prot CatalyticActivity: (R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol
UniProtKB/Swiss-Prot Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

Enzyme Numbers (IUBMB) for VNN2 Gene

Gene Ontology (GO) - Molecular Function for VNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds --
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides --
GO:0017159 pantetheine hydrolase activity IDA 11491533
genes like me logo Genes that share ontologies with VNN2: view
genes like me logo Genes that share phenotypes with VNN2: view

miRNA for VNN2 Gene

miRTarBase miRNAs that target VNN2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for VNN2 Gene

Localization for VNN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VNN2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VNN2 Gene COMPARTMENTS Subcellular localization image for VNN2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with VNN2: view

Pathways for VNN2 Gene

genes like me logo Genes that share pathways with VNN2: view

Pathways by source for VNN2 Gene

1 KEGG pathway for VNN2 Gene

Gene Ontology (GO) - Biological Process for VNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006807 nitrogen compound metabolic process --
GO:0006928 movement of cell or subcellular component TAS 9790769
GO:0015939 pantothenate metabolic process IDA 11491533
genes like me logo Genes that share ontologies with VNN2: view

Compounds for VNN2 Gene

(5) Novoseek inferred chemical compound relationships for VNN2 Gene

Compound -log(P) Hits PubMed IDs
fmlp 47.5 2
dmso 44.3 9
retinoic acid 25.3 4
tyrosine 1.34 4
lipid 0 3
genes like me logo Genes that share compounds with VNN2: view

Transcripts for VNN2 Gene

Unigene Clusters for VNN2 Gene

Vanin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VNN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: - - - -
SP7:
SP8: -

Relevant External Links for VNN2 Gene

GeneLoc Exon Structure for
VNN2
ECgene alternative splicing isoforms for
VNN2

Expression for VNN2 Gene

mRNA expression in normal human tissues for VNN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VNN2 Gene

This gene is overexpressed in Whole Blood (49.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VNN2 Gene

SOURCE GeneReport for Unigene cluster for VNN2 Gene Hs.293130

mRNA Expression by UniProt/SwissProt for VNN2 Gene

O95498-VNN2_HUMAN
Tissue specificity: Widely expressed with higher expression in spleen and blood.
genes like me logo Genes that share expressions with VNN2: view

Orthologs for VNN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for VNN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VNN2 36
  • 99.33 (n)
  • 100 (a)
VNN2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VNN2 36
  • 86.22 (n)
  • 80.51 (a)
VNN2 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VNN2 37
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 37
  • 61 (a)
ManyToMany
VNN1 37
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Btd 36
  • 44.78 (n)
  • 35.56 (a)
Btd 37
  • 23 (a)
ManyToMany
CG32750 37
  • 23 (a)
ManyToMany
CG32751 37
  • 25 (a)
ManyToMany
vanin-like 37
  • 24 (a)
ManyToMany
vanin-like 38
  • 27 (a)
CG3599 38
  • 30 (a)
Species with no ortholog for VNN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VNN2 Gene

ENSEMBL:
Gene Tree for VNN2 (if available)
TreeFam:
Gene Tree for VNN2 (if available)

Paralogs for VNN2 Gene

Paralogs for VNN2 Gene

Selected SIMAP similar genes for VNN2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with VNN2: view

Variants for VNN2 Gene

Sequence variations from dbSNP and Humsavar for VNN2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs761126 -- 132,743,457(+) TTGAA(C/T)TTAAA downstream-variant-500B
rs1063993 -- 132,752,635(-) TCTAT(G/T)ATCCT intron-variant, reference, missense, nc-transcript-variant
rs1063994 -- 132,744,266(-) TCATA(C/T)GCTTG utr-variant-3-prime, nc-transcript-variant
rs1883613 -- 132,755,924(+) GGACA(C/T)GTGGA reference, synonymous-codon, nc-transcript-variant, intron-variant
rs1883617 -- 132,751,511(+) TAAAT(A/G)CCACT intron-variant, synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for VNN2 Gene

Variant ID Type Subtype PubMed ID
nsv517934 CNV Loss 19592680
esv2662373 CNV Deletion 23128226

Relevant External Links for VNN2 Gene

HapMap Linkage Disequilibrium report
VNN2

Disorders for VNN2 Gene

(1) University of Copenhagen DISEASES for VNN2 Gene

Relevant External Links for VNN2

Genetic Association Database (GAD)
VNN2
Human Genome Epidemiology (HuGE) Navigator
VNN2
genes like me logo Genes that share disorders with VNN2: view

No data available for UniProtKB/Swiss-Prot for VNN2 Gene

Publications for VNN2 Gene

  1. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PMID: 9790769) Galland F. … Naquet P. (Genomics 1998) 2 3 4 23
  2. A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration. (PMID: 10201959) Suzuki K. … Sendo F. (J. Immunol. 1999) 3 4 23
  3. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PMID: 11491533) Martin F. … Galland F. (Immunogenetics 2001) 2 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for VNN2 Gene

Sources for VNN2 Gene

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