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Aliases for VNN1 Gene

Aliases for VNN1 Gene

  • Vanin 1 2 3
  • Vascular Non-Inflammatory Molecule 1 3 4
  • Pantetheine Hydrolase 3 4
  • EC 3.5.1.92 4 63
  • Vanin-1 3 4
  • HDLCQ8 3 6
  • Tiff66 3 4
  • Pantetheinase 3
  • Vannin 1 3
  • EC 3.5.1 63

External Ids for VNN1 Gene

Previous GeneCards Identifiers for VNN1 Gene

  • GC06M132625
  • GC06M132849
  • GC06M132938
  • GC06M132983
  • GC06M133044
  • GC06M130576
  • GC06M133001

Summaries for VNN1 Gene

Entrez Gene Summary for VNN1 Gene

  • This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

GeneCards Summary for VNN1 Gene

VNN1 (Vanin 1) is a Protein Coding gene. Among its related pathways are Pantothenate and CoA biosynthesis. GO annotations related to this gene include GPI anchor binding and pantetheine hydrolase activity. An important paralog of this gene is VNN2.

UniProtKB/Swiss-Prot for VNN1 Gene

  • Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

Gene Wiki entry for VNN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VNN1 Gene

Genomics for VNN1 Gene

Regulatory Elements for VNN1 Gene

Genomic Location for VNN1 Gene

Start:
132,680,858 bp from pter
End:
132,714,055 bp from pter
Size:
33,198 bases
Orientation:
Minus strand

Genomic View for VNN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VNN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VNN1 Gene

Proteins for VNN1 Gene

  • Protein details for VNN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95497-VNN1_HUMAN
    Recommended name:
    Pantetheinase
    Protein Accession:
    O95497
    Secondary Accessions:
    • A8K310
    • Q4JFW6
    • Q4VAS7
    • Q4VAS8
    • Q4VAS9
    • Q9UF16
    • Q9UJF4

    Protein attributes for VNN1 Gene

    Size:
    513 amino acids
    Molecular mass:
    57012 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VNN1 Gene

neXtProt entry for VNN1 Gene

Proteomics data for VNN1 Gene at MOPED

Post-translational modifications for VNN1 Gene

  • Glycosylation at Asn38, Asn130, Asn200, Asn283, Asn315, and Asn353
  • Modification sites at PhosphoSitePlus

Other Protein References for VNN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for VNN1 Gene

Gene Families for VNN1 Gene

HGNC:

Suggested Antigen Peptide Sequences for VNN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95497

UniProtKB/Swiss-Prot:

VNN1_HUMAN :
  • O95497
Domain:
  • Contains 1 CN hydrolase domain.
Family:
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
genes like me logo Genes that share domains with VNN1: view

Function for VNN1 Gene

Molecular function for VNN1 Gene

GENATLAS Biochemistry:
vanin 1,55kDa,expressed in spleen,thymus,peripheral blood lymphocytes,small intestine with homology to biotinidase,homolog to mouse VNN1,involved in lymphocyte migration in cell adhesion and in the colonization of the thymus by hematopoietic precursor cells
UniProtKB/Swiss-Prot CatalyticActivity:
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol
UniProtKB/Swiss-Prot Function:
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
UniProtKB/Swiss-Prot Induction:
By Th17/Th1 type cytokines, but not by Th2-type.

Enzyme Numbers (IUBMB) for VNN1 Gene

Gene Ontology (GO) - Molecular Function for VNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds --
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides --
GO:0017159 pantetheine hydrolase activity IDA 11491533
GO:0034235 GPI anchor binding TAS 17145956
genes like me logo Genes that share ontologies with VNN1: view
genes like me logo Genes that share phenotypes with VNN1: view

Animal Models for VNN1 Gene

MGI Knock Outs for VNN1:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VNN1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for VNN1 Gene

Localization for VNN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VNN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VNN1 Gene COMPARTMENTS Subcellular localization image for VNN1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane TAS 17145956
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with VNN1: view

Pathways for VNN1 Gene

genes like me logo Genes that share pathways with VNN1: view

Pathways by source for VNN1 Gene

1 KEGG pathway for VNN1 Gene

Interacting Proteins for VNN1 Gene

Gene Ontology (GO) - Biological Process for VNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response ISS 14966568
GO:0002544 chronic inflammatory response ISS 14966568
GO:0006807 nitrogen compound metabolic process --
GO:0006928 movement of cell or subcellular component TAS 9790769
GO:0006954 inflammatory response ISS 15282320
genes like me logo Genes that share ontologies with VNN1: view

Compounds for VNN1 Gene

(4) HMDB Compounds for VNN1 Gene

Compound Synonyms Cas Number PubMed IDs
Cysteamine
  • (2-Mercaptoethyl)amine
60-23-1
Pantetheine
  • (R)-Pantetheine
496-65-1
Pantothenic acid
  • (+)-Pantothenate
79-83-4
Water
  • Dihydrogen oxide
7732-18-5

(2) Novoseek inferred chemical compound relationships for VNN1 Gene

Compound -log(P) Hits PubMed IDs
pantetheine 94 6
guanidine hydrochloride 47.8 4
genes like me logo Genes that share compounds with VNN1: view

Transcripts for VNN1 Gene

mRNA/cDNA for VNN1 Gene

(9) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VNN1 Gene

Vanin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VNN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VNN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2:
SP3: -

Relevant External Links for VNN1 Gene

GeneLoc Exon Structure for
VNN1
ECgene alternative splicing isoforms for
VNN1

Expression for VNN1 Gene

mRNA expression in normal human tissues for VNN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VNN1 Gene

This gene is overexpressed in Whole Blood (32.7) and Liver (12.0).

Protein differential expression in normal tissues for VNN1 Gene

This gene is overexpressed in Pancreatic juice (29.5), Neutrophil (17.5), and Serum (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VNN1 Gene

SOURCE GeneReport for Unigene cluster for VNN1 Gene Hs.12114

mRNA Expression by UniProt/SwissProt for VNN1 Gene

O95497-VNN1_HUMAN
Tissue specificity: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.
genes like me logo Genes that share expressions with VNN1: view

In Situ Assay Products

No data available for Expression partners for VNN1 Gene

Orthologs for VNN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VNN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VNN1 35
  • 85.08 (n)
  • 82.46 (a)
VNN1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VNN1 35
  • 85.22 (n)
  • 80.85 (a)
-- 36
  • 76 (a)
OneToMany
VNN1 36
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Vnn1 35
  • 78.72 (n)
  • 76.28 (a)
Vnn1 16
Vnn1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VNN1 35
  • 99.68 (n)
  • 99.42 (a)
VNN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vnn1 35
  • 80.48 (n)
  • 78.67 (a)
oppossum
(Monodelphis domestica)
Mammalia VNN1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VNN1 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves VNN1 35
  • 66.74 (n)
  • 66.81 (a)
-- 36
  • 63 (a)
ManyToMany
VNN1 36
  • 64 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia vnn2 35
  • 63.94 (n)
  • 63.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3599 37
  • 31 (a)
Btd 36
  • 24 (a)
ManyToMany
CG32750 36
  • 23 (a)
ManyToMany
CG32751 36
  • 24 (a)
ManyToMany
vanin-like 36
  • 24 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012357 35
  • 41.02 (n)
  • 34.29 (a)
Species with no ortholog for VNN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VNN1 Gene

ENSEMBL:
Gene Tree for VNN1 (if available)
TreeFam:
Gene Tree for VNN1 (if available)

Paralogs for VNN1 Gene

Paralogs for VNN1 Gene

Selected SIMAP similar genes for VNN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VNN1: view

Variants for VNN1 Gene

Sequence variations from dbSNP and Humsavar for VNN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs742516 -- 132,693,484(+) CTAAA(C/T)TGGGC intron-variant
rs752776 -- 132,693,346(+) AAAAA(A/T)TTATT intron-variant
rs909975 -- 132,693,852(+) TCCAC(A/G)CTTTA intron-variant
rs909976 -- 132,693,879(+) TTTGC(C/G)CCTAC intron-variant
rs909977 -- 132,693,902(+) GTGTG(C/T)TTATC intron-variant

Relevant External Links for VNN1 Gene

HapMap Linkage Disequilibrium report
VNN1
Human Gene Mutation Database (HGMD)
VNN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VNN1 Gene

Disorders for VNN1 Gene

(1) University of Copenhagen DISEASES for VNN1 Gene

Relevant External Links for VNN1

Genetic Association Database (GAD)
VNN1
Human Genome Epidemiology (HuGE) Navigator
VNN1
genes like me logo Genes that share disorders with VNN1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for VNN1 Gene

Publications for VNN1 Gene

  1. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PMID: 9790769) Galland F. … Naquet P. (Genomics 1998) 2 3 4 23
  2. Is pantetheinase the actual identity of mouse and human vanin-1 proteins? (PMID: 10567687) Maras B. … Pitari G. (FEBS Lett. 1999) 3 4 23
  3. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PMID: 11491533) Martin F. … Galland F. (Immunogenetics 2001) 3 4 23
  4. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PMID: 19322213) Jansen P.A.M. … Schalkwijk J. (J. Invest. Dermatol. 2009) 3 4 23
  5. Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. (PMID: 8934567) Aurrand-Lions M. … Naquet P. (Immunity 1996) 3 23

Products for VNN1 Gene

Sources for VNN1 Gene

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