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Aliases for VNN1 Gene

Aliases for VNN1 Gene

  • Vanin 1 2 3 5
  • Vascular Non-Inflammatory Molecule 1 3 4
  • Pantetheine Hydrolase 3 4
  • EC 4 63
  • Vanin-1 3 4
  • Tiff66 3 4
  • Vannin 1 3
  • EC 3.5.1 63
  • HDLCQ8 3

External Ids for VNN1 Gene

Previous GeneCards Identifiers for VNN1 Gene

  • GC06M132625
  • GC06M132849
  • GC06M132938
  • GC06M132983
  • GC06M133044
  • GC06M130576
  • GC06M133001

Summaries for VNN1 Gene

Entrez Gene Summary for VNN1 Gene

  • This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

GeneCards Summary for VNN1 Gene

VNN1 (Vanin 1) is a Protein Coding gene. Diseases associated with VNN1 include Malaria. Among its related pathways are Pantothenate and CoA biosynthesis. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and GPI anchor binding. An important paralog of this gene is VNN2.

UniProtKB/Swiss-Prot for VNN1 Gene

  • Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

Gene Wiki entry for VNN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VNN1 Gene

Genomics for VNN1 Gene

Regulatory Elements for VNN1 Gene

Enhancers for VNN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VNN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VNN1 Gene

132,680,858 bp from pter
132,714,055 bp from pter
33,198 bases
Minus strand

Genomic View for VNN1 Gene

Genes around VNN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VNN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VNN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VNN1 Gene

Proteins for VNN1 Gene

  • Protein details for VNN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K310
    • Q4JFW6
    • Q4VAS7
    • Q4VAS8
    • Q4VAS9
    • Q9UF16
    • Q9UJF4

    Protein attributes for VNN1 Gene

    513 amino acids
    Molecular mass:
    57012 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for VNN1 Gene

neXtProt entry for VNN1 Gene

Proteomics data for VNN1 Gene at MOPED

Post-translational modifications for VNN1 Gene

  • Glycosylation at Asn 38, Asn 130, Asn 200, Asn 283, Asn 315, and Asn 353
  • Modification sites at PhosphoSitePlus

Other Protein References for VNN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for VNN1 Gene

Gene Families for VNN1 Gene


Suggested Antigen Peptide Sequences for VNN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CN hydrolase domain.
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
  • Contains 1 CN hydrolase domain.
  • Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
genes like me logo Genes that share domains with VNN1: view

Function for VNN1 Gene

Molecular function for VNN1 Gene

GENATLAS Biochemistry:
vanin 1,55kDa,expressed in spleen,thymus,peripheral blood lymphocytes,small intestine with homology to biotinidase,homolog to mouse VNN1,involved in lymphocyte migration in cell adhesion and in the colonization of the thymus by hematopoietic precursor cells
UniProtKB/Swiss-Prot CatalyticActivity:
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol.
UniProtKB/Swiss-Prot Function:
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
UniProtKB/Swiss-Prot Induction:
By Th17/Th1 type cytokines, but not by Th2-type.

Enzyme Numbers (IUBMB) for VNN1 Gene

genes like me logo Genes that share phenotypes with VNN1: view

Animal Models for VNN1 Gene

MGI Knock Outs for VNN1:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VNN1 Gene

Localization for VNN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VNN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for VNN1 Gene COMPARTMENTS Subcellular localization image for VNN1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
peroxisome 2
lysosome 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for VNN1 Gene

Pathways & Interactions for VNN1 Gene

genes like me logo Genes that share pathways with VNN1: view

Pathways by source for VNN1 Gene

1 KEGG pathway for VNN1 Gene

Interacting Proteins for VNN1 Gene

Gene Ontology (GO) - Biological Process for VNN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response ISS 14966568
GO:0006768 biotin metabolic process IBA --
GO:0006807 nitrogen compound metabolic process IEA --
GO:0006928 movement of cell or subcellular component TAS 9790769
GO:0006954 inflammatory response IEA,ISS 15282320
genes like me logo Genes that share ontologies with VNN1: view

No data available for SIGNOR curated interactions for VNN1 Gene

Drugs & Compounds for VNN1 Gene

(2) Drugs for VNN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteamine Approved, Investigational Pharma 26
Pantothenic acid Nutra 25

(3) Additional Compounds for VNN1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (R)-Pantetheine
  • D-Pantetheine
  • Lactobacillus bulgaricus factor
  • LBF
  • Pantotheine
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with VNN1: view

Transcripts for VNN1 Gene

mRNA/cDNA for VNN1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VNN1 Gene

Vanin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VNN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP3: -

Relevant External Links for VNN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VNN1 Gene

mRNA expression in normal human tissues for VNN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VNN1 Gene

This gene is overexpressed in Whole Blood (x32.7) and Liver (x12.0).

Protein differential expression in normal tissues from HIPED for VNN1 Gene

This gene is overexpressed in Pancreatic juice (29.5), Neutrophil (17.5), and Serum (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VNN1 Gene

SOURCE GeneReport for Unigene cluster for VNN1 Gene Hs.12114

mRNA Expression by UniProt/SwissProt for VNN1 Gene

Tissue specificity: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.
genes like me logo Genes that share expression patterns with VNN1: view

Primer Products

No data available for Protein tissue co-expression partners for VNN1 Gene

Orthologs for VNN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VNN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VNN1 35
  • 85.08 (n)
  • 82.46 (a)
VNN1 36
  • 80 (a)
(Canis familiaris)
Mammalia VNN1 35
  • 85.22 (n)
  • 80.85 (a)
-- 36
  • 76 (a)
VNN1 36
  • 73 (a)
(Mus musculus)
Mammalia Vnn1 35
  • 78.72 (n)
  • 76.28 (a)
Vnn1 16
Vnn1 36
  • 75 (a)
(Pan troglodytes)
Mammalia VNN1 35
  • 99.68 (n)
  • 99.42 (a)
VNN1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Vnn1 35
  • 80.48 (n)
  • 78.67 (a)
(Monodelphis domestica)
Mammalia VNN1 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia VNN1 36
  • 66 (a)
(Gallus gallus)
Aves VNN1 35
  • 66.74 (n)
  • 66.81 (a)
-- 36
  • 63 (a)
VNN1 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vnn2 35
  • 63.94 (n)
  • 63.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3599 37
  • 31 (a)
Btd 36
  • 24 (a)
CG32750 36
  • 23 (a)
CG32751 36
  • 24 (a)
vanin-like 36
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012357 35
  • 41.02 (n)
  • 34.29 (a)
Species with no ortholog for VNN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VNN1 Gene

Gene Tree for VNN1 (if available)
Gene Tree for VNN1 (if available)

Paralogs for VNN1 Gene

Paralogs for VNN1 Gene

(3) SIMAP similar genes for VNN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VNN1: view

Variants for VNN1 Gene

Sequence variations from dbSNP and Humsavar for VNN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2294757 - 132,713,959(+) CTGCA(A/G)TGAAA reference, missense
VAR_023967 -
rs2272996 - 132,694,132(+) TAGAG(C/T)TGTTC reference, missense
rs45610032 - 132,694,118(-) ATGTT(C/G)TGGCA reference, missense
rs45624336 - 132,694,088(-) CATGC(A/C/G)ATACC reference, missense

Variation tolerance for VNN1 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.23; 88.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VNN1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VNN1 Gene

Disorders for VNN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for VNN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search VNN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VNN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with VNN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VNN1 Gene

Publications for VNN1 Gene

  1. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PMID: 9790769) Galland F. … Naquet P. (Genomics 1998) 2 3 4 23 67
  2. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PMID: 19322213) Jansen P.A.M. … Schalkwijk J. (J. Invest. Dermatol. 2009) 3 23
  3. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. (PMID: 17145956) Berruyer C. … Galland F. (J. Exp. Med. 2006) 3 23
  4. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PMID: 11491533) Martin F. … Galland F. (Immunogenetics 2001) 3 23
  5. Is pantetheinase the actual identity of mouse and human vanin-1 proteins? (PMID: 10567687) Maras B. … Pitari G. (FEBS Lett. 1999) 3 23

Products for VNN1 Gene

Sources for VNN1 Gene