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VNN1 Gene

protein-coding   GIFtS: 64
GCID: GC06M133001

Vanin 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vanin 11 2     pantetheinase2
Pantetheine Hydrolase2 3     vanin-12
Vascular Non-Inflammatory Molecule 12 3     Vannin 12
Tiff662 3     Vanin-13
EC 3.5.1.923 8     EC 3.5.18
HDLCQ82 5     

External Ids:    HGNC: 127051   Entrez Gene: 88762   Ensembl: ENSG000001122997   OMIM: 6035705   UniProtKB: O954973   

Export aliases for VNN1 gene to outside databases

Previous GC identifers: GC06M132625 GC06M132849 GC06M132938 GC06M132983 GC06M133044 GC06M130576


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VNN1 Gene:
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each
other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which
have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been
demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role
in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface
molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of
T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional
orientation as, two other vanin genes on chromosome 6q23-q24. (provided by RefSeq, Feb 2009)

GeneCards Summary for VNN1 Gene:
VNN1 (vanin 1) is a protein-coding gene. Diseases associated with VNN1 include cystinosis, and thymoma. GO annotations related to this gene include pantetheine hydrolase activity and GPI anchor binding. An important paralog of this gene is BTD.

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497
Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus
recycling pantothenic acid (vitamin B5) and releasing cysteamine

Gene Wiki entry for VNN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the VNN1 gene promoter:
         USF1   PPAR-gamma1   USF-1   RREB-1   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVNN1 promoter sequence
   Search Chromatin IP Primers for VNN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VNN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23-q24

VNN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VNN1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M133001:  view genomic region     (about GC identifiers)

Start:
133,001,997 bp from pter      End:
133,035,194 bp from pter
Size:
33,198 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497 (See protein sequence)
Recommended Name: Pantetheinase precursor  
Size: 513 amino acids; 57012 Da
Secondary accessions: A8K310 Q4JFW6 Q4VAS7 Q4VAS8 Q4VAS9 Q9UF16 Q9UJF4

Explore the universe of human proteins at neXtProt for VNN1: NX_O95497

Explore proteomics data for VNN1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38, Asn130, Asn200, Asn283, Asn315, Asn353
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for VNN1 (O95497) (see all 9)
     GNYTVCQ  LVARYHK  YLEDIPDP  VNWTSYAS 


    See VNN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004657.2  
    ENSEMBL proteins: 
     ENSP00000356905  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VNN: Vanins

    2 InterPro protein domains:
     IPR003010 C-N_Hydrolase
     IPR012101 Biotinidase_euk

    Graphical View of Domain Structure for InterPro Entry O95497

    ProtoNet protein and cluster: O95497

    1 Blocks protein domain: IPB003010 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase

    UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497
    Similarity: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family
    Similarity: Contains 1 CN hydrolase domain


    VNN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VNN1_HUMAN, O95497
    Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus
    recycling pantothenic acid (vitamin B5) and releasing cysteamine
    Catalytic activity: (R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol
    Induction: By Th17/Th1 type cytokines, but not by Th2-type

         Genatlas biochemistry entry for VNN1:
    vanin 1,55kDa,expressed in spleen,thymus,peripheral blood lymphocytes,small intestine with homology to
    biotinidase,homolog to mouse VNN1,involved in lymphocyte migration in cell adhesion and in the colonization of
    the thymus by hematopoietic precursor cells

         Enzyme Numbers (IUBMB): EC 3.5.1.921 2 EC 3.5.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
    GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
    GO:0017159pantetheine hydrolase activity IDA11491533
    GO:0034235GPI anchor binding TAS17145956
         
    VNN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VNN1:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vnn1):
     behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     other 

    VNN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vnn1tm1Pna for VNN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VNN1
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    hsa-miR-183* hsa-miR-548p hsa-miR-548t hsa-miR-4311 hsa-miR-4309 hsa-miR-1279 hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidVNN1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VNN1_HUMAN, O95497: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane TAS17145956
    GO:0031225anchored component of membrane IEA--

    VNN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VNN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Pantothenate and CoA biosynthesis
    Pantothenate and CoA biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for VNN1):
        Pantothenate and CoA biosynthesis


    VNN1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VNN1
    Interactions:

        Search GeneGlobe Interaction Network for VNN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for VNN1 (ENSP000003569054) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PANK3ENSP000002392314STRING: ENSP00000239231
    PANK4ENSP000003677274STRING: ENSP00000367727
    HIBCHENSP000003527064STRING: ENSP00000352706
    AMD1ENSP000003578804STRING: ENSP00000357880
    PACSIN1ENSP000002444584STRING: ENSP00000244458
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002526acute inflammatory response ISS14966568
    GO:0002544chronic inflammatory response ISS14966568
    GO:0006807nitrogen compound metabolic process ----
    GO:0006928cellular component movement TAS9790769
    GO:0006954inflammatory response ISS15282320

    VNN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VNN1

    4 HMDB Compounds for VNN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cysteamine(2-Mercaptoethyl)amine (see all 30)60-23-1--
    Pantetheine(R)-Pantetheine (see all 5)496-65-1--
    Pantothenic acid(+)-Pantothenate (see all 14)79-83-4--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for VNN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pantetheine 94 6 10691189 (3), 8590605 (2), 20018163 (1)
    guanidine hydrochloride 47.8 5 10691189 (2), 8590605 (2)



    VNN1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VNN1 gene: 
    NM_004666.2  

    Unigene Cluster for VNN1:

    Vanin 1
    Hs.12114  [show with all ESTs]
    Unigene Representative Sequence: NM_004666
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367928(uc003qdn.3 uc003qdo.3)
    miRNA
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    hsa-miR-183* hsa-miR-548p hsa-miR-548t hsa-miR-4311 hsa-miR-4309 hsa-miR-1279 hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidVNN1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AJ132099.1 AK290425.1 AK314265.1 BC096265.3 BC096266.3 BC096267.3 BC096268.1 U39664.1 

    4 DOTS entries:

    DT.407202  DT.91687534  DT.121389503  DT.95091209 

    Selected AceView cDNA sequences (see all 47):

    AI640361 AI762340 AI625852 AW264804 AI863511 AI793191 CA415661 AI985105 
    AI253190 AW614263 AI700952 BU683071 AK095461 AA983530 U39664 AA074379 
    AA166710 AI081684 BM763699 BG533352 AW270903 AA377003 AI733906 NM_004666 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for VNN1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                -     -     -                           
    SP2:                                                                        
    SP3:                                            -                           


    ECgene alternative splicing isoforms for VNN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VNN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCTGCA
    VNN1 Expression
    About this image


    VNN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Kidney (Urinary System)
             Metanephros
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    VNN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VNN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12114

    UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497
    Tissue specificity: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional
    psoriatic skin

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VNN1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vnn11 , 5 vanin 11, 5 78.72(n)1
    76.28(a)1
      10 (11.33 cM)5
    223611  NM_011704.31  NP_035834.21 
     238946885 
    chicken
    (Gallus gallus)
    Aves VNN11 vanin 1 66.74(n)
    66.81(a)
      421702  NM_001039288.2  NP_001034377.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    66(a)
    1 → many
    GL343200.1(4437940-4448295)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vnn21 vanin 2 63.94(n)
    63.73(a)
      496713  NM_001011263.1  NP_001011263.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35993   -- 31(a)   5E1   --


    ENSEMBL Gene Tree for VNN1 (if available)
    TreeFam Gene Tree for VNN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VNN1 gene
    BTD2  VNN22  VNN32  
    3 SIMAP similar genes for VNN1 using alignment to 1 protein entry:     VNN1_HUMAN:
    VNN2    VNN3    BTD

    VNN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VNN1 (see all 969)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs285388341,2
    --130605715(+) TCTCAA/CAAAAA 1 -- int1 trp30--------
    rs1399576691,2
    C--133002745(+) TTTTAA/GTGTAT 1 -- ds50010--------
    rs1841626261,2
    --133002747(+) TTAATA/GTATGT 1 -- ds50010--------
    rs126619281,2
    C,F,H--133002818(+) GCTCAC/TGCCTG 1 -- ds50016Minor allele frequency- T:0.03NA NS 190
    rs69093351,2
    C,F,A--133002852(+) TAGACG/AGGTGG 1 -- ds50018Minor allele frequency- A:0.16NS WA CSA NA 311
    rs126619541,2
    C,F,H--133002978(+) TCCCAG/ACTACA 1 -- ds50016Minor allele frequency- A:0.07NS EA 308
    rs65698211,2
    C,F,A--133002984(+) CTACAC/TAGGAG 1 -- ds500110Minor allele frequency- T:0.12NS WA CSA NA EA 550
    rs69093961,2
    C,F--133003050(+) TCACAC/TCATCG 1 -- ds50015Minor allele frequency- T:0.10NS 188
    rs28408121,2
    C,F,A--133003072(+) GGGCAA/GCAAGA 1 -- ds50019Minor allele frequency- G:0.46NS NA WA 196
    rs1423758541,2
    C--133003188(+) TATGGA/GCCAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for VNN1 (133001997 - 133035194 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VNN1: --
    Human Gene Mutation Database (HGMD): VNN1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VNN1
    DNA2.0 Custom Variant and Variant Library Synthesis for VNN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603570    OMIM disorders: --

    13 diseases for VNN1:    
    About MalaCards
    cystinosis    thymoma    chronic myeloid leukemia    diabetic nephropathy
    osteoporosis    malaria    type 1 diabetes    myeloid leukemia
    diabetes mellitus    hypertension    pancreatic cancer    pancreatitis
    leukemia

    1 disease from the University of Copenhagen DISEASES database for VNN1:
    Cystinosis

    VNN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VNN1
    Human Genome Epidemiology (HuGE) Navigator: VNN1 (2 documents)

    Export disorders for VNN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VNN1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with VNN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PubMed id 9790769)1, 2, 3, 9 Galland F.... Naquet P. (Genomics 1998)
    2. Is pantetheinase the actual identity of mouse and human vanin-1 proteins? (PubMed id 10567687)1, 2, 9 Maras B.... Pitari G. (FEBS Lett. 1999)
    3. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PubMed id 19322213)1, 2, 9 Jansen P.A.M.... Schalkwijk J. (J. Invest. Dermatol. 2009)
    4. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PubMed id 11491533)1, 2, 9 Martin F....Galland F. (Immunogenetics 2001)
    5. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PubMed id 20641033)1, 4 Lei S.F....Deng H.W. (J. Bone Miner. Res. 2011)
    6. Admixture mapping provides evidence of association of the VNN1 gene with hypertension. (PubMed id 18043751)1, 4 Zhu X. and Cooper R.S. (PLoS ONE 2007)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (Mol. Cell. Proteomics 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8876 HGNC: 12705 AceView: VNN1 Ensembl:ENSG00000112299 euGenes: HUgn8876
    ECgene: VNN1 Kegg: 8876 H-InvDB: VNN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VNN1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/vnn1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VNN1 gene:
    Search GeneIP for patents involving VNN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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