VNN1 Gene

Aliases
for VNN1 gene

Previous GC identifers: GC06M132625 GC06M132849 GC06M132938 GC06M132983 GC06M133044 GC06M130576

Summaries
for VNN1 gene

Genomic Views
for VNN1 gene

RefSeq DNA sequence:

NC_000006.11  NC_018917.1  NT_025741.15  

SwitchGear Promoter luciferase reporter plasmid: VNN1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VNN1

VNN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M133001:  view genomic region     (about GC identifiers)

Proteins
for VNN1 gene

Explore the universe of human proteins at neXtProt for VNN1: NX_O95497

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: VNN1 OriGene Custom Protein Services for VNN1
	GenScript Custom Purified and Recombinant Proteins Services for VNN1
	Novus Biologicals VNN1 Proteins Novus Biologicals VNN1 Lysates
	Sino Biological Recombinant Protein for VNN1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VNN1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	OriGene Antibodies: VNN1 OriGene Custom Antibody Services for VNN1
	GenScript Custom Superior Antibodies Services for VNN1
	Novus Biologicals VNN1 Antibodies
	Abcam antibodies for VNN1
	Uscn Antibodies for VNN1
	ThermoFisher Antibodies for VNN1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VNN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VNN1

Protein Domains /
Families
for VNN1 gene

ProtoNet protein and cluster: O95497

Function
for VNN1 gene

miRNA Products:		OriGene 3'-UTR Clone: VNN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VNN1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate VNN1:
		hsa-miR-183* hsa-miR-548p hsa-miR-548t hsa-miR-4311 hsa-miR-4309 hsa-miR-1279 hsa-miR-3182
		SwitchGear 3'UTR luciferase reporter plasmid: VNN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VNN1 (see all 6) OriGene siRNA: VNN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VNN1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for VNN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VNN1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VNN1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: VNN1 (NM_004666)
		Sino Biological Human cDNA Clone for VNN1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VNN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VNN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VNN1
		Search LifeMap BioReagents cell lines for VNN1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VNN1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Vnn1)

Pathways & Interactions
for VNN1 gene

	Super-pathway	contained gene-specific pathways
1	Vitamin B5 (pantothenate) metabolism	Pantothenate and CoA biosynthesis 0.40

1         Kegg Pathway  (Kegg details for VNN1)

Pantothenate and CoA biosynthesis

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

Drugs & Compounds
for VNN1 gene

Transcripts
for VNN1 gene

Expression
for VNN1 gene

VNN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTTCTGCA

6 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	TestisTestis CordPre-Sertoli Cells			Testis
	Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic Angioblasts			Endothelium
	Head MesenchymeBranchial Arch 1Cranial Neural Crest Cells			Neural Crest
	HeartCardiac CrescentCardiac Crescent Cells			Myocardium
	BoneZeugopod Growth Plate			Bone
	KidneyS-shaped Body			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Human kidney epithelial cell spheroids (Kidney spheroids for...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VNN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VNN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VNN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VNN1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VNN1

Orthologs
for VNN1 gene

Paralogs
for VNN1 gene

Paralogs for VNN1 gene

VNN2²  BTD²  VNN3²  

3 SIMAP similar genes for VNN1 using alignment to 1 protein entry:     VNN1_HUMAN:

VNN2    VNN3    BTD

VNN1 for paralogs           About GeneDecksing

Genomic Variants
for VNN1 gene

10/797 NCBI SNPs in VNN1 are shown (see all 797)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs454728921,2	C,F,	--	130577101(-)	TATCAT/CAGTGA	1	--	ut31		7		NS CSA WA	310
rs455801331,2	C,F,	--	130577362(-)	ATTCTT/GTAGGA	1	--	ut31		8		NS WA CSA	308
rs455492371,2	C,F,	--	130577383(-)	CACGGC/TGGTTG	1	--	ut31		8		NS WA CSA	308
rs27454251,2	C,F,H,	--	130577424(+)	CCACCC/TGAGCC	1	--	ut31		15		NS EA NA	1148
rs455770381,2	C,F,	--	130577441(-)	GGCTGC/ACATCA	1	--	ut31		8		NS WA CSA	308
rs455412401,2	C,F,	--	130577522(-)	TGAGGG/TTCAGG	1	--	ut31		8		NS WA CSA	310
rs412861761,2	C,F,	--	130577727(+)	ATGAGA/CATACA	1	--	ut31		6		NS NA	306
rs456149311,2	C,F,	--	130577884(-)	TTTTTC/TCTAAA	1	--	ut31		6		NS NA	306
rs455479321,2	C,F,	--	130578009(-)	CATAGT/CACCGA	1	--	ut31		9		NS NA WA CSA	314
rs586424581,2	C,	--	130578153(+)	ACACAC/TAATGC	1	--	ut31		2		WA	120

HapMap Linkage Disequilibrium report for VNN1 (133001997 - 133035194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for VNN1: --
Human Gene Mutation Database (HGMD): VNN1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VNN1

DNA2.0 Custom Variant and Variant Library Synthesis for VNN1

Disorders / Diseases
for VNN1 gene

Publications
for VNN1 gene

PubMed articles for VNN1 gene, integrated from 9 sources (see all 34): (articles sorted by number of sources associating them with VNN1)

Utopia: connect your pdf to the dynamic world of online information

1. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PubMed id 9790769)^{1, 2, 3, 9} Galland F.... Naquet P. (1998)
2. Is pantetheinase the actual identity of mouse and human vanin-1 proteins? (PubMed id 10567687)^{1, 2, 9} Maras B.... Pitari G. (1999)
3. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PubMed id 19322213)^{1, 2, 9} Jansen P.A.M.... Schalkwijk J. (2009)
4. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PubMed id 11491533)^{1, 2, 9} Martin F....Galland F. (2001)
5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
6. A proteomic analysis of human bile. (PubMed id 15084671)^{1, 2} Kristiansen T.Z.... Pandey A. (2004)
7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
10. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. (PubMed id 17145956)^{1, 9} Berruyer C....Galland F. (2006)

External Searches for VNN1 gene

Genome Databases showing VNN1 gene

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Products
for VNN1 gene