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VN1R5 Gene

protein-coding   GIFtS: 39
GCID: GC01P247419

Vomeronasal 1 Receptor 5 (Gene/Pseudogene)

(Previous name: vomeronasal 1 receptor 5)
  Search for VN1R5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vomeronasal 1 Receptor 5 (Gene/Pseudogene)1 2     Vomeronasal 1 Receptor 51
V1RL52 3     Pheromone Receptor2
G-Protein Coupled Receptor GPCR262 3     V1R-Like 52
hGPCR262 3     Vomeronasal Type-1 Receptor 52
V1r-Like Receptor 52 3     

External Ids:    HGNC: 198701   Entrez Gene: 3177052   Ensembl: ENSG000001976177   UniProtKB: Q7Z5H43   

Export aliases for VN1R5 gene to outside databases

Previous GC identifers: GC01U900013 GC01P243516 GC01P244366 GC01P243746 GC01P245485 GC01P217813


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for VN1R5 Gene:
VN1R5 (vomeronasal 1 receptor 5 (gene/pseudogene)) is a protein-coding gene. GO annotations related to this gene include pheromone receptor activity.

UniProtKB/Swiss-Prot: VN1R5_HUMAN, Q7Z5H4
Function: Putative pheromone receptor

Gene Wiki entry for VN1R5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VN1R5 gene promoter:
         Evi-1   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VN1R5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

VN1R5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VN1R5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P247419:  view genomic region     (about GC identifiers)

Start:
247,419,374 bp from pter      End:
247,420,447 bp from pter
Size:
1,074 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VN1R5_HUMAN, Q7Z5H4 (See protein sequence)
Recommended Name: Vomeronasal type-1 receptor 5  
Size: 357 amino acids; 40779 Da
Miscellaneous: The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes
Secondary accessions: A0AVG1 Q8NEU5 Q8TDU3

Explore the universe of human proteins at neXtProt for VN1R5: NX_Q7Z5H4

Post-translational modifications: 

  • Glycosylation2 at Asn297
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_776257.1  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VN1R: Vomeronasal receptors / Type 1
    VN1RU: GPCR / Unclassified : Vomeronasal receptors, type 1

    1 InterPro protein domain:
     IPR004072 Vmron_rcpt_1

    Graphical View of Domain Structure for InterPro Entry Q7Z5H4

    ProtoNet protein and cluster: Q7Z5H4

    UniProtKB/Swiss-Prot: VN1R5_HUMAN, Q7Z5H4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    VN1R5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VN1R5_HUMAN, Q7Z5H4
    Function: Putative pheromone receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016503pheromone receptor activity IEA--
         
    VN1R5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for VN1R5:
     Decreased Wnt reporter activit  Increased gamma-H2AX phosphory 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VN1R5_HUMAN, Q7Z5H4: Cell membrane; Multi-pass membrane protein

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    VN1R5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VN1R5
    Interactions:

        GeneGlobe Interaction Network for VN1R5

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019236response to pheromone IEA--

    VN1R5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VN1R5 gene: 
    NM_173858.1  

    Unigene Cluster for VN1R5:

    Vomeronasal 1 receptor 5 (gene/pseudogene)
    Hs.553686
    Unigene Representative Sequence: BC126341
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000472952
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    Additional mRNA sequence: 

    BC126341.1 BC126367.1 

    1 DOTS entry:

    DT.99951618 

    1 AceView cDNA sequence:

    NM_173858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VN1R5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAATTTA
    VN1R5 Expression
    About this image

    VN1R5 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.553686
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for VN1R5 (if available)
    TreeFam Gene Tree for VN1R5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VN1R5 gene
    1 SIMAP similar gene for VN1R5 using alignment to 1 protein entry:     VN1R5_HUMAN:
    VN1R17P

    VN1R5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    VN1R5_HUMAN, Q7Z5H4: There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency
    of about 32%


    Selected SNPs for VN1R5 (see all 78)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23865281,2
    C,F,A--254211291(+) GCCTGG/ACTTAT 1 -- us2k16Minor allele frequency- A:0.36NA EA 248
    rs1421589311,2
    --254211309(+) AGCACA/GATGTC 1 -- us2k10--------
    rs596581411,2
    C,F--254211328(+) TCATCC/TGTATT 1 -- us2k11Minor allele frequency- T:0.10WA 118
    rs1877345441,2
    --254211411(+) TTTATA/CCATTT 1 -- us2k10--------
    rs43887361,2
    C,F,H--254211637(+) TCTTCA/CCATCC 1 -- us2k1 tfbs3 trp316Minor allele frequency- C:0.27NS EA NA WA CSA 768
    rs1161878211,2
    C,F--254211674(+) TGTAGT/CGATCA 1 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1131581861,2
    C--254211790(+) TACAAT/-GACAT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1923426831,2
    --254211819(+) ACATTC/TTAGTA 1 -- us2k10--------
    rs1463504541,2
    C--254211822(+) TTCTAC/G/TTAACA 1 -- us2k10--------
    rs1833521821,2
    --254211850(+) AAACCA/GTATAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for VN1R5 (247419374 - 247420447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VN1R5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5299CNV Insertion18451855
    nsv833126CNV Loss17160897
    esv33129CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VN1R5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with VN1R5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PubMed id 12123587)1, 2, 3 Rodriguez I. and Mombaerts P. (Curr. Biol. 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PubMed id 12826614)1, 2 Zhang J. and Webb D.M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    4. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    5. Extreme variability among mammalian V1R gene families. (PubMed id 19952141)1 Young J.M....Trask B.J. (Genome Res. 2010)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 317705 HGNC: 19870 AceView: VN1R5 Ensembl:ENSG00000197617 euGenes: HUgn317705
    ECgene: VN1R5 H-InvDB: VN1R5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VN1R5 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/061

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VN1R5 gene:
    Search GeneIP for patents involving VN1R5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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