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VN1R4 Gene(Protein Coding)

Vomeronasal 1 Receptor 4

GCID:
GC19M053266
GIFtS:
33
Genes Participants
UDN Logo

Aliases for VN1R4 Gene

Aliases for VN1R4 Gene

  • Vomeronasal 1 Receptor 4 2 3 5
  • G-Protein Coupled Receptor GPCR27 3 4
  • V1r-Like Receptor 4 3 4
  • HGPCR27 3 4
  • V1RL4 3 4
  • Vomeronasal Type-1 Receptor 4 3
  • Pheromone Receptor 3
  • CTD-2245F17.9 3
  • V1R-Like 4 3

External Ids for VN1R4 Gene

Previous GeneCards Identifiers for VN1R4 Gene

  • GC19M054131
  • GC19M058446
  • GC19M058461
  • GC19M053770
  • GC19M050090

Summaries for VN1R4 Gene

GeneCards Summary for VN1R4 Gene

VN1R4 (Vomeronasal 1 Receptor 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and pheromone receptor activity. An important paralog of this gene is VN1R2.

UniProtKB/Swiss-Prot for VN1R4 Gene

  • Putative pheromone receptor.

Gene Wiki entry for VN1R4 Gene

Additional gene information for VN1R4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R4 Gene

Genomics for VN1R4 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for VN1R4 Gene


Top Transcription factor binding sites by QIAGEN in the VN1R4 gene promoter:

Genomic Locations for VN1R4 Gene

Genomic Locations for VN1R4 Gene
chr19:53,266,676-53,267,907
(GRCh38/hg38)
Size:
1,232 bases
Orientation:
Minus strand
chr19:53,769,929-53,770,972
(GRCh37/hg19)

Genomic View for VN1R4 Gene

Genes around VN1R4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VN1R4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VN1R4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for VN1R4 Gene

Proteins for VN1R4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for VN1R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5H5-VN1R4_HUMAN
    Recommended name:
    Vomeronasal type-1 receptor 4
    Protein Accession:
    Q7Z5H5
    Secondary Accessions:
    • Q2M3E2
    • Q7Z5H6
    • Q7Z5H7
    • Q8TDU2

    Protein attributes for VN1R4 Gene

    Size:
    301 amino acids
    Molecular mass:
    33557 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.

neXtProt entry for VN1R4 Gene

Post-translational modifications for VN1R4 Gene

  • Glycosylation at posLast=154154 and posLast=157157

Other Protein References for VN1R4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R4 Gene

Domains & Families for VN1R4 Gene

Gene Families for VN1R4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for VN1R4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for VN1R4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5H5

UniProtKB/Swiss-Prot:

VN1R4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with VN1R4: view

Function for VN1R4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for VN1R4 Gene

UniProtKB/Swiss-Prot Function:
Putative pheromone receptor.

Phenotypes From GWAS Catalog for VN1R4 Gene

Gene Ontology (GO) - Molecular Function for VN1R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0016503 pheromone receptor activity IEA --
genes like me logo Genes that share ontologies with VN1R4: view
genes like me logo Genes that share phenotypes with VN1R4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VN1R4 Gene

Localization for VN1R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VN1R4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for VN1R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VN1R4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VN1R4 Gene

Pathways & Interactions for VN1R4 Gene

SuperPathways for VN1R4 Gene

PathCards logo More details on SuperPathways for VN1R4
No Data Available

Interacting Proteins for VN1R4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310856%0d%0a9606.ENSP00000353957%0d%0a9606.ENSP00000334394%0d%0a9606.ENSP00000388311%0d%0a9606.ENSP00000311679%0d%0a9606.ENSP00000347648%0d%0a
Selected Interacting proteins: Q7Z5H5-VN1R4_HUMAN ENSP00000310856 for VN1R4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for VN1R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007606 sensory perception of chemical stimulus IBA --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with VN1R4: view

No data available for Pathways by source and SIGNOR curated interactions for VN1R4 Gene

Drugs & Compounds for VN1R4 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for VN1R4 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for VN1R4 Gene

(5) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R4 Gene

No ASD Table

Relevant External Links for VN1R4 Gene

GeneLoc Exon Structure for
VN1R4
ECgene alternative splicing isoforms for
VN1R4

Expression for VN1R4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VN1R4 Gene

mRNA expression in normal human tissues for VN1R4 Gene
mRNA expression by BioGPS for VN1R4 GenemRNA expression by GTEx for VN1R4 Gene

mRNA differential expression in normal tissues according to GTEx for VN1R4 Gene

This gene is overexpressed in Testis (x48.0) and Cervix - Endocervix (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of VN1R4 Gene:

VN1R4

SOURCE GeneReport for Unigene cluster for VN1R4 Gene:

Hs.553685
genes like me logo Genes that share expression patterns with VN1R4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VN1R4 Gene

Orthologs for VN1R4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VN1R4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia BOSTAUV1R416 33
  • 74.09 (n)
VN1R4 34
  • 62 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia VN1R4 33
  • 71.92 (n)
dog
(Canis familiaris)
 Mammalia VN1R4 33 34
  • 71.44 (n)
mouse
(Mus musculus)
 Mammalia Vmn1r237 16 33
  • 66.55 (n)
Vmn1r234 34
  • 45 (a)
 OneToMany
Vmn1r236 34
  • 43 (a)
 OneToMany
Vmn1r235 34
  • 42 (a)
 OneToMany
Vmn1r233 34
  • 42 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Vom1r21 33
  • 66.32 (n)
Species where no ortholog for VN1R4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VN1R4 Gene

ENSEMBL:
Gene Tree for VN1R4 (if available)
TreeFam:
Gene Tree for VN1R4 (if available)

Paralogs for VN1R4 Gene

Paralogs for VN1R4 Gene

(5) SIMAP similar genes for VN1R4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for VN1R4 Gene

genes like me logo Genes that share paralogs with VN1R4: view

Variants for VN1R4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R4 Gene

VN1R4_HUMAN-Q7Z5H5
Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.

Sequence variations from dbSNP and Humsavar for VN1R4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000329451 -- 53,272,122(-) C/T upstream_transcript_variant
rs1000488478 -- 53,268,230(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000736958 -- 53,264,195(-) C/T downstream_transcript_variant
rs1000860261 -- 53,269,283(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001176929 -- 53,265,337(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VN1R4 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv3644741 CNV gain 21293372
nsv1055236 CNV gain 25217958
nsv1055773 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1141887 OTHER inversion 24896259

Variation tolerance for VN1R4 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VN1R4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VN1R4

Disorders for VN1R4 Gene

Additional Disease Information for VN1R4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for VN1R4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R4 Gene

Publications for VN1R4 Gene

  1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PMID: 12123587) Rodriguez I … Mombaerts P (Current biology : CB 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J … Webb DM (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  5. Extreme variability among mammalian V1R gene families. (PMID: 19952141) Young JM … Trask BJ (Genome research 2010) 3 58

Products for VN1R4 Gene

Sources for VN1R4 Gene

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