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Aliases for VN1R4 Gene

Aliases for VN1R4 Gene

  • Vomeronasal 1 Receptor 4 2 3
  • G-Protein Coupled Receptor GPCR27 3 4
  • V1r-Like Receptor 4 3 4
  • HGPCR27 3 4
  • V1RL4 3 4
  • Vomeronasal Type-1 Receptor 4 3
  • Pheromone Receptor 3
  • V1R-Like 4 3

External Ids for VN1R4 Gene

Summaries for VN1R4 Gene

GeneCards Summary for VN1R4 Gene

VN1R4 (Vomeronasal 1 Receptor 4) is a Protein Coding gene. GO annotations related to this gene include pheromone receptor activity. An important paralog of this gene is VN1R2.

UniProtKB/Swiss-Prot for VN1R4 Gene

  • Putative pheromone receptor

Gene Wiki entry for VN1R4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R4 Gene

Genomics for VN1R4 Gene

Genomic Location for VN1R4 Gene

Start:
53,266,676 bp from pter
End:
53,267,723 bp from pter
Size:
1,048 bases
Orientation:
Minus strand

Genomic View for VN1R4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VN1R4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VN1R4 Gene

Regulatory Elements for VN1R4 Gene

Proteins for VN1R4 Gene

  • Protein details for VN1R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5H5-VN1R4_HUMAN
    Recommended name:
    Vomeronasal type-1 receptor 4
    Protein Accession:
    Q7Z5H5
    Secondary Accessions:
    • Q2M3E2
    • Q7Z5H6
    • Q7Z5H7
    • Q8TDU2

    Protein attributes for VN1R4 Gene

    Size:
    301 amino acids
    Molecular mass:
    33557 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes

neXtProt entry for VN1R4 Gene

Proteomics data for VN1R4 Gene at MOPED

Post-translational modifications for VN1R4 Gene

  • Glycosylation at Asn154 and Asn157

Other Protein References for VN1R4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R4 Gene

Domains for VN1R4 Gene

Gene Families for VN1R4 Gene

HGNC:
  • VN1R :Vomeronasal receptors / Type 1
  • VN1RU :GPCR / Unclassified : Vomeronasal receptors, type 1

Protein Domains for VN1R4 Gene

UniProtKB/Swiss-Prot:

VN1R4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q7Z5H5
genes like me logo Genes that share domains with VN1R4: view

Function for VN1R4 Gene

Molecular function for VN1R4 Gene

UniProtKB/Swiss-Prot Function: Putative pheromone receptor

Gene Ontology (GO) - Molecular Function for VN1R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0016503 pheromone receptor activity IEA --
genes like me logo Genes that share ontologies with VN1R4: view

Phenotypes for VN1R4 Gene

GenomeRNAi human phenotypes for VN1R4:
genes like me logo Genes that share phenotypes with VN1R4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VN1R4 Gene

Localization for VN1R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VN1R4 Gene COMPARTMENTS Subcellular localization image for VN1R4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for VN1R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VN1R4: view

Pathways for VN1R4 Gene

SuperPathways for VN1R4 Gene

No Data Available

Interacting Proteins for VN1R4 Gene

Gene Ontology (GO) - Biological Process for VN1R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0019236 response to pheromone IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with VN1R4: view

No data available for Pathways by source for VN1R4 Gene

Transcripts for VN1R4 Gene

mRNA/cDNA for VN1R4 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R4 Gene

No ASD Table

Relevant External Links for VN1R4 Gene

GeneLoc Exon Structure for
VN1R4
ECgene alternative splicing isoforms for
VN1R4

Expression for VN1R4 Gene

mRNA expression in normal human tissues for VN1R4 Gene

mRNA differential expression in normal tissues according to GTEx for VN1R4 Gene

This gene is overexpressed in Testis (48.0) and Cervix - Endocervix (5.0).

SOURCE GeneReport for Unigene cluster for VN1R4 Gene Hs.553685

genes like me logo Genes that share expressions with VN1R4: view

Orthologs for VN1R4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VN1R4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VN1R4 36
  • 71.92 (n)
  • 56.51 (a)
cow
(Bos Taurus)
Mammalia BOSTAUV1R416 36
  • 74.09 (n)
  • 61.79 (a)
VN1R4 37
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VN1R4 36
  • 71.44 (n)
  • 55.33 (a)
VN1R4 37
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vmn1r233 37
  • 42 (a)
OneToMany
Vmn1r234 37
  • 45 (a)
OneToMany
Vmn1r235 37
  • 42 (a)
OneToMany
Vmn1r236 37
  • 43 (a)
OneToMany
Vmn1r237 36
  • 66.55 (n)
  • 54.32 (a)
Vmn1r237 16
rat
(Rattus norvegicus)
Mammalia Vom1r21 36
  • 66.32 (n)
  • 49.13 (a)
Species with no ortholog for VN1R4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VN1R4 Gene

ENSEMBL:
Gene Tree for VN1R4 (if available)
TreeFam:
Gene Tree for VN1R4 (if available)

Paralogs for VN1R4 Gene

Paralogs for VN1R4 Gene

Selected SIMAP similar genes for VN1R4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VN1R4: view

Variants for VN1R4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R4 Gene

Q7Z5H5-VN1R4_HUMAN
Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1

Sequence variations from dbSNP and Humsavar for VN1R4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2914359 -- 53,268,431(-) CTCAC(A/G)ATGTT upstream-variant-2KB
rs2965263 -- 53,267,978(-) tgtgt(C/G)tatgt upstream-variant-2KB
rs2965264 -- 53,267,917(-) gtgaa(A/T)aaaga upstream-variant-2KB
rs8109864 -- 53,268,917(+) ATGCT(C/T)CCATT upstream-variant-2KB
rs10412309 -- 53,266,488(+) ATTGC(A/G)TAGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VN1R4 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV Deletion 23290073
nsv912342 CNV Gain 21882294
esv2718812 CNV Deletion 23290073

Relevant External Links for VN1R4 Gene

HapMap Linkage Disequilibrium report
VN1R4

Disorders for VN1R4 Gene

No disorders were found for VN1R4 Gene.

No data available for UniProtKB/Swiss-Prot for VN1R4 Gene

Publications for VN1R4 Gene

  1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PMID: 12123587) Rodriguez I. … Mombaerts P. (Curr. Biol. 2002) 2 3 4
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  3. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J. … Webb D.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for VN1R4 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate VN1R4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for VN1R4
    • Block miRNA regulation of VN1R4 using miScript Target Protectors

    Sources for VN1R4 Gene

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