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VN1R4 Gene

protein-coding   GIFtS: 42
GCID: GC19M053770

Vomeronasal 1 Receptor 4

  Search for VN1R4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vomeronasal 1 Receptor 41 2     V1r-Like Receptor 42 3
V1RL42 3     Pheromone Receptor2
G-Protein Coupled Receptor GPCR272 3     V1R-Like 42
hGPCR272 3     Vomeronasal Type-1 Receptor 42

External Ids:    HGNC: 198711   Entrez Gene: 3177032   Ensembl: ENSG000002285677   UniProtKB: Q7Z5H53   

Export aliases for VN1R4 gene to outside databases

Previous GC identifers: GC19M054131 GC19M058446 GC19M058461 GC19M050090


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for VN1R4 Gene:
VN1R4 (vomeronasal 1 receptor 4) is a protein-coding gene. GO annotations related to this gene include pheromone receptor activity. An important paralog of this gene is VN1R2.

UniProtKB/Swiss-Prot: VN1R4_HUMAN, Q7Z5H5
Function: Putative pheromone receptor

Gene Wiki entry for VN1R4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the VN1R4 gene promoter:
         POU2F1   POU2F1a   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for VN1R4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VN1R4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

VN1R4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VN1R4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M053770:  view genomic region     (about GC identifiers)

Start:
53,769,929 bp from pter      End:
53,770,972 bp from pter
Size:
1,044 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VN1R4_HUMAN, Q7Z5H5 (See protein sequence)
Recommended Name: Vomeronasal type-1 receptor 4  
Size: 301 amino acids; 33557 Da
Miscellaneous: The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes
Secondary accessions: Q2M3E2 Q7Z5H6 Q7Z5H7 Q8TDU2

Explore the universe of human proteins at neXtProt for VN1R4: NX_Q7Z5H5

Explore proteomics data for VN1R4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn154, Asn157

  • See VN1R4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_776256.2  
    ENSEMBL proteins: 
     ENSP00000310856  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VN1R: Vomeronasal receptors / Type 1
    VN1RU: GPCR / Unclassified : Vomeronasal receptors, type 1

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004072 Vmron_rcpt_1

    Graphical View of Domain Structure for InterPro Entry Q7Z5H5

    ProtoNet protein and cluster: Q7Z5H5

    1 Blocks protein domain: IPB004072 Vomeronasal type 1 receptor family signature

    UniProtKB/Swiss-Prot: VN1R4_HUMAN, Q7Z5H5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with VN1R4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VN1R4_HUMAN, Q7Z5H5
    Function: Putative pheromone receptor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0016503pheromone receptor activity IEA--
         
    Find genes that share ontologies with VN1R4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for VN1R4:
     Actin fiber cells 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VN1R4_HUMAN, Q7Z5H5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0015629actin cytoskeleton ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with VN1R4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

        Search GeneGlobe Interaction Network for VN1R4

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0019236response to pheromone IEA--
    GO:0050909sensory perception of taste ----

    Find genes that share ontologies with VN1R4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for VN1R4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VN1R4 gene: 
    NM_173857.2  

    Unigene Cluster for VN1R4:

    Vomeronasal 1 receptor 4
    Hs.553685
    Unigene Representative Sequence: BC104939
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311170(uc010ydu.2)
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      QuantiFast Probe-based Assays in human, mouse, rat VN1R4

    Additional mRNA sequence: 

    BC104935.1 BC104939.1 

    1 DOTS entry:

    DT.99953625 

    1 AceView cDNA sequence:

    NM_173857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VN1R4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTGTGACC
    VN1R4 Expression
    About this image

    VN1R4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VN1R4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553685
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for VN1R4 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vmn1r2371 , 5 vomeronasal 1 receptor 2371, 5 66.55(n)1
    54.32(a)1
      17 (11.40 cM)5
    1712341  NM_134200.11  NP_598961.11 
     213139635 


    ENSEMBL Gene Tree for VN1R4 (if available)
    TreeFam Gene Tree for VN1R4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VN1R4 gene
    VN1R22  VN1R12  
    5 SIMAP similar genes for VN1R4 using alignment to 1 protein entry:     VN1R4_HUMAN:
    VN1R2    VN1R3    VN1R1    FKSG83    VN1R17P

    Find genes that share paralogs with VN1R4           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for VN1R4 (see all 40)
    PGOHUM00000239872 PGOHUM00000248196 PGOHUM00000248813 PGOHUM00000248814 PGOHUM00000248849


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    VN1R4_HUMAN, Q7Z5H5: Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1


    Selected SNPs for VN1R4 (see all 121)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1448108591,2
    --53769542(+) GCAACC/TTCATT 1 -- ds50010--------
    rs1481630971,2
    --53769606(+) GCTACG/TTGTCA 1 -- ds50010--------
    rs1869781571,2
    --53769630(+) ACAATA/CTCACG 1 -- ds50010--------
    rs1124286731,2
    --53769634(+) TCTCAC/TGCTTA 1 -- ds50010--------
    rs1822206211,2
    --53769738(+) TTAATC/TGCGTA 1 -- ds50010--------
    rs104123091,2
    C,F,A,H--53769741(+) ATTGCG/ATAGAC 1 -- ds500113Minor allele frequency- A:0.09NS EA NA CSA WA 1424
    rs169846641,2
    C,F,H--53769861(+) TTGGGG/ATGGAA 1 -- ds500122Minor allele frequency- A:0.22NA NS EA WA CSA 2480
    rs570860641,2
    C--53769898(+) CTCATA/GATTGG 1 -- ds50014Minor allele frequency- G:0.20WA NA EA 360
    rs800413321,2
    C--53769903(+) AATTGG/TGAGAG 1 -- ds50014Minor allele frequency- T:0.19WA NA EA 360
    rs576832141,2
    C,F--53769906(+) TGGGAG/CAGGTT 1 -- ds50015Minor allele frequency- C:0.20WA CSA NA EA 362

    HapMap Linkage Disequilibrium report for VN1R4 (53769929 - 53770972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for VN1R4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718787CNV Deletion23290073
    esv2718812CNV Deletion23290073
    nsv912342CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VN1R4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with VN1R4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PubMed id 12123587)1, 2, 3 Rodriguez I. and Mombaerts P. (Curr. Biol. 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PubMed id 12826614)1, 2 Zhang J. and Webb D.M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    4. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    5. Extreme variability among mammalian V1R gene families. (PubMed id 19952141)1 Young J.M....Trask B.J. (Genome Res. 2010)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 317703 HGNC: 19871 AceView: VN1R4 Ensembl:ENSG00000228567 euGenes: HUgn317703
    ECgene: VN1R4 H-InvDB: VN1R4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VN1R4 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/061

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VN1R4 gene:
    Search GeneIP for patents involving VN1R4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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