VN1R4 Gene
protein-coding GIFtS: 40
GCID: GC19M053770
|
|
vomeronasal 1 receptor 4
| |
Aliases
for VN1R4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vomeronasal 1 Receptor 41 2 | | V1r-Like Receptor 42 3 | | V1RL41 2 3 | | Pheromone Receptor2 | | G-Protein Coupled Receptor GPCR272 3 | | V1R-Like 42 | | HGPCR271 | | Vomeronasal Type-1 Receptor 42 |
Export aliases for VN1R4 gene to outside databasesPrevious GC identifers: GC19M054131 GC19M058446 GC19M058461 GC19M050090 |
Summaries
for VN1R4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: VN1R4_HUMAN, Q7Z5H5Function: Putative pheromone receptor
Gene Wiki entry for VN1R4
|
Genomic Views
for VN1R4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VN1R4 gene promoter:
POU2F1 POU2F1a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for VN1R4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VN1R4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42VN1R4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M053770: view genomic region
(about GC identifiers)
Start:
|
53,769,929 bp from pter |
End:
|
53,770,972 bp from pter |
Size:
|
1,044 bases |
Orientation:
|
minus strand |
|
Proteins
for VN1R4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VN1R4_HUMAN, Q7Z5H5 (See
protein sequence)Recommended Name: Vomeronasal type-1 receptor 4 Size: 301 amino acids; 33557 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes
Secondary accessions: Q2M3E2 Q7Z5H6 Q7Z5H7 Q8TDU2Explore the universe of human proteins at neXtProt for VN1R4: NX_Q7Z5H5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z5H5
VN1R4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_776256.2
ENSEMBL proteins: ENSP00000310856
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
VN1R4 for ontologies About GeneDecksing
VN1R4 Antibody Products:
Assay Products for VN1R4: |
Protein
Domains /
Families
for VN1R4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VN1R4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z5H5ProtoNet protein and cluster: Q7Z5H5 1 Blocks protein family: IPB004072 Vomeronasal type 1 receptor family signature
UniProtKB/Swiss-Prot: VN1R4_HUMAN, Q7Z5H5Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for VN1R4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VN1R4_HUMAN, Q7Z5H5Function: Putative pheromone receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VN1R4 (NM_173857) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VN1R4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VN1R4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VN1R4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016503 | pheromone receptor activity |
IEA | -- |
VN1R4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for VN1R4:
|
Pathways & Interactions
for VN1R4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VN1R4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019236 | response to pheromone |
IEA | -- |
VN1R4 for ontologies About GeneDecksing
|
Drugs & Compounds
for VN1R4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VN1R4
Search CenterWatch for drugs/clinical trials and news about VN1R4
|
Transcripts
for VN1R4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VN1R4 gene: NM_173857.2 Unigene Cluster for VN1R4: Vomeronasal 1 receptor 4 Hs.553685 Unigene Representative Sequence: BC1049391 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000311170(uc010ydu.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VN1R4 (NM_173857) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VN1R4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VN1R4 |
Additional cDNA sequence: BC104935.1 BC104939.1 1 DOTS entry: DT.99953625 1 AceView cDNA sequence: NM_173857
GeneLoc Exon Structure
|
Expression
for VN1R4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VN1R4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTGTGACC
About this image
See VN1R4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VN1R4
SOURCE GeneReport for Unigene cluster: Hs.553685
SABiosciences Custom PCR Arrays for VN1R4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VN1R4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat VN1R4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VN1R4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VN1R4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VN1R4 |
Orthologs
for VN1R4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for VN1R4 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
ora11 |
olfactory receptor class A related 1 |
43.83(n)
30.77(a) |
|
553133 NM_001020504.1 NP_001018340.1 |
ENSEMBL Gene Tree for VN1R4 (if available)
TreeFam Gene Tree for VN1R4 (if available) |
Paralogs
for VN1R4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VN1R4 gene
- VN1R22 VN1R12
5 SIMAP similar genes for VN1R4 using alignment to 1 protein entry: VN1R4_HUMAN:VN1R2 VN1R3 VN1R1 FKSG83 VN1R17P
VN1R4 for paralogs About GeneDecksing
5/40 Pseudogenes.org Pseudogenes for VN1R4 (see all 40)
PGOHUM00000239872 PGOHUM00000248196 PGOHUM00000248813 PGOHUM00000248814 PGOHUM00000248849
|
Genomic Variants
for VN1R4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: VN1R4_HUMAN, Q7Z5H5Polymorphism: Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VN1R4 (53769929 - 53770972 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VN1R4: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for VN1R4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for VN1R4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VN1R4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with VN1R4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel human vomeronasal receptor-like genes reveal species-specific families. (PubMed id 12123587)1, 2, 3 Rodriguez I. and Mombaerts P. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PubMed id 12826614)1, 2 Zhang J. and Webb D.M. (2003)
- Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
- Extreme variability among mammalian V1R gene families . (PubMed id 19952141)1 Young J.M....Trask B.J. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for VN1R4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VN1R4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VN1R4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VN1R4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VN1R4 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt061.shtml |
|
| | |
About This Section
| Patent Information for VN1R4 gene:
Search GeneIP for patents involving VN1R4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VN1R4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VN1R4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VN1R4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VN1R4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VN1R4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VN1R4 | | OriGene Custom Protein Services for VN1R4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VN1R4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VN1R4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VN1R4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VN1R4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VN1R4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VN1R4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for VN1R4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | VN1R4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VN1R4 |
|  |  |  | | | | ThermoFisher Antibodies for VN1R4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VN1R4 |
|
|
|
|
