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VN1R4 Gene(Protein Coding)

Vomeronasal 1 Receptor 4

GCID:
GC19M053266
GIFtS:
41
Genes Participants
UDN Logo

Aliases for VN1R4 Gene

Aliases for VN1R4 Gene

  • Vomeronasal 1 Receptor 4 2 3 5
  • G-Protein Coupled Receptor GPCR27 3 4
  • V1r-Like Receptor 4 3 4
  • HGPCR27 3 4
  • V1RL4 3 4
  • Pheromone Receptor 3
  • V1R-Like 4 3

External Ids for VN1R4 Gene

Previous GeneCards Identifiers for VN1R4 Gene

  • GC19M054131
  • GC19M058446
  • GC19M058461
  • GC19M053770
  • GC19M050090

Summaries for VN1R4 Gene

GeneCards Summary for VN1R4 Gene

VN1R4 (Vomeronasal 1 Receptor 4) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and pheromone receptor activity. An important paralog of this gene is VN1R2.

UniProtKB/Swiss-Prot for VN1R4 Gene

  • Putative pheromone receptor.

Gene Wiki entry for VN1R4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R4 Gene

Genomics for VN1R4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for VN1R4 Gene


Transcription factor binding sites by QIAGEN in the VN1R4 gene promoter:

Genomic Location for VN1R4 Gene

Chromosome:
19
Start:
53,266,676 bp from pter
End:
53,267,907 bp from pter
Size:
1,232 bases
Orientation:
Minus strand

Genomic View for VN1R4 Gene

Genes around VN1R4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VN1R4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VN1R4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for VN1R4 Gene

Proteins for VN1R4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for VN1R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5H5-VN1R4_HUMAN
    Recommended name:
    Vomeronasal type-1 receptor 4
    Protein Accession:
    Q7Z5H5
    Secondary Accessions:
    • Q2M3E2
    • Q7Z5H6
    • Q7Z5H7
    • Q8TDU2

    Protein attributes for VN1R4 Gene

    Size:
    301 amino acids
    Molecular mass:
    33557 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.

neXtProt entry for VN1R4 Gene

Proteomics data for VN1R4 Gene at MOPED

Post-translational modifications for VN1R4 Gene

  • Glycosylation at Asn 154 and Asn 157
  • Modification sites at PhosphoSitePlus

Other Protein References for VN1R4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R4 Gene

Domains & Families for VN1R4 Gene

Gene Families for VN1R4 Gene

HGNC:

Protein Domains for VN1R4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for VN1R4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5H5

UniProtKB/Swiss-Prot:

VN1R4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with VN1R4: view

Function for VN1R4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for VN1R4 Gene

UniProtKB/Swiss-Prot Function:
Putative pheromone receptor.

Phenotypes for VN1R4 Gene

GenomeRNAi human phenotypes for VN1R4:
genes like me logo Genes that share phenotypes with VN1R4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VN1R4 Gene

Localization for VN1R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VN1R4 Gene COMPARTMENTS Subcellular localization image for VN1R4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for VN1R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with VN1R4: view

Pathways & Interactions for VN1R4 Gene

SuperPathways for VN1R4 Gene

PathCards logoMore details on SuperPathways for VN1R4
No Data Available

Interacting Proteins for VN1R4 Gene

Gene Ontology (GO) - Biological Process for VN1R4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VN1R4 Gene

Drugs & Compounds for VN1R4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for VN1R4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for VN1R4 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R4 Gene

No ASD Table

Relevant External Links for VN1R4 Gene

GeneLoc Exon Structure for
VN1R4
ECgene alternative splicing isoforms for
VN1R4

Expression for VN1R4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for VN1R4 Gene

mRNA expression in normal human tissues for VN1R4 Gene
mRNA expression by BioGPS for VN1R4 GenemRNA expression by GTEx for VN1R4 Gene

mRNA differential expression in normal tissues according to GTEx for VN1R4 Gene

This gene is overexpressed in Testis (x48.0) and Cervix - Endocervix (x5.0).

SOURCE GeneReport for Unigene cluster for VN1R4 Gene Hs.553685

genes like me logo Genes that share expression patterns with VN1R4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for VN1R4 Gene

Orthologs for VN1R4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VN1R4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia BOSTAUV1R416 35
  • 74.09 (n)
  • 61.79 (a)
VN1R4 36
  • 62 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia VN1R4 35
  • 71.44 (n)
  • 55.33 (a)
VN1R4 36
  • 50 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Vmn1r237 35
  • 66.55 (n)
  • 54.32 (a)
Vmn1r237 16
Vmn1r233 36
  • 42 (a)
 OneToMany
Vmn1r234 36
  • 45 (a)
 OneToMany
Vmn1r235 36
  • 42 (a)
 OneToMany
Vmn1r236 36
  • 43 (a)
 OneToMany
chimpanzee
(Pan troglodytes)
 Mammalia VN1R4 35
  • 71.92 (n)
  • 56.51 (a)
rat
(Rattus norvegicus)
 Mammalia Vom1r21 35
  • 66.32 (n)
  • 49.13 (a)
Species with no ortholog for VN1R4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VN1R4 Gene

ENSEMBL:
Gene Tree for VN1R4 (if available)
TreeFam:
Gene Tree for VN1R4 (if available)

Paralogs for VN1R4 Gene

Paralogs for VN1R4 Gene

(5) SIMAP similar genes for VN1R4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for VN1R4 Gene

genes like me logo Genes that share paralogs with VN1R4: view

Variants for VN1R4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R4 Gene

VN1R4_HUMAN-Q7Z5H5
Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.

Sequence variations from dbSNP and Humsavar for VN1R4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_022799 -
VAR_022800 -
rs12977715 - 53,267,008(+) GAGAT(C/T)GCTCC reference, missense
rs16984664 -- 53,266,608(+) TTGGG(A/G)TGGAA downstream-variant-500B
rs71185857 -- 53,268,168(-) GTGTA(-/TGTG)TGTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VN1R4 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV Deletion 23290073
nsv912342 CNV Gain 21882294
esv2718812 CNV Deletion 23290073

Variation tolerance for VN1R4 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for VN1R4 Gene

Disorders for VN1R4 Gene

Relevant External Links for VN1R4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VN1R4

No disorders were found for VN1R4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R4 Gene

Publications for VN1R4 Gene

  1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PMID: 12123587) Rodriguez I. … Mombaerts P. (Curr. Biol. 2002) 2 3 4 67
  2. Extreme variability among mammalian V1R gene families. (PMID: 19952141) Young J.M. … Trask B.J. (Genome Res. 2010) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J. … Webb D.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3

Products for VN1R4 Gene

Sources for VN1R4 Gene

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