Aliases for VN1R4 Gene
Aliases for VN1R4 Gene
External Ids for VN1R4 Gene
- HGNC: 19871
- Entrez Gene: 317703
- Ensembl: ENSG00000228567
- UniProtKB: Q7Z5H5
Previous GeneCards Identifiers for VN1R4 Gene
- GC19M054131
- GC19M058446
- GC19M058461
- GC19M053770
- GC19M050090
Summaries for VN1R4 Gene
GeneCards Summary for VN1R4 Gene
VN1R4 (Vomeronasal 1 Receptor 4) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and pheromone receptor activity. An important paralog of this gene is VN1R2.
UniProtKB/Swiss-Prot for VN1R4 Gene
-
Putative pheromone receptor.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R4 Gene
Genomics for VN1R4 Gene
Regulatory Elements for VN1R4 Gene
Enhancers for VN1R4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19F053977 | 1.1 | ENCODE | 16.2 | -712.1 | -712055 | 5.8 | PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 ZNF143 ZNF263 SP3 NFYC REST | PRPF31 ZNF347 ZNF665 ERVV-2 CACNG8 CDC42EP5 MIR519A2 BIRC8 FAM90A28P ENSG00000269758 |
| GH19F053878 | 1 | ENCODE | 16.2 | -611.6 | -611603 | 1.4 | CREB3L1 ARID4B GLI4 ZNF48 ZNF2 ETS1 SLC30A9 ELK1 ZNF143 SP3 | ERVV-2 CDC42EP5 MIR519A2 VN1R4 BIRC8 FAM90A28P VN1R6P ENSG00000269758 LOC204800 ZNF765 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around VN1R4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the VN1R4 gene promoter:
Regulatory Element Products
Genomic Location for VN1R4 Gene
- Chromosome:
- 19
- Start:
- 53,266,676 bp from pter
- End:
- 53,267,907 bp from pter
- Size:
- 1,232 bases
- Orientation:
- Minus strand
Genomic View for VN1R4 Gene
Genes around VN1R4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.42 by Ensembl
- 19q13.42 by Entrez Gene
- 19q13.42 by HGNC
VN1R4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VN1R4 Gene
Proteins for VN1R4 Gene
-
Protein details for VN1R4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z5H5-VN1R4_HUMAN
- Recommended name:
- Vomeronasal type-1 receptor 4
- Protein Accession:
- Q7Z5H5
- Q2M3E2
- Q7Z5H6
- Q7Z5H7
- Q8TDU2
Protein attributes for VN1R4 Gene
- Size:
- 301 amino acids
- Molecular mass:
- 33557 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.
Post-translational modifications for VN1R4 Gene
Other Protein References for VN1R4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for VN1R4
-
Abcam antibodies for VN1R4
- Invitrogen Antibodies for VN1R4
- antibodies-online Antibodies for VN1R4: See all 36
- GeneTex VN1R4 antibody for VN1R4
-
St John's Laboratory Antibodies for VN1R4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VN1R4
- Origene Custom Protein Services for VN1R4
- Novus Biologicals proteins for VN1R4
- Search GeneTex for Proteins for VN1R4
Assay Products
No data available for DME Specific Peptides for VN1R4 Gene
Domains & Families for VN1R4 Gene
Gene Families for VN1R4 Gene
Protein Domains for VN1R4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VN1R4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z5H5- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for VN1R4 Gene
Molecular function for VN1R4 Gene
- UniProtKB/Swiss-Prot Function:
- Putative pheromone receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0016503 | pheromone receptor activity | IEA | -- |
Phenotypes for VN1R4 Gene
- GenomeRNAi human phenotypes for VN1R4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VN1R4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VN1R4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VN1R4 gene
- Search ViGene Biosciences for VN1R4
CRISPR Products
-
OriGene CRISPR knockouts for VN1R4
- GenScript: Design CRISPR guide RNA sequences for VN1R4
miRNA Products
- Search ViGene Biosciences for VN1R4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for VN1R4
- Browse OriGene Inhibitory RNA Products For VN1R4
-
ViGene Biosciences ready-to-package AAV shRNAs for VN1R4 gene
Clone Products
-
OriGene ORF clones in human for VN1R4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VN1R4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VN1R4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for VN1R4
-
ViGene Biosciences adenoviral particle packaged cDNA for VN1R4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VN1R4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VN1R4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VN1R4 Gene
Localization for VN1R4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VN1R4 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for VN1R4 Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0019236 | response to pheromone | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for VN1R4 Gene
Transcripts for VN1R4 Gene
mRNA/cDNA for VN1R4 Gene
- (5) REFSEQ mRNAs :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for VN1R4
- GenScript: Design CRISPR guide RNA sequences for VN1R4
miRNA Products
- Search ViGene Biosciences for VN1R4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for VN1R4
- Browse OriGene Inhibitory RNA Products For VN1R4
-
ViGene Biosciences ready-to-package AAV shRNAs for VN1R4 gene
Clone Products
-
OriGene ORF clones in human for VN1R4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VN1R4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VN1R4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for VN1R4 Gene
mRNA differential expression in normal tissues according to GTEx for VN1R4 Gene
This gene is overexpressed in Testis (x48.0) and Cervix - Endocervix (x5.0).
NURSA nuclear receptor signaling pathways regulating expression of VN1R4 Gene:
VN1R4SOURCE GeneReport for Unigene cluster for VN1R4 Gene:
Hs.553685Primer Products
-
OriGene qPCR primer pairs for VN1R4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for VN1R4 Gene
Orthologs for VN1R4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | BOSTAUV1R416 34 |
|
||
| VN1R4 35 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | VN1R4 34 |
|
||
| dog (Canis familiaris) |
Mammalia | VN1R4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Vmn1r237 34 16 |
|
||
| Vmn1r234 35 |
|
OneToMany | |||
| Vmn1r236 35 |
|
OneToMany | |||
| Vmn1r233 35 |
|
OneToMany | |||
| Vmn1r235 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Vom1r21 34 |
|
- Species where no ortholog for VN1R4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for VN1R4 Gene
(5) SIMAP similar genes for VN1R4 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for VN1R4 Gene
- PGOHUM00000291746
- PGOHUM00000292689
- PGOHUM00000293517
- PGOHUM00000293518
- PGOHUM00000293567
- PGOHUM00000293780
- PGOHUM00000293781
- PGOHUM00000293830
- PGOHUM00000293843
- PGOHUM00000294666
- PGOHUM00000294914
- PGOHUM00000294942
- PGOHUM00000295257
- PGOHUM00000295271
- PGOHUM00000295273
- PGOHUM00000295315
- PGOHUM00000295398
- PGOHUM00000295442
- PGOHUM00000296858
- PGOHUM00000297075
- PGOHUM00000297327
- PGOHUM00000297441
- PGOHUM00000298429
- PGOHUM00000298953
- PGOHUM00000299355
- PGOHUM00000300314
- PGOHUM00000301697
- PGOHUM00000302205
- PGOHUM00000302224
- PGOHUM00000302233
- PGOHUM00000302235
- PGOHUM00000302247
- PGOHUM00000302248
- PGOHUM00000302250
- PGOHUM00000302655
- PGOHUM00000302693
- PGOHUM00000303176
- PGOHUM00000306656
- PGOHUM00000287921
- PGOHUM00000306748
- PGOHUM00000306763
Variants for VN1R4 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R4 Gene
- VN1R4_HUMAN-Q7Z5H5
- Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10404699 | -- | 53,264,865(+) | AAGTG(G/T)AAAGA | intron-variant | |
| rs10412309 | -- | 53,266,488(+) | ATTGC(A/G)TAGAC | intron-variant, downstream-variant-500B | |
| rs10419275 | -- | 53,268,708(+) | GTAAA(A/C/T)GGAAA | intron-variant, upstream-variant-2KB | |
| rs10419780 | -- | 53,269,025(+) | AGTCA(A/G)TCTAT | intron-variant, upstream-variant-2KB | |
| rs10421203 | -- | 53,269,430(+) | ttctc(A/G)cagag | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1141887 | OTHER | inversion | 24896259 |
| nsv1078889 | OTHER | inversion | 25765185 |
| nsv1055773 | CNV | gain | 25217958 |
| nsv1055236 | CNV | gain | 25217958 |
| esv3644741 | CNV | gain | 21293372 |
| esv2718812 | CNV | deletion | 23290073 |
| esv2718787 | CNV | deletion | 23290073 |
Residual Variation Intolerance Score:
74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.54;
44.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for VN1R4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VN1R4
Disorders for VN1R4 Gene
Relevant External Links for VN1R4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- VN1R4
No disorders were found for VN1R4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R4 Gene
Publications for VN1R4 Gene
- Novel human vomeronasal receptor-like genes reveal species-specific families. (PMID: 12123587) Rodriguez I. … Mombaerts P. (Curr. Biol. 2002) 2 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J. … Webb D.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
- Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 64
- Extreme variability among mammalian V1R gene families. (PMID: 19952141) Young J.M. … Trask B.J. (Genome Res. 2010) 3 64
Products for VN1R4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for VN1R4
- Browse OriGene Inhibitory RNA Products For VN1R4
- OriGene qPCR primer pairs for VN1R4
- OriGene CRISPR knockouts for VN1R4
- OriGene ORF clones in human for VN1R4
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- Novus Biologicals Antibodies for VN1R4
- Novus Biologicals proteins for VN1R4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for VN1R4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for VN1R4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for VN1R4 gene
- Search ViGene Biosciences for VN1R4
- Horizon Cell Lines for VN1R4
- Cyagen custom Knockout/knockin (KOKI) mouse models for VN1R4
- VectorBuilder custom plasmid, inducible vectors for VN1R4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VN1R4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for VN1R4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
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- (100) COMPARTMENTS
- (101) HOMER
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- (104) Addgene
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- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab