Aliases for VN1R4 Gene
Aliases for VN1R4 Gene
External Ids for VN1R4 Gene
- HGNC: 19871
- Entrez Gene: 317703
- Ensembl: ENSG00000228567
- UniProtKB: Q7Z5H5
Previous GeneCards Identifiers for VN1R4 Gene
- GC19M054131
- GC19M058446
- GC19M058461
- GC19M053770
- GC19M050090
Summaries for VN1R4 Gene
GeneCards Summary for VN1R4 Gene
VN1R4 (Vomeronasal 1 Receptor 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and pheromone receptor activity. An important paralog of this gene is VN1R2.
UniProtKB/Swiss-Prot for VN1R4 Gene
-
Putative pheromone receptor.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R4 Gene
Genomics for VN1R4 Gene
GeneHancer (GH) Regulatory Elements for VN1R4 Gene
Regulatory Element Products
Genomic Locations for VN1R4 Gene
Genomic Locations for VN1R4 Gene
- chr19:53,266,676-53,267,907
- (GRCh38/hg38)
- Size:
- 1,232 bases
- Orientation:
- Minus strand
- chr19:53,769,929-53,770,972
- (GRCh37/hg19)
Genomic View for VN1R4 Gene
Genes around VN1R4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.42 by Ensembl
- 19q13.42 by Entrez Gene
- 19q13.42 by HGNC
VN1R4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for VN1R4 Gene
Proteins for VN1R4 Gene
-
Protein details for VN1R4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z5H5-VN1R4_HUMAN
- Recommended name:
- Vomeronasal type-1 receptor 4
- Protein Accession:
- Q7Z5H5
- Q2M3E2
- Q7Z5H6
- Q7Z5H7
- Q8TDU2
Protein attributes for VN1R4 Gene
- Size:
- 301 amino acids
- Molecular mass:
- 33557 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- The chimpanzee and gorilla orthologous proteins do not exist, their genes are pseudogenes.
Post-translational modifications for VN1R4 Gene
- Glycosylation at posLast=154154 and posLast=157157
Other Protein References for VN1R4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for VN1R4
- Invitrogen Antibodies for VN1R4
- Search GeneTex for Antibodies for VN1R4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for VN1R4
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- Novus Biologicals proteins for VN1R4
- Search GeneTex for Proteins for VN1R4
Assay Products
No data available for DME Specific Peptides for VN1R4 Gene
Domains & Families for VN1R4 Gene
Gene Families for VN1R4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for VN1R4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VN1R4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z5H5- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for VN1R4 Gene
Molecular function for VN1R4 Gene
- UniProtKB/Swiss-Prot Function:
- Putative pheromone receptor.
Phenotypes From GWAS Catalog for VN1R4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G-protein coupled receptor activity | IEA | -- |
GO:0016503 | pheromone receptor activity | IEA | -- |
Phenotypes for VN1R4 Gene
- GenomeRNAi human phenotypes for VN1R4:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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- Overview of 80 available VN1R4 gene related products
- Applied Biological Materials CRISPR for VN1R4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VN1R4
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miRNA Products
- Search ViGene Biosciences for VN1R4
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 80 available VN1R4 gene related products
- Overview of 80 available VN1R4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VN1R4 gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for VN1R4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for VN1R4
-
ViGene Biosciences adenoviral particle packaged cDNA for VN1R4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VN1R4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VN1R4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VN1R4 Gene
Localization for VN1R4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for VN1R4 Gene
- Cell membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for VN1R4 Gene
Pathways & Interactions for VN1R4 Gene
No Data Available
Interacting Proteins for VN1R4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
GO:0007606 | sensory perception of chemical stimulus | IBA | -- |
GO:0019236 | response to pheromone | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for VN1R4 Gene
Transcripts for VN1R4 Gene
mRNA/cDNA for VN1R4 Gene
- (5) REFSEQ mRNAs :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for VN1R4
- genomics-online: gRNA clones - Search results for 80 available VN1R4 gene related products
- Overview of 80 available VN1R4 gene related products
- Applied Biological Materials CRISPR for VN1R4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VN1R4
- GenScript: Design CRISPR guide RNA sequences for VN1R4
miRNA Products
- Search ViGene Biosciences for VN1R4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for VN1R4
- Browse OriGene Inhibitory RNA Products For VN1R4
- genomics-online: shRNA clones - Search results for 80 available VN1R4 gene related products
- Overview of 80 available VN1R4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VN1R4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VN1R4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VN1R4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for VN1R4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for VN1R4 Gene
mRNA differential expression in normal tissues according to GTEx for VN1R4 Gene
This gene is overexpressed in Testis (x48.0) and Cervix - Endocervix (x5.0).
NURSA nuclear receptor signaling pathways regulating expression of VN1R4 Gene:
VN1R4SOURCE GeneReport for Unigene cluster for VN1R4 Gene:
Hs.553685Primer Products
-
OriGene qPCR primer pairs for VN1R4
- genomics-online: primer clones - Search results for 80 available VN1R4 gene related products
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VN1R4 Gene
Orthologs for VN1R4 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
cow (Bos Taurus) |
Mammalia | BOSTAUV1R416 33 |
|
||
VN1R4 34 |
|
OneToOne | |||
chimpanzee (Pan troglodytes) |
Mammalia | VN1R4 33 |
|
||
dog (Canis familiaris) |
Mammalia | VN1R4 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Vmn1r237 16 33 |
|
||
Vmn1r234 34 |
|
OneToMany | |||
Vmn1r236 34 |
|
OneToMany | |||
Vmn1r235 34 |
|
OneToMany | |||
Vmn1r233 34 |
|
OneToMany | |||
rat (Rattus norvegicus) |
Mammalia | Vom1r21 33 |
|
- Species where no ortholog for VN1R4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for VN1R4 Gene
(5) SIMAP similar genes for VN1R4 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for VN1R4 Gene
- PGOHUM00000291746
- PGOHUM00000292689
- PGOHUM00000293517
- PGOHUM00000293518
- PGOHUM00000293567
- PGOHUM00000293780
- PGOHUM00000293781
- PGOHUM00000293830
- PGOHUM00000293843
- PGOHUM00000294666
- PGOHUM00000294914
- PGOHUM00000294942
- PGOHUM00000295257
- PGOHUM00000295271
- PGOHUM00000295273
- PGOHUM00000295315
- PGOHUM00000295398
- PGOHUM00000295442
- PGOHUM00000296858
- PGOHUM00000297075
- PGOHUM00000297327
- PGOHUM00000297441
- PGOHUM00000298429
- PGOHUM00000298953
- PGOHUM00000299355
- PGOHUM00000300314
- PGOHUM00000301697
- PGOHUM00000302205
- PGOHUM00000302224
- PGOHUM00000302233
- PGOHUM00000302235
- PGOHUM00000302247
- PGOHUM00000302248
- PGOHUM00000302250
- PGOHUM00000302655
- PGOHUM00000302693
- PGOHUM00000303176
- PGOHUM00000306656
- PGOHUM00000287921
- PGOHUM00000306748
- PGOHUM00000306763
Variants for VN1R4 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R4 Gene
- VN1R4_HUMAN-Q7Z5H5
- Various VN1R4 alleles are known. The sequence shown is that of allele VN1R4*1.
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000329451 | -- | 53,272,122(-) | C/T | upstream_transcript_variant | |
rs1000488478 | -- | 53,268,230(-) | A/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000736958 | -- | 53,264,195(-) | C/T | downstream_transcript_variant | |
rs1000860261 | -- | 53,269,283(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1001176929 | -- | 53,265,337(-) | G/A | genic_downstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2718787 | CNV | deletion | 23290073 |
esv2718812 | CNV | deletion | 23290073 |
esv3644741 | CNV | gain | 21293372 |
nsv1055236 | CNV | gain | 25217958 |
nsv1055773 | CNV | gain | 25217958 |
nsv1078889 | OTHER | inversion | 25765185 |
nsv1141887 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.54;
44.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VN1R4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- VN1R4
Disorders for VN1R4 Gene
Additional Disease Information for VN1R4
No disorders were found for VN1R4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R4 Gene
Publications for VN1R4 Gene
- Novel human vomeronasal receptor-like genes reveal species-specific families. (PMID: 12123587) Rodriguez I … Mombaerts P (Current biology : CB 2002) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J … Webb DM (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
- Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
- Extreme variability among mammalian V1R gene families. (PMID: 19952141) Young JM … Trask BJ (Genome research 2010) 3 58
Products for VN1R4 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 35 available VN1R4 Antibodies ranked by validation data
- Compare Top VN1R4 Antibodies
- antibodies-online: Search results for available VN1R4 related products ranked by validation data
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Sources for VN1R4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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- (145) dbSUPER
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- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
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- (155) genomics-online
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- (157) EPDnew