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VN1R3 Gene

pseudogene   GIFtS: 33
GCID: GC16M031818

Vomeronasal 1 Receptor 3 (Gene/Pseudogene)

(Previous names: vomeronasal 1 receptor 3, vomeronasal 1 receptor 3 pseudogene)
  Search for VN1R3
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Vomeronasal 1 Receptor 3 (Gene/Pseudogene)1 2
V1RL32 3
Vomeronasal 1 Receptor 31
Vomeronasal 1 Receptor 3 Pseudogene1
V1RL3p2
V1r-Like Receptor 33

External Ids:    HGNC: 198671   Entrez Gene: 3177022   Ensembl: ENSG000001806637   UniProtKB: Q9BXE93   
ORGUL members:         

Export aliases for VN1R3 gene to outside databases

Previous GC identifers: GC16M032315 GC16M031815 GC16M031855 GC16M031856 GC16M031726 GC16M029379


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for VN1R3 Gene:
VN1R3 (vomeronasal 1 receptor 3 (gene/pseudogene)) is a pseudogene, and is affiliated with the lncRNA class. GO annotations related to this gene include pheromone receptor activity.

UniProtKB/Swiss-Prot: VN1R3_HUMAN, Q9BXE9
Function: Putative pheromone receptor

Gene Wiki entry for VN1R3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for VN1R3
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VN1R3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

VN1R3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VN1R3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M031818:  view genomic region     (about GC identifiers)

Start:
31,818,911 bp from pter      End:
31,820,167 bp from pter
Size:
1,257 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VN1R3_HUMAN, Q9BXE9 (See protein sequence)
Recommended Name: Vomeronasal type-1 receptor 3  
Size: 311 amino acids; 34713 Da
Miscellaneous: The gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes

Explore the universe of human proteins at neXtProt for VN1R3: NX_Q9BXE9

Post-translational modifications: 

  • Glycosylation2 at Asn159

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VN1R: Vomeronasal receptors / Type 1
    VN1RU: GPCR / Unclassified : Vomeronasal receptors, type 1

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004072 Vmron_rcpt_1

    Graphical View of Domain Structure for InterPro Entry Q9BXE9

    ProtoNet protein and cluster: Q9BXE9

    1 Blocks protein domain: IPB004072 Vomeronasal type 1 receptor family signature

    UniProtKB/Swiss-Prot: VN1R3_HUMAN, Q9BXE9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    VN1R3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VN1R3_HUMAN, Q9BXE9
    Function: Putative pheromone receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016503pheromone receptor activity IEA--
         
    VN1R3 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VN1R3_HUMAN, Q9BXE9: Cell membrane; Multi-pass membrane protein

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    VN1R3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

        Search GeneGlobe Interaction Network for VN1R3

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019236response to pheromone IEA--

    VN1R3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    Unigene Cluster for VN1R3:

    Vomeronasal 1 receptor 3 (gene/pseudogene)
    Hs.257746  [show with all ESTs]
    Unigene Representative Sequence: AF336873
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418822(uc002ecr.3) ENST00000316512
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    Additional mRNA sequence: 

    AF336873.1 BC107073.1 BC107074.1 

    1 DOTS entry:

    DT.99944779 

    2 AceView cDNA sequences:

    NM_174980 AF336873 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VN1R3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCGCCATC
    VN1R3 Expression
    About this image

    VN1R3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.257746
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for VN1R3 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vmn1r2355 vomeronasal 1 receptor 235   --   17 (11.40 cM) 21260427 


    ENSEMBL Gene Tree for VN1R3 (if available)
    TreeFam Gene Tree for VN1R3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VN1R3 gene
    6 SIMAP similar genes for VN1R3 using alignment to 1 protein entry:     VN1R3_HUMAN:
    VN1R2    VN1R4    VN1R1    VN1R17P    FKSG47    FKSG83

    VN1R3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    VN1R3_HUMAN, Q9BXE9: There seems to be a deletion in the gene coding for this protein in about 98% of the population

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VN1R3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with VN1R3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PubMed id 12826614)1, 2 Zhang J. and Webb D.M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Novel human vomeronasal receptor-like genes reveal species-specific families. (PubMed id 12123587)1, 2 Rodriguez I. and Mombaerts P. (Curr. Biol. 2002)
    3. Extreme variability among mammalian V1R gene families. (PubMed id 19952141)1 Young J.M....Trask B.J. (Genome Res. 2010)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 317702 HGNC: 19867 AceView: VN1R3 Ensembl:ENSG00000180663 euGenes: HUgn317702
    ECgene: VN1R3 H-InvDB: VN1R3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VN1R3 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/061

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VN1R3 gene:
    Search GeneIP for patents involving VN1R3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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