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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VN1R2 Gene

protein-coding   GIFtS: 42
GCID: GC19P053760

Vomeronasal 1 Receptor 2

  Search for VN1R2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vomeronasal 1 Receptor 21 2     V1r-Like Receptor 22 3
V1RL22 3     Pheromone Receptor2
G-Protein Coupled Receptor GPCR252 3     V1R-Like 22
hGPCR252 3     Vomeronasal Type-1 Receptor 22

External Ids:    HGNC: 198721   Entrez Gene: 3177012   Ensembl: ENSG000001961317   UniProtKB: Q8NFZ63   

Export aliases for VN1R2 gene to outside databases

Previous GC identifers: GC19M054122 GC19P058437 GC19P058454 GC19P058455 GC19P058457 GC19P050082


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for VN1R2 Gene: 
VN1R2 (vomeronasal 1 receptor 2) is a protein-coding gene. GO annotations related to this gene include pheromone receptor activity. An important paralog of this gene is VN1R1.

UniProtKB/Swiss-Prot: VN1R2_HUMAN, Q8NFZ6
Function: Putative pheromone receptor

Gene Wiki entry for VN1R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VN1R2 gene promoter:
         Pax-4a   Ik-3   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for VN1R2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VN1R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

VN1R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VN1R2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P053760:  view genomic region     (about GC identifiers)

Start:
53,761,545 bp from pter      End:
53,765,090 bp from pter
Size:
3,546 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VN1R2_HUMAN, Q8NFZ6 (See protein sequence)
Recommended Name: Vomeronasal type-1 receptor 2  
Size: 395 amino acids; 44476 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are
pseudogenes
Secondary accessions: A1L411 Q8TDU4

Explore the universe of human proteins at neXtProt for VN1R2: NX_Q8NFZ6

Explore proteomics data for VN1R2 at MOPED 

VN1R2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

VN1R2 Protein Expression

REFSEQ proteins: NP_776255.2  
ENSEMBL proteins: 
 ENSP00000351244  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

VN1R2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
VN1R: Vomeronasal receptors / Type 1
VN1RU: GPCR / Unclassified : Vomeronasal receptors, type 1

2 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR004072 Vmron_rcpt_1

Graphical View of Domain Structure for InterPro Entry Q8NFZ6

ProtoNet protein and cluster: Q8NFZ6

1 Blocks protein domain: IPB004072 Vomeronasal type 1 receptor family signature

UniProtKB/Swiss-Prot: VN1R2_HUMAN, Q8NFZ6
Similarity: Belongs to the G-protein coupled receptor 1 family


VN1R2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: VN1R2_HUMAN, Q8NFZ6
Function: Putative pheromone receptor

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity ----
GO:0016503pheromone receptor activity IEA--
     
VN1R2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for VN1R2:
 Increased gamma-H2AX phosphory 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VN1R2

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0019236response to pheromone IEA--
GO:0050909sensory perception of taste ----

VN1R2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for VN1R2

Search CenterWatch for drugs/clinical trials and news about VN1R2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VN1R2 gene: 
NM_173856.2  

Unigene Cluster for VN1R2:

Vomeronasal 1 receptor 2
Hs.553684
Unigene Representative Sequence: NM_173856
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000341702(uc002qbi.2) ENST00000598458
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Additional mRNA sequence: 

BC130356.1 BC130358.1 

1 DOTS entry:

DT.99953630 

1 AceView cDNA sequence:

NM_173856 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VN1R2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTTCAGGAA
VN1R2 Expression
About this image


See VN1R2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VN1R2

SOURCE GeneReport for Unigene cluster: Hs.553684
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for VN1R2 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Vmn1r2241 , 5 vomeronasal 1 receptor 2241, 5 63.13(n)1
49.82(a)1
  17 (11.40 cM)5
6655251  NM_001166735.11  NP_001160207.11 
 204191635 


ENSEMBL Gene Tree for VN1R2 (if available)
TreeFam Gene Tree for VN1R2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for VN1R2 gene
VN1R12  VN1R42  
5 SIMAP similar genes for VN1R2 using alignment to 1 protein entry:     VN1R2_HUMAN:
VN1R4    VN1R3    VN1R1    FKSG41    FKSG47

VN1R2 for paralogs           About GeneDecksing


5/19 Pseudogenes.org Pseudogenes for VN1R2 (see all 19)
PGOHUM00000258810 PGOHUM00000258812 PGOHUM00000249059 PGOHUM00000259250 PGOHUM00000234883


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/122 SNPs in VN1R2 are shown (see all 122)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1404867741,2
--53760357(+) ATGTAG/TATATA 1 -- us2k10--------
rs1504217051,2
--53760361(+) ATATAC/TATGTG 1 -- us2k10--------
rs1926432421,2
--53760449(+) ACTCAC/TGTTCA 1 -- us2k10--------
rs1846260471,2
--53760514(+) TCTTTC/TAGAGT 1 -- us2k10--------
rs1891255141,2
--53760607(+) TCACTC/TATACA 1 -- us2k10--------
rs1815375991,2
--53760610(+) CTCATA/GCATTG 1 -- us2k10--------
rs1452552171,2
C--53760675(+) TCTATA/GTATTT 1 -- us2k10--------
rs1868240551,2
C,F--53760754(+) CAACTC/TGTGTT 1 -- us2k11Minor allele frequency- T:0.01EU 593
rs173050591,2
C,F,H--53760758(+) TCGTGT/GTGCCA 1 -- us2k115Minor allele frequency- G:0.16NA NS EA EU 1877
rs29143701,2
C,F,O,A,H--53760825(-) TTCAGA/GTCCAC 1 -- us2k133Minor allele frequency- N:0.00NS EA NA WA CSA EU 3579

HapMap Linkage Disequilibrium report for VN1R2 (53761545 - 53765090 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for VN1R2:    About this table     
Variant IDTypeSubtypePubMed ID
esv2718787CNV Deletion23290073
esv2718812CNV Deletion23290073
nsv912342CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for VN1R2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with VN1R2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PubMed id 12123587)1, 2, 3 Rodriguez I. and Mombaerts P. (2002)
  2. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PubMed id 12826614)1, 2 Zhang J. and Webb D.M. (2003)
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
  4. Extreme variability among mammalian V1R gene families . (PubMed id 19952141)1 Young J.M....Trask B.J. (2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 317701 HGNC: 19872 AceView: VN1R2 Ensembl:ENSG00000196131 euGenes: HUgn317701
ECgene: VN1R2 H-InvDB: VN1R2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for VN1R2 Pharmacogenomics, SNPs, Pathways
Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt061.shtml

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for VN1R2 gene:
Search GeneIP for patents involving VN1R2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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