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Aliases for VN1R2 Gene

Aliases for VN1R2 Gene

  • Vomeronasal 1 Receptor 2 2 3
  • G-Protein Coupled Receptor GPCR25 3 4
  • V1r-Like Receptor 2 3 4
  • HGPCR25 3 4
  • V1RL2 3 4
  • Vomeronasal Type-1 Receptor 2 3
  • Pheromone Receptor 3
  • V1R-Like 2 3

External Ids for VN1R2 Gene

Previous GeneCards Identifiers for VN1R2 Gene

  • GC19M054122
  • GC19P058437
  • GC19P058454
  • GC19P058455
  • GC19P058457
  • GC19P053760
  • GC19P050082

Summaries for VN1R2 Gene

GeneCards Summary for VN1R2 Gene

VN1R2 (Vomeronasal 1 Receptor 2) is a Protein Coding gene. GO annotations related to this gene include pheromone receptor activity. An important paralog of this gene is VN1R4.

UniProtKB/Swiss-Prot for VN1R2 Gene

  • Putative pheromone receptor

Gene Wiki entry for VN1R2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R2 Gene

Genomics for VN1R2 Gene

Regulatory Elements for VN1R2 Gene

Transcription factor binding sites by QIAGEN in the VN1R2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VN1R2 Gene

Start:
53,258,292 bp from pter
End:
53,261,837 bp from pter
Size:
3,546 bases
Orientation:
Plus strand

Genomic View for VN1R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VN1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VN1R2 Gene

Proteins for VN1R2 Gene

  • Protein details for VN1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFZ6-VN1R2_HUMAN
    Recommended name:
    Vomeronasal type-1 receptor 2
    Protein Accession:
    Q8NFZ6
    Secondary Accessions:
    • A1L411
    • Q8TDU4

    Protein attributes for VN1R2 Gene

    Size:
    395 amino acids
    Molecular mass:
    44476 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The chimpanzee, gorilla and orangutan orthologous proteins do not exist, their genes are pseudogenes

neXtProt entry for VN1R2 Gene

Proteomics data for VN1R2 Gene at MOPED

Post-translational modifications for VN1R2 Gene

  • Glycosylation at Asn239 and Asn343

Other Protein References for VN1R2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R2 Gene

Domains for VN1R2 Gene

Gene Families for VN1R2 Gene

HGNC:
  • VN1RU :GPCR / Unclassified : Vomeronasal receptors, type 1
  • VN1R :Vomeronasal receptors / Type 1

Protein Domains for VN1R2 Gene

Suggested Antigen Peptide Sequences for VN1R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFZ6

UniProtKB/Swiss-Prot:

VN1R2_HUMAN :
  • Q8NFZ6
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with VN1R2: view

Function for VN1R2 Gene

Molecular function for VN1R2 Gene

UniProtKB/Swiss-Prot Function: Putative pheromone receptor

Gene Ontology (GO) - Molecular Function for VN1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0016503 pheromone receptor activity IEA --
genes like me logo Genes that share ontologies with VN1R2: view

Phenotypes for VN1R2 Gene

GenomeRNAi human phenotypes for VN1R2:
genes like me logo Genes that share phenotypes with VN1R2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VN1R2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VN1R2 Gene

Localization for VN1R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VN1R2 Gene COMPARTMENTS Subcellular localization image for VN1R2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for VN1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VN1R2: view

Pathways for VN1R2 Gene

SuperPathways for VN1R2 Gene

No Data Available

Interacting Proteins for VN1R2 Gene

Gene Ontology (GO) - Biological Process for VN1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0019236 response to pheromone IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with VN1R2: view

No data available for Pathways by source for VN1R2 Gene

Transcripts for VN1R2 Gene

mRNA/cDNA for VN1R2 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VN1R2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R2 Gene

No ASD Table

Relevant External Links for VN1R2 Gene

GeneLoc Exon Structure for
VN1R2
ECgene alternative splicing isoforms for
VN1R2

Expression for VN1R2 Gene

mRNA expression in normal human tissues for VN1R2 Gene

mRNA differential expression in normal tissues according to GTEx for VN1R2 Gene

This gene is overexpressed in Testis (19.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for VN1R2 Gene

SOURCE GeneReport for Unigene cluster for VN1R2 Gene Hs.553684

genes like me logo Genes that share expressions with VN1R2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for VN1R2 Gene

Orthologs for VN1R2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VN1R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VN1R2 35
  • 98.72 (n)
  • 96.81 (a)
VN1R2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100856009 35
  • 77.55 (n)
  • 63.54 (a)
mouse
(Mus musculus)
Mammalia Vmn1r224 35
  • 63.13 (n)
  • 49.82 (a)
Vmn1r224 16
Vmn1r237 36
  • 44 (a)
ManyToMany
Species with no ortholog for VN1R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VN1R2 Gene

ENSEMBL:
Gene Tree for VN1R2 (if available)
TreeFam:
Gene Tree for VN1R2 (if available)

Paralogs for VN1R2 Gene

Paralogs for VN1R2 Gene

Selected SIMAP similar genes for VN1R2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VN1R2: view

Variants for VN1R2 Gene

Sequence variations from dbSNP and Humsavar for VN1R2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1820750 -- 53,258,099(-) ggtgg(G/T)actga upstream-variant-2KB
rs1820751 -- 53,258,098(-) gtggt(A/C)ctgag upstream-variant-2KB
rs2914366 -- 53,260,042(-) AACAT(C/T)ATCAT downstream-variant-500B
rs2914367 -- 53,259,833(-) AGATG(C/T)TTTCA downstream-variant-500B
rs2914368 -- 53,258,218(-) atttt(A/G)ctact upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VN1R2 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV Deletion 23290073
nsv912342 CNV Gain 21882294
esv2718812 CNV Deletion 23290073

Relevant External Links for VN1R2 Gene

HapMap Linkage Disequilibrium report
VN1R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R2 Gene

Disorders for VN1R2 Gene

No disorders were found for VN1R2 Gene.

No data available for UniProtKB/Swiss-Prot for VN1R2 Gene

Publications for VN1R2 Gene

  1. Novel human vomeronasal receptor-like genes reveal species-specific families. (PMID: 12123587) Rodriguez I. … Mombaerts P. (Curr. Biol. 2002) 2 3 4
  2. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J. … Webb D.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  4. Extreme variability among mammalian V1R gene families. (PMID: 19952141) Young J.M. … Trask B.J. (Genome Res. 2010) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for VN1R2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate VN1R2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for VN1R2
    • Block miRNA regulation of VN1R2 using miScript Target Protectors

    Sources for VN1R2 Gene

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