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Aliases for VN1R1 Gene

Aliases for VN1R1 Gene

  • Vomeronasal 1 Receptor 1 2 3
  • Vomeronasal Olfactory Receptor, (Chromosome 19) Subtype I, Member 1 2 3
  • Vomeronasal Olfactory Receptor Chromosome 19 Subtype I Member 1 3 4
  • G-Protein Coupled Receptor GPCR24 3 4
  • V3r-Related Gene Protein 3 4
  • V1r-Like Receptor 1 3 4
  • VNR19I1 3 4
  • HGPCR24 3 4
  • V1RL1 3 4
  • V1R-Like 1 3
  • ZVNH1 3
  • ZVNR1 3

External Ids for VN1R1 Gene

Previous HGNC Symbols for VN1R1 Gene

  • VNR19I1

Previous GeneCards Identifiers for VN1R1 Gene

  • GC19M058408
  • GC19M062642
  • GC19M062658
  • GC19M057966
  • GC19M054279

Summaries for VN1R1 Gene

Entrez Gene Summary for VN1R1 Gene

  • Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for VN1R1 Gene

VN1R1 (Vomeronasal 1 Receptor 1) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and pheromone receptor activity. An important paralog of this gene is VN1R2.

UniProtKB/Swiss-Prot for VN1R1 Gene

  • Putative pheromone receptor

Gene Wiki entry for VN1R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R1 Gene

Genomics for VN1R1 Gene

Regulatory Elements for VN1R1 Gene

Genomic Location for VN1R1 Gene

Chromosome:
19
Start:
57,454,790 bp from pter
End:
57,457,142 bp from pter
Size:
2,353 bases
Orientation:
Minus strand

Genomic View for VN1R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for VN1R1 Gene

Proteins for VN1R1 Gene

  • Protein details for VN1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZP7-VN1R1_HUMAN
    Recommended name:
    Vomeronasal type-1 receptor 1
    Protein Accession:
    Q9GZP7
    Secondary Accessions:
    • B3KSV5
    • Q7Z5H8
    • Q7Z5H9

    Protein attributes for VN1R1 Gene

    Size:
    353 amino acids
    Molecular mass:
    40021 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes

neXtProt entry for VN1R1 Gene

Proteomics data for VN1R1 Gene at MOPED

Post-translational modifications for VN1R1 Gene

  • Glycosylation at Asn 117 and Asn 198
  • Modification sites at PhosphoSitePlus

Other Protein References for VN1R1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R1 Gene

Domains & Families for VN1R1 Gene

Gene Families for VN1R1 Gene

Protein Domains for VN1R1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VN1R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZP7

UniProtKB/Swiss-Prot:

VN1R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with VN1R1: view

Function for VN1R1 Gene

Molecular function for VN1R1 Gene

UniProtKB/Swiss-Prot Function:
Putative pheromone receptor

Gene Ontology (GO) - Molecular Function for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016503 pheromone receptor activity IEA --
genes like me logo Genes that share ontologies with VN1R1: view

Phenotypes for VN1R1 Gene

genes like me logo Genes that share phenotypes with VN1R1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VN1R1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for VN1R1 Gene

Localization for VN1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VN1R1 Gene COMPARTMENTS Subcellular localization image for VN1R1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VN1R1: view

Pathways & Interactions for VN1R1 Gene

SuperPathways for VN1R1 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with VN1R1: view

Pathways by source for VN1R1 Gene

1 BioSystems pathway for VN1R1 Gene

Interacting Proteins for VN1R1 Gene

Gene Ontology (GO) - Biological Process for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with VN1R1: view

No data available for SIGNOR curated interactions for VN1R1 Gene

Drugs & Compounds for VN1R1 Gene

No Compound Related Data Available

Transcripts for VN1R1 Gene

mRNA/cDNA for VN1R1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VN1R1 Gene

Vomeronasal 1 receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VN1R1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R1 Gene

No ASD Table

Relevant External Links for VN1R1 Gene

GeneLoc Exon Structure for
VN1R1
ECgene alternative splicing isoforms for
VN1R1

Expression for VN1R1 Gene

mRNA expression in normal human tissues for VN1R1 Gene

Protein differential expression in normal tissues from HIPED for VN1R1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VN1R1 Gene



SOURCE GeneReport for Unigene cluster for VN1R1 Gene Hs.677423

mRNA Expression by UniProt/SwissProt for VN1R1 Gene

Q9GZP7-VN1R1_HUMAN
Tissue specificity: Expressed in the olfactory mucosa, very low expression in brain, lung and kidney.
genes like me logo Genes that share expression patterns with VN1R1: view

Protein tissue co-expression partners for VN1R1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VN1R1 Gene

Orthologs for VN1R1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VN1R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VN1R1 35
  • 74.97 (n)
  • 62.14 (a)
VN1R1 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vom1r52 35
  • 62.58 (n)
  • 45.7 (a)
mouse
(Mus musculus)
Mammalia Vmn1r70 16
Vmn1r83 36
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
monDomV1R1221 36
  • 35 (a)
OneToMany
monDomV1R1223 36
  • 39 (a)
OneToMany
monDomV1R1224 36
  • 41 (a)
OneToMany
monDomV1R1225 36
  • 40 (a)
OneToMany
monDomV1R1228 36
  • 39 (a)
OneToMany
monDomV1R1230 36
  • 37 (a)
OneToMany
monDomV1R1231 36
  • 36 (a)
OneToMany
monDomV1R1232 36
  • 37 (a)
OneToMany
monDomV1R1233 36
  • 38 (a)
OneToMany
monDomV1R1234 36
  • 42 (a)
OneToMany
monDomV1R1235 36
  • 45 (a)
OneToMany
monDomV1R1236 36
  • 37 (a)
OneToMany
monDomV1R1238 36
  • 38 (a)
OneToMany
monDomV1R1239 36
  • 37 (a)
OneToMany
monDomV1R1242 36
  • 34 (a)
OneToMany
monDomV1R1243 36
  • 37 (a)
OneToMany
monDomV1R1244 36
  • 35 (a)
OneToMany
monDomV1R1245 36
  • 35 (a)
OneToMany
monDomV1R1246 36
  • 36 (a)
OneToMany
monDomV1R1254 36
  • 34 (a)
OneToMany
monDomV1R1256 36
  • 33 (a)
OneToMany
monDomV1R1257 36
  • 34 (a)
OneToMany
monDomV1R1258 36
  • 34 (a)
OneToMany
monDomV1R1259 36
  • 35 (a)
OneToMany
monDomV1R1260 36
  • 34 (a)
OneToMany
monDomV1R1261 36
  • 35 (a)
OneToMany
monDomV1R1263 36
  • 32 (a)
OneToMany
monDomV1R1266 36
  • 35 (a)
OneToMany
monDomV1R1267 36
  • 36 (a)
OneToMany
monDomV1R1268 36
  • 34 (a)
OneToMany
monDomV1R1270 36
  • 37 (a)
OneToMany
monDomV1R1271 36
  • 39 (a)
OneToMany
monDomV1R1272 36
  • 39 (a)
OneToMany
monDomV1R1280 36
  • 35 (a)
OneToMany
monDomV1R1281 36
  • 39 (a)
OneToMany
monDomV1R1282 36
  • 39 (a)
OneToMany
monDomV1R1283 36
  • 39 (a)
OneToMany
monDomV1R1290 36
  • 36 (a)
OneToMany
monDomV1R1292 36
  • 36 (a)
OneToMany
monDomV1R1294 36
  • 37 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia VN1R3 36
  • 47 (a)
OneToOne
Species with no ortholog for VN1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VN1R1 Gene

ENSEMBL:
Gene Tree for VN1R1 (if available)
TreeFam:
Gene Tree for VN1R1 (if available)

Paralogs for VN1R1 Gene

Paralogs for VN1R1 Gene

(3) SIMAP similar genes for VN1R1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with VN1R1: view

Variants for VN1R1 Gene

Sequence variations from dbSNP and Humsavar for VN1R1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3746223 - 57,456,178(-) GGGAT(A/G)CCTCA reference, missense
rs6510072 -- 57,458,609(+) TTTAT(C/T)TTCAA upstream-variant-2KB
rs7247474 -- 57,455,094(+) AAGCA(A/C)CTGAA downstream-variant-500B
rs8101158 -- 57,454,712(+) cccac(A/C)tcagc downstream-variant-500B
rs8109760 -- 57,457,182(+) GCCCT(C/T)CAGCC upstream-variant-2KB

Variation tolerance for VN1R1 Gene

Residual Variation Intolerance Score: 86.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VN1R1 Gene

HapMap Linkage Disequilibrium report
VN1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VN1R1 Gene

Disorders for VN1R1 Gene

Relevant External Links for VN1R1

Genetic Association Database (GAD)
VN1R1
Human Genome Epidemiology (HuGE) Navigator
VN1R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VN1R1
genes like me logo Genes that share disorders with VN1R1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R1 Gene

Publications for VN1R1 Gene

  1. Identification of V1R-like putative pheromone receptor sequences in non-human primates. Characterization of V1R pseudogenes in marmoset, a primate species that possesses an intact vomeronasal organ. (PMID: 12142329) Giorgi D. … Rouquier S. (Chem. Senses 2002) 23 67
  2. A putative pheromone receptor gene expressed in human olfactory mucosa. (PMID: 10973240) Rodriguez I. … Mombaerts P. (Nat. Genet. 2000) 2 67
  3. Structure and function analyses of the purified GPCR human vomeronasal type 1 receptor 1. (PMID: 22355687) Corin K. … Zhang S. (Sci Rep 2011) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. Extreme variability among mammalian V1R gene families. (PMID: 19952141) Young J.M. … Trask B.J. (Genome Res. 2010) 67

Products for VN1R1 Gene

Sources for VN1R1 Gene

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