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Aliases for VN1R1 Gene

Aliases for VN1R1 Gene

  • Vomeronasal 1 Receptor 1 2 3 5
  • Vomeronasal Olfactory Receptor, (Chromosome 19) Subtype I, Member 1 2 3
  • Vomeronasal Olfactory Receptor Chromosome 19 Subtype I Member 1 3 4
  • G-Protein Coupled Receptor GPCR24 3 4
  • V3r-Related Gene Protein 3 4
  • V1r-Like Receptor 1 3 4
  • VNR19I1 3 4
  • HGPCR24 3 4
  • V1RL1 3 4
  • Vomeronasal Type-1 Receptor 1 3
  • V1R-Like 1 3
  • ZVNH1 3
  • ZVNR1 3

External Ids for VN1R1 Gene

Previous HGNC Symbols for VN1R1 Gene

  • VNR19I1

Previous GeneCards Identifiers for VN1R1 Gene

  • GC19M058408
  • GC19M062642
  • GC19M062658
  • GC19M057966
  • GC19M054279

Summaries for VN1R1 Gene

Entrez Gene Summary for VN1R1 Gene

  • Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for VN1R1 Gene

VN1R1 (Vomeronasal 1 Receptor 1) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and pheromone receptor activity. An important paralog of this gene is VN1R4.

UniProtKB/Swiss-Prot for VN1R1 Gene

  • Putative pheromone receptor.

Gene Wiki entry for VN1R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VN1R1 Gene

Genomics for VN1R1 Gene

Regulatory Elements for VN1R1 Gene

Enhancers for VN1R1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F057476 1 ENCODE 29.5 -20.3 -20336 1.5 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 SLC30A9 VN1R1 ZNF773 ZNF417 ZNF606 ZSCAN22 ZNF550 ZNF324B ZNF587 ZNF837 ZNF17
GH19F057487 0.7 ENCODE 29.3 -30.9 -30902 1.9 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF48 ETS1 ZNF419 VN1R1 ZNF773 ZNF805 RPS5 ZNF550 ZNF544 A1BG-AS1 ENSG00000268107 GC19P057489
GH19F057526 0.9 ENCODE 21.2 -70.3 -70333 1.5 PKNOX1 ATF1 ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF48 ETS1 YY1 VN1R1 ZNF587 GC19M057527 ZNF549
GH19F057558 0.2 ENCODE 19.4 -102.5 -102513 2.5 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A GLI4 ZNF48 ETS1 YY1 ELK1 ZNF549 ZNF550 VN1R1 ZNF805 ZNF530 ZNF134 ZIK1 RPS5 ZNF749 PIR36667
GH19F057499 0.6 ENCODE 17.1 -43.1 -43080 1.9 HDGF PKNOX1 ATF1 ARID4B SIN3A YBX1 DMAP1 ZNF48 ZNF2 ETS1 ZNF419 VN1R1 ZNF773 ZNF549 ZNF772 ZNF550 ZNF749 LOC105372476 PIR62372
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around VN1R1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VN1R1 Gene

Chromosome:
19
Start:
57,454,790 bp from pter
End:
57,457,142 bp from pter
Size:
2,353 bases
Orientation:
Minus strand

Genomic View for VN1R1 Gene

Genes around VN1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VN1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VN1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VN1R1 Gene

Proteins for VN1R1 Gene

  • Protein details for VN1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZP7-VN1R1_HUMAN
    Recommended name:
    Vomeronasal type-1 receptor 1
    Protein Accession:
    Q9GZP7
    Secondary Accessions:
    • B3KSV5
    • Q7Z5H8
    • Q7Z5H9

    Protein attributes for VN1R1 Gene

    Size:
    353 amino acids
    Molecular mass:
    40021 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

neXtProt entry for VN1R1 Gene

Post-translational modifications for VN1R1 Gene

  • Glycosylation at Asn 117 and Asn 198
  • Modification sites at PhosphoSitePlus

Other Protein References for VN1R1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VN1R1 Gene

Domains & Families for VN1R1 Gene

Gene Families for VN1R1 Gene

Protein Domains for VN1R1 Gene

Suggested Antigen Peptide Sequences for VN1R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZP7

UniProtKB/Swiss-Prot:

VN1R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with VN1R1: view

Function for VN1R1 Gene

Molecular function for VN1R1 Gene

UniProtKB/Swiss-Prot Function:
Putative pheromone receptor.

Gene Ontology (GO) - Molecular Function for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0016503 pheromone receptor activity IEA --
genes like me logo Genes that share ontologies with VN1R1: view
genes like me logo Genes that share phenotypes with VN1R1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VN1R1 Gene

Localization for VN1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VN1R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VN1R1 Gene COMPARTMENTS Subcellular localization image for VN1R1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VN1R1: view

Pathways & Interactions for VN1R1 Gene

SuperPathways for VN1R1 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with VN1R1: view

Pathways by source for VN1R1 Gene

1 BioSystems pathway for VN1R1 Gene

Interacting Proteins for VN1R1 Gene

Gene Ontology (GO) - Biological Process for VN1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0019236 response to pheromone IEA --
genes like me logo Genes that share ontologies with VN1R1: view

No data available for SIGNOR curated interactions for VN1R1 Gene

Transcripts for VN1R1 Gene

mRNA/cDNA for VN1R1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VN1R1 Gene

Vomeronasal 1 receptor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VN1R1 Gene

No ASD Table

Relevant External Links for VN1R1 Gene

GeneLoc Exon Structure for
VN1R1
ECgene alternative splicing isoforms for
VN1R1

Expression for VN1R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VN1R1 Gene

Protein differential expression in normal tissues from HIPED for VN1R1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VN1R1 Gene



Protein tissue co-expression partners for VN1R1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VN1R1 Gene:

VN1R1

SOURCE GeneReport for Unigene cluster for VN1R1 Gene:

Hs.677423

mRNA Expression by UniProt/SwissProt for VN1R1 Gene:

Q9GZP7-VN1R1_HUMAN
Tissue specificity: Expressed in the olfactory mucosa, very low expression in brain, lung and kidney.
genes like me logo Genes that share expression patterns with VN1R1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for VN1R1 Gene

Orthologs for VN1R1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for VN1R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VN1R1 34 35
  • 74.97 (n)
rat
(Rattus norvegicus)
Mammalia Vom1r52 34
  • 62.58 (n)
chimpanzee
(Pan troglodytes)
Mammalia VN1R3 35
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia monDomV1R1235 35
  • 45 (a)
OneToMany
monDomV1R1234 35
  • 42 (a)
OneToMany
monDomV1R1224 35
  • 41 (a)
OneToMany
monDomV1R1225 35
  • 40 (a)
OneToMany
monDomV1R1271 35
  • 39 (a)
OneToMany
monDomV1R1272 35
  • 39 (a)
OneToMany
monDomV1R1281 35
  • 39 (a)
OneToMany
monDomV1R1282 35
  • 39 (a)
OneToMany
monDomV1R1283 35
  • 39 (a)
OneToMany
monDomV1R1228 35
  • 39 (a)
OneToMany
monDomV1R1223 35
  • 39 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
monDomV1R1238 35
  • 38 (a)
OneToMany
monDomV1R1233 35
  • 38 (a)
OneToMany
monDomV1R1243 35
  • 37 (a)
OneToMany
monDomV1R1270 35
  • 37 (a)
OneToMany
monDomV1R1294 35
  • 37 (a)
OneToMany
monDomV1R1239 35
  • 37 (a)
OneToMany
monDomV1R1236 35
  • 37 (a)
OneToMany
monDomV1R1232 35
  • 37 (a)
OneToMany
monDomV1R1230 35
  • 37 (a)
OneToMany
monDomV1R1246 35
  • 36 (a)
OneToMany
monDomV1R1267 35
  • 36 (a)
OneToMany
monDomV1R1290 35
  • 36 (a)
OneToMany
monDomV1R1292 35
  • 36 (a)
OneToMany
monDomV1R1231 35
  • 36 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
monDomV1R1244 35
  • 35 (a)
OneToMany
monDomV1R1245 35
  • 35 (a)
OneToMany
monDomV1R1259 35
  • 35 (a)
OneToMany
monDomV1R1261 35
  • 35 (a)
OneToMany
monDomV1R1266 35
  • 35 (a)
OneToMany
monDomV1R1280 35
  • 35 (a)
OneToMany
monDomV1R1221 35
  • 35 (a)
OneToMany
monDomV1R1242 35
  • 34 (a)
OneToMany
monDomV1R1254 35
  • 34 (a)
OneToMany
monDomV1R1257 35
  • 34 (a)
OneToMany
monDomV1R1258 35
  • 34 (a)
OneToMany
monDomV1R1260 35
  • 34 (a)
OneToMany
monDomV1R1268 35
  • 34 (a)
OneToMany
monDomV1R1256 35
  • 33 (a)
OneToMany
monDomV1R1263 35
  • 32 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Vmn1r83 35
  • 36 (a)
OneToMany
Species where no ortholog for VN1R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VN1R1 Gene

ENSEMBL:
Gene Tree for VN1R1 (if available)
TreeFam:
Gene Tree for VN1R1 (if available)

Paralogs for VN1R1 Gene

Variants for VN1R1 Gene

Sequence variations from dbSNP and Humsavar for VN1R1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10669418 -- 57,458,509(+) AAAAA(-/AA)CTCAG upstream-variant-2KB
rs112252871 -- 57,456,090(+) AACTC(C/T)TGTGC reference, missense
rs113071728 -- 57,456,371(+) TTTCA(C/T)CAAAA reference, missense
rs113566054 -- 57,457,858(+) AGCCT(-/C)CTGGG upstream-variant-2KB
rs114002003 -- 57,456,295(+) AGAAA(A/G)GAATT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for VN1R1 Gene

Variant ID Type Subtype PubMed ID
esv3583608 CNV loss 25503493

Variation tolerance for VN1R1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VN1R1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VN1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VN1R1 Gene

Disorders for VN1R1 Gene

Relevant External Links for VN1R1

Genetic Association Database (GAD)
VN1R1
Human Genome Epidemiology (HuGE) Navigator
VN1R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VN1R1

No disorders were found for VN1R1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VN1R1 Gene

Publications for VN1R1 Gene

  1. A putative pheromone receptor gene expressed in human olfactory mucosa. (PMID: 10973240) Rodriguez I. … Mombaerts P. (Nat. Genet. 2000) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PMID: 12826614) Zhang J. … Webb D.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64

Products for VN1R1 Gene

Sources for VN1R1 Gene

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