VN1R1 Gene
protein-coding GIFtS: 48
GCID: GC19M057966
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vomeronasal 1 receptor 1(Previous names: vomeronasal olfactory receptor, (chromosome 19) subtype...)
(Previous symbol: VNR19I1)
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Aliases
for VN1R1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vomeronasal 1 Receptor 11 2 | | G-Protein Coupled Receptor GPCR242 3 | | V1RL11 2 3 5 | | HGPCR241 | | VNR19I11 2 3 | | V1r-Like Receptor 12 3 | | ZVNH11 2 | | V3r-Related Gene Protein2 3 | | ZVNR11 2 | | V1R-Like 12 | | Vomeronasal Olfactory Receptor, (Chromosome 19) Subtype I, Member 11 2 | | Vomeronasal Type-1 Receptor 12 | | Vomeronasal Olfactory Receptor Chromosome 19 Subtype I Member 12 3 | | |
Export aliases for VN1R1 gene to outside databasesPrevious GC identifers: GC19M058408 GC19M062642 GC19M062658 GC19M054279 |
Summaries
for VN1R1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VN1R1:
Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients ofthe same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to theolfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has notbeen determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: VN1R1_HUMAN, Q9GZP7Function: Putative pheromone receptor
Gene Wiki entry for VN1R1
|
Genomic Views
for VN1R1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VN1R1 gene promoter:
COUP-TF1 FAC1 COUP-TF HTF COUP HNF-4alpha2 XBP-1 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for VN1R1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VN1R1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.4VN1R1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M057966: view genomic region
(about GC identifiers)
Start:
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57,966,542 bp from pter |
End:
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57,967,854 bp from pter |
Size:
|
1,313 bases |
Orientation:
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minus strand |
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Proteins
for VN1R1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VN1R1_HUMAN, Q9GZP7 (See
protein sequence)Recommended Name: Vomeronasal type-1 receptor 1 Size: 353 amino acids; 40021 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes
Secondary accessions: B3KSV5 Q7Z5H8 Q7Z5H9Explore the universe of human proteins at neXtProt for VN1R1: NX_Q9GZP7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9GZP7
VN1R1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065684.1
ENSEMBL proteins: ENSP00000322339
Human Recombinant Protein Products for VN1R1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
VN1R1 for ontologies About GeneDecksing
VN1R1 Antibody Products:
Assay Products for VN1R1: |
Protein
Domains /
Families
for VN1R1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VN1R1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9GZP7ProtoNet protein and cluster: Q9GZP7 UniProtKB/Swiss-Prot: VN1R1_HUMAN, Q9GZP7Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for VN1R1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: VN1R1_HUMAN, Q9GZP7Function: Putative pheromone receptor Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016503 | pheromone receptor activity |
IEA | -- |
VN1R1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for VN1R1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VN1R1 (NM_020633) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VN1R1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VN1R1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VN1R1 |
|
Pathways & Interactions
for VN1R1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | GPCRs, Other | |
1  BioSystems Pathway for VN1R1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VN1R1
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0019236 | response to pheromone |
IEA | -- |
VN1R1 for ontologies About GeneDecksing
|
Drugs & Compounds
for VN1R1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VN1R1
Search CenterWatch for drugs/clinical trials and news about VN1R1
|
Transcripts
for VN1R1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VN1R1 gene: NM_020633.3 Unigene Cluster for VN1R1: Vomeronasal 1 receptor 1 Hs.677423 [show with all ESTs]Unigene Representative Sequence: AK0944521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000321039(uc002qos.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VN1R1 (NM_020633) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VN1R1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VN1R1 |
Additional cDNA sequence: AF255342.1 AF302903.1 AK094452.1 BC095508.1 1 DOTS entry: DT.91742876 24/74 AceView cDNA sequences (see all 74): AI801007 CD630261 CD630263 CR594998 AF255342 BU931511 BX110882 AF302903 NM_020633 BM664629 AA505364 CD630267 AA936324 AI985650 BP871816 BQ709844 BG717450 BG167434 AA334110 CD105575 CA393613 CD642604 BX442402 BM721740
GeneLoc Exon Structure
|
Expression
for VN1R1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VN1R1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATACTGTTA
About this image
See VN1R1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VN1R1
SOURCE GeneReport for Unigene cluster: Hs.677423
UniProtKB/Swiss-Prot: VN1R1_HUMAN, Q9GZP7Tissue specificity: Expressed in the olfactory mucosa, very low expression in brain, lung and kidney
SABiosciences Custom PCR Arrays for VN1R1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VN1R1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat VN1R1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VN1R1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VN1R1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VN1R1 |
Orthologs
for VN1R1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for VN1R1 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Vmn1r705 |
vomeronasal 1 receptor 70 |
-- |
|
7 (6.55 cM) 10633587 |
ENSEMBL Gene Tree for VN1R1 (if available)
TreeFam Gene Tree for VN1R1 (if available) |
Paralogs
for VN1R1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VN1R1 gene
- VN1R22 VN1R42
3 SIMAP similar genes for VN1R1 using alignment to 1 protein entry: VN1R1_HUMAN:VN1R3 VN1R2 VN1R4
VN1R1 for paralogs About GeneDecksing
5/16 Pseudogenes.org Pseudogenes for VN1R1 (see all 16)
PGOHUM00000238575 PGOHUM00000234317 PGOHUM00000234427 PGOHUM00000234784 PGOHUM00000259433
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Genomic Variants
for VN1R1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VN1R1 (57966542 - 57967854 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VN1R1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VN1R1 |
|
Disorders
/ Diseases
for VN1R1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 VN1R1 for disorders About MalaCards
VN1R1 for disorders About GeneDecksing
OMIM gene information: 605234
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: VN1R1 (2 documents)
Export disorders for VN1R1 gene to outside databases
|
Publications
for VN1R1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VN1R1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with VN1R1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A putative pheromone receptor gene expressed in human olfactory mucosa. (PubMed id 10973240)1, 2, 3 Rodriguez I.... Mombaerts P. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. (PubMed id 12826614)1, 2 Zhang J. and Webb D.M. (2003)
- Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Extreme variability among mammalian V1R gene families . (PubMed id 19952141)1 Young J.M....Trask B.J. (2010)
- Association study of human VN1R1 pheromone receptor gene alleles and gender. (PubMed id 17627382)1 Mitropoulos C....Patrinos G.P. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A novel family of candidate pheromone receptors in mammals. (PubMed id 11163270)1 Pantages E. and Dulac C. (2000)
|
External Searches for VN1R1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VN1R1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VN1R1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VN1R1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VN1R1 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt061.shtml |
|
| | |
About This Section
| Patent Information for VN1R1 gene:
Search GeneIP for patents involving VN1R1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VN1R1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VN1R1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VN1R1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VN1R1 | | | OriGene Protein Over-expression Lysate for VN1R1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VN1R1 | | OriGene 3'-UTR Clone for VN1R1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VN1R1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VN1R1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VN1R1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VN1R1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VN1R1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VN1R1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VN1R1 |
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 | | | VN1R1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VN1R1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VN1R1 |
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