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VMP1 Gene

protein-coding   GIFtS: 45
GCID: GC17P057785

Vacuole Membrane Protein 1

(Previous name: transmembrane protein 49)
(Previous symbol: TMEM49)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vacuole Membrane Protein 11 2     Transport And Golgi Organization 5 Homolog (Drosophila)1
TMEM491 2 3 5     TANGO52
Transmembrane Protein 491 2 3     Ectopic P-Granules Autophagy Protein 3 Homolog2
EPG32 5     Transport And Golgi Organization 5 Homolog2
Ectopic P-Granules Autophagy Protein 3 Homolog (C. Elegans)1     TDC13

External Ids:    HGNC: 295591   Entrez Gene: 816712   Ensembl: ENSG000000627167   OMIM: 6117535   UniProtKB: Q96GC93   

Export aliases for VMP1 gene to outside databases

Previous GC identifers: GC17P057536 GC17P060234 GC17P058126 GC17P058259 GC17P055139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for VMP1 Gene:
VMP1 (vacuole membrane protein 1) is a protein-coding gene. Diseases associated with VMP1 include acute pancreatitis, and fanconi's anemia.

UniProtKB/Swiss-Prot: VMP1_HUMAN, Q96GC9
Function: Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed
by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute
pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By
similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions

Gene Wiki entry for VMP1 (TMEM49) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for VMP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVMP1 promoter sequence
   Search Chromatin IP Primers for VMP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1   Ensembl cytogenetic band:  17q23.1   HGNC cytogenetic band: 17q23.2

VMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VMP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P057785:  view genomic region     (about GC identifiers)

Start:
57,784,553 bp from pter      End:
57,919,616 bp from pter
Size:
135,064 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VMP1_HUMAN, Q96GC9 (See protein sequence)
Recommended Name: Vacuole membrane protein 1  
Size: 406 amino acids; 46238 Da
Subunit: Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2
Secondary accessions: Q9H0P4 Q9P089

Explore the universe of human proteins at neXtProt for VMP1: NX_Q96GC9

Explore proteomics data for VMP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VMP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112200.2  
    ENSEMBL proteins: 
     ENSP00000262291   ENSP00000465972   ENSP00000466579   ENSP00000465947   ENSP00000466413  
     ENSP00000466198   ENSP00000467093   ENSP00000466511   ENSP00000465397   ENSP00000465911  
     ENSP00000467350   ENSP00000446230   ENSP00000445130   ENSP00000444969   ENSP00000439959  

    VMP1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    LSBio Antibodies in human, mouse, rat for VMP1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96GC9

    UniProtKB/Swiss-Prot: VMP1_HUMAN, Q96GC9
    Similarity: Belongs to the VMP1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VMP1_HUMAN, Q96GC9
    Function: Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed
    by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute
    pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By
    similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17724469
         
    VMP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for VMP1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VMP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VMP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VMP1

    miRNA
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    miRTarBase miRNAs that target VMP1:
    hsa-mir-25-3p (MIRT050331), hsa-mir-296-3p (MIRT038376), hsa-mir-16-5p (MIRT031480), hsa-mir-1 (MIRT023611), hsa-mir-210-3p (MIRT006663)

    Block miRNA regulation of human, mouse, rat VMP1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate VMP1:
    hsa-miR-142-5p hsa-miR-3673 hsa-miR-561 hsa-miR-106a* hsa-miR-340 hsa-miR-373* hsa-miR-616* hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidVMP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VMP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VMP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VMP1_HUMAN, Q96GC9: Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein
    (By similarity). Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein (By
    similarity). Endoplasmic reticulum

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure IEA--
    GO:0000421autophagic vacuole membrane ISS--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    VMP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VMP1
    Interactions:

        Search GeneGlobe Interaction Network for VMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for VMP1 (Q96GC93 ENSP000002622914) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071573, ENSP000002815374I2D: score=1 STRING: ENSP00000281537
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    BECN1Q144573I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0007566embryo implantation IEA--
    GO:0010506regulation of autophagy ISS--
    GO:0016337cell-cell adhesion IMP17724469
    GO:0034329cell junction assembly IMP17724469

    VMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VMP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VMP1 gene: 
    NM_030938.3  

    Unigene Cluster for VMP1:

    Vacuole membrane protein 1
    Hs.444569  [show with all ESTs]
    Unigene Representative Sequence: AY699265
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000588915 ENST00000262291(uc002ixu.4 uc010wog.2 uc010woh.2 uc010woi.2 uc010woj.2)
    ENST00000593168 ENST00000586245 ENST00000585847 ENST00000587945 ENST00000588131
    ENST00000589823 ENST00000592106 ENST00000591315 ENST00000587259 ENST00000592619
    ENST00000591877 ENST00000591782 ENST00000588617 ENST00000592790 ENST00000587470
    ENST00000545362
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate VMP1:
    hsa-miR-142-5p hsa-miR-3673 hsa-miR-561 hsa-miR-106a* hsa-miR-340 hsa-miR-373* hsa-miR-616* hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidVMP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat VMP1
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    GenScript: all cDNA clones in your preferred vector: VMP1 (NM_030938)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VMP1
    Primer
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    OriGene qPCR primer pairs and template standards for VMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for VMP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VMP1
      QuantiTect SYBR Green Assays in human, mouse, rat VMP1
      QuantiFast Probe-based Assays in human, mouse, rat VMP1

    Additional mRNA sequence: 

    AB047551.1 AF161410.1 AK024969.1 AK025987.1 AK293578.1 AK293664.1 AK294854.1 AK301254.1 
    AL136711.1 AY699265.1 BC009758.2 BC053563.1 CR533521.1 

    Selected DOTS entries (see all 48):

    DT.101970657  DT.120930755  DT.40108044  DT.120930349  DT.217547  DT.100890885  DT.100890846  DT.120930612 
    DT.100643276  DT.416288  DT.120930768  DT.99938105  DT.120930472  DT.40108214  DT.120930578  DT.97851773 
    DT.120930568  DT.92469321  DT.100024551  DT.120930585  DT.95374904  DT.120930532  DT.120930764  DT.97859832 

    Selected AceView cDNA sequences (see all 653):

    BM802162 BX339614 BM978449 AI248273 BM803147 BE857251 BM795745 AL515603 
    CA424445 BM782304 AI570028 CB216599 N62339 BU615295 AA235803 AI273257 
    AI247243 Z45792 BF724505 AI683389 CA422783 AI357348 BQ002662 AA515544 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VMP1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:              -                 -                                               -     -                                 
    SP2:                                                                                                                        
    SP3:                                -                                                                                       
    SP4:                                                                                                                        
    SP5:                                                                                            -                           


    ECgene alternative splicing isoforms for VMP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTCAAAGA
    VMP1 Expression
    About this image

    VMP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VMP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444569
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VMP1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vmp11 , 5 vacuole membrane protein 11, 5 91.05(n)1
    94.09(a)1
      11 (51.82 cM)5
    759091  NM_029478.31  NP_083754.21 
     865838655 
    chicken
    (Gallus gallus)
    Aves VMP11 vacuole membrane protein 1 80.54(n)
    85.47(a)
      417635  XM_004946714.1  XP_004946771.1 
    lizard
    (Anolis carolinensis)
    Reptilia VMP16
    vacuole membrane protein 1
    84(a)
    1 ↔ 1
    GL343470.1(230532-295051)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136972 Xenopus laevis transcribed sequence with weak similarity more 80(n)    BJ627024.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.9822 Danio rerio, Similar to vacuole Membrane Protein 1, more 76.97(n)    BC046904.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango51 Transport and Golgi organization 5 56.27(n)
    56.18(a)
      326232  NM_167244.3  NP_727446.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37D8A.223
    epg-31
    epg-31 51(a)3
    54.79(n)1
    49.17(a)1
      III(13005825-13007934)3
    1767121  NM_067287.51  NP_499688.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G053601 AT1G05360 50.64(n)
    39.88(a)
      837035  NM_100415.4  NP_563735.1 
    rice
    (Oryza sativa)
    Liliopsida Os.143512 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.69(n)    AK064933.1 


    ENSEMBL Gene Tree for VMP1 (if available)
    TreeFam Gene Tree for VMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VMP1 gene
    1 SIMAP similar gene for VMP1 using alignment to 15 protein entries:     VMP1_HUMAN (see all proteins):
    TMEM49

    VMP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for VMP1
    PGOHUM00000259608


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VMP1 (see all 2044)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs589013521,2
    C--57786944(+) AGATAC/TGTCAG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs766517011,2
    F--57786994(+) TATCAC/TATACT 1 -- int11Minor allele frequency- T:0.14WA 118
    rs733330371,2
    C--57787043(+) AAAGAA/GTAGTT 1 -- int12Minor allele frequency- G:0.04WA 120
    rs1485761511,2
    C--57787367(+) TCCTGC/GCTAAT 1 -- int10--------
    rs1117230171,2
    C--57787431(+) CAGGCC/GCCTGT 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1477188071,2
    --57787455(+) CCGGAC/GGCTGA 1 -- int10--------
    rs1815172441,2
    --57787489(+) GGAGGC/TGGAGC 1 -- int10--------
    rs1864084421,2
    --57787490(+) GAGGCA/GGAGCT 1 -- int10--------
    rs1915628321,2
    --57787529(+) CTCCAG/TCCTGG 1 -- int10--------
    rs1828997981,2
    --57787603(+) TTAGAA/GTTAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for VMP1 (57784553 - 57919616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for VMP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662935CNV Deletion23128226
    esv2716083CNV Deletion23290073
    esv2483856CNV Deletion19546169
    nsv821151CNV Deletion20802225
    dgv3238n71CNV Loss21882294
    nsv833501CNV Loss17160897
    nsv512497CNV Loss21212237
    nsv908651CNV Loss21882294
    esv998658CNV Gain20482838
    nsv828072CNV Gain+Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611753    OMIM disorders: --

    9 diseases for VMP1:    About MalaCards
    acute pancreatitis    fanconi's anemia    pancreatitis    hypoxia
    pancreatic cancer    lung cancer    hepatocellular carcinoma    breast cancer
    malaria


    VMP1 for disorders           About GeneDecksing


    Export disorders for VMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VMP1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with VMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. The TP53INP2 protein is required for autophagy in mammalian cells. (PubMed id 19056683)1, 2 Nowak J.... Iovanna J.L. (Mol. Biol. Cell 2009)
    3. Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells. (PubMed id 17724469)1, 2 Sauermann M.... Arlt D. (Oncogene 2008)
    4. Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation. (PubMed id 11785947)1, 3 Dusetti N.J....Iovanna J.L. (Biochem. Biophys. Res. Commun. 2002)
    5. [Expression of vacuole membrane protein 1 and its prognostic value in invasive ductal carcinoma of the breast]. (PubMed id 23710913)1 Liu F....Zhang T.X. (Zhonghua Bing Li Xue Za Zhi 2013)
    6. The VMP1-Beclin 1 interaction regulates autophagy induction. (PubMed id 23316280)1 Molejon M.I....Vaccaro M.I. (Sci Rep 2013)
    7. VMP1 related autophagy and apoptosis in colorectal cancer cells: VMP1 regulates cell death. (PubMed id 24365149)1 Qian Q....Gu W. (Biochem. Biophys. Res. Commun. 2013)
    8. Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs. (PubMed id 23460482)1 Gilabert M....Iovanna J.L. (J. Cell. Physiol. 2013)
    9. Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. (PubMed id 23118302)1 Chu A.Y....Ridker P.M. (Circ Cardiovasc Genet 2012)
    10. Novel roles of Vmp1: inhibition metastasis and proliferation of hepatocellular carcinoma. (PubMed id 22971212)1 Guo L....Wu F. (Cancer Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81671 HGNC: 29559 AceView: VMP1 Ensembl:ENSG00000062716 euGenes: HUgn81671
    ECgene: VMP1 H-InvDB: VMP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VMP1 gene:
    Search GeneIP for patents involving VMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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