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VMO1 Gene(Protein Coding)

Vitelline Membrane Outer Layer 1 Homolog

GCID:
GC17M004786
GIFtS:
43
Genes Participants
UDN Logo

Aliases for VMO1 Gene

Aliases for VMO1 Gene

  • Vitelline Membrane Outer Layer 1 Homolog 2 3
  • Vitelline Membrane Outer Layer 1 Homolog (Chicken) 2 5
  • ERGA6350 3
  • PRO21055 3

External Ids for VMO1 Gene

Previous GeneCards Identifiers for VMO1 Gene

  • GC17M004636
  • GC17M004688
  • GC17M004576

Summaries for VMO1 Gene

GeneCards Summary for VMO1 Gene

VMO1 (Vitelline Membrane Outer Layer 1 Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VMO1 Gene

Genomics for VMO1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for VMO1 Gene

Enhancers for VMO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VMO1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the VMO1 gene promoter:

Genomic Location for VMO1 Gene

Chromosome:
17
Start:
4,785,285 bp from pter
End:
4,786,434 bp from pter
Size:
1,150 bases
Orientation:
Minus strand

Genomic View for VMO1 Gene

Genes around VMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VMO1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for VMO1 Gene

Proteins for VMO1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for VMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5L0-VMO1_HUMAN
    Recommended name:
    Vitelline membrane outer layer protein 1 homolog
    Protein Accession:
    Q7Z5L0
    Secondary Accessions:
    • C9JQ15
    • E9PAU9
    • E9PGP4
    • Q3SXP1
    • Q8IUY1

    Protein attributes for VMO1 Gene

    Size:
    202 amino acids
    Molecular mass:
    21534 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VMO1 Gene

Proteomics data for VMO1 Gene at MOPED

Protein Expression for VMO1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for VMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VMO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VMO1 Gene

Domains & Families for VMO1 Gene

Protein Domains for VMO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5L0

UniProtKB/Swiss-Prot:

VMO1_HUMAN :
  • Belongs to the VMO1 family.
Family:
  • Belongs to the VMO1 family.
genes like me logo Genes that share domains with VMO1: view

No data available for Gene Families for VMO1 Gene

Function for VMO1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for VMO1 Gene

GenomeRNAi human phenotypes for VMO1:
genes like me logo Genes that share phenotypes with VMO1: view

Animal Model Products

miRNA for VMO1 Gene

miRTarBase miRNAs that target VMO1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VMO1 Gene

Localization for VMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VMO1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VMO1 Gene COMPARTMENTS Subcellular localization image for VMO1 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for VMO1 Gene

Pathways & Interactions for VMO1 Gene

SuperPathways for VMO1 Gene

PathCards logoMore details on SuperPathways for VMO1
No Data Available

Interacting Proteins for VMO1 Gene

Gene Ontology (GO) - Biological Process for VMO1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VMO1 Gene

Drugs & Compounds for VMO1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for VMO1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for VMO1 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VMO1 Gene

Vitelline membrane outer layer 1 homolog (chicken):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VMO1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:
SP3: - -

Relevant External Links for VMO1 Gene

GeneLoc Exon Structure for
VMO1
ECgene alternative splicing isoforms for
VMO1

Expression for VMO1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for VMO1 Gene

mRNA expression in normal human tissues for VMO1 Gene
mRNA expression by BioGPS for VMO1 GenemRNA expression by GTEx for VMO1 Gene

mRNA differential expression in normal tissues according to GTEx for VMO1 Gene

This gene is overexpressed in Spleen (x7.3) and Pituitary (x7.1).

Protein differential expression in normal tissues from HIPED for VMO1 Gene

This gene is overexpressed in Urine (60.1) and Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VMO1 Gene



SOURCE GeneReport for Unigene cluster for VMO1 Gene Hs.122561

genes like me logo Genes that share expression patterns with VMO1: view

Protein tissue co-expression partners for VMO1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for VMO1 Gene

Orthologs for VMO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VMO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia VMO1 35
  • 82.08 (n)
  • 78.89 (a)
VMO1 36
  • 78 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia VMO1 35
  • 78.11 (n)
  • 76.62 (a)
VMO1 36
  • 77 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Vmo1 35
  • 73.3 (n)
  • 71.64 (a)
Vmo1 16
Vmo1 36
  • 72 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia VMO1 35
  • 99.17 (n)
  • 98.02 (a)
VMO1 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Vmo1 35
  • 78.56 (n)
  • 78.95 (a)
oppossum
(Monodelphis domestica)
 Mammalia VMO1 36
  • 69 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia VMO1 36
  • 44 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves VMO1 35
  • 58.28 (n)
  • 59.12 (a)
VMO1 36
  • 53 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia VMO1 36
  • 39 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC101731130 35
  • 57.37 (n)
  • 56.97 (a)
zebrafish
(Danio rerio)
 Actinopterygii LOC793369 35
  • 54.27 (n)
  • 53.66 (a)
VMO1 (1 of 2) 36
  • 47 (a)
 OneToMany
VMO1 (2 of 2) 36
  • 43 (a)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.804 35
worm
(Caenorhabditis elegans)
 Secernentea C08G5.3 36
  • 12 (a)
 OneToMany
C47A10.12 36
  • 21 (a)
 OneToMany
F28A10.8 36
  • 29 (a)
 OneToMany
F46F5.13 36
  • 30 (a)
 OneToMany
K07E8.1 36
  • 28 (a)
 OneToMany
T02H6.9 36
  • 29 (a)
 OneToMany
Y38H6C.19 36
  • 36 (a)
 OneToMany
Y39F10C.1 36
  • 18 (a)
 OneToMany
Y40B10B.1 36
  • 19 (a)
 OneToMany
Y54E2A.9 36
  • 29 (a)
 OneToMany
Y57G11A.2 36
  • 8 (a)
 OneToMany
Y9C9A.1 36
  • 19 (a)
 OneToMany
Species with no ortholog for VMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VMO1 Gene

ENSEMBL:
Gene Tree for VMO1 (if available)
TreeFam:
Gene Tree for VMO1 (if available)

Paralogs for VMO1 Gene

No data available for Paralogs for VMO1 Gene

Variants for VMO1 Gene

Sequence variations from dbSNP and Humsavar for VMO1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2279961 - 4,786,018(-) CGACA(C/G)TGCAC intron-variant, reference, missense
rs4790706 - 4,786,277(+) ATCTG(C/T)CTGTG reference, missense
rs2279962 -- 4,785,701(-) GTGAA(G/T)GGGGG intron-variant
rs3215170 -- 4,785,900(-) TGATG(-/G)TATGT intron-variant, splice-donor-variant
rs55992208 -- 4,785,246(+) TAAAT(-/TAATAAATAAAT)AAATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for VMO1 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv907618 CNV Loss 21882294
nsv833347 CNV Loss 17160897

Variation tolerance for VMO1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VMO1 Gene

Disorders for VMO1 Gene

Relevant External Links for VMO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VMO1

No disorders were found for VMO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VMO1 Gene

Publications for VMO1 Gene

  1. Analysis and comparison of proteomic profiles of tear fluid from human, cow, sheep, and camel eyes. (PMID: 22025569) Shamsi F.A. … Wu K. (Invest. Ophthalmol. Vis. Sci. 2011) 2 3 67
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3

Products for VMO1 Gene

Sources for VMO1 Gene

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