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VMO1 Gene

protein-coding GIFtS: 41

GC17M004636

vitelline membrane outer layer 1 homolog (chicken)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ERGA6350 ^²
MGC125880 ^²
MGC125881 ^²
PRO21055 ^²

Descriptions
vitelline membrane outer layer 1 ^²
vitelline membrane outer layer 1 homolog (chicken) ^²

External Ids
HGNC: 30387¹
Entrez Gene: 284013²
UniProtKB: Q7Z5L0³
Ensembl: ENSG00000182853⁷

Search outside databases for aliases for VMO1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VMO1 gene

Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2

VMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M004636: (about GC identifiers)

Start:	4,635,320 bp from pter
End:	4,636,473 bp from pter
Size:	1,154 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VMO1_HUMAN, Q7Z5L0 (See protein sequence)

Recommended Name: Vitelline membrane outer layer protein 1 homolog precursor

Size: 202 amino acids; 21534 Da

Subcellular location: Secreted (Probable)

Secondary accessions: Q3SXP1

REFSEQ proteins (4 alternative transcripts):

NP_001138411.1 NP_001138412.1 NP_001138413.1 NP_872372.1

ENSEMBL proteins:

ENSP00000346133 ENSP00000328397

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: VMO1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for VMO1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for VMO1

Assays for VMO1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q7Z5L0

ProtoNet protein and cluster: Q7Z5L0

UniProtKB/Swiss-Prot: VMO1_HUMAN, Q7Z5L0

Similarity: Belongs to the VMO1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VMO1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001144939

Applied Biosystems Silencer® siRNAs for VMO1

Sigma-Aldrich siRNA for VMO1

Sigma-Aldrich shRNA for VMO1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VMO1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001144939
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001144939
untagged cDNA clones in CMV expression vector (see all 4): NM_001144939

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_182566

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008316	structural constituent of vitelline membrane	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030704	vitelline membrane formation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VMO1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VMO1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001144939

Sigma-Aldrich siRNA for VMO1

Sigma-Aldrich shRNA for VMO1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_182566

REFSEQ mRNAs for VMO1 gene (4 alternative transcripts):

NM_001144939.1 NM_001144940.1 NM_001144941.1 NM_182566.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_182566

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001144939
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001144939
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001144939

Additional cDNA sequence:

AF521892.1 AY359099.1 BC038467.1 BC104194.2 BC104195.1

6 DOTS entries:

DT.436034 DT.80102098 DT.92418266 DT.95365922 DT.100022754 DT.100755071

24/34 AceView cDNA sequences (see all 34 ):

CA418809 AI096808 T35723 BQ575991 CD367284 CD367473 BU726217 BM693934

AA371985 AY359099 CB528310 BI836994 AI478392 BE218112 AI373466 NM_182566

AW963390 BU684331 AF521892 BM704806 BC038467 BE218357 CD369385 BF511222

highest scoring ESTs for VMO1:

AF521892 AY359099 BF511222 BG149530 BM693934 BM704806 BU684331 CB528310 AA371985 AA977975

Unigene Cluster for VMO1:

Vitelline membrane outer layer 1 homolog (chicken)

Hs.122561 [show with all ESTs]

Unigene Representative Sequence: BI838614

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for VMO1

ExUns:	1	^	2a	·	2b	^	3a	·	3b
SP1:					-
SP2:
SP3:			-		-

About this scheme

ECgene alternative splicing isoforms for VMO1

2 Ensembl transcripts including schematic representations:

ENST00000354194 ENST00000328739

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VMO1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VMO1

¹ / ² / ³

5 probe-sets matching VMO1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
88741_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI373466	0.60	1.00	0.82	1
235751_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA977975	0.60	1.00	0.82	1
241894_at²^{, 3}	U133-B	1	0.55	1.00	--	--	BG149530	0.80	1.00	0.91	1
235751_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241894_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

GeneDecks VMO1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TGCACAGGCA

SOURCE GeneReport for Unigene cluster: Hs.122561

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for VMO1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VMO1¹	--	vitelline membrane outer layer 1 homolog (chicken)	78.44(n) 77.11(a)	489457 XM_546575.1 XP_546575.1
chimpanzee (Pan troglodytes)	VMO1¹	--	vitelline membrane outer layer 1 homolog (chicken)	99.17(n) 98.02(a)	748359 XM_001161578.1 XP_001161578.1
rat (Rattus norvegicus)	Vmo1¹	--	vitelline membrane outer layer 1 homolog (chicken)	78.56(n) 78.95(a)	360553 XM_340832.3 XP_340833.2
mouse (Mus musculus)	Vmo1^{1, 5}	11⁵	vitelline membrane outer layer 1 homolog (chicken)^{1, 5}	73.47(n)¹ 72.14(a)¹	327956¹ NM_001013607.1¹ NP_001013625.1¹ AL592547⁵ BC152836⁵
chicken (Gallus gallus)	VMO1¹	--	vitelline membrane outer layer 1 homolog (chicken)	58.28(n) 59.12(a)	418974 XM_417168.2 XP_417168.2

About this table Species with no ortholog for VMO1

ENSEMBL Gene Tree for VMO1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/18 NCBI SNPs in VMO1 are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 26)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8078118^1,2	A,C,F,H	4636778(+)	`TCCAGC/AAGTGA`	1	--	ng3¹		12		EA NA EU WA	1056
	rs4790706^1,2	A,C,F,H	4636312(+)	`ATCTGT/CCTGTG`	1	A/T	mis¹		12		EA NA EU WA	1052
	rs2279961^1,2	A,C,F,H	4636053(-)	`CGACAC/GTGCAC`	1	T/S	mis¹ ese³		8		EA EU WA NA	2048
	rs2279962^1,2	A,C,F,H	4635736(-)	`GTGAAG/TGGGGG`	1	--	int¹ trp³		6		EA MN EU WA	2066
--	rs58428268^1,2	--	4634928(+)	`AATGCC/TAAGTT`	1	--	ng5¹		0	--	--	--	--
--	rs71367855^1,2	--	4635270(+)	`TCTCA-/AATAA ATAAATTAATAA`	1	--	ng5¹		0	--	--	--	--
--	rs67902769^1,2	--	4635109(+)	`ATACA-/AAAAAAA`	1	--	ng5¹		0	--	--	--	--
--	rs62073597^1,2	--	4635123(+)	`AAAATA/TAGCCG`	1	--	ng5¹		0	--	--	--	--
--	rs59498496^1,2	--	4635121(+)	`AAAAA-/AATTAGC`	1	--	ng5¹		0	--	--	--	--
--	rs72085299^1,2	--	4635281(+)	`TAAAT-/TAATA AATAAATAAATG`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for VMO1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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5 PubMed articles for VMO1 gene:

Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 284013	HGNC: 30387	AceView: LOC284013	Ensembl:ENSG00000182853	euGenes: HUgn284013
ECgene: VMO1	H-InvDB: VMO1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for VMO1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for VMO1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VMO1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VMO1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VMO1		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for VMO1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for VMO1

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VMO1 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for VMO1

Summaries
for VMO1

Genomic Location
for VMO1

Proteins
for VMO1

Protein Domains/
Families
for VMO1

Gene Function
for VMO1

Pathways & Interactions
for VMO1

Drugs & Compounds
for VMO1

Transcripts
for VMO1

Expression
for VMO1

Orthologs
for VMO1

Paralogs
for VMO1

SNPs/Variants
for VMO1

Disorders & Mutations
for VMO1

Medical News
for VMO1

Publications
for VMO1

Search for VMO1

Genome Databases showing VMO1

Other Databases showing VMO1

Specialized Databases showing VMO1

Licensable Technologies
for VMO1

Services
for VMO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VMO1 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor VMO1

Summariesfor VMO1

Genomic Locationfor VMO1

Proteinsfor VMO1

Protein Domains/Familiesfor VMO1

Gene Functionfor VMO1

Pathways & Interactionsfor VMO1

Drugs & Compoundsfor VMO1

Transcriptsfor VMO1

Expression for VMO1

Orthologsfor VMO1

Paralogsfor VMO1

SNPs/Variantsfor VMO1

Disorders & Mutationsfor VMO1

Medical Newsfor VMO1

Publicationsfor VMO1

Search for VMO1

Genome Databases showing VMO1

Other Databases showing VMO1

Specialized Databases showing VMO1

Licensable Technologiesfor VMO1

Servicesfor VMO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VMO1

Summaries
for VMO1

Genomic Location
for VMO1

Proteins
for VMO1

Protein Domains/
Families
for VMO1

Gene Function
for VMO1

Pathways & Interactions
for VMO1

Drugs & Compounds
for VMO1

Transcripts
for VMO1

Expression
for VMO1

Orthologs
for VMO1

Paralogs
for VMO1

SNPs/Variants
for VMO1

Disorders & Mutations
for VMO1

Medical News
for VMO1

Publications
for VMO1

Licensable Technologies
for VMO1

Services
for VMO1