VMO1 Gene
protein-coding GIFtS: 39
GCID: GC17M004688
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vitelline membrane outer layer 1 homolog (chicken)
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Aliases
for VMO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vitelline Membrane Outer Layer 1 Homolog (Chicken)1 2 | | ERGA63502 | | PRO210552 | | Vitelline Membrane Outer Layer Protein 1 Homolog2 |
Export aliases for VMO1 gene to outside databasesPrevious GC identifers: GC17M004636 GC17M004576 |
Summaries
for VMO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for VMO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VMO1 gene promoter:
STAT1 AP-1 ATF-2 Olf-1 FOXD1 STAT1beta Lmo2 STAT1alpha c-Jun LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for VMO1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VMO1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2VMO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M004688: view genomic region
(about GC identifiers)
Start:
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4,688,580 bp from pter |
End:
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4,689,729 bp from pter |
Size:
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1,150 bases |
Orientation:
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minus strand |
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Proteins
for VMO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VMO1_HUMAN, Q7Z5L0 (See
protein sequence)Recommended Name: Vitelline membrane outer layer protein 1 homolog precursor Size: 202 amino acids; 21534 Da
Subcellular location: Secreted (Probable)
Secondary accessions: E9PAU9 E9PGP4 Q3SXP1 Q8IUY1Alternative splicing: 3 isoforms: Q7Z5L0-1 Q7Z5L0-2 Q7Z5L0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for VMO1: NX_Q7Z5L0
VMO1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001138411.1 NP_001138412.1 NP_001138413.1 NP_872372.1
ENSEMBL proteins: ENSP00000408166 ENSP00000390450 ENSP00000328397 ENSP00000346133
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
VMO1 for ontologies About GeneDecksing
VMO1 Antibody Products:
Assay Products for VMO1: |
Protein
Domains /
Families
for VMO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VMO1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z5L0ProtoNet protein and cluster: Q7Z5L0 UniProtKB/Swiss-Prot: VMO1_HUMAN, Q7Z5L0Similarity: Belongs to the VMO1 family |
Function
for VMO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VMO1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VMO1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): VMO1 (NM_182566) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VMO1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VMO1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VMO1 |
2 GenomeRNAi human phenotypes for VMO1:
|
Pathways & Interactions
for VMO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VMO1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030704 | vitelline membrane formation |
IEA | -- |
VMO1 for ontologies About GeneDecksing
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Drugs & Compounds
for VMO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VMO1
Search CenterWatch for drugs/clinical trials and news about VMO1
|
Transcripts
for VMO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VMO1 gene (4 alternative transcripts): NM_001144939.1 NM_001144940.1 NM_001144941.1 NM_182566.2 Unigene Cluster for VMO1: Vitelline membrane outer layer 1 homolog (chicken) Hs.122561 [show with all ESTs]Unigene Representative Sequence: BI8386144 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441199 ENST00000416307 ENST00000328739(uc002fyx.3 uc010vsh.2 uc010vsi.2)
ENST00000354194(uc002fyy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VMO1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VMO1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): VMO1 (NM_182566) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VMO1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VMO1 |
Additional cDNA sequence: AF521892.1 AY359099.1 BC038467.1 BC104194.2 BC104195.1 6 DOTS entries: DT.436034 DT.80102098 DT.92418266 DT.95365922 DT.100022754 DT.100755071 24/34 AceView cDNA sequences (see all 34): CB528310 CD367473 T35723 BU726217 BQ575991 AY359099 BM693934 CD367284 AI096808 CA418809 AA371985 BM704806 AI478392 BC038467 BE218112 BI836994 BU684331 AI373466 NM_182566 AW963390 BE218357 AF521892 CD369385 BM685850
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for VMO1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
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| SP1: | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | - | | - | | | | | |
ECgene alternative splicing isoforms for VMO1
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Expression
for VMO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VMO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCACAGGCA
About this image
See VMO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VMO1
SOURCE GeneReport for Unigene cluster: Hs.122561
SABiosciences Custom PCR Arrays for VMO1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VMO1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat VMO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VMO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VMO1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VMO1 |
Orthologs
for VMO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for VMO1 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for VMO1 (if available)
TreeFam Gene Tree for VMO1 (if available) |
Paralogs
for VMO1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for VMO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VMO1 (4688580 - 4689729 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for VMO1
2 CNVs: 4986 4985 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VMO1 |
|
Disorders
/ Diseases
for VMO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for VMO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VMO1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with VMO1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for VMO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing VMO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VMO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VMO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VMO1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for VMO1 gene:
Search GeneIP for patents involving VMO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VMO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VMO1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VMO1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VMO1 | | | OriGene Protein Over-expression Lysate for VMO1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VMO1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VMO1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VMO1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VMO1 | | OriGene Custom Protein Services for VMO1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VMO1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VMO1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VMO1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VMO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VMO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VMO1 |
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| | | | Search Tocris compounds for VMO1 |
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 | | | VMO1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VMO1 |
|  |  |  | | | | Search ThermoFisher Antibodies for VMO1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VMO1 |
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