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Aliases for VMO1 Gene

Aliases for VMO1 Gene

  • Vitelline Membrane Outer Layer 1 Homolog 2 3 5
  • Vitelline Membrane Outer Layer 1 Homolog (Chicken) 2
  • Vitelline Membrane Outer Layer Protein 1 Homolog 3
  • ERGA6350 3
  • PRO21055 3

External Ids for VMO1 Gene

Previous GeneCards Identifiers for VMO1 Gene

  • GC17M004636
  • GC17M004688
  • GC17M004576

Summaries for VMO1 Gene

GeneCards Summary for VMO1 Gene

VMO1 (Vitelline Membrane Outer Layer 1 Homolog) is a Protein Coding gene.

Additional gene information for VMO1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VMO1 Gene

Genomics for VMO1 Gene

Regulatory Elements for VMO1 Gene

Enhancers for VMO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H004847 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -63.2 -63198 4 PKNOX1 MAX ZBTB40 RFX5 SMC3 RCOR1 FOS SMARCE1 STAT1 DPF2 CHRNE ENO3 PFN1 ZMYND15 ARRB2 C17orf107 PLD2 CXCL16 LOC101559451 PELP1
GH17H004786 1.1 ENCODE 14 -2.3 -2306 5 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 FOS ZNF594 LOC100130950 VMO1 LOC101927979 ANKFY1 PELP1 RNF167 GLTPD2 PSMB6
GH17H004842 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -58.1 -58067 3 CEBPB NFE2 SPI1 CHRNE ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 ENO3 PSMB6 RPS12P29 LOC101559451
GH17H004769 1.5 FANTOM5 Ensembl ENCODE 8.5 +15.1 15138 3 FOXA2 ARID4B DMAP1 YY1 SLC30A9 FOS PAF1 SP5 ZHX2 MXD4 CXCL16 ZMYND15 VMO1 ENSG00000262165 ARRB2 SPAG7 MINK1 SCIMP TM4SF5
GH17H004837 1.1 ENCODE dbSUPER 11.4 -52.7 -52675 3 HDAC1 TBP HDGF PKNOX1 TBL1XR1 ARNT ZSCAN4 ZBTB40 TCF12 GATA2 CHRNE ENO3 SPAG7 PLD2 GLTPD2 VMO1 CXCL16 ZMYND15 ENSG00000234203 PFN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VMO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VMO1 Gene

Chromosome:
17
Start:
4,785,285 bp from pter
End:
4,786,434 bp from pter
Size:
1,150 bases
Orientation:
Minus strand

Genomic View for VMO1 Gene

Genes around VMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VMO1 Gene

Proteins for VMO1 Gene

  • Protein details for VMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5L0-VMO1_HUMAN
    Recommended name:
    Vitelline membrane outer layer protein 1 homolog
    Protein Accession:
    Q7Z5L0
    Secondary Accessions:
    • C9JQ15
    • E9PAU9
    • E9PGP4
    • Q3SXP1
    • Q8IUY1

    Protein attributes for VMO1 Gene

    Size:
    202 amino acids
    Molecular mass:
    21534 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VMO1 Gene

Post-translational modifications for VMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VMO1 Gene

No data available for DME Specific Peptides for VMO1 Gene

Domains & Families for VMO1 Gene

Gene Families for VMO1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for VMO1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VMO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z5L0

UniProtKB/Swiss-Prot:

VMO1_HUMAN :
  • Belongs to the VMO1 family.
Family:
  • Belongs to the VMO1 family.
genes like me logo Genes that share domains with VMO1: view

Function for VMO1 Gene

Phenotypes From GWAS Catalog for VMO1 Gene

Gene Ontology (GO) - Molecular Function for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with VMO1: view
genes like me logo Genes that share phenotypes with VMO1: view

Animal Model Products

CRISPR Products

miRNA for VMO1 Gene

miRTarBase miRNAs that target VMO1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VMO1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VMO1 Gene

Localization for VMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VMO1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VMO1 gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with VMO1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VMO1 Gene

Pathways & Interactions for VMO1 Gene

No Data Available

Interacting Proteins for VMO1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328397%0d%0a9606.ENSP00000280098%0d%0a9606.ENSP00000240327%0d%0a
Selected Interacting proteins: Q7Z5L0-VMO1_HUMAN ENSP00000328397 for VMO1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for VMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with VMO1: view

No data available for Pathways by source and SIGNOR curated interactions for VMO1 Gene

Drugs & Compounds for VMO1 Gene

No Compound Related Data Available

Transcripts for VMO1 Gene

Unigene Clusters for VMO1 Gene

Vitelline membrane outer layer 1 homolog (chicken):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VMO1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VMO1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:
SP3: - -

Relevant External Links for VMO1 Gene

GeneLoc Exon Structure for
VMO1
ECgene alternative splicing isoforms for
VMO1

Expression for VMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VMO1 Gene

mRNA differential expression in normal tissues according to GTEx for VMO1 Gene

This gene is overexpressed in Spleen (x7.3) and Pituitary (x7.1).

Protein differential expression in normal tissues from HIPED for VMO1 Gene

This gene is overexpressed in Urine (60.1) and Nasal epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VMO1 Gene



Protein tissue co-expression partners for VMO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of VMO1 Gene:

VMO1

SOURCE GeneReport for Unigene cluster for VMO1 Gene:

Hs.122561

Evidence on tissue expression from TISSUES for VMO1 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with VMO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VMO1 Gene

Orthologs for VMO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VMO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VMO1 33 34
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia VMO1 33 34
  • 82.08 (n)
rat
(Rattus norvegicus)
Mammalia Vmo1 33
  • 78.56 (n)
dog
(Canis familiaris)
Mammalia VMO1 33 34
  • 78.11 (n)
mouse
(Mus musculus)
Mammalia Vmo1 33 16 34
  • 73.3 (n)
oppossum
(Monodelphis domestica)
Mammalia VMO1 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VMO1 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves VMO1 33 34
  • 58.28 (n)
lizard
(Anolis carolinensis)
Reptilia VMO1 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731130 33
  • 57.37 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC793369 33
  • 54.27 (n)
VMO1 (1 of 2) 34
  • 47 (a)
OneToMany
VMO1 (2 of 2) 34
  • 43 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.804 33
worm
(Caenorhabditis elegans)
Secernentea Y38H6C.19 34
  • 36 (a)
OneToMany
F46F5.13 34
  • 30 (a)
OneToMany
F28A10.8 34
  • 29 (a)
OneToMany
T02H6.9 34
  • 29 (a)
OneToMany
Y54E2A.9 34
  • 29 (a)
OneToMany
K07E8.1 34
  • 28 (a)
OneToMany
C47A10.12 34
  • 21 (a)
OneToMany
Y40B10B.1 34
  • 19 (a)
OneToMany
Y9C9A.1 34
  • 19 (a)
OneToMany
Y39F10C.1 34
  • 18 (a)
OneToMany
C08G5.3 34
  • 12 (a)
OneToMany
Y57G11A.2 34
  • 8 (a)
OneToMany
Species where no ortholog for VMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VMO1 Gene

ENSEMBL:
Gene Tree for VMO1 (if available)
TreeFam:
Gene Tree for VMO1 (if available)

Paralogs for VMO1 Gene

No data available for Paralogs for VMO1 Gene

Variants for VMO1 Gene

Sequence variations from dbSNP and Humsavar for VMO1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000138304 -- 4,788,385(+) CTACT(A/G)AAAAT upstream-variant-2KB
rs1000237291 -- 4,786,975(+) TAACA(C/G)CTTGA upstream-variant-2KB
rs1000458431 -- 4,786,668(+) TTGTA(G/T)ATGAG upstream-variant-2KB
rs1000466331 -- 4,788,081(+) ACGTG(C/T)GGAAG upstream-variant-2KB
rs1002404578 -- 4,786,645(+) GGGTG(A/T)GAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VMO1 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897
nsv833347 CNV loss 17160897

Variation tolerance for VMO1 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VMO1 Gene

Disorders for VMO1 Gene

Relevant External Links for VMO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VMO1

No disorders were found for VMO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VMO1 Gene

Publications for VMO1 Gene

  1. Analysis and comparison of proteomic profiles of tear fluid from human, cow, sheep, and camel eyes. (PMID: 22025569) Shamsi FA … Wu K (Investigative ophthalmology & visual science 2011) 2 3 60
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 60

Products for VMO1 Gene

Sources for VMO1 Gene

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