VMAC Gene
protein-coding GIFtS: 37
GCID: GC19P005904
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vimentin-type intermediate filament associated coiled-coil...
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Aliases
for VMAC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vimentin-Type Intermediate Filament Associated Coiled-Coil Protein1 2 | | Vimentin-Type IF-Associated Coiled-Coil Protein2 | | Vimentin-Type Intermediate Filament-Associated Coiled-Coil Protein2 |
Export aliases for VMAC gene to outside databasesPrevious GC identifers: GC19P005855 GC19P005664 |
Summaries
for VMAC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for VMAC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VMAC gene promoter:
AP-1 ATF-2 MIF-1 c-Jun Pax-4a E47 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for VMAC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VMAC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3VMAC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P005904: view genomic region
(about GC identifiers)
Start:
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5,904,852 bp from pter |
End:
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5,910,864 bp from pter |
Size:
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6,013 bases |
Orientation:
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plus strand |
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Proteins
for VMAC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VMAC_HUMAN, Q2NL98 (See
protein sequence)Recommended Name: Vimentin-type intermediate filament-associated coiled-coil protein Size: 169 amino acids; 18348 Da
Subcellular location: Cytoplasm (By similarity). Note=Colocalizes with vimentin-type intermediate filaments (Bysimilarity)
Secondary accessions: B3KW55Explore the universe of human proteins at neXtProt for VMAC: NX_Q2NL98
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2NL98
VMAC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001017921.1
ENSEMBL proteins: ENSP00000343348
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
VMAC for ontologies About GeneDecksing
VMAC Antibody Products:
Assay Products for VMAC: |
Protein
Domains /
Families
for VMAC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q2NL98 |
Function
for VMAC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VMAC (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VMAC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: VMAC (NM_001017921) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VMAC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VMAC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VMAC |
|
Pathways & Interactions
for VMAC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VMAC
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for VMAC (Q2NL983 ENSP000003433484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for VMAC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VMAC
Search CenterWatch for drugs/clinical trials and news about VMAC
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Transcripts
for VMAC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VMAC gene: NM_001017921.3 Unigene Cluster for VMAC: Vimentin-type intermediate filament associated coiled-coil protein Hs.620821 [show with all ESTs]Unigene Representative Sequence: AK1241621 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000339485(uc002mds.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VMAC (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VMAC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VMAC (NM_001017921) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VMAC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VMAC |
Additional cDNA sequence: AK124162.1 BC110802.1 1 DOTS entry: DT.101970284 24/186 AceView cDNA sequences (see all 186): BQ673321 BG767590 CF128141 AI624988 CR601253 CA396674 BG950416 CK821926 BE396135 AI613142 CR623055 BM712749 BM699638 AI628545 AW513409 BM725337 AW151211 AI924700 BQ436748 BQ673294 AI560810 BM716373 BU689238 AW510425
GeneLoc Exon Structure
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Expression
for VMAC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VMAC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACTGTCTC
About this image
See VMAC Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.620821
SABiosciences Custom PCR Arrays for VMAC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VMAC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VMAC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VMAC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VMAC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VMAC |
Orthologs
for VMAC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for VMAC gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for VMAC (if available)
TreeFam Gene Tree for VMAC (if available) |
Paralogs
for VMAC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VMAC gene
- ENSG000002673142
VMAC for paralogs About GeneDecksing
|
Genomic Variants
for VMAC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for VMAC (5904852 - 5910864 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for VMAC
1 Indel: 67448 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VMAC |
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Disorders
/ Diseases
for VMAC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VMAC for disorders About GeneDecksing
1  disease for VMAC: About MalaCardsmitral valve stenosis
Export disorders for VMAC gene to outside databases
|
Publications
for VMAC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VMAC gene integrated from 9 sources:
(articles sorted by number of sources associating them with VMAC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Vmac: a novel protein associated with vimentin-type intermediate filament in podocytes of rat kidney. (PubMed id 14985129)1, 3 Yamamoto Y....Takai Y. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for VMAC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing VMAC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing VMAC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VMAC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VMAC | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for VMAC gene:
Search GeneIP for patents involving VMAC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VMAC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VMAC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VMAC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VMAC | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for VMAC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VMAC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VMAC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VMAC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VMAC | | OriGene Custom Protein Services for VMAC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VMAC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VMAC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VMAC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VMAC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VMAC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VMAC |
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| | | | Search Tocris compounds for VMAC |
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 | | | VMAC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VMAC |
|  |  |  | | | | Search ThermoFisher Antibodies for VMAC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VMAC |
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