Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VMAC Gene

Aliases for VMAC Gene

  • Vimentin Type Intermediate Filament Associated Coiled-Coil Protein 2 3 5

External Ids for VMAC Gene

Previous GeneCards Identifiers for VMAC Gene

  • GC19P005855
  • GC19P005664

Summaries for VMAC Gene

GeneCards Summary for VMAC Gene

VMAC (Vimentin Type Intermediate Filament Associated Coiled-Coil Protein) is a Protein Coding gene. An important paralog of this gene is ENSG00000267314.

Additional gene information for VMAC Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VMAC Gene

Genomics for VMAC Gene

Regulatory Elements for VMAC Gene

Enhancers for VMAC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H005689 1.2 ENCODE 55 -212.7 -212740 4 ZFP64 DMAP1 YY1 ZNF143 ZNF548 SP3 ZC3H11A SSRP1 ZNF610 GLIS1 KHSRP DUS3L SAFB ENSG00000267571 SNRPEP4 SAFB2 RANBP3 VMAC PTPRS GTF2F1
GH19H005308 1.3 Ensembl ENCODE 45.4 -595.7 -595665 1 HNRNPUL1 FEZF1 ZNF2 ZNF302 SP3 REST ZNF610 ZSCAN16 GLIS1 KDM1A DUS3L ENSG00000267030 ENSG00000267571 SAFB VMAC ENSG00000267255 RANBP3 ENSG00000267769 SAFB2 KDM4B
GH19H006527 1.4 ENCODE dbSUPER 39.6 +625.8 625803 6 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZNF766 ZNF143 ZNF207 ZNF557 KHSRP DUS3L SAFB SAFB2 SNRPEP4 ENSG00000267571 GTF2F1 RANBP3 VMAC
GH19H005956 1.9 FANTOM5 Ensembl ENCODE dbSUPER 29.1 +58.4 58412 13 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 VMAC CAPS NDUFA11 FUT5 ACSBG2 ENSG00000267571 GPR108 DUS3L FUT3 FUT6
GH19H006270 2 FANTOM5 Ensembl ENCODE dbSUPER 26.7 +370.5 370512 10 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 DUS3L ZNF557 KHSRP SNRPEP4 SAFB ENSG00000267571 VMAC ACSBG2 ALKBH7 GPR108
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VMAC on UCSC Golden Path with GeneCards custom track

Promoters for VMAC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106432 -541 2601 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for VMAC Gene

Chromosome:
19
Start:
5,904,841 bp from pter
End:
5,910,853 bp from pter
Size:
6,013 bases
Orientation:
Plus strand

Genomic View for VMAC Gene

Genes around VMAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VMAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VMAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VMAC Gene

Proteins for VMAC Gene

  • Protein details for VMAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2NL98-VMAC_HUMAN
    Recommended name:
    Vimentin-type intermediate filament-associated coiled-coil protein
    Protein Accession:
    Q2NL98
    Secondary Accessions:
    • B3KW55

    Protein attributes for VMAC Gene

    Size:
    169 amino acids
    Molecular mass:
    18348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VMAC Gene

Post-translational modifications for VMAC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VMAC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VMAC Gene

Domains & Families for VMAC Gene

Gene Families for VMAC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VMAC Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VMAC: view

No data available for UniProtKB/Swiss-Prot for VMAC Gene

Function for VMAC Gene

Phenotypes From GWAS Catalog for VMAC Gene

genes like me logo Genes that share phenotypes with VMAC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VMAC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VMAC Gene

Localization for VMAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for VMAC Gene

Cytoplasm. Note=Colocalizes with vimentin-type intermediate filaments. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VMAC gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VMAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with VMAC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for VMAC Gene

Pathways & Interactions for VMAC Gene

No Data Available

Gene Ontology (GO) - Biological Process for VMAC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VMAC Gene

Drugs & Compounds for VMAC Gene

No Compound Related Data Available

Transcripts for VMAC Gene

mRNA/cDNA for VMAC Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(186) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VMAC Gene

Vimentin-type intermediate filament associated coiled-coil protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VMAC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VMAC Gene

No ASD Table

Relevant External Links for VMAC Gene

GeneLoc Exon Structure for
VMAC
ECgene alternative splicing isoforms for
VMAC

Expression for VMAC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VMAC Gene

Protein differential expression in normal tissues from HIPED for VMAC Gene

This gene is overexpressed in Skin (37.6) and Salivary gland (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VMAC Gene



NURSA nuclear receptor signaling pathways regulating expression of VMAC Gene:

VMAC

SOURCE GeneReport for Unigene cluster for VMAC Gene:

Hs.620821
genes like me logo Genes that share expression patterns with VMAC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VMAC Gene

Orthologs for VMAC Gene

This gene was present in the common ancestor of chordates.

Orthologs for VMAC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VMAC 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia VMAC 33
  • 89.74 (n)
-- 34
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia VMAC 33 34
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Vmac 33
  • 79.49 (n)
mouse
(Mus musculus)
Mammalia Vmac 33 16 34
  • 78.9 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC570934 33
  • 57.79 (n)
VMAC 34
  • 46 (a)
OneToMany
Species where no ortholog for VMAC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VMAC Gene

ENSEMBL:
Gene Tree for VMAC (if available)
TreeFam:
Gene Tree for VMAC (if available)

Paralogs for VMAC Gene

Paralogs for VMAC Gene

genes like me logo Genes that share paralogs with VMAC: view

Variants for VMAC Gene

Sequence variations from dbSNP and Humsavar for VMAC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1056987 Likely benign 5,903,925(-) TGGGG(A/G)TGCAC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs8108064 Likely benign 5,903,796(+) CTCGG(G/T)CTGCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs115530541 Uncertain significance 5,903,942(+) TTCCT(A/G)GAGGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs375356874 Uncertain significance 5,903,679(+) ATATC(A/C)CAGTA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs550697802 Uncertain significance 5,903,851(+) TTATT(C/G)ATAGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for VMAC Gene

Variant ID Type Subtype PubMed ID
esv27099 CNV loss 19812545

Variation tolerance for VMAC Gene

Gene Damage Index Score: 3.62; 56.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VMAC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VMAC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VMAC Gene

Disorders for VMAC Gene

Relevant External Links for VMAC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VMAC

No disorders were found for VMAC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VMAC Gene

Publications for VMAC Gene

  1. Vmac: a novel protein associated with vimentin-type intermediate filament in podocytes of rat kidney. (PMID: 14985129) Yamamoto Y … Takai Y (Biochemical and biophysical research communications 2004) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for VMAC Gene

Sources for VMAC Gene

Content
Loading form....