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VMAC Gene

protein-coding   GIFtS: 28

GC19P005855
vimentin-type IF-associated coiled-coil protein
symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC131658 2
Descriptions
vimentin-type IF-associated coiled-coil protein 2
External Ids
Entrez Gene: 4006732
UniProtKB: Q2NL983
Search outside databases for aliases for VMAC gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VMAC gene  

Entrez Gene cytogenetic band: 19p13.3   

VMAC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P005855:     (about GC identifiers)

Start:
5,855,894 bp from pter
End:
5,861,263 bp from pter
Size:
5,370 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000019.8  NT_011255.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VMAC_HUMAN, Q2NL98 (See protein sequence)
Recommended Name: Vimentin-type intermediate filament-associated coiled-coil protein  
Size: 169 amino acids; 18348 Da
Subcellular location: Cytoplasm (By similarity). Note=Colocalizes with vimentin-type intermediate
filaments (By similarity)
Secondary accessions: B3KW55

REFSEQ proteins: NP_001017921.1  
Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
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Antibodies for VMAC: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for VMAC

Assays for VMAC: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q2NL98

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (VMAC)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001017921

              Applied Biosystems Silencer® siRNAs for VMAC

              Sigma-Aldrich siRNA for VMAC  
                     Sigma-Aldrich shRNA for VMAC  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017921
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017921
                                 untagged cDNA clone in CMV expression vector: NM_001017921 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001017921

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VMAC

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (VMAC)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001017921

              Sigma-Aldrich siRNA for VMAC  
                     Sigma-Aldrich shRNA for VMAC  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001017921  

REFSEQ mRNAs for VMAC gene: 

NM_001017921.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001017921  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017921
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017921
                                 untagged cDNA clone in CMV expression vector: NM_001017921 

Additional cDNA sequence: 

AK124162.1 BC110802.1 

2 DOTS entries:

DT.101970284  DT.312821 

24/186 AceView cDNA sequences (see all 186 ):

BM725337 BM712749 CA396674 CR623055 CK821926 BE396135 BQ436748 AW513409 
AI628545 BG950416 AI624988 AI613142 BQ673321 AW510425 AW151211 BU689238 
BM716373 BG767590 CR601253 BQ673294 BM699638 AI924700 AI560810 CF128141 

highest scoring ESTs for VMAC:

AK124162 BF127674 BF686372 BG764787 BG765733 BQ673294 BQ673321 CB142386 BC110802 BF858317 

Unigene Cluster for VMAC:

Vimentin-type IF-associated coiled-coil protein
Hs.620821  [show with all ESTs]
Unigene Representative Sequence: AK124162


GeneLoc Exon Structure

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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VMAC expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for VMAC

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.620821
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for VMAC gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC6117531   -- similar to vimentin-type IF-associated coiled-coil more 89.74(n)
89.35(a)
611753  XM_849465.1  XP_854558.1 
chimpanzee
(Pan troglodytes)
LOC4556291   -- vimentin-type IF-associated coiled-coil protein 99.61(n)
99.41(a)
455629  XM_512306.2  XP_512306.1 
cow
(Bos taurus)
VMAC1   -- vimentin-type IF-associated coiled-coil protein 86.35(n)
82.53(a)
515212  XM_593195.3  XP_593195.2 
rat
(Rattus norvegicus)
Vmac1   -- vimentin-type intermediate filament associated coiled-coil more 79.49(n)
75.74(a)
363327  NM_001001720.1  NP_001001720.1 
mouse
(Mus musculus)
AI6622501, 5 175
expressed sequence AI6622501, 5 78.9(n)1
76.33(a)1
1066391  NM_178926.21  NP_849257.11 
 AI6622505  AI8537705  (see all 14)
About this table        Species with no ortholog for VMAC
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/46 NCBI SNPs in VMAC are shown (see all 46 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 32)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs72605781,2
A,C,F,H5861095(+) TTCAGA/GATGGC 1 -- ut314Minor allele frequency- G:0.40EU EA WA 404
--
rs4204581,2
A,C,F5860780(-) CTTACG/ACCTAT 1 -- ut314Minor allele frequency- A:0.31EA NA 166
--
rs48078231,2
A,C5861513(+) gaccaC/Gcctgg 1 -- ng310--------
rs104193221,2
H5860871(+) CTCCTT/CGTTTC 1 -- ut313Minor allele frequency- C:0.00EU EA 298
rs3868031,2
C,F,H5858405(+) acgtgT/Gtgtgg 1 -- int18Minor allele frequency- G:0.06EU EA WA 818
--
rs4834661,2
A,C5859161(+) accagC/Tctggc 1 -- int10--------
--
rs4166761,2
C,F5858358(+) tgtgtC/Ttccac 1 -- int13Minor allele frequency- T:0.03NA 142
--
rs5390521,2
A,C5857881(-) tttttA/Gtattt 1 -- int10--------
--
rs4479801,2
A,C5859448(-) GGGTTG/TCACCA 1 -- int10--------
--
rs5427671,2
A,C5857450(-) gaagaC/Tgaatg 1 -- int10--------
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HapMap Linkage Disequilibrium images for VMAC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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5 PubMed articles for VMAC gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 400673 AceView: CAPSandVMAC euGenes: HUgn400673
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for VMAC:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VMAC-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for VMAC Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for VMAC Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search Novus for antibodies for VMAC

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