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Aliases for VMAC Gene

Aliases for VMAC Gene

  • Vimentin-Type Intermediate Filament Associated Coiled-Coil Protein 2 3 5

External Ids for VMAC Gene

Previous GeneCards Identifiers for VMAC Gene

  • GC19P005855
  • GC19P005664

Summaries for VMAC Gene

GeneCards Summary for VMAC Gene

VMAC (Vimentin-Type Intermediate Filament Associated Coiled-Coil Protein) is a Protein Coding gene. An important paralog of this gene is ENSG00000267314.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VMAC Gene

Genomics for VMAC Gene

Regulatory Elements for VMAC Gene

Enhancers for VMAC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around VMAC on UCSC Golden Path with GeneCards custom track

Promoters for VMAC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VMAC on UCSC Golden Path with GeneCards custom track

Genomic Location for VMAC Gene

5,904,841 bp from pter
5,910,853 bp from pter
6,013 bases
Plus strand

Genomic View for VMAC Gene

Genes around VMAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VMAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VMAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VMAC Gene

Proteins for VMAC Gene

  • Protein details for VMAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vimentin-type intermediate filament-associated coiled-coil protein
    Protein Accession:
    Secondary Accessions:
    • B3KW55

    Protein attributes for VMAC Gene

    169 amino acids
    Molecular mass:
    18348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VMAC Gene

Post-translational modifications for VMAC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VMAC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VMAC Gene

Domains & Families for VMAC Gene

Protein Domains for VMAC Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VMAC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for VMAC Gene

Function for VMAC Gene

genes like me logo Genes that share phenotypes with VMAC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VMAC Gene

Localization for VMAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for VMAC Gene

Cytoplasm. Note=Colocalizes with vimentin-type intermediate filaments. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for VMAC Gene COMPARTMENTS Subcellular localization image for VMAC gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VMAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0045098 type III intermediate filament IEA --
genes like me logo Genes that share ontologies with VMAC: view

Pathways & Interactions for VMAC Gene

SuperPathways for VMAC Gene

No Data Available

Interacting Proteins for VMAC Gene

Selected Interacting proteins: Q2NL98-VMAC_HUMAN for VMAC Gene via IID

Gene Ontology (GO) - Biological Process for VMAC Gene


No data available for Pathways by source and SIGNOR curated interactions for VMAC Gene

Drugs & Compounds for VMAC Gene

No Compound Related Data Available

Transcripts for VMAC Gene

mRNA/cDNA for VMAC Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(186) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VMAC Gene

Vimentin-type intermediate filament associated coiled-coil protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VMAC Gene

No ASD Table

Relevant External Links for VMAC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VMAC Gene

mRNA expression in normal human tissues for VMAC Gene

Protein differential expression in normal tissues from HIPED for VMAC Gene

This gene is overexpressed in Skin (37.6) and Salivary gland (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VMAC Gene

NURSA nuclear receptor signaling pathways regulating expression of VMAC Gene:


SOURCE GeneReport for Unigene cluster for VMAC Gene:

genes like me logo Genes that share expression patterns with VMAC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for VMAC Gene

Orthologs for VMAC Gene

This gene was present in the common ancestor of chordates.

Orthologs for VMAC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VMAC 34
  • 86.35 (n)
  • 82.53 (a)
  • 83 (a)
(Canis familiaris)
Mammalia VMAC 34
  • 89.74 (n)
  • 89.35 (a)
-- 35
  • 89 (a)
(Mus musculus)
Mammalia Vmac 34
  • 78.9 (n)
  • 76.33 (a)
Vmac 16
Vmac 35
  • 74 (a)
(Pan troglodytes)
Mammalia VMAC 34
  • 99.61 (n)
  • 99.41 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Vmac 34
  • 79.49 (n)
  • 75.74 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
(Danio rerio)
Actinopterygii LOC570934 34
  • 57.79 (n)
  • 49.7 (a)
  • 46 (a)
Species where no ortholog for VMAC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VMAC Gene

Gene Tree for VMAC (if available)
Gene Tree for VMAC (if available)

Paralogs for VMAC Gene

Paralogs for VMAC Gene

genes like me logo Genes that share paralogs with VMAC: view

Variants for VMAC Gene

Sequence variations from dbSNP and Humsavar for VMAC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10682358 -- 5,908,657(+) AATAA(-/TAA)AAACA intron-variant
rs11365263 -- 5,908,616(+) GTCTC(-/A)AAAAA intron-variant
rs11393158 -- 5,910,004(+) ACTCA(-/G)GGAAC utr-variant-3-prime
rs11666136 -- 5,908,189(+) aaata(A/C)aaaaa intron-variant
rs33945799 -- 5,906,135(+) AAAAA(-/A/AA)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VMAC Gene

Variant ID Type Subtype PubMed ID
esv27099 CNV loss 19812545

Variation tolerance for VMAC Gene

Gene Damage Index Score: 3.62; 56.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VMAC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VMAC Gene

Disorders for VMAC Gene

Relevant External Links for VMAC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VMAC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VMAC Gene

Publications for VMAC Gene

  1. Vmac: a novel protein associated with vimentin-type intermediate filament in podocytes of rat kidney. (PMID: 14985129) Yamamoto Y. … Takai Y. (Biochem. Biophys. Res. Commun. 2004) 2 3 65
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for VMAC Gene

Sources for VMAC Gene