V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

VLDLR Gene

protein-coding GIFtS: 63

GC09P002611

very low density lipoprotein receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CHRMQ1 ^², ⁵
FLJ35024 ^²
OTTHUMP00000020982 ^²
OTTHUMP00000020983 ^²
VLDL-R ^³
VLDLRCH ^²

Descriptions
VLDL receptor ^³
Very low-density lipoprotein receptor ^²
very low density lipoprotein receptor ^²

External Ids
HGNC: 12698¹
Entrez Gene: 7436²
UniProtKB: P98155³
Ensembl: ENSG00000147852⁷

Search outside databases for aliases for VLDLR gene

Previous GC identifers: GC09P002776 GC09P002603 GC09P002612

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VLDLR_HUMAN, P98155

Function: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the

receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces

tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VLDLR gene

Entrez Gene cytogenetic band: 9p24 Ensembl cytogenetic band: 9p24.2 HGNC cytogenetic band: 9p24

VLDLR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P002611: (about GC identifiers)

Start:	2,611,793 bp from pter
End:	2,644,485 bp from pter
Size:	32,693 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VLDLR_HUMAN, P98155 (See protein sequence)

Recommended Name: Very low-density lipoprotein receptor precursor

Size: 873 amino acids; 96098 Da

Subunit: Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with

SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses

(HRVs); binds protein VP1 through the second and third LDL-receptor class A domains

Subcellular location: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit;

Single-pass type I membrane protein

PDB structure from and Proteopedia :

1V9U (3D)

3DPR (3D)

Secondary accessions: Q5VVF6

Alternative splicing: 2 isoforms: P98155-1 P98155-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001018066.1 NP_003374.3

ENSEMBL proteins:

ENSP00000276891 ENSP00000371566 ENSP00000371528 ENSP00000371524 ENSP00000371532 ENSP00000371531

ENSP00000381016

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (VLDL Receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IDA	15082773
GO:0005886	plasma membrane	TAS	10380922
GO:0005905	coated pit	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0034361	very-low-density lipoprotein particle	IEA	--

About this table

Antibodies for VLDLR:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for VLDLR
	R&D Systems Antibodies for VLDLR
	Antibodies from Abcam (VLDL Receptor), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for VLDLR

Assays for VLDLR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P98155

ProtoNet protein and cluster: P98155

4 Blocks protein families:

IPB000033 Low-density lipoprotein receptor

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001881 EGF-like calcium-binding

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: VLDLR_HUMAN, P98155

Similarity: Contains 3 EGF-like domains

Similarity: Contains 8 LDL-receptor class A domains

Similarity: Contains 6 LDL-receptor class B repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VLDLR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VLDLR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003383

Applied Biosystems Silencer® siRNAs for VLDLR

Sigma-Aldrich siRNA and siRNA Panels for VLDLR

Sigma-Aldrich shRNA for VLDLR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001018056
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001018056
untagged cDNA clones in CMV expression vector (see all 2): NM_001018056

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003383

UniProtKB/Swiss-Prot: VLDLR_HUMAN, P98155

Function: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the

receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces

tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity)

Genatlas biochemistry entry for VLDLR:

very low density lipoprotein/ApoE receptor,containing a CGG repeat in 5'utr,(may be a

susceptibility gene for late onset senile Alzheimer disease)

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vldlr):

	adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism
lethality-postnatal	nervous system	pigmentation	vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005041	low-density lipoprotein receptor activity	TAS	10380922
GO:0005509	calcium ion binding	IEA	--
GO:0030229	very-low-density lipoprotein receptor activity	IDA	8083232

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for VLDLR (Your Favorite Gene powered by Ingenuity)

FXR/RXR Activation

GeneDecks VLDLR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for VLDLR

5/30 Interacting proteins for VLDLR (ENSP00000371532³) via UniProtKB, MINT, and/or STRING (see all 30 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RELN	ENSP00000373767³	STRING (score=.999)
APOE	ENSP00000252486³	STRING (score=.986)
PAFAH1B1	ENSP00000006951³	STRING (score=.974)
DAB1	ENSP00000360279³	STRING (score=.972)
FYN	ENSP00000357656³	STRING (score=.97)

About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0006869	lipid transport	IEA	--
GO:0006897	endocytosis	IEA	--
GO:0007165	signal transduction	TAS	10380922
GO:0007399	nervous system development	TAS	10380922

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VLDLR
8 Novoseek chemical compound relationships for VLDLR gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol	38.61	15	11839845 (3), 15010349 (1), 17685481 (1), 7918302 (1) (see all 10)
lipid	36.77	16	10488949 (2), 15863833 (2), 9410893 (1), 9409253 (1) (see all 9)
sterol	18.39	3	7828550 (1), 10488949 (1)
fatty acid	14.25	2	16957181 (1), 9264123 (1)
triacylglycerol	8.42	3	7925422 (1), 12840916 (1)
phosphoinositide	1.48	1	15883038 (1)
phospholipid	0.00	1	8409765 (1)
tyrosine	0.00	2	11854295 (1), 15883038 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VLDLR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (VLDLR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003383

Sigma-Aldrich siRNA and siRNA Panels for VLDLR

Sigma-Aldrich shRNA for VLDLR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001018056 NM_003383

REFSEQ mRNAs for VLDLR gene (2 alternative transcripts):

NM_001018056.1 NM_003383.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001018056 NM_003383

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001018056
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001018056
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001018056

Additional cDNA sequence:

AB208822.1 AK092381.1 AK095744.1 AK289527.1 BC136562.1 BC142653.1 BC144245.1 CR599863.1

CR620590.1 D16493.1 D16494.1 L20470.1 L22431.1 S73849.1

11 DOTS entries:

DT.95162785 DT.445283 DT.95162788 DT.121199610 DT.95162786 DT.100783166 DT.40202618 DT.92007717

DT.445284 DT.95162789 DT.121199462

24/110 AceView cDNA sequences (see all 110 ):

BM810111 BM558836 AU125996 AU132660 D16493 T07960 AK092381 BM987917

BU634296 CN479223 BU633666 AA758887 D16494 AU130860 AX747508 BE742166

BX508834 AA461614 CR599863 BE348247 AA357050 BU677670 BE733087 CR620590

highest scoring ESTs for VLDLR:

AA247557 AA758887 AA971809 AA993057 AI050969 AI149365 AI288314 AI299085 AI352229 AI392663

Unigene Cluster for VLDLR:

Very low density lipoprotein receptor

Hs.370422 [show with all ESTs]

Unigene Representative Sequence: L20470

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for VLDLR (see all 9 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16a	·	16b	·
SP1:													-																										-		-
SP2:													-
SP3:
SP4:																																									-
SP5:																																									-

ExUns:	16c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for VLDLR

7 Ensembl transcripts including schematic representations:

ENST00000276891 ENST00000382131 ENST00000382096 ENST00000382092 ENST00000382100 ENST00000382099

ENST00000397921

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VLDLR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VLDLR

¹ / ² / ³

3 probe-sets matching VLDLR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36873_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D16532	0.20	1.00	0.72	1
209822_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L22431	0.80	1.00	0.91	1
209822_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks VLDLR for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACTTTGACA

SOURCE GeneReport for Unigene cluster: Hs.370422
Expression variation in blood from EXPOLDB for VLDLR
UniProtKB/Swiss-Prot: VLDLR_HUMAN, P98155
Tissue specificity: Abundant in heart and skeletal muscle; also ovary and kidney; not in liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VLDLR gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VLDLR¹	--	very low density lipoprotein receptor	91.56(n) 95.88(a)	476336 XM_533538.2 XP_533538.2
chimpanzee (Pan troglodytes)	VLDLR¹	--	very low density lipoprotein receptor	98.43(n) 98.12(a)	464967 XM_520460.2 XP_520460.2
cow (Bos taurus)	vldlr¹	--	very low density lipoprotein receptor	91.16(n) 95.15(a)	282123 NM_174489.2 NP_776914.1
rat (Rattus norvegicus)	Vldlr¹	--	very low density lipoprotein receptor	90.95(n) 95.88(a)	25696 NM_013155.1 NP_037287.1
mouse (Mus musculus)	Vldlr^{1, 5}	19 (20.00 cM)⁵	very low density lipoprotein receptor^{1, 5}	90.87(n)¹ 95.88(a)¹	22359¹ NM_013703.1¹ NP_038731.1¹ AA408956⁵ AF026064⁵ (see all 24)

About this table Species with no ortholog for VLDLR

ENSEMBL Gene Tree for VLDLR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VLDLR gene

LRP2² LDLR² LRP8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/335 NCBI SNPs in VLDLR are shown (see all 335 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 258)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1454626^1,2	A,C,F,H,O	2611030(+)	`ACCAGA/CCACAA`	2	--	ng5¹		7	MN NS EU EA WA	680
	rs8210^1,2	A,C,F,H	2644419(+)	`AAGACT/CGAGTG`	2	--	ut3¹		15	NS MN NA EU EA WA	946
--	rs7852409^1,2	A,C,F,H	2611482(+)	`GCACCG/CGGGAT`	2	--	ng5¹		6	NS EU EA WA	490
	rs3421^1,2	C,F,H	2644048(+)	`TTCTTG/ATCCAC`	2	--	ut3¹		10	MN NA EU EA WA NS	836
	rs12057080^1,2	C,F,H	2609915(+)	`GCTTGT/AAGTAT`	2	--	ng5¹		6	EU EA WA NS	474
	rs10967349^1,2	C,F,H	2644402(+)	`CTCAAT/CGGAGG`	2	--	ut3¹ ese³		6	NS EU EA WA	508
	rs7043199^1,2	A,C,F	2611145(+)	`CCCACT/ATTTGA`	2	--	ng5¹		2	NS	82
	rs6149^1,2	C,F,H	2625545(+)	`ACTGTG/ATTGAC`	2	I/V	mis¹		20	MN NA NS EU EA WA	1850
	rs10967202^1,2	F,H	2609870(+)	`ACACGT/CTTTTC`	2	--	ng5¹		4	EU EA WA	398
--	rs12379259^1,2	C,F	2612121(+)	`GAAGGG/ACTGGT`	2	--	ut5¹ ese³		2	NS	90

About this table

HapMap Linkage Disequilibrium images for VLDLR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 192977 disorders: 224050

UniProtKB/Swiss-Prot: VLDLR_HUMAN, P98155

Deletions involving VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia

(VLDLRCH) [MIM:224050]; also known as dysequilibrium syndrome (DES) or non-progressive cerebellar

disorder with mental retardation. VLDLRCH is a syndrome characterized by moderate-to-profound

mental retardation, delayed ambulation, and predominantly truncal ataxia. Additional features

include strabismus and pesplanus in the majority of patients, seizures in 40% of patients, and

short stature in 15% of patients. Magnetic resonance imaging demonstrates inferior cerebellar

hypoplasia and mild cortical gyral simplification

10/15 Novoseek disease relationships for VLDLR gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cerebellar hypoplasia	63.38	2	18043714 (1), 18364738 (1)
alzheimers disease	44.22	13	8786409 (2), 9562467 (2), 8761993 (2), 9577654 (1) (see all 9)
hypertriglyceridemia	40.51	2	16478678 (1), 11790777 (1)
senile plaques	29.00	3	8786409 (2), 11743951 (1)
atherosclerosis	28.98	4	19224153 (1), 8669483 (1), 11254915 (1)
adenocarcinoma gastric	17.20	3	10629142 (2), 15884130 (1)
autistic	11.09	2	15820235 (1), 12363388 (1)
tumors	3.60	2	16715143 (1), 10629142 (1)
cancer	1.76	4	9346319 (2), 16715143 (1), 10629142 (1)
renal disease	0.00	1	9430847 (1)

About this table

GeneTests: VLDLR

VLDLR-Associated Cerebellar Hypoplasia

Human Gene Mutation Database: VLDLR
Genetic Association Database: VLDLR
Human Genome Epidemiology Navigator: VLDLR (10 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/180 PubMed articles for VLDLR gene (see all 180 ):

Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. (PubMed id 8294473)^{1, 2, 3, 4} Sakai J.... Yamamoto T. (1994)
Human very-low-density lipoprotein receptor complementary DNA and deduced amino acid sequence and localization of its gene (VLDLR) to chromosome band 9p24 by fluorescence in situ hybridization. (PubMed id 8020981)^{1, 3, 4} Oka K.... Chan L. (1994)
Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PubMed id 16384981)^{1, 3, 6} Haines J.L....Pericak-Vance M.A. (2006)
Association of polymorphisms in CYP17A1, MTP, and VLDLR with bone mineral density in community-dwelling Japanese women and men. (PubMed id 15953542)^{1, 3, 6} Yamada Y....Shimokata H. (2005)
A cellular receptor of human rhinovirus type 2, the very-low-density lipoprotein receptor, binds to two neighboring proteins of the viral capsid. (PubMed id 12857919)^{1, 3, 4} Neumann E.... Hewat E.A. (2003)
The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population. (PubMed id 11931574)^{1, 3, 6} Benes P....Vacha J. (2002)
Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia. (PubMed id 12363388)^{1, 3, 6} Akahane A....Nanko S. (2002)
VLDL receptor polymorphism, cognitive impairment, and dementia. (PubMed id 11342683)^{1, 3, 6} Helbecque N....Amouyel P. (2001)
Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. (PubMed id 16080122)^{1, 3, 4} Boycott K.M....Parboosingh J.S. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7436	HGNC: 12698	AceView: VLDLR	Ensembl:ENSG00000147852	euGenes: HUgn7436
ECgene: VLDLR	H-InvDB: VLDLR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/vldlr/

Licensable Technologies for VLDLR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VLDLR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VLDLR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VLDLR		Antibodies for VLDLR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VLDLR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (VLDLR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (VLDL Receptor)
	Antibodies (VLDL Receptor)

Search OriGene for VLDLR

Search Tocris compounds for VLDLR

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for VLDLR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
VLDLR Gene at Home site.
Version 2.41.1
server5.xennexinc.com

VLDLR Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for VLDLR

Summaries
for VLDLR

Genomic Location
for VLDLR

Proteins
for VLDLR

Protein Domains/
Families
for VLDLR

Gene Function
for VLDLR

Pathways & Interactions
for VLDLR

Drugs & Compounds
for VLDLR

Transcripts
for VLDLR

Expression
for VLDLR

Orthologs
for VLDLR

Paralogs
for VLDLR

SNPs/Variants
for VLDLR

Disorders & Mutations
for VLDLR

Medical News
for VLDLR

Publications
for VLDLR

Search for VLDLR

Genome Databases showing VLDLR

Other Databases showing VLDLR

Specialized Databases showing VLDLR

Licensable Technologies
for VLDLR

Services
for VLDLR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VLDLR Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor VLDLR

Summariesfor VLDLR

Genomic Locationfor VLDLR

Proteinsfor VLDLR

Protein Domains/Familiesfor VLDLR

Gene Functionfor VLDLR

Pathways & Interactionsfor VLDLR

Drugs & Compoundsfor VLDLR

Transcriptsfor VLDLR

Expression for VLDLR

Orthologsfor VLDLR

Paralogsfor VLDLR

SNPs/Variantsfor VLDLR

Disorders & Mutationsfor VLDLR

Medical Newsfor VLDLR

Publicationsfor VLDLR

Search for VLDLR

Genome Databases showing VLDLR

Other Databases showing VLDLR

Specialized Databases showing VLDLR

Licensable Technologiesfor VLDLR

Servicesfor VLDLR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VLDLR

Summaries
for VLDLR

Genomic Location
for VLDLR

Proteins
for VLDLR

Protein Domains/
Families
for VLDLR

Gene Function
for VLDLR

Pathways & Interactions
for VLDLR

Drugs & Compounds
for VLDLR

Transcripts
for VLDLR

Expression
for VLDLR

Orthologs
for VLDLR

Paralogs
for VLDLR

SNPs/Variants
for VLDLR

Disorders & Mutations
for VLDLR

Medical News
for VLDLR

Publications
for VLDLR

Licensable Technologies
for VLDLR

Services
for VLDLR