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VKORC1L1 Gene

protein-coding GIFtS: 43

GC07P064975

vitamin K epoxide reductase complex, subunit 1-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp762H0113 ^²

Descriptions
VKORC1-like protein 1 ^³
vitamin K epoxide reductase complex, subunit 1-like 1 ^²

External Ids
HGNC: 21492¹
Entrez Gene: 154807²
UniProtKB: Q8N0U8³
Ensembl: ENSG00000196715⁷

Search outside databases for aliases for VKORC1L1 gene

Previous GC identifers: GC07P064749 GC07P064782

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VKORC1L1 gene

Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21

VKORC1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P064975: (about GC identifiers)

Start:	64,975,692 bp from pter
End:	65,060,252 bp from pter
Size:	84,561 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 64,675,776-64,757,321

RefSeq DNA sequence:

NC_000007.12 NT_007758.11 NT_079593.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VKORL_HUMAN, Q8N0U8 (See protein sequence)

Recommended Name: Vitamin K epoxide reductase complex subunit 1-like protein 1

Size: 176 amino acids; 19836 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q6AHW9 Q6TEK6

REFSEQ proteins: NP_775788.2

ENSEMBL proteins:

ENSP00000353998

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for VKORC1L1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for VKORC1L1

Assays for VKORC1L1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8N0U8

ProtoNet protein and cluster: Q8N0U8

1 Blocks protein family: IPB012932 Vitamin K epoxide reductase

UniProtKB/Swiss-Prot: VKORL_HUMAN, Q8N0U8

Similarity: Belongs to the VKOR family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VKORC1L1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173517

Applied Biosystems Silencer® siRNAs for VKORC1L1

Sigma-Aldrich siRNA for VKORC1L1

Sigma-Aldrich shRNA for VKORC1L1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VKORC1L1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_173517
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173517
untagged cDNA clone in CMV expression vector: NM_173517

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173517

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VKORC1L1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VKORC1L1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173517

Sigma-Aldrich siRNA for VKORC1L1

Sigma-Aldrich shRNA for VKORC1L1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_173517

REFSEQ mRNAs for VKORC1L1 gene:

NM_173517.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_173517

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173517
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173517
                                 untagged cDNA clone in CMV expression vector: NM_173517

Additional cDNA sequence:

AK000750.1 AK001747.1 AK124688.1 AK289522.1 AK304077.1 AL137548.1 AY423045.1 BC007465.1

BC027734.1 BX647631.1 CR602129.1 CR627471.1

10 DOTS entries:

DT.95165985 DT.100666867 DT.311907 DT.97817879 DT.100786182 DT.100786176 DT.439413 DT.100747938

DT.100786183 DT.95180966

1 AceView cDNA sequence:

AK055860

highest scoring ESTs for VKORC1L1:

AI432185 AI761553 AA029103 AA029993 AA056419 AA081649 AA248474 AA306581 AA327128 AA343194

Unigene Cluster for VKORC1L1:

Vitamin K epoxide reductase complex, subunit 1-like 1

Hs.427232 [show with all ESTs]

Unigene Representative Sequence: CR627471

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000360768

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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VKORC1L1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VKORC1L1

¹ / ² / ³

7 probe-sets matching VKORC1L1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43985_at²^{, 3}	U95-B	1	1.00	1.00	0.70	0.94	AI432185	1.00	1.00	1.00	1
86501_at²^{, 3}	U95-E	1	1.00	1.00	0.74	1.05	AI761553	1.00	1.00	1.00	1
45218_at²^{, 3}	U95-B	1	1.00	1.00	0.82	1.23	AA918969	0.60	1.00	0.82	1
75257_at²^{, 3}	U95-E	2	1.00	0.94	0.89	0.80	AI858057	0.60	1.00	0.82	1
224881_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AV724827	0.40	1.00	0.76	1
224881_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553679_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGCGGCAC

SOURCE GeneReport for Unigene cluster: Hs.427232

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for VKORC1L1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VKORC1L1¹	--	vitamin K epoxide reductase complex, subunit 1-like more	94.32(n) 97.73(a)	606915 XM_843392.1 XP_848485.1
chimpanzee (Pan troglodytes)	VKORC1L1¹	--	vitamin K epoxide reductase complex, subunit 1-like more	100(n) 100(a)	472396 XM_527770.2 XP_527770.2
cow (Bos taurus)	VKORC1L1¹	--	vitamin K epoxide reductase complex, subunit 1-like more	89.39(n) 91.48(a)	506318 XM_582748.3 XP_582748.3
rat (Rattus norvegicus)	Vkorc1l1¹	--	vitamin K epoxide reductase complex, subunit 1-like more	92.99(n) 97.16(a)	399684 NM_203338.1 NP_976083.1
mouse (Mus musculus)	Vkorc1l1^{1, 5}	5⁵	vitamin K epoxide reductase complex, subunit 1-like more^{1, 5}	92.05(n)¹ 97.16(a)¹	69568¹ NM_027121.3¹ NP_081397.1¹ AI465489⁵ AK009497⁵ (see all 13)

About this table Species with no ortholog for VKORC1L1

ENSEMBL Gene Tree for VKORC1L1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for VKORC1L1 gene

VKORC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/371 NCBI SNPs in VKORC1L1 are shown (see all 371 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs11770828^1,2	A,F,H	64974282(+)	`agcccA/Gtggaa`	1	--	ng5¹		2	EA	178
	rs12538430^1,2	C,F,H	65057623(+)	`ATTTTT/CAGGTA`	1	--	ng3¹		6	EU EA WA NA	602
--	rs10259772^1,2	H	64974568(+)	`AACTAT/CGTAAG`	1	--	ng5¹		4	EU EA WA	412
--	rs7791814^1,2	A,C,F,H	65002924(+)	`GTATAT/CGTATA`	1	--	int¹		4	EU EA WA	418
--	rs10950018^1,2	A,C,F,H	64991059(+)	`GTGAGC/G/TGGGGT`	1	--	int¹		1	WA	120
--	rs7786356^1,2	A,C,F,H	65042610(+)	`cctagC/Gtaatt`	1	--	int¹		4	EU EA WA	404
	rs10950022^1,2	A,C,F,H	65013891(+)	`atataC/Tacctc`	1	--	int¹		4	EU EA WA	418
	rs1917563^1,2	A,C,F,H	65053082(+)	`aatagA/Gtaatg`	1	--	int¹		12	EU EA WA NA	1050
	rs7784623^1,2	A,C,F,H	65032469(+)	`taaatG/Tatatt`	1	--	int¹		4	EU EA WA	418
	rs10807697^1,2	A,C,F,H	65053605(+)	`tagcaG/Atttcc`	1	--	int¹		4	EU EA WA	416

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HapMap Linkage Disequilibrium images for VKORC1L1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608838

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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6 PubMed articles for VKORC1L1 gene:

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. (PubMed id 14765194)^{3, 4} Rost S.... Oldenburg J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
No association between vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) and the variability of warfarin dose requirement in a Japanese patient population. (PubMed id 17996924)^{1, 3} Yin T....Miyata T. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 154807	HGNC: 21492	AceView: VKORC1L1.2	Ensembl:ENSG00000196715	euGenes: HUgn154807
ECgene: VKORC1L1	H-InvDB: VKORC1L1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for VKORC1L1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for VKORC1L1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VKORC1L1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VKORC1L1		Browse antibodies at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search OriGene for VKORC1L1

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Search Novus for antibodies for VKORC1L1

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VKORC1L1 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for VKORC1L1

Summaries
for VKORC1L1

Genomic Location
for VKORC1L1

Proteins
for VKORC1L1

Protein Domains/
Families
for VKORC1L1

Gene Function
for VKORC1L1

Pathways & Interactions
for VKORC1L1

Drugs & Compounds
for VKORC1L1

Transcripts
for VKORC1L1

Expression
for VKORC1L1

Orthologs
for VKORC1L1

Paralogs
for VKORC1L1

SNPs/Variants
for VKORC1L1

Disorders & Mutations
for VKORC1L1

Medical News
for VKORC1L1

Publications
for VKORC1L1

Search for VKORC1L1

Genome Databases showing VKORC1L1

Other Databases showing VKORC1L1

Specialized Databases showing VKORC1L1

Licensable Technologies
for VKORC1L1

Services
for VKORC1L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VKORC1L1 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor VKORC1L1

Summariesfor VKORC1L1

Genomic Locationfor VKORC1L1

Proteinsfor VKORC1L1

Protein Domains/Familiesfor VKORC1L1

Gene Functionfor VKORC1L1

Pathways & Interactionsfor VKORC1L1

Drugs & Compoundsfor VKORC1L1

Transcriptsfor VKORC1L1

Expression for VKORC1L1

Orthologsfor VKORC1L1

Paralogsfor VKORC1L1

SNPs/Variantsfor VKORC1L1

Disorders & Mutationsfor VKORC1L1

Medical Newsfor VKORC1L1

Publicationsfor VKORC1L1

Search for VKORC1L1

Genome Databases showing VKORC1L1

Other Databases showing VKORC1L1

Specialized Databases showing VKORC1L1

Licensable Technologiesfor VKORC1L1

Servicesfor VKORC1L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VKORC1L1

Summaries
for VKORC1L1

Genomic Location
for VKORC1L1

Proteins
for VKORC1L1

Protein Domains/
Families
for VKORC1L1

Gene Function
for VKORC1L1

Pathways & Interactions
for VKORC1L1

Drugs & Compounds
for VKORC1L1

Transcripts
for VKORC1L1

Expression
for VKORC1L1

Orthologs
for VKORC1L1

Paralogs
for VKORC1L1

SNPs/Variants
for VKORC1L1

Disorders & Mutations
for VKORC1L1

Medical News
for VKORC1L1

Publications
for VKORC1L1

Licensable Technologies
for VKORC1L1

Services
for VKORC1L1