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Aliases for VKORC1L1 Gene

Aliases for VKORC1L1 Gene

  • Vitamin K Epoxide Reductase Complex Subunit 1 Like 1 2 3 5
  • VKORC1-Like Protein 1 4
  • EC 1.17.4.4 4

External Ids for VKORC1L1 Gene

Previous GeneCards Identifiers for VKORC1L1 Gene

  • GC07P064749
  • GC07P064782
  • GC07P064975
  • GC07P065338
  • GC07P061601
  • GC07P065874

Summaries for VKORC1L1 Gene

Entrez Gene Summary for VKORC1L1 Gene

  • This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]

GeneCards Summary for VKORC1L1 Gene

VKORC1L1 (Vitamin K Epoxide Reductase Complex Subunit 1 Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include quinone binding and vitamin-K-epoxide reductase (warfarin-sensitive) activity.

UniProtKB/Swiss-Prot for VKORC1L1 Gene

  • Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VKORC1L1 Gene

Genomics for VKORC1L1 Gene

Regulatory Elements for VKORC1L1 Gene

Enhancers for VKORC1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F066033 1.4 Ensembl ENCODE 36 +197.6 197588 1.4 CEBPB EP300 RAD21 ZNF664 JUND MAFF ATF3 CEBPA ZBTB33 MAFK VKORC1L1 RABGEF1 TPST1 LOC100996437 ENSG00000229886 LOC105375336
GH07F065770 0.9 ENCODE 35.4 -65.4 -65423 1.4 HDGF PKNOX1 ATF1 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF48 LOC100996437 VKORC1L1 LOC84214 GTF2IP5 LOC441242
GH07F066016 0.4 ENCODE 35.3 +179.8 179833 0.3 PKNOX1 TAL1 JUN GATA3 CTBP1 SCRT2 FOS SMARCE1 RFX1 RNF2 VKORC1L1 GC07P066024 ENSG00000224365
GH07F065845 0.2 ENCODE 35.2 +10.0 9988 1.0 ARID1B BCOR ZNF316 GATA3 ZNF366 ZNF512 EMSY VKORC1L1 GC07P065841 GC07M065863 RNU6-973P
GH07F065947 0.6 Ensembl ENCODE 35.2 +110.8 110837 1.1 MXI1 ZNF384 RARA NR2F6 FOS GATAD2A RFX1 HLF NR2F1 CEBPB VKORC1L1 LOC644794 GC07P065961 PIR33872 LOC105375335
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around VKORC1L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VKORC1L1 Gene

Chromosome:
7
Start:
65,836,336 bp from pter
End:
65,959,563 bp from pter
Size:
123,228 bases
Orientation:
Plus strand

Genomic View for VKORC1L1 Gene

Genes around VKORC1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VKORC1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VKORC1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VKORC1L1 Gene

Proteins for VKORC1L1 Gene

  • Protein details for VKORC1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0U8-VKORL_HUMAN
    Recommended name:
    Vitamin K epoxide reductase complex subunit 1-like protein 1
    Protein Accession:
    Q8N0U8
    Secondary Accessions:
    • B4E222
    • E7ETM5
    • Q6AHW9
    • Q6TEK6

    Protein attributes for VKORC1L1 Gene

    Size:
    176 amino acids
    Molecular mass:
    19836 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin (coumadin).

    Alternative splice isoforms for VKORC1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VKORC1L1 Gene

Post-translational modifications for VKORC1L1 Gene

  • Ubiquitination at Lys 57 and Lys 168
  • Modification sites at PhosphoSitePlus

Other Protein References for VKORC1L1 Gene

No data available for DME Specific Peptides for VKORC1L1 Gene

Domains & Families for VKORC1L1 Gene

Protein Domains for VKORC1L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for VKORC1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N0U8

UniProtKB/Swiss-Prot:

VKORL_HUMAN :
  • Belongs to the VKOR family.
Family:
  • Belongs to the VKOR family.
genes like me logo Genes that share domains with VKORC1L1: view

No data available for Gene Families for VKORC1L1 Gene

Function for VKORC1L1 Gene

Molecular function for VKORC1L1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phylloquinone + oxidized dithiothreitol + H(2)O = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by warfarin (coumadin).
UniProtKB/Swiss-Prot Function:
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to oxidative stress induced by hydrogen peroxide treatment.

Enzyme Numbers (IUBMB) for VKORC1L1 Gene

Gene Ontology (GO) - Molecular Function for VKORC1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity IDA 21367861
GO:0048038 quinone binding IEA --
genes like me logo Genes that share ontologies with VKORC1L1: view

Phenotypes for VKORC1L1 Gene

GenomeRNAi human phenotypes for VKORC1L1:
genes like me logo Genes that share phenotypes with VKORC1L1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VKORC1L1 Gene

Localization for VKORC1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VKORC1L1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VKORC1L1 Gene COMPARTMENTS Subcellular localization image for VKORC1L1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for VKORC1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VKORC1L1: view

Pathways & Interactions for VKORC1L1 Gene

genes like me logo Genes that share pathways with VKORC1L1: view

Pathways by source for VKORC1L1 Gene

Interacting Proteins for VKORC1L1 Gene

Gene Ontology (GO) - Biological Process for VKORC1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017187 peptidyl-glutamic acid carboxylation IMP 24532791
GO:0034599 cellular response to oxidative stress IMP 21367861
GO:0042373 vitamin K metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with VKORC1L1: view

No data available for SIGNOR curated interactions for VKORC1L1 Gene

Drugs & Compounds for VKORC1L1 Gene

(2) Drugs for VKORC1L1 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra inhibitor, Target, cofactor 230
Warfarin Approved Pharma inhibitor 454
genes like me logo Genes that share compounds with VKORC1L1: view

Transcripts for VKORC1L1 Gene

mRNA/cDNA for VKORC1L1 Gene

(4) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VKORC1L1 Gene

Vitamin K epoxide reductase complex, subunit 1-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VKORC1L1 Gene

No ASD Table

Relevant External Links for VKORC1L1 Gene

GeneLoc Exon Structure for
VKORC1L1
ECgene alternative splicing isoforms for
VKORC1L1

Expression for VKORC1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VKORC1L1 Gene

Protein differential expression in normal tissues from HIPED for VKORC1L1 Gene

This gene is overexpressed in Adipocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VKORC1L1 Gene



Protein tissue co-expression partners for VKORC1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VKORC1L1 Gene:

VKORC1L1

SOURCE GeneReport for Unigene cluster for VKORC1L1 Gene:

Hs.427232
genes like me logo Genes that share expression patterns with VKORC1L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VKORC1L1 Gene

Orthologs for VKORC1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VKORC1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VKORC1L1 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia VKORC1L1 34 35
  • 94.32 (n)
rat
(Rattus norvegicus)
Mammalia Vkorc1l1 34
  • 92.99 (n)
mouse
(Mus musculus)
Mammalia Vkorc1l1 34 16 35
  • 92.05 (n)
cow
(Bos Taurus)
Mammalia VKORC1L1 34 35
  • 91.86 (n)
oppossum
(Monodelphis domestica)
Mammalia VKORC1L1 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves VKORC1L1 34 35
  • 81.82 (n)
lizard
(Anolis carolinensis)
Reptilia VKORC1L1 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vkorc1l1 34
  • 78.1 (n)
zebrafish
(Danio rerio)
Actinopterygii vkorc1l1 34 35
  • 74.29 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12700 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000543 34
  • 54.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta Vkor 35
  • 26 (a)
OneToMany
Species where no ortholog for VKORC1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VKORC1L1 Gene

ENSEMBL:
Gene Tree for VKORC1L1 (if available)
TreeFam:
Gene Tree for VKORC1L1 (if available)

Paralogs for VKORC1L1 Gene

(1) SIMAP similar genes for VKORC1L1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for VKORC1L1 Gene

genes like me logo Genes that share paralogs with VKORC1L1: view

No data available for Paralogs for VKORC1L1 Gene

Variants for VKORC1L1 Gene

Sequence variations from dbSNP and Humsavar for VKORC1L1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs193921078 Uncertain significance 65,954,262(+) TGAAC(G/T)AGGCC reference, missense, stop-gained
rs10224340 -- 65,897,782(+) ctgtt(C/T)tgaat intron-variant
rs10229176 -- 65,886,870(+) tctga(A/G)acaga intron-variant
rs10232924 -- 65,900,123(+) ggtgg(C/T)tcatg intron-variant
rs10235498 -- 65,890,791(+) accat(C/T)ctggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VKORC1L1 Gene

Variant ID Type Subtype PubMed ID
dgv6444n100 CNV gain 25217958
esv21527 CNV gain 19812545
esv2664145 CNV deletion 23128226
esv2759534 CNV gain+loss 17122850
esv2761079 CNV gain+loss 21179565
esv2764020 CNV gain+loss 21179565
esv3613491 CNV loss 21293372
esv3613492 CNV gain 21293372
esv3613493 CNV gain 21293372
nsv1020622 CNV gain 25217958
nsv1028971 CNV gain 25217958
nsv1029800 CNV loss 25217958
nsv1076916 CNV deletion 25765185
nsv1119125 CNV deletion 24896259
nsv1137585 CNV deletion 24896259
nsv966829 CNV duplication 23825009
nsv966830 CNV duplication 23825009

Variation tolerance for VKORC1L1 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.79; 83.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VKORC1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VKORC1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VKORC1L1 Gene

Disorders for VKORC1L1 Gene

Relevant External Links for VKORC1L1

Genetic Association Database (GAD)
VKORC1L1
Human Genome Epidemiology (HuGE) Navigator
VKORC1L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VKORC1L1

No disorders were found for VKORC1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VKORC1L1 Gene

Publications for VKORC1L1 Gene

  1. VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. (PMID: 23928358) Hammed A. … Lattard V. (J. Biol. Chem. 2013) 2 3 4 64
  2. Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration. (PMID: 24532791) Tie J.K. … Stafford D.W. (J. Biol. Chem. 2014) 3 4 64
  3. Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function. (PMID: 21367861) Westhofen P. … Oldenburg J. (J. Biol. Chem. 2011) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. No association between vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) and the variability of warfarin dose requirement in a Japanese patient population. (PMID: 17996924) Yin T. … Miyata T. (Thromb. Res. 2008) 3 22 64

Products for VKORC1L1 Gene

Sources for VKORC1L1 Gene

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