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Aliases & Descriptions for VKORC1L1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| VKORC1-like protein 1 3 | | vitamin K epoxide reductase complex, subunit 1-like 1 2 |
|
| | Search outside databases for aliases for VKORC1L1 genePrevious GC identifers: GC07P064749 GC07P064782 |
Summaries for VKORC1L1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for VKORC1L1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VKORC1L1 gene 
Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21VKORC1L1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P064975:
(about GC identifiers)
Start:
|
64,975,692 bp from pter |
End:
|
65,060,252 bp from pter |
Size:
|
84,561 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 64,675,776-64,757,321 |
RefSeq DNA sequence:- NC_000007.12 NT_007758.11 NT_079593.2
| Proteins for VKORC1L1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VKORL_HUMAN, Q8N0U8 (See
protein sequence)Recommended Name: Vitamin K epoxide reductase complex subunit 1-like protein 1 Size: 176 amino acids; 19836 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6AHW9 Q6TEK6REFSEQ proteins: NP_775788.2
ENSEMBL proteins: ENSP00000353998
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for VKORC1L1: Assays for VKORC1L1: | Protein
Domains/ Families for VKORC1L1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8N0U8
ProtoNet protein and cluster: Q8N0U8 1 Blocks protein family: IPB012932 Vitamin K epoxide reductase
UniProtKB/Swiss-Prot: VKORL_HUMAN, Q8N0U8Similarity: Belongs to the VKOR family | Gene Function for VKORC1L1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173517
Applied Biosystems Silencer® siRNAs for VKORC1L1
Sigma-Aldrich siRNA for VKORC1L1  Sigma-Aldrich shRNA for VKORC1L1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173517                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_173517                                  untagged cDNA clone in CMV expression vector: NM_173517 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_173517
| Pathways & Interactions for VKORC1L1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| -- |
Drugs & Compounds for VKORC1L1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VKORC1L1
|
Transcripts for VKORC1L1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173517
Sigma-Aldrich siRNA for VKORC1L1  Sigma-Aldrich shRNA for VKORC1L1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_173517 REFSEQ mRNAs for VKORC1L1 gene: NM_173517.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_173517               OriGene GFP tagged cDNA clone in CMV expression vector: NM_173517                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_173517                                  untagged cDNA clone in CMV expression vector: NM_173517  Additional cDNA sequence: AK000750.1 AK001747.1 AK124688.1 AK289522.1 AK304077.1 AL137548.1 AY423045.1 BC007465.1 BC027734.1 BX647631.1 CR602129.1 CR627471.1 10 DOTS entries: DT.95165985 DT.100666867 DT.311907 DT.97817879 DT.100786182 DT.100786176 DT.439413 DT.100747938 DT.100786183 DT.95180966 1 AceView cDNA sequence:AK055860
highest scoring ESTs for VKORC1L1:AI432185 AI761553 AA029103 AA029993 AA056419 AA081649 AA248474 AA306581 AA327128 AA343194 Unigene Cluster for VKORC1L1: Vitamin K epoxide reductase complex, subunit 1-like 1 Hs.427232 [show with all ESTs]Unigene Representative Sequence: CR627471
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000360768
|
Expression for VKORC1L1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VKORC1L1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VKORC1L1
1 / 2 / 3 7 probe-sets matching VKORC1L1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTGGCGGCAC
SOURCE GeneReport for Unigene cluster: Hs.427232
|
Orthologs for VKORC1L1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VKORC1L1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for VKORC1L1
ENSEMBL Gene Tree for VKORC1L1 | Paralogs for VKORC1L1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VKORC1L1 gene
- VKORC12
|
SNPs/Variants for VKORC1L1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VKORC1L1 (up to first 250kb)
|
Disorders & Mutations for VKORC1L1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608838
|
Medical News for VKORC1L1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VKORC1L1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for VKORC1L1 gene: |
Search for VKORC1L1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VKORC1L1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VKORC1L1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VKORC1L1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VKORC1L1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VKORC1L1:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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