VKORC1L1 Gene
protein-coding GIFtS: 48
GCID: GC07P065338
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|
vitamin K epoxide reductase complex, subunit 1-like 1
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Aliases
for VKORC1L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vitamin K Epoxide Reductase Complex, Subunit 1-Like 11 2 | | VKORC1-Like Protein 12 3 | | Vitamin K Epoxide Reductase Complex Subunit 1-Like Protein 12 |
Export aliases for VKORC1L1 gene to outside databasesPrevious GC identifers: GC07P064749 GC07P064782 GC07P064975 GC07P061601 |
Summaries
for VKORC1L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for VKORC1L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VKORC1L1 gene promoter:
Spz1 Pax-5 Tal-1 HNF-3beta C/EBPalpha HNF-4alpha1 E47 CHOP-10 FAC1 Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for VKORC1L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VKORC1L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21VKORC1L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P065338: view genomic region
(about GC identifiers)
Start:
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65,338,254 bp from pter |
End:
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65,424,530 bp from pter |
Size:
|
86,277 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 64,675,776-64,757,319 |
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Proteins
for VKORC1L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VKORL_HUMAN, Q8N0U8 (See
protein sequence)Recommended Name: Vitamin K epoxide reductase complex subunit 1-like protein 1 Size: 176 amino acids; 19836 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6AHW9 Q6TEK6Explore the universe of human proteins at neXtProt for VKORC1L1: NX_Q8N0U8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N0U8
VKORC1L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775788.2
ENSEMBL proteins: ENSP00000353998 ENSP00000403077
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
VKORC1L1 for ontologies About GeneDecksing
VKORC1L1 Antibody Products:
Assay Products for VKORC1L1: |
Protein
Domains /
Families
for VKORC1L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VKORC1L1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N0U8ProtoNet protein and cluster: Q8N0U8 1 Blocks protein family: IPB012932 Vitamin K epoxide reductase
UniProtKB/Swiss-Prot: VKORL_HUMAN, Q8N0U8Similarity: Belongs to the VKOR family |
Function
for VKORC1L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1L1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VKORC1L1 |
|
Pathways & Interactions
for VKORC1L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VKORC1L1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for VKORC1L1 (ENSP000003539984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for VKORC1L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VKORC1L1
2 HMDB Compounds for VKORC1L1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Menadione | Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49) | 58-27-5 | -- | | Warfarin | (phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarin (see all 105) | 81-81-2 | -- |
1 DrugBank Compound for VKORC1L1 About this table
Search CenterWatch for drugs/clinical trials and news about VKORC1L1 / VKORL
|
Transcripts
for VKORC1L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VKORC1L1 gene: NM_173517.3 Unigene Cluster for VKORC1L1: Vitamin K epoxide reductase complex, subunit 1-like 1 Hs.427232 [show with all ESTs]Unigene Representative Sequence: CR6274712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360768(uc003tul.3 uc011kds.2) ENST00000434382
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1L1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VKORC1L1 (NM_173517) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VKORC1L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VKORC1L1 |
Additional cDNA sequence: AK000750.1 AK001747.1 AK124688.1 AK289522.1 AK304077.1 AL137548.1 AY423045.1 BC007465.1 BC027734.1 BX647631.1 CR627471.1 10 DOTS entries: DT.95165985 DT.100666867 DT.311907 DT.97817879 DT.100786182 DT.100786176 DT.439413 DT.100747938 DT.100786183 DT.95180966 1 AceView cDNA sequence: AK055860
GeneLoc Exon Structure
|
Expression
for VKORC1L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VKORC1L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCGGCAC
About this image
See VKORC1L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VKORC1L1
SOURCE GeneReport for Unigene cluster: Hs.427232
SABiosciences Custom PCR Arrays for VKORC1L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VKORC1L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VKORC1L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VKORC1L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VKORC1L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VKORC1L1 |
Orthologs
for VKORC1L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for VKORC1L1 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
VKORC1L11 |
vitamin K epoxide reductase complex, subunit 1-like more |
81.82(n)
83.52(a) |
|
408253 NM_001001328.1 NP_001001328.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ035177.12 |
-- |
84.45(n) |
|
BJ035177.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
vkorc1l11 |
vitamin K epoxide reductase complex, subunit 1-like more |
74.29(n)
71.43(a) |
|
553717 NM_001020688.1 NP_001018524.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Vkor6 |
Vitamin-K epoxide reductase |
26(a) |
1 → many |
2R(12665870-12666499) |
ENSEMBL Gene Tree for VKORC1L1 (if available)
TreeFam Gene Tree for VKORC1L1 (if available) |
Paralogs
for VKORC1L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VKORC1L1 gene
- VKORC12 ENSG000002554392
1 SIMAP similar gene for VKORC1L1 using alignment to 2 protein entries: VKORL_HUMAN (see all proteins):VKORC1
VKORC1L1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for VKORC1L1
PGOHUM00000233344 PGOHUM00000233371 PGOHUM00000233390
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Genomic Variants
for VKORC1L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VKORC1L1 (65338254 - 65424530 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for VKORC1L1
2 CNVs: 64848 2698 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VKORC1L1 |
|
Disorders
/ Diseases
for VKORC1L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VKORC1L1 for disorders About GeneDecksing
OMIM gene information: 608838
OMIM disorders: --
1  disease for VKORC1L1: About MalaCardswarfarin resistance
Human Genome Epidemiology (HuGE) Navigator: VKORC1L1 (1 document)
Export disorders for VKORC1L1 gene to outside databases
|
Publications
for VKORC1L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VKORC1L1 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with VKORC1L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. (PubMed id 14765194)1, 2 Rost S.... Oldenburg J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- No association between vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) and the variability of warfarin dose requirement in a Japanese patient population. (PubMed id 17996924)1, 9 Yin T....Miyata T. (2008)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant fun ction. (PubMed id 21367861)1 Westhofen P....Oldenburg J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for VKORC1L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VKORC1L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VKORC1L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VKORC1L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VKORC1L1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for VKORC1L1 gene:
Search GeneIP for patents involving VKORC1L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VKORC1L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VKORC1L1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VKORC1L1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VKORC1L1 | | | OriGene Protein Over-expression Lysate for VKORC1L1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for VKORC1L1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1L1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1L1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VKORC1L1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VKORC1L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VKORC1L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VKORC1L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VKORC1L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VKORC1L1 |
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 | | | VKORC1L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VKORC1L1 |
|  |  |  | | | | Search ThermoFisher Antibodies for VKORC1L1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VKORC1L1 |
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