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Aliases for VKORC1L1 Gene

Aliases for VKORC1L1 Gene

  • Vitamin K Epoxide Reductase Complex, Subunit 1-Like 1 2 3
  • VKORC1-Like Protein 1 4
  • EC 1.17.4.4 4

External Ids for VKORC1L1 Gene

Previous GeneCards Identifiers for VKORC1L1 Gene

  • GC07P064749
  • GC07P064782
  • GC07P064975
  • GC07P065338
  • GC07P061601
  • GC07P065874

Summaries for VKORC1L1 Gene

GeneCards Summary for VKORC1L1 Gene

VKORC1L1 (Vitamin K Epoxide Reductase Complex, Subunit 1-Like 1) is a Protein Coding gene. Among its related pathways are Ubiquinol biosynthesis. GO annotations related to this gene include quinone binding and vitamin-K-epoxide reductase (warfarin-sensitive) activity. An important paralog of this gene is ENSG00000255439.

UniProtKB/Swiss-Prot for VKORC1L1 Gene

  • Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VKORC1L1 Gene

Genomics for VKORC1L1 Gene

Regulatory Elements for VKORC1L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VKORC1L1 Gene

Chromosome:
7
Start:
65,836,336 bp from pter
End:
65,959,563 bp from pter
Size:
123,228 bases
Orientation:
Plus strand

Genomic View for VKORC1L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VKORC1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VKORC1L1 Gene

Proteins for VKORC1L1 Gene

  • Protein details for VKORC1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0U8-VKORL_HUMAN
    Recommended name:
    Vitamin K epoxide reductase complex subunit 1-like protein 1
    Protein Accession:
    Q8N0U8
    Secondary Accessions:
    • B4E222
    • E7ETM5
    • Q6AHW9
    • Q6TEK6

    Protein attributes for VKORC1L1 Gene

    Size:
    176 amino acids
    Molecular mass:
    19836 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin (coumadin)

    Alternative splice isoforms for VKORC1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VKORC1L1 Gene

Proteomics data for VKORC1L1 Gene at MOPED

Post-translational modifications for VKORC1L1 Gene

  • Ubiquitination at Lys 57 and Lys 168
  • Modification sites at PhosphoSitePlus

Other Protein References for VKORC1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VKORC1L1 Gene

Domains & Families for VKORC1L1 Gene

Protein Domains for VKORC1L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for VKORC1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N0U8

UniProtKB/Swiss-Prot:

VKORL_HUMAN :
  • Belongs to the VKOR family.
Family:
  • Belongs to the VKOR family.
genes like me logo Genes that share domains with VKORC1L1: view

No data available for Gene Families for VKORC1L1 Gene

Function for VKORC1L1 Gene

Molecular function for VKORC1L1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phylloquinone + oxidized dithiothreitol + H(2)O = 2,3-epoxy-2-methyl-3- phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by warfarin (coumadin).
UniProtKB/Swiss-Prot Function:
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to oxidative stress induced by hydrogen peroxide treatment.

Enzyme Numbers (IUBMB) for VKORC1L1 Gene

Gene Ontology (GO) - Molecular Function for VKORC1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity IDA 21367861
GO:0048038 quinone binding IEA --
genes like me logo Genes that share ontologies with VKORC1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VKORC1L1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for VKORC1L1 Gene

Localization for VKORC1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VKORC1L1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VKORC1L1 Gene COMPARTMENTS Subcellular localization image for VKORC1L1 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for VKORC1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 21367861
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with VKORC1L1: view

Pathways & Interactions for VKORC1L1 Gene

genes like me logo Genes that share pathways with VKORC1L1: view

Pathways by source for VKORC1L1 Gene

1 KEGG pathway for VKORC1L1 Gene

Interacting Proteins for VKORC1L1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353998%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000378426%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000353998 for VKORC1L1 Gene via STRING

Gene Ontology (GO) - Biological Process for VKORC1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017187 peptidyl-glutamic acid carboxylation IMP 24532791
GO:0034599 cellular response to oxidative stress IMP 21367861
GO:0042373 vitamin K metabolic process IDA 21367861
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with VKORC1L1: view

No data available for SIGNOR curated interactions for VKORC1L1 Gene

Drugs & Compounds for VKORC1L1 Gene

(2) Drugs for VKORC1L1 Gene - From: DGIdb, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra inhibitor, Target, cofactor 183
Warfarin Approved Pharma inhibitor 391
genes like me logo Genes that share compounds with VKORC1L1: view

Transcripts for VKORC1L1 Gene

mRNA/cDNA for VKORC1L1 Gene

(4) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VKORC1L1 Gene

Vitamin K epoxide reductase complex, subunit 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VKORC1L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VKORC1L1 Gene

No ASD Table

Relevant External Links for VKORC1L1 Gene

GeneLoc Exon Structure for
VKORC1L1
ECgene alternative splicing isoforms for
VKORC1L1

Expression for VKORC1L1 Gene

mRNA expression in normal human tissues for VKORC1L1 Gene

Protein differential expression in normal tissues from HIPED for VKORC1L1 Gene

This gene is overexpressed in Adipocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VKORC1L1 Gene



SOURCE GeneReport for Unigene cluster for VKORC1L1 Gene Hs.427232

genes like me logo Genes that share expression patterns with VKORC1L1: view

Protein tissue co-expression partners for VKORC1L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VKORC1L1 Gene

Orthologs for VKORC1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VKORC1L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VKORC1L1 35
  • 91.86 (n)
  • 95.45 (a)
VKORC1L1 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VKORC1L1 35
  • 94.32 (n)
  • 97.73 (a)
VKORC1L1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vkorc1l1 35
  • 92.05 (n)
  • 97.16 (a)
Vkorc1l1 16
Vkorc1l1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VKORC1L1 35
  • 100 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Vkorc1l1 35
  • 92.99 (n)
  • 97.16 (a)
oppossum
(Monodelphis domestica)
Mammalia VKORC1L1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves VKORC1L1 35
  • 81.82 (n)
  • 83.52 (a)
VKORC1L1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VKORC1L1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vkorc1l1 35
  • 78.1 (n)
  • 79.43 (a)
zebrafish
(Danio rerio)
Actinopterygii vkorc1l1 35
  • 74.29 (n)
  • 71.43 (a)
vkorc1l1 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12700 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000543 35
  • 54.4 (n)
  • 40.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vkor 36
  • 26 (a)
OneToMany
Species with no ortholog for VKORC1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VKORC1L1 Gene

ENSEMBL:
Gene Tree for VKORC1L1 (if available)
TreeFam:
Gene Tree for VKORC1L1 (if available)

Paralogs for VKORC1L1 Gene

Paralogs for VKORC1L1 Gene

(1) SIMAP similar genes for VKORC1L1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for VKORC1L1 Gene

genes like me logo Genes that share paralogs with VKORC1L1: view

Variants for VKORC1L1 Gene

Sequence variations from dbSNP and Humsavar for VKORC1L1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9709 -- 65,958,300(-) GATCA(C/T)ATACC utr-variant-3-prime
rs1134233 -- 65,957,341(+) ccagg(C/T)gcagt utr-variant-3-prime
rs1134234 -- 65,957,343(+) aggcg(C/T)agtgg utr-variant-3-prime
rs1134236 -- 65,957,344(+) ggcgc(A/G)gtggc utr-variant-3-prime
rs1134237 -- 65,957,348(+) cagtg(C/G)cacac utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VKORC1L1 Gene

Variant ID Type Subtype PubMed ID
dgv2088e1 CNV Complex 17122850
esv2664145 CNV Deletion 23128226
nsv888321 CNV Gain 21882294
esv21527 CNV Gain 19812545
dgv7319n71 CNV Gain 21882294

Variation tolerance for VKORC1L1 Gene

Residual Variation Intolerance Score: 48.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.79; 83.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VKORC1L1 Gene

HapMap Linkage Disequilibrium report
VKORC1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VKORC1L1 Gene

Disorders for VKORC1L1 Gene

Relevant External Links for VKORC1L1

Genetic Association Database (GAD)
VKORC1L1
Human Genome Epidemiology (HuGE) Navigator
VKORC1L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VKORC1L1
genes like me logo Genes that share disorders with VKORC1L1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VKORC1L1 Gene

Publications for VKORC1L1 Gene

  1. VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. (PMID: 23928358) Hammed A. … Lattard V. (J. Biol. Chem. 2013) 2 67
  2. No association between vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) and the variability of warfarin dose requirement in a Japanese patient population. (PMID: 17996924) Yin T. … Miyata T. (Thromb. Res. 2008) 23 67
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  5. Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle. (PMID: 16677080) Oldenburg J. … Watzka M. (Antioxid. Redox Signal. 2006) 25 26

Products for VKORC1L1 Gene

Sources for VKORC1L1 Gene

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