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VKORC1 Gene

protein-coding   GIFtS: 63

GC16M031009
vitamin K epoxide reductase complex, subunit 1
(Previous name: vitamin K dependent clotting factors deficiency 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: VKCFD2)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 1.1.4.1 3
EDTP308 2
FLJ00289 2, 5
IMAGE3455200 2
MGC2694 2
MST134 2
MST576 2
VKCFD2 2, 5
VKOR 2, 3, 5
Descriptions
Vitamin K1 2,3-epoxide reductase subunit 1 3
phylloquinone epoxide reductase 2
vitamin K dependent clotting factors deficiency 2 1, 2
vitamin K epoxide reductase complex, subunit 1 2
vitamin K1 epoxide reductase (warfarin-sensitive) 2
External Ids
HGNC: 236631
Entrez Gene: 790012
UniProtKB: Q9BQB63
Ensembl: ENSG000001673977
Search outside databases for aliases for VKORC1 gene

Previous GC identifer: GC16M031138

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VKORC1:
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically
activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid
residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is
responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding
can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the
product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be
associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with
warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome.
Two alternatively spliced transcripts encoding different isoforms have been described. [provided
by RefSeq]

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6
Function: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase
(VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K

Gene Wiki entry for VKORC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VKORC1 gene  

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

VKORC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M031009:     (about GC identifiers)

Start:
31,009,664 bp from pter
End:
31,014,802 bp from pter
Size:
5,139 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6 (See protein sequence)
Recommended Name: Vitamin K epoxide reductase complex subunit 1  
Size: 163 amino acids; 18235 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Miscellaneous: The location of two cysteine active-site residues within a proposed transmembrane is
consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and
with the lipophilicity of vitamin K and warfarin
Secondary accessions: Q6UX90 Q7Z2R4
Alternative splicing: 2 isoforms:  Q9BQB6-1   Q9BQB6-2   

REFSEQ proteins (2 alternative transcripts): 
NP_076869.1  NP_996560.1  


ENSEMBL proteins: 
ENSP00000378426 ENSP00000326135 ENSP00000378425 ENSP00000300851 ENSP00000346969 ENSP00000378422 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (vitamin K epoxide reductase complex subunit 1)
Human Recombinant Proteins from Abnova (VKORC1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane IEA--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for VKORC1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (vitamin K epoxide reductase complex subunit 1), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for VKORC1

Assays for VKORC1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR012932 VKOR


   GeneDecks  VKORC1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9BQB6

ProtoNet protein and cluster: Q9BQB6

1 Blocks protein family: IPB012932 Vitamin K epoxide reductase

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6
Similarity: Belongs to the VKOR family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (VKORC1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_206824

              Applied Biosystems Silencer® siRNAs for VKORC1

              Sigma-Aldrich siRNA for VKORC1  
                     Sigma-Aldrich shRNA for VKORC1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for VKORC1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_024006
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_024006
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024006 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_024006

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6
Function: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase
(VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K
Catalytic activity: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol =
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
Enzyme Number (IUBMB): EC 1.1.4.1 

1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Vkorc1):

homeostasis/metabolism

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016491 oxidoreductase activity IEA--
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  VKORC1  (Your Favorite Gene powered by Ingenuity) 
 Biosynthesis of Steroids

   GeneDecks  VKORC1 for the pathways selected above  
About GeneDecksing

1 Kegg Pathway  (Kegg details for VKORC1):
 hsa00100 Biosynthesis of steroids

   GeneDecks  VKORC1 for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  VKORC1 


5/13 Interacting proteins for VKORC1 (ENSP000003008513) via UniProtKB, MINT, and/or STRING (see all 13 )
InteractantInteraction Details
GeneCardExternal ID(s)
GGCXENSP000002338383STRING (score=.996)
NQO1ENSP000003197883STRING (score=.954)
CYP2C9ENSP000002606823STRING (score=.931)
EPHX1ENSP000003558023STRING (score=.908)
PROCENSP000002340713STRING (score=.825)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0055114 oxidation reduction IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VKORC1
6 Novoseek chemical compound relationships for VKORC1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin k epoxide 99.26 173 2342073 (4), 16270630 (4), 19181737 (2), 14765194 (2) (see all 91)
vitamin k hydroquinone 93.98 6 16081695 (1), 16270630 (1), 9360981 (1), 17070618 (1) (see all 6)
r-warfarin 65.06 1 16879214 (1)
epoxide 60.23 6 15972850 (1), 16270630 (1), 16493479 (1), 18266023 (1) (see all 6)
gamma-carboxyglutamic acid 47.97 2 15640149 (2)
dithiothreitol 12.73 1 16634640 (1)
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1 PharmGKB drug compound relationship for VKORC1 gene
Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
warfarinCO  PD  14765194
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (VKORC1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_206824

              Sigma-Aldrich siRNA for VKORC1  
                     Sigma-Aldrich shRNA for VKORC1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_024006  NM_206824  

REFSEQ mRNAs for VKORC1 gene (2 alternative transcripts): 

NM_024006.4   NM_206824.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_024006  NM_206824  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_024006
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_024006
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024006 

Additional cDNA sequence: 

AF176924.1 AK129513.1 AK289790.1 AK312005.1 AY423044.1 AY466113.1 AY521634.1 BC000828.1 
BC002911.2 CR623242.1 

9 DOTS entries:

DT.100661283  DT.101972440  DT.97869834  DT.100661277  DT.95285781  DT.100661278  DT.91759743  DT.444354 
DT.100661280 

24/429 AceView cDNA sequences (see all 429 ):

AW204374 AI869318 AW404352 AA553820 BQ689511 F30350 AI869708 BM313349 
BM046051 BU726291 BG034488 BU626701 BQ924237 CA423003 BM697994 BQ054509 
AW872762 AI220792 AI379942 CA950830 CA777346 BC002911 BQ637491 BM699427 

highest scoring ESTs for VKORC1:

AA041425 AA041429 AA045652 AA125766 AA146970 AA205661 AA297475 AA297517 AA298624 AA478165 

Unigene Cluster for VKORC1:

Vitamin K epoxide reductase complex, subunit 1
Hs.324844  [show with all ESTs]
Unigene Representative Sequence: CD251196


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for VKORC1

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d
SP1:                          -     -                                       
SP2:                          -     -           -                           
SP3:                          -                 -                           
SP4:                          -     -     -     -                           
SP5:                                            -                           

About this scheme

ECgene alternative splicing isoforms for VKORC1

6 Ensembl transcripts including schematic representations:
ENST00000394975  ENST00000319788  ENST00000394974  ENST00000300851  ENST00000354895  ENST00000394971  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VKORC1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for VKORC1

1 / 2 / 3

3 probe-sets matching VKORC1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

45283_at2, 3 U95-B 3 1.00 0.94 1.00 1.00 AA146970 0.80 1.00 0.91 1

217949_s_at2, 3 U133-A 2 1.00 0.95 -- -- NM_024006 0.60 1.00 0.82 1

217949_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGCTGGTCTC

SOURCE GeneReport for Unigene cluster: Hs.324844

Expression variation in blood from EXPOLDB for VKORC1

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6
Tissue specificity: Expressed at highest levels in fetal and adult liver, followed by fetal heart,
kidney, and lung, adult heart, and pancreas

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for VKORC1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
VKORC11   -- vitamin K epoxide reductase complex, subunit 1 87.93(n)
90.8(a)
479775  XM_536902.2  XP_536902.1 
cow
(Bos taurus)
VKORC11   -- vitamin K epoxide reductase complex, subunit 1 87.73(n)
90.18(a)
445422  NM_001003903.1  NP_001003903.1 
rat
(Rattus norvegicus)
Vkorc11   -- vitamin K epoxide reductase complex, subunit 1 83.96(n)
84.37(a)
309004  NM_203335.2  NP_976080.1 
mouse
(Mus musculus)
Vkorc11, 5 7 (61.00 cM)5
vitamin K epoxide reductase complex, subunit 11, 5 83.02(n)1
85.71(a)1
279731  NM_178600.21  NP_848715.11 
 AA4101395  AI4145445  (see all 14)
zebrafish
(Danio rerio)
wu:fc03a111   -- wu:fc03a11 56.04(n)
53.75(a)
100000559  XM_001336424.1  XP_001336460.1 
About this table        Species with no ortholog for VKORC1

ENSEMBL Gene Tree for VKORC1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for VKORC1 gene
VKORC1L12  

Pseudogenes
1 related pseudogene


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/42 NCBI SNPs in VKORC1 are shown (see all 42 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 42)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 16 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs72941,2
A,C,F,H,O31009822(-) TACCCG/ACACAT 2 -- ut3111Minor allele frequency- A:0.36MN NA NS EU EA WA 1508
rs72007491,2
A,C,F,H31010090(+) GGCCAG/AGTAGA 2 L/P L/L mis1 syn123Minor allele frequency- A:0.06NA NS EU EA WA 2142
rs99232311,2
A,C,F31015190(+) gcaccC/TggccA 2 -- ng312Minor allele frequency- T:0.28NS 84
rs178785441,2
F31015428(-) AACCTA/GTCATA 2 -- ng31 tfbs32Minor allele frequency- G:0.14NS 90
--
rs178782591,2
F31014144(-) CAGAGT/CCTCAC 2 -- ng312Minor allele frequency- C:0.02NS 86
rs10460301,2
A31009704(-) AGGTTC/TTGAGC 2 -- ut310--------
rs80508941,2
A,C,F,H31012010(+) CGCTCC/GGTGAT 2 -- int121Minor allele frequency- G:0.45EU EA WA NS NA 2598
rs23596121,2
A,C,F,H31011297(+) GGACCG/ATGGTG 2 -- int112Minor allele frequency- A:0.48EU EA WA NS 1104
--
rs133363841,2
C,F,H31012672(+) ttaagG/Acaccc 2 -- int16Minor allele frequency- A:0.01EU EA WA NS 492
rs28847371,2
A,C,F31013055(+) CCTTCA/CCCTGC 2 -- int13Minor allele frequency- C:0.24NS 774
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HapMap Linkage Disequilibrium images for VKORC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608547   disorders: 607473  122700  

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6

  • Defects in VKORC1 are a cause of combined eficiency of all vitamin K-dependent clotting
    factors type 2 (VKCFD2) [MIM:607473]. VKCFD leads to a bleeding tendency that is usually reversed
    by oral administration of vitamin K
  • Defects in VKORC1 are a cause of coumarin resistance [MIM:122700]; also known as warfarin
    resistance. Warfarin and other coumarin-type anticoagulants are used to reduce blood viscosity in
    the treatment of thromboembolic disorders
  • 8 Novoseek disease relationships for VKORC1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    warfarin resistance 94.03 18 14765194 (2), 18680536 (2), 15630486 (2), 18266023 (2) (see all 9)
    coagulation factor deficiency 78.78 5 16720838 (1), 14765194 (1), 16270630 (1), 19116367 (1)
    bleeding 44.58 6 16201835 (3), 18374188 (1), 17717937 (1), 18322281 (1) (see all 5)
    aortic dissection 16.52 5 16549638 (3), 17549303 (1)
    tumors 1.00 1 15972850 (1)
    stroke 0.88 12 18841283 (6), 16549638 (3), 17049586 (1), 17549303 (1)
    atherosclerosis 0.00 2 16549638 (1)
    coronary heart disease 0.00 7 16549638 (3), 17549303 (2), 18841283 (1)
    About this table

    1 PharmGKB disease relationship for VKORC1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Coagulation Protein DisordersCO  PD  14765194
    About this table

    Human Gene Mutation Database: VKORC1
    Genetic Association Database: VKORC1
    Human Genome Epidemiology Navigator: VKORC1 (109 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/183 PubMed articles for VKORC1 gene (see all 183 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 79001 HGNC: 23663 AceView: VKORC1 Ensembl:ENSG00000167397 euGenes: HUgn79001
    ECgene: VKORC1 H-InvDB: VKORC1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    SeattleSNPshttp://pga.gs.washington.edu/data/vkorc1/
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for VKORC1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VKORC1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for VKORC1 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for VKORC1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
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     Antibodies (vitamin K epoxide reductase complex subunit 1)
     Search OriGene for VKORC1
     Search Tocris compounds for VKORC1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for VKORC1

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