V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

VKORC1 Gene

protein-coding GIFtS: 63

GC16M031009

vitamin K epoxide reductase complex, subunit 1
(Previous name: vitamin K dependent clotting factors deficiency 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: VKCFD2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.1.4.1 ^³
EDTP308 ^²
FLJ00289 ^², ⁵
IMAGE3455200 ^²
MGC2694 ^²
MST134 ^²
MST576 ^²
VKCFD2 ^², ⁵
VKOR ^², ³, ⁵

Descriptions
Vitamin K1 2,3-epoxide reductase subunit 1 ^³
phylloquinone epoxide reductase ^²
vitamin K dependent clotting factors deficiency 2 ^¹, ²
vitamin K epoxide reductase complex, subunit 1 ^²
vitamin K1 epoxide reductase (warfarin-sensitive) ^²

External Ids
HGNC: 23663¹
Entrez Gene: 79001²
UniProtKB: Q9BQB6³
Ensembl: ENSG00000167397⁷

Search outside databases for aliases for VKORC1 gene

Previous GC identifer: GC16M031138

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VKORC1:

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically

activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid

residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is

responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding

can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the

product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be

associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with

warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome.

Two alternatively spliced transcripts encoding different isoforms have been described. [provided

by RefSeq]

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6

Function: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase

(VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K

Gene Wiki entry for VKORC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the VKORC1 gene

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

VKORC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M031009: (about GC identifiers)

Start:	31,009,664 bp from pter
End:	31,014,802 bp from pter
Size:	5,139 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6 (See protein sequence)

Recommended Name: Vitamin K epoxide reductase complex subunit 1

Size: 163 amino acids; 18235 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Miscellaneous: The location of two cysteine active-site residues within a proposed transmembrane is

consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and

with the lipophilicity of vitamin K and warfarin

Secondary accessions: Q6UX90 Q7Z2R4

Alternative splicing: 2 isoforms: Q9BQB6-1 Q9BQB6-2

REFSEQ proteins (2 alternative transcripts):

NP_076869.1 NP_996560.1

ENSEMBL proteins:

ENSP00000378426 ENSP00000326135 ENSP00000378425 ENSP00000300851 ENSP00000346969 ENSP00000378422

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (vitamin K epoxide reductase complex subunit 1)
	Human Recombinant Proteins from Abnova (VKORC1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for VKORC1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (vitamin K epoxide reductase complex subunit 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for VKORC1

Assays for VKORC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BQB6

ProtoNet protein and cluster: Q9BQB6

1 Blocks protein family: IPB012932 Vitamin K epoxide reductase

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6

Similarity: Belongs to the VKOR family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VKORC1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_206824

Applied Biosystems Silencer® siRNAs for VKORC1

Sigma-Aldrich siRNA for VKORC1

Sigma-Aldrich shRNA for VKORC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for VKORC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_024006
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_024006
untagged cDNA clones in CMV expression vector (see all 2): NM_024006

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024006

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6

Function: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase

(VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K

Catalytic activity: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol =

2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

Enzyme Number (IUBMB): EC 1.1.4.1

1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Vkorc1):

homeostasis/metabolism

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016491	oxidoreductase activity	IEA	--
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for VKORC1 (Your Favorite Gene powered by Ingenuity)

Biosynthesis of Steroids

GeneDecks VKORC1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for VKORC1

5/13 Interacting proteins for VKORC1 (ENSP00000300851³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GGCX	ENSP00000233838³	STRING (score=.996)
NQO1	ENSP00000319788³	STRING (score=.954)
CYP2C9	ENSP00000260682³	STRING (score=.931)
EPHX1	ENSP00000355802³	STRING (score=.908)
PROC	ENSP00000234071³	STRING (score=.825)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VKORC1
6 Novoseek chemical compound relationships for VKORC1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin k epoxide	99.26	173	2342073 (4), 16270630 (4), 19181737 (2), 14765194 (2) (see all 91)
vitamin k hydroquinone	93.98	6	16081695 (1), 16270630 (1), 9360981 (1), 17070618 (1) (see all 6)
r-warfarin	65.06	1	16879214 (1)
epoxide	60.23	6	15972850 (1), 16270630 (1), 16493479 (1), 18266023 (1) (see all 6)
gamma-carboxyglutamic acid	47.97	2	15640149 (2)
dithiothreitol	12.73	1	16634640 (1)

About this table

1 PharmGKB drug compound relationship for VKORC1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
warfarin	CO PD	14765194

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (VKORC1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_206824

Sigma-Aldrich siRNA for VKORC1

Sigma-Aldrich shRNA for VKORC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024006 NM_206824

REFSEQ mRNAs for VKORC1 gene (2 alternative transcripts):

NM_024006.4 NM_206824.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024006 NM_206824

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_024006
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_024006
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024006

Additional cDNA sequence:

AF176924.1 AK129513.1 AK289790.1 AK312005.1 AY423044.1 AY466113.1 AY521634.1 BC000828.1

BC002911.2 CR623242.1

9 DOTS entries:

DT.100661283 DT.101972440 DT.97869834 DT.100661277 DT.95285781 DT.100661278 DT.91759743 DT.444354

DT.100661280

24/429 AceView cDNA sequences (see all 429 ):

AW204374 AI869318 AW404352 AA553820 BQ689511 F30350 AI869708 BM313349

BM046051 BU726291 BG034488 BU626701 BQ924237 CA423003 BM697994 BQ054509

AW872762 AI220792 AI379942 CA950830 CA777346 BC002911 BQ637491 BM699427

highest scoring ESTs for VKORC1:

AA041425 AA041429 AA045652 AA125766 AA146970 AA205661 AA297475 AA297517 AA298624 AA478165

Unigene Cluster for VKORC1:

Vitamin K epoxide reductase complex, subunit 1

Hs.324844 [show with all ESTs]

Unigene Representative Sequence: CD251196

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for VKORC1

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	·	4d
SP1:									-		-
SP2:									-		-				-
SP3:									-						-
SP4:									-		-		-		-
SP5:															-

About this scheme

ECgene alternative splicing isoforms for VKORC1

6 Ensembl transcripts including schematic representations:

ENST00000394975 ENST00000319788 ENST00000394974 ENST00000300851 ENST00000354895 ENST00000394971

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VKORC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for VKORC1

¹ / ² / ³

3 probe-sets matching VKORC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45283_at²^{, 3}	U95-B	3	1.00	0.94	1.00	1.00	AA146970	0.80	1.00	0.91	1
217949_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_024006	0.60	1.00	0.82	1
217949_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCTGGTCTC

SOURCE GeneReport for Unigene cluster: Hs.324844
Expression variation in blood from EXPOLDB for VKORC1
UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6
Tissue specificity: Expressed at highest levels in fetal and adult liver, followed by fetal heart,
kidney, and lung, adult heart, and pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VKORC1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VKORC1¹	--	vitamin K epoxide reductase complex, subunit 1	87.93(n) 90.8(a)	479775 XM_536902.2 XP_536902.1
cow (Bos taurus)	VKORC1¹	--	vitamin K epoxide reductase complex, subunit 1	87.73(n) 90.18(a)	445422 NM_001003903.1 NP_001003903.1
rat (Rattus norvegicus)	Vkorc1¹	--	vitamin K epoxide reductase complex, subunit 1	83.96(n) 84.37(a)	309004 NM_203335.2 NP_976080.1
mouse (Mus musculus)	Vkorc1^{1, 5}	7 (61.00 cM)⁵	vitamin K epoxide reductase complex, subunit 1^{1, 5}	83.02(n)¹ 85.71(a)¹	27973¹ NM_178600.2¹ NP_848715.1¹ AA410139⁵ AI414544⁵ (see all 14)
zebrafish (Danio rerio)	wu:fc03a11¹	--	wu:fc03a11	56.04(n) 53.75(a)	100000559 XM_001336424.1 XP_001336460.1

About this table Species with no ortholog for VKORC1

ENSEMBL Gene Tree for VKORC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VKORC1 gene

VKORC1L1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/42 NCBI SNPs in VKORC1 are shown (see all 42 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7294^1,2	A,C,F,H,O	31009822(-)	`TACCCG/ACACAT`	2	--	ut3¹		11		MN NA NS EU EA WA	1508
	rs7200749^1,2	A,C,F,H	31010090(+)	`GGCCAG/AGTAGA`	2	L/P L/L	mis¹ syn¹		23		NA NS EU EA WA	2142
	rs9923231^1,2	A,C,F	31015190(+)	`gcaccC/TggccA`	2	--	ng3¹		2		NS	84
	rs17878544^1,2	F	31015428(-)	`AACCTA/GTCATA`	2	--	ng3¹ tfbs³		2		NS	90
--	rs17878259^1,2	F	31014144(-)	`CAGAGT/CCTCAC`	2	--	ng3¹		2		NS	86
	rs1046030^1,2	A	31009704(-)	`AGGTTC/TTGAGC`	2	--	ut3¹		0	--	--	--	--
	rs8050894^1,2	A,C,F,H	31012010(+)	`CGCTCC/GGTGAT`	2	--	int¹		21		EU EA WA NS NA	2598
	rs2359612^1,2	A,C,F,H	31011297(+)	`GGACCG/ATGGTG`	2	--	int¹		12		EU EA WA NS	1104
--	rs13336384^1,2	C,F,H	31012672(+)	`ttaagG/Acaccc`	2	--	int¹		6		EU EA WA NS	492
	rs2884737^1,2	A,C,F	31013055(+)	`CCTTCA/CCCTGC`	2	--	int¹		3		NS	774

About this table

HapMap Linkage Disequilibrium images for VKORC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608547 disorders: 607473 122700

UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6

Defects in VKORC1 are a cause of combined eficiency of all vitamin K-dependent clotting

factors type 2 (VKCFD2) [MIM:607473]. VKCFD leads to a bleeding tendency that is usually reversed

by oral administration of vitamin K

Defects in VKORC1 are a cause of coumarin resistance [MIM:122700]; also known as warfarin

resistance. Warfarin and other coumarin-type anticoagulants are used to reduce blood viscosity in

the treatment of thromboembolic disorders

8 Novoseek disease relationships for VKORC1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
warfarin resistance	94.03	18	14765194 (2), 18680536 (2), 15630486 (2), 18266023 (2) (see all 9)
coagulation factor deficiency	78.78	5	16720838 (1), 14765194 (1), 16270630 (1), 19116367 (1)
bleeding	44.58	6	16201835 (3), 18374188 (1), 17717937 (1), 18322281 (1) (see all 5)
aortic dissection	16.52	5	16549638 (3), 17549303 (1)
tumors	1.00	1	15972850 (1)
stroke	0.88	12	18841283 (6), 16549638 (3), 17049586 (1), 17549303 (1)
atherosclerosis	0.00	2	16549638 (1)
coronary heart disease	0.00	7	16549638 (3), 17549303 (2), 18841283 (1)

About this table

1 PharmGKB disease relationship for VKORC1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Coagulation Protein Disorders	CO PD	14765194

About this table

Human Gene Mutation Database: VKORC1
Genetic Association Database: VKORC1
Human Genome Epidemiology Navigator: VKORC1 (109 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/183 PubMed articles for VKORC1 gene (see all 183 ):

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. (PubMed id 14765194)^{1, 3, 4, 7} Rost S.... Oldenburg J. (2004)
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. (PubMed id 15930419)^{1, 3, 6} Rieder M.J....Rettie A.E. (2005)
Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. (PubMed id 16270630)^{1, 3, 4} Rost S....Oldenburg J. (2005)
Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population. (PubMed id 16141794)^{1, 3, 6} Veenstra D.L....Rettie A.E. (2005)
Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. (PubMed id 15716279)^{1, 3, 4} Tie J.-K.... Stafford D.W. (2005)
VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation. (PubMed id 16270629)^{1, 3, 6} Geisen C....Oldenburg J. (2005)
Identification of the gene for vitamin K epoxide reductase. (PubMed id 14765195)^{1, 3, 4} Li T.... Stafford D.W. (2004)
A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin. (PubMed id 15358623)^{1, 3, 6} D'Andrea G....Margaglione M. (2005)
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. (PubMed id 15790782)^{1, 3, 6} Bodin L....Loriot M.A. (2005)
A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk. (PubMed id 16201835)^{1, 3, 6} Reitsma P.H....Buller H.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79001	HGNC: 23663	AceView: VKORC1	Ensembl:ENSG00000167397	euGenes: HUgn79001
ECgene: VKORC1	H-InvDB: VKORC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/vkorc1/

Licensable Technologies for VKORC1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for VKORC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for VKORC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for VKORC1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for VKORC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (VKORC1)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (vitamin K epoxide reductase complex subunit 1)
	Antibodies (vitamin K epoxide reductase complex subunit 1)

Search OriGene for VKORC1

Search Tocris compounds for VKORC1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for VKORC1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
VKORC1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

VKORC1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for VKORC1

Summaries
for VKORC1

Genomic Location
for VKORC1

Proteins
for VKORC1

Protein Domains/
Families
for VKORC1

Gene Function
for VKORC1

Pathways & Interactions
for VKORC1

Drugs & Compounds
for VKORC1

Transcripts
for VKORC1

Expression
for VKORC1

Orthologs
for VKORC1

Paralogs
for VKORC1

SNPs/Variants
for VKORC1

Disorders & Mutations
for VKORC1

Medical News
for VKORC1

Publications
for VKORC1

Search for VKORC1

Genome Databases showing VKORC1

Other Databases showing VKORC1

Specialized Databases showing VKORC1

Licensable Technologies
for VKORC1

Services
for VKORC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

VKORC1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor VKORC1

Summariesfor VKORC1

Genomic Locationfor VKORC1

Proteinsfor VKORC1

Protein Domains/Familiesfor VKORC1

Gene Functionfor VKORC1

Pathways & Interactionsfor VKORC1

Drugs & Compoundsfor VKORC1

Transcriptsfor VKORC1

Expression for VKORC1

Orthologsfor VKORC1

Paralogsfor VKORC1

SNPs/Variantsfor VKORC1

Disorders & Mutationsfor VKORC1

Medical Newsfor VKORC1

Publicationsfor VKORC1

Search for VKORC1

Genome Databases showing VKORC1

Other Databases showing VKORC1

Specialized Databases showing VKORC1

Licensable Technologiesfor VKORC1

Servicesfor VKORC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for VKORC1

Summaries
for VKORC1

Genomic Location
for VKORC1

Proteins
for VKORC1

Protein Domains/
Families
for VKORC1

Gene Function
for VKORC1

Pathways & Interactions
for VKORC1

Drugs & Compounds
for VKORC1

Transcripts
for VKORC1

Expression
for VKORC1

Orthologs
for VKORC1

Paralogs
for VKORC1

SNPs/Variants
for VKORC1

Disorders & Mutations
for VKORC1

Medical News
for VKORC1

Publications
for VKORC1

Licensable Technologies
for VKORC1

Services
for VKORC1