VKORC1 Gene
protein-coding GIFtS: 60
GCID: GC16M031105
|
|
vitamin K epoxide reductase complex, subunit 1(Previous name: vitamin K dependent clotting factors deficiency 2 )
(Previous symbol: VKCFD2)
| |
Aliases
for VKORC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vitamin K Epoxide Reductase Complex, Subunit 11 2 | | IMAGE34552002 | | VKCFD21 2 5 | | MST1342 | | VKOR2 3 5 | | MST5762 | | Vitamin K Dependent Clotting Factors Deficiency 21 2 | | Phylloquinone Epoxide Reductase2 | | Vitamin K1 2,3-Epoxide Reductase Subunit 12 3 | | Vitamin K Epoxide Reductase Complex Subunit 12 | | EC 1.1.4.13 8 | | Vitamin K1 Epoxide Reductase (Warfarin-Sensitive)2 | | EDTP3082 | | FLJ002895 |
Export aliases for VKORC1 gene to outside databasesPrevious GC identifers: GC16M031138 GC16M031009 GC16M028663 |
Summaries
for VKORC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VKORC1:
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form ofvitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins.The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to theenzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonistwarfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can beassociated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarinresistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively splicedtranscripts encoding different isoforms have been described. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6Function: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex whichreduces inactive vitamin K 2,3-epoxide to active vitamin K
Gene Wiki entry for VKORC1
PharmGKB "VIP" summary for
VKORC1
|
Genomic Views
for VKORC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VKORC1 gene promoter:
SRF Pax-5 SRF (504 AA) Brachyury E47 POU2F1 COMP1 POU2F1a SEF-1 (1) Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for VKORC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VKORC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2VKORC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M031105: view genomic region
(about GC identifiers)
Start:
|
31,102,163 bp from pter |
End:
|
31,107,301 bp from pter |
Size:
|
5,139 bases |
Orientation:
|
minus strand |
|
Proteins
for VKORC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6 (See
protein sequence)Recommended Name: Vitamin K epoxide reductase complex subunit 1 Size: 163 amino acids; 18235 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Miscellaneous: The location of two cysteine active-site residues within a proposed transmembrane is consistent bothwith the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin Kand warfarin
Sequence caution: Sequence=AAQ88821.1; Type=Erroneous initiation;
Secondary accessions: A6NIQ6 B2R4Z6 Q6UX90 Q7Z2R4Alternative splicing: 3 isoforms: Q9BQB6-1 Q9BQB6-2 Q9BQB6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for VKORC1: NX_Q9BQB6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BQB6
3 DME Specific Peptides for VKORC1 (Q9BQB6)
VKORC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_076869.1 NP_996560.1
ENSEMBL proteins: ENSP00000300851 ENSP00000326135 ENSP00000346969 ENSP00000378426 ENSP00000437064 ENSP00000378422 ENSP00000417662 ENSP00000458994 Reactome Protein details: Q9BQB6
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
VKORC1 for ontologies About GeneDecksing
VKORC1 Antibody Products:
Assay Products for VKORC1: |
Protein
Domains /
Families
for VKORC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VKORC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BQB6ProtoNet protein and cluster: Q9BQB6 1 Blocks protein family: IPB012932 Vitamin K epoxide reductase
UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6Similarity: Belongs to the VKOR family |
Function
for VKORC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6Function: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex whichreduces inactive vitamin K 2,3-epoxide to active vitamin KCatalytic activity: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol =2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitolEnzyme Number (IUBMB): EC 1.1.4.11 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for VKORC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VKORC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VKORC1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0047057 | vitamin-K-epoxide reductase (warfarin-sensitive) activity |
IEA | -- |
VKORC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for VKORC1:
Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Vkorc1):
VKORC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for VKORC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | | | 2 | Asparagine N-linked glycosylation | | | 3 | vitamin K epoxide -> vitamin K hydroquinone | | | 4 | PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for VKORC1
1  PharmGKB Pathway for VKORC1
VKORC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VKORC1
1 Interacting protein for VKORC1 (Q9BQB63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0017144 | drug metabolic process |
IMP | -- | | GO:0017187 | peptidyl-glutamic acid carboxylation |
TAS | -- | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
VKORC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for VKORC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
VKORC1 for compounds About GeneDecksing
 Browse Tocris compounds for VKORC1
8 HMDB Compounds for VKORC1 About this table
6 DrugBank Compounds for VKORC1 About this table
10/14 Novoseek chemical compound relationships for VKORC1 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| vitamin k epoxide |
99.3 |
229 |
2342073 (4), 16270630 (4), 19181737 (2), 17182266 (2) (see all 99) |
| vitamin k hydroquinone |
93.3 |
7 |
16081695 (1), 20110994 (1), 16270630 (1), 9360981 (1) (see all 7) |
| warfarin |
92.4 |
373 |
18680536 (8), 16513444 (6), 16890578 (6), 19077919 (5) (see all 99) |
| acenocoumarol |
87.5 |
28 |
16869821 (3), 16611310 (3), 20020283 (3), 19225451 (3) (see all 11) |
| coumarin |
78.4 |
39 |
16270630 (4), 17849045 (3), 17124101 (2), 18278162 (2) (see all 11) |
| coumarins |
77.4 |
15 |
17635701 (2), 20205664 (1), 19324988 (1), 18278162 (1) (see all 12) |
| phenprocoumon |
76.3 |
10 |
19319511 (3), 20020283 (3), 17955831 (1), 20376629 (1) (see all 6) |
| vitamin k1 |
72 |
3 |
19297519 (1) |
| epoxide |
60.2 |
8 |
15972850 (1), 18998206 (1), 19297519 (1), 16270630 (1) (see all 8) |
| r-warfarin |
59.8 |
1 |
16879214 (1) |
3 PharmGKB related drug/compound annotations for VKORC1 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about VKORC1 / VKOR1
|
Transcripts
for VKORC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VKORC1 gene (2 alternative transcripts): NM_024006.4 NM_206824.1 Unigene Cluster for VKORC1: Vitamin K epoxide reductase complex, subunit 1 Hs.324844 [show with all ESTs]Unigene Representative Sequence: CD2511968 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000300851 ENST00000319788(uc002eau.3) ENST00000354895(uc002eat.3)
ENST00000394975(uc002eas.3) ENST00000420057 ENST00000394971 ENST00000498155
ENST00000472468
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): VKORC1 (NM_024006) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VKORC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VKORC1 |
Additional cDNA sequence: AF176924.1 AK129513.1 AK289790.1 AK312005.1 AY423044.1 AY466113.1 AY521634.1 BC000828.1 BC002911.2 9 DOTS entries: DT.100661283 DT.101972440 DT.97869834 DT.100661277 DT.95285781 DT.100661278 DT.91759743 DT.444354 DT.100661280 24/429 AceView cDNA sequences (see all 429): AI869708 BM311539 CN484751 BM312138 AY521634 AW026472 CA866013 BM697994 BM852721 BQ062209 BM313349 BU526891 AI915437 BX644781 BU541676 BM544275 CB126161 CA841177 CR618714 BM557143 BQ437135 AW136724 AA708126 CA423003
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for VKORC1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for VKORC1
|
Expression
for VKORC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VKORC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGGTCTC
About this image
See VKORC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VKORC1
SOURCE GeneReport for Unigene cluster: Hs.324844
UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6Tissue specificity: Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung,adult heart, and pancreas
SABiosciences Custom PCR Arrays for VKORC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VKORC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VKORC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VKORC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VKORC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VKORC1 |
Orthologs
for VKORC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for VKORC1 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for VKORC1 (if available)
TreeFam Gene Tree for VKORC1 (if available) |
Paralogs
for VKORC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VKORC1 gene
- ENSG000002554392 VKORC1L12
1 SIMAP similar gene for VKORC1 using alignment to 9 protein entries: VKOR1_HUMAN (see all proteins):VKORC1L1
VKORC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for VKORC1
PGOHUM00000241688
|
Genomic Variants
for VKORC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VKORC1 (31102163 - 31107301 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VKORC1: --
Human Gene Mutation Database (HGMD): VKORC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VKORC1 |
|
Disorders
/ Diseases
for VKORC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VKORC1 for disorders About GeneDecksing
OMIM gene information: 608547
OMIM disorders: 607473 122700
UniProtKB/Swiss-Prot: VKOR1_HUMAN, Q9BQB6
Defects in VKORC1 are a cause of combined deficiency of vitamin K-dependent clotting factors type 2 (VKCFD2)[MIM:607473]. VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K Defects in VKORC1 are a cause of coumarin resistance (CMRES) [MIM:122700]. A condition characterized bypartial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used asanti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrialfibrillation, or mechanical heart valve replacement
20/32  diseases for VKORC1 (see all 32): About MalaCardsvitamin k-dependent clotting factors vitamin k-dependent clotting factors, combined deficiency of, 2 warfarin resistance warfarin sensitivity
vitamin k deficiency hemorrhagic disease blood clots deep vein thrombosis portal vein thrombosis
coumarin resistance coronary heart disease cerebrovascular accident pulmonary embolism
hemorrhagic disease thrombosis antiphospholipid syndrome bleeding disorder
myocardial infarction vascular disease kidney disease atherosclerosis
1 disease from the University of Copenhagen DISEASES database for VKORC1:Vitamin K deficiency hemorrhagic disease 8 Novoseek disease relationships for VKORC1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| warfarin resistance |
92.6 |
18 |
14765194 (2), 18680536 (2), 15630486 (2), 18266023 (2) (see all 9) |
| coagulation factor deficiency |
78.6 |
5 |
16720838 (1), 14765194 (1), 16270630 (1), 19116367 (1) |
| bleeding |
53.3 |
16 |
16201835 (3), 20362363 (3), 20121287 (2), 20205664 (1) (see all 11) |
| stroke |
16.7 |
15 |
18841283 (6), 16549638 (3), 20193673 (2), 17049586 (1) (see all 6) |
| aortic dissection |
9.05 |
5 |
16549638 (3), 17549303 (1) |
| tumors |
0.54 |
1 |
15972850 (1) |
| atherosclerosis |
0 |
2 |
16549638 (1) |
| coronary heart disease |
0 |
7 |
16549638 (3), 17549303 (2), 18841283 (1) |
Genetic Association Database (GAD): VKORC1
Human Genome Epidemiology (HuGE) Navigator: VKORC1 (212 documents)
Export disorders for VKORC1 gene to outside databases
|
Publications
for VKORC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VKORC1 gene, integrated from 9 sources (see all 339):
(articles sorted by number of sources associating them with VKORC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. (PubMed id 15790782)1, 4, 7, 9 Bodin L....Loriot M.A. (2005)
- A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk. (PubMed id 16201835)1, 4, 7, 9 Reitsma P.H....Buller H.R. (2005)
- Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle. (PubMed id 16677080)1, 7, 9 Oldenburg J....Watzka M. (2006)
- Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. (PubMed id 16270630)1, 2, 9 Rost S....Oldenburg J. (2005)
- Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. (PubMed id 15930419)1, 4, 9 Rieder M.J....Rettie A.E. (2005)
- Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. (PubMed id 14765194)1, 2, 9 Rost S.... Oldenburg J. (2004)
- Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population. (PubMed id 16141794)1, 4, 9 Veenstra D.L....Rettie A.E. (2005)
- Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. (PubMed id 15716279)1, 2, 9 Tie J.-K.... Stafford D.W. (2005)
- VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation. (PubMed id 16270629)1, 4, 9 Geisen C....Oldenburg J. (2005)
- Identification of the gene for vitamin K epoxide reductase. (PubMed id 14765195)1, 2, 9 Li T.... Stafford D.W. (2004)
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External Searches for VKORC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing VKORC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing VKORC1 gene
(According to HUGE)
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Specialized Databases showing VKORC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for VKORC1 | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/vkorc1/ |
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| Patent Information for VKORC1 gene:
Search GeneIP for patents involving VKORC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for VKORC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VKORC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VKORC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VKORC1 | | | OriGene Protein Over-expression Lysate for VKORC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VKORC1 | | OriGene 3'-UTR Clone for VKORC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VKORC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for VKORC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VKORC1 | | OriGene Custom Protein Services for VKORC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VKORC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VKORC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VKORC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VKORC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VKORC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VKORC1 |
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| | | | Search Tocris compounds for VKORC1 |
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 | | | VKORC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VKORC1 |
|  |  |  | | | | ThermoFisher Antibodies for VKORC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VKORC1 |
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