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Aliases for VIT Gene

Aliases for VIT Gene

  • Vitrin 2 3
  • DDVIT1 6
  • UBE2V2 6
  • EDPF1 6
  • MMS2 6
  • UEV2 6

External Ids for VIT Gene

Summaries for VIT Gene

GeneCards Summary for VIT Gene

VIT (Vitrin) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include glycosaminoglycan binding. An important paralog of this gene is MATN1.

UniProtKB/Swiss-Prot for VIT Gene

  • Promotes matrix assembly and cell adhesiveness.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIT Gene

Genomics for VIT Gene

Genomic Location for VIT Gene

Start:
36,696,690 bp from pter
End:
36,814,794 bp from pter
Size:
118,105 bases
Orientation:
Plus strand

Genomic View for VIT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VIT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIT Gene

Regulatory Elements for VIT Gene

Proteins for VIT Gene

  • Protein details for VIT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXI7-VITRN_HUMAN
    Recommended name:
    Vitrin
    Protein Accession:
    Q6UXI7
    Secondary Accessions:
    • A1A526
    • A6NKI9
    • A8K7Y4
    • E9PF47
    • Q6P7T3
    • Q96DM8
    • Q96DT1
    • Q9UDN0

    Protein attributes for VIT Gene

    Size:
    678 amino acids
    Molecular mass:
    73930 Da
    Quaternary structure:
    • Binds dermatan sulfate and chondroitin sulfate.

    Alternative splice isoforms for VIT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VIT Gene

Proteomics data for VIT Gene at MOPED

Post-translational modifications for VIT Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn390 and Asn520

No data available for DME Specific Peptides for VIT Gene

Domains for VIT Gene

Protein Domains for VIT Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for VIT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXI7

UniProtKB/Swiss-Prot:

VITRN_HUMAN
Domain:
  • Contains 1 LCCL domain.:
    • Q6UXI7
  • Contains 2 VWFA domains.:
    • Q6UXI7
genes like me logo Genes that share domains with VIT: view

No data available for Gene Families for VIT Gene

Function for VIT Gene

Molecular function for VIT Gene

UniProtKB/Swiss-Prot Function: Promotes matrix assembly and cell adhesiveness.

Gene Ontology (GO) - Molecular Function for VIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005539 glycosaminoglycan binding IEA --
genes like me logo Genes that share ontologies with VIT: view

Phenotypes for VIT Gene

GenomeRNAi human phenotypes for VIT:
genes like me logo Genes that share phenotypes with VIT: view

miRNA for VIT Gene

miRTarBase miRNAs that target VIT

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for VIT Gene

Localization for VIT Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIT Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VIT Gene COMPARTMENTS Subcellular localization image for VIT gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for VIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005614 interstitial matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with VIT: view

Pathways for VIT Gene

genes like me logo Genes that share pathways with VIT: view

Interacting Proteins for VIT Gene

Gene Ontology (GO) - Biological Process for VIT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with VIT: view

Transcripts for VIT Gene

Unigene Clusters for VIT Gene

Vitrin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VIT Gene

No ASD Table

Relevant External Links for VIT Gene

GeneLoc Exon Structure for
VIT
ECgene alternative splicing isoforms for
VIT

Expression for VIT Gene

mRNA expression in normal human tissues for VIT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIT Gene

This gene is overexpressed in Nerve - Tibial (7.5) and Adipose - Subcutaneous (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for VIT Gene

SOURCE GeneReport for Unigene cluster for VIT Gene Hs.137415

genes like me logo Genes that share expressions with VIT: view

No data available for mRNA Expression by UniProt/SwissProt for VIT Gene

Orthologs for VIT Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VIT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VIT 35
  • 85.84 (n)
  • 84.05 (a)
VIT 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VIT 35
  • 87.83 (n)
  • 86.44 (a)
VIT 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vit 35
  • 85.18 (n)
  • 84.77 (a)
Vit 16
Vit 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VIT 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VIT 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vit 35
  • 84.39 (n)
  • 85.32 (a)
chicken
(Gallus gallus)
Aves VIT 35
  • 71.14 (n)
  • 68.44 (a)
VIT 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VIT 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489513 35
  • 66.07 (n)
  • 63.1 (a)
zebrafish
(Danio rerio)
Actinopterygii ch1073-291c23.1 35
  • 64.17 (n)
  • 62.08 (a)
ch1073-291c23.1 36
  • 50 (a)
OneToOne
Species with no ortholog for VIT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIT Gene

ENSEMBL:
Gene Tree for VIT (if available)
TreeFam:
Gene Tree for VIT (if available)

Paralogs for VIT Gene

Paralogs for VIT Gene

Selected SIMAP similar genes for VIT Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VIT: view

Variants for VIT Gene

Sequence variations from dbSNP and Humsavar for VIT Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs721348 -- 36,719,290(-) GTAGG(C/T)ATCCT intron-variant
rs721349 -- 36,719,529(-) ttagt(G/T)tatag intron-variant
rs721350 -- 36,719,465(-) CATTT(A/G)TTAGT intron-variant
rs721351 -- 36,719,431(-) TTTAG(G/T)GCTTT intron-variant
rs759426 -- 36,706,310(-) TATGT(C/T)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VIT Gene

Variant ID Type Subtype PubMed ID
nsv873878 CNV Loss 21882294
esv2719924 CNV Deletion 23290073
esv9230 CNV Loss 19470904
esv1427533 CNV Deletion 17803354
nsv525132 CNV Loss 19592680
nsv820661 CNV Deletion 20802225
nsv828920 CNV Loss 20364138
esv2668900 CNV Deletion 23128226
esv24650 CNV Gain 19812545
nsv819346 CNV Gain 19587683
nsv428395 CNV Gain 18775914
dgv694e199 CNV Deletion 23128226
esv1722218 CNV Insertion 17803354
nsv2682 CNV Loss 18451855

Relevant External Links for VIT Gene

HapMap Linkage Disequilibrium report
VIT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIT Gene

Disorders for VIT Gene

(2) University of Copenhagen DISEASES for VIT Gene

Relevant External Links for VIT

Genetic Association Database (GAD)
VIT
Human Genome Epidemiology (HuGE) Navigator
VIT
genes like me logo Genes that share disorders with VIT: view

No data available for UniProtKB/Swiss-Prot for VIT Gene

Publications for VIT Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. (PMID: 12388743) Whittaker C.A. … Hynes R.O. (Mol. Biol. Cell 2002) 3 23

Products for VIT Gene

Sources for VIT Gene

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