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VIT Gene

protein-coding   GIFtS: 46

GC02P036835
vitrin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp313L1517 2
H_NH0294L11.1 2
MGC149746 2
MGC70561 2
WUGSC:H_NH0294L11.1 2
vitrin 2
External Ids
HGNC: 126971
Entrez Gene: 52122
UniProtKB: Q6UXI73
Ensembl: ENSG000002052217
Search outside databases for aliases for VIT gene

Previous GC identifers: GC02P036888 GC02P037070 GC02P036898

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7
Function: Promotes matrix assembly and cell adhesiveness (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VIT gene  

Entrez Gene cytogenetic band: 2p22-p21   Ensembl cytogenetic band:  2p22.2   HGNC cytogenetic band: 2p22.2

VIT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P036835:     (about GC identifiers)

Start:
36,777,411 bp from pter
End:
36,895,433 bp from pter
Size:
118,023 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7 (See protein sequence)
Recommended Name: Vitrin precursor  
Size: 678 amino acids; 73930 Da
Subunit: Binds dermatan sulfate and chondroitin sulfate (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: A8K7Y4 Q6P7T3 Q96DT1
Alternative splicing: 3 isoforms:  Q6UXI7-1   Q6UXI7-2   Q6UXI7-3   

REFSEQ proteins: NP_444506.2  

ENSEMBL proteins: 
ENSP00000384710 ENSP00000385658 ENSP00000384154 ENSP00000368544 ENSP00000374625 ENSP00000368543 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (VIT)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005578 proteinaceous extracellular matrix IEA--
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Antibodies for VIT: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for VIT

Assays for VIT: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR004043 LCCL
 IPR002035 VWF_A


   GeneDecks  VIT for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q6UXI7

ProtoNet protein and cluster: Q6UXI7

1 Blocks protein family: IPB004043 LCCL domain

UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7
Similarity: Contains 1 LCCL domain
Similarity: Contains 2 VWFA domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (VIT)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053276

              Applied Biosystems Silencer® siRNAs for VIT

              Sigma-Aldrich siRNA for VIT  
                     Sigma-Aldrich shRNA for VIT  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for VIT
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_053276
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_053276
                                 untagged cDNA clone in CMV expression vector: NM_053276 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_053276

UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7
Function: Promotes matrix assembly and cell adhesiveness (By similarity)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for VIT (ENSP000003685443) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
ITIH5ENSP000002568613STRING (score=.901)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VIT

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (VIT)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053276

              Sigma-Aldrich siRNA for VIT  
                     Sigma-Aldrich shRNA for VIT  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_053276  

REFSEQ mRNAs for VIT gene: 

NM_053276.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_053276  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_053276
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_053276
                                 untagged cDNA clone in CMV expression vector: NM_053276 

Additional cDNA sequence: 

AF063833.1 AK056772.1 AK292149.1 AK299426.1 AL832679.1 AY358338.1 BC061519.1 BC128260.1 

7 DOTS entries:

DT.437920  DT.40316582  DT.100736925  DT.100746868  DT.100023037  DT.97811644  DT.99976703 

24/56 AceView cDNA sequences (see all 56 ):

BU737859 BM712204 BF726421 CD679226 AW316554 AA227978 AY358338 BF037138 
BF727228 AA687616 CA421947 BX099804 AL832679 AA346825 BM700383 BF726449 
NM_053276 AK056772 BM670265 BM700057 BE743922 BQ575831 AF063833 BF726450 

highest scoring ESTs for VIT:

AI817458 AA227978 AA228126 AA687616 AF063833 AI271432 AI810494 AK056772 AW316554 AW351633 

Unigene Cluster for VIT:

Vitrin
Hs.137415  [show with all ESTs]
Unigene Representative Sequence: AY358338


GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:
ENST00000402257  ENST00000401530  ENST00000404084  ENST00000379242  ENST00000389975  ENST00000379241  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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VIT expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for VIT

1 / 2 / 3

3 probe-sets matching VIT gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
82460_at2, 3 U95-E 1 1.00 1.00 1.00 1.00 AI817458 1.00 1.00 1.00 1

227899_at2, 3 U133-B 1 1.00 1.00 -- -- AI817458 1.00 1.00 1.00 1

227899_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  VIT for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGCACAGAAA

SOURCE GeneReport for Unigene cluster: Hs.137415
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for VIT gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
VIT1   -- vitrin 87.72(n)
86.59(a)
483032  XM_540147.2  XP_540147.2 
cow
(Bos taurus)
VIT1   -- vitrin 85.84(n)
84.05(a)
280957  NM_173971.2  NP_776396.1 
rat
(Rattus norvegicus)
Vit1   -- vitrin 84.34(n)
85.23(a)
313831  XM_233802.4  XP_233802.4 
mouse
(Mus musculus)
Vit1, 5 175
vitrin1, 5 85.18(n)1
84.77(a)1
741991  NM_028813.11  NP_083089.11 
 AF4547555  AK0131935  (see all 10)
chicken
(Gallus gallus)
VIT1   -- vitrin 70.47(n)
67.54(a)
421471  NM_001024580.1  NP_001019751.1 
About this table        Species with no ortholog for VIT

ENSEMBL Gene Tree for VIT
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for VIT gene
COCH2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/866 NCBI SNPs in VIT are shown (see all 866 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 360)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs119012021,2
A,C,F,H36894943(+) ACCTCC/TATCAG 1 H/Y mis1 ese313Minor allele frequency- T:0.11EU EA WA NA 1332
rs75637541,2
A,C,F,H36777544(+) TGCAGG/AAAAGC 1 -- ut51 ese38Minor allele frequency- A:0.17EU EA WA 838
rs20725261,2
C,F,H36889438(-) CAGGCC/TTGCTG 1 K/R mis113Minor allele frequency- N:0.00EA NA EU WA 1126
rs20725251,2
C,F,H36889449(-) GTTGAG/TGATGT 1 L/I mis1 ese312Minor allele frequency- T:0.07NA EU EA WA 1050
--
rs118997171,2
A,C36776045(+) CTTTAA/TTGGAG 1 -- ng510--------
rs67112001,2
A,C36776581(+) CTCCTC/TCCTAG 1 -- ng51 trp30--------
--
rs67076371,2
A,C36776051(+) TGGAGC/GAAGAT 1 -- ng510--------
--
rs75737651,2
C36776459(+) AGCAAC/TCATCC 1 -- ng510--------
--
rs46706201,2
A36895714(+) CCAGGA/CGCGGG 1 -- ng310--------
--
rs65440261,2
C36777402(+) GTGTGG/TGGGGG 1 -- ng51 tfbs30--------
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HapMap Linkage Disequilibrium images for VIT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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7 PubMed articles for VIT gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5212 HGNC: 12697 AceView: VIT Ensembl:ENSG00000205221 euGenes: HUgn5212
ECgene: VIT H-InvDB: VIT
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for VIT:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VIT-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for VIT Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for VIT Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins (VIT)
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for VIT

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