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Aliases &
Descriptions
for VIT
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| DKFZp313L1517 2 | | H_NH0294L11.1 2 | | MGC149746 2 | | MGC70561 2 | | WUGSC:H_NH0294L11.1 2 | | vitrin 2 |
| | |
| |
Search outside databases for aliases for VIT genePrevious GC identifers: GC02P036888 GC02P037070 GC02P036898 |
Summaries
for VIT(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7Function: Promotes matrix assembly and cell adhesiveness (By similarity) |
Genomic Location
for VIT
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the VIT gene 
Entrez Gene cytogenetic band: 2p22-p21 Ensembl cytogenetic band: 2p22.2 HGNC cytogenetic band: 2p22.2VIT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P036835:
(about GC identifiers)
Start:
|
36,777,411 bp from pter |
End:
|
36,895,433 bp from pter |
Size:
|
118,023 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins
for VIT
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7 (See
protein sequence)Recommended Name: Vitrin precursor Size: 678 amino acids; 73930 Da
Subunit: Binds dermatan sulfate and chondroitin sulfate (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: A8K7Y4 Q6P7T3 Q96DT1Alternative splicing: 3 isoforms: Q6UXI7-1 Q6UXI7-2 Q6UXI7-3 REFSEQ proteins: NP_444506.2
ENSEMBL proteins: ENSP00000384710 ENSP00000385658 ENSP00000384154 ENSP00000368544 ENSP00000374625 ENSP00000368543
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005578 | proteinaceous extracellular matrix |
IEA | -- |
About this table
Antibodies for VIT:
Assays for VIT: | Protein
Domains/
Families
for VIT(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6UXI7
ProtoNet protein and cluster: Q6UXI7 1 Blocks protein family: IPB004043 LCCL domain
UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7Similarity: Contains 1 LCCL domainSimilarity: Contains 2 VWFA domains | Gene Function
for VIT
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053276
 Applied Biosystems Silencer® siRNAs for VIT
 Sigma-Aldrich siRNA for VIT
Sigma-Aldrich shRNA for VIT
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_053276
Myc/DDK tagged cDNA clone in CMV expression vector: NM_053276
untagged cDNA clone in CMV expression vector: NM_053276
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_053276
UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7Function: Promotes matrix assembly and cell adhesiveness (By similarity) | Pathways & Interactions
for VIT
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for VIT (ENSP000003685443) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds
for VIT(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for VIT
|
Transcripts
for VIT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053276
Sigma-Aldrich siRNA for VIT
Sigma-Aldrich shRNA for VIT
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_053276 REFSEQ mRNAs for VIT gene: NM_053276.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_053276
OriGene GFP tagged cDNA clone in CMV expression vector: NM_053276
Myc/DDK tagged cDNA clone in CMV expression vector: NM_053276
untagged cDNA clone in CMV expression vector: NM_053276
Additional cDNA sequence: AF063833.1 AK056772.1 AK292149.1 AK299426.1 AL832679.1 AY358338.1 BC061519.1 BC128260.1 7 DOTS entries: DT.437920 DT.40316582 DT.100736925 DT.100746868 DT.100023037 DT.97811644 DT.99976703 24/56 AceView cDNA sequences (see all 56
):BU737859 BM712204 BF726421 CD679226 AW316554 AA227978 AY358338 BF037138 BF727228 AA687616 CA421947 BX099804 AL832679 AA346825 BM700383 BF726449 NM_053276 AK056772 BM670265 BM700057 BE743922 BQ575831 AF063833 BF726450
 highest scoring ESTs for VIT:AI817458 AA227978 AA228126 AA687616 AF063833 AI271432 AI810494 AK056772 AW316554 AW351633 Unigene Cluster for VIT: Vitrin Hs.137415 [show with all ESTs]Unigene Representative Sequence: AY358338
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations: ENST00000402257
ENST00000401530
ENST00000404084
ENST00000379242
ENST00000389975
ENST00000379241
|
Expression
for VIT
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VIT expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VIT
1 / 2 / 3 3 probe-sets matching VIT gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGCACAGAAA
SOURCE GeneReport for Unigene cluster: Hs.137415
|
Orthologs
for VIT
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VIT gene from 5/7 species (see all 7
)
About this table Species with no ortholog for VIT
ENSEMBL Gene Tree for VIT | Paralogs
for VIT(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for VIT gene
- COCH2
|
SNPs/Variants
for VIT(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VIT (up to first 250kb)
|
Disorders & Mutations
for VIT
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News
for VIT(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for VIT (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for VIT gene:- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- VIT-1: the second member of a new branch of the von Willebrand factor A domain superfamily. (PubMed id 10830112)3, 4 Mayne R.... Narayana S. (1999)
- Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. (PubMed id 12388743)1, 3 Whittaker C.A. and Hynes R.O. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)3 (1998)
|
Search for VIT
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VIT
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VIT
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VIT(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for VIT(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for VIT:
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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