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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VIT Gene

protein-coding GIFtS: 48
GCID: GC02P036835

vitrin

Explore 1 disease affiliated with
VIT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Vitrin¹

External Ids:	HGNC: 12697¹	Entrez Gene: 5212²	Ensembl: ENSG00000205221⁷	UniProtKB: Q6UXI7³

Export aliases for VIT gene to outside databases

Previous GC identifers: GC02P036888 GC02P037070 GC02P036898 GC02P036664

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7

Function: Promotes matrix assembly and cell adhesiveness (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VIT gene promoter:
STAT5B STAT1 AML1a STAT4 STAT6 STAT1beta STAT5A STAT1alpha STAT2 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VIT promoter sequence

Search SABiosciences Chromatin IP Primers for VIT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VIT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.2 Ensembl cytogenetic band: 2p22.2 HGNC cytogenetic band: 2p22.2

VIT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIT gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P036835: view genomic region (about GC identifiers)

Start:	36,923,833 bp from pter	End:	37,041,937 bp from pter
Size:	118,105 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7 (See protein sequence)

Recommended Name: Vitrin precursor

Size: 678 amino acids; 73930 Da

Subunit: Binds dermatan sulfate and chondroitin sulfate (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: A1A526 A6NKI9 A8K7Y4 E9PF47 Q6P7T3 Q96DM8 Q96DT1 Q9UDN0

Alternative splicing: 5 isoforms: Q6UXI7-1 Q6UXI7-2 Q6UXI7-3 Q6UXI7-4 Q6UXI7-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VIT: NX_Q6UXI7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UXI7

VIT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001171440.1 NP_001171441.1 NP_001171442.1 NP_001171443.1 NP_444506.2

ENSEMBL proteins:

ENSP00000368544 ENSP00000393561 ENSP00000417874 ENSP00000384154 ENSP00000368543

ENSP00000385658 ENSP00000419251 ENSP00000374625

Human Recombinant Protein Products for VIT:

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	Novus Biologicals VIT Protein Novus Biologicals VIT Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VIT

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	--	--
GO:0005614	interstitial matrix	IEA	--
GO:0031012	extracellular matrix	--	--

VIT for ontologies About GeneDecksing

VIT Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for VIT
	Abcam antibodies for VIT
	Uscn Antibodies for VIT
	ThermoFisher Antibodies for VIT

Assay Products for VIT:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VIT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VIT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VIT for domains About GeneDecksing

2 InterPro domains/families:

IPR004043 LCCL

IPR002035 VWF_A

Graphical View of Domain Structure for InterPro Entry Q6UXI7

ProtoNet protein and cluster: Q6UXI7

1 Blocks protein family: IPB004043 LCCL domain

UniProtKB/Swiss-Prot: VITRN_HUMAN, Q6UXI7

Similarity: Contains 1 LCCL domain

Similarity: Contains 2 VWFA domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: VITRN_HUMAN, Q6UXI7

Function: Promotes matrix assembly and cell adhesiveness (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005539	glycosaminoglycan binding	IEA	--

VIT for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for VIT:

Increased gamma-H2AX phosphory

Proliferating cells

1 MGI phenotypic allele

for Vit (no phenotypes)

VIT for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Vit^tm1Lex for VIT

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VIT

miRNA Products:		OriGene 3'-UTR Clone: VIT Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIT
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate VIT:
		hsa-miR-221* hsa-miR-425 hsa-miR-3662 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: VIT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VIT (see all 4) OriGene shRNA RFP: VIT OriGene siRNA: VIT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIT
		Sirion Biotech Custom design and validation of potent shRNA sequences against VIT

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for VIT
			Sirion Biotech Customized adenovirus for overexpression of VIT Sirion Biotech Customized adenovirus for potent knockdown of VIT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VIT (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VIT (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): VIT (NM_053276)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VIT
		Search LifeMap BioReagents cell lines for VIT
		Sirion Biotech Customized stable knockdown cell line services for VIT Sirion Biotech Customized inducible knockdown cell line services for VIT Sirion Biotech Customized stable overexpressing cell line services for VIT Sirion Biotech Customized inducible overexpressing cell line services for VIT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIT

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for VIT

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010811	positive regulation of cell-substrate adhesion	IEA	--
GO:0030198	extracellular matrix organization	IEA	--

VIT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VIT
Search CenterWatch for drugs/clinical trials and news about VIT / VITRN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VIT gene (5 alternative transcripts):

NM_001177969.1 NM_001177970.1 NM_001177971.1 NM_001177972.1 NM_053276.3

Unigene Cluster for VIT:

Vitrin

Hs.137415 [show with all ESTs]

Unigene Representative Sequence: NM_053276

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379242(uc002rpl.3) ENST00000457137(uc002rpk.3) ENST00000497382

ENST00000404084 ENST00000379241 ENST00000401530 ENST00000464309 ENST00000389975(uc010ynf.2 uc002rpm.3 uc010ezv.3 uc010ezw.3)

miRNA Products:		OriGene 3'-UTR Clone: VIT Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIT
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate VIT:
		hsa-miR-221* hsa-miR-425 hsa-miR-3662 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: VIT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VIT (see all 4) OriGene shRNA RFP: VIT OriGene siRNA: VIT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIT
		Sirion Biotech Custom design and validation of potent shRNA sequences against VIT

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VIT (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VIT (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): VIT (NM_053276)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VIT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat VIT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIT

Additional cDNA sequence:

AF063833.1 AK056772.1 AK292149.1 AK299426.1 AL832679.1 AY358338.1 BC061519.1 BC128260.1

7 DOTS entries:

DT.437920 DT.40316582 DT.100736925 DT.100746868 DT.100023037 DT.97811644 DT.99976703

24/56 AceView cDNA sequences (see all 56):

BU737859 AK056772 NM_053276 CA421947 BF726449 BM712204 BX099804 AW316554

CD679226 BF037138 BM670265 BF726421 BM700383 AL832679 AA227978 BM700057

BF727228 AA346825 AA687616 AY358338 BF726450 BE743922 BC061519 CD516878

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VIT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCACAGAAA

About this image

VIT expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

See VIT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VIT

SOURCE GeneReport for Unigene cluster: Hs.137415

SABiosciences Custom PCR Arrays for VIT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VIT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat VIT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIT

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for VIT gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	VIT¹	vitrin	70.5(n) 68.01(a)		421471 NM_001024580.1 NP_001019751.1
lizard (Anolis carolinensis)	Reptilia	VIT⁶	--	66(a)	1 ↔ 1	1(232746859-232781441)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX735553.1²	--	74.26(n)		BX735553.1
zebrafish (Danio rerio)	Actinopterygii	ch1073-291c23.1¹	ch1073-291c23.1	61.6(n) 57.37(a)		497398 XM_002664064.2 XP_002664110.2

ENSEMBL Gene Tree for VIT (if available)
TreeFam Gene Tree for VIT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VIT gene

VWA1² MATN4² COL14A1² COL9A1² MATN3² MATN2² COL12A1² COL9A3²

COCH² COL9A2² COL20A1² VWA2² COL21A1² MATN1²

5 SIMAP similar genes for VIT using alignment to 4 protein entries: VITRN_HUMAN (see all proteins):

ITGA2 COL21A1 COCH COL6A6 COL6A5

VIT for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139638328^1,2	C	--	36921956(+)	`CTAGC-/ATTATTAT`	5	--	us2k¹		0	--	--	--	--
rs79540079^1,2	C	--	36921980(+)	`TTATT-/ATTTTTTG`	5	--	us2k¹		0	--	--	--	--
rs199602549^1,2		--	36922148(+)	`ATTTT-/TGG TAGAGATGGGG`	5	--	us2k¹		0	--	--	--	--
rs4346362^1,2		--	36922167(+)	`tttcaC/Gcatgt`	5	--	us2k¹		0	--	--	--	--
rs150001518^1,2		--	36922264(+)	`GAGTCC/TAGCAG`	5	--	us2k¹		0	--	--	--	--
rs193017782^1,2		--	36922292(+)	`TTAGGA/GATAAT`	5	--	us2k¹		0	--	--	--	--
rs145201683^1,2		--	36922436(+)	`AAAGAG/TGATTG`	5	--	us2k¹		0	--	--	--	--
rs11899717^1,2	C,F,A,H	--	36922541(+)	`CTTTAA/TTGGAG`	5	--	us2k¹		8		NA WA CSA EA	368
rs6707637^1,2	C,A,H	--	36922547(+)	`TGGAGC/GAAGAT`	5	--	us2k¹		12		NA WA CSA	256
rs185695912^1,2		--	36922622(+)	`ATCTAC/GATAGC`	5	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VIT (36923833 - 37041937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for VIT
2 CNVs: 58986 67478
3 Indels: 26680 40323 61760

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VIT

DNA2.0 Custom Variant and Variant Library Synthesis for VIT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VIT for disorders About GeneDecksing

1 disease for VIT: About MalaCards

mastocytosis

2 diseases from the University of Copenhagen DISEASES database for VIT:

Hypersensitivity reaction type I disease Mastocytosis

Human Genome Epidemiology (HuGE) Navigator: VIT (4 documents)

Export disorders for VIT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VIT gene integrated from 9 sources:
(articles sorted by number of sources associating them with VIT)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
VIT-1: the second member of a new branch of the von Willebrand factor A domain superfamily. (PubMed id 10830112)^{1, 2} Mayne R.... Narayana S. (1999)
Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. (PubMed id 12388743)^{1, 9} Whittaker C.A. and Hynes R.O. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PubMed id 12766061)¹ Tomarev S.I....Malyukova I. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Toward a complete human genome sequence. (PubMed id 9847074)¹ Wilson R. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5212	HGNC: 12697	AceView: VIT	Ensembl:ENSG00000205221	euGenes: HUgn5212
ECgene: VIT	H-InvDB: VIT

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VIT	Pharmacogenomics, SNPs, Pathways

Intellectual Property for VIT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for VIT gene:
Search GeneIP for patents involving VIT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for VIT
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VIT		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VIT
	OriGene Protein Over-expression Lysate for VIT		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for VIT		OriGene 3'-UTR Clone for VIT
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VIT		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VIT
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for VIT		OriGene Custom Protein Services for VIT
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VIT
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VIT
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VIT
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIT
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIT
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIT

	GenScript Custom Purified and Recombinant Proteins Services for VIT		GenScript cDNA clones with any tag delivered in your preferred vector for VIT
	GenScript Custom Assay Services for VIT		GenScript Custom Superior Antibodies Services for VIT
	GenScript Custom overexpressing Cell Line Services for VIT		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in VIT promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	VIT proteins
	VIT lysates

	Antibodies for VIT
	See all of Abcam's Antibodies, Kits and Proteins for VIT
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Browse ProSpec Recombinant Proteins

VIT Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for VIT

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIT

	SwitchGear 3'UTR luciferase reporter plasmids for VIT
	SwitchGear Promoter luciferase reporter plasmids for VIT

ThermoFisher Antibodies for VIT

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIT

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VIT

Sirion Biotech Customized:

	stable knockdown cell line services for VIT
	inducible knockdown cell line services for VIT
	design and validation of potent shRNA sequences against VIT
	adenovirus for potent knockdown of VIT
	adenovirus for overexpression of VIT
	stable overexpressing cell line services for VIT
	inducible overexpressing cell line services for VIT

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes VIT gene at Home site.

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VIT Gene

vitrin

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Function
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Expression
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Export list of displayed genes

VIT Gene

vitrin

Aliasesfor VIT gene

Summariesfor VIT gene

Genomic Viewsfor VIT gene

Proteinsfor VIT gene

Protein Domains /Familiesfor VIT gene

Functionfor VIT gene

Pathways & Interactionsfor VIT gene

Drugs & Compoundsfor VIT gene

Transcriptsfor VIT gene

Expression for VIT gene

Orthologsfor VIT gene

Paralogsfor VIT gene

Genomic Variantsfor VIT gene

Disorders / Diseasesfor VIT gene

Publicationsfor VIT gene

External Searches for VIT gene

Genome Databases showing VIT gene

Other Databases showing VIT gene

Specialized Databases showing VIT gene

Intellectual Propertyfor VIT gene

Productsfor VIT gene

View Random Gene

Aliases
for VIT gene

Summaries
for VIT gene

Genomic Views
for VIT gene

Proteins
for VIT gene

Protein Domains /
Families
for VIT gene

Function
for VIT gene

Pathways & Interactions
for VIT gene

Drugs & Compounds
for VIT gene

Transcripts
for VIT gene

Expression
for VIT gene

Orthologs
for VIT gene

Paralogs
for VIT gene

Genomic Variants
for VIT gene

Disorders / Diseases
for VIT gene

Publications
for VIT gene

Intellectual Property
for VIT gene

Products
for VIT gene