Free for academic non-profit institutions. Other users need a Commercial license

Aliases for VIT Gene

Aliases for VIT Gene

External Ids for VIT Gene

Previous GeneCards Identifiers for VIT Gene

  • GC02P036888
  • GC02P037070
  • GC02P036898
  • GC02P036835

Summaries for VIT Gene

GeneCards Summary for VIT Gene

VIT (Vitrin) is a Protein Coding gene. GO annotations related to this gene include glycosaminoglycan binding. An important paralog of this gene is MATN1.

UniProtKB/Swiss-Prot for VIT Gene

  • Promotes matrix assembly and cell adhesiveness.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIT Gene

Genomics for VIT Gene

Regulatory Elements for VIT Gene

Enhancers for VIT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VIT on UCSC Golden Path with GeneCards custom track

Promoters for VIT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VIT on UCSC Golden Path with GeneCards custom track

Genomic Location for VIT Gene

36,696,690 bp from pter
36,814,794 bp from pter
118,105 bases
Plus strand

Genomic View for VIT Gene

Genes around VIT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VIT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VIT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIT Gene

Proteins for VIT Gene

  • Protein details for VIT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1A526
    • A6NKI9
    • A8K7Y4
    • E9PF47
    • Q6P7T3
    • Q96DM8
    • Q96DT1
    • Q9UDN0

    Protein attributes for VIT Gene

    678 amino acids
    Molecular mass:
    73930 Da
    Quaternary structure:
    • Binds dermatan sulfate and chondroitin sulfate.

    Alternative splice isoforms for VIT Gene


neXtProt entry for VIT Gene

Proteomics data for VIT Gene at MOPED

Post-translational modifications for VIT Gene

  • Glycosylation at Asn 390 and Asn 520
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VIT Gene

Domains & Families for VIT Gene

Protein Domains for VIT Gene


Suggested Antigen Peptide Sequences for VIT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LCCL domain.
  • Contains 1 LCCL domain.
  • Contains 2 VWFA domains.
genes like me logo Genes that share domains with VIT: view

No data available for Gene Families for VIT Gene

Function for VIT Gene

Molecular function for VIT Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly and cell adhesiveness.
genes like me logo Genes that share phenotypes with VIT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for VIT

miRNA for VIT Gene

miRTarBase miRNAs that target VIT

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VIT Gene

Localization for VIT Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIT Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for VIT Gene COMPARTMENTS Subcellular localization image for VIT gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for VIT Gene

Pathways & Interactions for VIT Gene

SuperPathways for VIT Gene

No Data Available

Interacting Proteins for VIT Gene

Gene Ontology (GO) - Biological Process for VIT Gene


No data available for Pathways by source and SIGNOR curated interactions for VIT Gene

Drugs & Compounds for VIT Gene

No Compound Related Data Available

Transcripts for VIT Gene

Unigene Clusters for VIT Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VIT Gene

No ASD Table

Relevant External Links for VIT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VIT Gene

mRNA expression in normal human tissues for VIT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIT Gene

This gene is overexpressed in Nerve - Tibial (x7.5) and Adipose - Subcutaneous (x4.6).

Protein differential expression in normal tissues from HIPED for VIT Gene

This gene is overexpressed in Prostate (19.0), Oral epithelium (9.3), Adipocyte (7.2), Spinal cord (6.7), Testis (6.5), and Gallbladder (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for VIT Gene

SOURCE GeneReport for Unigene cluster for VIT Gene Hs.137415

genes like me logo Genes that share expression patterns with VIT: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for VIT Gene

Orthologs for VIT Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VIT 35
  • 85.84 (n)
  • 84.05 (a)
VIT 36
  • 84 (a)
(Canis familiaris)
Mammalia VIT 35
  • 87.83 (n)
  • 86.44 (a)
VIT 36
  • 86 (a)
(Mus musculus)
Mammalia Vit 35
  • 85.18 (n)
  • 84.77 (a)
Vit 16
Vit 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Vit 35
  • 84.39 (n)
  • 85.32 (a)
(Monodelphis domestica)
Mammalia VIT 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia VIT 36
  • 70 (a)
(Pan troglodytes)
Mammalia VIT 36
  • 99 (a)
(Gallus gallus)
Aves VIT 35
  • 71.14 (n)
  • 68.44 (a)
VIT 36
  • 62 (a)
(Anolis carolinensis)
Reptilia VIT 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489513 35
  • 66.07 (n)
  • 63.1 (a)
(Danio rerio)
Actinopterygii ch1073-291c23.1 35
  • 64.17 (n)
  • 62.08 (a)
ch1073-291c23.1 36
  • 50 (a)
Species with no ortholog for VIT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIT Gene

Gene Tree for VIT (if available)
Gene Tree for VIT (if available)

Paralogs for VIT Gene

(5) SIMAP similar genes for VIT Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VIT: view

Variants for VIT Gene

Sequence variations from dbSNP and Humsavar for VIT Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2072526 - 36,808,791(-) CAGGC(C/T)TGCTG reference, missense
rs2072525 - 36,808,802(-) GTTGA(G/T)GATGT reference, missense
rs11901202 - 36,814,296(+) ACCTC(C/T)ATCAG reference, missense
rs721348 -- 36,719,290(-) GTAGG(C/T)ATCCT intron-variant
rs721349 -- 36,719,529(-) ttagt(G/T)tatag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VIT Gene

Variant ID Type Subtype PubMed ID
nsv873878 CNV Loss 21882294
esv2719924 CNV Deletion 23290073
esv9230 CNV Loss 19470904
esv1427533 CNV Deletion 17803354
nsv525132 CNV Loss 19592680
nsv820661 CNV Deletion 20802225
nsv828920 CNV Loss 20364138
esv2668900 CNV Deletion 23128226
esv24650 CNV Gain 19812545
nsv819346 CNV Gain 19587683
nsv428395 CNV Gain 18775914
dgv694e199 CNV Deletion 23128226
esv1722218 CNV Insertion 17803354
nsv2682 CNV Loss 18451855

Variation tolerance for VIT Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.38; 92.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VIT Gene

Disorders for VIT Gene

Relevant External Links for VIT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VIT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VIT Gene

Publications for VIT Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. (PMID: 12388743) Whittaker C.A. … Hynes R.O. (Mol. Biol. Cell 2002) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. (PMID: 12766061) Tomarev S.I. … Malyukova I. (Invest. Ophthalmol. Vis. Sci. 2003) 3

Products for VIT Gene

Sources for VIT Gene