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Aliases for VIPR2 Gene

Aliases for VIPR2 Gene

  • Vasoactive Intestinal Peptide Receptor 2 2 3 5
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type III Receptor 3 4
  • Helodermin-Preferring VIP Receptor 3 4
  • VIP And PACAP Receptor 2 2 3
  • PACAP Type III Receptor 3 4
  • PACAP-R-3 3 4
  • PACAP-R3 3 4
  • VIP-R-2 3 4
  • VPAC2 3 4
  • C16DUPq36.3 3
  • DUP7q36.3 3
  • VPCAP2R 3
  • VPAC2R 3
  • VIP2R 4

External Ids for VIPR2 Gene

Previous GeneCards Identifiers for VIPR2 Gene

  • GC07M157122
  • GC07M158123
  • GC07M158237
  • GC07M158320
  • GC07M158513
  • GC07M158820
  • GC07M152560

Summaries for VIPR2 Gene

Entrez Gene Summary for VIPR2 Gene

  • This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]

GeneCards Summary for VIPR2 Gene

VIPR2 (Vasoactive Intestinal Peptide Receptor 2) is a Protein Coding gene. Diseases associated with VIPR2 include Schizophrenia 16 and Holoprosencephaly-3. Among its related pathways are cAMP signaling pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is MGC57346-CRHR1.

UniProtKB/Swiss-Prot for VIPR2 Gene

  • This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

Tocris Summary for VIPR2 Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.

Gene Wiki entry for VIPR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIPR2 Gene

Genomics for VIPR2 Gene

Regulatory Elements for VIPR2 Gene

Enhancers for VIPR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VIPR2 on UCSC Golden Path with GeneCards custom track

Promoters for VIPR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VIPR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for VIPR2 Gene

Chromosome:
7
Start:
159,028,175 bp from pter
End:
159,144,957 bp from pter
Size:
116,783 bases
Orientation:
Minus strand

Genomic View for VIPR2 Gene

Genes around VIPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VIPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VIPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIPR2 Gene

Proteins for VIPR2 Gene

  • Protein details for VIPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41587-VIPR2_HUMAN
    Recommended name:
    Vasoactive intestinal polypeptide receptor 2
    Protein Accession:
    P41587
    Secondary Accessions:
    • Q13053
    • Q15870
    • Q53Y09
    • Q6ZN22
    • Q9UCW0

    Protein attributes for VIPR2 Gene

    Size:
    438 amino acids
    Molecular mass:
    49479 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIPR2 Gene

    Alternative splice isoforms for VIPR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VIPR2 Gene

Proteomics data for VIPR2 Gene at MOPED

Post-translational modifications for VIPR2 Gene

  • Glycosylation at Asn 58, Asn 88, and Asn 92
  • Modification sites at PhosphoSitePlus

Other Protein References for VIPR2 Gene

Antibody Products

No data available for DME Specific Peptides for VIPR2 Gene

Domains & Families for VIPR2 Gene

Graphical View of Domain Structure for InterPro Entry

P41587

UniProtKB/Swiss-Prot:

VIPR2_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with VIPR2: view

Function for VIPR2 Gene

Molecular function for VIPR2 Gene

GENATLAS Biochemistry:
vasoactive intestinal peptide,also responding to the pituitary adenylate cyclase activating polypeptide in stimulating cAMP production,receptor 2,G protein coupled,secretin receptor superfamily
UniProtKB/Swiss-Prot Function:
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.
genes like me logo Genes that share phenotypes with VIPR2: view

Animal Models for VIPR2 Gene

MGI Knock Outs for VIPR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for VIPR2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for VIPR2 Gene

Localization for VIPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIPR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VIPR2 Gene COMPARTMENTS Subcellular localization image for VIPR2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for VIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with VIPR2: view

Pathways & Interactions for VIPR2 Gene

genes like me logo Genes that share pathways with VIPR2: view

Pathways by source for VIPR2 Gene

Gene Ontology (GO) - Biological Process for VIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048662 negative regulation of smooth muscle cell proliferation IEA --
genes like me logo Genes that share ontologies with VIPR2: view

No data available for SIGNOR curated interactions for VIPR2 Gene

Drugs & Compounds for VIPR2 Gene

(23) Drugs for VIPR2 Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Secretin Approved, Investigational Pharma Full agonist, Agonist, binder 30
BAY 55-9837 Pharma Agonist Potent and selective VPAC2 agonist 0
[<sup>125</sup>I]BAY 55-9837 Pharma Agonist 0
[<sup>125</sup>I]PACAP-27 Pharma Agonist 0
[Ala<sup>11,22,28</sup>]VIP Pharma Agonist 0

(7) Additional Compounds for VIPR2 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]VIP
Full agonist, Agonist
[Lys<sup>15</sup>,Arg<sup>16</sup>,Leu<sup>27</sup>]VIP-(1?ao7)/GRF-(8?ao27)-NH<sub>2</sub>
Full agonist, Agonist
[Ala11,22,28]VIP
291524-04-4
PHM 27 (human)
118025-43-7
VIP (guinea pig)
96886-24-7

(5) Tocris Compounds for VIPR2 Gene

Compound Action Cas Number
[Ala11,22,28]VIP Potent, highly selective VPAC1 agonist 291524-04-4
Bay 55-9837 Potent and selective VPAC2 agonist 463930-25-8
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
VIP (guinea pig) Involved in neurotransmission and smooth muscle relaxation 96886-24-7
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation 40077-57-4
genes like me logo Genes that share compounds with VIPR2: view

Transcripts for VIPR2 Gene

Unigene Clusters for VIPR2 Gene

Vasoactive intestinal peptide receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VIPR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - -
SP2: -
SP3: -
SP4:
SP5: -

Relevant External Links for VIPR2 Gene

GeneLoc Exon Structure for
VIPR2
ECgene alternative splicing isoforms for
VIPR2

Expression for VIPR2 Gene

mRNA expression in normal human tissues for VIPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIPR2 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x4.4).

Protein differential expression in normal tissues from HIPED for VIPR2 Gene

This gene is overexpressed in Plasma (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VIPR2 Gene



SOURCE GeneReport for Unigene cluster for VIPR2 Gene Hs.585052

mRNA Expression by UniProt/SwissProt for VIPR2 Gene

P41587-VIPR2_HUMAN
Tissue specificity: Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78.
genes like me logo Genes that share expression patterns with VIPR2: view

Protein tissue co-expression partners for VIPR2 Gene

Primer Products

Orthologs for VIPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIPR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VIPR2 35
  • 86.31 (n)
  • 87.09 (a)
VIPR2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VIPR2 35
  • 83.72 (n)
  • 85.68 (a)
VIPR2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vipr2 35
  • 82.9 (n)
  • 87.35 (a)
Vipr2 16
Vipr2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VIPR2 35
  • 99.39 (n)
  • 99.54 (a)
VIPR2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vipr2 35
  • 82.36 (n)
  • 87.12 (a)
oppossum
(Monodelphis domestica)
Mammalia VIPR2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VIPR2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves VIPR2 35
  • 70.79 (n)
  • 73.46 (a)
VPAC2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VIPR2 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vipr2 35
  • 65.35 (n)
  • 61.81 (a)
zebrafish
(Danio rerio)
Actinopterygii vipr2 35
  • 62.07 (n)
  • 58.88 (a)
vipr2 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4810 35
Species with no ortholog for VIPR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIPR2 Gene

ENSEMBL:
Gene Tree for VIPR2 (if available)
TreeFam:
Gene Tree for VIPR2 (if available)

Paralogs for VIPR2 Gene

(15) SIMAP similar genes for VIPR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VIPR2: view

Variants for VIPR2 Gene

Sequence variations from dbSNP and Humsavar for VIPR2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1062609 - 159,142,482(-) AATGT(A/G)CAGAG nc-transcript-variant, reference, missense
rs1042620 - 159,030,698(-) CTCCC(A/G)CAACG nc-transcript-variant, downstream-variant-500B, reference, missense
rs885861 -- 159,028,856(-) GCGGT(C/T)GGATC nc-transcript-variant, utr-variant-3-prime
rs885862 -- 159,028,325(-) GCTGT(A/T)TCCTG nc-transcript-variant, utr-variant-3-prime
rs885863 -- 159,028,278(-) GGTCA(A/G)CAGGT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VIPR2 Gene

Variant ID Type Subtype PubMed ID
nsv889647 CNV Gain 21882294
nsv889648 CNV Gain 21882294
nsv519749 CNV Loss 19592680
nsv465262 CNV Gain 19166990
nsv526756 CNV Gain 19592680
nsv889652 CNV Loss 21882294
nsv889653 CNV Loss 21882294
nsv889654 CNV Loss 21882294
dgv7580n71 CNV Loss 21882294
dgv7581n71 CNV Loss 21882294
nsv889657 CNV Gain 21882294
nsv820022 CNV Loss 19587683
esv1258689 CNV Insertion 17803354
esv2621732 CNV Deletion 19546169
esv1955405 CNV Deletion 18987734
esv2080886 CNV Deletion 18987734
esv28310 CNV Loss 19812545
esv2667886 CNV Deletion 23128226
esv1585946 CNV Insertion 17803354
nsv889660 CNV Loss 21882294
nsv831202 CNV Gain 17160897
esv23771 CNV Loss 19812545
esv998866 CNV Deletion 20482838
nsv435963 OTHER Inversion 17901297
esv8515 OTHER Inversion 19470904
nsv889661 CNV Gain+Loss 21882294

Variation tolerance for VIPR2 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VIPR2 Gene

Human Gene Mutation Database (HGMD)
VIPR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIPR2 Gene

Disorders for VIPR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for VIPR2 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia 16
holoprosencephaly-3
  • holoprosencephaly 3
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search VIPR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VIPR2

Genetic Association Database (GAD)
VIPR2
Human Genome Epidemiology (HuGE) Navigator
VIPR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VIPR2
genes like me logo Genes that share disorders with VIPR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VIPR2 Gene

Publications for VIPR2 Gene

  1. Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts. (PMID: 7811244) Svoboda M. … Robberecht P. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 67
  2. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V. … Urretavizcaya M. (Neuropsychopharmacology 2010) 3 23
  3. Identification and characterization of five-transmembrane isoforms of human vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors. (PMID: 16934434) Bokaei P.B. … Branch D.R. (Genomics 2006) 3 23
  4. Structure of the human VIP2R gene for vasoactive intestinal peptide type 2 receptor. (PMID: 10481065) Lutz E.M. … Harmar A.J. (FEBS Lett. 1999) 3 23
  5. Selectivity of effects of vasoactive intestinal peptide on macrophages and lymphocytes in compartmental immune responses. (PMID: 9629281) Goetzl E.J. … Sreedharan S.P. (Ann. N. Y. Acad. Sci. 1998) 3 23

Products for VIPR2 Gene

Sources for VIPR2 Gene

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