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VIPR2 Gene

protein-coding   GIFtS: 66
GCID: GC07M158820

Vasoactive Intestinal Peptide Receptor 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Vasoactive Intestinal Peptide Receptor 21 2     PACAP Type III Receptor2 3
VIP And PACAP Receptor 21 2     C16DUPq36.32
Helodermin-Preferring VIP Receptor2 3     DUP7q36.32
Pituitary Adenylate Cyclase-Activating Polypeptide Type III Receptor2 3     VPAC2R2
PACAP-R-32 3     VPCAP2R2
PACAP-R32 3     Vasoactive Intestinal Polypeptide Receptor 22
VIP-R-22 3     VIP2R3
VPAC22 3     

External Ids:    HGNC: 126951   Entrez Gene: 74342   Ensembl: ENSG000001060187   OMIM: 6019705   UniProtKB: P415873   
ORGUL members:         

Export aliases for VIPR2 gene to outside databases

Previous GC identifers: GC07M157122 GC07M158123 GC07M158237 GC07M158320 GC07M158513 GC07M152560


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VIPR2 Gene:
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal
peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung
and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine
nucleotide binding protein which activates adenylate cyclase. (provided by RefSeq, Aug 2011)

GeneCards Summary for VIPR2 Gene:
VIPR2 (vasoactive intestinal peptide receptor 2) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587
Function: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G
proteins which activate adenylyl cyclase. Can be coupled to phospholipase C

summary for VIPR2 Gene:
Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently
divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous
system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart
and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival,
regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine
release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes
encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIPR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VIPR2 gene promoter:
         c-Fos   AP-1   ATF-2   NRSF form 1   NRSF form 2   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VIPR2 promoter sequence
   Search Chromatin IP Primers for VIPR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VIPR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.3   Ensembl cytogenetic band:  7q36.3   HGNC cytogenetic band: 7q36.3

VIPR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIPR2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M158820:  view genomic region     (about GC identifiers)

Start:
158,820,866 bp from pter      End:
158,937,649 bp from pter
Size:
116,784 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 158,024,240-158,139,944     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587 (See protein sequence)
Recommended Name: Vasoactive intestinal polypeptide receptor 2 precursor  
Size: 438 amino acids; 49479 Da
1 PDB 3D structure from and Proteopedia for VIPR2:
2X57 (3D)    
Secondary accessions: Q13053 Q15870 Q53Y09 Q9UCW0

Explore the universe of human proteins at neXtProt for VIPR2: NX_P41587

Explore proteomics data for VIPR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn58, Asn88, Asn92
  • Modification sites at PhosphoSitePlus

  • See VIPR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003373.2  
    ENSEMBL proteins: 
     ENSP00000262178   ENSP00000366860   ENSP00000384497   ENSP00000402690  
    Reactome Protein details: P41587

    VIPR2 Human Recombinant Protein Products:

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    antibodies-online proteins for VIPR2 (4 products) 

     
    antibodies-online peptides for VIPR2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VIPPACR: GPCR / Class B : VIP and PACAP (ADCYAP1) receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: VPAC2 receptor
    VIP and PACAP receptors

    Selected InterPro protein domains (see all 6):
     IPR002284 GPCR_2_VIP_rcpt_2
     IPR001879 GPCR_2_extracellular_dom
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry P41587

    ProtoNet protein and cluster: P41587

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001571 Vasoactive intestinal peptide receptor signature
    IPB002284 Vasoactive intestinal peptide receptor 2 signature


    UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Find genes that share domains with VIPR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VIPR2_HUMAN, P41587
    Function: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G
    proteins which activate adenylyl cyclase. Can be coupled to phospholipase C

         Genatlas biochemistry entry for VIPR2:
    vasoactive intestinal peptide,also responding to the pituitary adenylate cyclase activating polypeptide in
    stimulating cAMP production,receptor 2,G protein coupled,secretin receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity TAS7811244
    GO:0004999vasoactive intestinal polypeptide receptor activity IEA--
         
    Find genes that share ontologies with VIPR2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for VIPR2:
     Increased gamma-H2AX phosphory  Metaphase cells 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Vipr2):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  reproductive system 

    Find genes that share phenotypes with VIPR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for VIPR2: Vipr2tm1Hmh Vipr2tm1Ajh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VIPR2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VIPR2
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    Addgene plasmids for VIPR2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VIPR2_HUMAN, P41587: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7811244
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with VIPR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VIPR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    3SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    4GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like
    5G alpha (s) signalling events
    G alpha (s) signalling events


    Find genes that share SuperPaths with VIPR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for VIPR2
        SIDS Susceptibility Pathways
    GPCRs, Class B Secretin-like


    1 Reactome Pathway for VIPR2
        G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for VIPR2):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including VIPR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VIPR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VIPR2 (P415873 ENSP000002621784) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    VIPP012823, ENSP000003562134I2D: score=1 STRING: ENSP00000356213
    ADCYAP1P185093I2D: score=1 
    ERBB2IPQ96RT13I2D: score=1 
    ADCY1ENSP000002973234STRING: ENSP00000297323
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS7811244
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007190activation of adenylate cyclase activity IEA--
    GO:0007267cell-cell signaling TAS8757618

    Find genes that share ontologies with VIPR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for VIPR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist[102805-45-8]
    Bay 55-9837Potent and selective VPAC2 agonist[463930-25-8]
    VIP (6-28) (human, rat, porcine, bovine) VIP antagonist[69698-54-0]
    VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission, smooth muscle relaxation [40077-57-4]
    [Ala11,22,28]VIP Potent, highly selective VPAC1 agonist [291524-04-4]

    Selected IUPHAR Ligands for VIPR2 (VPAC2 receptor) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    PACAP-38
    AgonistAgonist9.316930633
    [125I]VIP
    AgonistAgonist9.210801840
    [125I]BAY 55-9837
    AgonistAgonist9.211978642
    N-stearyl-[Nle17]VIP
    AgonistAgonist99726637
    PG 99-465
    AntagonistAntagonist8.711068102
    helodermin
    AgonistAgonist8.59928018
    Ro 25-1392
    AgonistAgonist8.59152366
    Ro 25-1553
    AgonistAgonist8.310570056
    PHV
    AgonistAgonist89928018
    VIP
    AgonistAgonist7.89152366

    2 Novoseek inferred chemical compound relationships for VIPR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 58.4 7 1649637 (2), 1656036 (1), 9350848 (1), 8790782 (1)
    calcium 0 1 9152366 (1)



    Find genes that share compounds with VIPR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VIPR2 gene: 
    NM_003382.4  

    Unigene Cluster for VIPR2:

    Vasoactive intestinal peptide receptor 2
    Hs.585052  [show with all ESTs]
    Unigene Representative Sequence: X95097
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262178(uc003woh.3 uc010lqx.3 uc010lqy.3) ENST00000377633
    ENST00000402066 ENST00000421760
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    Additional mRNA sequence: 

    AK131406.1 AK308955.1 AK310386.1 BC010569.1 BT007118.1 L36566.1 X95097.2 

    6 DOTS entries:

    DT.100177  DT.40106247  DT.102828470  DT.95372523  DT.75104927  DT.92418850 

    Selected AceView cDNA sequences (see all 82):

    BQ186243 AW451336 BT007118 BE048208 AI569243 CR610555 AI871037 AI497953 
    BC010569 AI083865 AK125809 H20255 AI832105 BM692346 T16366 CA449700 
    AI936996 BF527627 AI939543 AL556222 AI884811 BF527866 BG913052 AA723376 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VIPR2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:              -           -                 -                                                           -                     
    SP2:                                                                                                        -                     
    SP3:                          -                                                                                                   
    SP4:                                                                                                                              
    SP5:              -                                                                                                               


    ECgene alternative splicing isoforms for VIPR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VIPR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCACTGTT
    VIPR2 Expression
    About this image


    VIPR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Liver Bud
    VIPR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VIPR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585052

    UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587
    Tissue specificity: Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat,
    Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78

        Pathway & Disease-focused RT2 Profiler PCR Array including VIPR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat VIPR2
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for VIPR2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vipr21 , 5 vasoactive intestinal peptide receptor 21, 5 82.9(n)1
    87.35(a)1
      12 (62.59 cM)5
    223551  NM_009511.21  NP_033537.11 
     1160777265 
    chicken
    (Gallus gallus)
    Aves VIPR21 vasoactive intestinal peptide receptor 2 70.79(n)
    73.46(a)
      420453  NM_001014970.1  NP_001014970.1 
    lizard
    (Anolis carolinensis)
    Reptilia VIPR26
    vasoactive intestinal peptide receptor 2
    67(a)
    1 ↔ 1
    6(7384754-7436487)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia vipr21 vasoactive intestinal peptide receptor 2 65.35(n)
    61.81(a)
      100145780  NM_001127144.1  NP_001120616.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vipr21 vasoactive intestinal peptide receptor 2 62.07(n)
    58.88(a)
      81886  NM_131779.1  NP_571854.1 


    ENSEMBL Gene Tree for VIPR2 (if available)
    TreeFam Gene Tree for VIPR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VIPR2 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  
    PTH2R2  CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  GIPR2  
    15 SIMAP similar genes for VIPR2 using alignment to 4 protein entries:     VIPR2_HUMAN (see all proteins):
    LOC389604    VIP2R    SCTR    VIPR1    ADCYAP1R1    GHRHR
    PTH1R    GIPR    GLP2R    GLP1R    PTHR2    PTH2R
    CRHR2    GCGR    CALCR

    Find genes that share paralogs with VIPR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VIPR2 (see all 3117)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386018711,2
    C--158820387(+) ATACA-/TTGTGG 1 -- int10--------
    rs58887791,2
    C--158820435(+) CACACG/-CCCCA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1134698951,2
    C--158820435(+) CACACG/CCCCCA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs10170341,2
    C,F,A--158820460(-) GCACAT/CGCGTG 1 -- int18Minor allele frequency- C:0.30NA WA EA 368
    rs1457426771,2
    C--158820519(+) CTATT-/AACAGGTT 1 -- int10--------
    rs23018981,2
    C,F,A--158820553(-) ACACGG/CCCTCT 1 -- int111Minor allele frequency- C:0.38EA NA WA 2144
    rs23018971,2
    C,F--158820635(-) GCCTCC/TGTCTG 1 -- int13Minor allele frequency- T:0.23EA WA 1734
    rs1909464041,2
    C--158820686(+) TCAGGG/TAGAGG 1 -- int10--------
    rs754353421,2
    C,F--158820758(+) CTCCCC/TGTCCA 1 -- int12Minor allele frequency- T:0.04NA EA 240
    rs1497453551,2
    --158820884(+) TCAGGC/TTTTAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VIPR2 (158820866 - 158937649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for VIPR2 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2080886CNV Deletion18987734
    esv998866CNV Deletion20482838
    esv1955405CNV Deletion18987734
    esv2621732CNV Deletion19546169
    esv2667886CNV Deletion23128226
    esv1258689CNV Insertion17803354
    esv1585946CNV Insertion17803354
    nsv889654CNV Loss21882294
    nsv889653CNV Loss21882294
    esv28310CNV Loss19812545

    Human Gene Mutation Database (HGMD): VIPR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VIPR2
    DNA2.0 Custom Variant and Variant Library Synthesis for VIPR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601970    OMIM disorders: --


    Find genes that share disorders with VIPR2           About GenesLikeMe

    Genetic Association Database (GAD): VIPR2
    Human Genome Epidemiology (HuGE) Navigator: VIPR2 (9 documents)

    Export disorders for VIPR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VIPR2 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with VIPR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts. (PubMed id 7811244)1, 2, 3 Svoboda M.... Robberecht P. (Biochem. Biophys. Res. Commun. 1994)
    2. Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype. (PubMed id 8938447)1, 2, 9 Mackay M.... Harmar A.J. (Genomics 1996)
    3. Structure of the human VIP2R gene for vasoactive intestinal peptide type 2 receptor. (PubMed id 10481065)1, 2, 9 Lutz E.M.... Harmar A.J. (FEBS Lett. 1999)
    4. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4, 9 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
    5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    6. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (PubMed id 20554694)1, 4 Kovanen L....Partonen T. (Alcohol Alcohol. 2010)
    7. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    8. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. (PubMed id 19470168)1, 4 Englund A....Partonen T. (J Circadian Rhythms 2009)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7434 HGNC: 12695 AceView: VIPR2 Ensembl:ENSG00000106018 euGenes: HUgn7434
    ECgene: VIPR2 Kegg: 7434 H-InvDB: VIPR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VIPR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VIPR2 gene:
    Search GeneIP for patents involving VIPR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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