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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VIPR2 Gene

protein-coding   GIFtS: 62
GCID: GC07M158820

vasoactive intestinal peptide receptor 2
 Explore 22 diseases affiliated with
VIPR2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for VIPR2    

Aliases
for VIPR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Vasoactive Intestinal Peptide Receptor 21 2     PACAP Type III Receptor2 3
VPAC21 2 3     C16DUPq36.32
VPAC2R1 2     DUP7q36.32
Helodermin-Preferring VIP Receptor2 3     VPCAP2R2
Pituitary Adenylate Cyclase-Activating Polypeptide Type III Receptor2 3     Vasoactive Intestinal Polypeptide Receptor 22
PACAP-R-32 3     VIP And PACAP Receptor 22
PACAP-R32 3     VIP2R3
VIP-R-22 3     

External Ids:    HGNC: 126951   Entrez Gene: 74342   Ensembl: ENSG000001060187   OMIM: 6019705   UniProtKB: P415873   

Export aliases for VIPR2 gene to outside databases

Previous GC identifers: GC07M157122 GC07M158123 GC07M158237 GC07M158320 GC07M158513 GC07M152560


Summaries
for VIPR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VIPR2:
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is
involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal
epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding
protein which activates adenylate cyclase. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587
Function: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G
proteins which activate adenylyl cyclase. Can be coupled to phospholipase C

summary for VIPR2:
Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently
divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous
system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart
and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival,
regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine
release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes
encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIPR2


Genomic Views
for VIPR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007741.14  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VIPR2 gene promoter:
         c-Fos   AP-1   ATF-2   NRSF form 1   NRSF form 2   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VIPR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for VIPR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VIPR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.3   Ensembl cytogenetic band:  7q36.3   HGNC cytogenetic band: 7q36.3

VIPR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIPR2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M158820:  view genomic region     (about GC identifiers)

Start:
 158,820,866 bp from pter      End:
 158,937,649 bp from pter
Size:
 116,784 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 158,024,240-158,139,944     

Proteins
for VIPR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587 (See protein sequence)
Recommended Name: Vasoactive intestinal polypeptide receptor 2 precursor  
Size: 438 amino acids; 49479 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for VIPR2:
2X57 (3D)    
Secondary accessions: Q13053 Q15870 Q53Y09 Q9UCW0

Explore the universe of human proteins at neXtProt for VIPR2: NX_P41587

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41587

    • VIPR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003373.2  
    ENSEMBL proteins: 
     ENSP00000262178   ENSP00000366860   ENSP00000384497   ENSP00000400744   ENSP00000402690  
    Reactome Protein details: P41587
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant VIPR2 Protein
    Browse R&D Systems for human recombinant proteins
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    GenScript Custom Purified and Recombinant Proteins Services for VIPR2
    Novus Biologicals VIPR2 Proteins
    Novus Biologicals VIPR2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for VIPR2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7811244
    GO:0016020membrane ----
    GO:0016021integral to membrane ----


    VIPR2 for ontologies           About GeneDecksing



    VIPR2 Antibody Products: 
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    R&D Systems Antibodies for VIPR2 (VIP R2)
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    Novus Biologicals VIPR2 Antibodies
    Search for Antibodies for VIPR2 at Abcam  
    Uscn Antibodies for VIPR2
    ThermoFisher Antibody for VIPR2

    Assay Products for VIPR2: 
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    Uscn ELISAs and CLIAs for VIPR2

    Protein Domains /
    Families
    for VIPR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VIPR2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017983 GPCR_2_secretin-like_CS
     IPR002284 GPCR_2_VIP_rcpt_2
     IPR001879 GPCR_2_extracellular_dom
     IPR017981 GPCR_2-like
     IPR000832 GPCR_2_secretin-like

    Graphical View of Domain Structure for InterPro Entry P41587

    ProtoNet protein and cluster: P41587

    3 Blocks protein families:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001571 Vasoactive intestinal peptide receptor signature
    IPB002284 Vasoactive intestinal peptide receptor 2 signature


    UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Function
    for VIPR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587
    Function: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G
    proteins which activate adenylyl cyclase. Can be coupled to phospholipase C

         Genatlas biochemistry entry for VIPR2:
    vasoactive intestinal peptide,also responding to the pituitary adenylate cyclase activating polypeptide in stimulating
    cAMP production,receptor 2,G protein coupled,secretin receptor superfamily

    miRNA
    Products:            		 OriGene 3'-UTR Clone: VIPR2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIPR2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate VIPR2:
    hsa-miR-466 hsa-miR-3941
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VIPR2 (see all 7)
    OriGene shRNA RFP: VIPR2
    OriGene siRNA: VIPR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIPR2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for VIPR2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VIPR2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VIPR2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: VIPR2 (NM_003382)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIPR2 

    Cell Line
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    Search LifeMap BioReagents cell lines for VIPR2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIPR2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS7811244
    GO:0004999vasoactive intestinal polypeptide receptor activity IEA--


    VIPR2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for VIPR2:
     Increased gamma-H2AX phosphory  Metaphase cells 

    Animal Models:
         Mouse knock-outs for VIPR2: Vipr2tm1Hmh Vipr2tm1Ajh
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Vipr2):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     immune system  reproductive system 

    VIPR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VIPR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00
    3GPCRs, Class B Secretin-like
    		GPCRs, Class B Secretin-like1.00
    4Class A/1 (Rhodopsin-like receptors)
    		Neuroactive ligand-receptor interaction0.38
    5G beta:gamma signalling through PLC beta
    		G alpha (s) signalling events0.14

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for VIPR2 
        SIDS Susceptibility Pathways
    GPCRs, Class B Secretin-like

    4        Reactome Pathways for VIPR2
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (s) signalling events


    1         Kegg Pathway  (Kegg details for VIPR2):
        Neuroactive ligand-receptor interaction


    VIPR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VIPR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for VIPR2 (P415873 ENSP000002621784) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    VIPP012823, ENSP000003562134I2D: score=1 STRING: ENSP00000356213
    ADCYAP1P185093I2D: score=1 
    ERBB2IPQ96RT13I2D: score=1 
    ADCY1ENSP000002973234STRING: ENSP00000297323
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS7811244
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007190activation of adenylate cyclase activity IEA--
    GO:0007267cell-cell signaling TAS8757618
    GO:0048662negative regulation of smooth muscle cell proliferation IEA--


    VIPR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for VIPR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VIPR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for VIPR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist[102805-45-8]
    Bay 55-9837Potent and selective VPAC2 agonist[463930-25-8]
    [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) VIP antagonist--
    VIP (6-28) (human, rat, porcine, bovine) VIP antagonist[69698-54-0]
    VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission, smooth muscle relaxation [40077-57-4]
    2 Novoseek chemical compound relationships for VIPR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 58.4 7 1649637 (2), 1656036 (1), 9350848 (1), 8790782 (1)
    calcium 0 1 9152366 (1)

    Search CenterWatch for drugs/clinical trials and news about VIPR2 

    Transcripts
    for VIPR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for VIPR2 gene: 
    NM_003382.4  

    Unigene Cluster for VIPR2:

    Vasoactive intestinal peptide receptor 2
    Hs.585052  [show with all ESTs]
    Unigene Representative Sequence: X95097
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262178(uc003woh.3 uc010lqx.3 uc010lqy.3) ENST00000377633
    ENST00000402066 ENST00000418475 ENST00000421760

    miRNA
    Products:             		 OriGene 3'-UTR Clone: VIPR2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIPR2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate VIPR2:
    hsa-miR-466 hsa-miR-3941
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VIPR2 (see all 7)
    OriGene shRNA RFP: VIPR2
    OriGene siRNA: VIPR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIPR2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VIPR2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VIPR2
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    GenScript: all cDNA clones in your preferred vector: VIPR2 (NM_003382)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIPR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIPR2 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIPR2

    Additional cDNA sequence: 

    AK131406.1 AK308955.1 AK310386.1 BC010569.1 BT007118.1 L36566.1 X95097.2 

    6 DOTS entries:

    DT.100177  DT.40106247  DT.102828470  DT.95372523  DT.75104927  DT.92418850 

    24/82 AceView cDNA sequences (see all 82):

    AI497953 BE048208 BC010569 AI871037 AI569243 AW451336 BT007118 CR610555 
    BQ186243 NM_003382 BI755294 L36566 BF205022 AA723376 T16366 BX389919 
    BV188367 H20257 AK125809 BC024307 BG913052 BX389920 X95097 H20255 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VIPR2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:              -           -                 -                                                           -                     
    SP2:                                                                                                        -                     
    SP3:                          -                                                                                                   
    SP4:                                                                                                                              
    SP5:              -                                                                                                               


    ECgene alternative splicing isoforms for VIPR2

    Expression
    for VIPR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VIPR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCCACTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    VIPR2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See VIPR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VIPR2

    SOURCE GeneReport for Unigene cluster: Hs.585052

    UniProtKB/Swiss-Prot: VIPR2_HUMAN, P41587
    Tissue specificity: Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer,
    MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78

        SABiosciences Expression via Pathway-Focused PCR Array including VIPR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIPR2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIPR2

    Orthologs
    for VIPR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for VIPR2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves VIPR21 vasoactive intestinal peptide receptor 2 71.22(n)
    74.35(a)    		   420453  NM_001014970.1  NP_001014970.1 
    lizard
    (Anolis carolinensis)    		 Reptilia VIPR26
    		 --
    		 67(a)
    		 1 ↔ 1
    		 6(7384754-7421816)
    zebrafish
    (Danio rerio)    		 Actinopterygii vipr21 vasoactive intestinal peptide receptor 2 62.06(n)
    59.02(a)    		   81886  NM_131779.1  NP_571854.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    (see all 4)    		 --
    		 3(a)
    26(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 Group9.2(517685-519657)
    Group9.2(531165-533904)


    ENSEMBL Gene Tree for VIPR2 (if available)
    TreeFam Gene Tree for VIPR2 (if available) 

    Paralogs
    for VIPR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VIPR2 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  CRHR22  PTH1R2  VIPR12  CRHR12  
    PTH2R2  CALCRL2  ADCYAP1R12  SCTR2  GLP2R2  GIPR2  
    15 SIMAP similar genes for VIPR2 using alignment to 5 protein entries:     VIPR2_HUMAN (see all proteins):
    LOC389604    VIP2R    SCTR    VIPR1    ADCYAP1R1    GHRHR
    PTH1R    GIPR    GLP2R    GLP1R    PTHR2    PTH2R
    CRHR2    GCGR    CALCR

    VIPR2 for paralogs           About GeneDecksing



    Genomic Variants
    for VIPR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2605 NCBI SNPs in VIPR2 are shown (see all 2605)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1386018711,2
    		--158820387(+) ATACA-/TTGTGG 1 -- int10--------
    rs58887791,2
    		C,--158820435(+) CACACG/-CCCCA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs10170341,2
    		C,F,A,--158820460(-) GCACAT/CGCGTG 1 -- int18Minor allele frequency- C:0.30NA WA EA 368
    rs1457426771,2
    		C,--158820519(+) CTATT-/AACAGGTT 1 -- int10--------
    rs23018981,2
    		C,F,A,--158820553(-) ACACGG/CCCTCT 1 -- int111Minor allele frequency- C:0.38EA NA WA 2144
    rs23018971,2
    		C,F,--158820635(-) GCCTCC/TGTCTG 1 -- int13Minor allele frequency- T:0.23EA WA 1734
    rs1909464041,2
    		--158820686(+) TCAGGG/TAGAGG 1 -- int10--------
    rs754353421,2
    		F,--158820758(+) CTCCCC/TGTCCA 1 -- int12Minor allele frequency- T:0.04NA EA 240
    rs1497453551,2
    		--158820884(+) TCAGGC/TTTTAT 1 -- ut310--------
    rs1452178601,2
    		--158820914(+) ATTCCC/TGCCAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VIPR2 (158820866 - 158937649 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 23 variations for VIPR2
         7 CNVs: 70138 95076 82351 34452 95078 100217 95075
         14 Indels: 70139 47310 41054 70137 82353 95074 95077 82352 59396 95073 82354 82350 47309 34379
         2 Inversions: 29464 59847
    Human Gene Mutation Database (HGMD): VIPR2

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    Disorders / Diseases
    for VIPR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VIPR2 for disorders           About GeneDecksing

    OMIM gene information: 601970    OMIM disorders: --

    20/22 diseases for VIPR2 (see all 22):    About MalaCards
    primitive neuroectodermal tumor    neuroectodermal tumors    allergic rhinitis    mood disorder
    neuronitis    holoprosencephaly    rhinitis    bipolar disorder
    multiple sclerosis    myopia    neurofibromatosis    copd
    medulloblastoma    lung cancer    prostate cancer    breast cancer
    sarcoma    neuroblastoma    prostatitis    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: VIPR2 (9 documents)

    Export disorders for VIPR2 gene to outside databases

    Publications
    for VIPR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VIPR2 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with VIPR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts. (PubMed id 7811244)1, 2, 3 Svoboda M.... Robberecht P. (1994)
    2. Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype. (PubMed id 8938447)1, 2, 9 Mackay M.... Harmar A.J. (1996)
    3. Structure of the human VIP2R gene for vasoactive intestinal peptide type 2 receptor. (PubMed id 10481065)1, 2, 9 Lutz E.M.... Harmar A.J. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    6. Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology. (PubMed id 8933357)1, 2 Wei Y. and Mojsov S. (1996)
    7. Selectivity of effects of vasoactive intestinal peptide on macrophages and lymphocytes in compartmental immune responses. (PubMed id 9629281)1, 9 Goetzl E.J....Sreedharan S.P. (1998)
    8. Transduction of specific inhibition of HuT 78 human T cell chemotaxis by type I vasoactive intestinal peptide receptors. (PubMed id 8757618)1, 9 Xia M....Goetzl E.J. (1996)
    9. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CL OCK and VIP with bipolar disorder. (PubMed id 20072116)1, 9 Soria V....Urretavizcaya M. (2010)
    10. Identification and characterization of five-transmembrane isoforms of human vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors. (PubMed id 16934434)1, 9 Bokaei P.B....Branch D.R. (2006)

    External Searches for VIPR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing VIPR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7434 HGNC: 12695 AceView: VIPR2 Ensembl:ENSG00000106018 euGenes: HUgn7434
    ECgene: VIPR2 Kegg: 7434 H-InvDB: VIPR2

    Other Databases showing VIPR2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VIPR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VIPR2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for VIPR2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for VIPR2 gene:
    Search GeneIP for patents involving VIPR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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