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Aliases for VIPR2 Gene

Aliases for VIPR2 Gene

  • Vasoactive Intestinal Peptide Receptor 2 2 3
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type III Receptor 3 4
  • Helodermin-Preferring VIP Receptor 3 4
  • VIP And PACAP Receptor 2 2 3
  • PACAP Type III Receptor 3 4
  • PACAP-R-3 3 4
  • PACAP-R3 3 4
  • VIP-R-2 3 4
  • VPAC2 3 4
  • Vasoactive Intestinal Polypeptide Receptor 2 3
  • C16DUPq36.3 3
  • DUP7q36.3 3
  • VPCAP2R 3
  • VPAC2R 3
  • VIP2R 4

External Ids for VIPR2 Gene

Previous GeneCards Identifiers for VIPR2 Gene

  • GC07M157122
  • GC07M158123
  • GC07M158237
  • GC07M158320
  • GC07M158513
  • GC07M158820
  • GC07M152560

Summaries for VIPR2 Gene

Entrez Gene Summary for VIPR2 Gene

  • This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]

GeneCards Summary for VIPR2 Gene

VIPR2 (Vasoactive Intestinal Peptide Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is GIPR.

UniProtKB/Swiss-Prot for VIPR2 Gene

  • This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

Tocris Summary for VIPR2 Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival, regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIPR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIPR2 Gene

Genomics for VIPR2 Gene

Regulatory Elements for VIPR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VIPR2 Gene

159,028,175 bp from pter
159,144,957 bp from pter
116,783 bases
Minus strand

Genomic View for VIPR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VIPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIPR2 Gene

Proteins for VIPR2 Gene

  • Protein details for VIPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vasoactive intestinal polypeptide receptor 2
    Protein Accession:
    Secondary Accessions:
    • Q13053
    • Q15870
    • Q53Y09
    • Q6ZN22
    • Q9UCW0

    Protein attributes for VIPR2 Gene

    438 amino acids
    Molecular mass:
    49479 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIPR2 Gene

    Alternative splice isoforms for VIPR2 Gene


neXtProt entry for VIPR2 Gene

Proteomics data for VIPR2 Gene at MOPED

Post-translational modifications for VIPR2 Gene

  • Glycosylation at Asn58, Asn88, and Asn92
  • Modification sites at PhosphoSitePlus

Other Protein References for VIPR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for VIPR2 Gene

Domains for VIPR2 Gene

Gene Families for VIPR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family.
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with VIPR2: view

Function for VIPR2 Gene

Molecular function for VIPR2 Gene

GENATLAS Biochemistry:
vasoactive intestinal peptide,also responding to the pituitary adenylate cyclase activating polypeptide in stimulating cAMP production,receptor 2,G protein coupled,secretin receptor superfamily
UniProtKB/Swiss-Prot Function:
This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

Gene Ontology (GO) - Molecular Function for VIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity TAS 7811244
GO:0004999 vasoactive intestinal polypeptide receptor activity IEA --
genes like me logo Genes that share ontologies with VIPR2: view
genes like me logo Genes that share phenotypes with VIPR2: view

Animal Models for VIPR2 Gene

MGI Knock Outs for VIPR2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VIPR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for VIPR2 Gene

Localization for VIPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIPR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for VIPR2 Gene COMPARTMENTS Subcellular localization image for VIPR2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for VIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7811244
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with VIPR2: view

Pathways for VIPR2 Gene

genes like me logo Genes that share pathways with VIPR2: view

Pathways by source for VIPR2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7811244
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007190 activation of adenylate cyclase activity IEA --
GO:0007267 cell-cell signaling TAS 8757618
genes like me logo Genes that share ontologies with VIPR2: view

Drugs for VIPR2 Gene

(5) Tocris Compounds for VIPR2 Gene

Compound Action Cas Number
[Ala11,22,28]VIP Potent, highly selective VPAC1 agonist [291524-04-4]
[D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist [102805-45-8]
Bay 55-9837 Potent and selective VPAC2 agonist [463930-25-8]
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP [118025-43-7]
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation [40077-57-4]

(21) IUPHAR Ligand for VIPR2 Gene

Ligand Type Action Affinity Pubmed IDs
maxadilan Agonist Agonist 10.3
PACAP-38 Agonist Agonist 10.3
[125I]BAY 55-9837 Agonist Agonist 9.2
[125I]PACAP-27 Agonist Agonist 9.1
N-stearyl-[Nle17]VIP Agonist Agonist 9
PACAP-27 Agonist Agonist 8.5
helodermin Agonist Agonist 8.5
Ro 25-1392 Agonist Agonist 8.5
PHV Agonist Agonist 8
PHI Agonist Agonist 7.5
N-stearyl-[Nle17] neurotensin-(6-11)/VIP-(7-28) Antagonist Antagonist 7.2
PG 99-465 Agonist Agonist 7.1
VIP Agonist Agonist 6.3
Ro 25-1553 Agonist Agonist 6
[Ala11,22,28]VIP Agonist Agonist 5.8
secretin Agonist Agonist 5.3
BAY 55-9837 Agonist Agonist 5
PG 97-269 Antagonist Antagonist
[Arg16]chicken secretin Agonist Full agonist
[125I]VIP Agonist Full agonist
[Lys15,Arg16,Leu27]VIP-(1?ao7)/GRF-(8?ao27)-NH2 Agonist Full agonist

(2) Novoseek inferred chemical compound relationships for VIPR2 Gene

Compound -log(P) Hits PubMed IDs
adenylate 58.4 5
calcium 0 1
genes like me logo Genes that share compounds with VIPR2: view

Transcripts for VIPR2 Gene

Unigene Clusters for VIPR2 Gene

Vasoactive intestinal peptide receptor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VIPR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VIPR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - -
SP2: -
SP3: -
SP5: -

Relevant External Links for VIPR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VIPR2 Gene

mRNA expression in normal human tissues for VIPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIPR2 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (4.4).

Protein differential expression in normal tissues for VIPR2 Gene

This gene is overexpressed in Plasma (67.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VIPR2 Gene

SOURCE GeneReport for Unigene cluster for VIPR2 Gene Hs.585052

mRNA Expression by UniProt/SwissProt for VIPR2 Gene

Tissue specificity: Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78.
genes like me logo Genes that share expressions with VIPR2: view

Expression partners for VIPR2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for VIPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIPR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VIPR2 35
  • 86.31 (n)
  • 87.09 (a)
VIPR2 36
  • 84 (a)
(Canis familiaris)
Mammalia VIPR2 35
  • 83.72 (n)
  • 85.68 (a)
VIPR2 36
  • 84 (a)
(Mus musculus)
Mammalia Vipr2 35
  • 82.9 (n)
  • 87.35 (a)
Vipr2 16
Vipr2 36
  • 86 (a)
(Pan troglodytes)
Mammalia VIPR2 35
  • 99.39 (n)
  • 99.54 (a)
VIPR2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Vipr2 35
  • 82.36 (n)
  • 87.12 (a)
(Monodelphis domestica)
Mammalia VIPR2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia VIPR2 36
  • 78 (a)
(Gallus gallus)
Aves VIPR2 35
  • 70.79 (n)
  • 73.46 (a)
VPAC2 36
  • 73 (a)
(Anolis carolinensis)
Reptilia VIPR2 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vipr2 35
  • 65.35 (n)
  • 61.81 (a)
(Danio rerio)
Actinopterygii vipr2 35
  • 62.07 (n)
  • 58.88 (a)
vipr2 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4810 35
Species with no ortholog for VIPR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIPR2 Gene

Gene Tree for VIPR2 (if available)
Gene Tree for VIPR2 (if available)

Paralogs for VIPR2 Gene

(15) SIMAP similar genes for VIPR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VIPR2: view

Variants for VIPR2 Gene

Sequence variations from dbSNP and Humsavar for VIPR2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10133 -- 159,031,754(+) GGCTG(C/T)GGCAC intron-variant, missense, reference
rs41558 -- 159,132,237(-) tgccc(A/G)cgcct intron-variant
rs379542 -- 159,145,070(+) TCCTC(A/C)CCGCC upstream-variant-2KB
rs388323 -- 159,146,669(+) ATCCG(G/T)CATAT upstream-variant-2KB
rs388347 -- 159,146,689(+) ACCTG(C/G)CTGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VIPR2 Gene

Variant ID Type Subtype PubMed ID
nsv889647 CNV Gain 21882294
nsv889648 CNV Gain 21882294
nsv519749 CNV Loss 19592680
nsv465262 CNV Gain 19166990
nsv526756 CNV Gain 19592680
nsv889652 CNV Loss 21882294
nsv889653 CNV Loss 21882294
nsv889654 CNV Loss 21882294
dgv7580n71 CNV Loss 21882294
dgv7581n71 CNV Loss 21882294
nsv889657 CNV Gain 21882294
nsv820022 CNV Loss 19587683
esv1258689 CNV Insertion 17803354
esv2621732 CNV Deletion 19546169
esv1955405 CNV Deletion 18987734
esv2080886 CNV Deletion 18987734
esv28310 CNV Loss 19812545
esv2667886 CNV Deletion 23128226
esv1585946 CNV Insertion 17803354
nsv889660 CNV Loss 21882294
nsv831202 CNV Gain 17160897
esv23771 CNV Loss 19812545
esv998866 CNV Deletion 20482838
nsv435963 OTHER Inversion 17901297
esv8515 OTHER Inversion 19470904
nsv889661 CNV Gain+Loss 21882294

Relevant External Links for VIPR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIPR2 Gene

Disorders for VIPR2 Gene

Relevant External Links for VIPR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for VIPR2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for VIPR2 Gene

Publications for VIPR2 Gene

  1. Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype. (PMID: 8938447) Mackay M. … Harmar A.J. (Genomics 1996) 3 4 23
  2. Structure of the human VIP2R gene for vasoactive intestinal peptide type 2 receptor. (PMID: 10481065) Lutz E.M. … Harmar A.J. (FEBS Lett. 1999) 3 4 23
  3. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V. … Urretavizcaya M. (Neuropsychopharmacology 2010) 3 23 48
  4. Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts. (PMID: 7811244) Svoboda M. … Robberecht P. (Biochem. Biophys. Res. Commun. 1994) 2 3 4
  5. Transduction of specific inhibition of HuT 78 human T cell chemotaxis by type I vasoactive intestinal peptide receptors. (PMID: 8757618) Xia M. … Goetzl E.J. (J. Immunol. 1996) 3 23

Products for VIPR2 Gene

  • Addgene plasmids for VIPR2

Sources for VIPR2 Gene

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