Aliases for VIPR1 Gene
- Vasoactive Intestinal Peptide Receptor 1 2 3
- VIP And PACAP Receptor 1 2 3
- PACAP Type II Receptor 3 4
- PACAP-R-2 3 4
- PACAP-R2 3 4
- VIP-R-1 3 4
- VPAC1 3 4
- Pituitary Adenylate Cyclase Activating Polypeptide Receptor, Type II 3
- Pituitary Adenylate Cyclase-Activating Polypeptide Type II Receptor 4
- Vasoactive Intestinal Polypeptide Receptor 1 3
- VIP Receptor, Type I 3
External Ids for VIPR1 Gene
Previous GeneCards Identifiers for VIPR1 Gene
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for VIPR1 Gene
VIPR1 (Vasoactive Intestinal Peptide Receptor 1) is a Protein Coding gene. Diseases associated with VIPR1 include hepatitis c virus. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is VIPR2.
UniProtKB/Swiss-Prot for VIPR1 Gene
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.
Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival, regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.