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Aliases for VIPR1 Gene

Aliases for VIPR1 Gene

  • Vasoactive Intestinal Peptide Receptor 1 2 3
  • VIP And PACAP Receptor 1 2 3
  • PACAP Type II Receptor 3 4
  • PACAP-R-2 3 4
  • PACAP-R2 3 4
  • VIP-R-1 3 4
  • VPAC1 3 4
  • Pituitary Adenylate Cyclase Activating Polypeptide Receptor, Type II 3
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type II Receptor 4
  • Vasoactive Intestinal Polypeptide Receptor 1 3
  • VIP Receptor, Type I 3
  • VPCAP1R 3
  • VPAC1R 3
  • VAPC1 3
  • RDC1 3
  • HVR1 3
  • V1RG 3
  • VIPR 3
  • VIRG 3
  • II 3

External Ids for VIPR1 Gene

Previous GeneCards Identifiers for VIPR1 Gene

  • GC03P041848
  • GC03P041710
  • GC03P042350
  • GC03P042504
  • GC03P042505

Summaries for VIPR1 Gene

Entrez Gene Summary for VIPR1 Gene

  • This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for VIPR1 Gene

VIPR1 (Vasoactive Intestinal Peptide Receptor 1) is a Protein Coding gene. Diseases associated with VIPR1 include hepatitis c virus. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for VIPR1 Gene

  • This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.

Tocris Summary for VIPR1 Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival, regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIPR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIPR1 Gene

Genomics for VIPR1 Gene

Regulatory Elements for VIPR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VIPR1 Gene

42,489,299 bp from pter
42,537,573 bp from pter
48,275 bases
Plus strand

Genomic View for VIPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VIPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIPR1 Gene

Proteins for VIPR1 Gene

  • Protein details for VIPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vasoactive intestinal polypeptide receptor 1
    Protein Accession:
    Secondary Accessions:
    • A5JUT9
    • B3KPV1
    • B4DEB5
    • B4DGI4
    • F5H1F5
    • G3V0I1
    • Q15871
    • Q6P2M6

    Protein attributes for VIPR1 Gene

    457 amino acids
    Molecular mass:
    51547 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIPR1 Gene

    Alternative splice isoforms for VIPR1 Gene


neXtProt entry for VIPR1 Gene

Proteomics data for VIPR1 Gene at MOPED

Post-translational modifications for VIPR1 Gene

  • Glycosylation at Asn58, Asn69, Asn100, and Asn290
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for VIPR1 Gene

Domains for VIPR1 Gene

Gene Families for VIPR1 Gene

  • VIPPACR :GPCR / Class B : VIP and PACAP (ADCYAP1) receptors

Graphical View of Domain Structure for InterPro Entry



  • P32241
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with VIPR1: view

Function for VIPR1 Gene

Molecular function for VIPR1 Gene

GENATLAS Biochemistry:
vasoactive intestinal peptide receptor 1,G protein coupled,secretin receptor superfamily
UniProtKB/Swiss-Prot Function:
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.

Gene Ontology (GO) - Molecular Function for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0004999 vasoactive intestinal polypeptide receptor activity IEA --
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with VIPR1: view
genes like me logo Genes that share phenotypes with VIPR1: view

Animal Models for VIPR1 Gene

MGI Knock Outs for VIPR1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VIPR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for VIPR1 Gene

Localization for VIPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIPR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for VIPR1 Gene COMPARTMENTS Subcellular localization image for VIPR1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8179610
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with VIPR1: view

Pathways for VIPR1 Gene

genes like me logo Genes that share pathways with VIPR1: view

Pathways by source for VIPR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 8390245
GO:0006955 immune response TAS 8390245
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8179610
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8390245
genes like me logo Genes that share ontologies with VIPR1: view

Compounds for VIPR1 Gene

(5) Tocris Compounds for VIPR1 Gene

Compound Action Cas Number
[Ala11,22,28]VIP Potent, highly selective VPAC1 agonist [291524-04-4]
[D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist [102805-45-8]
Bay 55-9837 Potent and selective VPAC2 agonist [463930-25-8]
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP [118025-43-7]
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation [40077-57-4]

(21) IUPHAR Ligand for VIPR1 Gene

Ligand Type Action Affinity Pubmed IDs
PACAP-38 Agonist Agonist 10.3
[125I]PACAP-27 Agonist Agonist 9.1
N-stearyl-[Nle17]VIP Agonist Agonist 9
PACAP-27 Agonist Agonist 8.5
helodermin Agonist Agonist 8.5
Ro 25-1392 Agonist Agonist 8.5
PHV Agonist Agonist 8
PHI Agonist Agonist 7.5
N-stearyl-[Nle17] neurotensin-(6-11)/VIP-(7-28) Antagonist Antagonist 7.2
PG 99-465 Agonist Agonist 7.1
VIP Agonist Agonist 6.3
GHRH Agonist Agonist 6.2
Ro 25-1553 Agonist Agonist 6
[Ala11,22,28]VIP Agonist Agonist 5.8
PHM Agonist Agonist 5.7
secretin Agonist Agonist 5.3
BAY 55-9837 Agonist Agonist 5
[125I]VIP Agonist Full agonist
[Lys15,Arg16,Leu27]VIP-(1?ao7)/GRF-(8?ao27)-NH2 Agonist Full agonist
PG 97-269 Antagonist Antagonist
[Arg16]chicken secretin Agonist Full agonist

(15) Novoseek inferred chemical compound relationships for VIPR1 Gene

Compound -log(P) Hits PubMed IDs
adenylate 77.3 34
aequorin 39 3
ribavirin 25.4 1
cyclic amp 16.9 4
alanine 14.7 4
genes like me logo Genes that share compounds with VIPR1: view

Transcripts for VIPR1 Gene

Unigene Clusters for VIPR1 Gene

Vasoactive intestinal peptide receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VIPR1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VIPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP10: - - - - - - - - -
SP12: -
SP14: -
SP15: -

ExUns: 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP9: -
SP12: -

Relevant External Links for VIPR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VIPR1 Gene

mRNA expression in normal human tissues for VIPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIPR1 Gene

This gene is overexpressed in Lung (10.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VIPR1 Gene

SOURCE GeneReport for Unigene cluster for VIPR1 Gene Hs.348500

mRNA Expression by UniProt/SwissProt for VIPR1 Gene

Tissue specificity: In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT.
genes like me logo Genes that share expressions with VIPR1: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for VIPR1 Gene

Orthologs for VIPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VIPR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VIPR1 35
  • 89.93 (n)
  • 88.62 (a)
VIPR1 36
  • 88 (a)
(Canis familiaris)
Mammalia VIPR1 35
  • 89.25 (n)
  • 87.28 (a)
VIPR1 36
  • 85 (a)
(Mus musculus)
Mammalia Vipr1 35
  • 85.85 (n)
  • 84.68 (a)
Vipr1 16
Vipr1 36
  • 84 (a)
(Pan troglodytes)
Mammalia VIPR1 35
  • 95.44 (n)
  • 94.9 (a)
(Rattus norvegicus)
Mammalia Vipr1 35
  • 84.83 (n)
  • 84.46 (a)
(Monodelphis domestica)
Mammalia VIPR1 36
  • 66 (a)
(Gallus gallus)
Aves VIPR1 35
  • 67.82 (n)
  • 66.74 (a)
VIPR1 36
  • 65 (a)
(Anolis carolinensis)
Reptilia VIPR1 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497291 35
  • 66.83 (n)
  • 66.35 (a)
(Danio rerio)
Actinopterygii vipr1b 35
  • 63.94 (n)
  • 60.34 (a)
vipr1a 36
  • 55 (a)
vipr1b 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 37
  • 29 (a)
Species with no ortholog for VIPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIPR1 Gene

Gene Tree for VIPR1 (if available)
Gene Tree for VIPR1 (if available)

Paralogs for VIPR1 Gene

Selected SIMAP similar genes for VIPR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VIPR1: view

Variants for VIPR1 Gene

Sequence variations from dbSNP and Humsavar for VIPR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs895 -- 42,536,831(+) CTTAG(C/T)TATCA utr-variant-3-prime
rs896 -- 42,536,843(+) CTTTT(C/T)AAAGT utr-variant-3-prime
rs897 -- 42,536,811(+) TACCC(C/T)ATTCT utr-variant-3-prime
rs8913 -- 42,537,276(-) GAGTC(C/T)GTGCT utr-variant-3-prime
rs9677 -- 42,537,370(+) TGAAT(C/T)CCCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VIPR1 Gene

Variant ID Type Subtype PubMed ID
nsv527430 CNV Loss 19592680

Relevant External Links for VIPR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIPR1 Gene

Disorders for VIPR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for VIPR1 Gene in MalaCards »

(1) Diseases for VIPR1 Gene including...

(35) Novoseek inferred disease relationships for VIPR1 Gene

Disease -log(P) Hits PubMed IDs
hepatitis c 82.2 57
hepatitis c chronic 62.8 13
hepatitis chronic 57.4 8
infection chronic 46.2 4
viremia 42.3 5

Relevant External Links for VIPR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with VIPR1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for VIPR1 Gene

Publications for VIPR1 Gene

  1. Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene. (PMID: 7708752) Sreedharan S.P. … Goetzl E.J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 23
  2. A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B*2705 in Sardinia. (PMID: 18668120) Paladini F. … Sorrentino R. (Genes Immun. 2008) 3 23 48
  3. Differential expression of vasoactive intestinal peptide receptor 1 expression in inflammatory bowel disease. (PMID: 17611633) Yukawa T. … Arakawa T. (Int. J. Mol. Med. 2007) 3 23
  4. The neuropeptide pituitary adenylate cyclase activating polypeptide modulates Ca2+ and pro-inflammatory functions in human monocytes through the G protein-coupled receptors VPAC-1 and formyl peptide receptor-like 1. (PMID: 17651798) El Zein N. … Sariban E. (Cell Calcium 2008) 3 23
  5. VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium. (PMID: 16037943) Chignard N. … Housset C. (Hepatology 2005) 3 23

Products for VIPR1 Gene

  • Addgene plasmids for VIPR1

Sources for VIPR1 Gene

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