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VIPR1 Gene

protein-coding   GIFtS: 67
GCID: GC03P042520

Vasoactive Intestinal Peptide Receptor 1

  See VIPR1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Vasoactive Intestinal Peptide Receptor 11 2     V1RG2
VIP And PACAP Receptor 11 2     VAPC12
PACAP-R-22 3     VIPR2
PACAP-R22 3     VIRG2
VIP-R-12 3     VPAC1R2
VPAC12 3     VPCAP1R2
PACAP Type II Receptor2 3     Pituitary Adenylate Cyclase Activating Polypeptide Receptor, Type II2
HVR12     Vasoactive Intestinal Polypeptide Receptor 12
II2     VIP Receptor, Type I2
RDC12     Pituitary Adenylate Cyclase-Activating Polypeptide Type II Receptor3

External Ids:    HGNC: 126941   Entrez Gene: 74332   Ensembl: ENSG000001148127   OMIM: 1923215   UniProtKB: P322413   

Export aliases for VIPR1 gene to outside databases

Previous GC identifers: GC03P041848 GC03P041710 GC03P042350 GC03P042504 GC03P042505


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VIPR1 Gene:
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal
peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung
and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine
nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for VIPR1 Gene:
VIPR1 (vasoactive intestinal peptide receptor 1) is a protein-coding gene. Diseases associated with VIPR1 include idiopathic achalasia. GO annotations related to this gene include vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241
Function: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate
adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38

summary for VIPR1 Gene:
Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently
divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous
system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart
and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival,
regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine
release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes
encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIPR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VIPR1 gene promoter:
         NF-1/L   NF-1   AP-1   Pax-5   SREBP-1c   Nkx2-5   SREBP-1b   GATA-1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVIPR1 promoter sequence
   Search Chromatin IP Primers for VIPR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VIPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22

VIPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIPR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P042520:  view genomic region     (about GC identifiers)

Start:
42,530,791 bp from pter      End:
42,579,065 bp from pter
Size:
48,275 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241 (See protein sequence)
Recommended Name: Vasoactive intestinal polypeptide receptor 1 precursor  
Size: 457 amino acids; 51547 Da
3 PDB 3D structures from and Proteopedia for VIPR1:
1OF2 (3D)        1OGT (3D)        3B3I (3D)    
Secondary accessions: A5JUT9 B3KPV1 B4DEB5 B4DGI4 F5H1F5 G3V0I1 Q15871 Q6P2M6
Alternative splicing: 5 isoforms:  P32241-1   P32241-2   P32241-3   P32241-4   P32241-5   

Explore the universe of human proteins at neXtProt for VIPR1: NX_P32241

Explore proteomics data for VIPR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn58, Asn69, Asn100, Asn290
  • Modification sites at PhosphoSitePlus

  • See VIPR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001238811.1  NP_001238812.1  NP_001238813.1  NP_001238814.1  NP_004615.2  

    ENSEMBL proteins: 
     ENSP00000394950   ENSP00000415013   ENSP00000393215   ENSP00000388479   ENSP00000403680  
     ENSP00000403478   ENSP00000327246   ENSP00000396204   ENSP00000445701   ENSP00000415371  
    Reactome Protein details: P32241

    VIPR1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant VIPR1 Protein
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    Cloud-Clone Corp. Proteins for VIPR1

     
    Search eBioscience for Proteins for VIPR1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VIPPACR: GPCR / Class B : VIP and PACAP (ADCYAP1) receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: VPAC1 receptor
    VIP and PACAP receptors

    Selected InterPro protein domains (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR001771 GPCR_2_VIP_rcpt_1
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry P32241

    ProtoNet protein and cluster: P32241

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001571 Vasoactive intestinal peptide receptor signature
    IPB001771 Vasoactive intestinal peptide receptor 1 signature


    UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Find genes that share domains with VIPR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VIPR1_HUMAN, P32241
    Function: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate
    adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38

         Genatlas biochemistry entry for VIPR1:
    vasoactive intestinal peptide receptor 1,G protein coupled,secretin receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0004999vasoactive intestinal polypeptide receptor activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with VIPR1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for VIPR1:
     Increased cell number in G1, s  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vipr1):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with VIPR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vipr1tm1Msod for VIPR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VIPR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VIPR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VIPR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VIPR1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat VIPR1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate VIPR1:
    hsa-miR-615-3p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidVIPR1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat VIPR1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: VIPR1 (NM_004624)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIPR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIPR1

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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VIPR1_HUMAN, P32241: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8179610
    GO:0016020membrane ----

    Find genes that share ontologies with VIPR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VIPR1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    3SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    4Selected targets of GCR alpha
    Selected targets of GCR alpha
    5GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like


    Find genes that share SuperPaths with VIPR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for VIPR1
        Transendothelial Migration of Leukocytes

    3 BioSystems Pathways for VIPR1
        SIDS Susceptibility Pathways
    GPCRs, Class B Secretin-like
    Glucocorticoid receptor regulatory network

    1 Reactome Pathway for VIPR1
        G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for VIPR1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including VIPR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VIPR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for VIPR1 (P322411, 2, 3 ENSP000003272464) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51637 I2D: score=3 
    CALM3P621582, 3MINT-51637 I2D: score=3 
    ENSG00000224608P039892, 3MINT-8144492 I2D: score=1 
    HLA-BP039892, 3MINT-8144492 I2D: score=1 
    CALM1P621582, 3, ENSP000003494674MINT-51637 I2D: score=3 STRING: ENSP00000349467
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS8390245
    GO:0006955immune response TAS8390245
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS8179610
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8390245

    Find genes that share ontologies with VIPR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for VIPR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist[102805-45-8]
    Bay 55-9837Potent and selective VPAC2 agonist[463930-25-8]
    VIP (6-28) (human, rat, porcine, bovine) VIP antagonist[69698-54-0]
    VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission, smooth muscle relaxation [40077-57-4]
    [Ala11,22,28]VIP Potent, highly selective VPAC1 agonist [291524-04-4]

    Selected IUPHAR Ligands for VIPR1 (VPAC1 receptor) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]VIP
    AgonistAgonist9.410801840
    VIP
    AgonistAgonist9.18390245
    [Lys15,Arg16,Leu27]VIP-(1?ao7)/GRF-(8?ao27)-NH2
    AgonistAgonist99437714
    PG 97-269
    AntagonistAntagonist8.710570056
    PACAP-27
    AgonistAgonist8.59928018
    N-stearyl-[Nle17]VIP
    AgonistAgonist8.39726637
    PACAP-38
    AgonistAgonist8.28791009
    [Ala11,22,28]VIP
    AgonistAgonist7.616930633
    N-stearyl-[Nle17] neurotensin-(6-11)/VIP-(7-28)
    AntagonistAntagonist7.511931347
    [Arg16]chicken secretin
    AgonistAgonist7.29437714

    Selected Novoseek inferred chemical compound relationships for VIPR1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 77.3 37 16019382 (2), 10769164 (2), 9920725 (2), 10698193 (1) (see all 31)
    aequorin 39 3 11587546 (1), 12196112 (1), 11981043 (1)
    ribavirin 25.4 1 16038475 (1)
    cyclic amp 16.9 4 11587546 (1), 10933794 (1), 11398176 (1), 9152366 (1)
    alanine 14.7 4 11851900 (1), 9620342 (1), 8314302 (1), 9443106 (1)
    forskolin 13.7 2 11027674 (1), 11138925 (1)
    glucose 4.05 3 11978642 (1), 12525492 (1)
    lipid 1.75 1 17393515 (1)
    gtp 0 1 15589042 (1)
    nitric oxide 0 1 11193883 (1)



    Find genes that share compounds with VIPR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VIPR1 gene (5 alternative transcripts): 
    NM_001251882.1  NM_001251883.1  NM_001251884.1  NM_001251885.1  NM_004624.3  

    Unigene Cluster for VIPR1:

    Vasoactive intestinal peptide receptor 1
    Hs.348500  [show with all ESTs]
    Unigene Representative Sequence: AK126759
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433647(uc021wwl.1) ENST00000473495 ENST00000490161 ENST00000487545
    ENST00000450274 ENST00000436487 ENST00000443646 ENST00000439910 ENST00000439731
    ENST00000325123(uc003clf.2 uc011azn.2 uc011azl.1 uc011azm.1 uc003clg.2)
    ENST00000446673 ENST00000473575 ENST00000495189 ENST00000465338 ENST00000498102
    ENST00000543411 ENST00000438259
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    2 qRT-PCR Assays for microRNAs that regulate VIPR1:
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VIPR1
      QuantiTect SYBR Green Assays in human, mouse, rat VIPR1
      QuantiFast Probe-based Assays in human, mouse, rat VIPR1

    Additional mRNA sequence: 

    AK056819.1 AK123943.1 AK126759.1 AK293548.1 AK294609.1 AK298115.1 AK314334.1 BC064424.1 
    EF577396.1 L13288.1 L20295.1 X75299.1 

    8 DOTS entries:

    DT.101981721  DT.87016636  DT.95278328  DT.100039235  DT.97834355  DT.95130428  DT.120861608  DT.100029880 

    Selected AceView cDNA sequences (see all 119):

    R72302 R46758 H45098 R73300 BM742129 R46451 BQ686892 R72351 
    BI910800 H45409 BI820314 BQ689146 BM985121 W32571 CB305819 BI820237 
    T16182 BU734904 BC064424 AK056819 BG257293 L20295 BI755897 AI668793 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VIPR1 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^
    SP1:                    -     -     -     -     -     -     -     -                                               -                 -                           
    SP2:                                                                    -                                         -                 -                           
    SP3:                                                                    -                                         -                 -                           
    SP4:                                                                    -     -                                   -                 -     -     -     -         
    SP5:                                                                    -     -                                   -                 -                           

    ExUns: 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:  -                             -     -                           
    SP2:  -                             -     -                           
    SP3:                                -     -                           
    SP4:  -                                                               
    SP5:                                                                  


    ECgene alternative splicing isoforms for VIPR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VIPR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCATCTGG
    VIPR1 Expression
    About this image


    VIPR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SM30 cells
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced SM30 cells
     
     Lung (Respiratory System)
    VIPR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VIPR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348500

    UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241
    Tissue specificity: In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart,
    kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78,
    Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT

        Pathway & Disease-focused RT2 Profiler PCR Array including VIPR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for VIPR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vipr11 , 5 vasoactive intestinal peptide receptor 11, 5 85.85(n)1
    84.68(a)1
      9 (72.50 cM)5
    223541  NM_011703.41  NP_035833.21 
     1216427165 
    chicken
    (Gallus gallus)
    Aves VIPR11 vasoactive intestinal peptide receptor 1 67.82(n)
    66.74(a)
      395329  NM_001097523.1  NP_001090992.1 
    lizard
    (Anolis carolinensis)
    Reptilia VIPR16
    vasoactive intestinal peptide receptor 1
    60(a)
    1 ↔ 1
    6(2460335-2567982)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004972911 vasoactive intestinal polypeptide receptor-like 66.83(n)
    66.35(a)
      100497291  XM_002941864.2  XP_002941910.2 
    zebrafish
    (Danio rerio)
    Actinopterygii vipr1b1 vasoactive intestinal peptide receptor 1b 63.94(n)
    60.34(a)
      503868  NM_001013353.1  NP_001013371.1 


    ENSEMBL Gene Tree for VIPR1 (if available)
    TreeFam Gene Tree for VIPR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VIPR1 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  CRHR12  PTH2R2  
    CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    15 SIMAP similar genes for VIPR1 using alignment to 4 protein entries:     VIPR1_HUMAN (see all proteins):
    SCTR    VIPR2    GHRHR    GLP2R    ADCYAP1R1    CALCRL
    CRHR2    GCGR    GIPR    CALCR    GLP1R    PTH1R
    PTH2R    PTHR2    CRHR1

    Find genes that share paralogs with VIPR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VIPR1 (see all 1072)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006213121,2
    Cuntested142505745(+) TGAGCG/AGAAGT 10 /Q /R /G mis11Minor allele frequency- A:0.00EU 1323
    rs1449508321,2
    Cuntested142505759(+) TCTGGG/AGGTAC 10 /R /G mis1 syn11Minor allele frequency- A:0.00NA 4550
    rs574989401,2
    C,F--42462166(+) TTCTTC/TCCCTT 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs786253931,2
    C,F--42462180(+) CTCTCT/CTCACT 1 -- us2k12Minor allele frequency- C:0.03WA EA 238
    rs1420370721,2
    C--42462259(+) TGTAG-/CCTCCT 1 -- us2k10--------
    rs1846559551,2
    --42462283(+) AAGAAC/TGGCCT 1 -- us2k10--------
    rs1875133941,2
    --42462285(+) GAATGG/TCCTCT 1 -- us2k10--------
    rs1145560081,2
    C,F--42462355(+) GCACTC/TTATCT 1 -- us2k12Minor allele frequency- T:0.04WA EA 238
    rs117185021,2
    C,F,H--42462363(+) tcttcC/Tatttc 1 -- us2k123Minor allele frequency- T:0.24NS EA NA WA 2764
    rs1926413641,2
    --42462416(+) ATAAGA/GACACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for VIPR1 (42530791 - 42579065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for VIPR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527430CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VIPR1
    DNA2.0 Custom Variant and Variant Library Synthesis for VIPR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 192321    OMIM disorders: --

    1 disease for VIPR1:    
    About MalaCards
    idiopathic achalasia


    Find genes that share disorders with VIPR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for VIPR1 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 82.2 66 10548340 (2), 8985192 (1), 10191201 (1), 10421665 (1) (see all 56)
    hepatitis c chronic 62.8 15 11851900 (2), 12717846 (2), 9557291 (2), 8818972 (1) (see all 10)
    hepatitis chronic 57.4 9 10421665 (1), 7685404 (1), 9580880 (1), 8314302 (1) (see all 8)
    infection chronic 46.2 4 8985192 (1), 8875612 (1), 11424122 (1), 12665923 (1)
    viremia 42.3 9 18167197 (4), 7815542 (1)
    hepatitis 27 10 7518526 (3), 10421665 (1), 18180071 (1), 7525524 (1) (see all 7)
    liver diseases 26.9 4 14962225 (1), 9620342 (1), 9443106 (1), 9557291 (1)
    liver cirrhosis 24.4 3 7525524 (1), 10440804 (1)
    virus infection 16.9 2 9443106 (1), 14718618 (1)
    hepatoblastoma 15.9 1 15484277 (1)

    Genetic Association Database (GAD): VIPR1
    Human Genome Epidemiology (HuGE) Navigator: VIPR1 (6 documents)

    Export disorders for VIPR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VIPR1 gene, integrated from 10 sources (see all 290):
    (articles sorted by number of sources associating them with VIPR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B*2705 in Sardinia. (PubMed id 18668120)1, 4, 9 Paladini F....Sorrentino R. (Genes Immun. 2008)
    2. Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene. (PubMed id 7708752)1, 3, 9 Sreedharan S.P....Goetzl E.J. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    4. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
    5. Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene. (PubMed id 19309439)1, 4 Paladini F....Sorrentino R. (Neurogastroenterol. Motil. 2009)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production. (PubMed id 9928020)1, 2 Knudsen S.M.... Fahrenkrug J. (Ann. N. Y. Acad. Sci. 1998)
    9. Highly conserved aspartate 68, tryptophan 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP. (PubMed id 7818527)1, 2 Couvineau A....Laburthe M. (Biochem. Biophys. Res. Commun. 1995)
    10. Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains. (PubMed id 8179610)1, 2 Couvineau A.... Laburthe M. (Biochem. Biophys. Res. Commun. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7433 HGNC: 12694 AceView: VIPR1 Ensembl:ENSG00000114812 euGenes: HUgn7433
    ECgene: VIPR1 Kegg: 7433 H-InvDB: VIPR1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for VIPR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for VIPR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for VIPR1 gene:
    Search GeneIP for patents involving VIPR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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