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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VIPR1 Gene

protein-coding GIFtS: 64
GCID: GC03P042520

vasoactive intestinal peptide receptor 1

Explore 50 diseases affiliated with
VIPR1 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Vasoactive Intestinal Peptide Receptor 1¹ ²		V1RG²
VPAC1¹ ² ³		VAPC1²
HVR1¹ ²		VIPR²
RDC1¹ ²		VIRG²
VPAC1R¹ ²		VPCAP1R²
PACAP-R-2² ³		Pituitary Adenylate Cyclase Activating Polypeptide Receptor, Type II²
PACAP-R2² ³		Vasoactive Intestinal Polypeptide Receptor 1²
VIP-R-1² ³		VIP And PACAP Receptor 1²
PACAP Type II Receptor² ³		VIP Receptor, Type I²
II²		Pituitary Adenylate Cyclase-Activating Polypeptide Type II Receptor³

External Ids:	HGNC: 12694¹	Entrez Gene: 7433²	Ensembl: ENSG00000114812⁷	OMIM: 192321⁵	UniProtKB: P32241³

Export aliases for VIPR1 gene to outside databases

Previous GC identifers: GC03P041848 GC03P041710 GC03P042350 GC03P042504 GC03P042505

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VIPR1:

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is

involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal

epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding

protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for

this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241

Function: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl

cyclase. The affinity is VIP = PACAP-27 > PACAP-38

summary for VIPR1:

Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently

divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous

system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart

and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival,

regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine

release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes

encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIPR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VIPR1 gene promoter:
NF-1/L NF-1 AP-1 Pax-5 SREBP-1c Nkx2-5 SREBP-1b GATA-1 SREBP-1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VIPR1 promoter sequence

Search SABiosciences Chromatin IP Primers for VIPR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VIPR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p22

VIPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIPR1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P042520: view genomic region (about GC identifiers)

Start:	42,530,791 bp from pter	End:	42,579,065 bp from pter
Size:	48,275 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241 (See protein sequence)

Recommended Name: Vasoactive intestinal polypeptide receptor 1 precursor

Size: 457 amino acids; 51547 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

3 PDB 3D structures from and Proteopedia for VIPR1:

1OF2 (3D)

1OGT (3D)

3B3I (3D)

Secondary accessions: A5JUT9 B4DEB5 Q15871 Q6P2M6

Alternative splicing: 3 isoforms: P32241-1 P32241-2 P32241-3

Explore the universe of human proteins at neXtProt for VIPR1: NX_P32241

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P32241

VIPR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001238811.1 NP_001238812.1 NP_001238813.1 NP_001238814.1 NP_004615.2

ENSEMBL proteins:

ENSP00000394950 ENSP00000415013 ENSP00000393215 ENSP00000388479 ENSP00000403680

ENSP00000403478 ENSP00000327246 ENSP00000396204 ENSP00000445701 ENSP00000415371

Reactome Protein details: P32241
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant VIPR1 Protein
	Browse R&D Systems for human recombinant proteins
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	Novus Biologicals VIPR1 Proteins Novus Biologicals VIPR1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VIPR1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8179610

VIPR1 for ontologies About GeneDecksing

VIPR1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of VIPR1
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	Novus Biologicals VIPR1 Antibodies
	Search for Antibodies for VIPR1 at Abcam
	Uscn Antibodies for VIPR1
	ThermoFisher Antibody for VIPR1

Assay Products for VIPR1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VIPR1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VIPR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VIPR1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017983 GPCR_2_secretin-like_CS

IPR001879 GPCR_2_extracellular_dom

IPR001771 GPCR_2_VIP_rcpt_1

IPR017981 GPCR_2-like

IPR000832 GPCR_2_secretin-like

Graphical View of Domain Structure for InterPro Entry P32241

ProtoNet protein and cluster: P32241

3 Blocks protein families:

IPB000832 G-protein coupled receptors family 2 (secretin-like)

IPB001571 Vasoactive intestinal peptide receptor signature

IPB001771 Vasoactive intestinal peptide receptor 1 signature

UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241

Similarity: Belongs to the G-protein coupled receptor 2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241

Function: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl

cyclase. The affinity is VIP = PACAP-27 > PACAP-38

Genatlas biochemistry entry for VIPR1:

vasoactive intestinal peptide receptor 1,G protein coupled,secretin receptor superfamily

miRNA Products:		OriGene 3'-UTR Clone: VIPR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIPR1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate VIPR1:
		hsa-miR-615-3p hsa-miR-3921
		SwitchGear 3'UTR luciferase reporter plasmid: VIPR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VIPR1 (see all 7) OriGene shRNA RFP: VIPR1 OriGene siRNA: VIPR1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIPR1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for VIPR1

Clone Products:		EMD Millipore Clones for the Expression of VIPR1
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		GenScript: all cDNA clones in your preferred vector: VIPR1 (NM_004624)
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Cell Line Products:		GenScript VIPR1-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for VIPR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIPR1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004999	vasoactive intestinal polypeptide receptor activity	IEA	--

VIPR1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for VIPR1:

Increased cell number in G1, s

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Vipr1^tm1Msod for VIPR1
8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vipr1):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	endocrine/exocrine gland
growth/size	homeostasis/metabolism	mortality/aging

VIPR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Adenylate cyclase-activating neuropeptides

Adenylate cyclase-activating neuropeptides

1.00

Selected targets of GCR-alpha

Selected targets of GCR-alpha

1.00

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

1.00

GPCRs, Class B Secretin-like

GPCRs, Class B Secretin-like

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for VIPR1

	Adenylate cyclase-activating neuropeptides
	Selected targets of GCR-alpha

3 BioSystems Pathways for VIPR1

	SIDS Susceptibility Pathways
	GPCRs, Class B Secretin-like
	Glucocorticoid receptor regulatory network

4 Reactome Pathways for VIPR1

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (s) signalling events

1 Kegg Pathway (Kegg details for VIPR1):

Neuroactive ligand-receptor interaction

VIPR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VIPR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/81 Interacting proteins for VIPR1 (P32241^{2, 3} ENSP00000327246⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 81)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM2	P62158²^,³	MINT-51637 I2D: score=3
CALM3	P62158²^,³	MINT-51637 I2D: score=3
HLA-B	P03989²^,³	MINT-8144492 I2D: score=1
CALM1	P62158²^,³, ENSP00000349467⁴	MINT-51637 I2D: score=3 STRING: ENSP00000349467
GNAQ	P50148³, ENSP00000286548⁴	I2D: score=2 STRING: ENSP00000286548

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006936	muscle contraction	TAS	8390245
GO:0006955	immune response	TAS	8390245
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8179610
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8390245
GO:0007268	synaptic transmission	TAS	8390245

VIPR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

VIPR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for VIPR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)	VIP antagonist	--
[Ala2,8,9,11,19,22,24,25,27,28]-VIP	Highly selective VPAC1 agonist	[866552-34-3]
[Ala11,22,28]VIP	Potent, highly selective VPAC1 agonist	[291524-04-4]
VIP (6-28) (human, rat, porcine, bovine)	VIP antagonist	[69698-54-0]
VIP (human, rat, mouse, rabbit, canine, porcine)	Involved in neurotransmission, smooth muscle relaxation	[40077-57-4]

10/15 Novoseek chemical compound relationships for VIPR1 gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenylate	77.3	37	16019382 (2), 10769164 (2), 9920725 (2), 10698193 (1) (see all 31)
aequorin	39	3	11587546 (1), 12196112 (1), 11981043 (1)
ribavirin	25.4	1	16038475 (1)
cyclic amp	16.9	4	11587546 (1), 10933794 (1), 11398176 (1), 9152366 (1)
alanine	14.7	4	11851900 (1), 9620342 (1), 8314302 (1), 9443106 (1)
forskolin	13.7	2	11027674 (1), 11138925 (1)
glucose	4.05	3	11978642 (1), 12525492 (1)
lipid	1.75	1	17393515 (1)
gtp	0	1	15589042 (1)
nitric oxide	0	1	11193883 (1)

Search CenterWatch for drugs/clinical trials and news about VIPR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VIPR1 gene (5 alternative transcripts):

NM_001251882.1 NM_001251883.1 NM_001251884.1 NM_001251885.1 NM_004624.3

Unigene Cluster for VIPR1:

Vasoactive intestinal peptide receptor 1

Hs.348500 [show with all ESTs]

Unigene Representative Sequence: AK126759

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000433647(uc021wwl.1) ENST00000473495 ENST00000490161 ENST00000487545

ENST00000450274 ENST00000436487 ENST00000443646 ENST00000439910 ENST00000439731

ENST00000325123(uc003clf.2 uc011azn.2 uc011azl.1 uc011azm.1 uc003clg.2)

ENST00000446673 ENST00000473575 ENST00000495189 ENST00000465338 ENST00000498102

ENST00000543411 ENST00000438259

miRNA Products:		OriGene 3'-UTR Clone: VIPR1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIPR1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate VIPR1:
		hsa-miR-615-3p hsa-miR-3921
		SwitchGear 3'UTR luciferase reporter plasmid: VIPR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIPR1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VIPR1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VIPR1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: VIPR1 (NM_004624)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIPR1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VIPR1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIPR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIPR1

Additional cDNA sequence:

AK056819.1 AK123943.1 AK126759.1 AK293548.1 AK294609.1 AK298115.1 AK314334.1 BC064424.1

EF577396.1 L13288.1 L20295.1 X75299.1

8 DOTS entries:

DT.101981721 DT.87016636 DT.95278328 DT.100039235 DT.97834355 DT.95130428 DT.120861608 DT.100029880

24/119 AceView cDNA sequences (see all 119):

R73300 BI820237 BQ689146 R46451 H45098 BQ686892 H45409 R72302

R72351 BM985121 R46758 W32571 T16182 BI910800 BI820314 BM742129

CB305819 NM_004624 R73210 BI763932 X75299 H74168 AI797007 AI872991

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for VIPR1 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11a	·	11b	·	11c	^	12	^	13a	·	13b	·	13c	^	14	^
SP1:							-		-		-		-		-		-		-		-																-						-
SP2:																							-														-						-
SP3:																							-														-						-
SP4:																							-		-												-						-		-		-		-
SP5:																							-		-												-						-

ExUns:	15a	·	15b	·	15c	·	15d	^	16	^	17	^	18a	·	18b	^	19	^	20a	·	20b
SP1:	-										-		-
SP2:	-										-		-
SP3:											-		-
SP4:	-
SP5:

ECgene alternative splicing isoforms for VIPR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VIPR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCATCTGG

About this image

VIPR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See VIPR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VIPR1

SOURCE GeneReport for Unigene cluster: Hs.348500

UniProtKB/Swiss-Prot: VIPR1_HUMAN, P32241

Tissue specificity: In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart,

kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78,

Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT

SABiosciences Expression via Pathway-Focused PCR Array including VIPR1:

G Protein Coupled Receptors 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VIPR1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIPR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIPR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for VIPR1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	VIPR1¹	vasoactive intestinal peptide receptor 1	67.74(n) 66.74(a)		395329 NM_001097523.1 NP_001090992.1
lizard (Anolis carolinensis)	Reptilia	VIPR1⁶	--	67(a)	1 ↔ 1	6(2533176-2565790)
zebrafish (Danio rerio)	Actinopterygii	vipr1b¹	vasoactive intestinal peptide receptor 1b	63.94(n) 60.34(a)		503868 NM_001013353.1 NP_001013371.1
honey bee (Apis mellifera)	Insecta	-- -- (see all 4)	--	3(a) 27(a) (see all 4)	many ↔ many many ↔ many (see all 4)	Group9.2(517685-519657) Group9.2(531165-533904)

ENSEMBL Gene Tree for VIPR1 (if available)
TreeFam Gene Tree for VIPR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VIPR1 gene

GLP1R² GHRHR² GCGR² CALCR² CRHR2² PTH1R² CRHR1² PTH2R²

CALCRL² ADCYAP1R1² SCTR² GLP2R² VIPR2² GIPR²

16 SIMAP similar genes for VIPR1 using alignment to 6 protein entries: VIPR1_HUMAN (see all proteins):

SCTR VIPR2 GHRHR GLP2R ADCYAP1R1 CALCRL

GIPR CRHR1 GCGR PTH1R GLP1R CRHR2

PTHR2 PTH2R CALCR HCTR-6

VIPR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144950832^1,2	C	other	89918805(+)	`TCTGGG/AGGTAC`	10	/R /G	mis¹ syn¹		1		NA	4550
rs200621312^1,2	C	other	89918819(+)	`TGAGCG/AGAAGT`	10	/Q /R /G	mis¹		1		EU	1323
rs78625393^1,2	F,	--	42528899(+)	`CTCTCT/CTCACT`	1	--	us2k¹		2		WA EA	238
rs142037072^1,2	C,	--	42528978(+)	`TGTAG-/CCTCCT`	1	--	us2k¹		0	--	--	--	--
rs184655955^1,2		--	42529002(+)	`AAGAAC/TGGCCT`	1	--	us2k¹		0	--	--	--	--
rs187513394^1,2		--	42529004(+)	`GAATGG/TCCTCT`	1	--	us2k¹		0	--	--	--	--
rs114556008^1,2	C,F,	--	42529074(+)	`GCACTC/TTATCT`	1	--	us2k¹		2		WA EA	238
rs11718502^1,2	C,F,H,	--	42529082(+)	`TCTTCC/TATTTC`	1	--	us2k¹		23		NS EA NA WA	2764
rs192641364^1,2		--	42529135(+)	`ATAAGA/GACACT`	1	--	us2k¹		0	--	--	--	--
rs139669318^1,2		--	42529160(+)	`GAAAGA/GTCTAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VIPR1 (42530791 - 42579065 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VIPR1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VIPR1

DNA2.0 Custom Variant and Variant Library Synthesis for VIPR1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VIPR1 for disorders           About GeneDecksing

OMIM gene information: 192321    OMIM disorders: --

20/50 diseases for VIPR1 (see all 50):    About MalaCards

primitive neuroectodermal tumor myasthenia gravis scimitar syndrome pituitary adenoma

neuroectodermal tumors liver cirrhosis hepatitis c allergic rhinitis

inflammatory bowel disease dysentery heterotopia bladder carcinoma

myasthenia achalasia neuronitis endometrial carcinoma

hepatoblastoma rhinitis liver disease keratoconjunctivitis

10/35 Novoseek disease relationships for VIPR1 gene (see all 35) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis c	82.2	66	10548340 (2), 8985192 (1), 10191201 (1), 10421665 (1) (see all 56)
hepatitis c chronic	62.8	15	11851900 (2), 12717846 (2), 9557291 (2), 8818972 (1) (see all 10)
hepatitis chronic	57.4	9	10421665 (1), 7685404 (1), 9580880 (1), 8314302 (1) (see all 8)
infection chronic	46.2	4	8985192 (1), 8875612 (1), 11424122 (1), 12665923 (1)
viremia	42.3	9	18167197 (4), 7815542 (1)
hepatitis	27	10	7518526 (3), 10421665 (1), 18180071 (1), 7525524 (1) (see all 7)
liver diseases	26.9	4	14962225 (1), 9620342 (1), 9443106 (1), 9557291 (1)
liver cirrhosis	24.4	3	7525524 (1), 10440804 (1)
virus infection	16.9	2	9443106 (1), 14718618 (1)
hepatoblastoma	15.9	1	15484277 (1)

Human Genome Epidemiology (HuGE) Navigator: VIPR1 (6 documents)

Export disorders for VIPR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VIPR1 gene, integrated from 9 sources (see all 287):
(articles sorted by number of sources associating them with VIPR1)

Utopia: connect your pdf to the dynamic
world of online information

Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene. (PubMed id 7708752)^{1, 3, 9} Sreedharan S.P....Goetzl E.J. (1995)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production. (PubMed id 9928020)^{1, 2} Knudsen S.M.... Fahrenkrug J. (1998)
Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP. (PubMed id 7818527)^{1, 2} Couvineau A....Laburthe M. (1995)
Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains. (PubMed id 8179610)^{1, 2} Couvineau A.... Laburthe M. (1994)
Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor. (PubMed id 7917790)^{1, 2} Gagnon A.W.... Elshourbagy N.A. (1994)
Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor. (PubMed id 8390245)^{1, 2} Sreedharan S.P.... Goetzl E.J. (1993)
Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros. (PubMed id 11812772)^{1, 9} Dorsam G. and Goetzl E.J. (2002)
VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium. (PubMed id 16037943)^{1, 9} Chignard N....Housset C. (2005)
VIP receptor 1 (VPAC1) promoter targets the expression of a reporter gene to cerebellum and adrenal medulla in transgenic mice. (PubMed id 14599709)^{1, 9} Karacay B....Bonthius D.J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7433	HGNC: 12694	AceView: VIPR1	Ensembl:ENSG00000114812	euGenes: HUgn7433
ECgene: VIPR1	Kegg: 7433	H-InvDB: VIPR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VIPR1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for VIPR1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for VIPR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for VIPR1 gene:
Search GeneIP for patents involving VIPR1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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In Situ Hybridization Assays from
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ThermoFisher Antibody for VIPR1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIPR1

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VIPR1 Gene

vasoactive intestinal peptide receptor 1

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VIPR1 (Gene Symbol)
Vasoactive Intestinal Peptide Receptor 1
VPAC1
HVR1
RDC1
VPAC1R
PACAP-R-2
PACAP-R2
VIP-R-1
PACAP Type II Receptor
II
V1RG
VAPC1
VIPR
VIRG
VPCAP1R
Pituitary Adenylate Cyclase Activating Polypeptide Receptor, Type II
Vasoactive Intestinal Polypeptide Receptor 1
VIP And PACAP Receptor 1
VIP Receptor, Type I
Pituitary Adenylate Cyclase-Activating Polypeptide Type II Receptor

Cirrhosis
BREAST CARCINOMA
Medulloblastoma
Superinfection
Hepatitis Chronic
PITUITARY ADENOMA
Carcinoma
PROSTATE CARCINOMA
Liver diseases
Breast Cancer
Adenocarcinoma
HEPATOCELLULAR CARCINOMA
Cancer
Hypertension Pulmonary
Cancer Lung
Viremia
ADENOCARCINOMA GASTRIC
Lymphoma
Meningioma
Ewings sarcoma
Hepatitis
immunodeficiency
Hepatitis C Chronic
BLADDER CARCINOMA
ENDOMETRIAL CARCINOMA
prostate cancer
Tumors
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VIPR1 Gene

vasoactive intestinal peptide receptor 1

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