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Aliases for VIPR1 Gene

Aliases for VIPR1 Gene

  • Vasoactive Intestinal Peptide Receptor 1 2 3 5
  • VIP And PACAP Receptor 1 2 3
  • PACAP Type II Receptor 3 4
  • PACAP-R-2 3 4
  • PACAP-R2 3 4
  • VIP-R-1 3 4
  • VPAC1 3 4
  • Pituitary Adenylate Cyclase Activating Polypeptide Receptor, Type II 3
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type II Receptor 4
  • Type 1 Vasoactive Intestinal Peptide Receptor 3
  • Vasoactive Intestinal Polypeptide Receptor 1 3
  • VIP Receptor, Type I 3
  • VPAC1 Receptor 3
  • VPCAP1R 3
  • VPAC1R 3
  • VAPC1 3
  • RDC1 3
  • HVR1 3
  • V1RG 3
  • VIPR 3
  • VIRG 3
  • II 3

External Ids for VIPR1 Gene

Previous GeneCards Identifiers for VIPR1 Gene

  • GC03P041848
  • GC03P041710
  • GC03P042350
  • GC03P042504
  • GC03P042505

Summaries for VIPR1 Gene

Entrez Gene Summary for VIPR1 Gene

  • This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for VIPR1 Gene

VIPR1 (Vasoactive Intestinal Peptide Receptor 1) is a Protein Coding gene. Diseases associated with VIPR1 include Holoprosencephaly-3 and Inflammatory Diarrhea. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and vasoactive intestinal polypeptide receptor activity. An important paralog of this gene is ADCYAP1R1.

UniProtKB/Swiss-Prot for VIPR1 Gene

  • This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.

Tocris Summary for VIPR1 Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.

Gene Wiki entry for VIPR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIPR1 Gene

Genomics for VIPR1 Gene

Regulatory Elements for VIPR1 Gene

Enhancers for VIPR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G042177 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -309.4 -309357 4.7 HDGF PKNOX1 SIN3A ARID4B FOS DEK SP5 JUNB NFYC SMARCB1 VIPR1 VIPR1-AS1 TRAK1 TPMTP2 GC03P042217
GH03G042544 1.2 Ensembl ENCODE dbSUPER 11 +55.9 55860 1.3 ELF3 CTCF SOX13 GATAD2A FOXA2 NFIA FOXA3 NR3C1 REST NR2F2 SEC22C NKTR SS18L2 VIPR1 CCDC13 CCDC13-AS1 VIPR1-AS1
GH03G042514 1 Ensembl ENCODE dbSUPER 12.5 +26.5 26540 2.1 BCOR CTCF ESRRA HLF RAD21 VIPR1 NKTR VIPR1-AS1
GH03G042539 1.1 ENCODE dbSUPER 11 +50.7 50735 0.2 ZNF76 ZNF48 RAD21 ZNF335 ZNF143 KLF13 GATAD2B REST ZEB2 NR2F2 SS18L2 SEC22C VIPR1 CCDC13 CCDC13-AS1 VIPR1-AS1
GH03G042526 0.8 Ensembl dbSUPER 15 +37.8 37802 0.6 CTCF EGR1 ETV1 ZNF512 PRDM1 GABPA EGR2 VIPR1 SS18L2 LYZL4 SEC22C NKTR VIPR1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VIPR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VIPR1 Gene

Chromosome:
3
Start:
42,489,299 bp from pter
End:
42,537,573 bp from pter
Size:
48,275 bases
Orientation:
Plus strand

Genomic View for VIPR1 Gene

Genes around VIPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VIPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VIPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIPR1 Gene

Proteins for VIPR1 Gene

  • Protein details for VIPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32241-VIPR1_HUMAN
    Recommended name:
    Vasoactive intestinal polypeptide receptor 1
    Protein Accession:
    P32241
    Secondary Accessions:
    • A5JUT9
    • B3KPV1
    • B4DEB5
    • B4DGI4
    • F5H1F5
    • G3V0I1
    • Q15871
    • Q6P2M6

    Protein attributes for VIPR1 Gene

    Size:
    457 amino acids
    Molecular mass:
    51547 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIPR1 Gene

    Alternative splice isoforms for VIPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VIPR1 Gene

Post-translational modifications for VIPR1 Gene

  • Glycosylation at isoforms=5, 258, isoforms=4, 5, 269, isoforms=4, 5, 2100, and posLast=290290
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for VIPR1 Gene

Domains & Families for VIPR1 Gene

Graphical View of Domain Structure for InterPro Entry

P32241

UniProtKB/Swiss-Prot:

VIPR1_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with VIPR1: view

Function for VIPR1 Gene

Molecular function for VIPR1 Gene

GENATLAS Biochemistry:
vasoactive intestinal peptide receptor 1,G protein coupled,secretin receptor superfamily
UniProtKB/Swiss-Prot Function:
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.

Gene Ontology (GO) - Molecular Function for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004999 vasoactive intestinal polypeptide receptor activity TAS,IEA --
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with VIPR1: view
genes like me logo Genes that share phenotypes with VIPR1: view

Animal Models for VIPR1 Gene

MGI Knock Outs for VIPR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for VIPR1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VIPR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VIPR1 Gene

Localization for VIPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIPR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VIPR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8179610
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with VIPR1: view

Pathways & Interactions for VIPR1 Gene

genes like me logo Genes that share pathways with VIPR1: view

SIGNOR curated interactions for VIPR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for VIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 8390245
GO:0006955 immune response TAS 8390245
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8179610
genes like me logo Genes that share ontologies with VIPR1: view

Drugs & Compounds for VIPR1 Gene

(37) Drugs for VIPR1 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Secretin Approved, Investigational Pharma Full agonist, Agonist, binder 31
Bay 55-9837 Pharma Agonist Potent and selective VPAC2 agonist 0
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) Pharma VIP receptor antagonist 0
[D-p-Cl-Phe6,Leu17]-VIP Pharma Selective VIP receptor antagonist 0
VIP (6-28) (human, rat, porcine, bovine) Pharma VIP receptor antagonist 0

(8) Additional Compounds for VIPR1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]VIP
Full agonist, Agonist
[Lys<sup>15</sup>,Arg<sup>16</sup>,Leu<sup>27</sup>]VIP-(1?ao7)/GRF-(8?ao27)-NH<sub>2</sub>
Full agonist, Agonist
VIP (human, rat, mouse, rabbit, canine, porcine)
40077-57-4

(5) Tocris Compounds for VIPR1 Gene

Compound Action Cas Number
[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) VIP receptor antagonist 93965-89-0
[D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist 102805-45-8
Bay 55-9837 Potent and selective VPAC2 agonist 463930-25-8
VIP (6-28) (human, rat, porcine, bovine) VIP receptor antagonist 69698-54-0
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation 40077-57-4

(6) ApexBio Compounds for VIPR1 Gene

genes like me logo Genes that share compounds with VIPR1: view

Drug Products

Transcripts for VIPR1 Gene

Unigene Clusters for VIPR1 Gene

Vasoactive intestinal peptide receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for VIPR1

Alternative Splicing Database (ASD) splice patterns (SP) for VIPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10: - - - - - - - - -
SP11:
SP12: -
SP13:
SP14: -
SP15: -
SP16:

ExUns: 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for VIPR1 Gene

GeneLoc Exon Structure for
VIPR1
ECgene alternative splicing isoforms for
VIPR1

Expression for VIPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VIPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIPR1 Gene

This gene is overexpressed in Lung (x10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VIPR1 Gene



NURSA nuclear receptor signaling pathways regulating expression of VIPR1 Gene:

VIPR1

SOURCE GeneReport for Unigene cluster for VIPR1 Gene:

Hs.348500

mRNA Expression by UniProt/SwissProt for VIPR1 Gene:

P32241-VIPR1_HUMAN
Tissue specificity: In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT.

Evidence on tissue expression from TISSUES for VIPR1 Gene

  • Intestine(4.5)
  • Lung(4.5)
  • Nervous system(4.5)
  • Liver(4.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with VIPR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VIPR1 Gene

Orthologs for VIPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VIPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VIPR1 34
  • 95.44 (n)
cow
(Bos Taurus)
Mammalia VIPR1 34 35
  • 89.93 (n)
dog
(Canis familiaris)
Mammalia VIPR1 34 35
  • 89.25 (n)
mouse
(Mus musculus)
Mammalia Vipr1 34 16 35
  • 85.85 (n)
rat
(Rattus norvegicus)
Mammalia Vipr1 34
  • 84.83 (n)
oppossum
(Monodelphis domestica)
Mammalia VIPR1 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves VIPR1 34 35
  • 67.82 (n)
lizard
(Anolis carolinensis)
Reptilia VIPR1 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497291 34
  • 66.83 (n)
zebrafish
(Danio rerio)
Actinopterygii vipr1b 34 35
  • 63.94 (n)
vipr1a 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 36
  • 29 (a)
Species where no ortholog for VIPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIPR1 Gene

ENSEMBL:
Gene Tree for VIPR1 (if available)
TreeFam:
Gene Tree for VIPR1 (if available)

Paralogs for VIPR1 Gene

(15) SIMAP similar genes for VIPR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with VIPR1: view

Variants for VIPR1 Gene

Sequence variations from dbSNP and Humsavar for VIPR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000156453 -- 42,501,054(+) GAGGG(A/G)CTCCA intron-variant, upstream-variant-2KB
rs1000178806 -- 42,510,245(+) TAATT(C/G)TCTAA intron-variant
rs1000354431 -- 42,489,904(+) TCTCC(C/T)ACCAT intron-variant
rs1000402206 -- 42,501,390(+) TCTGC(C/T)CAGGG intron-variant, upstream-variant-2KB
rs1000423484 -- 42,503,997(+) GCTCA(C/T)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VIPR1 Gene

Variant ID Type Subtype PubMed ID
nsv527430 CNV loss 19592680

Variation tolerance for VIPR1 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VIPR1 Gene

Human Gene Mutation Database (HGMD)
VIPR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VIPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIPR1 Gene

Disorders for VIPR1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for VIPR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
holoprosencephaly-3
  • holoprosencephaly 3
inflammatory diarrhea
achalasia
  • achalasia of cardia
idiopathic achalasia
  • achalasia
- elite association - COSMIC cancer census association via MalaCards
Search VIPR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VIPR1

Genetic Association Database (GAD)
VIPR1
Human Genome Epidemiology (HuGE) Navigator
VIPR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VIPR1
genes like me logo Genes that share disorders with VIPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VIPR1 Gene

Publications for VIPR1 Gene

  1. A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B*2705 in Sardinia. (PMID: 18668120) Paladini F. … Sorrentino R. (Genes Immun. 2008) 3 22 46 64
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64
  3. Oligonucleotide DNA microarray profiling of lung adenocarcinoma revealed significant downregulation and deletions of vasoactive intestinal peptide receptor 1. (PMID: 20014941) Mlakar V. … Glavac D. (Cancer Invest. 2010) 3 22 64
  4. Vasoactive intestinal peptide (VIP) receptor expression in monocyte-derived macrophages from COPD patients. (PMID: 20026142) Burian B. … Petkov V. (Peptides 2010) 3 22 64
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64

Products for VIPR1 Gene

  • Addgene plasmids for VIPR1

Sources for VIPR1 Gene

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