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VIPAS39 Gene

protein-coding   GIFtS: 42
GCID: GC14M077895

VPS33B Interacting Protein, Apical-Basolateral Polarity...

(Previous name: chromosome 14 open reading frame 133)
(Previous symbol: C14orf133)
  See VIPAS39-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
VPS33B Interacting Protein, Apical-Basolateral Polarity Regulator,
Spe-39 Homolog1 2
     Chromosome 14 Open Reading Frame 1331
C14orf1331 2 3 5     VPS33B Interacting Protein1
SPE392 3 5     SPE-392
VIPAR2 3 5     VPS16B2
hSPE-392 3     Protein Spe-39 Homolog2
VPS33B-Interacting Protein In Apical-Basolateral Polarity Regulator2 3     Spermatogenesis-Defective Protein 39 Homolog2
VPS33B-Interacting Protein In Polarity And Apical Restriction2 3     VPS33B-Interacting Protein Involved In Polarity And Apical Protein
Restriction2
Apical-Basolateral Polarity Regulator1     

External Ids:    HGNC: 203471   Entrez Gene: 638942   Ensembl: ENSG000001514457   OMIM: 6134015   UniProtKB: Q9H9C13   

Export aliases for VIPAS39 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VIPAS39 Gene:
This gene encodes a protein involved in the sorting of lysosomal proteins. Mutations in this gene are associated
with ARCS2 (arthrogryposis, renal dysfunction, and cholestasis-2). Alternative splicing results in multiple
transcript variants.(provided by RefSeq, Jul 2010)

GeneCards Summary for VIPAS39 Gene:
VIPAS39 (VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog) is a protein-coding gene. Diseases associated with VIPAS39 include vipas39-related arthrogryposis, renal dysfunction, and cholestasis syndrome, and arthrogryposis, renal dysfunction, and cholestasis 2.

UniProtKB/Swiss-Prot: SPE39_HUMAN, Q9H9C1
Function: May play a role in vesicular trafficking during spermatogenesis (By similarity). Plays a role in
lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes.
May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via
the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of
E-cadherin

Gene Wiki entry for VIPAS39 (C14orf133) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for VIPAS39
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVIPAS39 promoter sequence
   Search Chromatin IP Primers for VIPAS39

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VIPAS39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3-q31   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3-q31

VIPAS39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIPAS39 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M077895:  view genomic region     (about GC identifiers)

Start:
77,893,018 bp from pter      End:
77,924,295 bp from pter
Size:
31,278 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPE39_HUMAN, Q9H9C1 (See protein sequence)
Recommended Name: Spermatogenesis-defective protein 39 homolog  
Size: 493 amino acids; 57005 Da
Subunit: Associates with the homotypic fusion and vacuole protein sorting (HOPS) complex. Interacts with VPS33A
and VPS33B. Interacts with RAB11A
Sequence caution: Sequence=AAD09624.1; Type=Erroneous gene model prediction; Sequence=BAB14951.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DPI6 O95434 Q9H7E1 Q9H9I9
Alternative splicing: 2 isoforms:  Q9H9C1-1   Q9H9C1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VIPAS39: NX_Q9H9C1

Explore proteomics data for VIPAS39 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VIPAS39 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001180243.1  NP_001180244.1  NP_001180245.1  NP_001180246.1  NP_071350.2  

    ENSEMBL proteins: 
     ENSP00000339122   ENSP00000452181   ENSP00000452191   ENSP00000404815   ENSP00000451857  
     ENSP00000452176   ENSP00000313098  

    VIPAS39 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for VIPAS39 (5 products) 

     
    antibodies-online peptides for VIPAS39

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    antibodies-online antibodies for VIPAS39 (9 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019177 Golgin_subfamily_A_member_5

    Graphical View of Domain Structure for InterPro Entry Q9H9C1

    ProtoNet protein and cluster: Q9H9C1

    UniProtKB/Swiss-Prot: SPE39_HUMAN, Q9H9C1
    Similarity: Belongs to the SPE39 family


    Find genes that share domains with VIPAS39           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPE39_HUMAN, Q9H9C1
    Function: May play a role in vesicular trafficking during spermatogenesis (By similarity). Plays a role in
    lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes.
    May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via
    the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of
    E-cadherin

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with VIPAS39           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for VIPAS39

    miRNA
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    miRTarBase miRNAs that target VIPAS39:
    hsa-mir-26b-5p (MIRT029282)

    Block miRNA regulation of human, mouse, rat VIPAS39 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPE39_HUMAN, Q9H9C1: Cytoplasm (By similarity). Cytoplasmic vesicle (By similarity). Early endosome. Recycling
    endosome. Late endosome. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome IDA19109425
    GO:0005770late endosome IDA19109425
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0030897colocalizes with HOPS complex IDA19109425

    Find genes that share ontologies with VIPAS39           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VIPAS39
    Interactions:

        Search GeneGlobe Interaction Network for VIPAS39

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for VIPAS39 (Q9H9C11, 2, 3 ENSP000003391224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VPS33BQ9H2671, 2, 3, ENSP000003276504EBI-749080,EBI-749072 MINT-8380411 MINT-8380389 MINT-67422 MINT-8380455 I2D: score=5 STRING: ENSP00000327650
    VPS41P497541, 3, ENSP000003094574EBI-749080,EBI-2130459 I2D: score=1 STRING: ENSP00000309457
    VPS33AQ96AX13, ENSP000002671994I2D: score=2 STRING: ENSP00000267199
    DMDP115323I2D: score=4 
    Vps11Q91W861EBI-749080,EBI-2527812
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006886intracellular protein transport IMP19109425
    GO:0007283spermatogenesis IEA--
    GO:0008333endosome to lysosome transport IMP19109425

    Find genes that share ontologies with VIPAS39           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VIPAS39 (SPE39)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VIPAS39 gene (5 alternative transcripts): 
    NM_001193314.1  NM_001193315.1  NM_001193316.1  NM_001193317.1  NM_022067.3  

    Unigene Cluster for VIPAS39:

    VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
    Hs.16157  [show with all ESTs]
    Unigene Representative Sequence: NM_001193314
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343765 ENST00000553888(uc001xtt.2 uc001xtv.2 uc021rwu.1)
    ENST00000557658(uc001xtu.2 uc010tvj.2) ENST00000448935 ENST00000556412
    ENST00000553576 ENST00000553691 ENST00000555854 ENST00000557466 ENST00000556909
    ENST00000327028
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat VIPAS39
      QuantiFast Probe-based Assays in human, mouse, rat VIPAS39

    Additional mRNA sequence: 

    AK022769.1 AK022925.1 AK024661.1 AK098254.1 AK222706.1 AK297388.1 AK298354.1 BC015054.1 
    CR457294.1 

    9 DOTS entries:

    DT.95189699  DT.100816509  DT.120768397  DT.115582  DT.102825173  DT.95189698  DT.40125016  DT.101955511 
    DT.100644307 

    Selected AceView cDNA sequences (see all 159):

    AI219191 AI241688 CF551999 BC015054 BU844899 BU170181 BM551809 AA278570 
    BG251534 AI285320 CB118895 BQ049006 BM665674 AK098254 CD674878 CR610207 
    BI334835 BQ929541 Z40295 BF988899 BE139577 CR607042 BX102809 CR457294 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VIPAS39    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                                      -                                       
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for VIPAS39

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VIPAS39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    VIPAS39 Expression
    About this image

    VIPAS39 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VIPAS39 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16157
        Custom PCR Arrays for VIPAS39
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for VIPAS39 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vipas391 , 5 VPS33B interacting protein, apical-basolateral polarity more1, 5 88.77(n)1
    95.55(a)1
      12 (41.44 cM)5
    1047991  NM_001142581.11  NP_001136053.11 
     872388755 
    chicken
    (Gallus gallus)
    Aves VIPAR1 VPS33B interacting protein, apical-basolateral polarity more 74.59(n)
    80.99(a)
      423377  XM_004941838.1  XP_004941895.1 
    lizard
    (Anolis carolinensis)
    Reptilia VIPAS396
    VPS33B interacting protein, apical-basolateral pol...
    70(a)
    1 ↔ 1
    1(20691912-20719589)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33642 Xenopus laevis transcribed sequence with weak similarity more 76.91(n)    BX853921.1 
    zebrafish
    (Danio rerio)
    Actinopterygii xbp12 Danio rerio clone RK047A1E09 chromosome 14 open reading more 75.79(n)    AY394945.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps16B1 Vacuolar protein sorting 16B 43.56(n)
    30.06(a)
      43521  NM_143474.2  NP_651731.1 
    worm
    (Caenorhabditis elegans)
    Secernentea spe-396
    Protein SPE-39, isoform a
    21(a)
    1 ↔ 1
    V(6785457-6787867) WBGene00004975


    ENSEMBL Gene Tree for VIPAS39 (if available)
    TreeFam Gene Tree for VIPAS39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VIPAS39 gene
    1 SIMAP similar gene for VIPAS39 using alignment to 3 protein entries:     SPE39_HUMAN (see all proteins):
    C14orf133

    Find genes that share paralogs with VIPAS39           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VIPAS39 (see all 814)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003709251,2
    Cpathogenic158895644(+) CTGTCG/ACACCT 10 /R /* stg11Minor allele frequency- A:0.00EU 1211
    rs1135584961,2
    C--58067715(+) AAGTG-/AAAAAA 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs113883511,2
    C--58073184(+) GCTAAT/-TTTTG 5 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs359836311,2
    C--58076340(+) TCTCC-/AAAAAAAA 5 -- cds10--------
    rs594323681,2
    C--58078369(+) AAAAA-/ATAAAA 5 -- int10--------
    rs178240941,2
    C,F,H--58879624(+) ATGATC/ACTAAG 5 -- ds500130Minor allele frequency- A:0.10NA NS EA WA 3328
    rs1924301271,2
    C--58879675(+) GGAGCA/GGGAGA 5 -- ds50010--------
    rs1506378501,2
    --58879677(+) AGCGGA/GAGAGA 5 -- ds50010--------
    rs1387494681,2
    C--58879795(+) TGAAAA/GTAAAA 5 -- ut310--------
    rs42231,2
    C,F,A,H--58879939(+) GTGACA/GGGTCT 5 -- ut31 ese326Minor allele frequency- G:0.36MN EA NA NS WA 4352

    HapMap Linkage Disequilibrium report for VIPAS39 (77893018 - 77924295 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VIPAS39: --
    Human Gene Mutation Database (HGMD): VIPAS39
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VIPAS39
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613401   
    OMIM disorders: 613404  
    UniProtKB/Swiss-Prot: SPE39_HUMAN, Q9H9C1
  • Arthrogryposis, renal dysfunction and cholestasis syndrome 2 (ARCS2) [MIM:613404]: A multisystem
    disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal
    cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is
    common. Note=The disease is caused by mutations affecting the gene represented in this entry. In liver, CEACAM5
    and ABCB11 are mislocalized and E-cadherin expression is decreased

  • 5 diseases for VIPAS39:    
    About MalaCards
    vipas39-related arthrogryposis, renal dysfunction, and cholestasis syndrome    arthrogryposis, renal dysfunction, and cholestasis 2    arc syndrome    arthrogryposis, renal dysfunction, and cholestasis 1
    cholestasis


    Find genes that share disorders with VIPAS39           About GenesLikeMe


    Export disorders for VIPAS39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VIPAS39 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with VIPAS39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. (PubMed id 20190753)1, 2, 3 Cullinane A.R.... Gissen P. (Nat. Genet. 2010)
    2. SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery. (PubMed id 19109425)1, 2, 3 Zhu G.D.... L'hernault S.W. (Mol. Biol. Cell 2009)
    3. Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes. (PubMed id 23918659)1, 3 Tornieri K....Faundez V. (Hum. Mol. Genet. 2013)
    4. The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet I+-granule biogenesis. (PubMed id 23002115)1, 3 Urban D....Kahr W.H. (Blood 2012)
    5. Associations among genotype, clinical phenotype, and intracellular localization of trafficking proteins in ARC syndrome. (PubMed id 22753090)1, 3 Smith H....Gissen P. (Hum. Mutat. 2012)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63894 HGNC: 20347 AceView: C14orf133 Ensembl:ENSG00000151445 euGenes: HUgn63894
    ECgene: VIPAS39 H-InvDB: VIPAS39

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VIPAS39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VIPAS39 gene:
    Search GeneIP for patents involving VIPAS39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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