Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



VIP Gene

protein-coding   GIFtS: 63
GCID: GC06P153164

Vasoactive Intestinal Peptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Vasoactive Intestinal Peptide1 2
prepro-VIP1 2
PHM272
VIP Peptides2

External Ids:    HGNC: 126931   Entrez Gene: 74322   Ensembl: ENSG000001464697   OMIM: 1923205   UniProtKB: P012823   

Export aliases for VIP gene to outside databases

Previous GC identifers: GC06P152633 GC06P152967 GC06P153103 GC06P153102 GC06P150635


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for VIP Gene:
The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes
vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea,
stomach and gall bladder. Alternative splicing occurs at this locus and two transcript variants encoding distinct
isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for VIP Gene:
VIP (vasoactive intestinal peptide) is a protein-coding gene. Diseases associated with VIP include vasomotor rhinitis, and impotence. GO annotations related to this gene include neuropeptide hormone activity and hormone activity. An important paralog of this gene is ADCYAP1.

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282
Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases
glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder
Function: PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with
similar efficacy as calcitonin

summary for VIP Gene:
Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently
divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous
system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart
and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival,
regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine
release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes
encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIP (Vasoactive intestinal peptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VIP gene promoter:
         STAT1   AP-1   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVIP promoter sequence
   Search Chromatin IP Primers for VIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q24-q27

VIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P153164:  view genomic region     (about GC identifiers)

Start:
153,071,933 bp from pter      End:
153,080,900 bp from pter
Size:
8,968 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282 (See protein sequence)
Recommended Name: VIP peptides precursor  
Size: 170 amino acids; 19169 Da
2 PDB 3D structures from and Proteopedia for VIP:
2RRH (3D)        2RRI (3D)    
Secondary accessions: Q5TCY8 Q5TCY9 Q96QK3
Alternative splicing: 2 isoforms:  P01282-1   P01282-2   

Explore the universe of human proteins at neXtProt for VIP: NX_P01282

Explore proteomics data for VIP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003372.1  NP_919416.1  

    ENSEMBL proteins: 
     ENSP00000356213   ENSP00000356212   ENSP00000410356  
    Reactome Protein details: P01282

    VIP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for VIP
    OriGene Protein Over-expression Lysate for VIP
    OriGene Custom MassSpec
    OriGene Custom Protein Services for VIP
    GenScript Custom Purified and Recombinant Proteins Services for VIP
    Novus Biologicals VIP Protein
    Novus Biologicals VIP Lysates
    Sino Biological Recombinant Protein for VIP
    Sino Biological Cell Lysate for VIP
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VIP

    VIP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of VIP
    R&D Systems Antibodies for VIP
    OriGene Antibodies for VIP
    OriGene Custom Antibody Services for VIP
    Novus Biologicals VIP Antibodies
    Abcam antibodies for VIP
    Cloud-Clone Corp. Antibodies for VIP
    ThermoFisher Antibodies for VIP
    LSBio Antibodies in human, mouse, rat for VIP

    VIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VIP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VIP
    Cloud-Clone Corp. CLIAs for VIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR000532 Glucagon_GIP_secretin_VIP
     IPR015523 VIP

    Graphical View of Domain Structure for InterPro Entry P01282

    ProtoNet protein and cluster: P01282

    1 Blocks protein domain: IPB000532 Glucagon/GIP/secretin/VIP

    UniProtKB/Swiss-Prot: VIP_HUMAN, P01282
    Similarity: Belongs to the glucagon family


    VIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VIP_HUMAN, P01282
    Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases
    glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder
    Function: PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with
    similar efficacy as calcitonin

         Genatlas biochemistry entry for VIP:
    precursor of vasoactive intestinal and PHM (intestinal peptide homolog of porcine PHI-27) peptide

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005179hormone activity IDA9603988
    GO:0005184neuropeptide hormone activity TAS10096039
    GO:0005515protein binding IPI--
         
    VIP for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vip):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     mortality/aging  normal  reproductive system  respiratory system 

    VIP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Viptm1Clw for VIP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target VIP:
    hsa-mir-335-5p (MIRT016951)

    Block miRNA regulation of human, mouse, rat VIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VIP (see all 18):
    hsa-miR-30c hsa-miR-30d hsa-miR-373* hsa-miR-183* hsa-miR-30a hsa-miR-3148 hsa-miR-556-3p hsa-miR-205
    SwitchGear 3'UTR luciferase reporter plasmidVIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VIP
    Predesigned siRNA for gene silencing in human, mouse, rat VIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VIP

    Clone
    Products:
         
    OriGene clones in human, mouse for VIP (see all 13)
    OriGene ORF clones in mouse, rat for VIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): VIP (NM_194435)
    Sino Biological Human cDNA Clone for VIP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VIP
    Browse ESI BIO Cell Lines and PureStem Progenitors for VIP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    VIP_HUMAN, P01282: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043025neuronal cell body IEA--

    VIP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for VIP About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2G alpha (s) signalling events
    G alpha (s) signalling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for VIP
        G alpha (s) signalling events



    VIP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including VIP: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for VIP (P012821, 2, 3 ENSP000003562134) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274871, 2, 3, ENSP000003537314EBI-751454,EBI-2871277 MINT-8090811 MINT-8090848 I2D: score=1 STRING: ENSP00000353731
    FAPQ128841, 2, 3, ENSP000001887904EBI-751454,EBI-4319803 MINT-8090577 MINT-8094195 I2D: score=1 STRING: ENSP00000188790
    MEOX2P502222, 3, ENSP000002620414MINT-68122 I2D: score=5 STRING: ENSP00000262041
    VIPR1P322411, 3, ENSP000003272464EBI-6656819,EBI-3917984 I2D: score=1 STRING: ENSP00000327246
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2864067 I2D: score=3 STRING: ENSP00000357292
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS10096039
    GO:0007589body fluid secretion TAS4035357
    GO:0007611learning or memory IEA--
    GO:0008284positive regulation of cell proliferation TAS8389448

    VIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for VIP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist[102805-45-8]
    Bay 55-9837Potent and selective VPAC2 agonist[463930-25-8]
    VIP (6-28) (human, rat, porcine, bovine) VIP antagonist[69698-54-0]
    VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission, smooth muscle relaxation [40077-57-4]
    [Ala11,22,28]VIP Potent, highly selective VPAC1 agonist [291524-04-4]

    Selected Novoseek inferred chemical compound relationships for VIP gene (see all 148)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 87.2 481 2167366 (4), 9418704 (4), 8698838 (3), 7623776 (3) (see all 99)
    pacap 38 81.8 55 9002987 (5), 12147212 (5), 7623776 (4), 7910101 (3) (see all 22)
    pacaps 77 17 8698838 (3), 10578152 (1), 8752138 (1), 20043043 (1) (see all 8)
    viphyb 74.8 2 11859929 (1), 10670826 (1)
    forskolin 71.5 127 11165399 (4), 19026713 (3), 1371513 (3), 11678758 (3) (see all 72)
    cyclic amp 70.6 144 1384276 (5), 9789791 (5), 7741049 (4), 15800375 (4) (see all 59)
    helospectin i 68.8 9 8680719 (3), 15003357 (3), 1847591 (1)
    d-ala(1)-peptide t amide 66.9 5 7575755 (1), 10446313 (1)
    helospectin 66.5 6 8680719 (1), 1438980 (1), 9928018 (1), 10880980 (1)
    spantide 62.6 2 7679135 (1)



    VIP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for VIP gene (2 alternative transcripts): 
    NM_003381.3  NM_194435.2  

    Unigene Cluster for VIP:

    Vasoactive intestinal peptide
    Hs.53973  [show with all ESTs]
    Unigene Representative Sequence: NM_003381
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367244(uc003qpe.3) ENST00000367243(uc003qpf.3 uc010kjd.3)
    ENST00000431366
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat VIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VIP (see all 18):
    hsa-miR-30c hsa-miR-30d hsa-miR-373* hsa-miR-183* hsa-miR-30a hsa-miR-3148 hsa-miR-556-3p hsa-miR-205
    SwitchGear 3'UTR luciferase reporter plasmidVIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for VIP
    Predesigned siRNA for gene silencing in human, mouse, rat VIP
    Clone
    Products:
         
    OriGene clones in human, mouse for VIP (see all 13)
    OriGene ORF clones in mouse, rat for VIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): VIP (NM_194435)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VIP
    OriGene qSTAR qPCR primer pairs in human, mouse for VIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VIP
      QuantiTect SYBR Green Assays in human, mouse, rat VIP
      QuantiFast Probe-based Assays in human, mouse, rat VIP

    Additional mRNA sequence: 

    AK291959.1 AK313950.1 BC009794.1 M36634.1 M54930.1 

    1 DOTS entry:

    DT.109681 

    21 AceView cDNA sequences:

    BF445774 NM_194435 AU105582 NM_003381 BQ723487 CR593090 BX092558 AU099390 
    BC009794 M36634 AL533330 AL533286 BQ900960 AI217172 BQ720510 BM971673 
    AW779139 BF668372 BF679063 BG199555 M54930 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for VIP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:              -                                                               
    SP2:              -                                                               
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for VIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    VIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    VIP Expression
    About this image


    VIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Midbrain tegmentum
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Metencephalon
    VIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.53973
        Pathway & Disease-focused RT2 Profiler PCR Array including VIP: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VIP
    OriGene qSTAR qPCR primer pairs in human, mouse for VIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VIP
    QuantiTect SYBR Green Assays in human, mouse, rat VIP
    QuantiFast Probe-based Assays in human, mouse, rat VIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for VIP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vip1 , 5 vasoactive intestinal polypeptide1, 5 80.59(n)1
    79.41(a)1
      10 (1.97 cM)5
    223531  NM_011702.21  NP_035832.11 
     56392185 
    chicken
    (Gallus gallus)
    Aves VIP1 vasoactive intestinal peptide 71.13(n)
    64.57(a)
      396323  NM_205366.2  NP_990697.2 
    lizard
    (Anolis carolinensis)
    Reptilia VIP6
    vasoactive intestinal peptide
    50(a)
    1 ↔ 1
    1(215967016-215981804)
    African clawed frog
    (Xenopus laevis)
    Amphibia vip-A2 vasoactive intestinal peptide 76.96(n)    BC043792.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vip1 vasoactive intestinal peptide 66.67(n)
    71.11(a)
      795653  NM_001114553.2  NP_001108025.1 


    ENSEMBL Gene Tree for VIP (if available)
    TreeFam Gene Tree for VIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for VIP gene
    ADCYAP12  
    1 SIMAP similar gene for VIP using alignment to 2 protein entries:     VIP_HUMAN (see all proteins):
    ADCYAP1

    VIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for VIP (see all 243)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471428131,2
    C--153070005(+) CAGGA-/TAAATT
            
    TGACT
    2 -- us2k10--------
    rs1874650191,2
    --153070053(+) AAGCAC/TCCAAA 2 -- us2k10--------
    rs1918686851,2
    --153070069(+) AGCTGA/GCTACA 2 -- us2k10--------
    rs1420116091,2
    --153070163(+) ACCTGA/CAGATG 2 -- us2k10--------
    rs1150685091,2
    C,F--153070186(+) CATTTT/GCAAAT 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs122128491,2
    C,F,H--153070203(+) GCTTTC/GTAGTT 2 -- us2k113Minor allele frequency- G:0.15NS EA WA CSA NA 1202
    rs1829640451,2
    --153070212(+) TTTAAA/TTTCAT 2 -- us2k10--------
    rs1458659911,2
    --153070350(+) CTATAA/GTTACT 2 -- us2k10--------
    rs14072671,2
    C,F,O,A,H--153070451(+) CATTTG/TTCTGT 2 -- us2k122Minor allele frequency- T:0.09EA NA NS WA 1896
    rs1858928571,2
    C--153070511(+) TCACTA/GAGAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for VIP (153071933 - 153080900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for VIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2017e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): VIP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VIP
    DNA2.0 Custom Variant and Variant Library Synthesis for VIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 192320    OMIM disorders: --

    Selected diseases for VIP (see all 158):    
    About MalaCards
    vasomotor rhinitis    impotence    dyshidrosis    normal pressure hydrocephalus
    vipoma    wdha syndrome    subcortical arteriosclerotic encephalopathy    cholera
    achalasia    ganglioneuroma    fibrocalculous pancreatic diabetes    megacolon
    megaesophagus    ganglioneuroblastoma    islet cell tumor    headache
    constipation    somatostatinoma    cluster headache    colon adenocarcinoma

    11 diseases from the University of Copenhagen DISEASES database for VIP:
    Diarrhea     Cholera     Pancreatic cholera     Neuroendocrine tumor
    Ganglioneuroma     Neuroblastoma     Hypokalemia     Asthma
    Hirschsprung's disease     Constipation     Hyperprolactinemia

    VIP for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for VIP gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wdha syndrome 80.2 17 2153088 (3), 15051093 (2), 19184565 (1), 11762360 (1) (see all 8)
    vipoma 78 26 19184565 (2), 8383153 (2), 16001675 (1), 7588006 (1) (see all 12)
    megacolon acquired 66.6 6 8689918 (3), 7506433 (2), 10859084 (1)
    neuroendocrine tumors 57.2 10 9285932 (1), 11795252 (1), 11476170 (1), 17043625 (1) (see all 7)
    achlorhydria 54.6 10 16001675 (1), 7588006 (1), 20216072 (1), 2171816 (1) (see all 6)
    ganglioneuroma 53.7 13 8354485 (3), 7576950 (3), 1300605 (1), 12739135 (1)
    somatostatinoma 48.7 1 1974023 (1)
    carcinoid 46.1 13 7935635 (3), 9426418 (1), 8266771 (1), 9189133 (1) (see all 9)
    glucagonoma 45.4 2 12206598 (1), 8606627 (1)
    ganglioneuroblastoma 44.1 1 12739135 (1)

    Genetic Association Database (GAD): VIP
    Human Genome Epidemiology (HuGE) Navigator: VIP (25 documents)

    Export disorders for VIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for VIP gene, integrated from 10 sources (see all 1493):
    (articles sorted by number of sources associating them with VIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PubMed id 1318039)1, 2, 9 Kitamura K.... Eto T. (Biochem. Biophys. Res. Commun. 1992)
    2. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
    3. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    5. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (PubMed id 20554694)1, 4 Kovanen L....Partonen T. (Alcohol Alcohol. 2010)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    7. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. (PubMed id 19470168)1, 4 Englund A....Partonen T. (J Circadian Rhythms 2009)
    8. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    9. Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)1, 4 Tremblay K....Laprise C. (PLoS ONE 2008)
    10. Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation. (PubMed id 17448763)1, 4 Garcia-Barcelo M....Tam P.K. (J. Pediatr. Surg. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7432 HGNC: 12693 AceView: VIP Ensembl:ENSG00000146469 euGenes: HUgn7432
    ECgene: VIP H-InvDB: VIP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for VIP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Vasoactive_intestinal_peptide

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for VIP gene:
    Search GeneIP for patents involving VIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of VIP
     
     EMD Millipore genomic analysis products

      
     Antibodies for VIP (VIP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for VIP   OriGene RNAi products in human, mouse, rat for VIP  
     OriGene qPCR primer pairs and template standards for VIP   OriGene Protein Over-expression Lysate for VIP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for VIP  
     OriGene qSTAR qPCR primer pairs in human, mouse for VIP   OriGene Purified Protein for VIP  
     OriGene ORF clones in mouse, rat for VIP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VIP   OriGene Custom Protein Services for VIP  

     
     
     Block miRNA regulation of human, mouse, rat VIP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing VIP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VIP Predesigned siRNA for gene silencing in human, mouse, rat VIP
     QuantiFast Probe-based Assays in human, mouse, rat VIP QuantiTect SYBR Green Assays in human, mouse, rat VIP
     PCR Arrays including human, mouse, rat VIP Search Chromatin IP Primers for VIP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VIP  GeneGlobe Interaction Network for VIP
     Regulatory tfbs in VIP promoter
     GenScript Custom Purified and Recombinant Proteins Services for VIP GenScript cDNA clones with any tag delivered in your preferred vector for VIP
     GenScript Custom Assay Services for VIP GenScript Custom overexpressing Cell Line Services for VIP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for VIP
     Proteins for VIP
     Cell Lysates for VIP
     cDNA Clones for VIP
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     VIP antibodies
     VIP proteins
     VIP lysates
     Antibodies for VIP
     See all of Abcam's Antibodies, Kits and Proteins for VIP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for VIP
     Antibodies for VIP
     ELISAs for VIP
     CLIAs for VIP



     Browse ESI BIO Cell Lines and PureStem Progenitors for VIP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP
     SwitchGear 3'UTR luciferase reporter plasmids for VIP
     SwitchGear Promoter luciferase reporter plasmids for VIP
     ThermoFisher Antibodies for VIP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VIP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VIP
     LSBio Antibodies in human, mouse, rat for VIP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VIP gene at Home site.
    Version: 3.12.162 19 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4