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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VIP Gene

protein-coding   GIFtS: 63
GCID: GC06P153164

Vasoactive Intestinal Peptide

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Vasoactive Intestinal Peptide1 2
prepro-VIP1 2
PHM272
VIP Peptides2

External Ids:    HGNC: 126931   Entrez Gene: 74322   Ensembl: ENSG000001464697   OMIM: 1923205   UniProtKB: P012823   

Export aliases for VIP gene to outside databases

Previous GC identifers: GC06P152633 GC06P152967 GC06P153103 GC06P153102 GC06P150635


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VIP Gene:
The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes
vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea,
stomach and gall bladder. Alternative splicing occurs at this locus and two transcript variants encoding distinct
isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for VIP Gene: 
VIP (vasoactive intestinal peptide) is a protein-coding gene. Diseases associated with VIP include vipoma, and wdha syndrome, and among its related super-pathways are Signaling by GPCR and Class B/2 (Secretin family receptors). GO annotations related to this gene include neuropeptide hormone activity and hormone activity. An important paralog of this gene is ADCYAP1.

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282
Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases
glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder
Function: PHM and PHV also cause vasodilation

summary for VIP Gene:
Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently
divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous
system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart
and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival,
regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine
release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes
encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIP (Vasoactive intestinal peptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VIP gene promoter:
         STAT1   AP-1   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVIP promoter sequence
   Search SABiosciences Chromatin IP Primers for VIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q24-q27

VIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P153164:  view genomic region     (about GC identifiers)

Start:
153,071,933 bp from pter      End:
153,080,900 bp from pter
Size:
8,968 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282 (See protein sequence)
Recommended Name: VIP peptides precursor  
Size: 170 amino acids; 19169 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for VIP:
2RRH (3D)        2RRI (3D)    
Secondary accessions: Q5TCY8 Q5TCY9 Q96QK3
Alternative splicing: 2 isoforms:  P01282-1   P01282-2   

Explore the universe of human proteins at neXtProt for VIP: NX_P01282

Explore proteomics data for VIP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01282

  • VIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VIP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003372.1  NP_919416.1  

    ENSEMBL proteins: 
     ENSP00000356213   ENSP00000356212   ENSP00000410356  
    Reactome Protein details: P01282
    Human Recombinant Protein Products for VIP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for VIP
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for VIP
    GenScript Custom Purified and Recombinant Proteins Services for VIP
    Novus Biologicals VIP Protein
    Novus Biologicals VIP Lysates
    Sino Biological Recombinant Protein for VIP
    Sino Biological Cell Lysate for VIP 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VIP 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043025neuronal cell body IEA--

    VIP for ontologies           About GeneDecksing



    VIP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of VIP
    R&D Systems Antibodies for VIP
    OriGene Antibodies for VIP
    OriGene Custom Antibody Services for VIP
    GenScript Custom Superior Antibodies Services for VIP
    Novus Biologicals VIP Antibodies
    Abcam antibodies for VIP
    Cloud-Clone Corp. Antibodies for VIP 
    ThermoFisher Antibodies for VIP
    LSBio Antibodies in human, mouse, rat for VIP 

    Assay Products for VIP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VIP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VIP 
    Cloud-Clone Corp. CLIAs for VIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR015523 VIP
     IPR000532 Glucagon_GIP_secretin_VIP

    Graphical View of Domain Structure for InterPro Entry P01282

    ProtoNet protein and cluster: P01282

    1 Blocks protein domain: IPB000532 Glucagon/GIP/secretin/VIP

    UniProtKB/Swiss-Prot: VIP_HUMAN, P01282
    Similarity: Belongs to the glucagon family


    VIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VIP_HUMAN, P01282
    Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases
    glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder
    Function: PHM and PHV also cause vasodilation

         Genatlas biochemistry entry for VIP:
    precursor of vasoactive intestinal and PHM (intestinal peptide homolog of porcine PHI-27) peptide

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005179hormone activity IDA9603988
    GO:0005184neuropeptide hormone activity TAS10096039
    GO:0005515protein binding IPI--
         
    VIP for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vip):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     mortality/aging  normal  reproductive system  respiratory system 

    VIP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Viptm1Clw for VIP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VIP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VIP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIP
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate VIP (see all 18):
    hsa-miR-30c hsa-miR-30d hsa-miR-373* hsa-miR-183* hsa-miR-30a hsa-miR-3148 hsa-miR-556-3p hsa-miR-205
    SwitchGear 3'UTR luciferase reporter plasmidVIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VIP
    Sirion Biotech Customized adenovirus for overexpression of VIP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for VIP (see all 14)
    OriGene ORF clones in mouse, rat for VIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): VIP (NM_194435)
    Sino Biological Human cDNA Clone for VIP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP
    Sirion Biotech Customized lentivirus for stable overexpression of VIP 
                         Customized lentivirus expression plasmids for stable overexpression of VIP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VIP
    Search LifeMap BioReagents cell lines for VIP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Prostacyclin signalling through prostacyclin receptor
    G alpha (s) signalling events0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for VIP
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    G alpha (s) signalling events



    VIP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for VIP (P012822, 3 ENSP000003562134) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8090811 MINT-8090848 I2D: score=1 STRING: ENSP00000353731
    FAPQ128842, 3, ENSP000001887904MINT-8090577 MINT-8094195 I2D: score=1 STRING: ENSP00000188790
    MEOX2P502222, 3, ENSP000002620414MINT-68122 I2D: score=5 STRING: ENSP00000262041
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2864067 I2D: score=3 STRING: ENSP00000357292
    MMEP084733, ENSP000003536794I2D: score=1 STRING: ENSP00000353679
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS10096039
    GO:0007589body fluid secretion TAS4035357
    GO:0007611learning or memory IEA--
    GO:0008284positive regulation of cell proliferation TAS8389448

    VIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VIP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for VIP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist[102805-45-8]
    Bay 55-9837Potent and selective VPAC2 agonist[463930-25-8]
    VIP (6-28) (human, rat, porcine, bovine) VIP antagonist[69698-54-0]
    VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission, smooth muscle relaxation [40077-57-4]
    [Ala11,22,28]VIP Potent, highly selective VPAC1 agonist [291524-04-4]

    10/148 Novoseek inferred chemical compound relationships for VIP gene (see all 148)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 87.2 481 2167366 (4), 9418704 (4), 8698838 (3), 7623776 (3) (see all 99)
    pacap 38 81.8 55 9002987 (5), 12147212 (5), 7623776 (4), 7910101 (3) (see all 22)
    pacaps 77 17 8698838 (3), 10578152 (1), 8752138 (1), 20043043 (1) (see all 8)
    viphyb 74.8 2 11859929 (1), 10670826 (1)
    forskolin 71.5 127 11165399 (4), 19026713 (3), 1371513 (3), 11678758 (3) (see all 72)
    cyclic amp 70.6 144 1384276 (5), 9789791 (5), 7741049 (4), 15800375 (4) (see all 59)
    helospectin i 68.8 9 8680719 (3), 15003357 (3), 1847591 (1)
    d-ala(1)-peptide t amide 66.9 5 7575755 (1), 10446313 (1)
    helospectin 66.5 6 8680719 (1), 1438980 (1), 9928018 (1), 10880980 (1)
    spantide 62.6 2 7679135 (1)

    Search CenterWatch for drugs/clinical trials and news about VIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VIP gene (2 alternative transcripts): 
    NM_003381.3  NM_194435.2  

    Unigene Cluster for VIP:

    Vasoactive intestinal peptide
    Hs.53973  [show with all ESTs]
    Unigene Representative Sequence: NM_003381
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367244(uc003qpe.3) ENST00000367243(uc003qpf.3 uc010kjd.3)
    ENST00000431366

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIP
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate VIP (see all 18):
    hsa-miR-30c hsa-miR-30d hsa-miR-373* hsa-miR-183* hsa-miR-30a hsa-miR-3148 hsa-miR-556-3p hsa-miR-205
    SwitchGear 3'UTR luciferase reporter plasmidVIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIP
    Clone
    Products:
         
    OriGene clones in human, mouse for VIP (see all 14)
    OriGene ORF clones in mouse, rat for VIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): VIP (NM_194435)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP
    Sirion Biotech Customized lentivirus for stable overexpression of VIP 
                         Customized lentivirus expression plasmids for stable overexpression of VIP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VIP
    OriGene qSTAR qPCR primer pairs in human, mouse for VIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIP

    Additional mRNA sequence: 

    AK291959.1 AK313950.1 BC009794.1 M36634.1 M54930.1 

    1 DOTS entry:

    DT.109681 

    21 AceView cDNA sequences:

    BX092558 BF445774 AU099390 NM_194435 BQ723487 AU105582 NM_003381 CR593090 
    BQ900960 M36634 BM971673 AL533330 AI217172 BQ720510 BC009794 AL533286 
    BF679063 BG199555 BF668372 AW779139 M54930 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for VIP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:              -                                                               
    SP2:              -                                                               
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for VIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VIP expression in normal human tissues (normalized intensities)      VIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    VIP Expression
    About this image


    VIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Septum   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
             visceral organ/mesonephros of male/mesonephric tubule of male   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)
             PERIPHERAL NERVOUS SYSTEM   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See VIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VIP

    SOURCE GeneReport for Unigene cluster: Hs.53973
        SABiosciences Expression via Pathway-Focused PCR Array including VIP: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VIP
    OriGene qSTAR qPCR primer pairs in human, mouse for VIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VIP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VIP gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vip1 , 5 vasoactive intestinal polypeptide1, 5 80.59(n)1
    79.41(a)1
      10 (1.97 cM)5
    223531  NM_011702.21  NP_035832.11 
     56392185 
    chicken
    (Gallus gallus)
    Aves VIP1 vasoactive intestinal peptide 67.3(n)
    59.49(a)
      396323  NM_205366.2  NP_990697.2 
    lizard
    (Anolis carolinensis)
    Reptilia VIP6
    vasoactive intestinal peptide
    52(a)
    1 ↔ 1
    1(215967016-215981804)
    African clawed frog
    (Xenopus laevis)
    Amphibia vip-A2 vasoactive intestinal peptide 76.96(n)    BC043792.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vip1 vasoactive intestinal peptide 66.67(n)
    71.11(a)
      795653  NM_001114553.1  NP_001108025.1 


    ENSEMBL Gene Tree for VIP (if available)
    TreeFam Gene Tree for VIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VIP gene
    ADCYAP12  
    1 SIMAP similar gene for VIP using alignment to 2 protein entries:     VIP_HUMAN (see all proteins):
    ADCYAP1

    VIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/243 SNPs in VIP are shown (see all 243)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471428131,2
    C--153070005(+) CAGGA-/TAAATT
            
    TGACT
    2 -- us2k10--------
    rs1874650191,2
    --153070053(+) AAGCAC/TCCAAA 2 -- us2k10--------
    rs1918686851,2
    --153070069(+) AGCTGA/GCTACA 2 -- us2k10--------
    rs1420116091,2
    --153070163(+) ACCTGA/CAGATG 2 -- us2k10--------
    rs1150685091,2
    C,F--153070186(+) CATTTT/GCAAAT 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs122128491,2
    C,F,H--153070203(+) GCTTTC/GTAGTT 2 -- us2k113Minor allele frequency- G:0.15NS EA WA CSA NA 1202
    rs1829640451,2
    --153070212(+) TTTAAA/TTTCAT 2 -- us2k10--------
    rs1458659911,2
    --153070350(+) CTATAA/GTTACT 2 -- us2k10--------
    rs14072671,2
    C,F,O,A,H--153070451(+) CATTTG/TTCTGT 2 -- us2k122Minor allele frequency- T:0.09EA NA NS WA 1896
    rs1858928571,2
    C--153070511(+) TCACTA/GAGAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for VIP (153071933 - 153080900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for VIP:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2017e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): VIP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VIP
    DNA2.0 Custom Variant and Variant Library Synthesis for VIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 192320    OMIM disorders: --

    20/150 diseases for VIP (see all 150):    About MalaCards
    vipoma    wdha syndrome    impotence    vasomotor rhinitis
    dyshidrosis    subcortical arteriosclerotic encephalopathy    ganglioneuroma    achalasia
    cholera    normal pressure hydrocephalus    megacolon    islet cell tumor
    ganglioneuroblastoma    headache    constipation    somatostatinoma
    cluster headache    rhinitis    hyperprolactinemia    multiple chemical sensitivity

    11 diseases from the University of Copenhagen DISEASES database for VIP:
    Diarrhea     Cholera     Pancreatic cholera     Neuroendocrine tumor
    Ganglioneuroma     Neuroblastoma     Hypokalemia     Asthma
    Hirschsprung's disease     Constipation     Hyperprolactinemia

    VIP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for VIP gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wdha syndrome 80.2 17 2153088 (3), 15051093 (2), 19184565 (1), 11762360 (1) (see all 8)
    vipoma 78 26 19184565 (2), 8383153 (2), 16001675 (1), 7588006 (1) (see all 12)
    megacolon acquired 66.6 6 8689918 (3), 7506433 (2), 10859084 (1)
    neuroendocrine tumors 57.2 10 9285932 (1), 11795252 (1), 11476170 (1), 17043625 (1) (see all 7)
    achlorhydria 54.6 10 16001675 (1), 7588006 (1), 20216072 (1), 2171816 (1) (see all 6)
    ganglioneuroma 53.7 13 8354485 (3), 7576950 (3), 1300605 (1), 12739135 (1)
    somatostatinoma 48.7 1 1974023 (1)
    carcinoid 46.1 13 7935635 (3), 9426418 (1), 8266771 (1), 9189133 (1) (see all 9)
    glucagonoma 45.4 2 12206598 (1), 8606627 (1)
    ganglioneuroblastoma 44.1 1 12739135 (1)

    Genetic Association Database (GAD): VIP
    Human Genome Epidemiology (HuGE) Navigator: VIP (25 documents)

    Export disorders for VIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VIP gene, integrated from 9 sources (see all 1488):
    (articles sorted by number of sources associating them with VIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PubMed id 1318039)1, 2, 9 Kitamura K.... Eto T. (1992)
    2. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CL OCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4 Soria V....Urretavizcaya M. (2010)
    3. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    4. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    5. Circadian clock gene polymorphisms in alcohol use dis orders and alcohol consumption. (PubMed id 20554694)1, 4 Kovanen L....Partonen T. (2010)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    7. NPAS2 and PER2 are linked to risk factors of the meta bolic syndrome. (PubMed id 19470168)1, 4 Englund A....Partonen T. (2009)
    8. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    9. Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)1, 4 Tremblay K....Laprise C. (2008)
    10. Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation. (PubMed id 17448763)1, 4 Garcia-Barcelo M....Tam P.K. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7432 HGNC: 12693 AceView: VIP Ensembl:ENSG00000146469 euGenes: HUgn7432
    ECgene: VIP H-InvDB: VIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VIP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Vasoactive_intestinal_peptide

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VIP gene:
    Search GeneIP for patents involving VIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Regulatory tfbs in VIP promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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