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Set Analyses:

VarElect

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VIP Gene

protein-coding GIFtS: 63
GCID: GC06P153164

Vasoactive Intestinal Peptide

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Vasoactive Intestinal Peptide¹ ²
prepro-VIP¹ ²
PHM27²
VIP Peptides²

External Ids:	HGNC: 12693¹	Entrez Gene: 7432²	Ensembl: ENSG00000146469⁷	OMIM: 192320⁵	UniProtKB: P01282³

Export aliases for VIP gene to outside databases

Previous GC identifers: GC06P152633 GC06P152967 GC06P153103 GC06P153102 GC06P150635

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VIP Gene:

The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes

vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea,

stomach and gall bladder. Alternative splicing occurs at this locus and two transcript variants encoding distinct

isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for VIP Gene:

VIP (vasoactive intestinal peptide) is a protein-coding gene. Diseases associated with VIP include vasomotor rhinitis, and impotence. GO annotations related to this gene include neuropeptide hormone activity and hormone activity. An important paralog of this gene is ADCYAP1.

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282

Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases

glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder

Function: PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with

similar efficacy as calcitonin

summary for VIP Gene:

Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently

divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous

system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart

and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival,

regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine

release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes

encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIP (Vasoactive intestinal peptide) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000006.12 NT_025741.16 NC_018917.2

Regulatory elements:

Regulatory transcription factor binding sites in the VIP gene promoter:
STAT1 AP-1 NRSF form 1 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VIP promoter sequence

Search Chromatin IP Primers for VIP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VIP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q24-q27

VIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIP gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P153164: view genomic region (about GC identifiers)

Start:	153,071,933 bp from pter	End:	153,080,900 bp from pter
Size:	8,968 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VIP_HUMAN, P01282 (See protein sequence)

Recommended Name: VIP peptides precursor

Size: 170 amino acids; 19169 Da

2 PDB 3D structures from and Proteopedia for VIP:

2RRH (3D)

2RRI (3D)

Secondary accessions: Q5TCY8 Q5TCY9 Q96QK3

Alternative splicing: 2 isoforms: P01282-1 P01282-2

Explore the universe of human proteins at neXtProt for VIP: NX_P01282

Explore proteomics data for VIP at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See VIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_003372.1 NP_919416.1

ENSEMBL proteins:

ENSP00000356213 ENSP00000356212 ENSP00000410356

Reactome Protein details: P01282

VIP Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for VIP OriGene Protein Over-expression Lysate for VIP OriGene Custom MassSpec OriGene Custom Protein Services for VIP
	GenScript Custom Purified and Recombinant Proteins Services for VIP
	Novus Biologicals VIP Protein Novus Biologicals VIP Lysates
	Sino Biological Recombinant Protein for VIP Sino Biological Cell Lysate for VIP
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for VIP

VIP Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of VIP
	R&D Systems Antibodies for VIP
	OriGene Antibodies for VIP OriGene Custom Antibody Services for VIP
	Novus Biologicals VIP Antibodies
	Abcam antibodies for VIP
	Cloud-Clone Corp. Antibodies for VIP
	ThermoFisher Antibodies for VIP
	LSBio Antibodies in human, mouse, rat for VIP

VIP Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for VIP
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VIP
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for VIP Cloud-Clone Corp. CLIAs for VIP

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

2 InterPro protein domains:

IPR000532 Glucagon_GIP_secretin_VIP

IPR015523 VIP

Graphical View of Domain Structure for InterPro Entry P01282

ProtoNet protein and cluster: P01282

1 Blocks protein domain: IPB000532 Glucagon/GIP/secretin/VIP

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282

Similarity: Belongs to the glucagon family

VIP for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: VIP_HUMAN, P01282

Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases

glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder

Function: PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with

similar efficacy as calcitonin

Genatlas biochemistry entry for VIP:

precursor of vasoactive intestinal and PHM (intestinal peptide homolog of porcine PHI-27) peptide

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005179	hormone activity	IDA	9603988
GO:0005184	neuropeptide hormone activity	TAS	10096039
GO:0005515	protein binding	IPI	--

VIP for ontologies About GeneDecksing

Phenotypes:
9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vip):

behavior/neurological	cardiovascular system	endocrine/exocrine gland	homeostasis/metabolism	immune system
mortality/aging	normal	reproductive system	respiratory system

VIP for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Vip^tm1Clw for VIP

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VIP

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VIP

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VIP

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VIP

miRNA Products:		miRTarBase miRNAs that target VIP: hsa-mir-335-5p (MIRT016951)

		Block miRNA regulation of human, mouse, rat VIP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate VIP (see all 18):
		hsa-miR-30c hsa-miR-30d hsa-miR-373* hsa-miR-183* hsa-miR-30a hsa-miR-3148 hsa-miR-556-3p hsa-miR-205

		SwitchGear 3'UTR luciferase reporter plasmid: VIP 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for VIP
		Predesigned siRNA for gene silencing in human, mouse, rat VIP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for VIP

Clone Products:		OriGene clones in human, mouse for VIP (see all 13) OriGene ORF clones in mouse, rat for VIP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): VIP (NM_194435)
		Sino Biological Human cDNA Clone for VIP
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VIP
		Browse ESI BIO Cell Lines and PureStem Progenitors for VIP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

VIP_HUMAN, P01282: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
cytoskeleton	2
nucleus	2
plasma membrane	2
cytosol	1
endoplasmic reticulum	1
mitochondrion	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0043025	neuronal cell body	IEA	--

VIP for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for VIP About

See pathways by source

SuperPath

Contained pathways About

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

G alpha (s) signalling events

G alpha (s) signalling events

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for VIP

G alpha (s) signalling events

VIP for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including VIP:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Interactions:

GeneGlobe Interaction Network for VIP

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for VIP (P01282^{1, 2, 3} ENSP00000356213⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487¹^,²^,³, ENSP00000353731⁴	EBI-751454,EBI-2871277 MINT-8090811 MINT-8090848 I2D: score=1 STRING: ENSP00000353731
FAP	Q12884¹^,²^,³, ENSP00000188790⁴	EBI-751454,EBI-4319803 MINT-8090577 MINT-8094195 I2D: score=1 STRING: ENSP00000188790
MEOX2	P50222²^,³, ENSP00000262041⁴	MINT-68122 I2D: score=5 STRING: ENSP00000262041
VIPR1	P32241¹^,³, ENSP00000327246⁴	EBI-6656819,EBI-3917984 I2D: score=1 STRING: ENSP00000327246
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2864067 I2D: score=3 STRING: ENSP00000357292

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Gene Ontology (GO): Selected biological process terms (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	10096039
GO:0007589	body fluid secretion	TAS	4035357
GO:0007611	learning or memory	IEA	--
GO:0008284	positive regulation of cell proliferation	TAS	8389448

VIP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for VIP available from Tocris Bioscience About this table

Compound	Action	CAS #
[D-p-Cl-Phe6,Leu17]-VIP	Selective VIP receptor antagonist	[102805-45-8]
Bay 55-9837	Potent and selective VPAC2 agonist	[463930-25-8]
VIP (6-28) (human, rat, porcine, bovine)	VIP antagonist	[69698-54-0]
VIP (human, rat, mouse, rabbit, canine, porcine)	Involved in neurotransmission, smooth muscle relaxation	[40077-57-4]
[Ala11,22,28]VIP	Potent, highly selective VPAC1 agonist	[291524-04-4]

Selected Novoseek inferred chemical compound relationships for VIP gene (see all 148) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenylate	87.2	481	2167366 (4), 9418704 (4), 8698838 (3), 7623776 (3) (see all 99)
pacap 38	81.8	55	9002987 (5), 12147212 (5), 7623776 (4), 7910101 (3) (see all 22)
pacaps	77	17	8698838 (3), 10578152 (1), 8752138 (1), 20043043 (1) (see all 8)
viphyb	74.8	2	11859929 (1), 10670826 (1)
forskolin	71.5	127	11165399 (4), 19026713 (3), 1371513 (3), 11678758 (3) (see all 72)
cyclic amp	70.6	144	1384276 (5), 9789791 (5), 7741049 (4), 15800375 (4) (see all 59)
helospectin i	68.8	9	8680719 (3), 15003357 (3), 1847591 (1)
d-ala(1)-peptide t amide	66.9	5	7575755 (1), 10446313 (1)
helospectin	66.5	6	8680719 (1), 1438980 (1), 9928018 (1), 10880980 (1)
spantide	62.6	2	7679135 (1)

VIP for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for VIP gene (2 alternative transcripts):

NM_003381.3 NM_194435.2

Unigene Cluster for VIP:

Vasoactive intestinal peptide

Hs.53973 [show with all ESTs]

Unigene Representative Sequence: NM_003381

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367244(uc003qpe.3) ENST00000367243(uc003qpf.3 uc010kjd.3)

ENST00000431366

miRNA Products:		Block miRNA regulation of human, mouse, rat VIP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate VIP (see all 18):
		hsa-miR-30c hsa-miR-30d hsa-miR-373* hsa-miR-183* hsa-miR-30a hsa-miR-3148 hsa-miR-556-3p hsa-miR-205

		SwitchGear 3'UTR luciferase reporter plasmid: VIP 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for VIP
		Predesigned siRNA for gene silencing in human, mouse, rat VIP

Clone Products:		OriGene clones in human, mouse for VIP (see all 13) OriGene ORF clones in mouse, rat for VIP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): VIP (NM_194435)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP

Primer Products:		OriGene qPCR primer pairs and template standards for VIP OriGene qSTAR qPCR primer pairs in human, mouse for VIP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat VIP
		QuantiTect SYBR Green Assays in human, mouse, rat VIP
		QuantiFast Probe-based Assays in human, mouse, rat VIP

Additional mRNA sequence:

AK291959.1 AK313950.1 BC009794.1 M36634.1 M54930.1

1 DOTS entry:

DT.109681

21 AceView cDNA sequences:

BF445774 NM_194435 AU105582 NM_003381 BQ723487 CR593090 BX092558 AU099390

BC009794 M36634 AL533330 AL533286 BQ900960 AI217172 BQ720510 BM971673

AW779139 BF668372 BF679063 BG199555 M54930

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for VIP About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:					-
SP2:					-
SP3:
SP4:

ECgene alternative splicing isoforms for VIP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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VIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

VIP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 8) fully expand


Brain (Nervous System) fully expand to see all 3 entries
Adult Dopaminergic Neurons Ventral Tegmental Area
Midbrain tegmentum

Dermis (Integumentary System) fully expand to see all 2 entries
Zigzag Dermal Papilla Cells Dermal Papilla

Gut Tube (Gastrointestinal Tract)
Foregut

Kidney (Urinary System)
Metanephros

Neural Tube (Nervous System)
Metencephalon

VIP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

VIP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.53973

Pathway & Disease-focused RT² Profiler PCR Array including VIP:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for VIP OriGene qSTAR qPCR primer pairs in human, mouse for VIP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat VIP
		QuantiTect SYBR Green Assays in human, mouse, rat VIP
		QuantiFast Probe-based Assays in human, mouse, rat VIP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for VIP gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Vip^{1 , 5}	vasoactive intestinal polypeptide^{1, 5}	80.59(n)¹ 79.41(a)¹		10 (1.97 cM)⁵ 22353¹ NM_011702.2¹ NP_035832.1¹ 5639218⁵
chicken (Gallus gallus)	Aves	VIP¹	vasoactive intestinal peptide	71.13(n) 64.57(a)		396323 NM_205366.2 NP_990697.2
lizard (Anolis carolinensis)	Reptilia	VIP⁶	vasoactive intestinal peptide	50(a)	1 ↔ 1	1(215967016-215981804)
African clawed frog (Xenopus laevis)	Amphibia	vip-A²	vasoactive intestinal peptide	76.96(n)		BC043792.1
zebrafish (Danio rerio)	Actinopterygii	vip¹	vasoactive intestinal peptide	66.67(n) 71.11(a)		795653 NM_001114553.2 NP_001108025.1

ENSEMBL Gene Tree for VIP (if available)
TreeFam Gene Tree for VIP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for VIP gene

ADCYAP1²

1 SIMAP similar gene for VIP using alignment to 2 protein entries: VIP_HUMAN (see all proteins):

ADCYAP1

VIP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147142813^1,2	C	--	153070005(+)	`CAGGA-/TAAATT TGACT`	2	--	us2k¹		0	--	--	--	--
rs187465019^1,2		--	153070053(+)	`AAGCAC/TCCAAA`	2	--	us2k¹		0	--	--	--	--
rs191868685^1,2		--	153070069(+)	`AGCTGA/GCTACA`	2	--	us2k¹		0	--	--	--	--
rs142011609^1,2		--	153070163(+)	`ACCTGA/CAGATG`	2	--	us2k¹		0	--	--	--	--
rs115068509^1,2	C,F	--	153070186(+)	`CATTTT/GCAAAT`	2	--	us2k¹		1		WA	118
rs12212849^1,2	C,F,H	--	153070203(+)	`GCTTTC/GTAGTT`	2	--	us2k¹		13		NS EA WA CSA NA	1202
rs182964045^1,2		--	153070212(+)	`TTTAAA/TTTCAT`	2	--	us2k¹		0	--	--	--	--
rs145865991^1,2		--	153070350(+)	`CTATAA/GTTACT`	2	--	us2k¹		0	--	--	--	--
rs1407267^1,2	C,F,O,A,H	--	153070451(+)	`CATTTG/TTCTGT`	2	--	us2k¹		22		EA NA NS WA	1896
rs185892857^1,2	C	--	153070511(+)	`TCACTA/GAGAAT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VIP (153071933 - 153080900 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for VIP: About this table

Variant ID	Type	Subtype	PubMed ID
dgv2017e1	CNV	Complex	17122850

Human Gene Mutation Database (HGMD): VIP

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing VIP

DNA2.0 Custom Variant and Variant Library Synthesis for VIP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 192320 OMIM disorders: --

Selected diseases for VIP (see all 158):
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vasomotor rhinitis impotence dyshidrosis normal pressure hydrocephalus

vipoma wdha syndrome subcortical arteriosclerotic encephalopathy cholera

achalasia ganglioneuroma fibrocalculous pancreatic diabetes megacolon

megaesophagus ganglioneuroblastoma islet cell tumor headache

constipation somatostatinoma cluster headache colon adenocarcinoma

11 diseases from the University of Copenhagen DISEASES database for VIP:

Diarrhea Cholera Pancreatic cholera Neuroendocrine tumor

Ganglioneuroma Neuroblastoma Hypokalemia Asthma

Hirschsprung's disease Constipation Hyperprolactinemia

VIP for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for VIP gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wdha syndrome	80.2	17	2153088 (3), 15051093 (2), 19184565 (1), 11762360 (1) (see all 8)
vipoma	78	26	19184565 (2), 8383153 (2), 16001675 (1), 7588006 (1) (see all 12)
megacolon acquired	66.6	6	8689918 (3), 7506433 (2), 10859084 (1)
neuroendocrine tumors	57.2	10	9285932 (1), 11795252 (1), 11476170 (1), 17043625 (1) (see all 7)
achlorhydria	54.6	10	16001675 (1), 7588006 (1), 20216072 (1), 2171816 (1) (see all 6)
ganglioneuroma	53.7	13	8354485 (3), 7576950 (3), 1300605 (1), 12739135 (1)
somatostatinoma	48.7	1	1974023 (1)
carcinoid	46.1	13	7935635 (3), 9426418 (1), 8266771 (1), 9189133 (1) (see all 9)
glucagonoma	45.4	2	12206598 (1), 8606627 (1)
ganglioneuroblastoma	44.1	1	12739135 (1)

Genetic Association Database (GAD): VIP
Human Genome Epidemiology (HuGE) Navigator: VIP (25 documents)

Export disorders for VIP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for VIP gene, integrated from 10 sources (see all 1493):
(articles sorted by number of sources associating them with VIP)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PubMed id 1318039)^{1, 2, 9} Kitamura K.... Eto T. (Biochem. Biophys. Res. Commun. 1992)
Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)^{1, 4} Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)^{1, 4} Saus E....Estivill X. (J Psychiatr Res 2010)
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (PubMed id 20554694)^{1, 4} Kovanen L....Partonen T. (Alcohol Alcohol. 2010)
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)^{1, 4} Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. (PubMed id 19470168)^{1, 4} Englund A....Partonen T. (J Circadian Rhythms 2009)
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)^{1, 4} GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)^{1, 4} Tremblay K....Laprise C. (PLoS ONE 2008)
Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation. (PubMed id 17448763)^{1, 4} Garcia-Barcelo M....Tam P.K. (J. Pediatr. Surg. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7432	HGNC: 12693	AceView: VIP	Ensembl:ENSG00000146469	euGenes: HUgn7432
ECgene: VIP	H-InvDB: VIP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for VIP	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Vasoactive_intestinal_peptide

Intellectual Property for VIP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for VIP gene:
Search GeneIP for patents involving VIP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	Regulatory tfbs in VIP promoter

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes VIP gene at Home site.

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VIP Gene

Vasoactive Intestinal Peptide

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Migraine
Pituitary Tumors
Erythroleukemia
Cystic Fibrosis
Dermatitis Atopic
Gastrinoma
Colitis Ulcerative
Somatostatinoma
Ischemia
Skin Diseases
Achlorhydria
Breast Cancer
Asthma
Adenocarcinoma
Cluster Headache
Ganglioneuroblastoma
Allergic rhinitis
cell damage
Hypertension Pulmonary
Hypochlorhydria
ADENOCARCINOMA GASTRIC
Biliary Fistula
Ovarian Cancer
COLON ADENOCARCINOMA
motility disorder
Epilepsy
endocrine neoplasm
PANCREAS EXOCRINE
Inflammation
Vipoma
Insulinoma
Psoriasis
Hypertrophy
aqueous humor
Rheumatoid Arthritis
prostate cancer
Tumors
Impotence
Mental Retardation
Pheochromocytoma
Autoimmunity
Rhinitis
pituitary adenoma nonfunctioning
achalasia
Islet Cell Tumor
Shock Septic
Cirrhosis
Autoimmune Diseases
Critically Ill
HYPERTENSION ARTERIAL
Colon Cancer
Hyperplasia
Hyperprolactinemia
inflammatory joint disease
PITUITARY ADENOMA
Rhinitis Vasomotor
Gulf War Syndrome
Multiple Endocrine Neoplasia
Hirschsprung Disease
Acromegaly
Erectile Dysfunction
neurodegeneration
WDHA syndrome
Shock Endotoxic
Sjogrens Syndrome
HEPATOCELLULAR CARCINOMA
Carcinoid
Glucagonoma
Pancreatic Cancer
Lymphoma Lymphoblastic
Bronchitis Chronic
small cell lung cancer
Inflammatory Bowel Diseases
HEART FAILURE
Carcinoma Adrenocortical
Neuroendocrine Tumors
Chronic Fatigue Syndrome
Heart Diseases
Pancreatic tumor
Ascites
Ganglioneuroma
MEGACOLON ACQUIRED
Congestion
Rhinitis Allergic Perennial
Histopathology
Autoimmune Response
Atrophy
STROKE
PANCREATIC CARCINOMA
Cholera
Hypokalemia
Dementia Multi-Infarct
Lupus Erythematosus Systemic
Arthritis

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VIP Gene

Vasoactive Intestinal Peptide

Aliasesfor VIP gene

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Genomic Variantsfor VIP gene

Disorders / Diseasesfor VIP gene

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for VIP gene

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