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Aliases for VIP Gene

Aliases for VIP Gene

  • Vasoactive Intestinal Peptide 2 3
  • Prepro-VIP 2 3
  • VIP Peptides 3
  • PHM27 3

External Ids for VIP Gene

Previous GeneCards Identifiers for VIP Gene

  • GC06P152633
  • GC06P152967
  • GC06P153103
  • GC06P153102
  • GC06P153164
  • GC06P150635

Summaries for VIP Gene

Entrez Gene Summary for VIP Gene

  • The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]

GeneCards Summary for VIP Gene

VIP (Vasoactive Intestinal Peptide) is a Protein Coding gene. Diseases associated with VIP include chemical colitis and dyshidrosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is ADCYAP1.

UniProtKB/Swiss-Prot for VIP Gene

  • VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

  • PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.

Tocris Summary for VIP Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival, regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIP Gene

Genomics for VIP Gene

Regulatory Elements for VIP Gene

Genomic Location for VIP Gene

Start:
152,750,376 bp from pter
End:
152,759,765 bp from pter
Size:
9,390 bases
Orientation:
Plus strand

Genomic View for VIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIP Gene

Proteins for VIP Gene

  • Protein details for VIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01282-VIP_HUMAN
    Recommended name:
    VIP peptides
    Protein Accession:
    P01282
    Secondary Accessions:
    • Q5TCY8
    • Q5TCY9
    • Q96QK3

    Protein attributes for VIP Gene

    Size:
    170 amino acids
    Molecular mass:
    19169 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIP Gene

    Alternative splice isoforms for VIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VIP Gene

Proteomics data for VIP Gene at MOPED

Post-translational modifications for VIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VIP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for VIP Gene

Domains for VIP Gene

Gene Families for VIP Gene

HGNC:

Protein Domains for VIP Gene

Suggested Antigen Peptide Sequences for VIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01282

UniProtKB/Swiss-Prot:

VIP_HUMAN :
  • P01282
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with VIP: view

Function for VIP Gene

Molecular function for VIP Gene

GENATLAS Biochemistry: precursor of vasoactive intestinal and PHM (intestinal peptide homolog of porcine PHI-27) peptide
UniProtKB/Swiss-Prot Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
UniProtKB/Swiss-Prot Function: PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.

Gene Ontology (GO) - Molecular Function for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005179 hormone activity IDA 9603988
GO:0005184 neuropeptide hormone activity TAS 10096039
GO:0005515 protein binding IPI 21314817
genes like me logo Genes that share ontologies with VIP: view
genes like me logo Genes that share phenotypes with VIP: view

Animal Models for VIP Gene

MGI Knock Outs for VIP:

Animal Model Products

CRISPR Products

miRNA for VIP Gene

miRTarBase miRNAs that target VIP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VIP Gene

Localization for VIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VIP Gene COMPARTMENTS Subcellular localization image for VIP gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with VIP: view

Pathways for VIP Gene

genes like me logo Genes that share pathways with VIP: view

Pathways by source for VIP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10096039
GO:0007589 body fluid secretion TAS 4035357
GO:0007611 learning or memory IEA --
GO:0008284 positive regulation of cell proliferation TAS 8389448
genes like me logo Genes that share ontologies with VIP: view

Compounds for VIP Gene

(5) Tocris Compounds for VIP Gene

Compound Action Cas Number
[Ala11,22,28]VIP Potent, highly selective VPAC1 agonist [291524-04-4]
[D-p-Cl-Phe6,Leu17]-VIP Selective VIP receptor antagonist [102805-45-8]
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation [40077-57-4]
Bay 55-9837 Potent and selective VPAC2 agonist [463930-25-8]
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP [118025-43-7]

(148) Novoseek inferred chemical compound relationships for VIP Gene

Compound -log(P) Hits PubMed IDs
adenylate 87.2 155
pacap 38 81.8 42
pacaps 77 10
viphyb 74.8 2
forskolin 71.5 96
genes like me logo Genes that share compounds with VIP: view

Transcripts for VIP Gene

Unigene Clusters for VIP Gene

Vasoactive intestinal peptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VIP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for VIP Gene

GeneLoc Exon Structure for
VIP
ECgene alternative splicing isoforms for
VIP

Expression for VIP Gene

mRNA expression in normal human tissues for VIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIP Gene

This gene is overexpressed in Colon - Sigmoid (11.2) and Esophagus - Muscularis (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VIP Gene

SOURCE GeneReport for Unigene cluster for VIP Gene Hs.53973

genes like me logo Genes that share expressions with VIP: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for VIP Gene

Orthologs for VIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VIP 35
  • 99.41 (n)
  • 100 (a)
VIP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VIP 35
  • 87.06 (n)
  • 86.47 (a)
VIP 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VIP 35
  • 88.04 (n)
  • 86.47 (a)
VIP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vip 35
  • 80.59 (n)
  • 79.41 (a)
Vip 16
Vip 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VIP 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VIP 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vip 35
  • 82.75 (n)
  • 82.35 (a)
chicken
(Gallus gallus)
Aves VIP 35
  • 71.13 (n)
  • 64.57 (a)
VIP 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VIP 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia vip-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia vip 35
  • 70.87 (n)
  • 72.44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14201 35
zebrafish
(Danio rerio)
Actinopterygii vip 35
  • 66.67 (n)
  • 71.11 (a)
vip 36
  • 49 (a)
OneToOne
Species with no ortholog for VIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIP Gene

ENSEMBL:
Gene Tree for VIP (if available)
TreeFam:
Gene Tree for VIP (if available)

Paralogs for VIP Gene

Paralogs for VIP Gene

Selected SIMAP similar genes for VIP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VIP: view

Variants for VIP Gene

Sequence variations from dbSNP and Humsavar for VIP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs688136 -- 152,758,926(+) GAAAA(C/T)GATAC utr-variant-3-prime
rs1321967 -- 152,759,055(+) TGTGA(A/T)GTTTA utr-variant-3-prime
rs1321968 -- 152,759,102(+) TTTAA(A/C)TCATA utr-variant-3-prime
rs1407264 -- 152,757,815(+) TTTTT(C/T)TTTGT intron-variant
rs1407267 -- 152,749,316(+) CATTT(G/T)TCTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VIP Gene

Variant ID Type Subtype PubMed ID
dgv2017e1 CNV Complex 17122850

Relevant External Links for VIP Gene

HapMap Linkage Disequilibrium report
VIP
Human Gene Mutation Database (HGMD)
VIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIP Gene

Disorders for VIP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (30) Diseases for VIP Gene including...

Search for VIP Gene in MalaCards »

(94) Novoseek inferred disease relationships for VIP Gene

Disease -log(P) Hits PubMed IDs
wdha syndrome 80.2 11
vipoma 78 14
megacolon acquired 66.6 6
neuroendocrine tumors 57.2 7
achlorhydria 54.6 6

Relevant External Links for VIP

Genetic Association Database (GAD)
VIP
Human Genome Epidemiology (HuGE) Navigator
VIP
genes like me logo Genes that share disorders with VIP: view

No data available for UniProtKB/Swiss-Prot for VIP Gene

Publications for VIP Gene

  1. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP-27, but not PACAP-38) degradation by the neutral endopeptidase EC 3.4.24.11. (PMID: 9313778) Gourlet P. … Deschodt-Lanckman M. (Biochem. Pharmacol. 1997) 3 23
  2. Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide. (PMID: 10801840) Nicole P. … Laburthe M. (J. Biol. Chem. 2000) 3 23
  3. VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death. (PMID: 10446313) Brenneman D.E. … Ruff M. (Brain Res. 1999) 3 23
  4. Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. (PMID: 11884208) Strauss G.I. … Knudsen G.M. (Neuropeptides 2001) 3 23
  5. Suppression of tumorigenicity in neuroblastoma cells by upregulation of human vasoactive intestinal peptide receptor type 1. (PMID: 12409228) Balster D.A. … Qualman S.J. (Regul. Pept. 2002) 3 23

Products for VIP Gene

  • Addgene plasmids for VIP

Sources for VIP Gene

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