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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VIP Gene

protein-coding GIFtS: 63
GCID: GC06P153164

vasoactive intestinal peptide

Explore 169 diseases affiliated with
VIP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Vasoactive Intestinal Peptide¹ ²
PHM27²
VIP Peptides²

External Ids:	HGNC: 12693¹	Entrez Gene: 7432²	Ensembl: ENSG00000146469⁷	OMIM: 192320⁵	UniProtKB: P01282³

Export aliases for VIP gene to outside databases

Previous GC identifers: GC06P152633 GC06P152967 GC06P153103 GC06P153102 GC06P150635

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VIP:

The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes

vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea,

stomach and gall bladder. Alternative splicing occurs at this locus and two transcript variants encoding distinct

isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282

Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases

glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder

Function: PHM and PHV also cause vasodilation

summary for VIP:

Vasoactive intestinal peptide (VIP) receptors are a group of Gs-protein-coupled receptors that are currently

divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous

system and are also found in peripheral organs including the liver, lung, intestine, skeletal muscle, heart

and kidney. VPAC1 and VPAC2 have diverse biological actions including promotion of neuronal survival,

regulation of glycogen metabolism, stimulation of prolactin release from the pituitary and catecholamine

release from the adrenal medulla, and inhibition of IL-2-mediated T-cell proliferation. The human genes

encoding VPAC1 and VPAC2 receptor have been located on chromosomes 3p22 and 7q36.3 respectively.

Gene Wiki entry for VIP (Vasoactive intestinal peptide)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VIP gene promoter:
STAT1 AP-1 NRSF form 1 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VIP promoter sequence

Search SABiosciences Chromatin IP Primers for VIP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VIP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q24-q27

VIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIP gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P153164: view genomic region (about GC identifiers)

Start:	153,071,933 bp from pter	End:	153,080,900 bp from pter
Size:	8,968 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282 (See protein sequence)

Recommended Name: VIP peptides precursor

Size: 170 amino acids; 19169 Da

Subcellular location: Secreted

2 PDB 3D structures from and Proteopedia for VIP:

2RRH (3D)

2RRI (3D)

Secondary accessions: Q5TCY8 Q5TCY9 Q96QK3

Alternative splicing: 2 isoforms: P01282-1 P01282-2

Explore the universe of human proteins at neXtProt for VIP: NX_P01282

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01282

VIP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_003372.1 NP_919416.1

ENSEMBL proteins:

ENSP00000356213 ENSP00000356212 ENSP00000410356

Reactome Protein details: P01282
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): VIP OriGene Custom Protein Services for VIP
	GenScript Custom Purified and Recombinant Proteins Services for VIP
	Novus Biologicals VIP Protein Novus Biologicals VIP Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VIP

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0043025	neuronal cell body	IEA	--

VIP for ontologies About GeneDecksing

VIP Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of VIP
	R&D Systems Antibodies for VIP
	OriGene Antibodies: VIP OriGene Custom Antibody Services for VIP
	GenScript Custom Superior Antibodies Services for VIP
	Novus Biologicals VIP Antibodies
	Abcam antibodies for VIP
	Uscn Antibodies for VIP
	ThermoFisher Antibodies for VIP

Assay Products for VIP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VIP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VIP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VIP for domains About GeneDecksing

2 InterPro domains/families:

IPR015523 VIP

IPR000532 Glucagon_GIP_secretin_VIP

Graphical View of Domain Structure for InterPro Entry P01282

ProtoNet protein and cluster: P01282

1 Blocks protein family: IPB000532 Glucagon/GIP/secretin/VIP

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282

Similarity: Belongs to the glucagon family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VIP_HUMAN, P01282

Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases

glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder

Function: PHM and PHV also cause vasodilation

Genatlas biochemistry entry for VIP:

precursor of vasoactive intestinal and PHM (intestinal peptide homolog of porcine PHI-27) peptide

miRNA Products:		OriGene 3'-UTR Clone (see all 2): VIP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIP
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate VIP (see all 18):
		hsa-miR-30c hsa-miR-30d hsa-miR-373* hsa-miR-183* hsa-miR-30a hsa-miR-3148 hsa-miR-556-3p hsa-miR-205

		SwitchGear 3'UTR luciferase reporter plasmid: VIP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VIP (see all 7) OriGene shRNA RFP: VIP OriGene siRNA: VIP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for VIP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VIP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VIP (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): VIP (NM_194435)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VIP
		Search LifeMap BioReagents cell lines for VIP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IDA	9603988
GO:0005184	neuropeptide hormone activity	TAS	10096039

VIP for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Vip^tm1Clw for VIP
     5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vip):

behavior/neurological

endocrine/exocrine gland

homeostasis/metabolism

normal

reproductive system

VIP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G beta:gamma signalling through PLC beta

G alpha (s) signalling events

0.14

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for VIP

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	G alpha (s) signalling events

VIP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VIP

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for VIP (P01282^{2, 3} ENSP00000356213⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²^,³, ENSP00000353731⁴	MINT-8090811 MINT-8090848 I2D: score=1 STRING: ENSP00000353731
FAP	Q12884²^,³, ENSP00000188790⁴	MINT-8090577 MINT-8094195 I2D: score=1 STRING: ENSP00000188790
MEOX2	P50222²^,³, ENSP00000262041⁴	MINT-68122 I2D: score=5 STRING: ENSP00000262041
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2864067 I2D: score=3 STRING: ENSP00000357292
MME	P08473³, ENSP00000353679⁴	I2D: score=1 STRING: ENSP00000353679

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	10096039
GO:0007589	body fluid secretion	TAS	4035357
GO:0007611	learning or memory	IEA	--
GO:0008284	positive regulation of cell proliferation	TAS	8389448

VIP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

VIP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for VIP available from Tocris Bioscience About this table

Compound	Action	CAS #
[Ala11,22,28]VIP	Potent, highly selective VPAC1 agonist	[291524-04-4]
Bay 55-9837	Potent and selective VPAC2 agonist	[463930-25-8]
VIP (6-28) (human, rat, porcine, bovine)	VIP antagonist	[69698-54-0]
VIP (human, rat, mouse, rabbit, canine, porcine)	Involved in neurotransmission, smooth muscle relaxation	[40077-57-4]
PHM 27 (human)	Potent calcitonin receptor agonist; endogenous analog of human VIP	[118025-43-7]

10/148 Novoseek chemical compound relationships for VIP gene (see all 148) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenylate	87.2	481	2167366 (4), 9418704 (4), 8698838 (3), 7623776 (3) (see all 99)
pacap 38	81.8	55	9002987 (5), 12147212 (5), 7623776 (4), 7910101 (3) (see all 22)
pacaps	77	17	8698838 (3), 10578152 (1), 8752138 (1), 20043043 (1) (see all 8)
viphyb	74.8	2	11859929 (1), 10670826 (1)
forskolin	71.5	127	11165399 (4), 19026713 (3), 1371513 (3), 11678758 (3) (see all 72)
cyclic amp	70.6	144	1384276 (5), 9789791 (5), 7741049 (4), 15800375 (4) (see all 59)
helospectin i	68.8	9	8680719 (3), 15003357 (3), 1847591 (1)
d-ala(1)-peptide t amide	66.9	5	7575755 (1), 10446313 (1)
helospectin	66.5	6	8680719 (1), 1438980 (1), 9928018 (1), 10880980 (1)
spantide	62.6	2	7679135 (1)

Search CenterWatch for drugs/clinical trials and news about VIP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VIP gene (2 alternative transcripts):

NM_003381.3 NM_194435.2

Unigene Cluster for VIP:

Vasoactive intestinal peptide

Hs.53973 [show with all ESTs]

Unigene Representative Sequence: NM_003381

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367244(uc003qpe.3) ENST00000367243(uc003qpf.3 uc010kjd.3)

ENST00000431366

miRNA Products:		OriGene 3'-UTR Clone (see all 2): VIP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIP
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate VIP (see all 18):
		hsa-miR-30c hsa-miR-30d hsa-miR-373* hsa-miR-183* hsa-miR-30a hsa-miR-3148 hsa-miR-556-3p hsa-miR-205

		SwitchGear 3'UTR luciferase reporter plasmid: VIP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VIP (see all 7) OriGene shRNA RFP: VIP OriGene siRNA: VIP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VIP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VIP (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): VIP (NM_194435)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VIP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat VIP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIP

Additional cDNA sequence:

AK291959.1 AK313950.1 BC009794.1 M36634.1 M54930.1

1 DOTS entry:

DT.109681

21 AceView cDNA sequences:

NM_003381 BX092558 CR593090 BQ723487 NM_194435 AU105582 AU099390 BF445774

AL533330 BM971673 BC009794 BQ720510 BQ900960 AI217172 AL533286 M36634

BG199555 BF679063 BF668372 AW779139 M54930

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for VIP About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:					-
SP2:					-
SP3:
SP4:

ECgene alternative splicing isoforms for VIP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

VIP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Glomerulus

Kidney

Metanephros

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See VIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VIP

SOURCE GeneReport for Unigene cluster: Hs.53973

SABiosciences Expression via Pathway-Focused PCR Array including VIP:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VIP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat VIP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for VIP gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Vip^{1 , 5}	vasoactive intestinal polypeptide^{1, 5}	80.59(n)¹ 79.41(a)¹		10 (1.97 cM)⁵ 22353¹ NM_011702.2¹ NP_035832.1¹ 5639218⁵
chicken (Gallus gallus)	Aves	VIP¹	vasoactive intestinal peptide	67.3(n) 59.49(a)		396323 NM_205366.2 NP_990697.2
lizard (Anolis carolinensis)	Reptilia	VIP⁶	--	46(a)	1 ↔ 1	1(215969643-215975974)
African clawed frog (Xenopus laevis)	Amphibia	vip-A²	vasoactive intestinal peptide	76.96(n)		BC043792.1
zebrafish (Danio rerio)	Actinopterygii	vip¹	vasoactive intestinal peptide	66.67(n) 71.11(a)		795653 NM_001114553.1 NP_001108025.1

ENSEMBL Gene Tree for VIP (if available)
TreeFam Gene Tree for VIP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VIP gene

ADCYAP1²

1 SIMAP similar gene for VIP using alignment to 2 protein entries: VIP_HUMAN (see all proteins):

ADCYAP1

VIP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147142813^1,2		--	153070005(+)	`CAGGA-/TAAATT TGACT`	2	--	us2k¹		0	--	--	--	--
rs187465019^1,2		--	153070053(+)	`AAGCAC/TCCAAA`	2	--	us2k¹		0	--	--	--	--
rs191868685^1,2		--	153070069(+)	`AGCTGA/GCTACA`	2	--	us2k¹		0	--	--	--	--
rs142011609^1,2		--	153070163(+)	`ACCTGA/CAGATG`	2	--	us2k¹		0	--	--	--	--
rs115068509^1,2	F,	--	153070186(+)	`CATTTT/GCAAAT`	2	--	us2k¹		1		WA	118
rs12212849^1,2	C,F,H,	--	153070203(+)	`GCTTTC/GTAGTT`	2	--	us2k¹		13		NS EA WA CSA NA	1202
rs182964045^1,2		--	153070212(+)	`TTTAAA/TTTCAT`	2	--	us2k¹		0	--	--	--	--
rs145865991^1,2		--	153070350(+)	`CTATAA/GTTACT`	2	--	us2k¹		0	--	--	--	--
rs1407267^1,2	C,F,O,A,H,	--	153070451(+)	`CATTTG/TTCTGT`	2	--	us2k¹		22		EA NA NS WA	1896
rs185892857^1,2		--	153070511(+)	`TCACTA/GAGAAT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VIP (153071933 - 153080900 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for VIP
1 CNV: 3645
Human Gene Mutation Database (HGMD): VIP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VIP

DNA2.0 Custom Variant and Variant Library Synthesis for VIP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VIP for disorders           About GeneDecksing

OMIM gene information: 192320    OMIM disorders: --

20/169 diseases for VIP (see all 169):    About MalaCards

subcortical arteriosclerotic encephalopathy von hippel-lindau disease normal pressure hydrocephalus cluster headache

islet cell tumor multiple endocrine neoplasia refractive error wdha syndrome

multiple chemical sensitivity vasomotor rhinitis chronic fatigue syndrome growth hormone deficiency

somatostatinoma pancreatic islet cell tumors vipoma primitive neuroectodermal tumor

allergic rhinitis pituitary adenoma rhinitis megacolon

10 diseases from the University of Copenhagen DISEASES database for VIP:

Diarrhea Cholera Pancreatic cholera Ganglioneuroma

Neuroendocrine tumor Neuroblastoma Hypokalemia Asthma

Hirschsprung's disease Constipation

10/94 Novoseek disease relationships for VIP gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wdha syndrome	80.2	17	2153088 (3), 15051093 (2), 19184565 (1), 11762360 (1) (see all 8)
vipoma	78	26	19184565 (2), 8383153 (2), 16001675 (1), 7588006 (1) (see all 12)
megacolon acquired	66.6	6	8689918 (3), 7506433 (2), 10859084 (1)
neuroendocrine tumors	57.2	10	9285932 (1), 11795252 (1), 11476170 (1), 17043625 (1) (see all 7)
achlorhydria	54.6	10	16001675 (1), 7588006 (1), 20216072 (1), 2171816 (1) (see all 6)
ganglioneuroma	53.7	13	8354485 (3), 7576950 (3), 1300605 (1), 12739135 (1)
somatostatinoma	48.7	1	1974023 (1)
carcinoid	46.1	13	7935635 (3), 9426418 (1), 8266771 (1), 9189133 (1) (see all 9)
glucagonoma	45.4	2	12206598 (1), 8606627 (1)
ganglioneuroblastoma	44.1	1	12739135 (1)

Human Genome Epidemiology (HuGE) Navigator: VIP (25 documents)

Export disorders for VIP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VIP gene, integrated from 9 sources (see all 1484):
(articles sorted by number of sources associating them with VIP)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PubMed id 1318039)^{1, 2, 9} Kitamura K.... Eto T. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Structural determination of the vasoactive intestinal peptide by two- dimensional H-NMR spectroscopy. (PubMed id 1863695)^{1, 2} Theriault Y.... St Pierre S. (1991)
Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter. (PubMed id 2839091)^{1, 2} Yamagami T.... Okamoto H. (1988)
Structure and expression of the gene encoding the vasoactive intestinal peptide precursor. (PubMed id 3025882)^{1, 2} Linder S.... Magnusson G. (1987)
Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide- derived peptide. (PubMed id 3654650)^{1, 2} Yiangou Y....Bloom S.R. (1987)
Vasoactive intestinal peptide gene: putative mechanism of information storage at the RNA level. (PubMed id 2434617)^{1, 2} Gozes I.... Shani Y. (1987)
Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor. (PubMed id 3748844)^{1, 2} Gozes I.... Fridkin M. (1986)
Vasoactive intestinal peptide: expression of the prohormone in bacterial cells. (PubMed id 2995945)^{1, 2} Delamarter J.F.... Bloom S.R. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7432	HGNC: 12693	AceView: VIP	Ensembl:ENSG00000146469	euGenes: HUgn7432
ECgene: VIP	H-InvDB: VIP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VIP	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Vasoactive_intestinal_peptide

Intellectual Property for VIP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for VIP gene:
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GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ThermoFisher Antibodies for VIP

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Migraine
Pituitary Tumors
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Cystic Fibrosis
Dermatitis Atopic
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Colitis Ulcerative
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Achlorhydria
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motility disorder
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Inflammation
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aqueous humor
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prostate cancer
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HYPERTENSION ARTERIAL
Colon Cancer
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inflammatory joint disease
PITUITARY ADENOMA
Rhinitis Vasomotor
Gulf War Syndrome
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neurodegeneration
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MEGACOLON ACQUIRED
Congestion
Rhinitis Allergic Perennial
Histopathology
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PANCREATIC CARCINOMA
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vasoactive intestinal peptide

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