Aliases for VIP Gene
External Ids for VIP Gene
- HGNC: 12693
- Entrez Gene: 7432
- Ensembl: ENSG00000146469
- OMIM: 192320
- UniProtKB: P01282
Previous GeneCards Identifiers for VIP Gene
- GC06P152633
- GC06P152967
- GC06P153103
- GC06P153102
- GC06P153164
- GC06P150635
Summaries for VIP Gene
-
The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]
GeneCards Summary for VIP Gene
VIP (Vasoactive Intestinal Peptide) is a Protein Coding gene. Diseases associated with VIP include Vipoma and Wdha Syndrome. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. Gene Ontology (GO) annotations related to this gene include receptor binding and neuropeptide hormone activity. An important paralog of this gene is ADCYAP1.
UniProtKB/Swiss-Prot for VIP Gene
-
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
-
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
-
Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.
Additional gene information for VIP Gene
- Monarch Initiative
- Search for VIP at DataMed
- Search for VIP at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIP Gene
Genomics for VIP Gene
GeneHancer (GH) Regulatory Elements for VIP Gene
Promoters and enhancers for VIP Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06I152750 | Promoter | 0.9 | EPDnew | 550.8 | +2.9 | 2855 | 0.1 | KLF6 SIN3A MIER2 REST DNMT3B MBD1 CREB1 ZNF143 RCOR1 | VIP GC06P152764 | |
| GH06I152746 | Enhancer | 0.7 | ENCODE | 550.8 | -1.6 | -1602 | 0.2 | SOX13 FOXA2 SAP130 JUN CEBPG ZNF644 RFX5 POLR2A FOSL2 FOS | VIP HSPD1P16 MYCT1 | |
| GH06I152694 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE dbSUPER | 8.1 | -48.9 | -48918 | 8.2 | CTCF SRF ZNF654 TAF1 JUN REST RAD21 NR2F2 JUND POLR2A | MYCT1 VIP HSPD1P16 | |
| GH06I152575 | Enhancer | 0.9 | Ensembl ENCODE | 9.4 | -172.0 | -172022 | 1 | CEBPG FEZF1 ZEB1 HIC1 ZNF366 ZNF362 ZNF189 HLF CEBPB ZEB2 | SYNE1 VIP NANOGP11 | |
| GH06I153024 | Enhancer | 0.7 | ENCODE | 9.7 | +276.7 | 276688 | 0.2 | CTCF PKNOX1 ATF1 ETV1 RAD21 TEAD3 ZNF143 SMC3 MIXL1 SRF | PIR48130 VIP MTRF1L RGS17 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around VIP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the VIP gene promoter:
Regulatory Element Products
Genomic Locations for VIP Gene
Genomic Locations for VIP Gene
- chr6:152,747,923-152,759,765
- (GRCh38/hg38)
- Size:
- 11,843 bases
- Orientation:
- Plus strand
- chr6:153,071,933-153,080,900
- (GRCh37/hg19)
Genomic View for VIP Gene
Genes around VIP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q25.2 by Ensembl
- 6q25.2 by Entrez Gene
- 6q25.2 by HGNC
VIP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for VIP Gene
Proteins for VIP Gene
-
Protein details for VIP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01282-VIP_HUMAN
- Recommended name:
- VIP peptides
- Protein Accession:
- P01282
- Q5TCY8
- Q5TCY9
- Q96QK3
Protein attributes for VIP Gene
- Size:
- 170 amino acids
- Molecular mass:
- 19169 Da
- Quaternary structure:
- No Data Available
Protein Expression for VIP Gene
Post-translational modifications for VIP Gene
No Post-translational modifications
Other Protein References for VIP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for VIP (VIP)
- Cell Signaling Technology (CST) Antibodies for VIP (VIP)
- Novus Biologicals Antibodies for VIP
-
Abcam antibodies for VIP
-
Cloud-Clone Corp. Antibodies for VIP
- Invitrogen Antibodies for VIP
- antibodies-online: Search results for 148 available VIP Antibodies ranked by validation data
- Compare Top VIP Antibodies
-
Recommended
- 71 WB Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 21 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-rat)
- 10 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 40 WB Antibodies (anti-rat)
- 2 IF Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 71 WB Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 21 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-rat)
- 10 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 40 WB Antibodies (anti-rat)
- 2 IF Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- GeneTex VIP antibody for VIP
-
Santa Cruz Biotechnology (SCBT) Antibodies for VIP
Protein Products
- R&D Systems Peptides for VIP
-
OriGene Purified Proteins for VIP
- Search Origene for MassSpec and Protein Over-expression Lysates for VIP
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- Sino Biological Cell Lysates for VIP
-
Cloud-Clone Corp. Proteins for VIP
- Search GeneTex for Proteins for VIP
-
ProSci Proteins for VIP
-
Abcam proteins for VIP
Assay Products
-
Cloud-Clone Corp. Assay Kits for VIP
- antibodies-online: Search results for 87 available VIP Elisa Kits ranked by validation data
- Compare Top VIP Elisa Kits
-
Recommended
- 6 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 4 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 6 Guinea Pig ELISA Kits
- 21 Human ELISA Kits
- 2 Monkey ELISA Kits
- 19 Mouse (Murine) ELISA Kits
- 9 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 20 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 6 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 4 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 6 Guinea Pig ELISA Kits
- 21 Human ELISA Kits
- 2 Monkey ELISA Kits
- 19 Mouse (Murine) ELISA Kits
- 9 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 20 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
No data available for DME Specific Peptides for VIP Gene
Domains & Families for VIP Gene
Gene Families for VIP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for VIP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for VIP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P01282- Family:
-
- Belongs to the glucagon family.
Function for VIP Gene
Molecular function for VIP Gene
- GENATLAS Biochemistry:
- precursor of vasoactive intestinal and PHM (intestinal peptide homolog of porcine PHI-27) peptide
- UniProtKB/Swiss-Prot Function:
- VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
- UniProtKB/Swiss-Prot Function:
- PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
Phenotypes From GWAS Catalog for VIP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005179 | hormone activity | IDA | 9603988 |
| GO:0005184 | neuropeptide hormone activity | TAS | 10096039 |
| GO:0005515 | protein binding | IPI | 21314817 |
Phenotypes for VIP Gene
- MGI mutant phenotypes for VIP:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for VIP:
Animal Models for VIP Gene
- MGI Knock Outs for VIP:
-
- Vip tm1Clw
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for VIP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for VIP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VIP gene
- Search ViGene Biosciences for VIP
CRISPR Products
-
OriGene CRISPR knockouts for VIP
- genomics-online: gRNA clones - Search results for available Vip gene related products
- Applied Biological Materials CRISPR for VIP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VIP
- GenScript: Design CRISPR guide RNA sequences for VIP
miRNA for VIP Gene
- miRTarBase miRNAs that target VIP
miRNA Products
- Search ViGene Biosciences for VIP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for VIP
- Browse OriGene Inhibitory RNA Products For VIP
- genomics-online: shRNA clones - Search results for available Vip gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VIP gene
Clone Products
- Sino Biological Human cDNA Clone for VIP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VIP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for VIP
- genomics-online: cdna clones - Search results for available Vip gene related products
- orf clones - Search results for available Vip gene related products
- Applied Biological Materials Clones for VIP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for VIP
-
ViGene Biosciences adenoviral particle packaged cDNA for VIP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for VIP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for VIP gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VIP Gene
Localization for VIP Gene
Subcellular locations from UniProtKB/Swiss-Prot for VIP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005622 | intracellular | IEA | -- |
Pathways & Interactions for VIP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Neuroscience | ||
| 3 | G alpha (s) signalling events | ||
| 4 | Gastric acid production | ||
| 5 | IL-6 signaling pathway | ||
Pathways by source for VIP Gene
1 Cell Signaling Technology pathway for VIP Gene
2 BioSystems pathways for VIP Gene
4 Reactome pathways for VIP Gene
Interacting Proteins for VIP Gene
Selected Interacting proteins:
ENSP00000356213
P01282-VIP_HUMAN
for VIP Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | IDA | 9603988 |
| GO:0007589 | body fluid secretion | TAS | 4035357 |
| GO:0008284 | positive regulation of cell proliferation | TAS | 8389448 |
| GO:0010469 | regulation of receptor activity | IEA | -- |
Drugs & Compounds for VIP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Histamine | Approved, Investigational | Pharma | Full agonist, Agonist | 1105 | ||
| Sumatriptan | Approved, Investigational | Pharma | Full agonist, Agonist | 5-HT1 receptor agonist | 123 | |
| Almotriptan | Approved, Investigational | Pharma | 13 | |||
| Ephedrine | Approved | Pharma | Partial agonist, Agonist | 664 | ||
| Pseudoephedrine | Approved | Pharma | 666 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| VIP (human, rat, mouse, rabbit, canine, porcine) |
|
40077-57-4 |
|
|
(5) Tocris Compounds for VIP Gene
| Compound | Action | Cas Number |
|---|---|---|
| [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) | VIP receptor antagonist | 93965-89-0 |
| [Ala11,22,28]VIP | Potent, highly selective VPAC1 agonist | 291524-04-4 |
| Bay 55-9837 | Potent and selective VPAC2 agonist | 463930-25-8 |
| VIP (guinea pig) | Involved in neurotransmission and smooth muscle relaxation | 96886-24-7 |
| VIP (human, rat, mouse, rabbit, canine, porcine) | Involved in neurotransmission and smooth muscle relaxation | 40077-57-4 |
Transcripts for VIP Gene
mRNA/cDNA for VIP Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for VIP Gene
CRISPR Products
-
OriGene CRISPR knockouts for VIP
- genomics-online: gRNA clones - Search results for available Vip gene related products
- Applied Biological Materials CRISPR for VIP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for VIP
- GenScript: Design CRISPR guide RNA sequences for VIP
miRNA Products
- Search ViGene Biosciences for VIP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for VIP
- Browse OriGene Inhibitory RNA Products For VIP
- genomics-online: shRNA clones - Search results for available Vip gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for VIP gene
Clone Products
- Sino Biological Human cDNA Clone for VIP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for VIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for VIP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for VIP
- genomics-online: cdna clones - Search results for available Vip gene related products
- orf clones - Search results for available Vip gene related products
- Applied Biological Materials Clones for VIP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: |
Expression for VIP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Cerebellum
- Midbrain tegmentum
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Neurons
- Adult Dopaminergic Neurons Ventral Tegmental Area
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for VIP Gene
This gene is overexpressed in Colon - Sigmoid (x11.2) and Esophagus - Muscularis (x4.0).
This gene is overexpressed in Colon muscle (39.1) and Colon (11.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VIP Gene
NURSA nuclear receptor signaling pathways regulating expression of VIP Gene:
VIPSOURCE GeneReport for Unigene cluster for VIP Gene:
Hs.53973Evidence on tissue expression from TISSUES for VIP Gene
- Intestine(3.7)
- Nervous system(3.7)
- Pancreas(3.6)
- Muscle(3.1)
- Stomach(2.7)
- Adrenal gland(2.6)
- Gall bladder(2.6)
- Blood(2.5)
- Heart(2.5)
- Liver(2.3)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs for VIP
-
OriGene qPCR primer pairs and template standards for VIP
- genomics-online: primer clones - Search results for available Vip gene related products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for VIP Gene
Orthologs for VIP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | VIP 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | VIP 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | VIP 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Vip 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Vip 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | VIP 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | VIP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | VIP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | VIP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | vip 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | vip-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | vip 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.14201 33 |
|
- Species where no ortholog for VIP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for VIP Gene
Variants for VIP Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000042723 | -- | 152,747,349(+) | A/G | upstream_transcript_variant | |
| rs1000049427 | -- | 152,753,681(+) | G/C | intron_variant | |
| rs1000088022 | -- | 152,747,207(+) | T/C | upstream_transcript_variant | |
| rs1000112823 | -- | 152,755,977(+) | T/A | intron_variant | |
| rs1000185359 | -- | 152,755,692(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759478 | CNV | loss | 17122850 |
Residual Variation Intolerance Score:
48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.62;
13.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for VIP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIP Gene
Disorders for VIP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vipoma |
|
|
| wdha syndrome |
|
|
| vasomotor rhinitis |
|
|
| ganglioneuroma |
|
|
| chemical colitis |
|
|
Search VIP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for VIP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for VIP Gene
Publications for VIP Gene
- Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
- Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (PMID: 20554694) Kovanen L … Partonen T (Alcohol and alcoholism (Oxford, Oxfordshire) 2010) 3 44 58
- Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 44 58
- Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V … Urretavizcaya M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 44 58
- Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation. (PMID: 20007697) Tee AE … Liu T (The Journal of biological chemistry 2010) 3 22 58
Products for VIP Gene
- R&D Systems Antibodies for VIP (VIP)
- R&D Systems Peptides for VIP
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
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- Custom Antibody ServicesOriGene Antibodies for VIP
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for VIP
- Design optimal peptide antigens
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- antibodies-online: Search results for 148 available VIP Antibodies ranked by validation data
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