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Aliases for VIP Gene

Aliases for VIP Gene

  • Vasoactive Intestinal Peptide 2 3 5
  • Prepro-VIP 2 3
  • PHM27 3

External Ids for VIP Gene

Previous GeneCards Identifiers for VIP Gene

  • GC06P152633
  • GC06P152967
  • GC06P153103
  • GC06P153102
  • GC06P153164
  • GC06P150635

Summaries for VIP Gene

Entrez Gene Summary for VIP Gene

  • The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]

GeneCards Summary for VIP Gene

VIP (Vasoactive Intestinal Peptide) is a Protein Coding gene. Diseases associated with VIP include Vipoma and Wdha Syndrome. Among its related pathways are Signaling by GPCR and G alpha (s) signalling events. GO annotations related to this gene include receptor binding and neuropeptide hormone activity. An important paralog of this gene is ADCYAP1.

UniProtKB/Swiss-Prot for VIP Gene

  • VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

  • PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.

Tocris Summary for VIP Gene

  • Vasoactive intestinal peptide (VIP) receptors are a group of Gs -protein-coupled receptors that are currently divided into two subtypes; VPAC1 and VPAC2. They are widely distributed throughout the central nervous system.

Gene Wiki entry for VIP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIP Gene

Genomics for VIP Gene

Regulatory Elements for VIP Gene

Enhancers for VIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VIP on UCSC Golden Path with GeneCards custom track

Genomic Location for VIP Gene

Chromosome:
6
Start:
152,747,923 bp from pter
End:
152,759,765 bp from pter
Size:
11,843 bases
Orientation:
Plus strand

Genomic View for VIP Gene

Genes around VIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIP Gene

Proteins for VIP Gene

  • Protein details for VIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01282-VIP_HUMAN
    Recommended name:
    VIP peptides
    Protein Accession:
    P01282
    Secondary Accessions:
    • Q5TCY8
    • Q5TCY9
    • Q96QK3

    Protein attributes for VIP Gene

    Size:
    170 amino acids
    Molecular mass:
    19169 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for VIP Gene

    Alternative splice isoforms for VIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VIP Gene

Proteomics data for VIP Gene at MOPED

Post-translational modifications for VIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VIP Gene

No data available for DME Specific Peptides for VIP Gene

Domains & Families for VIP Gene

Gene Families for VIP Gene

Protein Domains for VIP Gene

Suggested Antigen Peptide Sequences for VIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01282

UniProtKB/Swiss-Prot:

VIP_HUMAN :
  • Belongs to the glucagon family.
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with VIP: view

Function for VIP Gene

Molecular function for VIP Gene

GENATLAS Biochemistry:
precursor of vasoactive intestinal and PHM (intestinal peptide homolog of porcine PHI-27) peptide
UniProtKB/Swiss-Prot Function:
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
UniProtKB/Swiss-Prot Function:
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.

Gene Ontology (GO) - Molecular Function for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with VIP: view
genes like me logo Genes that share phenotypes with VIP: view

Animal Models for VIP Gene

MGI Knock Outs for VIP:

Animal Model Products

miRNA for VIP Gene

miRTarBase miRNAs that target VIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VIP Gene

Localization for VIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VIP Gene COMPARTMENTS Subcellular localization image for VIP gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with VIP: view

Pathways & Interactions for VIP Gene

genes like me logo Genes that share pathways with VIP: view

Pathways by source for VIP Gene

SIGNOR curated interactions for VIP Gene

Activates:

Gene Ontology (GO) - Biological Process for VIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IDA 18603306
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10096039
GO:0007589 body fluid secretion TAS 4035357
GO:0007611 learning or memory IEA --
genes like me logo Genes that share ontologies with VIP: view

Drugs & Compounds for VIP Gene

(107) Drugs for VIP Gene - From: ClinicalTrials, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist 97
Almotriptan Approved, Investigational Pharma 13
Ephedrine Approved Pharma Partial agonist, Agonist 548
Histamine Phosphate Approved Pharma 998
Pseudoephedrine Approved Pharma 548

(67) Additional Compounds for VIP Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Ala11,22,28]VIP
291524-04-4
PHM 27 (human)
118025-43-7
VIP (guinea pig)
96886-24-7
VIP (human, rat, mouse, rabbit, canine, porcine)
40077-57-4

(5) Tocris Compounds for VIP Gene

Compound Action Cas Number
[Ala11,22,28]VIP Potent, highly selective VPAC1 agonist 291524-04-4
Bay 55-9837 Potent and selective VPAC2 agonist 463930-25-8
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
VIP (guinea pig) Involved in neurotransmission and smooth muscle relaxation 96886-24-7
VIP (human, rat, mouse, rabbit, canine, porcine) Involved in neurotransmission and smooth muscle relaxation 40077-57-4
genes like me logo Genes that share compounds with VIP: view

Transcripts for VIP Gene

mRNA/cDNA for VIP Gene

Unigene Clusters for VIP Gene

Vasoactive intestinal peptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for VIP Gene

GeneLoc Exon Structure for
VIP
ECgene alternative splicing isoforms for
VIP

Expression for VIP Gene

mRNA expression in normal human tissues for VIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VIP Gene

This gene is overexpressed in Colon - Sigmoid (x11.2) and Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for VIP Gene

This gene is overexpressed in Colon muscle (39.1) and Colon (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VIP Gene



SOURCE GeneReport for Unigene cluster for VIP Gene Hs.53973

genes like me logo Genes that share expression patterns with VIP: view

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for VIP Gene

Orthologs for VIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VIP 35
  • 87.06 (n)
  • 86.47 (a)
VIP 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VIP 35
  • 88.04 (n)
  • 86.47 (a)
VIP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vip 35
  • 80.59 (n)
  • 79.41 (a)
Vip 16
Vip 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VIP 35
  • 99.41 (n)
  • 100 (a)
VIP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vip 35
  • 82.75 (n)
  • 82.35 (a)
oppossum
(Monodelphis domestica)
Mammalia VIP 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VIP 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves VIP 35
  • 71.13 (n)
  • 64.57 (a)
VIP 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VIP 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vip 35
  • 70.87 (n)
  • 72.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia vip-A 35
zebrafish
(Danio rerio)
Actinopterygii vip 35
  • 66.67 (n)
  • 71.11 (a)
vip 36
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14201 35
Species with no ortholog for VIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIP Gene

ENSEMBL:
Gene Tree for VIP (if available)
TreeFam:
Gene Tree for VIP (if available)

Paralogs for VIP Gene

Paralogs for VIP Gene

(1) SIMAP similar genes for VIP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with VIP: view

Variants for VIP Gene

Sequence variations from dbSNP and Humsavar for VIP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1321967 -- 152,759,055(+) TGTGA(A/T)GTTTA utr-variant-3-prime
rs1321968 -- 152,759,102(+) TTTAA(A/C)TCATA utr-variant-3-prime
rs1407264 -- 152,757,815(+) TTTTT(C/T)TTTGT intron-variant
rs1407267 -- 152,749,316(+) CATTT(G/T)TCTGT upstream-variant-2KB, utr-variant-5-prime
rs11960995 -- 152,747,831(+) GAATC(C/T)GGGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VIP Gene

Variant ID Type Subtype PubMed ID
dgv2017e1 CNV Complex 17122850

Variation tolerance for VIP Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VIP Gene

Human Gene Mutation Database (HGMD)
VIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIP Gene

Disorders for VIP Gene

MalaCards: The human disease database

(48) MalaCards diseases for VIP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vipoma
  • malignant vasoactive intestinal peptide-secreting tumor
wdha syndrome
  • pancreatic cholera
vasomotor rhinitis
  • rhinitis vasomotor
ganglioneuroma
chemical colitis
- elite association - COSMIC cancer census association via MalaCards
Search VIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for VIP

Genetic Association Database (GAD)
VIP
Human Genome Epidemiology (HuGE) Navigator
VIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VIP
genes like me logo Genes that share disorders with VIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VIP Gene

Publications for VIP Gene

  1. Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (PMID: 1318039) Kitamura K. … Eto T. (Biochem. Biophys. Res. Commun. 1992) 3 4 67
  2. Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation. (PMID: 20007697) Tee A.E. … Liu T. (J. Biol. Chem. 2010) 3 23
  3. Signaling pathways in PACAP regulation of VIP gene expression in human neuroblastoma cells. (PMID: 19712974) Falktoft B. … Fahrenkrug J. (Neuropeptides 2009) 3 23
  4. Regulation of vasoactive intestinal peptide and substance P in the human pyloric sphincter. (PMID: 19950799) Tomita R. (Hepatogastroenterology 2009) 3 23
  5. Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse. (PMID: 18351280) Hong X. … Song Y. (Int Urogynecol J Pelvic Floor Dysfunct 2008) 3 23

Products for VIP Gene

Sources for VIP Gene

Content