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VIMP Gene

protein-coding   GIFtS: 49
GCID: GC15M101813

VCP-Interacting Membrane Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
VCP-Interacting Membrane Protein1 2 3     SEPS12 5
SELS2 3 5     SBBI82
Selenoprotein S1 2     SelS3
ADO152 5     

External Ids:    HGNC: 303961   Entrez Gene: 558292   Ensembl: ENSG000001318717   OMIM: 6079185   UniProtKB: Q9BQE43   

Export aliases for VIMP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VIMP Gene:
This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the
active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3'
UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is
necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this
protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Sep 2013)

GeneCards Summary for VIMP Gene:
VIMP (VCP-interacting membrane protein) is a protein-coding gene. Diseases associated with VIMP include alpha 1-antitrypsin deficiency, and cerebrovascular disease. GO annotations related to this gene include enzyme binding and antioxidant activity.

UniProtKB/Swiss-Prot: SELS_HUMAN, Q9BQE4
Function: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins.
Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the
proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates
the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the
translocation and ubiquitination

Gene Wiki entry for VIMP (SELS) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for VIMP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVIMP promoter sequence
   Search Chromatin IP Primers for VIMP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VIMP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

VIMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIMP gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M101813:  view genomic region     (about GC identifiers)

Start:
101,811,022 bp from pter      End:
101,817,705 bp from pter
Size:
6,684 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SELS_HUMAN, Q9BQE4 (See protein sequence)
Recommended Name: Selenoprotein S  
Size: 189 amino acids; 21163 Da
Subunit: Interacts with DERL1 and VCP, suggesting that it forms a membrane complex with DERL1 that serves as a
receptor for VCP. Also interacts with DERL2, DERL3 and SELK. The SELK-VIMP complex interacts with VCP. Part of a
complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP
Sequence caution: Sequence=AAF67483.1; Type=Frameshift; Positions=173; Sequence=AAK15708.1; Type=Erroneous
termination; Positions=188; Note=Translated as Sec;
1 PDB 3D structure from and Proteopedia for VIMP:
2Q2F (3D)    
Secondary accessions: Q3B771 Q9P0I6

Explore the universe of human proteins at neXtProt for VIMP: NX_Q9BQE4

Explore proteomics data for VIMP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77
  • Modification sites at PhosphoSitePlus

  • See VIMP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_060915.2  NP_982298.2  

    ENSEMBL proteins: 
     ENSP00000381282   ENSP00000433803   ENSP00000433541   ENSP00000434842   ENSP00000437381  

    VIMP Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009703 Selenoprotein_S

    Graphical View of Domain Structure for InterPro Entry Q9BQE4

    ProtoNet protein and cluster: Q9BQE4

    1 Blocks protein domain: IPB009703 Selenoprotein S

    UniProtKB/Swiss-Prot: SELS_HUMAN, Q9BQE4
    Similarity: Belongs to the selenoprotein S family


    VIMP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SELS_HUMAN, Q9BQE4
    Function: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins.
    Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the
    proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates
    the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the
    translocation and ubiquitination

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS15215856
    GO:0005515protein binding IPI15215856
    GO:0008430selenium binding IEA--
    GO:0016209antioxidant activity IDA15063746
    GO:0019899enzyme binding IPI15215856
         
    VIMP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VIMP:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Vimp (no phenotypes)

    VIMP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VIMP
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SELS_HUMAN, Q9BQE4: Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005881cytoplasmic microtubule IDA--
    GO:0005886plasma membrane TAS12663463
    GO:0030176integral component of endoplasmic reticulum membrane IDA15215856
    GO:0034361very-low-density lipoprotein particle IDA17374524

    VIMP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for VIMP About    
    See pathways by source

    SuperPathContained pathways About
    1Selenium Pathway
    Selenium Pathway
    2Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for VIMP
        Selenium Metabolism and Selenoproteins
    Selenium Pathway



    1 Kegg Pathway  (Kegg details for VIMP):
        Protein processing in endoplasmic reticulum


    VIMP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for VIMP
    Interactions:

        Search GeneGlobe Interaction Network for VIMP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for VIMP (Q9BQE41, 3 ENSP000003812824) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550723, ENSP000003517774I2D: score=3 STRING: ENSP00000351777
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    HERPUD1Q150113, ENSP000003003024I2D: score=1 STRING: ENSP00000300302
    KPNB1Q149743, ENSP000002901584I2D: score=1 STRING: ENSP00000290158
    SVIPQ8NHG73, ENSP000003461304I2D: score=1 STRING: ENSP00000346130
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002865negative regulation of acute inflammatory response to antigenic stimulus IMP18675776
    GO:0006111regulation of gluconeogenesis TAS12663463
    GO:0006886intracellular protein transport ----
    GO:0006983ER overload response IMP17210132
    GO:0009749response to glucose IEP12031974

    VIMP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VIMP (SELS)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for VIMP gene (2 alternative transcripts): 
    NM_018445.5  NM_203472.2  

    Unigene Cluster for VIMP:

    VCP-interacting membrane protein
    Hs.32148  [show with all ESTs]
    Unigene Representative Sequence: NM_203472
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398226 ENST00000531964 ENST00000526049 ENST00000526043(uc021sxv.1)
    ENST00000528346 ENST00000527833 ENST00000529968 ENST00000534014 ENST00000537379(uc021sxu.1)

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat VIMP
      QuantiFast Probe-based Assays in human, mouse, rat VIMP

    Additional mRNA sequence: 

    AF157317.1 AF328864.1 AK026455.1 AK225955.1 AK314723.1 AY324824.1 AY618665.1 BC005840.2 
    BC107774.1 

    13 DOTS entries:

    DT.446020  DT.99938478  DT.121031424  DT.309724  DT.100819802  DT.102826315  DT.95200111  DT.97844213 
    DT.100643238  DT.101971440  DT.92415887  DT.92428698  DT.95200114 

    Selected AceView cDNA sequences (see all 182):

    BE207946 AI000204 AV709860 AI936756 BI833610 BI769582 BM924684 AI936779 
    BU686166 AI349446 AI167172 AY618665 AA330253 CB216657 BU742679 NM_203472 
    AK097011 BC005840 CA489855 BM728761 BI917440 AA305753 AA356389 AA487772 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VIMP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
    SP1:        -                 -                 -                 -         
    SP2:        -                 -                 -                           
    SP3:                          -                 -                           
    SP4:        -                 -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for VIMP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VIMP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    VIMP Expression
    About this image


    VIMP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    VIMP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VIMP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32148
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for VIMP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vimp1 , 5 histocompatibility 475
    VCP-interacting membrane protein1
    84.85(n)1
    83.96(a)1
      7 (35.49 cM)5
    1098151  NM_024439.31  NP_077759.31 
     660796495 
    chicken
    (Gallus gallus)
    Aves VIMP1 VCP-interacting membrane protein 69.44(n)
    67.22(a)
      415522  NM_001024734.2  NP_001019905.1 
    lizard
    (Anolis carolinensis)
    Reptilia VIMP6
    VCP-interacting membrane protein
    63(a)
    1 ↔ 1
    GL343941.1(32844-35257)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142572 Xenopus laevis transcribed sequence with weak similarity more 72.14(n)    BJ059650.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vimp1 VCP-interacting membrane protein 56.32(n)
    52.3(a)
      735249  NM_001045334.2  NP_001038799.2 


    ENSEMBL Gene Tree for VIMP (if available)
    TreeFam Gene Tree for VIMP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VIMP gene
    1 SIMAP similar gene for VIMP using alignment to 3 protein entries:     SELS_HUMAN (see all proteins):
    SELS

    VIMP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VIMP (see all 246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113271261,2
    C,F--77940337(+) CTTTC-/TTTTTT 2 -- us2k1 trp34Minor allele frequency- T:0.38NA CSA 8
    rs563447051,2
    C,F--81534932(+) CATATC/TAGTCA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1120974581,2
    C,F--81534953(+) GAACTC/TCTGAC 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1166596671,2
    C,F--81534999(+) CAGGCG/ATGAGC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1402045491,2
    C--81535039(+) TAGCTA/GCAAGA 1 -- ds50010--------
    rs1422665271,2
    --81535097(+) AAGGAA/TGAAGT 1 -- ds50010--------
    rs1512566241,2
    --81535149(+) TCTAAC/GCTTCA 1 -- ds50010--------
    rs608029921,2
    C--81535186(+) TACCCG/ATTTCA 1 -- ds50018Minor allele frequency- A:0.40WA NA CSA EA 366
    rs1404858391,2
    --81535308(+) TTCTCC/TCTGAC 1 -- ds50010--------
    rs740419501,2
    C,F--81535326(+) TTCCAC/TCCCTA 1 -- ds50011Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for VIMP (101811022 - 101817705 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VIMP: --
    Human Gene Mutation Database (HGMD): VIMP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VIMP
    DNA2.0 Custom Variant and Variant Library Synthesis for VIMP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607918    OMIM disorders: --

    13 diseases for VIMP:    
    About MalaCards
    alpha 1-antitrypsin deficiency    cerebrovascular disease    coronary heart disease    brain injury
    tonsillitis    inflammatory bowel disease    ischemia    diabetes mellitus
    atherosclerosis    colorectal cancer    rheumatoid arthritis    arthritis
    prostatitis


    VIMP for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for VIMP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 35.9 9 16227999 (2), 18007060 (2), 17641917 (1), 17661913 (1)


    Export disorders for VIMP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VIMP gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with VIMP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. (PubMed id 16186510)1, 2, 3 Ye Y....Rapoport T.A. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. Genetic variation in selenoprotein S influences inflammatory response. (PubMed id 16227999)1, 3, 9 Curran J.E....Blangero J. (Nat. Genet. 2005)
    3. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. (PubMed id 16186509)1, 2 Lilley B.N. and Ploegh H.L. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    4. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. (PubMed id 15215856)1, 2 Ye Y.... Rapoport T.A. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (Science 2003)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. The role of the selenoprotein S (SELS) gene -105G&gt;A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation. (PubMed id 17661913)1, 9 Seiderer J....Brand S. (Tissue Antigens 2007)
    9. Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. (PubMed id 16574427)1, 9 Gao Y....Collier G.R. (Cytokine 2006)
    10. Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus. (PubMed id 18710632)1, 9 Du J.L....Song G.R. (Chin. Med. J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55829 HGNC: 30396 AceView: SELS Ensembl:ENSG00000131871 euGenes: HUgn55829
    ECgene: VIMP Kegg: 55829 H-InvDB: VIMP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VIMP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VIMP gene:
    Search GeneIP for patents involving VIMP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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