Aliases for VIMP Gene
External Ids for VIMP Gene
Previous GeneCards Identifiers for VIMP Gene
This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
GeneCards Summary for VIMP Gene
VIMP (VCP Interacting Membrane Selenoprotein) is a Protein Coding gene. Diseases associated with VIMP include Pontocerebellar Hypoplasia Type 2D. Among its related pathways are Selenium Metabolism and Selenoproteins and Protein processing in endoplasmic reticulum. GO annotations related to this gene include enzyme binding and antioxidant activity.
UniProtKB/Swiss-Prot for VIMP Gene
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.