Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VIMP Gene

protein-coding   GIFtS: 48
GCID: GC15M101813

VCP-Interacting Membrane Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
VCP-Interacting Membrane Protein1 2 3     SEPS12 5
SELS2 3 5     SBBI82
Selenoprotein S1 2     SelS3
ADO152 5     

External Ids:    HGNC: 303961   Entrez Gene: 558292   Ensembl: ENSG000001318717   OMIM: 6079185   UniProtKB: Q9BQE43   

Export aliases for VIMP gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VIMP Gene:
This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the
active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3'
UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is
necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this
protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Sep 2013)

GeneCards Summary for VIMP Gene: 
VIMP (VCP-interacting membrane protein) is a protein-coding gene. Diseases associated with VIMP include alpha 1-antitrypsin deficiency, and cerebrovascular disease. GO annotations related to this gene include enzyme binding and antioxidant activity.

UniProtKB/Swiss-Prot: SELS_HUMAN, Q9BQE4
Function: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins.
Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the
proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates
the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the
translocation and ubiquitination

Gene Wiki entry for VIMP (SELS) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010274.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for VIMP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVIMP promoter sequence
   Search SABiosciences Chromatin IP Primers for VIMP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VIMP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

VIMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIMP gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M101813:  view genomic region     (about GC identifiers)

Start:
101,811,022 bp from pter      End:
101,817,705 bp from pter
Size:
6,684 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SELS_HUMAN, Q9BQE4 (See protein sequence)
Recommended Name: Selenoprotein S  
Size: 189 amino acids; 21163 Da
Subunit: Interacts with DERL1 and VCP, suggesting that it forms a membrane complex with DERL1 that serves as a
receptor for VCP
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm (By similarity)
Sequence caution: Sequence=AAF67483.1; Type=Frameshift; Positions=173; Sequence=AAK15708.1; Type=Erroneous
termination; Positions=188; Note=Translated as Sec;
1 PDB 3D structure from and Proteopedia for VIMP:
2Q2F (3D)    
Secondary accessions: Q3B771 Q9P0I6

Explore the universe of human proteins at neXtProt for VIMP: NX_Q9BQE4

Explore proteomics data for VIMP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BQE4

  • VIMP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VIMP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_060915.2  NP_982298.2  

    ENSEMBL proteins: 
     ENSP00000381282   ENSP00000433803   ENSP00000433541   ENSP00000434842   ENSP00000437381  

    Human Recombinant Protein Products for VIMP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for VIMP
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for VIMP
    GenScript Custom Purified and Recombinant Proteins Services for VIMP
    Novus Biologicals VIMP Protein
    Novus Biologicals VIMP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005881cytoplasmic microtubule IDA--
    GO:0005886plasma membrane TAS12663463
    GO:0030176integral to endoplasmic reticulum membrane IDA15215856
    GO:0034361very-low-density lipoprotein particle IDA17374524

    VIMP for ontologies           About GeneDecksing



    VIMP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for VIMP
    GenScript Custom Superior Antibodies Services for VIMP
    Novus Biologicals VIMP Antibodies
    Abcam antibodies for VIMP
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for VIMP
    LSBio Antibodies in human, mouse, rat for VIMP 

    Assay Products for VIMP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for VIMP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VIMP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009703 Selenoprotein_S

    Graphical View of Domain Structure for InterPro Entry Q9BQE4

    ProtoNet protein and cluster: Q9BQE4

    1 Blocks protein domain: IPB009703 Selenoprotein S

    UniProtKB/Swiss-Prot: SELS_HUMAN, Q9BQE4
    Similarity: Belongs to the selenoprotein S family


    VIMP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SELS_HUMAN, Q9BQE4
    Function: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins.
    Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the
    proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates
    the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the
    translocation and ubiquitination

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS15215856
    GO:0005515protein binding IPI15215856
    GO:0008430selenium binding IEA--
    GO:0016209antioxidant activity IDA15063746
    GO:0019899enzyme binding IPI15215856
         
    VIMP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VIMP:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Vimp (no phenotypes)

    VIMP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for VIMP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VIMP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VIMP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VIMP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIMP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate VIMP
    SwitchGear 3'UTR luciferase reporter plasmidVIMP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VIMP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIMP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for VIMP
    Sirion Biotech Customized adenovirus for overexpression of VIMP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for VIMP (see all 12)
    OriGene ORF clones in mouse, rat for VIMP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for VIMP
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIMP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIMP
    Sirion Biotech Customized lentivirus for stable overexpression of VIMP 
                         Customized lentivirus expression plasmids for stable overexpression of VIMP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for VIMP
    Search LifeMap BioReagents cell lines for VIMP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIMP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for VIMP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    3Selenium Pathway
    Selenium Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for VIMP
        Selenium Metabolism and Selenoproteins
    Selenium Pathway


    1         Kegg Pathway  (Kegg details for VIMP):
        Protein processing in endoplasmic reticulum


    VIMP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VIMP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/22 Interacting proteins for VIMP (Q9BQE41, 3 ENSP000003812824) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550723, ENSP000003517774I2D: score=3 STRING: ENSP00000351777
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    HERPUD1Q150113, ENSP000003003024I2D: score=1 STRING: ENSP00000300302
    KPNB1Q149743, ENSP000002901584I2D: score=1 STRING: ENSP00000290158
    SVIPQ8NHG73, ENSP000003461304I2D: score=1 STRING: ENSP00000346130
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002865negative regulation of acute inflammatory response to antigenic stimulus IMP18675776
    GO:0006111regulation of gluconeogenesis TAS12663463
    GO:0006886intracellular protein transport ----
    GO:0006983ER overload response IMP17210132
    GO:0009749response to glucose stimulus IEP12031974

    VIMP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VIMP (SELS)

    Search CenterWatch for drugs/clinical trials and news about VIMP / SELS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VIMP gene (2 alternative transcripts): 
    NM_018445.5  NM_203472.2  

    Unigene Cluster for VIMP:

    VCP-interacting membrane protein
    Hs.32148  [show with all ESTs]
    Unigene Representative Sequence: NM_203472
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398226 ENST00000531964 ENST00000526049 ENST00000526043(uc021sxv.1)
    ENST00000528346 ENST00000527833 ENST00000529968 ENST00000534014 ENST00000537379(uc021sxu.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VIMP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate VIMP
    SwitchGear 3'UTR luciferase reporter plasmidVIMP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VIMP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIMP
    Clone
    Products:
         
    OriGene clones in human, mouse for VIMP (see all 12)
    OriGene ORF clones in mouse, rat for VIMP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for VIMP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VIMP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIMP
    Sirion Biotech Customized lentivirus for stable overexpression of VIMP 
                         Customized lentivirus expression plasmids for stable overexpression of VIMP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VIMP
    OriGene qSTAR qPCR primer pairs in human, mouse for VIMP
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat VIMP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIMP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIMP

    Additional mRNA sequence: 

    AF157317.1 AF328864.1 AK026455.1 AK225955.1 AK314723.1 AY324824.1 AY618665.1 BC005840.2 
    BC107774.1 

    13 DOTS entries:

    DT.446020  DT.99938478  DT.121031424  DT.309724  DT.100819802  DT.102826315  DT.95200111  DT.97844213 
    DT.100643238  DT.101971440  DT.92415887  DT.92428698  DT.95200114 

    24/182 AceView cDNA sequences (see all 182):

    AU279601 AI160638 AA877181 BE207946 BI769582 AA330253 AA305753 AI880695 
    BC005840 NM_018445 BM728761 CB216657 AA487772 AL697898 CD672211 AI936756 
    AI936779 BI833610 AI655441 NM_203472 BE019242 AI000204 BU617011 AI554904 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for VIMP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
    SP1:        -                 -                 -                 -         
    SP2:        -                 -                 -                           
    SP3:                          -                 -                           
    SP4:        -                 -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for VIMP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VIMP expression in normal human tissues (normalized intensities)      VIMP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    VIMP Expression
    About this image


    VIMP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See VIMP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VIMP

    SOURCE GeneReport for Unigene cluster: Hs.32148
        SABiosciences Custom PCR Arrays for VIMP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VIMP
    OriGene qSTAR qPCR primer pairs in human, mouse for VIMP
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat VIMP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIMP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIMP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIMP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for VIMP gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vimp1 , 5 histocompatibility 475
    VCP-interacting membrane protein1
    84.85(n)1
    83.96(a)1
      7 (35.49 cM)5
    1098151  NM_024439.31  NP_077759.31 
     660796495 
    chicken
    (Gallus gallus)
    Aves VIMP1 VCP-interacting membrane protein 69.46(n)
    67.6(a)
      415522  NM_001024734.2  NP_001019905.1 
    lizard
    (Anolis carolinensis)
    Reptilia VIMP6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343941.1(32844-35257)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142572 Xenopus laevis transcribed sequence with weak similarity more 72.14(n)    BJ059650.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vimp1 VCP-interacting membrane protein 56.32(n)
    52.3(a)
      735249  NM_001045334.2  NP_001038799.2 


    ENSEMBL Gene Tree for VIMP (if available)
    TreeFam Gene Tree for VIMP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VIMP gene
    1 SIMAP similar gene for VIMP using alignment to 4 protein entries:     SELS_HUMAN (see all proteins):
    SELS

    VIMP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/246 SNPs in VIMP are shown (see all 246)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113271261,2
    C,F--77940337(+) CTTTC-/TTTTTT 2 -- us2k1 trp34Minor allele frequency- T:0.38NA CSA 8
    rs563447051,2
    C,F--81534932(+) CATATC/TAGTCA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1120974581,2
    C,F--81534953(+) GAACTC/TCTGAC 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1166596671,2
    C,F--81534999(+) CAGGCG/ATGAGC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1402045491,2
    C--81535039(+) TAGCTA/GCAAGA 1 -- ds50010--------
    rs1422665271,2
    --81535097(+) AAGGAA/TGAAGT 1 -- ds50010--------
    rs1512566241,2
    --81535149(+) TCTAAC/GCTTCA 1 -- ds50010--------
    rs608029921,2
    C--81535186(+) TACCCG/ATTTCA 1 -- ds50018Minor allele frequency- A:0.40WA NA CSA EA 366
    rs1404858391,2
    --81535308(+) TTCTCC/TCTGAC 1 -- ds50010--------
    rs740419501,2
    C,F--81535326(+) TTCCAC/TCCCTA 1 -- ds50011Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for VIMP (101811022 - 101817705 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for VIMP: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VIMP
    DNA2.0 Custom Variant and Variant Library Synthesis for VIMP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607918    OMIM disorders: --

    10 diseases for VIMP:    About MalaCards
    alpha 1-antitrypsin deficiency    cerebrovascular disease    coronary heart disease    brain injury
    inflammatory bowel disease    diabetes mellitus    atherosclerosis    ischemia
    gastric cancer    colorectal cancer


    VIMP for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for VIMP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 35.9 9 16227999 (2), 18007060 (2), 17641917 (1), 17661913 (1)


    Export disorders for VIMP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VIMP gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with VIMP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. (PubMed id 16186510)1, 2, 3 Ye Y....Rapoport T.A. (2005)
    2. Genetic variation in selenoprotein S influences inflammatory response. (PubMed id 16227999)1, 3, 9 Curran J.E....Blangero J. (2005)
    3. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. (PubMed id 16186509)1, 2 Lilley B.N. and Ploegh H.L. (2005)
    4. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. (PubMed id 15215856)1, 2 Ye Y.... Rapoport T.A. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of mammalian selenoproteomes. (PubMed id 12775843)1, 2 Kryukov G.V.... Gladyshev V.N. (2003)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation. (PubMed id 17661913)1, 9 Seiderer J....Brand S. (2007)
    9. Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. (PubMed id 16574427)1, 9 Gao Y....Collier G.R. (2006)
    10. Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus. (PubMed id 18710632)1, 9 Du J.L....Song G.R. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55829 HGNC: 30396 AceView: SELS Ensembl:ENSG00000131871 euGenes: HUgn55829
    ECgene: VIMP Kegg: 55829 H-InvDB: VIMP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VIMP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VIMP gene:
    Search GeneIP for patents involving VIMP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for VIMP  
     OriGene qPCR primer pairs and template standards for VIMP   OriGene Protein Over-expression Lysate for VIMP  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for VIMP  
     OriGene qSTAR qPCR primer pairs in human, mouse for VIMP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for VIMP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for VIMP   OriGene Custom Protein Services for VIMP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VIMP
     QIAGEN SeqTarget long-range PCR primers for resequencing VIMP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VIMP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VIMP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VIMP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VIMP
     GenScript Custom Purified and Recombinant Proteins Services for VIMP GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for VIMP
     GenScript Custom Assay Services for VIMP GenScript Custom Superior Antibodies Services for VIMP
     GenScript Custom overexpressing Cell Line Services for VIMP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for VIMP
     Search Chromatin IP Primers for VIMP
     Search RT2 qPCR Primer Assays in human, mouse, rat VIMP
     Search GNC Networks for VIMP
     SABiosciences Custom PCR Arrays for VIMP
     Search Tocris compounds for VIMP (SELS)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     VIMP antibodies
     VIMP proteins
     VIMP lysates
     Antibodies for VIMP
     See all of Abcam's Antibodies, Kits and Proteins for VIMP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for VIMP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIMP
     SwitchGear 3'UTR luciferase reporter plasmids for VIMP
     SwitchGear Promoter luciferase reporter plasmids for VIMP
     ThermoFisher Antibodies for VIMP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VIMP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for VIMP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VIMP
    Customized:
     lentivirus for stable overexpression of VIMP
     lentivirus expression plasmids for stable overexpression of VIMP
     adenovirus for overexpression of VIMP
     LSBio Antibodies in human, mouse, rat for VIMP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      VIMP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4