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Aliases for VIMP Gene

Aliases for VIMP Gene

  • VCP-Interacting Membrane Protein 2 3 4
  • SELS 3 4 6
  • Selenoprotein S 2 3
  • ADO15 3 6
  • SEPS1 3 6
  • AD-015 3
  • SBBI8 3

External Ids for VIMP Gene

Previous GeneCards Identifiers for VIMP Gene

  • GC15M101813

Summaries for VIMP Gene

Entrez Gene Summary for VIMP Gene

  • This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

GeneCards Summary for VIMP Gene

VIMP (VCP-Interacting Membrane Protein) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins and Protein processing in endoplasmic reticulum. GO annotations related to this gene include enzyme binding and antioxidant activity.

UniProtKB/Swiss-Prot for VIMP Gene

  • Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

Gene Wiki entry for VIMP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIMP Gene

Genomics for VIMP Gene

Genomic Location for VIMP Gene

Start:
101,270,817 bp from pter
End:
101,277,520 bp from pter
Size:
6,704 bases
Orientation:
Minus strand

Genomic View for VIMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VIMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIMP Gene

No data available for Regulatory Elements for VIMP Gene

Proteins for VIMP Gene

  • Protein details for VIMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQE4-SELS_HUMAN
    Recommended name:
    Selenoprotein S
    Protein Accession:
    Q9BQE4
    Secondary Accessions:
    • Q3B771
    • Q9P0I6

    Protein attributes for VIMP Gene

    Size:
    189 amino acids
    Molecular mass:
    21163 Da
    Quaternary structure:
    • Interacts with DERL1 and (via VIM motif) with VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Also interacts with DERL2, DERL3 and SELK. The SELK-VIMP complex interacts with VCP. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP.
    SequenceCaution:
    • Sequence=AAF67483.1; Type=Frameshift; Positions=173; Evidence={ECO:0000305}; Sequence=AAK15708.1; Type=Erroneous termination; Positions=188; Note=Translated as Sec.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VIMP Gene

neXtProt entry for VIMP Gene

Proteomics data for VIMP Gene at MOPED

Post-translational modifications for VIMP Gene

  • Ubiquitination at Lys77
  • Modification sites at PhosphoSitePlus

Other Protein References for VIMP Gene

No data available for DME Specific Peptides for VIMP Gene

Domains for VIMP Gene

Protein Domains for VIMP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BQE4

UniProtKB/Swiss-Prot:

SELS_HUMAN :
  • Q9BQE4
Family:
  • Belongs to the selenoprotein S family.
genes like me logo Genes that share domains with VIMP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for VIMP Gene

Function for VIMP Gene

Molecular function for VIMP Gene

UniProtKB/Swiss-Prot Function: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

Gene Ontology (GO) - Molecular Function for VIMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 15215856
GO:0005515 protein binding IPI 15215856
GO:0008430 selenium binding IEA --
GO:0016209 antioxidant activity IDA 15063746
GO:0019899 enzyme binding IPI 15215856
genes like me logo Genes that share ontologies with VIMP: view

Phenotypes for VIMP Gene

GenomeRNAi human phenotypes for VIMP:
genes like me logo Genes that share phenotypes with VIMP: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VIMP Gene

Localization for VIMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIMP Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm.

Gene Ontology (GO) - Cellular Components for VIMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005881 cytoplasmic microtubule IDA 23264731
GO:0005886 plasma membrane TAS 12663463
GO:0030176 integral component of endoplasmic reticulum membrane IDA 15215856
GO:0034361 very-low-density lipoprotein particle IDA 17374524
genes like me logo Genes that share ontologies with VIMP: view

No data available for Subcellular locations from COMPARTMENTS for VIMP Gene

Pathways for VIMP Gene

genes like me logo Genes that share pathways with VIMP: view

Pathways by source for VIMP Gene

2 BioSystems pathways for VIMP Gene
1 KEGG pathway for VIMP Gene

Gene Ontology (GO) - Biological Process for VIMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus IMP 18675776
GO:0006111 regulation of gluconeogenesis TAS 12663463
GO:0006886 intracellular protein transport --
GO:0006983 ER overload response IMP 17210132
GO:0009749 response to glucose IEP 12031974
genes like me logo Genes that share ontologies with VIMP: view

Transcripts for VIMP Gene

Unigene Clusters for VIMP Gene

VCP-interacting membrane protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VIMP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for VIMP Gene

GeneLoc Exon Structure for
VIMP
ECgene alternative splicing isoforms for
VIMP

Expression for VIMP Gene

mRNA expression in normal human tissues for VIMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VIMP Gene

SOURCE GeneReport for Unigene cluster for VIMP Gene Hs.32148

genes like me logo Genes that share expressions with VIMP: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VIMP Gene

Orthologs for VIMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELS 36
  • 98 (a)
OneToOne
VIMP 35
  • 98.94 (n)
  • 98.94 (a)
cow
(Bos Taurus)
Mammalia VIMP 35
  • 87.83 (n)
  • 91.53 (a)
VIMP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VIMP 35
  • 89.42 (n)
  • 92.55 (a)
VIMP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vimp 35
  • 84.85 (n)
  • 83.96 (a)
Vimp 16
Vimp 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VIMP 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VIMP 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vimp 35
  • 85.03 (n)
  • 84.49 (a)
chicken
(Gallus gallus)
Aves VIMP 35
  • 69.44 (n)
  • 67.22 (a)
VIMP 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VIMP 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14257 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11154 35
vimp 35
  • 57.52 (n)
  • 55.43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7106 35
zebrafish
(Danio rerio)
Actinopterygii vimp 35
  • 56.32 (n)
  • 52.3 (a)
vimp 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for VIMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIMP Gene

ENSEMBL:
Gene Tree for VIMP (if available)
TreeFam:
Gene Tree for VIMP (if available)

Paralogs for VIMP Gene

Selected SIMAP similar genes for VIMP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VIMP: view

No data available for Paralogs for VIMP Gene

Variants for VIMP Gene

Sequence variations from dbSNP and Humsavar for VIMP Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs9874 -- 101,271,199(-) TGAAT(A/G)TATTT utr-variant-3-prime
rs2009892 -- 101,275,957(-) gcaac(A/G)gagtg intron-variant
rs2009895 -- 101,276,024(-) AAATC(A/G)CTTGA intron-variant
rs2291250 -- 101,274,576(+) CCGGC(C/T)GAGGT intron-variant
rs2306534 -- 101,275,488(+) TTTAC(A/G)TAAGT intron-variant

Relevant External Links for VIMP Gene

HapMap Linkage Disequilibrium report
VIMP
Human Gene Mutation Database (HGMD)
VIMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VIMP Gene

Disorders for VIMP Gene

(1) Novoseek inferred disease relationships for VIMP Gene

Disease -log(P) Hits PubMed IDs
inflammation 35.9 6
genes like me logo Genes that share disorders with VIMP: view

No data available for UniProtKB/Swiss-Prot for VIMP Gene

Publications for VIMP Gene

  1. Genetic variation in selenoprotein S influences inflammatory response. (PMID: 16227999) Curran J.E. … Blangero J. (Nat. Genet. 2005) 2 3 23
  2. Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. (PMID: 16186510) Ye Y. … Rapoport T.A. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4
  3. The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. (PMID: 16289116) Schulze A. … Seeger M. (J. Mol. Biol. 2005) 3 23
  4. Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells. (PMID: 16574427) Gao Y. … Collier G.R. (Cytokine 2006) 3 23
  5. SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis. (PMID: 17210132) Kim K.H. … Kissebah A.H. (Biochem. Biophys. Res. Commun. 2007) 3 23

Products for VIMP Gene

Sources for VIMP Gene

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