External Ids for VIM Gene
Previous GeneCards Identifiers for VIM Gene
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
GeneCards Summary for VIM Gene
VIM (Vimentin) is a Protein Coding gene. Diseases associated with VIM include Cataract 30, Pulverulent and Malignant Mixed Mullerian Tumor. Among its related pathways are Immune System and Primary Focal Segmental Glomerulosclerosis FSGS. GO annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is DES.
UniProtKB/Swiss-Prot for VIM Gene
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.