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Aliases for VIM Gene

Aliases for VIM Gene

  • Vimentin 2 3 5
  • Epididymis Luminal Protein 113 3
  • CTRCT30 3
  • HEL113 3

External Ids for VIM Gene

Previous GeneCards Identifiers for VIM Gene

  • GC10P017253
  • GC10P017421
  • GC10P017275
  • GC10P017310
  • GC10P017270

Summaries for VIM Gene

Entrez Gene Summary for VIM Gene

  • This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

GeneCards Summary for VIM Gene

VIM (Vimentin) is a Protein Coding gene. Diseases associated with VIM include cataract 30, pulverulent and pulverulent cataract. Among its related pathways are MicroRNAs in cancer and Cardiac conduction. GO annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is KRT82.

UniProtKB/Swiss-Prot for VIM Gene

  • Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

  • Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.

Gene Wiki entry for VIM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VIM Gene

Genomics for VIM Gene

Regulatory Elements for VIM Gene

Genomic Location for VIM Gene

Chromosome:
10
Start:
17,227,935 bp from pter
End:
17,237,593 bp from pter
Size:
9,659 bases
Orientation:
Plus strand

Genomic View for VIM Gene

Genes around VIM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VIM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VIM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VIM Gene

Proteins for VIM Gene

  • Protein details for VIM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08670-VIME_HUMAN
    Recommended name:
    Vimentin
    Protein Accession:
    P08670
    Secondary Accessions:
    • B0YJC2
    • D3DRU4
    • Q15867
    • Q15868
    • Q15869
    • Q548L2
    • Q6LER9
    • Q8N850
    • Q96ML2
    • Q9NTM3

    Protein attributes for VIM Gene

    Size:
    466 amino acids
    Molecular mass:
    53652 Da
    Quaternary structure:
    • Homopolymer assembled from elementary dimers. Interacts with HCV core protein (PubMed:15846844). Interacts with LGSN and SYNM. Interacts (via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with SLC6A4 (PubMed:19270731). Interacts with STK33 (PubMed:18811945). Interacts with LARP6 (PubMed:21746880). Interacts with RAB8B (By similarity). Interacts with TOR1A; the interaction associates TOR1A with the cytoskeleton (PubMed:16361107, PubMed:18827015). Interacts with TOR1AIP1 (PubMed:16361107). Interacts with BCAS3 (PubMed:17505058). Interacts with DIAPH1 (PubMed:23325789). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity).
    SequenceCaution:
    • Sequence=BAB71275.1; Type=Miscellaneous discrepancy; Note=Product of a cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for VIM Gene

neXtProt entry for VIM Gene

Proteomics data for VIM Gene at MOPED

Post-translational modifications for VIM Gene

  • Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
  • O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status.
  • S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Ubiquitination at Lys 97, Lys 120, Lys 129, Lys 139, Lys 168, Lys 188, Lys 236, Lys 282, Lys 294, Lys 313, Lys 373, and Lys 445
  • Glycosylation at Ser 7, Thr 33, and Ser 34
  • Modification sites at PhosphoSitePlus

Other Protein References for VIM Gene

Protein Products

No data available for DME Specific Peptides for VIM Gene

Domains & Families for VIM Gene

Gene Families for VIM Gene

Protein Domains for VIM Gene

Suggested Antigen Peptide Sequences for VIM Gene

Graphical View of Domain Structure for InterPro Entry

P08670

UniProtKB/Swiss-Prot:

VIME_HUMAN :
  • The central alpha-helical coiled-coil rod region mediates elementary homodimerization.
  • Belongs to the intermediate filament family.
Domain:
  • The central alpha-helical coiled-coil rod region mediates elementary homodimerization.
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with VIM: view

Function for VIM Gene

Molecular function for VIM Gene

GENATLAS Biochemistry:
vimentin,intermediate filament protein,expressed in cells of mesenchymal origin,regulated by an antisilencer element
UniProtKB/Swiss-Prot Function:
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
UniProtKB/Swiss-Prot Function:
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.

Gene Ontology (GO) - Molecular Function for VIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005200 structural constituent of cytoskeleton IDA 11889032
genes like me logo Genes that share ontologies with VIM: view
genes like me logo Genes that share phenotypes with VIM: view

Human Phenotype Ontology for VIM Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for VIM Gene

MGI Knock Outs for VIM:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for VIM Gene

Localization for VIM Gene

Subcellular locations from UniProtKB/Swiss-Prot for VIM Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VIM Gene COMPARTMENTS Subcellular localization image for VIM gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
peroxisome 5
mitochondrion 3
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for VIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031252 cell leading edge IEA --
GO:0043005 neuron projection IEA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with VIM: view

Pathways & Interactions for VIM Gene

genes like me logo Genes that share pathways with VIM: view

SIGNOR curated interactions for VIM Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for VIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0012501 programmed cell death TAS --
GO:0030049 muscle filament sliding TAS --
GO:0045103 intermediate filament-based process IEA --
genes like me logo Genes that share ontologies with VIM: view

Drugs & Compounds for VIM Gene

(81) Drugs for VIM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(75) Additional Compounds for VIM Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carnosine
  • b-Alanyl-L-histidine
  • b-Alanylhistidine
  • beta-Alanyl-L-histidine
  • beta-Alanylhistidine
  • Carnosine
305-84-0
genes like me logo Genes that share compounds with VIM: view

Transcripts for VIM Gene

Unigene Clusters for VIM Gene

Vimentin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VIM Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:

Relevant External Links for VIM Gene

GeneLoc Exon Structure for
VIM
ECgene alternative splicing isoforms for
VIM

Expression for VIM Gene

mRNA expression in normal human tissues for VIM Gene

mRNA differential expression in normal tissues according to GTEx for VIM Gene

This gene is overexpressed in Artery - Aorta (x4.3) and Artery - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for VIM Gene

This gene is overexpressed in Bone marrow stromal cell (17.5) and Adipocyte (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VIM Gene



SOURCE GeneReport for Unigene cluster for VIM Gene Hs.455493

mRNA Expression by UniProt/SwissProt for VIM Gene

P08670-VIME_HUMAN
Tissue specificity: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitts lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
genes like me logo Genes that share expression patterns with VIM: view

Protein tissue co-expression partners for VIM Gene

Primer Products

In Situ Assay Products

Orthologs for VIM Gene

This gene was present in the common ancestor of chordates.

Orthologs for VIM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VIM 35
  • 92.64 (n)
  • 97.57 (a)
VIM 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VIM 35
  • 94.49 (n)
  • 98.07 (a)
VIM 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vim 35
  • 91.61 (n)
  • 97.35 (a)
Vim 16
Vim 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VIM 35
  • 99.43 (n)
  • 99.57 (a)
VIM 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vim 35
  • 91.61 (n)
  • 97.35 (a)
oppossum
(Monodelphis domestica)
Mammalia VIM 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VIM 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves VIM 35
  • 83.59 (n)
  • 88.37 (a)
VIMENTIN 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VIM 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11198 35
vim 35
  • 73.45 (n)
  • 79.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia vim1 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
vim 35
  • 71.83 (n)
  • 73.12 (a)
vim 36
  • 71 (a)
OneToMany
viml 36
  • 68 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11950 35
Species with no ortholog for VIM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VIM Gene

ENSEMBL:
Gene Tree for VIM (if available)
TreeFam:
Gene Tree for VIM (if available)

Paralogs for VIM Gene

Paralogs for VIM Gene

Pseudogenes.org Pseudogenes for VIM Gene

genes like me logo Genes that share paralogs with VIM: view

Variants for VIM Gene

Sequence variations from dbSNP and Humsavar for VIM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_070100 -
rs3249 -- 17,237,518(-) TTAAT(A/G)GTATT utr-variant-3-prime
rs4903 -- 17,233,862(+) CGTGA(C/T)GTACG reference, synonymous-codon
rs9059 -- 17,237,413(+) TAGTT(C/G/T)TTAAC utr-variant-3-prime
rs9235 -- 17,237,400(+) TAGGA(A/G)TAAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VIM Gene

Variant ID Type Subtype PubMed ID
nsv894908 CNV Gain 21882294
nsv831801 CNV Gain 17160897
nsv508571 CNV Loss 20534489
esv2659900 CNV Deletion 23128226

Variation tolerance for VIM Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VIM Gene

HapMap Linkage Disequilibrium report
VIM
Human Gene Mutation Database (HGMD)
VIM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VIM Gene

Disorders for VIM Gene

MalaCards: The human disease database

(94) MalaCards diseases for VIM Gene - From: OMIM, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cataract 30, pulverulent
  • cataract 30
pulverulent cataract
  • cataract, coppock-like
malignant mixed mullerian tumor
  • carcinosarcoma
spindle cell carcinoma
  • sarcomatoid carcinoma
glomus tumor
  • glomus neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search VIM in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VIME_HUMAN
  • Cataract 30 (CTRCT30) [MIM:116300]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for VIM

Genetic Association Database (GAD)
VIM
Human Genome Epidemiology (HuGE) Navigator
VIM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VIM
genes like me logo Genes that share disorders with VIM: view

No data available for Genatlas for VIM Gene

Publications for VIM Gene

  1. The serine/threonine kinase Stk33 exhibits autophosphorylation and phosphorylates the intermediate filament protein Vimentin. (PMID: 18811945) Brauksiepe B. … Schmidt E.R. (BMC Biochem. 2008) 3 4 23 67
  2. Regulation of cell adhesion to collagen via beta1 integrins is dependent on interactions of filamin A with vimentin and protein kinase C epsilon. (PMID: 20171211) Kim H. … McCulloch C.A. (Exp. Cell Res. 2010) 3 23
  3. Diagnostic value and implications of vimentin expression in normal, reactive and neoplastic endocervical epithelium. (PMID: 20350213) Stewart C.J. … Little L. (Pathology 2010) 3 23
  4. Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment. (PMID: 18681838) Walter M. … Ioannou Y.A. (Biol. Cell 2009) 3 23
  5. The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. (PMID: 19270731) Ahmed B.A. … Kilic F. (PLoS ONE 2009) 3 23

Products for VIM Gene

Sources for VIM Gene

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