VIM Gene
protein-coding GIFtS : 71
GCID: GC10 P017270
vimentin
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Aliasesfor VIM gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Export aliases for VIM gene to outside databases Previous GC identifers: GC10P017253 GC10P017421 GC10P017275 GC10P017310
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Summariesfor VIM gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for VIM : This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.(provided by RefSeq, Jun 2009) UniProtKB/Swiss-Prot: VIME_HUMAN, P08670 Function : Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymalcells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally Function : Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2Gene Wiki entry for VIM (Vimentin)
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Genomic Viewsfor VIM gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_008705.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the VIM gene promoter: AREB6 Spz1 p53 MyoD Other transcription factors Search SABiosciences Chromatin IP Primers for VIM Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VIM
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13 VIM Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P017270: view genomic region
(about GC identifiers )
Start:
17,270,258 bp from pter
End:
17,279,592 bp from pter
Size:
9,335 bases
Orientation:
plus strand
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Proteinsfor VIM gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: VIME_HUMAN, P08670 (See
protein sequence )Recommended Name: Vimentin Size : 466 amino acids; 53652 Da
Subunit : Homopolymer assembled from elementary dimers. Interacts with HCV core protein. Interacts with LGSN and SYNM.Interacts (via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with SLC6A4. Interacts with STK33. Interacts with LARP6. Interacts with RAB8B (By similarity)
Subcellular location : Cytoplasm
Sequence caution : Sequence=BAB71275.1; Type=Miscellaneous discrepancy; Note=Intron retention;
6/10 PDB 3D structures from and Proteopedia for VIM (see all 10 ):1GK4 (3D)
  1GK6 (3D)
  1GK7 (3D)
  3G1E (3D)
  3KLT (3D)
  3S4R (3D)
 
Secondary accessions : B0YJC2 D3DRU4 Q15867 Q15868 Q15869 Q548L2 Q6LER9 Q8N850 Q96ML2 Q9NTM3Explore the universe of human proteins at neXtProt for VIM: NX_P08670 Post-translational modifications:
Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK331
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P08670 VIM Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_003371.2 ENSEMBL proteins: ENSP00000224237 ENSP00000435613 ENSP00000431702 ENSP00000391842 ENSP00000446007 Reactome Protein details: P08670 Human Recombinant Protein Products: Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11 ): About this table
VIM for ontologies About GeneDecksing VIM Antibody Products: EMD Millipore Mono- and Polyclonal Antibodies for the study of VIM R&D Systems Antibodies for VIM (Vimentin) Cell Signaling Technology (CST) Antibodies for VIM   (vimentin) OriGene Antibodies (see all 27 ): VIM OriGene Custom Antibody Services for VIM GenScript Superior Antibodies for VIM Novus Biologicals VIM Antibodies Abcam antibodies for VIM Uscn Antibodies for VIM ThermoFisher Antibody for VIM
Assay Products for VIM:
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Protein
Domains / Familiesfor VIM gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
VIM for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P08670 ProtoNet protein and cluster: P08670
1 Blocks protein family : IPB001664 Intermediate filament protein UniProtKB/Swiss-Prot: VIME_HUMAN, P08670 Domain : The central alpha-helical coiled-coil rod region mediates elementary homodimerizationSimilarity : Belongs to the intermediate filament family
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Functionfor VIM gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: VIME_HUMAN, P08670 Function : Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymalcells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally Function : Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2
Genatlas biochemistry entry for VIM : vimentin,intermediate filament protein,expressed in cells of mesenchymal origin,regulated by an antisilencer element Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VIM (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VIMOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: VIM (NM_003380 ) Sino Biological Human cDNA Clone for VIM DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VIM Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VIM
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIM
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8 ): About this table
VIM for ontologies About GeneDecksing 5 GenomeRNAi human phenotypes for VIM :Animal Models: Mouse knock-out Vim tm2Cba for VIM 13 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Vim) :
VIM for phenotypes About GeneDecksing
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Pathways & Interactionsfor VIM gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/14 super-pathways (see all 14 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Apoptotic cleavage of cellular proteins 2 Cytoskeleton remodeling Neurofilaments 3 Striated Muscle Contraction 4 Cytoskeleton remodeling Keratin filaments 5 Cell adhesion Endothelial cell contacts by junctional mechanisms
Pathway sources See GeneCards unified pathways Show all pathways 4 EMD Millipore Pathways for VIM 4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for VIM 1
Cell Signaling Technology (CST) Pathway for VIM 3 GeneGo (Thomson Reuters) Pathways for VIM 5 BioSystems Pathways for VIM 5/6
Reactome Pathways for VIM (see all 6 )
VIM for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VIM STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/1074 Interacting proteins for VIM (P08670 1 , 2 , 3 ENSP00000224237 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 1074 )Interactant Interaction Details GeneCard External ID(s) KAT7 O95251 1 , 2 , 3 , ENSP00000259021 4 EBI-3442369,EBI-473199 MINT-3980250 MINT-64943 MINT-66105 MINT-8277050 I2D:
score=7 STRING: ENSP00000259021 CRMP1 Q14194 1 , 2 , 3 , ENSP00000321606 4 EBI-3442369,EBI-473101 MINT-3980404 MINT-8277004 MINT-3981786 I2D:
score=3 STRING: ENSP00000321606 CHD3 Q12873 2 , 3 , ENSP00000369716 4 MINT-3979536 MINT-7945693 MINT-3980267 I2D:
score=3 STRING: ENSP00000369716 SIRT6 Q8N6T7 2 , 3 , ENSP00000337332 4 MINT-64930 MINT-8270737 I2D:
score=4 STRING: ENSP00000337332 YWHAZ P63104 2 , 3 , ENSP00000309503 4 MINT-3297793 MINT-7899812 I2D:
score=4 STRING: ENSP00000309503
About this table Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006915 apoptotic process
TAS -- GO:0006921 cellular component disassembly involved in execution phase of apoptosis
TAS -- GO:0006928 cellular component movement
TAS 16130169 GO:0010977 negative regulation of neuron projection development
IEA -- GO:0014002 astrocyte development
IEA --
VIM for ontologies About GeneDecksing
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Drugs & Compoundsfor VIM gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
VIM for compounds About GeneDecksing Browse Tocris compounds for VIM 1 HMDB Compound for VIM About this table 10/156 Novoseek chemical compound relationships for VIM gene (see all 156 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
b 723
71.5
37
7868083 (3), 12883236 (3), 12046609 (2), 1376598 (1) (see all 32 )
mucicarmine
71.4
8
16334025 (1), 11858401 (1), 10405240 (1), 8776426 (1) (see all 8 )
paraffin
67.4
66
1693875 (1), 1699393 (1), 2029088 (1), 7524376 (1) (see all 62 )
reticulin
63.7
13
7792953 (1), 11858401 (1), 16713546 (1), 8340101 (1) (see all 11 )
progesterone
62.7
184
19269675 (4), 12090595 (2), 15088145 (2), 11866908 (2) (see all 99 )
estrogen
58.4
180
19269675 (4), 12004356 (3), 15088145 (2), 2153347 (2) (see all 99 )
hematoxylin
56.5
24
7512798 (1), 15049161 (1), 10767834 (1), 16949932 (1) (see all 23 )
matrigel
53.1
9
7528440 (1), 19397698 (1), 11688960 (1), 1793731 (1) (see all 8 )
cp-49
47.7
8
7615661 (3), 7781747 (2), 10627819 (1), 17927688 (1) (see all 5 )
s 100
47.4
7
8878020 (2), 11253140 (1), 11253120 (1), 7706516 (1) (see all 6 )
Search CenterWatch for drugs/clinical trials and news about VIM / VIME
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Transcriptsfor VIM gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for VIM gene: NM_003380.3 Unigene Clusters for VIM:
Vimentin Hs.455493 [show with all ESTs ] , Hs.691131 [show with all ESTs ] Unigene Representative Sequences: NM_003380 , BM458017 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000478317 ENST00000478746 ENST00000497849 ENST00000224237 ENST00000487938 ENST00000485947 ENST00000469543 ENST00000421459 ENST00000495528 ENST00000544301 (uc001iou.2 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VIM (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VIMOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: VIM (NM_003380 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VIM Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VIM
Additional cDNA sequence: X16478.1
24/187 DOTS entries (see all 187 ): DT.100736301 DT.99925994
DT.91733250 DT.95153735 DT.100736262 DT.100736286 DT.97861183 DT.102844050 DT.100894798 DT.100736247 DT.100736370 DT.100736347 DT.100736249 DT.92344625 DT.99926544 DT.85103186 DT.95153671 DT.100736367 DT.97854035 DT.121233616 DT.121233524 DT.100736330 DT.92407751 DT.100736329 24/4539 AceView cDNA sequences (see all 4539 ):
BQ435084 BQ183072 BU617443 BE296541 CB130545 BQ952257 AI826031 BM741719 BF086481 CA397709 BQ877938 BU178982 BU149209 BQ425233 BG165527 BQ773378 BM763352 BQ888990 BI861021 BU740068 CR608699 BM463012 BI871091 BQ917299 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for VIM About this scheme ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 SP1 :   -         -             -         SP2 :                               SP3 :                               SP4 :           -   -                   SP5 :                              
ECgene alternative splicing isoforms for VIM
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Expression for VIM gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section VIM expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCCAAATCGA
About this image VIM expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See VIM Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for VIM SOURCE GeneReport for Unigene clusters: Hs.455493 Hs.691131 UniProtKB/Swiss-Prot: VIME_HUMAN, P08670 Tissue specificity : Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or noexpression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines SABiosciences Expression via Pathway-Focused PCR Arrays including VIM (see all 8 ): Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VIMBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat VIM QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VIM QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VIM In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIM
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Orthologsfor VIM gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for VIM gene from 5/17 species (see all 17 ) About this table
ENSEMBL Gene Tree for VIM (if available)TreeFam Gene Tree for VIM (if available)
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Paralogsfor VIM gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for VIM gene LMNB1 2 SYNM 2 INA 2 LMNA 2 NES 2 PRPH 2 DES 2 NEFM 2 LMNB2 2 NEFH 2 GFAP 2 18/67 SIMAP similar genes for VIM using alignment to 4 protein entries: VIME_HUMAN (see all proteins )
(see all similar genes ):DES tmp_locus_29 PRPH KRTHB6 GFAP DKFZp761K0922 NEFM INA NEFL KRT4 KRTHB1 KRT1 KRT5 keratin KRT76 KRT79 KRT3 KRT6A
VIM for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for VIM PGOHUM00000243352
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Genomic Variantsfor VIM gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for VIM (17270258 - 17279592 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for VIM: -- Human Gene Mutation Database (HGMD) : VIM Locus Specific Mutation Databases (LSDB): VIM SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VIM
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Disorders
/ Diseasesfor VIM gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
VIM for disorders About GeneDecksing
OMIM gene information: 193060
OMIM disorders : --20/376 diseases for VIM (see all 376 ): About MalaCards cataract, pulverulent, autosomal dominant malignant peripheral nerve sheath tumor polymorphous low-grade adenocarcinoma sex cord-gonadal stromal tumor brooke-spiegler syndrome cataract von hippel-lindau disease cataract, pulverulent mesoblastic nephroma persistent hyperinsulinemic hypoglycemia of infancy tay-sachs disease atypical teratoid rhabdoid tumor fibrous histiocytoma infantile digital fibromatosis giant-cell fibroblastoma desmoplastic small round cell tumor lymphoepithelioma-like carcinoma dermatofibrosarcoma protuberans alveolar soft part sarcoma malignant fibrous histiocytoma 20/61 diseases from the University of Copenhagen DISEASES database for VIM (see all 61 ):Carcinoma Sarcoma Essential tremor Mesenchymal cell neoplasm Leiomyosarcoma Carcinosarcoma Meningioma Hemangiopericytoma Malignant fibroxanthoma Germ cell cancer Benign mesothelioma Myoepithelioma Chordoma Glomus tumor Rhabdomyosarcoma Neurilemmoma Synovial sarcoma Granular cell tumor Fibrosarcoma Renal cell carcinoma 10/94 Novoseek disease relationships for VIM gene (see all 94 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tumors
86.2
1864
2153347 (5), 7518849 (5), 18632620 (4), 2173410 (4) (see all 99 )
rhabdoid tumor
83.6
9
15471430 (1), 19432675 (1), 11557780 (1), 8781656 (1) (see all 9 )
myoepithelioma
83.4
11
1694334 (1), 15619979 (1), 15717758 (1), 16099771 (1) (see all 10 )
carcinosarcoma
82
8
1696005 (1), 18281472 (1), 15132766 (1), 1283991 (1) (see all 8 )
sarcoma epithelioid
81
13
7679559 (3), 1689556 (1), 19997734 (1), 12946229 (1) (see all 9 )
sarcoma
80.1
45
1845482 (2), 7692876 (2), 1928559 (1), 1284388 (1) (see all 37 )
myofibroblastoma
78.7
4
10235504 (1), 9805854 (1), 1661895 (1), 1918406 (1)
stromal tumors
78.3
11
7527534 (2), 16550975 (1), 12475434 (1), 14668550 (1) (see all 9 )
carcinoma spindle cell
76.9
6
9872659 (1), 8005741 (1), 2130227 (1), 15897741 (1)
metastasis
76.7
87
18184460 (4), 20460738 (3), 18383865 (3), 15328185 (2) (see all 58 )
Human Genome Epidemiology (HuGE) Navigator: VIM (4 documents) Export disorders for VIM gene to outside databases
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Publicationsfor VIM gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for VIM gene, integrated from 9 sources (see all 2923 ): (articles sorted by number of sources associating them with VIM) Utopia : connect your pdf to the dynamic world of online information
The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. (PubMed id 19270731) 1 , 2 , 9 Ahmed B.A....Kilic F. (2009) Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments. (PubMed id 14762106) 1 , 2 , 9 Eriksson J.E.... Goldman R.D. (2004) SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PubMed id 14996095) 1 , 2 , 9 Hartmann T.B.... Eichmueller S. (2004) Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils. (PubMed id 21465480) 1 , 2 Lee K.Y.... Rosales J.L. (2012) A novel role of vimentin filaments: binding and stabilization of collagen mRNAs. (PubMed id 21746880) 1 , 2 Challa A.A. and Stefanovic B. (2011) Atomic structure of vimentin coil 2. (PubMed id 20176112) 1 , 2 Nicolet S....Strelkov S.V. (2010) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 1 , 2 Rush J.... Comb M.J. (2005) Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein. (PubMed id 15846844) 1 , 2 Kang S.-M.... Oh J.-W. (2005)
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External Searches for VIM gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing VIM gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing VIM gene
(According to HUGE )
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Specialized Databases showing VIM gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for VIM gene: Search GeneIP for patents involving VIM GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor VIM gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for VIM OriGene shRNA RFP for VIM OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for VIM OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VIM OriGene Protein Over-expression Lysate for VIM Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for VIM OriGene 3'-UTR Clone for VIM OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VIM OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VIM Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for VIM OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for VIM OriGene Custom Protein Services for VIM OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VIM QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VIM QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VIM QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat VIM QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VIM QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VIM
Antibodies & Assays for VIM   (vimentin)
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Recombinant Protein for VIM
VIM Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VIM
ThermoFisher Antibody for VIM
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VIM
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