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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VILL Gene

protein-coding   GIFtS: 48
GCID: GC03P038029

Villin-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
villin-like1 2
Villin-Like Protein2
EC 2.2.1.28
EC 6.3.2.68

External Ids:    HGNC: 309061   Entrez Gene: 508532   Ensembl: ENSG000001360597   UniProtKB: O151953   

Export aliases for VILL gene to outside databases

Previous GC identifers: GC03P037339 GC03P037845 GC03P037997 GC03P038013 GC03P037977


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VILL Gene:
The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a
headpiece domain. It may play a role in actin-bundling. (provided by RefSeq, Jul 2008)

GeneCards Summary for VILL Gene: 
VILL (villin-like) is a protein-coding gene. Diseases associated with VILL include typhus, and scrub typhus. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is SVIL.

UniProtKB/Swiss-Prot: VILL_HUMAN, O15195
Function: Possible tumor suppressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VILL gene promoter:
         Max1   GR   USF1   GR-beta   Max   Nkx6-1   USF-1   ARP-1   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVILL promoter sequence
   Search SABiosciences Chromatin IP Primers for VILL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VILL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21

VILL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VILL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P038029:  view genomic region     (about GC identifiers)

Start:
38,029,550 bp from pter      End:
38,048,679 bp from pter
Size:
19,130 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VILL_HUMAN, O15195 (See protein sequence)
Recommended Name: Villin-like protein  
Size: 856 amino acids; 95907 Da
Sequence caution: Sequence=AAH00243.1; Type=Erroneous initiation; Sequence=AAH04300.1; Type=Erroneous initiation;
Secondary accessions: A8MZP1 Q9BT80 Q9BWH7
Alternative splicing: 2 isoforms:  O15195-1   O15195-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VILL: NX_O15195

Explore proteomics data for VILL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15195

  • 2 DME Specific Peptides for VILL (O15195)
     KEAVAWG  LPEGVDP 

    VILL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VILL Protein Expression
    REFSEQ proteins: NP_056957.3  
    ENSEMBL proteins: 
     ENSP00000283713   ENSP00000393661   ENSP00000427355   ENSP00000422096   ENSP00000387659  
     ENSP00000373266  

    Human Recombinant Protein Products for VILL: 
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    Cloud-Clone Corp. Proteins for VILL 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015629actin cytoskeleton TAS9179494

    VILL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR015626 Villin-like
     IPR007122 Villin/Gelsolin
     IPR003128 Villin_headpiece
     IPR007123 Gelsolin_dom

    Graphical View of Domain Structure for InterPro Entry O15195

    ProtoNet protein and cluster: O15195

    4 Blocks protein domains:
    IPB001199 Cytochrome b5
    IPB003128 Villin headpiece
    IPB007122 Gelsolin family signature
    IPB007123 Gelsolin region


    UniProtKB/Swiss-Prot: VILL_HUMAN, O15195
    Similarity: Belongs to the villin/gelsolin family
    Similarity: Contains 6 gelsolin-like repeats
    Similarity: Contains 1 HP (headpiece) domain


    VILL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VILL_HUMAN, O15195
    Function: Possible tumor suppressor

         Genatlas biochemistry entry for VILL:
    Villin-like

         Enzyme Numbers (IUBMB): EC 2.2.1.22 EC 6.3.2.62

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005200structural constituent of cytoskeleton TAS9179494
         
    VILL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for VILL 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VILL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VILL 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VILL

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IEA--
    GO:0051693actin filament capping IEA--

    VILL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VILL

    Search CenterWatch for drugs/clinical trials and news about VILL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VILL gene: 
    NM_015873.3  

    Unigene Cluster for VILL:

    Villin-like
    Hs.103665  [show with all ESTs]
    Unigene Representative Sequence: BC004300
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283713(uc003chj.3) ENST00000416303 ENST00000492491 ENST00000460040
    ENST00000484717(uc010hgu.3) ENST00000465644 ENST00000412008 ENST00000463080
    ENST00000486616 ENST00000488209 ENST00000383759(uc003chk.1 uc003chl.3)

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VILL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VILL
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    Additional mRNA sequence: 

    AK309304.1 BC000243.1 BC004300.1 D88154.1 

    7 DOTS entries:

    DT.308947  DT.102823312  DT.95366465  DT.95310672  DT.91749545  DT.95183565  DT.97839913 

    24/62 AceView cDNA sequences (see all 62):

    BU689745 CR591344 BC000243 CA433458 BC004300 AL551271 BM714810 AA641469 
    AA992660 CF131450 BE615005 AL702875 BM837100 BE256745 BI825678 BX382952 
    BU739711 BX334020 BU689742 AI004782 BM906462 BM673528 AX810712 AX810726 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VILL (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b
    SP1:                                                        -           -                             -                             -                     
    SP2:                                                                                                                                                      
    SP3:                                                        -                                                                                             
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for VILL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VILL expression in normal human tissues (normalized intensities)      VILL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACGTGGA
    VILL Expression
    About this image


    VILL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Blood (Hematopoietic System)
             c-kit+ gr1+ mac1- myeloblasts   

    See VILL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VILL

    SOURCE GeneReport for Unigene cluster: Hs.103665

    UniProtKB/Swiss-Prot: VILL_HUMAN, O15195
    Tissue specificity: Ubiquitously expressed in 16 tissues examined

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for VILL gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vill1 , 5 villin-like1, 5 79.94(n)1
    72.37(a)1
      9 (71.32 cM)5
    223511  NM_001164567.11  NP_001158039.11 
     1190527785 
    chicken
    (Gallus gallus)
    Aves VILL1 villin-like 65.22(n)
    59.62(a)
      420415  XM_418521.2  XP_418521.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gel6
    qua6
    quail
    26(a)
    22(a)
    1 ↔ many
    possible ortholog
    3R(60868-66780)
    2L(17486806-17497203)
    worm
    (Caenorhabditis elegans)
    Secernentea gsnl-16
    Gelsolin-like protein 1
    30(a)
    1 → many
    V(9497051-9499378)


    ENSEMBL Gene Tree for VILL (if available)
    TreeFam Gene Tree for VILL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for VILL gene
    SVIL2  FLII2  AVIL2  SCIN2  GSN2  CAPG2  VIL12  
    7 SIMAP similar genes for VILL using alignment to 5 protein entries:     VILL_HUMAN (see all proteins):
    DKFZp313L0718    VIL1    AVIL    SVIL    GSN    SCIN
    CAPG

    VILL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/489 SNPs in VILL are shown (see all 489)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868235881,2
    --38033090(+) GAGAAA/GGGGAA 1 -- us2k10--------
    rs1896336141,2
    --38033246(+) TCCCCA/TGAGGA 1 -- us2k10--------
    rs1123531921,2
    C,F--38033325(+) GAGGGC/TTTGGG 1 -- us2k12Minor allele frequency- T:0.50NA CSA 4
    rs1834066131,2
    C--38033346(+) TGGCAA/CTGTGG 1 -- us2k10--------
    rs1181011871,2
    F--38033370(+) CCCCAA/GTCTTT 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs98728041,2
    C,F,A--38033462(+) GAGGGC/TTTGGC 1 -- us2k19Minor allele frequency- T:0.32WA NA CSA EA 368
    rs1386061381,2
    C--38033473(+) TCTACA/GGGCTG 1 -- us2k10--------
    rs1878186391,2
    --38033509(+) GACCCC/TTGGGG 1 -- us2k10--------
    rs1923085511,2
    --38033515(+) TGGGGG/TCGATG 1 -- us2k10--------
    rs730608051,2
    C,F--38033516(+) GGGGGC/TGATGC 1 -- us2k14Minor allele frequency- T:0.08NA CSA WA 242

    HapMap Linkage Disequilibrium report for VILL (38029550 - 38048679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VILL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428416CNV Loss18775914
    nsv522354CNV Loss19592680
    dgv1448e1CNV Complex17122850
    dgv1447e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for VILL:    About MalaCards
    typhus    scrub typhus    gastric cancer


    VILL for disorders           About GeneDecksing


    Export disorders for VILL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VILL gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with VILL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PubMed id 9179494)1, 2, 3 Ishikawa S.... Nakamura Y. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PubMed id 18022635)1 Piana S....Martins J.C. (2008)
    4. Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. (PubMed id 18006815)1 Yamamichi N....Iba H. (2007)
    5. Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration. (PubMed id 16921170)1 Tomar A....Khurana S. (2006)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. The villin-like protein encoded by the Drosophila qua il gene is required for actin bundle assembly during oogenesis. (PubMed id 8044841)9 Mahajan-Miklos S. and Cooley L. (1994)
    9. Villidin, a novel WD-repeat and villin-related protein from Dictyostelium, is associated with membranes and the cytoskeleton. (PubMed id 12857859)9 Gloss A....Noegel A.A. (2003)
    10. Drosophila fascin mutants are rescued by overexpression of the villin-like protein, quail. (PubMed id 9405306)9 Cant K....Cooley L. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50853 HGNC: 30906 AceView: VILL Ensembl:ENSG00000136059 euGenes: HUgn50853
    ECgene: VILL H-InvDB: VILL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VILL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VILL gene:
    Search GeneIP for patents involving VILL

    GeneCards and IP:
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