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Aliases for VILL Gene

Aliases for VILL Gene

  • Villin-Like 2 3 5
  • EC 63
  • EC 63

External Ids for VILL Gene

Previous GeneCards Identifiers for VILL Gene

  • GC03P037339
  • GC03P037845
  • GC03P037997
  • GC03P038013
  • GC03P037977
  • GC03P038029

Summaries for VILL Gene

Entrez Gene Summary for VILL Gene

  • The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]

GeneCards Summary for VILL Gene

VILL (Villin-Like) is a Protein Coding gene. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is VIL1.

UniProtKB/Swiss-Prot for VILL Gene

  • Possible tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VILL Gene

Genomics for VILL Gene

Regulatory Elements for VILL Gene

Enhancers for VILL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VILL on UCSC Golden Path with GeneCards custom track

Genomic Location for VILL Gene

37,987,975 bp from pter
38,007,188 bp from pter
19,214 bases
Plus strand

Genomic View for VILL Gene

Genes around VILL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VILL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VILL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VILL Gene

Proteins for VILL Gene

  • Protein details for VILL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Villin-like protein
    Protein Accession:
    Secondary Accessions:
    • A8MZP1
    • Q9BT80
    • Q9BWH7

    Protein attributes for VILL Gene

    856 amino acids
    Molecular mass:
    95907 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00243.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH04300.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VILL Gene


neXtProt entry for VILL Gene

Proteomics data for VILL Gene at MOPED

Selected DME Specific Peptides for VILL Gene

Post-translational modifications for VILL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VILL Gene

Domains & Families for VILL Gene

Gene Families for VILL Gene

Suggested Antigen Peptide Sequences for VILL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HP (headpiece) domain.
  • Belongs to the villin/gelsolin family.
  • Contains 6 gelsolin-like repeats.
  • Contains 1 HP (headpiece) domain.
  • Belongs to the villin/gelsolin family.
  • Contains 6 gelsolin-like repeats.
genes like me logo Genes that share domains with VILL: view

Function for VILL Gene

Molecular function for VILL Gene

GENATLAS Biochemistry:
UniProtKB/Swiss-Prot Function:
Possible tumor suppressor.

Enzyme Numbers (IUBMB) for VILL Gene

genes like me logo Genes that share phenotypes with VILL: view

Animal Model Products

miRNA for VILL Gene

miRTarBase miRNAs that target VILL

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VILL Gene

Localization for VILL Gene

Subcellular locations from

Jensen Localization Image for VILL Gene COMPARTMENTS Subcellular localization image for VILL gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for VILL Gene

Pathways & Interactions for VILL Gene

SuperPathways for VILL Gene

No Data Available

Interacting Proteins for VILL Gene

Gene Ontology (GO) - Biological Process for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with VILL: view

No data available for Pathways by source and SIGNOR curated interactions for VILL Gene

Drugs & Compounds for VILL Gene

No Compound Related Data Available

Transcripts for VILL Gene

Unigene Clusters for VILL Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VILL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP3: -
SP6: -

Relevant External Links for VILL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VILL Gene

mRNA expression in normal human tissues for VILL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VILL Gene

This gene is overexpressed in Colon - Transverse (x6.1) and Stomach (x4.8).

Protein differential expression in normal tissues from HIPED for VILL Gene

This gene is overexpressed in Stomach (48.5) and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VILL Gene

SOURCE GeneReport for Unigene cluster for VILL Gene Hs.103665

mRNA Expression by UniProt/SwissProt for VILL Gene

Tissue specificity: Ubiquitously expressed in 16 tissues examined.
genes like me logo Genes that share expression patterns with VILL: view

Primer Products

No data available for Protein tissue co-expression partners for VILL Gene

Orthologs for VILL Gene

This gene was present in the common ancestor of animals.

Orthologs for VILL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia VILL 35
  • 83.31 (n)
  • 75.09 (a)
  • 72 (a)
(Canis familiaris)
Mammalia VILL 35
  • 80.7 (n)
  • 72.74 (a)
  • 71 (a)
(Mus musculus)
Mammalia Vill 35
  • 79.94 (n)
  • 72.25 (a)
Vill 16
Vill 36
  • 72 (a)
(Pan troglodytes)
Mammalia VILL 35
  • 93.41 (n)
  • 90.76 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Vill 35
  • 80.66 (n)
  • 73.74 (a)
(Ornithorhynchus anatinus)
Mammalia VILL 36
  • 35 (a)
(Gallus gallus)
Aves VILL 35
  • 64.67 (n)
  • 59.16 (a)
(Danio rerio)
Actinopterygii si:dkeyp-57f11.2 36
  • 11 (a)
fruit fly
(Drosophila melanogaster)
Insecta qua 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea gsnl-1 36
  • 32 (a)
Species with no ortholog for VILL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for VILL Gene

Gene Tree for VILL (if available)
Gene Tree for VILL (if available)

Paralogs for VILL Gene

Paralogs for VILL Gene

(7) SIMAP similar genes for VILL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with VILL: view

Variants for VILL Gene

Sequence variations from dbSNP and Humsavar for VILL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1892814 - 38,004,279(+) AGCTT(C/G)CAGCC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs9816693 - 38,006,463(+) AACTT(C/G)CGGCT nc-transcript-variant, reference, missense
rs1962765 -- 38,002,964(+) TGCGG(A/G)GTCCC intron-variant
rs2364781 -- 38,006,542(+) GCTCA(G/T)ATAAT nc-transcript-variant, reference, stop-gained
rs2364782 -- 38,006,544(+) TCATA(A/G/T)AATGA nc-transcript-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for VILL Gene

Variant ID Type Subtype PubMed ID
dgv1447e1 CNV Complex 17122850
dgv1448e1 CNV Complex 17122850
nsv428416 CNV Loss 18775914
nsv522354 CNV Loss 19592680

Variation tolerance for VILL Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.92; 83.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VILL Gene

Disorders for VILL Gene

Relevant External Links for VILL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VILL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VILL Gene

Publications for VILL Gene

  1. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PMID: 9179494) Ishikawa S. … Nakamura Y. (DNA Res. 1997) 2 3 4 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PMID: 18022635) Piana S. … Martins J.C. (J. Mol. Biol. 2008) 3
  4. Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. (PMID: 18006815) Yamamichi N. … Iba H. (Cancer Res. 2007) 3
  5. Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration. (PMID: 16921170) Tomar A. … Khurana S. (J. Biol. Chem. 2006) 3

Products for VILL Gene

Sources for VILL Gene