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Aliases for VILL Gene

Aliases for VILL Gene

  • Villin Like 2 3 5
  • EC 56
  • EC 56

External Ids for VILL Gene

Previous GeneCards Identifiers for VILL Gene

  • GC03P037339
  • GC03P037845
  • GC03P037997
  • GC03P038013
  • GC03P037977
  • GC03P038029

Summaries for VILL Gene

Entrez Gene Summary for VILL Gene

  • The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]

GeneCards Summary for VILL Gene

VILL (Villin Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is VIL1.

UniProtKB/Swiss-Prot for VILL Gene

  • Possible tumor suppressor.

Additional gene information for VILL Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VILL Gene

Genomics for VILL Gene

GeneHancer (GH) Regulatory Elements for VILL Gene

Promoters and enhancers for VILL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I037984 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 569 +4.2 4156 15.1 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A VILL C3orf35 CTDSPL OXSR1 ITGA9-AS1 GC03P038014
GH03I038001 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +16.0 15975 4.7 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A ZNF2 IRF4 ZNF207 VILL ENSG00000271653 ITGA9-AS1 SLC22A14 GC03P038014
GH03I037859 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 -126.0 -125955 4.6 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SP5 NFYC CTDSPL ITGA9-AS1 VILL GC03P037965
GH03I037961 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.3 -24.4 -24440 4.7 FOXA2 ARID4B THRB RAD21 RARA YY1 CREM THAP11 MIXL1 KLF11 VILL CTDSPL ITGA9-AS1 GC03P037965
GH03I038163 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.7 +179.2 179223 8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 OXSR1 LOC101928234 GORASP1 NDUFAF4P3 ACAA1 MYD88 ACVR2B C3orf35 SLC22A13 ACVR2B-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VILL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VILL gene promoter:

Genomic Locations for VILL Gene

Genomic Locations for VILL Gene
19,214 bases
Plus strand

Genomic View for VILL Gene

Genes around VILL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VILL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VILL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VILL Gene

Proteins for VILL Gene

  • Protein details for VILL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Villin-like protein
    Protein Accession:
    Secondary Accessions:
    • A8MZP1
    • Q9BT80
    • Q9BWH7

    Protein attributes for VILL Gene

    856 amino acids
    Molecular mass:
    95907 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00243.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH04300.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VILL Gene


neXtProt entry for VILL Gene

Selected DME Specific Peptides for VILL Gene


Post-translational modifications for VILL Gene

No Post-translational modifications

Domains & Families for VILL Gene

Gene Families for VILL Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for VILL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the villin/gelsolin family.
  • Belongs to the villin/gelsolin family.
genes like me logo Genes that share domains with VILL: view

Function for VILL Gene

Molecular function for VILL Gene

GENATLAS Biochemistry:
UniProtKB/Swiss-Prot Function:
Possible tumor suppressor.

Enzyme Numbers (IUBMB) for VILL Gene

Phenotypes From GWAS Catalog for VILL Gene

Gene Ontology (GO) - Molecular Function for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 9179494
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with VILL: view
genes like me logo Genes that share phenotypes with VILL: view

miRNA for VILL Gene

miRTarBase miRNAs that target VILL

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VILL Gene

Localization for VILL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VILL gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton TAS 9179494
genes like me logo Genes that share ontologies with VILL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for VILL Gene

Pathways & Interactions for VILL Gene

No Data Available

Gene Ontology (GO) - Biological Process for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0051693 actin filament capping IEA --
genes like me logo Genes that share ontologies with VILL: view

No data available for Pathways by source and SIGNOR curated interactions for VILL Gene

Drugs & Compounds for VILL Gene

No Compound Related Data Available

Transcripts for VILL Gene

Unigene Clusters for VILL Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VILL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP3: -
SP6: -

Relevant External Links for VILL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VILL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VILL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VILL Gene

This gene is overexpressed in Colon - Transverse (x6.1) and Stomach (x4.8).

Protein differential expression in normal tissues from HIPED for VILL Gene

This gene is overexpressed in Stomach (48.5) and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VILL Gene

NURSA nuclear receptor signaling pathways regulating expression of VILL Gene:


SOURCE GeneReport for Unigene cluster for VILL Gene:


mRNA Expression by UniProt/SwissProt for VILL Gene:

Tissue specificity: Ubiquitously expressed in 16 tissues examined.

Evidence on tissue expression from TISSUES for VILL Gene

  • Lung(4.2)
  • Pancreas(4.2)
  • Nervous system(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with VILL: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VILL Gene

Orthologs for VILL Gene

This gene was present in the common ancestor of animals.

Orthologs for VILL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VILL 33 34
  • 93.41 (n)
(Bos Taurus)
Mammalia VILL 33 34
  • 83.31 (n)
(Canis familiaris)
Mammalia VILL 33 34
  • 80.7 (n)
(Rattus norvegicus)
Mammalia Vill 33
  • 80.66 (n)
(Mus musculus)
Mammalia Vill 33 16 34
  • 79.94 (n)
(Ornithorhynchus anatinus)
Mammalia VILL 34
  • 35 (a)
(Gallus gallus)
Aves VILL 33
  • 64.67 (n)
(Danio rerio)
Actinopterygii si:dkeyp-57f11.2 34
  • 11 (a)
fruit fly
(Drosophila melanogaster)
Insecta qua 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea gsnl-1 34
  • 32 (a)
Species where no ortholog for VILL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for VILL Gene

Gene Tree for VILL (if available)
Gene Tree for VILL (if available)

Paralogs for VILL Gene

Paralogs for VILL Gene

(7) SIMAP similar genes for VILL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with VILL: view

Variants for VILL Gene

Sequence variations from dbSNP and Humsavar for VILL Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000138794 -- 37,995,397(+) C/T intron_variant
rs1000224253 -- 38,004,628(+) G/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000355847 -- 37,998,886(+) A/G intron_variant
rs1000487286 -- 37,992,145(+) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000810317 -- 37,998,634(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VILL Gene

Variant ID Type Subtype PubMed ID
esv2759140 CNV loss 17122850
nsv428416 CNV loss 18775914
nsv522354 CNV loss 19592680
nsv590094 CNV loss 21841781
nsv590101 CNV loss 21841781

Variation tolerance for VILL Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.92; 83.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VILL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VILL Gene

Disorders for VILL Gene

Additional Disease Information for VILL

No disorders were found for VILL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VILL Gene

Publications for VILL Gene

  1. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PMID: 9179494) Ishikawa S … Nakamura Y (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
  5. Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PMID: 18022635) Piana S … Martins JC (Journal of molecular biology 2008) 3 58

Products for VILL Gene

Sources for VILL Gene

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