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Aliases for VILL Gene

Aliases for VILL Gene

  • Villin Like 2 3 5
  • EC 61
  • EC 61

External Ids for VILL Gene

Previous GeneCards Identifiers for VILL Gene

  • GC03P037339
  • GC03P037845
  • GC03P037997
  • GC03P038013
  • GC03P037977
  • GC03P038029

Summaries for VILL Gene

Entrez Gene Summary for VILL Gene

  • The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]

GeneCards Summary for VILL Gene

VILL (Villin Like) is a Protein Coding gene. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is VIL1.

UniProtKB/Swiss-Prot for VILL Gene

  • Possible tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VILL Gene

Genomics for VILL Gene

Regulatory Elements for VILL Gene

Enhancers for VILL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F038001 1.6 FANTOM5 Ensembl ENCODE 18.5 +18.6 18589 9.9 HDGF ATF1 PKNOX1 MLX WRNIP1 ZNF133 ARID4B SIN3A ZNF48 ZNF2 OXSR1 VILL SLC22A14 GC03P038014
GH03F037984 1.4 Ensembl ENCODE 19 +4.2 4157 15.1 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A CBX5 ZNF207 VILL CTDSPL ITGA9-AS1 GC03P038014
GH03F037961 1.3 Ensembl ENCODE 20.3 -24.4 -24441 4.7 HDGF PKNOX1 ATF1 ARNT ZNF133 ARID4B SIN3A ZNF2 ZNF48 YY1 VILL CTDSPL ITGA9-AS1 RPL29P11 GC03P037965
GH03F037955 1.3 Ensembl ENCODE 19.4 -31.3 -31275 2.6 HDGF ATF1 PKNOX1 ARNT SIN3A GATA2 ZNF143 FOS REST TBX21 VILL CTDSPL ITGA9-AS1 GC03P037965
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VILL on UCSC Golden Path with GeneCards custom track

Genomic Location for VILL Gene

37,987,975 bp from pter
38,007,188 bp from pter
19,214 bases
Plus strand

Genomic View for VILL Gene

Genes around VILL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VILL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VILL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VILL Gene

Proteins for VILL Gene

  • Protein details for VILL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Villin-like protein
    Protein Accession:
    Secondary Accessions:
    • A8MZP1
    • Q9BT80
    • Q9BWH7

    Protein attributes for VILL Gene

    856 amino acids
    Molecular mass:
    95907 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00243.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH04300.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VILL Gene


neXtProt entry for VILL Gene

Selected DME Specific Peptides for VILL Gene


Post-translational modifications for VILL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for VILL Gene

Gene Families for VILL Gene

Suggested Antigen Peptide Sequences for VILL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HP (headpiece) domain.
  • Belongs to the villin/gelsolin family.
  • Contains 6 gelsolin-like repeats.
  • Contains 1 HP (headpiece) domain.
  • Belongs to the villin/gelsolin family.
  • Contains 6 gelsolin-like repeats.
genes like me logo Genes that share domains with VILL: view

Function for VILL Gene

Molecular function for VILL Gene

GENATLAS Biochemistry:
UniProtKB/Swiss-Prot Function:
Possible tumor suppressor.

Enzyme Numbers (IUBMB) for VILL Gene

Gene Ontology (GO) - Molecular Function for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004872 receptor activity TAS --
GO:0005003 ephrin receptor activity IEA --
GO:0005200 structural constituent of cytoskeleton TAS 9179494
genes like me logo Genes that share ontologies with VILL: view
genes like me logo Genes that share phenotypes with VILL: view

Animal Model Products

miRNA for VILL Gene

miRTarBase miRNAs that target VILL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VILL Gene

Localization for VILL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VILL gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0015629 actin cytoskeleton TAS 9179494
genes like me logo Genes that share ontologies with VILL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VILL Gene

Pathways & Interactions for VILL Gene

No Data Available

Gene Ontology (GO) - Biological Process for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0048013 ephrin receptor signaling pathway IEA --
GO:0051693 actin filament capping IEA --
genes like me logo Genes that share ontologies with VILL: view

No data available for Pathways by source and SIGNOR curated interactions for VILL Gene

Transcripts for VILL Gene

Unigene Clusters for VILL Gene

Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VILL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP3: -
SP6: -

Relevant External Links for VILL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VILL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VILL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VILL Gene

This gene is overexpressed in Colon - Transverse (x6.1) and Stomach (x4.8).

Protein differential expression in normal tissues from HIPED for VILL Gene

This gene is overexpressed in Stomach (48.5) and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VILL Gene

NURSA nuclear receptor signaling pathways regulating expression of VILL Gene:


SOURCE GeneReport for Unigene cluster for VILL Gene:


mRNA Expression by UniProt/SwissProt for VILL Gene:

Tissue specificity: Ubiquitously expressed in 16 tissues examined.
genes like me logo Genes that share expression patterns with VILL: view

Primer Products

No data available for Protein tissue co-expression partners for VILL Gene

Orthologs for VILL Gene

This gene was present in the common ancestor of animals.

Orthologs for VILL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VILL 34 35
  • 93.41 (n)
(Bos Taurus)
Mammalia VILL 34 35
  • 83.31 (n)
(Canis familiaris)
Mammalia VILL 34 35
  • 80.7 (n)
(Rattus norvegicus)
Mammalia Vill 34
  • 80.66 (n)
(Mus musculus)
Mammalia Vill 34 16 35
  • 79.94 (n)
(Ornithorhynchus anatinus)
Mammalia VILL 35
  • 35 (a)
(Gallus gallus)
Aves VILL 34
  • 64.67 (n)
(Danio rerio)
Actinopterygii si:dkeyp-57f11.2 35
  • 11 (a)
fruit fly
(Drosophila melanogaster)
Insecta qua 35
  • 25 (a)
(Caenorhabditis elegans)
Secernentea gsnl-1 35
  • 32 (a)
Species where no ortholog for VILL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for VILL Gene

Gene Tree for VILL (if available)
Gene Tree for VILL (if available)

Paralogs for VILL Gene

(7) SIMAP similar genes for VILL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with VILL: view

Variants for VILL Gene

Sequence variations from dbSNP and Humsavar for VILL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1052744 -- 38,007,049(+) GGCTT(C/T)TTCTG nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs1052745 -- 38,007,052(+) TTCTT(C/T)TGAAC nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs111227124 -- 37,987,677(+) TCATG(-/C)GCCCC upstream-variant-2KB
rs111287866 -- 37,999,163(+) GAGGG(A/G)GCGGG intron-variant
rs11129776 -- 37,987,184(+) ACTTG(A/C)TGAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VILL Gene

Variant ID Type Subtype PubMed ID
nsv590101 CNV loss 21841781
nsv590094 CNV loss 21841781
nsv522354 CNV loss 19592680
nsv428416 CNV loss 18775914
esv2759140 CNV loss 17122850

Variation tolerance for VILL Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.92; 83.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VILL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VILL Gene

Disorders for VILL Gene

Relevant External Links for VILL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VILL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VILL Gene

Publications for VILL Gene

  1. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PMID: 9179494) Ishikawa S. … Nakamura Y. (DNA Res. 1997) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
  4. Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PMID: 18022635) Piana S. … Martins J.C. (J. Mol. Biol. 2008) 3 64
  5. Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. (PMID: 18006815) Yamamichi N. … Iba H. (Cancer Res. 2007) 3 64

Products for VILL Gene

Sources for VILL Gene

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