VILL Gene
protein-coding GIFtS : 47
GCID: GC03 P038029
villin-like
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Aliasesfor VILL gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Villin-Like 1 Villin-Like Protein2 EC 2.2.1.28 EC 6.3.2.68
Export aliases for VILL gene to outside databases Previous GC identifers: GC03P037339 GC03P037845 GC03P037997 GC03P038013 GC03P037977
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Summariesfor VILL gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for VILL : The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: VILL_HUMAN, O15195 Function : Possible tumor suppressor
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Genomic Viewsfor VILL gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the VILL gene promoter: Max1 GR USF1 GR-beta Max Nkx6-1 USF-1 ARP-1 GR-alpha c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for VILL Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VILL
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p21 VILL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P038029: view genomic region
(about GC identifiers )
Start:
38,029,550 bp from pter
End:
38,048,679 bp from pter
Size:
19,130 bases
Orientation:
plus strand
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Proteinsfor VILL gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: VILL_HUMAN, O15195 (See
protein sequence )Recommended Name: Villin-like protein Size : 856 amino acids; 95907 Da
Sequence caution : Sequence=AAH00243.1; Type=Erroneous initiation; Sequence=AAH04300.1; Type=Erroneous initiation;
Secondary accessions : A8MZP1 Q9BT80 Q9BWH7Alternative splicing : 2 isoforms : O15195-1 O15195-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for VILL: NX_O15195 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O15195 2 DME Specific Peptides for VILL (O15195 ) VILL Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_056957.3 ENSEMBL proteins: ENSP00000283713 ENSP00000393661 ENSP00000427355 ENSP00000422096 ENSP00000387659 ENSP00000373266 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
VILL for ontologies About GeneDecksing VILL Antibody Products: Assay Products for VILL:
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Protein
Domains / Familiesfor VILL gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
VILL for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O15195 ProtoNet protein and cluster: O15195
4 Blocks protein families : IPB001199 Cytochrome b5 IPB003128 Villin headpiece IPB007122 Gelsolin family signature IPB007123 Gelsolin region UniProtKB/Swiss-Prot: VILL_HUMAN, O15195 Similarity : Belongs to the villin/gelsolin familySimilarity : Contains 6 gelsolin-like repeatsSimilarity : Contains 1 HP (headpiece) domain
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Functionfor VILL gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: VILL_HUMAN, O15195 Function : Possible tumor suppressor
Genatlas biochemistry entry for VILL : Villin-like Enzyme Numbers (IUBMB): EC 2.2.1.2 2 EC 6.3.2.6 2 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VILL (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VILL (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: VILL (NM_015873 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VILL Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VILL
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VILL
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
VILL for ontologies About GeneDecksing
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Pathways & Interactionsfor VILL gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VILL Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007010 cytoskeleton organization
IEA -- GO:0051693 actin filament capping
IEA --
VILL for ontologies About GeneDecksing
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Drugs & Compoundsfor VILL gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for VILL Search CenterWatch for drugs/clinical trials and news about VILL
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Transcriptsfor VILL gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for VILL gene: NM_015873.3 Unigene Cluster for VILL:
Villin-like Hs.103665 [show with all ESTs ] Unigene Representative Sequence: BC004300 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000283713 (uc003chj.3 ) ENST00000416303 ENST00000492491 ENST00000460040 ENST00000484717 (uc010hgu.3 ) ENST00000465644 ENST00000412008 ENST00000463080 ENST00000486616 ENST00000488209 ENST00000383759 (uc003chk.1 uc003chl.3 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VILL (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VILL (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: VILL (NM_015873 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VILL Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VILL
Additional cDNA sequence: AK309304.1 BC000243.1 BC004300.1 D88154.1
7 DOTS entries : DT.308947 DT.102823312
DT.95366465 DT.95310672 DT.91749545 DT.95183565 DT.97839913 24/62 AceView cDNA sequences (see all 62 ):
CR591344 BU689745 CA433458 BC004300 BE615005 BC000243 AA641469 CF131450 BM714810 AA992660 AL551271 NM_015873 BM818998 AI004782 BM981806 BX370275 AX810726 BM906462 AI207789 BQ478235 AX810712 BM560282 AL574902 BE256745 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VILL (see all 6 ) About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b SP1 :                   -     -           -           -         SP2 :                                                   SP3 :                   -                                 SP4 :                                                   SP5 :                                                  
ECgene alternative splicing isoforms for VILL
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Expression for VILL gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section VILL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCACGTGGA
About this image VILL expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Gut Tube Midgut Midgut Endoderm Cells Endoderm Gut Tube Midgut Gut Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See VILL Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for VILL SOURCE GeneReport for Unigene cluster: Hs.103665 UniProtKB/Swiss-Prot: VILL_HUMAN, O15195 Tissue specificity : Ubiquitously expressed in 16 tissues examined SABiosciences Custom PCR Arrays for VILL Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VILLBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat VILL QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VILL QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VILL In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VILL
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Orthologsfor VILL gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for VILL gene from 7/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for VILL (if available)TreeFam Gene Tree for VILL (if available)
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Paralogsfor VILL gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for VILL gene SVIL 2 FLII 2 AVIL 2 SCIN 2 GSN 2 VIL1 2 CAPG 2 7 SIMAP similar genes for VILL using alignment to 5 protein entries: VILL_HUMAN (see all proteins ):DKFZp313L0718 VIL1 AVIL SVIL GSN SCIN CAPG
VILL for paralogs About GeneDecksing
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Genomic Variantsfor VILL gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for VILL (38029550 - 38048679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for VILL 1 CNV : 3425
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VILL
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Disorders
/ Diseasesfor VILL gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
VILL for disorders About GeneDecksing 5 diseases for VILL : About MalaCards scrub typhus typhus gastric cancer lung carcinoma carcinoma Export disorders for VILL gene to outside databases
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Publicationsfor VILL gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for VILL gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with VILL) Utopia : connect your pdf to the dynamic world of online information
Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PubMed id 9179494) 1 , 2 , 3 Ishikawa S.... Nakamura Y. (1997) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PubMed id 18022635) 1 Piana S....Martins J.C. (2008) Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. (PubMed id 18006815) 1 Yamamichi N....Iba H. (2007) Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration. (PubMed id 16921170) 1 Tomar A....Khurana S. (2006) The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997) 2 Muzny D.M....Gibbs R.A. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) The villin-like protein encoded by the Drosophila qua il gene is required for actin bundle assembly during oogenesis. (PubMed id 8044841) 9 Mahajan-Miklos S. and Cooley L. (1994) Villidin, a novel WD-repeat and villin-related protein from Dictyostelium, is associated with membranes and the cytoskeleton. (PubMed id 12857859) 9 Gloss A....Noegel A.A. (2003) Drosophila fascin mutants are rescued by overexpression of the villin-like protein, quail. (PubMed id 9405306) 9 Cant K....Cooley L. (1998)
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External Searches for VILL gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing VILL gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing VILL gene
(According to HUGE )
About This Section --
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Specialized Databases showing VILL gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for VILL Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for VILL gene: Search GeneIP for patents involving VILL GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor VILL gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for VILL OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for VILL OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for VILL OriGene Protein Over-expression Lysate for VILL Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for VILL OriGene 3'-UTR Clone for VILL OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for VILL OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for VILL Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for VILL OriGene Custom Protein Services for VILL OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VILL QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing VILL QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat VILL QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat VILL QIAGEN QuantiFast Probe-based Assays in human , mouse , rat VILL QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat VILL
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VILL Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VILL
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat VILL
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