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Aliases for VILL Gene

Aliases for VILL Gene

  • Villin-Like 2 3
  • EC 63
  • EC 63

External Ids for VILL Gene

Previous GeneCards Identifiers for VILL Gene

  • GC03P037339
  • GC03P037845
  • GC03P037997
  • GC03P038013
  • GC03P037977
  • GC03P038029

Summaries for VILL Gene

Entrez Gene Summary for VILL Gene

  • The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]

GeneCards Summary for VILL Gene

VILL (Villin-Like) is a Protein Coding gene. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is AVIL.

UniProtKB/Swiss-Prot for VILL Gene

  • Possible tumor suppressor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VILL Gene

Genomics for VILL Gene

Regulatory Elements for VILL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VILL Gene

37,988,059 bp from pter
38,007,188 bp from pter
19,130 bases
Plus strand

Genomic View for VILL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VILL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VILL Gene

Proteins for VILL Gene

  • Protein details for VILL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Villin-like protein
    Protein Accession:
    Secondary Accessions:
    • A8MZP1
    • Q9BT80
    • Q9BWH7

    Protein attributes for VILL Gene

    856 amino acids
    Molecular mass:
    95907 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00243.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH04300.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VILL Gene


neXtProt entry for VILL Gene

Proteomics data for VILL Gene at MOPED

Selected DME Specific Peptides for VILL Gene

Post-translational modifications for VILL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VILL Gene

Domains for VILL Gene

Suggested Antigen Peptide Sequences for VILL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O15195
  • Contains 1 HP (headpiece) domain.
  • Belongs to the villin/gelsolin family.
  • Contains 6 gelsolin-like repeats.
genes like me logo Genes that share domains with VILL: view

No data available for Gene Families for VILL Gene

Function for VILL Gene

Molecular function for VILL Gene

GENATLAS Biochemistry: Villin-like
UniProtKB/Swiss-Prot Function: Possible tumor suppressor

Enzyme Numbers (IUBMB) for VILL Gene

Gene Ontology (GO) - Molecular Function for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005200 structural constituent of cytoskeleton TAS 9179494
genes like me logo Genes that share ontologies with VILL: view

Animal Model Products

CRISPR Products

miRNA for VILL Gene

miRTarBase miRNAs that target VILL

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VILL Gene

Localization for VILL Gene

Subcellular locations from

Jensen Localization Image for VILL Gene COMPARTMENTS Subcellular localization image for VILL gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton TAS 9179494
genes like me logo Genes that share ontologies with VILL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for VILL Gene

Pathways for VILL Gene

SuperPathways for VILL Gene

No Data Available

Interacting Proteins for VILL Gene

Gene Ontology (GO) - Biological Process for VILL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0051693 actin filament capping IEA --
genes like me logo Genes that share ontologies with VILL: view

No data available for Pathways by source for VILL Gene

Transcripts for VILL Gene

Unigene Clusters for VILL Gene

Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VILL

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for VILL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VILL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP3: -
SP6: -

Relevant External Links for VILL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VILL Gene

mRNA expression in normal human tissues for VILL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VILL Gene

This gene is overexpressed in Colon - Transverse (6.1) and Stomach (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VILL Gene

SOURCE GeneReport for Unigene cluster for VILL Gene Hs.103665

mRNA Expression by UniProt/SwissProt for VILL Gene

Tissue specificity: Ubiquitously expressed in 16 tissues examined
genes like me logo Genes that share expressions with VILL: view

In Situ Assay Products

Orthologs for VILL Gene

This gene was present in the common ancestor of animals.

Orthologs for VILL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VILL 35
  • 93.41 (n)
  • 90.76 (a)
  • 99 (a)
(Bos Taurus)
Mammalia VILL 35
  • 83.31 (n)
  • 75.09 (a)
  • 72 (a)
(Canis familiaris)
Mammalia VILL 35
  • 80.7 (n)
  • 72.74 (a)
  • 71 (a)
(Mus musculus)
Mammalia Vill 35
  • 79.94 (n)
  • 72.25 (a)
Vill 16
Vill 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia VILL 36
  • 35 (a)
(Rattus norvegicus)
Mammalia Vill 35
  • 80.66 (n)
  • 73.74 (a)
(Gallus gallus)
Aves VILL 35
  • 64.67 (n)
  • 59.16 (a)
(Danio rerio)
Actinopterygii si:dkeyp-57f11.2 36
  • 11 (a)
fruit fly
(Drosophila melanogaster)
Insecta qua 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea gsnl-1 36
  • 32 (a)
Species with no ortholog for VILL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for VILL Gene

Gene Tree for VILL (if available)
Gene Tree for VILL (if available)

Paralogs for VILL Gene

Paralogs for VILL Gene

Selected SIMAP similar genes for VILL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with VILL: view

Variants for VILL Gene

Sequence variations from dbSNP and Humsavar for VILL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs928807 -- 38,000,691(+) GGTAA(G/T)TGCCA intron-variant
rs928808 -- 38,000,968(+) TCTGC(A/C)CCCCA intron-variant
rs1573290 -- 38,006,788(+) GCAGG(G/T)GCAAC intron-variant
rs1892814 - 38,004,279(+) AGCTT(C/G)CAGCC reference, missense, nc-transcript-variant
rs1962765 -- 38,002,964(+) TGCGG(A/G)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VILL Gene

Variant ID Type Subtype PubMed ID
dgv1447e1 CNV Complex 17122850
dgv1448e1 CNV Complex 17122850
nsv428416 CNV Loss 18775914
nsv522354 CNV Loss 19592680

Relevant External Links for VILL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VILL Gene

Disorders for VILL Gene

No disorders were found for VILL Gene.

No data available for UniProtKB/Swiss-Prot for VILL Gene

Publications for VILL Gene

  1. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PMID: 9179494) Ishikawa S. … Nakamura Y. (DNA Res. 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration. (PMID: 16921170) Tomar A. … Khurana S. (J. Biol. Chem. 2006) 3
  4. Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. (PMID: 18006815) Yamamichi N. … Iba H. (Cancer Res. 2007) 3
  5. Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants. (PMID: 18022635) Piana S. … Martins J.C. (J. Mol. Biol. 2008) 3

Products for VILL Gene

Sources for VILL Gene

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