External Ids for VIL1 Gene
Previous HGNC Symbols for VIL1 Gene
Previous GeneCards Identifiers for VIL1 Gene
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]
GeneCards Summary for VIL1 Gene
VIL1 (Villin 1) is a Protein Coding gene. Diseases associated with VIL1 include Microvillus Inclusion Disease and Large Cell Neuroendocrine Carcinoma. Among its related pathways are Cytoskeletal Signaling and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is AVIL.
UniProtKB/Swiss-Prot for VIL1 Gene
Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.