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Aliases for VGLL4 Gene

Aliases for VGLL4 Gene

  • Vestigial Like Family Member 4 2 3 5
  • Vestigial-Like Family Member 4 2 3
  • VGL-4 3 4
  • Vestigial Like 4 (Drosophila) 2
  • Vestigial-Like 4 3
  • Vestigial Like 4 3
  • KIAA0121 4

External Ids for VGLL4 Gene

Previous GeneCards Identifiers for VGLL4 Gene

  • GC03M011573
  • GC03M011574
  • GC03M011597
  • GC03M011558
  • GC03M011559

Summaries for VGLL4 Gene

GeneCards Summary for VGLL4 Gene

VGLL4 (Vestigial Like Family Member 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for VGLL4 Gene

  • May act as a specific coactivator for the mammalian TEFs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGLL4 Gene

Genomics for VGLL4 Gene

Regulatory Elements for VGLL4 Gene

Enhancers for VGLL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VGLL4 on UCSC Golden Path with GeneCards custom track

Promoters for VGLL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VGLL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for VGLL4 Gene

Chromosome:
3
Start:
11,556,067 bp from pter
End:
11,771,350 bp from pter
Size:
215,284 bases
Orientation:
Minus strand

Genomic View for VGLL4 Gene

Genes around VGLL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGLL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGLL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGLL4 Gene

Proteins for VGLL4 Gene

  • Protein details for VGLL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14135-VGLL4_HUMAN
    Recommended name:
    Transcription cofactor vestigial-like protein 4
    Protein Accession:
    Q14135
    Secondary Accessions:
    • B4DTS7
    • J3KN68
    • Q7L5V0
    • Q9BQ78

    Protein attributes for VGLL4 Gene

    Size:
    290 amino acids
    Molecular mass:
    30948 Da
    Quaternary structure:
    • Interacts with TEFs (By similarity). Interacts with IRF2BP2.
    SequenceCaution:
    • Sequence=AAH03038.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAA09470.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for VGLL4 Gene

neXtProt entry for VGLL4 Gene

Proteomics data for VGLL4 Gene at MOPED

Post-translational modifications for VGLL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VGLL4 Gene

Domains & Families for VGLL4 Gene

Gene Families for VGLL4 Gene

Protein Domains for VGLL4 Gene

Suggested Antigen Peptide Sequences for VGLL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q14135

UniProtKB/Swiss-Prot:

VGLL4_HUMAN :
  • Belongs to the vestigial family.
Family:
  • Belongs to the vestigial family.
genes like me logo Genes that share domains with VGLL4: view

Function for VGLL4 Gene

Molecular function for VGLL4 Gene

UniProtKB/Swiss-Prot Function:
May act as a specific coactivator for the mammalian TEFs.

Phenotypes for VGLL4 Gene

genes like me logo Genes that share phenotypes with VGLL4: view

Animal Model Products

miRNA for VGLL4 Gene

miRTarBase miRNAs that target VGLL4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VGLL4 Gene

Localization for VGLL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGLL4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VGLL4 Gene COMPARTMENTS Subcellular localization image for VGLL4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for VGLL4 Gene

Pathways & Interactions for VGLL4 Gene

SuperPathways for VGLL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VGLL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for VGLL4 Gene

Drugs & Compounds for VGLL4 Gene

No Compound Related Data Available

Transcripts for VGLL4 Gene

Unigene Clusters for VGLL4 Gene

Vestigial like 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VGLL4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12:
SP13: - - - - - -
SP14:

ExUns: 18d ^ 19a · 19b · 19c · 19d · 19e
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: -

Relevant External Links for VGLL4 Gene

GeneLoc Exon Structure for
VGLL4
ECgene alternative splicing isoforms for
VGLL4

Expression for VGLL4 Gene

mRNA expression in normal human tissues for VGLL4 Gene

Protein differential expression in normal tissues from HIPED for VGLL4 Gene

This gene is overexpressed in Ovary (39.2), Islet of Langerhans (21.4), and Fetal ovary (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VGLL4 Gene



SOURCE GeneReport for Unigene cluster for VGLL4 Gene Hs.740389

genes like me logo Genes that share expression patterns with VGLL4: view

Protein tissue co-expression partners for VGLL4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VGLL4 Gene

Orthologs for VGLL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VGLL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VGLL4 35
  • 88.3 (n)
  • 91.49 (a)
VGLL4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VGLL4 35
  • 90.88 (n)
  • 92.28 (a)
VGLL4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vgll4 35
  • 86.96 (n)
  • 91.3 (a)
Vgll4 16
Vgll4 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vgll4 35
  • 86.23 (n)
  • 90.58 (a)
oppossum
(Monodelphis domestica)
Mammalia VGLL4 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VGLL4 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VGLL4 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves VGLL4 35
  • 78.09 (n)
  • 81.63 (a)
VGLL4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VGLL4 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vgll4 35
  • 75 (n)
  • 77.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15409 35
zebrafish
(Danio rerio)
Actinopterygii vgll4b 35
  • 76.54 (n)
  • 74.44 (a)
vgll4b 36
  • 72 (a)
OneToOne
Species with no ortholog for VGLL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VGLL4 Gene

ENSEMBL:
Gene Tree for VGLL4 (if available)
TreeFam:
Gene Tree for VGLL4 (if available)

Paralogs for VGLL4 Gene

No data available for Paralogs for VGLL4 Gene

Variants for VGLL4 Gene

Sequence variations from dbSNP and Humsavar for VGLL4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2276749 - 11,601,991(+) GTCTG(A/C/T)ATTCT reference, missense, utr-variant-5-prime
rs1039199 -- 11,673,254(-) tatat(A/G)tatat intron-variant
rs1039200 -- 11,689,372(+) TTGCT(A/C)TCTAT intron-variant
rs1039201 -- 11,689,555(+) GATAC(C/T)GACTA intron-variant
rs1039202 -- 11,689,585(+) TATGC(G/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VGLL4 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
dgv5107n71 CNV Loss 21882294
esv2677845 CNV Deletion 23128226
nsv517831 CNV Loss 19592680
nsv821986 CNV Loss 20364138
nsv520880 CNV Loss 19592680
esv2724912 CNV Deletion 23290073
esv2283589 CNV Deletion 18987734
esv4895 CNV Deletion 18987735
nsv237362 CNV Loss 16902084
esv1423720 CNV Deletion 17803354
esv2512352 CNV Insertion 19546169
nsv511196 CNV Loss 21212237
nsv513035 CNV Loss 21212237
dgv791n67 CNV Loss 20364138
esv2724913 CNV Deletion 23290073
esv26292 CNV Loss 19812545
esv2724914 CNV Deletion 23290073
esv2724915 CNV Deletion 23290073
esv2130512 CNV Deletion 18987734
esv2661608 CNV Deletion 23128226
esv270454 CNV Insertion 20981092
esv272805 CNV Insertion 20981092
nsv821990 CNV Loss 20364138
esv25016 CNV Loss 19812545

Variation tolerance for VGLL4 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VGLL4 Gene

Disorders for VGLL4 Gene

Relevant External Links for VGLL4

Genetic Association Database (GAD)
VGLL4
Human Genome Epidemiology (HuGE) Navigator
VGLL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VGLL4

No disorders were found for VGLL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VGLL4 Gene

Publications for VGLL4 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 67
  2. Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes. (PMID: 15140898) Chen H.H. … Stewart A.F. (J. Biol. Chem. 2004) 2 3 23
  3. Downregulation of VGLL4 in the progression of esophageal squamous cell carcinoma. (PMID: 25352025) Jiang W. … He J. (Tumour Biol. 2015) 3
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  5. VGLL4 inhibits EMT in part through suppressing Wnt/I^-catenin signaling pathway in gastric cancer. (PMID: 25701461) Li H. … Zhang S. (Med. Oncol. 2015) 3

Products for VGLL4 Gene

Sources for VGLL4 Gene

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