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Aliases & Descriptions for VGLL4
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KIAA0121 1 , 2 , 3 VGL-4 2 Vgl-4 3
Descriptions Vestigial-like 4 2 vestigial like 4 2 vestigial like 4 (Drosophila) 2
Search outside databases for aliases for VGLL4 genePrevious GC identifer: GC03M011573
Summaries for VGLL4 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: VGLL4_HUMAN, Q14135 Function : May act as a specific coactivator for the mammalian TEFs (By similarity)
Genomic Location for VGLL4
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the VGLL4 gene Entrez Gene cytogenetic band: 3p25.2 Ensembl cytogenetic band: 3p25.2 HGNC cytogenetic band: 3p25.2 VGLL4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M011574:
(about GC identifiers )
Start:
11,572,544 bp from pter
End:
11,737,205 bp from pter
Size:
164,662 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000003.10 NT_022517.17 Proteins for VGLL4
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: VGLL4_HUMAN, Q14135 (See
protein sequence )Recommended Name: Transcription cofactor vestigial-like protein 4 Size : 290 amino acids; 30948 Da
Subunit : Interacts with TEFs (By similarity)
Subcellular location : Nucleus (By similarity)
Secondary accessions : B4DTS7 Q7L5V0 Q9BQ78Alternative splicing : 2 isoforms : Q14135-1 Q14135-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (4 alternative transcripts):
NP_001121691.1 NP_001121692.1 NP_001121693.1 NP_055482.2 ENSEMBL proteins: ENSP00000384705 ENSP00000273038 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: VGLL4 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About this table Antibodies for VGLL4: Assays for VGLL4:
Protein
Domains/ Families for VGLL4(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q14135 ProtoNet protein and cluster: Q14135
1 Blocks protein family : IPB006627 Protein of unknown function TDU UniProtKB/Swiss-Prot: VGLL4_HUMAN, Q14135 Similarity : Belongs to the vestigial family
Gene Function for VGLL4
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): XM_052386 Applied Biosystems Silencer ® siRNAs for VGLL4 Sigma-Aldrich siRNA for VGLL4 Sigma-Aldrich shRNA for VGLL4 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001128219                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001128219                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_001128219  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001128219 UniProtKB/Swiss-Prot: VGLL4_HUMAN, Q14135 Function : May act as a specific coactivator for the mammalian TEFs (By similarity)
Pathways & Interactions for VGLL4
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for VGLL4 2 Interacting proteins for VGLL4 (ENSP00000273038 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA --
About this table
Drugs & Compounds for VGLL4 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for VGLL4
Transcripts for VGLL4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): XM_052386 Sigma-Aldrich siRNA for VGLL4 Sigma-Aldrich shRNA for VGLL4 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001128219 NM_001128220 NM_001128221 NM_014667
REFSEQ mRNAs for VGLL4 gene (4 alternative transcripts): NM_001128219.1 NM_001128220.1 NM_001128221.1 NM_014667.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001128219 NM_001128220 NM_001128221 NM_014667
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001128219                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001128219                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_001128219  
Additional cDNA sequence: AK126479.1 AK130542.1 AK300344.1 AK307708.1 AK308761.1 BC000763.2 BC001514.2 BC003038.1 CR602971.1 CR614960.1 D50911.3
24/25 DOTS entries (see all 25
): DT.95155732 DT.40286625 DT.95155731 DT.92448622 DT.40116097 DT.119954 DT.100823023 DT.92448576 DT.120922148 DT.97805866 DT.100823026 DT.92448572 DT.100823033 DT.92448616 DT.95155734 DT.91998774 DT.100739897 DT.95107467 DT.100014647 DT.100038018 DT.100701137 DT.100727123 DT.120922072 DT.92448573
24/438 AceView cDNA sequences (see all 438
):BQ446105 AW103730 AW276579 AI620922 R02766 AA447150 BU683012 BF929304 BF001351 AW161712 CB321734 T33688 AI148948 AA994627 AW161703 AA258583 CB146197 AI419609 AI192831 AI360497 AA490577 AW054645 AW161031 BM832856
highest scoring ESTs for VGLL4 :D50911 AA042933 AA287241 AA465646 AI816218 AK130542 AL560729 AW245806 AW500228 BC000763
Unigene Cluster for VGLL4: Vestigial like 4 (Drosophila) Hs.38032 [show with all ESTs ] Unigene Representative Sequence: AK126479 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for VGLL4 (see all 14
) ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c · SP1 :     -   -   -       -   -   -   -   -   -     -   -   -   -       -   -   -         SP2 :     -   -   -     -   -   -   -   -   -   -     -   -   -   -       -   -   -         SP3 :   -   -   -   -     -   -   -   -   -   -   -     -   -   -   -       -   -   -         SP4 :             -   -   -   -   -   -   -     -   -   -   -       -   -   -         SP5 :                     -   -   -     -   -   -   -       -   -   -        
ExUns: 18d ^ 19a · 19b · 19c · 19d · 19e SP1 :   -           SP2 :   -           SP3 :             SP4 :             SP5 :   -          
About this scheme ECgene alternative splicing isoforms for VGLL4 2 Ensembl transcripts including schematic representations : ENST00000404339
ENST00000273038
Expression for VGLL4
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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VGLL4 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for VGLL4 1 / 2 / 3
5 probe-sets matching VGLL4 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGTGTAAATCSOURCE GeneReport for Unigene cluster: Hs.38032 Expression variation in blood from EXPOLDB for VGLL4
Orthologs for VGLL4
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for VGLL4 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for VGLL4 ENSEMBL Gene Tree for VGLL4 Paralogs for VGLL4 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for VGLL4 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for VGLL4 (up to first 250kb)
Disorders & Mutations for VGLL4
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Human Genome Epidemiology Navigator: VGLL4 (1 document)
Medical News for VGLL4 (Possibly Related Articles in
Doctor's Guide )
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Publications for VGLL4 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for VGLL4 gene : Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280) 2, 3, 4 Nagase T....Nomura N. (1995) Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes. (PubMed id 15140898) 1, 2, 3 Chen H.H....Stewart A.F. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 3 Trynka G....Wijmenga C. (2009) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 4 Cantin G.T....Yates J.R. III (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing VGLL4
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing VGLL4
(According to HUGE )
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Specialized Databases showing VGLL4 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for VGLL4 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for VGLL4:
Recombinant Proteins (Vgl4 ) Antibodies (Vgl4 )
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