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VGLL4 Gene

protein-coding   GIFtS: 56

GC03M011574
vestigial like 4 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
KIAA0121 1, 2, 3
VGL-4 2
Vgl-4 3
Descriptions
Vestigial-like 4 2
vestigial like 4 2
vestigial like 4 (Drosophila) 2
External Ids
HGNC: 289661
Entrez Gene: 96862
UniProtKB: Q141353
Ensembl: ENSG000001445607
Search outside databases for aliases for VGLL4 gene

Previous GC identifer: GC03M011573

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VGLL4_HUMAN, Q14135
Function: May act as a specific coactivator for the mammalian TEFs (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VGLL4 gene  

Entrez Gene cytogenetic band: 3p25.2   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

VGLL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M011574:     (about GC identifiers)

Start:
11,572,544 bp from pter
End:
11,737,205 bp from pter
Size:
164,662 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_022517.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VGLL4_HUMAN, Q14135 (See protein sequence)
Recommended Name: Transcription cofactor vestigial-like protein 4  
Size: 290 amino acids; 30948 Da
Subunit: Interacts with TEFs (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: B4DTS7 Q7L5V0 Q9BQ78
Alternative splicing: 2 isoforms:  Q14135-1   Q14135-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001121691.1  NP_001121692.1  NP_001121693.1  NP_055482.2  


    ENSEMBL proteins: 
    ENSP00000384705 ENSP00000273038 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Vgl4)
    Human Recombinant Proteins from Abnova (VGLL4)
                  OriGene Purified Recombinant Human Protein: VGLL4 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for VGLL4: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for VGLL4
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Vgl4), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (VGLL4)
    Novus Biologicals Antibody for VGLL4

    Assays for VGLL4: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR006627 DUF_TDU


       GeneDecks  VGLL4 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q14135

    ProtoNet protein and cluster: Q14135

    1 Blocks protein family: IPB006627 Protein of unknown function TDU

    UniProtKB/Swiss-Prot: VGLL4_HUMAN, Q14135
    Similarity: Belongs to the vestigial family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VGLL4)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_052386

                  Applied Biosystems Silencer® siRNAs for VGLL4

                  Sigma-Aldrich siRNA for VGLL4  
                         Sigma-Aldrich shRNA for VGLL4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for VGLL4
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001128219
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001128219
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_001128219 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001128219

    UniProtKB/Swiss-Prot: VGLL4_HUMAN, Q14135
    Function: May act as a specific coactivator for the mammalian TEFs (By similarity)

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  VGLL4 


    2 Interacting proteins for VGLL4 (ENSP000002730383) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEAD1ENSP000003347543STRING (score=.964)
    VGLL2ENSP000003209573STRING (score=.716)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for VGLL4

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VGLL4)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_052386

                  Sigma-Aldrich siRNA for VGLL4  
                         Sigma-Aldrich shRNA for VGLL4  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001128219  NM_001128220  NM_001128221  NM_014667  

    REFSEQ mRNAs for VGLL4 gene (4 alternative transcripts): 

    NM_001128219.1   NM_001128220.1   NM_001128221.1   NM_014667.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001128219  NM_001128220  NM_001128221  NM_014667  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001128219
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001128219
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_001128219 

    Additional cDNA sequence: 

    AK126479.1 AK130542.1 AK300344.1 AK307708.1 AK308761.1 BC000763.2 BC001514.2 BC003038.1 
    CR602971.1 CR614960.1 D50911.3 

    24/25 DOTS entries (see all 25 ):

    DT.95155732  DT.40286625  DT.95155731  DT.92448622  DT.40116097  DT.119954  DT.100823023  DT.92448576 
    DT.120922148  DT.97805866  DT.100823026  DT.92448572  DT.100823033  DT.92448616  DT.95155734  DT.91998774 
    DT.100739897  DT.95107467  DT.100014647  DT.100038018  DT.100701137  DT.100727123  DT.120922072  DT.92448573 

    24/438 AceView cDNA sequences (see all 438 ):

    BQ446105 AW103730 AW276579 AI620922 R02766 AA447150 BU683012 BF929304 
    BF001351 AW161712 CB321734 T33688 AI148948 AA994627 AW161703 AA258583 
    CB146197 AI419609 AI192831 AI360497 AA490577 AW054645 AW161031 BM832856 

    highest scoring ESTs for VGLL4:

    D50911 AA042933 AA287241 AA465646 AI816218 AK130542 AL560729 AW245806 AW500228 BC000763 

    Unigene Cluster for VGLL4:

    Vestigial like 4 (Drosophila)
    Hs.38032  [show with all ESTs]
    Unigene Representative Sequence: AK126479


    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for VGLL4 (see all 14 )

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ·
    SP1:              -     -     -                 -     -     -     -     -     -           -     -     -     -                 -     -     -                     
    SP2:              -     -     -           -     -     -     -     -     -     -           -     -     -     -                 -     -     -                     
    SP3:        -     -     -     -           -     -     -     -     -     -     -           -     -     -     -                 -     -     -                     
    SP4:                                      -     -     -     -     -     -     -           -     -     -     -                 -     -     -                     
    SP5:                                                              -     -     -           -     -     -     -                 -     -     -                     

    ExUns: 18d ^ 19a · 19b · 19c · 19d · 19e
    SP1:        -                           
    SP2:        -                           
    SP3:                                    
    SP4:                                    
    SP5:        -                           

    About this scheme

    ECgene alternative splicing isoforms for VGLL4

    2 Ensembl transcripts including schematic representations:
    ENST00000404339  ENST00000273038  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    VGLL4 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for VGLL4

    1 / 2 / 3

    5 probe-sets matching VGLL4 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    40279_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D50911 1.00 1.00 1.00 1

    212399_s_at2, 3 U133-A 1 1.00 1.00 -- -- D50911 1.00 1.00 1.00 1

    214004_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI806207 0.40 1.00 0.76 1

    212399_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    214004_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGTGTAAATC

    SOURCE GeneReport for Unigene cluster: Hs.38032

    Expression variation in blood from EXPOLDB for VGLL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for VGLL4 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    VGLL41   -- vestigial like 4 (Drosophila) 90.55(n)
    92.16(a)
    607588  XM_844730.1  XP_849823.1 
    cow
    (Bos taurus)
    VGLL41   -- vestigial like 4 (Drosophila) 87.55(n)
    91.32(a)
    613904  XM_865109.2  XP_870202.2 
    rat
    (Rattus norvegicus)
    Vgll41   -- vestigial like 4 (Drosophila) 85.97(n)
    90.73(a)
    297523  NM_001015004.1  NP_001015004.1 
    mouse
    (Mus musculus)
    Vgll41, 5 65
    vestigial like 4 (Drosophila)1, 5 86.87(n)1
    91.51(a)1
    2323341  NM_177683.21  NP_808351.11 
     AI4523445  AK0784665  (see all 14)
    chicken
    (Gallus gallus)
    VGLL41   -- vestigial like 4 (Drosophila) 76.57(n)
    80.08(a)
    415962  NM_001030593.1  NP_001025764.1 
    About this table        Species with no ortholog for VGLL4

    ENSEMBL Gene Tree for VGLL4
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1249 NCBI SNPs in VGLL4 are shown (see all 1249 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 357)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs98559861,2
    A,C,F,H11572277(+) GTAGAG/AGGCAT 1 -- ng514Minor allele frequency- A:0.04EU EA WA 420
    rs111285701,2
    A,C,F,H11738001(+) AAAGCT/CCGGAA 1 -- ng316Minor allele frequency- C:0.40EU EA WA NA 602
    rs98811511,2
    C,F,H11573378(+) CCACTT/CTTCAA 4 -- ut31 ese37Minor allele frequency- C:0.01EU EA WA NA 558
    rs22767491,2
    C,F,H11618465(+) GTCTGC/TATTCT 2 I/M mis1 ese310Minor allele frequency- T:0.08EA EU WA NA 1648
    rs46847891,2
    A,C11572087(+) GAGCAG/TGCCAG 1 -- ng510--------
    --
    rs73558281,2
    C11574733(+) GCCCCA/GTCGGG 4 -- ut31 ese30--------
    rs10569941,2
    H11574336(-) GATTTC/TAGGTG 4 -- ut31 ese35Minor allele frequency- T:0.00MN EU EA WA 602
    --
    rs163401,2
    F11573813(+) TTGTCTGTC/-  
            
    AGTAA
    4 -- ut314Minor allele frequency- -:0.16EU NA EA 342
    rs37326901,2
    F11738570(+) TGCTGC/ATAAAT 1 -- ng311Minor allele frequency- A:0.01EA 1478
    rs37326891,2
    H11738414(+) TTATGA/TACAGA 1 -- ng314Minor allele frequency- T:0.00EU EA WA 406
    About this table

    HapMap Linkage Disequilibrium images for VGLL4 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    Human Genome Epidemiology Navigator: VGLL4 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for VGLL4 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9686 HGNC: 28966 AceView: VGLL4 Ensembl:ENSG00000144560 euGenes: HUgn9686
    ECgene: VGLL4 H-InvDB: VGLL4
    (According to HUGE)
    About This Section

    HUGE: KIAA0121
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for VGLL4:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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