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Aliases for VGLL3 Gene

Aliases for VGLL3 Gene

  • Vestigial Like Family Member 3 2 3 5
  • VGL-3 3 4
  • Colon Carcinoma Related Protein 3
  • Vestigial-Like Family Member 3 2
  • Vestigial Like 3 (Drosophila) 2
  • VGL3 3

External Ids for VGLL3 Gene

Previous GeneCards Identifiers for VGLL3 Gene

  • GC03M087071

Summaries for VGLL3 Gene

GeneCards Summary for VGLL3 Gene

VGLL3 (Vestigial Like Family Member 3) is a Protein Coding gene. An important paralog of this gene is VGLL2.

UniProtKB/Swiss-Prot for VGLL3 Gene

  • May act as a specific coactivator for the mammalian TEFs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGLL3 Gene

Genomics for VGLL3 Gene

Regulatory Elements for VGLL3 Gene

Enhancers for VGLL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around VGLL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for VGLL3 Gene

Chromosome:
3
Start:
86,937,969 bp from pter
End:
86,991,287 bp from pter
Size:
53,319 bases
Orientation:
Minus strand

Genomic View for VGLL3 Gene

Genes around VGLL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGLL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGLL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGLL3 Gene

Proteins for VGLL3 Gene

  • Protein details for VGLL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MV65-VGLL3_HUMAN
    Recommended name:
    Transcription cofactor vestigial-like protein 3
    Protein Accession:
    A8MV65
    Secondary Accessions:
    • D3DU37
    • Q504T7

    Protein attributes for VGLL3 Gene

    Size:
    326 amino acids
    Molecular mass:
    36009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VGLL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VGLL3 Gene

Proteomics data for VGLL3 Gene at MOPED

Post-translational modifications for VGLL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VGLL3 Gene

No data available for DME Specific Peptides for VGLL3 Gene

Domains & Families for VGLL3 Gene

Gene Families for VGLL3 Gene

Protein Domains for VGLL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VGLL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MV65

UniProtKB/Swiss-Prot:

VGLL3_HUMAN :
  • Belongs to the vestigial family.
Family:
  • Belongs to the vestigial family.
genes like me logo Genes that share domains with VGLL3: view

Function for VGLL3 Gene

Molecular function for VGLL3 Gene

UniProtKB/Swiss-Prot Function:
May act as a specific coactivator for the mammalian TEFs.
genes like me logo Genes that share phenotypes with VGLL3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VGLL3 Gene

Localization for VGLL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGLL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VGLL3 Gene COMPARTMENTS Subcellular localization image for VGLL3 gene
Compartment Confidence
nucleus 5
cytosol 3
endosome 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for VGLL3 Gene

Pathways & Interactions for VGLL3 Gene

SuperPathways for VGLL3 Gene

No Data Available

Interacting Proteins for VGLL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381436%0d%0a9606.ENSP00000356234%0d%0a
Selected Interacting proteins: ENSP00000381436 A8MV65-VGLL3_HUMAN for VGLL3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for VGLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with VGLL3: view

No data available for Pathways by source and SIGNOR curated interactions for VGLL3 Gene

Drugs & Compounds for VGLL3 Gene

No Compound Related Data Available

Transcripts for VGLL3 Gene

Unigene Clusters for VGLL3 Gene

Vestigial like 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VGLL3 Gene

No ASD Table

Relevant External Links for VGLL3 Gene

GeneLoc Exon Structure for
VGLL3
ECgene alternative splicing isoforms for
VGLL3

Expression for VGLL3 Gene

mRNA expression in normal human tissues for VGLL3 Gene

Protein differential expression in normal tissues from HIPED for VGLL3 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VGLL3 Gene



SOURCE GeneReport for Unigene cluster for VGLL3 Gene Hs.744116

mRNA Expression by UniProt/SwissProt for VGLL3 Gene

A8MV65-VGLL3_HUMAN
Tissue specificity: Enriched in placenta.
genes like me logo Genes that share expression patterns with VGLL3: view

Protein tissue co-expression partners for VGLL3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for VGLL3 Gene

Orthologs for VGLL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for VGLL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VGLL3 35
  • 89.54 (n)
  • 88.62 (a)
VGLL3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VGLL3 35
  • 92.4 (n)
  • 91.58 (a)
VGLL3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vgll3 35
  • 89.44 (n)
  • 89.13 (a)
Vgll3 16
Vgll3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VGLL3 35
  • 99.39 (n)
  • 99.69 (a)
VGLL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vgll3 35
  • 90.53 (n)
  • 89.2 (a)
oppossum
(Monodelphis domestica)
Mammalia VGLL3 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VGLL3 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves VGLL3 35
  • 76.87 (n)
  • 73.47 (a)
VGLL3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VGLL3 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vgll3 35
  • 67.53 (n)
  • 66.95 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331764 35
  • 50.76 (n)
  • 43.56 (a)
VGLL3 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vg 36
  • 14 (a)
OneToMany
Species with no ortholog for VGLL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VGLL3 Gene

ENSEMBL:
Gene Tree for VGLL3 (if available)
TreeFam:
Gene Tree for VGLL3 (if available)

Paralogs for VGLL3 Gene

Paralogs for VGLL3 Gene

genes like me logo Genes that share paralogs with VGLL3: view

Variants for VGLL3 Gene

Sequence variations from dbSNP and Humsavar for VGLL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13356 -- 86,940,929(-) ACAAG(A/C)AGTTG utr-variant-3-prime
rs1025631 -- 86,972,224(-) TTTCA(A/G)TAATA intron-variant
rs1046713 -- 86,941,442(-) ATTTC(C/T)AGACT utr-variant-3-prime
rs1046715 -- 86,941,181(-) TCAGG(A/G)GATAA utr-variant-3-prime
rs1898266 -- 86,973,843(-) AGTTG(C/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VGLL3 Gene

Variant ID Type Subtype PubMed ID
nsv519148 CNV Gain 19592680
nsv527279 CNV Gain 19592680

Variation tolerance for VGLL3 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for VGLL3 Gene

Disorders for VGLL3 Gene

Relevant External Links for VGLL3

Genetic Association Database (GAD)
VGLL3
Human Genome Epidemiology (HuGE) Navigator
VGLL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VGLL3

No disorders were found for VGLL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VGLL3 Gene

Publications for VGLL3 Gene

  1. Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. (PMID: 12376544) Maeda T. … Stewart A.F.R. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Vestigial-like 3 is an inhibitor of adipocyte differentiation. (PMID: 23152581) Halperin D.S. … Tontonoz P. (J. Lipid Res. 2013) 3
  3. VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer. (PMID: 23415753) Gambaro K. … Tonin P.N. (Mol Oncol 2013) 3
  4. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PMID: 23449627) Cousminer D.L. … WidAcn E. (Hum. Mol. Genet. 2013) 3
  5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3

Products for VGLL3 Gene

Sources for VGLL3 Gene

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