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Aliases for VGLL3 Gene

Aliases for VGLL3 Gene

  • Vestigial-Like Family Member 3 2 3
  • VGL-3 3 4
  • VGL3 3 6
  • Transcription Cofactor Vestigial-Like Protein 3 3
  • Colon Carcinoma Related Protein 3
  • Vestigial Like 3 (Drosophila) 2
  • Vestigial Like 3 3
  • Vestigial-Like 3 3

External Ids for VGLL3 Gene

Previous GeneCards Identifiers for VGLL3 Gene

  • GC03M087071

Summaries for VGLL3 Gene

GeneCards Summary for VGLL3 Gene

VGLL3 (Vestigial-Like Family Member 3) is a Protein Coding gene. An important paralog of this gene is VGLL2.

UniProtKB/Swiss-Prot for VGLL3 Gene

  • May act as a specific coactivator for the mammalian TEFs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGLL3 Gene

Genomics for VGLL3 Gene

Regulatory Elements for VGLL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VGLL3 Gene

Start:
86,937,969 bp from pter
End:
86,991,260 bp from pter
Size:
53,292 bases
Orientation:
Minus strand

Genomic View for VGLL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VGLL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGLL3 Gene

Proteins for VGLL3 Gene

  • Protein details for VGLL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MV65-VGLL3_HUMAN
    Recommended name:
    Transcription cofactor vestigial-like protein 3
    Protein Accession:
    A8MV65
    Secondary Accessions:
    • D3DU37
    • Q504T7

    Protein attributes for VGLL3 Gene

    Size:
    326 amino acids
    Molecular mass:
    36009 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for VGLL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VGLL3 Gene

Proteomics data for VGLL3 Gene at MOPED

Post-translational modifications for VGLL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VGLL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VGLL3 Gene

Domains for VGLL3 Gene

Protein Domains for VGLL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VGLL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MV65

UniProtKB/Swiss-Prot:

VGLL3_HUMAN :
  • A8MV65
Family:
  • Belongs to the vestigial family.
genes like me logo Genes that share domains with VGLL3: view

No data available for Gene Families for VGLL3 Gene

Function for VGLL3 Gene

Molecular function for VGLL3 Gene

UniProtKB/Swiss-Prot Function: May act as a specific coactivator for the mammalian TEFs.

Animal Model Products

CRISPR Products

miRNA for VGLL3 Gene

miRTarBase miRNAs that target VGLL3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VGLL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for VGLL3 Gene

Localization for VGLL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGLL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VGLL3 Gene COMPARTMENTS Subcellular localization image for VGLL3 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for VGLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with VGLL3: view

Pathways for VGLL3 Gene

SuperPathways for VGLL3 Gene

No Data Available

Interacting Proteins for VGLL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381436%0d%0a9606.ENSP00000356234%0d%0a
Selected Interacting proteins: ENSP00000381436 A8MV65-VGLL3_HUMAN for VGLL3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for VGLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with VGLL3: view

No data available for Pathways by source for VGLL3 Gene

Transcripts for VGLL3 Gene

Unigene Clusters for VGLL3 Gene

Vestigial like 3 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VGLL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VGLL3 Gene

No ASD Table

Relevant External Links for VGLL3 Gene

GeneLoc Exon Structure for
VGLL3
ECgene alternative splicing isoforms for
VGLL3

Expression for VGLL3 Gene

mRNA expression in normal human tissues for VGLL3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VGLL3 Gene

SOURCE GeneReport for Unigene cluster for VGLL3 Gene Hs.744116

mRNA Expression by UniProt/SwissProt for VGLL3 Gene

A8MV65-VGLL3_HUMAN
Tissue specificity: Enriched in placenta.
genes like me logo Genes that share expressions with VGLL3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for VGLL3 Gene

Orthologs for VGLL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for VGLL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VGLL3 35
  • 99.39 (n)
  • 99.69 (a)
VGLL3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VGLL3 35
  • 89.54 (n)
  • 88.62 (a)
VGLL3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VGLL3 35
  • 92.4 (n)
  • 91.58 (a)
VGLL3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vgll3 35
  • 89.44 (n)
  • 89.13 (a)
Vgll3 16
Vgll3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VGLL3 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VGLL3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vgll3 35
  • 90.53 (n)
  • 89.2 (a)
chicken
(Gallus gallus)
Aves VGLL3 35
  • 76.87 (n)
  • 73.47 (a)
VGLL3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VGLL3 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vgll3 35
  • 67.53 (n)
  • 66.95 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331764 35
  • 50.76 (n)
  • 43.56 (a)
VGLL3 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vg 36
  • 14 (a)
OneToMany
Species with no ortholog for VGLL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VGLL3 Gene

ENSEMBL:
Gene Tree for VGLL3 (if available)
TreeFam:
Gene Tree for VGLL3 (if available)

Paralogs for VGLL3 Gene

Paralogs for VGLL3 Gene

genes like me logo Genes that share paralogs with VGLL3: view

Variants for VGLL3 Gene

Sequence variations from dbSNP and Humsavar for VGLL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13356 -- 86,940,929(-) ACAAG(A/C)AGTTG utr-variant-3-prime
rs14416 -- 86,938,567(-) TCAGC(A/T)TTGAT utr-variant-3-prime
rs959081 -- 86,972,963(-) TTACT(A/G)GGTTT intron-variant
rs1025631 -- 86,972,224(-) TTTCA(A/G)TAATA intron-variant
rs1046713 -- 86,941,442(-) ATTTC(C/T)AGACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for VGLL3 Gene

Variant ID Type Subtype PubMed ID
nsv519148 CNV Gain 19592680
nsv527279 CNV Gain 19592680

Relevant External Links for VGLL3 Gene

HapMap Linkage Disequilibrium report
VGLL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGLL3 Gene

Disorders for VGLL3 Gene

Relevant External Links for VGLL3

Genetic Association Database (GAD)
VGLL3
Human Genome Epidemiology (HuGE) Navigator
VGLL3
genes like me logo Genes that share disorders with VGLL3: view

No data available for UniProtKB/Swiss-Prot for VGLL3 Gene

Publications for VGLL3 Gene

  1. Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. (PMID: 12376544) Maeda T. … Stewart A.F.R. (J. Biol. Chem. 2002) 2 3 4 23
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 48
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3
  4. Vestigial-like 3 is an inhibitor of adipocyte differentiation. (PMID: 23152581) Halperin D.S. … Tontonoz P. (J. Lipid Res. 2013) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for VGLL3 Gene

Sources for VGLL3 Gene

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