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VGLL2 Gene

protein-coding   GIFtS: 51

GC06P117693
vestigial like 2 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for VGLL2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
OTTHUMP00000017081 2
VGL2 2, 5
VITO1 2, 3, 5
Vgl-2 3
Descriptions
Protein VITO1 3
transcription cofactor vestigial-like 2 2
vestigial like 2 (Drosophila) 2
vestigial-like 2 2
External Ids
HGNC: 202321
Entrez Gene: 2458062
UniProtKB: Q8N8G23
Ensembl: ENSG000001701627
Search outside databases for aliases for VGLL2 gene

Previous GC identifers: GC06P117586 GC06P117632

Summaries
for VGLL2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VGLL2_HUMAN, Q8N8G2
Function: May act as a specific coactivator for the mammalian TEFs. May play a role in the
development of skeletal muscles

Genomic Location
for VGLL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VGLL2 gene  

Entrez Gene cytogenetic band: 6q22.2   Ensembl cytogenetic band:  6q22.2   HGNC cytogenetic band: 6q22.31

VGLL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P117693:     (about GC identifiers)

Start:
 117,693,414 bp from pter
End:
 117,701,421 bp from pter
Size:
 8,008 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  

Proteins
for VGLL2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: VGLL2_HUMAN, Q8N8G2 (See protein sequence)
Recommended Name: Transcription cofactor vestigial-like protein 2  
Size: 317 amino acids; 33426 Da
Subunit: Interacts with TEFs. Binds to TEAD1/TEF1
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q8WWX1
Alternative splicing: 2 isoforms:  Q8N8G2-1   Q8N8G2-2   

REFSEQ proteins (2 alternative transcripts): 
NP_703154.1  NP_872586.1  


ENSEMBL proteins: 
ENSP00000320957 ENSP00000305405 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (VGLL2)
Human Recombinant Proteins from Abnova (VGLL2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
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Antibodies for VGLL2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for VGLL2
Browse R&D Systems for Antibodies
Antibodies from Abcam (VGLL2), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (VGLL2)
Novus Biologicals Antibody for VGLL2

Assays for VGLL2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for VGLL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro domains/families:
 IPR006627 DUF_TDU
 IPR011520 Vg_Tdu


   GeneDecks  VGLL2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8N8G2

ProtoNet protein and cluster: Q8N8G2

1 Blocks protein family: IPB011520 Vestigial/tondu

UniProtKB/Swiss-Prot: VGLL2_HUMAN, Q8N8G2
Similarity: Belongs to the vestigial family

Gene Function
for VGLL2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (VGLL2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (VGLL2)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182645

              Applied Biosystems Silencer® siRNAs for VGLL2

              Sigma-Aldrich siRNA for VGLL2  
                     Sigma-Aldrich shRNA for VGLL2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for VGLL2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_153453
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_153453
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_153453 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_182645

UniProtKB/Swiss-Prot: VGLL2_HUMAN, Q8N8G2
Function: May act as a specific coactivator for the mammalian TEFs. May play a role in the
development of skeletal muscles

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0030528 transcription regulator activity IEA--
About this table

Pathways & Interactions
for VGLL2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  VGLL2 


5 Interacting proteins for VGLL2 (ENSP000003209573) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
TEAD1ENSP000003347543STRING (score=.972)
TEAD4ENSP000003529263STRING (score=.862)
YAP1ENSP000002824413STRING (score=.853)
VGLL4ENSP000002730383STRING (score=.716)
MYOD1ENSP000002500033STRING (score=.705)
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table

Drugs & Compounds
for VGLL2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for VGLL2

Transcripts
for VGLL2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (VGLL2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (VGLL2)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182645

              Sigma-Aldrich siRNA for VGLL2  
                     Sigma-Aldrich shRNA for VGLL2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_153453  NM_182645  

REFSEQ mRNAs for VGLL2 gene (2 alternative transcripts): 

NM_153453.1   NM_182645.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_153453  NM_182645  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_153453
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_153453
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_153453 

Additional cDNA sequence: 

AJ578053.1 AK096878.1 AY056583.1 BC069316.1 BC100798.2 BC100799.1 BC118545.1 BC118622.1 

2 DOTS entries:

DT.453959  DT.101978559 

19 AceView cDNA sequences:

AI004234 BC069316 F37053 AY056583 AJ578053 NM_153453 NM_182645 AI292308 
BX500052 AK096878 AA453413 AI419661 AI039121 F28435 AI077557 AI276196 
AI382386 F32027 AA453919 

highest scoring ESTs for VGLL2:

AI292308 AA453413 AA453919 AI004234 AI077557 AI276196 AI382386 AI419661 AJ578053 AK096878 

Unigene Cluster for VGLL2:

Vestigial like 2 (Drosophila)
Hs.99324  [show with all ESTs]
Unigene Representative Sequence: NM_182645


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for VGLL2

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:                              
SP2:                    -         

About this scheme

ECgene alternative splicing isoforms for VGLL2

2 Ensembl transcripts including schematic representations:
ENST00000326274  ENST00000352536  

Expression
for VGLL2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

VGLL2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for VGLL2

1 / 2 / 3

3 probe-sets matching VGLL2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
56082_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI292308 1.00 1.00 1.00 1

236352_at2, 3 U133-B 1 1.00 1.00 -- -- AI276196 0.80 1.00 0.91 1

236352_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  VGLL2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGGGAAGGCA

SOURCE GeneReport for Unigene cluster: Hs.99324

UniProtKB/Swiss-Prot: VGLL2_HUMAN, Q8N8G2
Tissue specificity: Skeletal muscle

Orthologs
for VGLL2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for VGLL2 gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 VGLL21   -- vestigial like 2 (Drosophila) 92.27(n)
95.75(a)		 484097  XM_541214.2  XP_541214.2 
chimpanzee
(Pan troglodytes)		 VGLL21   -- vestigial like 2 (Drosophila) 99.47(n)
99.05(a)		 743393  XM_001162679.1  XP_001162679.1 
rat
(Rattus norvegicus)		 Vgll21   -- vestigial like 2 (Drosophila) 85.39(n)
87.34(a)		 309772  XM_228170.4  XP_228170.4 
mouse
(Mus musculus)		 Vgll21, 5 105
 vestigial like 2 homolog (Drosophila)1, 5 85.88(n)1
88.6(a)1		 2150311  NM_153786.11  NP_722481.11 
 AF5421815  AJ5780545  (see all 8)
chicken
(Gallus gallus)		 VGLL21   -- vestigial like 2 (Drosophila) 75.28(n)
74.49(a)		 421735  XM_419768.2  XP_419768.2 
About this table        Species with no ortholog for VGLL2

ENSEMBL Gene Tree for VGLL2

Paralogs
for VGLL2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for VGLL2 gene
VGLL12  VGLL32  

SNPs/Variants
for VGLL2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/62 NCBI SNPs in VGLL2 are shown (see all 62 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 62)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs4238681,2
A,C,F,H117692188(+) TTCCGC/TCACCT 2 -- ng51 tfbs38Minor allele frequency- T:0.31EU EA WA NA 774
rs8035961,2
A,C,F,H117692246(-) TCTTCA/CGTTCT 2 -- ng518Minor allele frequency- C:0.14EU EA WA 838
rs4180891,2
A,C,F117692279(+) CAGAGG/AGCTTG 2 -- ng511Minor allele frequency- A:0.41MN 184
rs38229471,2
C,F,H117701338(+) GTTGGG/AACAGG 2 -- ut31 ese35Minor allele frequency- A:0.08EA EU WA 1700
rs10524871,2
F117701250(+) TCACCA/CCAAGG 2 -- ut31 ese31Minor allele frequency- C:0.01MN 184
rs20770321,2
F117693260(-) TGTGTT/ATCCCG 2 -- ng513Minor allele frequency- A:0.07NA EA 244
rs131946101,2
A,C,F,H117698448(+) TGGAAT/CAGCGC 2 N/N syn1 int1 ese34Minor allele frequency- C:0.17EU EA WA 418
rs7069501,2
A,C,F,H117694261(-) ATAAAA/GCTGCG 2 -- int15Minor allele frequency- G:0.38MN EU EA WA 602
rs7069531,2
A,C,F117695524(-) CCCTGA/CAACTA 2 -- int11Minor allele frequency- C:0.31MN 184
rs4334251,2
A,C,F117693747(+) CCCCGT/CTTGCG 2 -- int11Minor allele frequency- C:0.38MN 184
About this table

HapMap Linkage Disequilibrium images for VGLL2 (up to first 250kb)

Disorders & Mutations
for VGLL2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 609979

Medical News
for VGLL2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for VGLL2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/11 PubMed articles for VGLL2 gene (see all 11 ):

Search for VGLL2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing VGLL2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 245806 HGNC: 20232 AceView: VGLL2 Ensembl:ENSG00000170162 euGenes: HUgn245806
ECgene: VGLL2 H-InvDB: VGLL2

Other Databases showing VGLL2

(According to HUGE)
About This Section

   --

Specialized Databases showing VGLL2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for VGLL2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for VGLL2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for VGLL2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VGLL2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for VGLL2 Antibodies for VGLL2
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for VGLL2 Browse small molecules at Sigma-Aldrich
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 Antibodies for VGLL2

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