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Aliases for VGLL2 Gene

Aliases for VGLL2 Gene

  • Vestigial Like Family Member 2 2 3 5
  • VITO1 3 4
  • Transcription Cofactor Vestigial-Like Protein 2 3
  • Vestigial And Tondu Related Protein 1 3
  • Vestigial-Like Family Member 2 2
  • Vestigial Like 2 (Drosophila) 2
  • Vestigial Like 2 3
  • Protein VITO1 4
  • Vgl-2 4
  • VGL2 3

External Ids for VGLL2 Gene

Previous GeneCards Identifiers for VGLL2 Gene

  • GC06P117586
  • GC06P117632
  • GC06P117693
  • GC06P115167

Summaries for VGLL2 Gene

Entrez Gene Summary for VGLL2 Gene

  • This gene encodes a protein with a transcriptional enhancer factor 1 (TEF-1) interaction domain. The encoded protein may act as a co-factor of TEF-1 regulated gene expression during skeletal muscle development. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

GeneCards Summary for VGLL2 Gene

VGLL2 (Vestigial Like Family Member 2) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is VGLL3.

UniProtKB/Swiss-Prot for VGLL2 Gene

  • May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGLL2 Gene

Genomics for VGLL2 Gene

Regulatory Elements for VGLL2 Gene

Enhancers for VGLL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G117264 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.9 +2.3 2270 6.6 FEZF1 ZNF2 GLIS2 ZNF366 SCRT2 EGR2 ZNF263 ZNF680 SP3 ZEB2 VGLL2 KPNA5 RN7SKP18
GH06G117272 1.2 Ensembl ENCODE dbSUPER 13.4 +7.2 7186 1.7 SUZ12 MAFG CBX2 ZFHX2 ZNF316 ZNF366 CUX1 EMSY MAFK PRDM1 VGLL2 RN7SKP18
GH06G117165 1.2 Ensembl ENCODE dbSUPER 7.8 -97.4 -97449 4.9 CTCF PKNOX1 FEZF1 ZIC2 HIC1 ZNF366 ZNF600 FOS BHLHE40 ZEB2 VGLL2 NEPNP GC06M117235 RNA5SP214
GH06G117287 0.7 dbSUPER 11.8 +24.2 24231 4.7 SCRT1 ZBTB21 ATF2 ZNF7 ZNF579 GATA3 ZNF692 ZBTB33 PRDM10 ZBTB20 VGLL2 RN7SKP18
GH06G117231 0.5 ENCODE 16.4 -33.0 -33015 2.5 ZFHX2 CEBPA IKZF1 JUNB CEBPB VGLL2 GC06M117235 RNA5SP214
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VGLL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for VGLL2 Gene

117,265,558 bp from pter
117,273,565 bp from pter
8,008 bases
Plus strand

Genomic View for VGLL2 Gene

Genes around VGLL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGLL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGLL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGLL2 Gene

Proteins for VGLL2 Gene

  • Protein details for VGLL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription cofactor vestigial-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8WWX1

    Protein attributes for VGLL2 Gene

    317 amino acids
    Molecular mass:
    33426 Da
    Quaternary structure:
    • Interacts with TEFs. Binds to TEAD1/TEF1.

    Alternative splice isoforms for VGLL2 Gene


neXtProt entry for VGLL2 Gene

Post-translational modifications for VGLL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VGLL2 Gene

No data available for DME Specific Peptides for VGLL2 Gene

Domains & Families for VGLL2 Gene

Gene Families for VGLL2 Gene

Protein Domains for VGLL2 Gene


Suggested Antigen Peptide Sequences for VGLL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the vestigial family.
  • Belongs to the vestigial family.
genes like me logo Genes that share domains with VGLL2: view

Function for VGLL2 Gene

Molecular function for VGLL2 Gene

UniProtKB/Swiss-Prot Function:
May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.

Gene Ontology (GO) - Molecular Function for VGLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003705 contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA --
GO:0003713 transcription coactivator activity IBA,IEA --
GO:0005515 protein binding IPI 25416956
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with VGLL2: view
genes like me logo Genes that share phenotypes with VGLL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for VGLL2 Gene

Localization for VGLL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGLL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VGLL2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for VGLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with VGLL2: view

Pathways & Interactions for VGLL2 Gene

SuperPathways for VGLL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VGLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007519 skeletal muscle tissue development IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IBA --
genes like me logo Genes that share ontologies with VGLL2: view

No data available for Pathways by source and SIGNOR curated interactions for VGLL2 Gene

Drugs & Compounds for VGLL2 Gene

No Compound Related Data Available

Transcripts for VGLL2 Gene

mRNA/cDNA for VGLL2 Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for VGLL2 Gene

Vestigial like 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for VGLL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP2: -

Relevant External Links for VGLL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VGLL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VGLL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VGLL2 Gene

This gene is overexpressed in Muscle - Skeletal (x48.1).

NURSA nuclear receptor signaling pathways regulating expression of VGLL2 Gene:


SOURCE GeneReport for Unigene cluster for VGLL2 Gene:


mRNA Expression by UniProt/SwissProt for VGLL2 Gene:

Tissue specificity: Skeletal muscle.

Evidence on tissue expression from TISSUES for VGLL2 Gene

  • Muscle(4.6)
genes like me logo Genes that share expression patterns with VGLL2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for VGLL2 Gene

Orthologs for VGLL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for VGLL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VGLL2 34 35
  • 99.47 (n)
(Canis familiaris)
Mammalia VGLL2 34 35
  • 91.56 (n)
(Bos Taurus)
Mammalia VGLL2 34 35
  • 88.89 (n)
(Mus musculus)
Mammalia Vgll2 34 16 35
  • 85.88 (n)
(Rattus norvegicus)
Mammalia Vgll2 34
  • 85.39 (n)
(Monodelphis domestica)
Mammalia VGLL2 35
  • 68 (a)
(Gallus gallus)
Aves VGLL2 34 35
  • 74.28 (n)
(Anolis carolinensis)
Reptilia VGLL2 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vgll2 34
  • 65.59 (n)
MGC75898 34
African clawed frog
(Xenopus laevis)
Amphibia vgll2-prov 34
(Danio rerio)
Actinopterygii si:dkeyp-93d12.1 34
  • 68.66 (n)
vgll2a 35
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4737 34
fruit fly
(Drosophila melanogaster)
Insecta vg 35
  • 14 (a)
Species where no ortholog for VGLL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VGLL2 Gene

Gene Tree for VGLL2 (if available)
Gene Tree for VGLL2 (if available)

Paralogs for VGLL2 Gene

Paralogs for VGLL2 Gene

genes like me logo Genes that share paralogs with VGLL2: view

Variants for VGLL2 Gene

Sequence variations from dbSNP and Humsavar for VGLL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000168985 -- 117,264,266(+) TTAAT(C/G)CTCCC intron-variant, upstream-variant-2KB
rs1000544443 -- 117,263,910(+) TGCAT(A/G)GAAAT intron-variant, upstream-variant-2KB
rs1000908212 -- 117,265,371(+) ACCCT(A/T)GGCCG upstream-variant-2KB
rs1001805968 -- 117,263,746(+) AAATG(A/T)TGATA intron-variant, upstream-variant-2KB
rs1001875462 -- 117,269,717(+) TAAAC(A/G)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VGLL2 Gene

Variant ID Type Subtype PubMed ID
esv2759465 CNV loss 17122850
nsv830785 CNV gain 17160897
nsv950498 CNV deletion 24416366

Variation tolerance for VGLL2 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VGLL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGLL2 Gene

Disorders for VGLL2 Gene

Relevant External Links for VGLL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for VGLL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VGLL2 Gene

Publications for VGLL2 Gene

  1. Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. (PMID: 12376544) Maeda T. … Stewart A.F.R. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases. (PMID: 26501226) Alaggio R. … Antonescu C.R. (Am. J. Surg. Pathol. 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Genotype-phenotype correlation in interstitial 6q deletions: a report of 12 new cases. (PMID: 22218741) Rosenfeld J.A. … Shaffer L.G. (Neurogenetics 2012) 3 64

Products for VGLL2 Gene

Sources for VGLL2 Gene

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