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Aliases & Descriptions for VGLL1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000024123 2 | | TDU 1, 2, 3, 5 | | TONDU 1, 2 | | VGL1 2, 5 | | Vgl-1 3 | | WUGSC:H_GS188P18.1b 2 |
| | | Descriptions |
|---|
| Protein TONDU 3 | | vestigial like 1 2 | | vestigial like 1 (Drosophila) 2 |
|
| | Search outside databases for aliases for VGLL1 genePrevious GC identifers: GC0XP133559 GC0XP134319 GC0XP135339 |
Summaries for VGLL1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VGLL1_HUMAN, Q99990Function: May act as a specific coactivator for the mammalian TEFs |
Genomic Location for VGLL1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VGLL1 gene 
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3VGLL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP135441:
(about GC identifiers)
Start:
|
135,441,977 bp from pter |
End:
|
135,466,629 bp from pter |
Size:
|
24,653 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011786.15
| Proteins for VGLL1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VGLL1_HUMAN, Q99990 (See
protein sequence)Recommended Name: Transcription cofactor vestigial-like protein 1 Size: 258 amino acids; 28707 Da
Subunit: Interacts with TEFs
Subcellular location: NucleusREFSEQ proteins: NP_057351.1
ENSEMBL proteins: ENSP00000359668
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for VGLL1: Assays for VGLL1: | Protein
Domains/ Families for VGLL1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q99990
ProtoNet protein and cluster: Q99990 1 Blocks protein family: IPB011520 Vestigial/tondu
UniProtKB/Swiss-Prot: VGLL1_HUMAN, Q99990Similarity: Belongs to the vestigial family | Gene Function for VGLL1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016267
Applied Biosystems Silencer® siRNAs for VGLL1
Sigma-Aldrich siRNA for VGLL1  Sigma-Aldrich shRNA for VGLL1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016267                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016267                                  untagged cDNA clone in CMV expression vector: NM_016267 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016267
UniProtKB/Swiss-Prot: VGLL1_HUMAN, Q99990Function: May act as a specific coactivator for the mammalian TEFs2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003713 | transcription coactivator activity |
TAS | 10518497 | | GO:0030528 | transcription regulator activity |
IEA | -- | About this table | Pathways & Interactions for VGLL1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VGLL1 
3 Interacting proteins for VGLL1 (ENSP000003596683) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 10518497 | About this table
|
Drugs & Compounds for VGLL1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VGLL1
|
Transcripts for VGLL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016267
Sigma-Aldrich siRNA for VGLL1  Sigma-Aldrich shRNA for VGLL1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016267 REFSEQ mRNAs for VGLL1 gene: NM_016267.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016267               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016267                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016267                                  untagged cDNA clone in CMV expression vector: NM_016267  Additional cDNA sequence: AF137387.1 AK309912.1 BC000045.1 BC003362.1 CR590059.1 CR595192.1 CR602014.1 CR607030.1 CR608272.1 CR608710.1 CR609159.1 CR610361.1 CR611631.1 CR612495.1 CR614664.1 CR619873.1 CR625530.1 4 DOTS entries: DT.451550 DT.86802990 DT.97840907 DT.40107609 24/142 AceView cDNA sequences (see all 142
):CR614664 AL544599 BM844553 CR610361 CR612495 AI871871 CA311702 CR611631 AL551760 BE535201 BI087731 BE731137 NM_016267 BC003362 CR608272 AI142461 CR602014 AI142456 CR625530 CR590059 CR609159 BC000045 CR595192 AI383337
highest scoring ESTs for VGLL1:AA505326 AA524341 AA614529 AA642211 AA700322 AA707147 AF137387 AI091425 AI142456 AI142461 Unigene Cluster for VGLL1: Vestigial like 1 (Drosophila) Hs.496843 [show with all ESTs]Unigene Representative Sequence: NM_016267
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for VGLL1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VGLL1
1 Ensembl transcript including schematic representation: ENST00000370634
|
Expression for VGLL1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VGLL1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VGLL1
1 / 2 / 3 5 probe-sets matching VGLL1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCTGTGAATC
SOURCE GeneReport for Unigene cluster: Hs.496843
Expression variation in blood from EXPOLDB for VGLL1 |
Orthologs for VGLL1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VGLL1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for VGLL1
ENSEMBL Gene Tree for VGLL1 | Paralogs for VGLL1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for VGLL1 gene
- VGLL32 VGLL22
|
SNPs/Variants for VGLL1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VGLL1 (up to first 250kb)
|
Disorders & Mutations for VGLL1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300583
|
Medical News for VGLL1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VGLL1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for VGLL1 gene:- TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation. (PubMed id 10518497)1, 2, 3, 4 Vaudin P.... Zider A. (1999)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)3, 4 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. (PubMed id 12376544)1 Maeda T.... Stewart A.F. (2002)
- The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. (PubMed id 15628970)1 Mahoney W.M....Farrance I.K. (2005)
- VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. (PubMed id 14516696)1 Mielcarek M....Braun T. (2002)
- VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. (PubMed id 12617818)1 Mielcarek M.... Braun T. (2002)
|
Search for VGLL1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VGLL1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VGLL1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VGLL1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VGLL1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VGLL1:

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Incremental update: 13 Oct 2009
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