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Aliases for VGLL1 Gene

Aliases for VGLL1 Gene

  • Vestigial-Like Family Member 1 2 3
  • TDU 3 4 6
  • Vgl-1 3 4
  • VGL1 3 6
  • Transcription Cofactor Vestigial-Like Protein 1 3
  • Vestigial Like 1 (Drosophila) 2
  • WUGSC:H_GS188P18.1b 3
  • Vestigial Like 1 3
  • Protein TONDU 4
  • TONDU 3

External Ids for VGLL1 Gene

Summaries for VGLL1 Gene

Entrez Gene Summary for VGLL1 Gene

  • The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]

GeneCards Summary for VGLL1 Gene

VGLL1 (Vestigial-Like Family Member 1) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for VGLL1 Gene

  • May act as a specific coactivator for the mammalian TEFs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGLL1 Gene

Genomics for VGLL1 Gene

Genomic Location for VGLL1 Gene

136,532,152 bp from pter
136,556,807 bp from pter
24,656 bases
Plus strand

Genomic View for VGLL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VGLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGLL1 Gene

Regulatory Elements for VGLL1 Gene

Proteins for VGLL1 Gene

  • Protein details for VGLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription cofactor vestigial-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5H915

    Protein attributes for VGLL1 Gene

    258 amino acids
    Molecular mass:
    28707 Da
    Quaternary structure:
    • Interacts with TEFs.

neXtProt entry for VGLL1 Gene

Proteomics data for VGLL1 Gene at MOPED

Post-translational modifications for VGLL1 Gene

No Post-translational modifications

Other Protein References for VGLL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VGLL1 Gene

Domains for VGLL1 Gene

Protein Domains for VGLL1 Gene



  • Belongs to the vestigial family.:
    • Q99990
genes like me logo Genes that share domains with VGLL1: view

No data available for Gene Families for VGLL1 Gene

Function for VGLL1 Gene

Molecular function for VGLL1 Gene

UniProtKB/Swiss-Prot Function: May act as a specific coactivator for the mammalian TEFs.

Gene Ontology (GO) - Molecular Function for VGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 10518497
genes like me logo Genes that share ontologies with VGLL1: view

Phenotypes for VGLL1 Gene

GenomeRNAi human phenotypes for VGLL1:
genes like me logo Genes that share phenotypes with VGLL1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for VGLL1 Gene

Localization for VGLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGLL1 Gene

Subcellular locations from

Jensen Localization Image for VGLL1 Gene COMPARTMENTS Subcellular localization image for VGLL1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for VGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10518497
genes like me logo Genes that share ontologies with VGLL1: view

Pathways for VGLL1 Gene

SuperPathways for VGLL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10518497
genes like me logo Genes that share ontologies with VGLL1: view

No data available for Pathways by source for VGLL1 Gene

Transcripts for VGLL1 Gene

mRNA/cDNA for VGLL1 Gene

Unigene Clusters for VGLL1 Gene

Vestigial like 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VGLL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - -

Relevant External Links for VGLL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for VGLL1 Gene

mRNA expression in normal human tissues for VGLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VGLL1 Gene

This gene is overexpressed in Bladder (26.4), Minor Salivary Gland (6.1), and Breast - Mammary Tissue (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VGLL1 Gene

SOURCE GeneReport for Unigene cluster for VGLL1 Gene Hs.496843

genes like me logo Genes that share expressions with VGLL1: view

Orthologs for VGLL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VGLL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VGLL1 36
  • 98.69 (n)
  • 98.25 (a)
VGLL1 37
  • 98 (a)
(Bos Taurus)
Mammalia VGLL1 36
  • 81.27 (n)
  • 67.62 (a)
VGLL1 37
  • 62 (a)
(Canis familiaris)
Mammalia VGLL1 36
  • 79.78 (n)
  • 63.03 (a)
VGLL1 37
  • 59 (a)
(Mus musculus)
Mammalia Vgll1 36
  • 71.93 (n)
  • 53.51 (a)
Vgll1 16
Vgll1 37
  • 39 (a)
(Monodelphis domestica)
Mammalia VGLL1 37
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia VGLL1 37
  • 46 (a)
(Rattus norvegicus)
Mammalia Vgll1 36
  • 72.08 (n)
  • 55.26 (a)
(Gallus gallus)
Aves VGLL1 36
  • 57.56 (n)
  • 45.88 (a)
VGLL1 37
  • 45 (a)
(Anolis carolinensis)
Reptilia VGLL1 37
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vgll1 36
  • 51.4 (n)
  • 36.87 (a)
Species with no ortholog for VGLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VGLL1 Gene

Gene Tree for VGLL1 (if available)
Gene Tree for VGLL1 (if available)

Paralogs for VGLL1 Gene

Selected SIMAP similar genes for VGLL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VGLL1: view

No data available for Paralogs for VGLL1 Gene

Variants for VGLL1 Gene

Sequence variations from dbSNP and Humsavar for VGLL1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs9119 -- 136,556,664(+) AGCTT(C/T)GTGTC utr-variant-3-prime
rs1014623 -- 136,545,335(-) TGCAC(A/C)GTTGC intron-variant
rs1210106 -- 136,540,618(+) ttgta(G/T)ttctt intron-variant
rs2071911 -- 136,556,811(-) AACCC(A/G)GCATA downstream-variant-500B
rs2106161 -- 136,545,437(+) TTGGG(A/G)ATATA intron-variant

Relevant External Links for VGLL1 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Structural Variations from Database of Genomic Variants (DGV) for VGLL1 Gene

Disorders for VGLL1 Gene

No disorders were found for VGLL1 Gene.

No data available for UniProtKB/Swiss-Prot for VGLL1 Gene

Publications for VGLL1 Gene

  1. TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation. (PMID: 10518497) Vaudin P. … Zider A. (Development 1999) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. VGLL1 expression is associated with a triple-negative basal-like phenotype in breast cancer. (PMID: 24891455) Castilla M.A.8. … Palacios J. (Endocr. Relat. Cancer 2014) 3
  5. Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. (PMID: 12376544) Maeda T. … Stewart A.F.R. (J. Biol. Chem. 2002) 23

Products for VGLL1 Gene

Sources for VGLL1 Gene

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