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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VGLL1 Gene

protein-coding GIFtS: 49
GCID: GC0XP135614

vestigial like 1 (Drosophila)

Search for VGLL1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Vestigial Like 1 (Drosophila)¹ ²		Transcription Cofactor Vestigial-Like Protein 1²
TDU¹ ² ³ ⁵		Vgl-1³
TONDU¹ ²		Vgl-1³
VGL1² ⁵		Protein TONDU³
WUGSC:H_GS188P18.1b²

External Ids:	HGNC: 20985¹	Entrez Gene: 51442²	Ensembl: ENSG00000102243⁷	OMIM: 300583⁵	UniProtKB: Q99990³

Export aliases for VGLL1 gene to outside databases

Previous GC identifers: GC0XP133559 GC0XP134319 GC0XP135339 GC0XP135441 GC0XP124884

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VGLL1:

The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg

(vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian

TEFs. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: VGLL1_HUMAN, Q99990

Function: May act as a specific coactivator for the mammalian TEFs

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VGLL1 gene promoter:
Sox5 Pbx1a Lmo2 FOXD3 Max AREB6 SRY Ik-2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VGLL1 promoter sequence

Search SABiosciences Chromatin IP Primers for VGLL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VGLL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3

VGLL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VGLL1 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP135614: view genomic region (about GC identifiers)

Start:	135,614,311 bp from pter	End:	135,638,966 bp from pter
Size:	24,656 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VGLL1_HUMAN, Q99990 (See protein sequence)

Recommended Name: Transcription cofactor vestigial-like protein 1

Size: 258 amino acids; 28707 Da

Subunit: Interacts with TEFs

Subcellular location: Nucleus

Secondary accessions: Q5H915

Explore the universe of human proteins at neXtProt for VGLL1: NX_Q99990

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99990

VGLL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057351.1

ENSEMBL proteins:

ENSP00000359668 ENSP00000398360 ENSP00000388868

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	10518497

VGLL1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VGLL1 for domains About GeneDecksing

2 InterPro domains/families:

IPR006627 TDU_repeat

IPR011520 Vg_Tdu

Graphical View of Domain Structure for InterPro Entry Q99990

ProtoNet protein and cluster: Q99990

1 Blocks protein family: IPB011520 Vestigial/tondu

UniProtKB/Swiss-Prot: VGLL1_HUMAN, Q99990

Similarity: Belongs to the vestigial family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: VGLL1_HUMAN, Q99990

Function: May act as a specific coactivator for the mammalian TEFs

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	TAS	10518497

VGLL1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for VGLL1:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VGLL1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for VGLL1 (Q99990³ ENSP00000359668⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TEAD1	P28347³, ENSP00000354588⁴	I2D: score=1 STRING: ENSP00000354588
TEAD4	Q15561³, ENSP00000352926⁴	I2D: score=2 STRING: ENSP00000352926
TEAD2	Q15562³, ENSP00000310701⁴	I2D: score=1 STRING: ENSP00000310701
TEAD3	Q99594³, ENSP00000345772⁴	I2D: score=2 STRING: ENSP00000345772

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	10518497

VGLL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for VGLL1
Search CenterWatch for drugs/clinical trials and news about VGLL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for VGLL1 gene:

NM_016267.3

Unigene Cluster for VGLL1:

Vestigial like 1 (Drosophila)

Hs.496843 [show with all ESTs]

Unigene Representative Sequence: NM_016267

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370634(uc004ezy.3) ENST00000440515 ENST00000456412 ENST00000470358

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Additional cDNA sequence:

AF137387.1 AK309912.1 BC000045.1 BC003362.1

4 DOTS entries:

DT.451550 DT.86802990 DT.97840907 DT.40107609

24/142 AceView cDNA sequences (see all 142):

CR612495 CR607030 BC000045 AL544599 BM797250 CR619873 BE535201 BE731137

CR595192 NM_016267 BX337420 AI383337 AI142461 CR625530 BM724354 AI142456

BI087731 BC003362 AL551760 CR609159 CR602014 CA311702 CR614664 CR608272

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for VGLL1 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:											-
SP2:									-		-
SP3:

ECgene alternative splicing isoforms for VGLL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VGLL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGTGAATC

About this image

VGLL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See VGLL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VGLL1

SOURCE GeneReport for Unigene cluster: Hs.496843

SABiosciences Custom PCR Arrays for VGLL1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for VGLL1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	VGLL1⁶	Uncharacterized protein	47(a)	1 ↔ 1	4(4360259-4362663)
lizard (Anolis carolinensis)	Reptilia	VGLL1⁶	--	49(a)	1 ↔ 1	GL343562.1(171769-171957)
tropical clawed frog (Xenopus tropicalis)	Amphibia	142005941²	--	72.53(n)		142005941
zebrafish (Danio rerio)	Actinopterygii	vgll2b⁶	vestigial like 2b	18(a)	1 ↔ 1	17(27293547-27306448)

ENSEMBL Gene Tree for VGLL1 (if available)
TreeFam Gene Tree for VGLL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VGLL1 gene

VGLL3² VGLL2²

1 SIMAP similar gene for VGLL1 using alignment to 3 protein entries: VGLL1_HUMAN (see all proteins):

WUGSC

VGLL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192806722^1,2		--	135612327(+)	`AAGTCA/GGGATA`	1	--	us2k¹		0	--	--	--	--
rs147000842^1,2		--	135612418(+)	`TGTGTC/GTGTGT`	1	--	us2k¹		0	--	--	--	--
rs185881826^1,2		--	135612450(+)	`GCTCTA/GTCACC`	1	--	us2k¹		0	--	--	--	--
rs138217808^1,2		--	135612517(+)	`CAAGCG/TATCCT`	1	--	us2k¹		0	--	--	--	--
rs112097312^1,2	C,	--	135612760(+)	`TAGCTG/ATTTTG`	1	--	us2k¹		1		CSA	1
rs145925421^1,2		--	135612772(+)	`AATACA/TTAATA`	1	--	us2k¹		0	--	--	--	--
rs138616121^1,2		--	135613191(+)	`TTCAGA/GATATG`	1	--	us2k¹		0	--	--	--	--
rs190357273^1,2		--	135613217(+)	`AACCCC/TTCTGG`	1	--	us2k¹		0	--	--	--	--
rs149364999^1,2		--	135613462(+)	`ACCTTA/GTCAGA`	1	--	us2k¹		0	--	--	--	--
rs180977191^1,2		--	135613710(+)	`CAGTTC/GGCATT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VGLL1 (135614311 - 135638966 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VGLL1: --
Locus Specific Mutation Databases (LSDB): VGLL1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VGLL1 for disorders About MalaCards

VGLL1 for disorders About GeneDecksing

OMIM gene information: 300583 OMIM disorders: --

Export disorders for VGLL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VGLL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with VGLL1)

Utopia: connect your pdf to the dynamic
world of online information

TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation. (PubMed id 10518497)^{1, 2, 3, 9} Vaudin P.... Zider A. (1999)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. (PubMed id 12376544)⁹ Maeda T.... Stewart A.F. (2002)
The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. (PubMed id 15628970)⁹ Mahoney W.M....Farrance I.K. (2005)
VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. (PubMed id 14516696)⁹ Mielcarek M....Braun T. (2002)
VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. (PubMed id 12617818)⁹ Mielcarek M.... Braun T. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51442	HGNC: 20985	AceView: VGLL1	Ensembl:ENSG00000102243	euGenes: HUgn51442
ECgene: VGLL1	H-InvDB: VGLL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VGLL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for VGLL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for VGLL1 gene:
Search GeneIP for patents involving VGLL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VGLL1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VGLL1
	OriGene Protein Over-expression Lysate for VGLL1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for VGLL1		OriGene 3'-UTR Clone for VGLL1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VGLL1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VGLL1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for VGLL1		OriGene Custom Protein Services for VGLL1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VGLL1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VGLL1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VGLL1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VGLL1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VGLL1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VGLL1

	GenScript Custom Purified and Recombinant Proteins Services for VGLL1		GenScript cDNA clones with any tag delivered in your preferred vector for VGLL1
	GenScript Custom Assay Services for VGLL1		GenScript Custom Superior Antibodies Services for VGLL1
	GenScript Custom overexpressing Cell Line Services for VGLL1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VGLL1

	SwitchGear 3'UTR luciferase reporter plasmids for VGLL1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VGLL1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes VGLL1 gene at Home site.

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VGLL1 Gene

vestigial like 1 (Drosophila)

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VGLL1 Gene

vestigial like 1 (Drosophila)

Aliasesfor VGLL1 gene

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Genomic Viewsfor VGLL1 gene

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