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Aliases for VGLL1 Gene

Aliases for VGLL1 Gene

  • Vestigial Like Family Member 1 2 3 5
  • Vgl-1 3 4
  • TDU 3 4
  • Transcription Cofactor Vestigial-Like Protein 1 3
  • Vestigial-Like Family Member 1 2
  • Vestigial Like 1 (Drosophila) 2
  • WUGSC:H_GS188P18.1b 3
  • Vestigial Like 1 3
  • Protein TONDU 4
  • TONDU 3
  • VGL1 3

External Ids for VGLL1 Gene

Previous GeneCards Identifiers for VGLL1 Gene

  • GC0XP133559
  • GC0XP134319
  • GC0XP135339
  • GC0XP135441
  • GC0XP135614
  • GC0XP124884

Summaries for VGLL1 Gene

Entrez Gene Summary for VGLL1 Gene

  • The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]

GeneCards Summary for VGLL1 Gene

VGLL1 (Vestigial Like Family Member 1) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for VGLL1 Gene

  • May act as a specific coactivator for the mammalian TEFs.

Additional gene information for VGLL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGLL1 Gene

Genomics for VGLL1 Gene

Regulatory Elements for VGLL1 Gene

Enhancers for VGLL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH136584 1.1 FANTOM5 ENCODE dbSUPER 13.2 +55.0 54955 4 BCL11A CEBPB JUNB CEBPG BATF MIR934 VGLL1 ARHGEF6 CD40LG GPR101 RNU6-320P LINC00892
GH0XH136525 0.8 Ensembl ENCODE 0.4 -5.9 -5930 1 JUND MAFG FOS NFE2 MIR934 VGLL1 HTATSF1
GH0XH136495 1 ENCODE 0.3 -34.9 -34931 2 FOXA2 ATF1 SIN3A ZNF2 YY1 GTF3C2 GLIS2 KLF7 SP3 ZHX2 SRRM1P3 RBMX LOC100420958 MAP7D3 HTATSF1 VGLL1
GH0XH136533 0.4 ENCODE 0.7 +1.3 1278 0 TAL1 VGLL1 MIR934
GH0XH136531 0.4 ENCODE 0.7 -0.1 -125 0 ZSCAN29 VGLL1 HTATSF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VGLL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for VGLL1 Gene

Chromosome:
X
Start:
136,532,152 bp from pter
End:
136,556,807 bp from pter
Size:
24,656 bases
Orientation:
Plus strand

Genomic View for VGLL1 Gene

Genes around VGLL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGLL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGLL1 Gene

Proteins for VGLL1 Gene

  • Protein details for VGLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99990-VGLL1_HUMAN
    Recommended name:
    Transcription cofactor vestigial-like protein 1
    Protein Accession:
    Q99990
    Secondary Accessions:
    • Q5H915

    Protein attributes for VGLL1 Gene

    Size:
    258 amino acids
    Molecular mass:
    28707 Da
    Quaternary structure:
    • Interacts with TEFs.

neXtProt entry for VGLL1 Gene

Post-translational modifications for VGLL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VGLL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VGLL1 Gene

Domains & Families for VGLL1 Gene

Gene Families for VGLL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for VGLL1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99990

UniProtKB/Swiss-Prot:

VGLL1_HUMAN :
  • Belongs to the vestigial family.
Family:
  • Belongs to the vestigial family.
genes like me logo Genes that share domains with VGLL1: view

Function for VGLL1 Gene

Molecular function for VGLL1 Gene

UniProtKB/Swiss-Prot Function:
May act as a specific coactivator for the mammalian TEFs.

Gene Ontology (GO) - Molecular Function for VGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003705 contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IBA --
GO:0003713 transcription coactivator activity TAS 10518497
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with VGLL1: view
genes like me logo Genes that share phenotypes with VGLL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VGLL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for VGLL1 Gene

Localization for VGLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGLL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VGLL1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for VGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,NAS 10518497
genes like me logo Genes that share ontologies with VGLL1: view

Pathways & Interactions for VGLL1 Gene

SuperPathways for VGLL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS,IEA 10518497
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with VGLL1: view

No data available for Pathways by source and SIGNOR curated interactions for VGLL1 Gene

Drugs & Compounds for VGLL1 Gene

No Compound Related Data Available

Transcripts for VGLL1 Gene

Unigene Clusters for VGLL1 Gene

Vestigial like 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VGLL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for VGLL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3:

Relevant External Links for VGLL1 Gene

GeneLoc Exon Structure for
VGLL1
ECgene alternative splicing isoforms for
VGLL1

Expression for VGLL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VGLL1 Gene

mRNA differential expression in normal tissues according to GTEx for VGLL1 Gene

This gene is overexpressed in Bladder (x26.4), Minor Salivary Gland (x6.1), and Breast - Mammary Tissue (x4.5).

Protein differential expression in normal tissues from HIPED for VGLL1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for VGLL1 Gene



Protein tissue co-expression partners for VGLL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VGLL1 Gene:

VGLL1

SOURCE GeneReport for Unigene cluster for VGLL1 Gene:

Hs.496843
genes like me logo Genes that share expression patterns with VGLL1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for VGLL1 Gene

Orthologs for VGLL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VGLL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VGLL1 33 34
  • 98.69 (n)
cow
(Bos Taurus)
Mammalia VGLL1 33 34
  • 81.27 (n)
dog
(Canis familiaris)
Mammalia VGLL1 33 34
  • 79.78 (n)
rat
(Rattus norvegicus)
Mammalia Vgll1 33
  • 72.08 (n)
mouse
(Mus musculus)
Mammalia Vgll1 33 16 34
  • 71.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VGLL1 34
  • 46 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VGLL1 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves VGLL1 33 34
  • 57.56 (n)
lizard
(Anolis carolinensis)
Reptilia VGLL1 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vgll1 33
  • 51.4 (n)
Species where no ortholog for VGLL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VGLL1 Gene

ENSEMBL:
Gene Tree for VGLL1 (if available)
TreeFam:
Gene Tree for VGLL1 (if available)

Paralogs for VGLL1 Gene

(1) SIMAP similar genes for VGLL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VGLL1: view

No data available for Paralogs for VGLL1 Gene

Variants for VGLL1 Gene

Sequence variations from dbSNP and Humsavar for VGLL1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000046111 -- 136,538,282(+) AGTTA(C/T)ATTTT intron-variant
rs1000053115 -- 136,537,621(+) GTGGC(A/G)CGATC intron-variant
rs1000112802 -- 136,540,329(+) CACCC(A/G)CTCCA intron-variant
rs1000244563 -- 136,548,499(+) AAGTT(-/A)AAAAA intron-variant
rs1000280948 -- 136,545,027(+) GATGA(A/C)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VGLL1 Gene

Variant ID Type Subtype PubMed ID
dgv2478e212 CNV loss 25503493

Variation tolerance for VGLL1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VGLL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VGLL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGLL1 Gene

Disorders for VGLL1 Gene

Relevant External Links for VGLL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VGLL1

No disorders were found for VGLL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VGLL1 Gene

Publications for VGLL1 Gene

  1. TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation. (PMID: 10518497) Vaudin P … Zider A (Development (Cambridge, England) 1999) 2 3 4 22 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. VGLL1 expression is associated with a triple-negative basal-like phenotype in breast cancer. (PMID: 24891455) Castilla MÁ … Palacios J (Endocrine-related cancer 2014) 3 60
  5. The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. (PMID: 15628970) Mahoney WM … Farrance IK (The Biochemical journal 2005) 22 60

Products for VGLL1 Gene

Sources for VGLL1 Gene

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