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Aliases for VGF Gene

Aliases for VGF Gene

  • VGF Nerve Growth Factor Inducible 2 3
  • Neuro-Endocrine Specific Protein VGF 2 3
  • Neurosecretory Protein VGF 3
  • SgVII 3
  • SCG7 3

External Ids for VGF Gene

Previous GeneCards Identifiers for VGF Gene

  • GC07M099289
  • GC07M100352
  • GC07M100365
  • GC07M100401
  • GC07M100592
  • GC07M100805
  • GC07M095398

Summaries for VGF Gene

Entrez Gene Summary for VGF Gene

  • This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for VGF Gene

VGF (VGF Nerve Growth Factor Inducible) is a Protein Coding gene. Diseases associated with VGF include pulmonary large cell neuroendocrine carcinoma and vaccinia. GO annotations related to this gene include growth factor activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for VGF Gene

  • May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.

  • NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release

  • Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGF Gene

Genomics for VGF Gene

Regulatory Elements for VGF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VGF Gene

Start:
101,162,509 bp from pter
End:
101,167,581 bp from pter
Size:
5,073 bases
Orientation:
Minus strand

Genomic View for VGF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGF Gene

Proteins for VGF Gene

  • Protein details for VGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15240-VGF_HUMAN
    Recommended name:
    Neurosecretory protein VGF
    Protein Accession:
    O15240
    Secondary Accessions:
    • Q9UDW8

    Protein attributes for VGF Gene

    Size:
    615 amino acids
    Molecular mass:
    67258 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VGF Gene

Proteomics data for VGF Gene at MOPED

Post-translational modifications for VGF Gene

  • Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
  • Glycosylation at Thr180, Thr187, Thr189, Thr191, Thr193, Ser252, Ser253, Thr256, Ser266, and Thr554
  • Modification sites at PhosphoSitePlus

Other Protein References for VGF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VGF Gene

Domains for VGF Gene

Protein Domains for VGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VGF: view

No data available for Gene Families and UniProtKB/Swiss-Prot for VGF Gene

Function for VGF Gene

Molecular function for VGF Gene

GENATLAS Biochemistry: neurotrophin responsive factor,70kDa,expressed in the brain,with a C terminal region encoding posttranslationaly processed peptides
UniProtKB/Swiss-Prot Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.
UniProtKB/Swiss-Prot Function: NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release
UniProtKB/Swiss-Prot Function: Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris

Gene Ontology (GO) - Molecular Function for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005184 neuropeptide hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with VGF: view
genes like me logo Genes that share phenotypes with VGF: view

Animal Models for VGF Gene

MGI Knock Outs for VGF:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for VGF Gene

Localization for VGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGF Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VGF Gene COMPARTMENTS Subcellular localization image for VGF gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 15706611
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IDA 17440014
genes like me logo Genes that share ontologies with VGF: view

Pathways for VGF Gene

SuperPathways for VGF Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Neurotrophins & Receptors in human,mouse,rat

Interacting Proteins for VGF Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000249330%0d%0a9606.ENSP00000356480%0d%0a9606.ENSP00000316578%0d%0a9606.ENSP00000355865%0d%0a
Selected Interacting proteins: ENSP00000249330 O15240-VGF_HUMAN for VGF Gene via STRING I2D

Gene Ontology (GO) - Biological Process for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0002021 response to dietary excess IEA --
GO:0006091 generation of precursor metabolites and energy IEA --
GO:0009409 response to cold IEA --
GO:0019953 sexual reproduction IEA --
genes like me logo Genes that share ontologies with VGF: view

No data available for Pathways by source for VGF Gene

Compounds for VGF Gene

(5) Novoseek inferred chemical compound relationships for VGF Gene

Compound -log(P) Hits PubMed IDs
forskolin 25.8 2
cyclic amp 23.4 1
tyrosine 16.2 4
thymidine 14.2 2
vegf 0 1
genes like me logo Genes that share compounds with VGF: view

Transcripts for VGF Gene

Unigene Clusters for VGF Gene

VGF nerve growth factor inducible:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VGF

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VGF Gene

No ASD Table

Relevant External Links for VGF Gene

GeneLoc Exon Structure for
VGF
ECgene alternative splicing isoforms for
VGF

Expression for VGF Gene

mRNA expression in normal human tissues for VGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for VGF Gene

This gene is overexpressed in Brain - Hypothalamus (14.2), Pituitary (7.9), Brain - Anterior cingulate cortex (BA24) (5.0), Brain - Cortex (4.7), and Brain - Frontal Cortex (BA9) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VGF Gene

SOURCE GeneReport for Unigene cluster for VGF Gene Hs.587325

mRNA Expression by UniProt/SwissProt for VGF Gene

O15240-VGF_HUMAN
Tissue specificity: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
genes like me logo Genes that share expressions with VGF: view

In Situ Assay Products

Orthologs for VGF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VGF 35
  • 99.51 (n)
  • 99.19 (a)
VGF 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VGF 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VGF 35
  • 90.41 (n)
  • 91.71 (a)
VGF 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vgf 35
  • 84.67 (n)
  • 84.99 (a)
Vgf 16
Vgf 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VGF 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vgf 35
  • 85.21 (n)
  • 85.32 (a)
rice
(Oryza sativa)
Liliopsida Os.46762 35
Species with no ortholog for VGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VGF Gene

ENSEMBL:
Gene Tree for VGF (if available)
TreeFam:
Gene Tree for VGF (if available)

Paralogs for VGF Gene

No data available for Paralogs for VGF Gene

Variants for VGF Gene

Sequence variations from dbSNP and Humsavar for VGF Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1058351 -- 101,162,715(-) TCCCT(C/T)TGGGG utr-variant-3-prime
rs1064431 -- 101,163,401(-) CGGAA(C/G)CGAAA missense, reference
rs1476627 -- 101,163,784(+) CGCCG(C/T)CTCCT missense, reference
rs2107804 -- 101,162,390(+) CCCCT(C/T)GCCTT downstream-variant-500B
rs2898568 -- 101,167,702(+) AAGAC(A/G)GGCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VGF Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
dgv7409n71 CNV Loss 21882294
esv2752134 CNV Gain 17911159
nsv824241 CNV Gain 20364138

Relevant External Links for VGF Gene

HapMap Linkage Disequilibrium report
VGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGF Gene

Disorders for VGF Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for VGF Gene including...

Search for VGF Gene in MalaCards »

(2) Novoseek inferred disease relationships for VGF Gene

Disease -log(P) Hits PubMed IDs
pheochromocytoma 38.8 3
tumors 0 1

Relevant External Links for VGF

Genetic Association Database (GAD)
VGF
Human Genome Epidemiology (HuGE) Navigator
VGF
genes like me logo Genes that share disorders with VGF: view

No data available for UniProtKB/Swiss-Prot for VGF Gene

Publications for VGF Gene

  1. Cloning, structural organization analysis and chromosomal assignment of the human gene for neurosecretory protein VGF. (PMID: 9344675) Canu N. … Levi A. (Genomics 1997) 2 3 4 23
  2. Molecular cloning and characterization of the human VGF promoter region. (PMID: 9084409) Canu N. … Levi A. (J. Neurochem. 1997) 3 23
  3. Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF. (PMID: 19194657) Toshinai K. … Nakazato M. (Cell. Mol. Life Sci. 2009) 4 23
  4. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. (PMID: 17684500) Wedenoja J. … Peltonen L. (Mol. Psychiatry 2008) 3 23
  5. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PMID: 19598235) Chakrabarti B. … Baron-Cohen S. (Autism Res 2009) 3 48

Products for VGF Gene

Sources for VGF Gene

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