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Aliases for VGF Gene

Aliases for VGF Gene

  • VGF Nerve Growth Factor Inducible 2 3 5
  • Neuro-Endocrine Specific Protein VGF 2 3
  • Neurosecretory Protein VGF 3
  • SgVII 3
  • SCG7 3

External Ids for VGF Gene

Previous GeneCards Identifiers for VGF Gene

  • GC07M099289
  • GC07M100352
  • GC07M100365
  • GC07M100401
  • GC07M100592
  • GC07M100805
  • GC07M095398

Summaries for VGF Gene

Entrez Gene Summary for VGF Gene

  • This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for VGF Gene

VGF (VGF Nerve Growth Factor Inducible) is a Protein Coding gene. Diseases associated with VGF include Pulmonary Large Cell Neuroendocrine Carcinoma and Pheochromocytoma. Gene Ontology (GO) annotations related to this gene include growth factor activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for VGF Gene

  • May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.

  • NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.

  • Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.

Additional gene information for VGF Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGF Gene

Genomics for VGF Gene

GeneHancer (GH) Regulatory Elements for VGF Gene

Promoters and enhancers for VGF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I101165 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +3.4 3408 2.7 PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 VGF AP1S1 NAT16 SRRT STAG3L5P GIGYF1 MOSPD3 TSC22D4 MIR4653
GH07I101169 Enhancer 1.4 Ensembl ENCODE dbSUPER 550.8 -0.2 -165 1.2 SIN3A YBX1 ZNF2 ZBTB7B IRF4 ZNF143 KLF13 SP3 REST SMARCA4 VGF SRRT MEPCE PILRB PPP1R35 GIGYF1 STAG3L5P TRIP6 FBXO24 ZCWPW1
GH07I101166 Promoter/Enhancer 1 EPDnew dbSUPER 550.8 +4.9 4865 0.1 ZFHX2 EGR1 REST EZH2 EGR2 VGF MIR4653
GH07I101171 Enhancer 0.6 ENCODE dbSUPER 550.8 -1.3 -1270 0.1 SUZ12 EZH2 VGF AP1S1 NAT16
GH07I101170 Enhancer 0.6 ENCODE dbSUPER 550.8 -1.0 -1020 0.1 SUZ12 ZBTB12 EZH2 VGF NAT16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around VGF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the VGF gene promoter:

Genomic Locations for VGF Gene

Genomic Locations for VGF Gene
chr7:101,162,509-101,169,935
(GRCh38/hg38)
Size:
7,427 bases
Orientation:
Minus strand
chr7:100,805,790-100,808,874
(GRCh37/hg19)

Genomic View for VGF Gene

Genes around VGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGF Gene

Proteins for VGF Gene

  • Protein details for VGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15240-VGF_HUMAN
    Recommended name:
    Neurosecretory protein VGF
    Protein Accession:
    O15240
    Secondary Accessions:
    • Q9UDW8

    Protein attributes for VGF Gene

    Size:
    615 amino acids
    Molecular mass:
    67258 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VGF Gene

Post-translational modifications for VGF Gene

  • Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
  • Glycosylation at posLast=189189, isoforms=252, isoforms=253, isoforms=256, and isoforms=554

Other Protein References for VGF Gene

Antibody Products

  • Abcam antibodies for VGF

No data available for DME Specific Peptides for VGF Gene

Domains & Families for VGF Gene

Gene Families for VGF Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for VGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VGF: view

No data available for UniProtKB/Swiss-Prot for VGF Gene

Function for VGF Gene

Molecular function for VGF Gene

GENATLAS Biochemistry:
neurotrophin responsive factor,70kDa,expressed in the brain,with a C terminal region encoding posttranslationaly processed peptides
UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.
UniProtKB/Swiss-Prot Function:
NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.
UniProtKB/Swiss-Prot Function:
Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.

Phenotypes From GWAS Catalog for VGF Gene

Gene Ontology (GO) - Molecular Function for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005179 hormone activity IBA --
GO:0005184 neuropeptide hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with VGF: view
genes like me logo Genes that share phenotypes with VGF: view

Animal Models for VGF Gene

MGI Knock Outs for VGF:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VGF Gene

Localization for VGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGF Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VGF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 2
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15706611
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IDA --
GO:0030133 transport vesicle IEA --
genes like me logo Genes that share ontologies with VGF: view

Pathways & Interactions for VGF Gene

No Data Available

Interacting Proteins for VGF Gene

Gene Ontology (GO) - Biological Process for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0002021 response to dietary excess IEA --
GO:0006091 generation of precursor metabolites and energy IEA --
GO:0009409 response to cold IEA --
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with VGF: view

No data available for Pathways by source and SIGNOR curated interactions for VGF Gene

Drugs & Compounds for VGF Gene

(5) Drugs for VGF Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TLQP 21 Pharma VGF-derived peptide 0

(1) Additional Compounds for VGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for VGF Gene

Compound Action Cas Number
TLQP 21 VGF-derived peptide 869988-94-3
genes like me logo Genes that share compounds with VGF: view

Drug Products

Transcripts for VGF Gene

Unigene Clusters for VGF Gene

VGF nerve growth factor inducible:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for VGF Gene

No ASD Table

Relevant External Links for VGF Gene

GeneLoc Exon Structure for
VGF
ECgene alternative splicing isoforms for
VGF

Expression for VGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VGF Gene

mRNA differential expression in normal tissues according to GTEx for VGF Gene

This gene is overexpressed in Brain - Hypothalamus (x14.2), Pituitary (x7.9), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Cortex (x4.7), and Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for VGF Gene

This gene is overexpressed in Cerebrospinal fluid (31.0) and Islet of Langerhans (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VGF Gene



Protein tissue co-expression partners for VGF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VGF Gene:

VGF

SOURCE GeneReport for Unigene cluster for VGF Gene:

Hs.587325

mRNA Expression by UniProt/SwissProt for VGF Gene:

O15240-VGF_HUMAN
Tissue specificity: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.

Evidence on tissue expression from TISSUES for VGF Gene

  • Nervous system(4.7)
  • Pancreas(3.1)
  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with VGF: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VGF Gene

Orthologs for VGF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VGF 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia VGF 33 34
  • 90.41 (n)
cow
(Bos Taurus)
Mammalia VGF 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vgf 33
  • 85.21 (n)
mouse
(Mus musculus)
Mammalia Vgf 33 16 34
  • 84.67 (n)
oppossum
(Monodelphis domestica)
Mammalia VGF 34
  • 63 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.46762 33
Species where no ortholog for VGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VGF Gene

ENSEMBL:
Gene Tree for VGF (if available)
TreeFam:
Gene Tree for VGF (if available)

Paralogs for VGF Gene

No data available for Paralogs for VGF Gene

Variants for VGF Gene

Sequence variations from dbSNP and Humsavar for VGF Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1001211664 -- 101,166,014(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001503187 -- 101,163,518(-) C/G coding_sequence_variant, missense_variant
rs1001673007 -- 101,169,861(-) T/C genic_upstream_transcript_variant, intron_variant
rs1002013828 -- 101,171,210(-) G/T upstream_transcript_variant
rs1002182315 -- 101,164,973(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for VGF Gene

Variant ID Type Subtype PubMed ID
dgv11534n54 CNV loss 21841781
esv2422376 CNV duplication 17116639
esv2734888 CNV deletion 23290073
esv2752134 CNV gain 17911159
nsv1018841 CNV gain 25217958
nsv1030604 CNV gain 25217958
nsv607972 CNV loss 21841781
nsv607973 CNV loss 21841781
nsv607974 CNV loss 21841781
nsv824241 CNV gain 20364138
nsv831075 CNV loss 17160897

Variation tolerance for VGF Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for VGF Gene

Human Gene Mutation Database (HGMD)
VGF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGF Gene

Disorders for VGF Gene

MalaCards: The human disease database

(3) MalaCards diseases for VGF Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary large cell neuroendocrine carcinoma
  • large cell lung neuroendocrine carcinoma
pheochromocytoma
  • pheochromocytoma, susceptibility to
asperger syndrome
  • asperger disorder
- elite association - COSMIC cancer census association via MalaCards
Search VGF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for VGF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with VGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VGF Gene

Publications for VGF Gene

  1. Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF. (PMID: 9344675) Canu N … Levi A (Genomics 1997) 2 3 4 22 58
  2. The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment. (PMID: 20164831) Cattaneo A … Gennarelli M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 22 58
  3. Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF. (PMID: 19194657) Toshinai K … Nakazato M (Cellular and molecular life sciences : CMLS 2009) 4 22 58
  4. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PMID: 19598235) Chakrabarti B … Baron-Cohen S (Autism research : official journal of the International Society for Autism Research 2009) 3 44 58
  5. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. (PMID: 17684500) Wedenoja J … Peltonen L (Molecular psychiatry 2008) 3 22 58

Products for VGF Gene

Sources for VGF Gene

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