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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VGF Gene

protein-coding   GIFtS: 51
GCID: GC07M100805

VGF Nerve Growth Factor Inducible

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
VGF Nerve Growth Factor Inducible1 2
Neuro-Endocrine Specific Protein VGF1 2
Neurosecretory Protein VGF2

External Ids:    HGNC: 126841   Entrez Gene: 74252   Ensembl: ENSG000001285647   OMIM: 6021865   UniProtKB: O152403   

Export aliases for VGF gene to outside databases

Previous GC identifers: GC07M099289 GC07M100352 GC07M100365 GC07M100401 GC07M100592 GC07M095398


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VGF Gene:
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth
factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and
the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein
also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
(provided by RefSeq, Jul 2008)

GeneCards Summary for VGF Gene: 
VGF (VGF nerve growth factor inducible) is a protein-coding gene. Diseases associated with VGF include pulmonary large cell neuroendocrine carcinoma, and neuroendocrine carcinoma. GO annotations related to this gene include neuropeptide hormone activity and molecular_function.

UniProtKB/Swiss-Prot: VGF_HUMAN, O15240
Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of
the nervous system (By similarity)
Function: NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release
Function: Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity
against P. Pastoris




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VGF gene promoter:
         CREB   Pax-5   deltaCREB   Pax-6   HTF   Olf-1   STAT3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VGF promoter sequence
   Search SABiosciences Chromatin IP Primers for VGF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

VGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VGF gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100805:  view genomic region     (about GC identifiers)

Start:
100,805,790 bp from pter      End:
100,808,874 bp from pter
Size:
3,085 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,164,177-100,167,239     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VGF_HUMAN, O15240 (See protein sequence)
Recommended Name: Neurosecretory protein VGF precursor  
Size: 615 amino acids; 67258 Da
Subcellular location: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then
secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus
Secondary accessions: Q9UDW8

Explore the universe of human proteins at neXtProt for VGF: NX_O15240

Explore proteomics data for VGF at MOPED 

Post-translational modifications:

  • UniProtKB: Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection,
    autonomic activation, and increases in energy expenditure (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15240

  • VGF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VGF Protein Expression
    REFSEQ proteins: NP_003369.2  
    ENSEMBL proteins: 
     ENSP00000249330   ENSP00000400884  

    Human Recombinant Protein Products for VGF: 
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    OriGene Protein Over-expression Lysate for VGF
    OriGene MassSpec for VGF 
    OriGene Custom Protein Services for VGF
    GenScript Custom Purified and Recombinant Proteins Services for VGF
    Novus Biologicals VGF Protein
    Novus Biologicals VGF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VGF 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA15706611
    GO:0030133transport vesicle IEA--
    GO:0031410cytoplasmic vesicle IDA17440014

    VGF for ontologies           About GeneDecksing



    VGF Antibody Products: 
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    Abcam antibodies for VGF
    Cloud-Clone Corp. Antibodies for VGF 
    ThermoFisher Antibodies for VGF
    LSBio Antibodies in human, mouse, rat for VGF 

    Assay Products for VGF: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VGF 
    Cloud-Clone Corp. CLIAs for VGF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026128 VGF

    Graphical View of Domain Structure for InterPro Entry O15240

    ProtoNet protein and cluster: O15240


    VGF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VGF_HUMAN, O15240
    Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of
    the nervous system (By similarity)
    Function: NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release
    Function: Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity
    against P. Pastoris

         Genatlas biochemistry entry for VGF:
    neurotrophin responsive factor,70kDa,expressed in the brain,with a C terminal region encoding posttranslationaly
    processed peptides

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005184neuropeptide hormone activity IEA--
    GO:0008083growth factor activity IEA--
         
    VGF for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vgf):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     integument  mortality/aging  nervous system  reproductive system 

    VGF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Vgftm1Srjs for VGF

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VGF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VGF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VGF 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VGF
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate VGF (see all 11):
    hsa-miR-3163 hsa-miR-548p hsa-miR-3184 hsa-miR-1914* hsa-miR-3605-3p hsa-miR-548o hsa-miR-138-2* hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidVGF 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of VGF

    Clone
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    OriGene clones in human, mouse for VGF (see all 4)
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VGF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VGF

    3 Interacting proteins for VGF (O152403) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933I2D: score=2 
    APLP1P516933I2D: score=1 
    MAPK3P273613I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0002021response to dietary excess IEA--
    GO:0006091generation of precursor metabolites and energy IEA--
    GO:0009409response to cold IEA--
    GO:0019953sexual reproduction IEA--

    VGF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    VGF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VGF

    5 Novoseek inferred chemical compound relationships for VGF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 25.8 3 8395923 (1), 7476021 (1)
    cyclic amp 23.4 1 9084409 (1)
    tyrosine 16.2 4 8525617 (3), 7875312 (1)
    thymidine 14.2 2 12522439 (1), 12603984 (1)
    vegf 0 1 14645477 (1)

    Search CenterWatch for drugs/clinical trials and news about VGF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VGF gene: 
    NM_003378.3  

    Unigene Cluster for VGF:

    VGF nerve growth factor inducible
    Hs.587325  [show with all ESTs]
    Unigene Representative Sequence: BC063835
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249330(uc003uxx.4) ENST00000445482

    miRNA
    Products:
         
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate VGF (see all 11):
    hsa-miR-3163 hsa-miR-548p hsa-miR-3184 hsa-miR-1914* hsa-miR-3605-3p hsa-miR-548o hsa-miR-138-2* hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidVGF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VGF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VGF
    Clone
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    OriGene ORF clones in mouse, rat for VGF
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    GenScript: all cDNA clones in your preferred vector: VGF (NM_003378)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VGF
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    Primer
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    OriGene qPCR primer pairs and template standards for VGF
    OriGene qSTAR qPCR primer pairs in human, mouse for VGF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VGF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VGF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VGF

    Additional mRNA sequence: 

    AK225839.1 BC006217.2 BC036537.1 BC044212.1 BC063835.1 

    5 DOTS entries:

    DT.91892495  DT.97794502  DT.101984471  DT.300806  DT.75102021 

    24/86 AceView cDNA sequences (see all 86):

    BQ639541 BM911486 BC063835 BQ637569 BM142297 AW245132 BM726762 BM263198 
    CK820236 CK904961 BM052867 BU166517 BM068821 BC006217 AW207250 CD108874 
    BM718178 CK904657 BC036537 BC044212 BU784525 BI963104 BM126861 BE855486 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VGF expression in normal human tissues (normalized intensities)      VGF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCCCGGCC
    VGF Expression
    About this image


    VGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Skeletal Muscle Myoblast (HSkMM)   
     
     Melanocytes (Integumentary System)
             Human EpiDermal Melanocytes (HEM)   
     
     Kidney (Urinary System)
             Human Renal Proximal Tubular Epithelial Cells (HRPTEpiC)   
     
     Bone (Muscoskeletal System)
             Human Vertebral Mesenchymal Stem Cells (HVMSC)   
     
     Inner Cell Mass (Early Embryonic Tissues)
             CyT49

    See VGF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VGF

    SOURCE GeneReport for Unigene cluster: Hs.587325

    UniProtKB/Swiss-Prot: VGF_HUMAN, O15240
    Tissue specificity: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine
    cells

        SABiosciences Expression via Pathway-Focused PCR Array including VGF: 
              Neurotrophins & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for VGF gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vgf1 , 5 VGF nerve growth factor inducible1, 5 85.48(n)1
    86.3(a)1
      5 (76.13 cM)5
    3816771  NM_001039385.11  NP_001034474.11 
     1370302955 
    chicken
    (Gallus gallus)
    Aves VGF6
    VGF nerve growth factor inducible
    26(a)
    1 ↔ 1
    AADN03015652.1(21-1214)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-175g6.21 si:dkey-175g6.2 46.77(n)
    34.88(a)
      793455  XM_001333183.1  XP_001333219.1 
    rice
    (Oryza sativa)
    Liliopsida Os.467622 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.39(n)    AK120364.1 


    ENSEMBL Gene Tree for VGF (if available)
    TreeFam Gene Tree for VGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/89 SNPs in VGF are shown (see all 89)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162829121,2
    C,F--100805369(+) GTGAAC/TACAGG 1 -- ds50011Minor allele frequency- T:0.07WA 118
    rs1447682691,2
    --100805451(+) ACCTTA/CTGCGG 1 -- ds50010--------
    rs107558661,2
    C,F,A,H--100805460(+) GGGTCA/GCCTTT 1 -- ds500128Minor allele frequency- G:0.40NS EA NA WA CSA 2777
    rs109533251,2
    C,F,A,H--100805508(+) AATTGG/ACTCTT 1 -- ds500129Minor allele frequency- A:0.44NS EA NA WA CSA 2957
    rs1876842011,2
    --100805520(+) TATTGC/GATTCC 1 -- ds50010--------
    rs1457034721,2
    C--100805598(+) AATTTC/TGGGTT 1 -- ds50010--------
    rs21078041,2
    C,H--100805671(+) CCCCTC/TGCCTT 1 -- ds500111Minor allele frequency- T:0.01NA WA CSA EA 372
    rs1140632001,2
    C,F--100805678(+) CCTTAA/GTTTGG 1 -- ds50010--------
    rs99186351,2
    C,F,A,H--100805704(+) GGAGAT/CGGGGA 1 -- ds500127Minor allele frequency- C:0.40NS EA NA WA CSA 2755
    rs1846555711,2
    --100805921(+) GGCCCA/GAAGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for VGF (100805790 - 100808874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for VGF:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2422376CNV Duplication17116639
    dgv7409n71CNV Loss21882294
    nsv831075CNV Loss17160897
    esv2752134CNV Gain17911159
    nsv824241CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing VGF
    DNA2.0 Custom Variant and Variant Library Synthesis for VGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602186    OMIM disorders: --

    14 diseases for VGF:    About MalaCards
    pulmonary large cell neuroendocrine carcinoma    neuroendocrine carcinoma    vaccinia    pheochromocytoma
    lateral sclerosis    amyotrophic lateral sclerosis    neuroblastoma    schizophrenia
    lung cancer    alzheimer's disease    thyroiditis    neuronitis
    breast cancer    pancreatitis


    VGF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for VGF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 38.8 3 9478934 (1), 1469059 (1), 9084409 (1)
    tumors 0 2 18328103 (1)

    Genetic Association Database (GAD): VGF
    Human Genome Epidemiology (HuGE) Navigator: VGF (3 documents)

    Export disorders for VGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VGF gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with VGF)
        Utopia: connect your pdf to the dynamic
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    1. Cloning, structural organization analysis and chromosomal assignment of the human gene for neurosecretory protein VGF. (PubMed id 9344675)1, 2, 3, 9 Canu N.... Levi A. (1997)
    2. Genes related to sex steroids, neural growth, and soc ial-emotional behavior are associated with autistic traits, empathy, and Asperg er syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (2009)
    3. The expression of VGF is reduced in leukocytes of dep ressed patients and it is restored by effective antidepressant treatment. (PubMed id 20164831)1, 9 Cattaneo A....Gennarelli M. (2010)
    4. Molecular cloning and characterization of the human VGF promoter region. (PubMed id 9084409)1, 9 Canu N....Levi A. (1997)
    5. Neuroendocrine regulatory peptide-1 and -2: novel bio active peptides processed from VGF. (PubMed id 19194657)2, 9 Toshinai K. and Nakazato M. (2009)
    6. Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and tyrosine hydroxylase. (PubMed id 10381005)1, 9 Nagasaki K....Yamaguchi K. (1999)
    7. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. (PubMed id 17684500)1, 9 Wedenoja J....Peltonen L. (2008)
    8. Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry. (PubMed id 23250050)2 Sasaki K.... Minamino N. (2012)
    9. NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius, of type-II diab etic patients. (PubMed id 22808091)1 Saderi N....Buijs R.M. (2012)
    10. VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers. (PubMed id 21621608)1 Ferri G.L....Cocco C. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7425 HGNC: 12684 AceView: VGF Ensembl:ENSG00000128564 euGenes: HUgn7425
    ECgene: VGF H-InvDB: VGF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for VGF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for VGF gene:
    Search GeneIP for patents involving VGF

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