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Aliases for VGF Gene

Aliases for VGF Gene

  • VGF Nerve Growth Factor Inducible 2 3
  • Neuro-Endocrine Specific Protein VGF 2 3
  • SgVII 3
  • SCG7 3

External Ids for VGF Gene

Previous GeneCards Identifiers for VGF Gene

  • GC07M099289
  • GC07M100352
  • GC07M100365
  • GC07M100401
  • GC07M100592
  • GC07M100805
  • GC07M095398

Summaries for VGF Gene

Entrez Gene Summary for VGF Gene

  • This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for VGF Gene

VGF (VGF Nerve Growth Factor Inducible) is a Protein Coding gene. Diseases associated with VGF include pulmonary large cell neuroendocrine carcinoma and pheochromocytoma. GO annotations related to this gene include growth factor activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for VGF Gene

  • May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.

  • NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.

  • Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGF Gene

Genomics for VGF Gene

Regulatory Elements for VGF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VGF Gene

Chromosome:
7
Start:
101,162,509 bp from pter
End:
101,169,935 bp from pter
Size:
7,427 bases
Orientation:
Minus strand

Genomic View for VGF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGF Gene

Proteins for VGF Gene

  • Protein details for VGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15240-VGF_HUMAN
    Recommended name:
    Neurosecretory protein VGF
    Protein Accession:
    O15240
    Secondary Accessions:
    • Q9UDW8

    Protein attributes for VGF Gene

    Size:
    615 amino acids
    Molecular mass:
    67258 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VGF Gene

Proteomics data for VGF Gene at MOPED

Post-translational modifications for VGF Gene

  • Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
  • Glycosylation at Thr 189, Ser 252, Ser 253, Thr 256, and Thr 554
  • Modification sites at PhosphoSitePlus

Other Protein References for VGF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for VGF Gene

Domains & Families for VGF Gene

Gene Families for VGF Gene

Protein Domains for VGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VGF: view

No data available for UniProtKB/Swiss-Prot for VGF Gene

Function for VGF Gene

Molecular function for VGF Gene

GENATLAS Biochemistry:
neurotrophin responsive factor,70kDa,expressed in the brain,with a C terminal region encoding posttranslationaly processed peptides
UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.
UniProtKB/Swiss-Prot Function:
NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.
UniProtKB/Swiss-Prot Function:
Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.

Gene Ontology (GO) - Molecular Function for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005179 hormone activity IBA --
GO:0005184 neuropeptide hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with VGF: view
genes like me logo Genes that share phenotypes with VGF: view

Animal Models for VGF Gene

MGI Knock Outs for VGF:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for VGF Gene

Localization for VGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGF Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VGF Gene COMPARTMENTS Subcellular localization image for VGF gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 15706611
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IDA 17440014
genes like me logo Genes that share ontologies with VGF: view

Pathways & Interactions for VGF Gene

SuperPathways for VGF Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Neurotrophins & Receptors in human,mouse,rat

Interacting Proteins for VGF Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000249330%0d%0a9606.ENSP00000316578%0d%0a9606.ENSP00000356480%0d%0a9606.ENSP00000355865%0d%0a
Selected Interacting proteins: O15240-VGF_HUMAN ENSP00000249330 for VGF Gene via I2D STRING

Gene Ontology (GO) - Biological Process for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0002021 response to dietary excess IEA --
GO:0006091 generation of precursor metabolites and energy IEA --
GO:0009409 response to cold IEA --
GO:0019953 sexual reproduction IEA --
genes like me logo Genes that share ontologies with VGF: view

No data available for Pathways by source and SIGNOR curated interactions for VGF Gene

Drugs & Compounds for VGF Gene

(4) Drugs for VGF Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Forskolin Experimental Pharma 0
thymidine Experimental Pharma 0
tyrosine Nutra 547

(1) Additional Compounds for VGF Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
VEGF
genes like me logo Genes that share compounds with VGF: view

Transcripts for VGF Gene

Unigene Clusters for VGF Gene

VGF nerve growth factor inducible:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VGF Gene

No ASD Table

Relevant External Links for VGF Gene

GeneLoc Exon Structure for
VGF
ECgene alternative splicing isoforms for
VGF

Expression for VGF Gene

mRNA expression in normal human tissues for VGF Gene

mRNA differential expression in normal tissues according to GTEx for VGF Gene

This gene is overexpressed in Brain - Hypothalamus (x14.2), Pituitary (x7.9), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Cortex (x4.7), and Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for VGF Gene

This gene is overexpressed in Cerebrospinal fluid (31.0) and Islet of Langerhans (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VGF Gene



SOURCE GeneReport for Unigene cluster for VGF Gene Hs.587325

mRNA Expression by UniProt/SwissProt for VGF Gene

O15240-VGF_HUMAN
Tissue specificity: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
genes like me logo Genes that share expression patterns with VGF: view

Protein tissue co-expression partners for VGF Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for VGF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VGF Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia VGF 35
  • 90.41 (n)
  • 91.71 (a)
VGF 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vgf 35
  • 84.67 (n)
  • 84.99 (a)
Vgf 16
Vgf 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VGF 35
  • 99.51 (n)
  • 99.19 (a)
VGF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vgf 35
  • 85.21 (n)
  • 85.32 (a)
cow
(Bos Taurus)
Mammalia VGF 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VGF 36
  • 63 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.46762 35
Species with no ortholog for VGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VGF Gene

ENSEMBL:
Gene Tree for VGF (if available)
TreeFam:
Gene Tree for VGF (if available)

Paralogs for VGF Gene

No data available for Paralogs for VGF Gene

Variants for VGF Gene

Sequence variations from dbSNP and Humsavar for VGF Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1058351 -- 101,162,715(-) TCCCT(C/T)TGGGG utr-variant-3-prime
rs1064431 -- 101,163,401(-) CGGAA(C/G)CGAAA missense, reference
rs1476627 -- 101,163,784(+) CGCCG(C/T)CTCCT missense, reference
rs2107804 -- 101,162,390(+) CCCCT(C/T)GCCTT downstream-variant-500B
rs2898568 -- 101,167,702(+) AAGAC(A/G)GGCAC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VGF Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
dgv7409n71 CNV Loss 21882294
esv2752134 CNV Gain 17911159
nsv824241 CNV Gain 20364138

Variation tolerance for VGF Gene

Residual Variation Intolerance Score: 26.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VGF Gene

HapMap Linkage Disequilibrium report
VGF
Human Gene Mutation Database (HGMD)
VGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGF Gene

Disorders for VGF Gene

MalaCards: The human disease database

(2) MalaCards diseases for VGF Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary large cell neuroendocrine carcinoma
  • large cell lung neuroendocrine carcinoma
pheochromocytoma
  • pheochromocytoma, modifier of
- elite association
Search VGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for VGF

Genetic Association Database (GAD)
VGF
Human Genome Epidemiology (HuGE) Navigator
VGF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VGF
genes like me logo Genes that share disorders with VGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VGF Gene

Publications for VGF Gene

  1. Cloning, structural organization analysis and chromosomal assignment of the human gene for neurosecretory protein VGF. (PMID: 9344675) Canu N. … Levi A. (Genomics 1997) 2 23 67
  2. The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment. (PMID: 20164831) Cattaneo A. … Gennarelli M. (Neuropsychopharmacology 2010) 23 67
  3. Target identification for CNS diseases by transcriptional profiling. (PMID: 18923405) Altar C.A. … Ginsberg S.D. (Neuropsychopharmacology 2009) 23 67
  4. Neuropeptides in depression: role of VGF. (PMID: 18983874) Thakker-Varia S. … Alder J. (Behav. Brain Res. 2009) 23 67
  5. Photoperiod and acute energy deficits interact on components of the thyroid hormone system in hypothalamic tanycytes of the Siberian hamster. (PMID: 19297543) Herwig A. … Barrett P. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009) 23 67

Products for VGF Gene

Sources for VGF Gene

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