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Aliases for VGF Gene

Aliases for VGF Gene

  • VGF Nerve Growth Factor Inducible 2 3 5
  • Neuro-Endocrine Specific Protein VGF 2 3
  • Neurosecretory Protein VGF 3
  • SgVII 3
  • SCG7 3

External Ids for VGF Gene

Previous GeneCards Identifiers for VGF Gene

  • GC07M099289
  • GC07M100352
  • GC07M100365
  • GC07M100401
  • GC07M100592
  • GC07M100805
  • GC07M095398

Summaries for VGF Gene

Entrez Gene Summary for VGF Gene

  • This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for VGF Gene

VGF (VGF Nerve Growth Factor Inducible) is a Protein Coding gene. Diseases associated with VGF include Pulmonary Large Cell Neuroendocrine Carcinoma and Pheochromocytoma. GO annotations related to this gene include growth factor activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for VGF Gene

  • May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.

  • NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.

  • Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VGF Gene

Genomics for VGF Gene

Regulatory Elements for VGF Gene

Enhancers for VGF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G101098 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +67.9 67914 6.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 MEF2D SSRP1 GLIS1 RCOR2 NBN SERPINE1 VGF NAT16 MUC12 MBLAC1 MUC3A MUC17 TRIM56 PCOLCE-AS1 LOC102724094
GH07G101192 1.5 Ensembl ENCODE dbSUPER 12.7 -22.7 -22652 1.2 HDGF ATF1 ARNT AGO1 WRNIP1 ARID4B FEZF1 ZNF48 YY1 ZNF143 AP1S1 ZNHIT1 PLOD3 VGF NAT16
GH07G101093 1.4 Ensembl ENCODE dbSUPER 11.8 +75.5 75532 2.4 ATF1 CBX3 TBL1XR1 ARID4B SIN3A ZNF2 ZNF48 RAD21 TCF12 ZNF121 VGF NAT16 TRIP6 LOC102724094 GC07P101095 SERPINE1
GH07G101307 1.5 FANTOM5 ENCODE dbSUPER 10.7 -138.6 -138619 1.7 PKNOX1 MLX CREB3L1 AGO1 ARID4B E2F7 SIN3A DMAP1 ZNF2 KLF7 LOC101927746 COL26A1 NAT16 VGF PIR32353
GH07G101107 1.4 Ensembl ENCODE dbSUPER 11.3 +60.9 60872 2.5 ELF3 PKNOX1 TBL1XR1 ARID4B ZNF48 RARA EGR1 SCRT2 FOS RELB VGF NAT16 MUC12 MUC3A MUC17 PCOLCE-AS1 ACHE AP1S1 LOC102724094 GC07P101095
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VGF on UCSC Golden Path with GeneCards custom track

Genomic Location for VGF Gene

Chromosome:
7
Start:
101,162,509 bp from pter
End:
101,169,935 bp from pter
Size:
7,427 bases
Orientation:
Minus strand

Genomic View for VGF Gene

Genes around VGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VGF Gene

Proteins for VGF Gene

  • Protein details for VGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15240-VGF_HUMAN
    Recommended name:
    Neurosecretory protein VGF
    Protein Accession:
    O15240
    Secondary Accessions:
    • Q9UDW8

    Protein attributes for VGF Gene

    Size:
    615 amino acids
    Molecular mass:
    67258 Da
    Quaternary structure:
    No Data Available

neXtProt entry for VGF Gene

Post-translational modifications for VGF Gene

  • Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
  • Glycosylation at posLast=189189, posLast=252252, Ser253, posLast=256256, and Thr554
  • Modification sites at PhosphoSitePlus

Other Protein References for VGF Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for VGF

No data available for DME Specific Peptides for VGF Gene

Domains & Families for VGF Gene

Gene Families for VGF Gene

Protein Domains for VGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VGF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with VGF: view

No data available for UniProtKB/Swiss-Prot for VGF Gene

Function for VGF Gene

Molecular function for VGF Gene

GENATLAS Biochemistry:
neurotrophin responsive factor,70kDa,expressed in the brain,with a C terminal region encoding posttranslationaly processed peptides
UniProtKB/Swiss-Prot Function:
May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.
UniProtKB/Swiss-Prot Function:
NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.
UniProtKB/Swiss-Prot Function:
Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.

Gene Ontology (GO) - Molecular Function for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005179 hormone activity IBA --
GO:0005184 neuropeptide hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with VGF: view
genes like me logo Genes that share phenotypes with VGF: view

Animal Models for VGF Gene

MGI Knock Outs for VGF:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VGF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VGF Gene

Localization for VGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for VGF Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VGF gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15706611
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IDA,IEA 17440014
genes like me logo Genes that share ontologies with VGF: view

Pathways & Interactions for VGF Gene

No Data Available

Interacting Proteins for VGF Gene

Gene Ontology (GO) - Biological Process for VGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0002021 response to dietary excess IEA --
GO:0006091 generation of precursor metabolites and energy IEA --
GO:0009409 response to cold IEA --
GO:0019953 sexual reproduction IEA --
genes like me logo Genes that share ontologies with VGF: view

No data available for Pathways by source and SIGNOR curated interactions for VGF Gene

Drugs & Compounds for VGF Gene

(5) Drugs for VGF Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TLQP 21 Pharma VGF-derived peptide 0

(1) Additional Compounds for VGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for VGF Gene

Compound Action Cas Number
TLQP 21 VGF-derived peptide 869988-94-3
genes like me logo Genes that share compounds with VGF: view

Drug Products

Transcripts for VGF Gene

Unigene Clusters for VGF Gene

VGF nerve growth factor inducible:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for VGF

Alternative Splicing Database (ASD) splice patterns (SP) for VGF Gene

No ASD Table

Relevant External Links for VGF Gene

GeneLoc Exon Structure for
VGF
ECgene alternative splicing isoforms for
VGF

Expression for VGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for VGF Gene

mRNA differential expression in normal tissues according to GTEx for VGF Gene

This gene is overexpressed in Brain - Hypothalamus (x14.2), Pituitary (x7.9), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Cortex (x4.7), and Brain - Frontal Cortex (BA9) (x4.6).

Protein differential expression in normal tissues from HIPED for VGF Gene

This gene is overexpressed in Cerebrospinal fluid (31.0) and Islet of Langerhans (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VGF Gene



Protein tissue co-expression partners for VGF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VGF Gene:

VGF

SOURCE GeneReport for Unigene cluster for VGF Gene:

Hs.587325

mRNA Expression by UniProt/SwissProt for VGF Gene:

O15240-VGF_HUMAN
Tissue specificity: Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.

Evidence on tissue expression from TISSUES for VGF Gene

  • Nervous system(4.7)
  • Pancreas(3.1)
  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with VGF: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for VGF Gene

Orthologs for VGF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for VGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VGF 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia VGF 34 35
  • 90.41 (n)
cow
(Bos Taurus)
Mammalia VGF 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vgf 34
  • 85.21 (n)
mouse
(Mus musculus)
Mammalia Vgf 34 16 35
  • 84.67 (n)
oppossum
(Monodelphis domestica)
Mammalia VGF 35
  • 63 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.46762 34
Species where no ortholog for VGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for VGF Gene

ENSEMBL:
Gene Tree for VGF (if available)
TreeFam:
Gene Tree for VGF (if available)

Paralogs for VGF Gene

No data available for Paralogs for VGF Gene

Variants for VGF Gene

Sequence variations from dbSNP and Humsavar for VGF Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001211664 -- 101,166,014(+) GCGTC(C/T)GACTG intron-variant, upstream-variant-2KB
rs1001503187 -- 101,163,518(+) TCGTC(C/G)TCCTC reference, missense
rs1001673007 -- 101,169,861(+) ACATG(C/T)ACAGA intron-variant
rs1002013828 -- 101,171,210(+) GCCCG(G/T)CTCGG upstream-variant-2KB, utr-variant-3-prime
rs1002182315 -- 101,164,973(+) TGATC(C/T)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VGF Gene

Variant ID Type Subtype PubMed ID
dgv11534n54 CNV loss 21841781
esv2422376 CNV duplication 17116639
esv2734888 CNV deletion 23290073
esv2752134 CNV gain 17911159
nsv1018841 CNV gain 25217958
nsv1030604 CNV gain 25217958
nsv607972 CNV loss 21841781
nsv607973 CNV loss 21841781
nsv607974 CNV loss 21841781
nsv824241 CNV gain 20364138
nsv831075 CNV loss 17160897

Variation tolerance for VGF Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VGF Gene

Human Gene Mutation Database (HGMD)
VGF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
VGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VGF Gene

Disorders for VGF Gene

MalaCards: The human disease database

(2) MalaCards diseases for VGF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary large cell neuroendocrine carcinoma
  • large cell lung neuroendocrine carcinoma
pheochromocytoma
  • pheochromocytoma, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search VGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for VGF

Genetic Association Database (GAD)
VGF
Human Genome Epidemiology (HuGE) Navigator
VGF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VGF
genes like me logo Genes that share disorders with VGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VGF Gene

Publications for VGF Gene

  1. Cloning, structural organization analysis and chromosomal assignment of the human gene for neurosecretory protein VGF. (PMID: 9344675) Canu N. … Levi A. (Genomics 1997) 2 3 4 22 64
  2. The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment. (PMID: 20164831) Cattaneo A. … Gennarelli M. (Neuropsychopharmacology 2010) 3 22 64
  3. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PMID: 19598235) Chakrabarti B. … Baron-Cohen S. (Autism Res 2009) 3 46 64
  4. Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF. (PMID: 19194657) Toshinai K. … Nakazato M. (Cell. Mol. Life Sci. 2009) 4 22 64
  5. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. (PMID: 17684500) Wedenoja J. … Peltonen L. (Mol. Psychiatry 2008) 3 22 64

Products for VGF Gene

Sources for VGF Gene

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