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Aliases & Descriptions for VGF
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| VGF nerve growth factor inducible 2 | | neuro-endocrine specific protein VGF 2 | | neurosecretory protein VGF 2 |
|
| | Search outside databases for aliases for VGF genePrevious GC identifers: GC07M099289 GC07M100352 GC07M100365 GC07M100401 |
Summaries for VGF(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for VGF: This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq] UniProtKB/Swiss-Prot: VGF_HUMAN, O15240Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system (By similarity) |
Genomic Location for VGF
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VGF gene 
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22VGF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M100592:
(about GC identifiers)
Start:
|
100,592,517 bp from pter |
End:
|
100,595,594 bp from pter |
Size:
|
3,078 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 100,164,184-100,167,239 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079596.2
| Proteins for VGF
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VGF_HUMAN, O15240 (See
protein sequence)Recommended Name: Neurosecretory protein VGF precursor Size: 615 amino acids; 67258 Da
Subcellular location: Secreted (By similarity). Cytoplasmic vesicle, secretory vesicle (By similarity). Note=Stored in secretory vesicles and then secreted (By similarity)
Secondary accessions: Q9UDW8REFSEQ proteins: NP_003369.2
ENSEMBL proteins: ENSP00000249330
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VGF: Assays for VGF: | Protein
Domains/ Families for VGF(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O15240 | Gene Function for VGF
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003378
Applied Biosystems Silencer® siRNAs for VGF
Sigma-Aldrich siRNA for VGF  Sigma-Aldrich shRNA for VGF  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003378                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003378                                  untagged cDNA clone in CMV expression vector: NM_003378 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003378
UniProtKB/Swiss-Prot: VGF_HUMAN, O15240Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system (By similarity)Genatlas biochemistry entry for VGF:neurotrophin responsive factor,70kDa,expressed in the brain,with a C terminal region encoding posttranslationaly processed peptides8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Vgf):
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005184 | neuropeptide hormone activity |
IEA | -- | | GO:0008083 | growth factor activity |
IEA | -- | About this table | Pathways & Interactions for VGF
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VGF 
5/15 Interacting proteins for VGF (ENSP000002493303) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001541 | ovarian follicle development |
IEA | -- | | GO:0002021 | response to dietary excess |
IEA | -- | | GO:0006091 | generation of precursor metabolites and energy |
IEA | -- | | GO:0009409 | response to cold |
IEA | -- | | GO:0019953 | sexual reproduction |
IEA | -- | About this table
|
Drugs & Compounds for VGF(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VGF 4 Novoseek chemical compound relationships for VGF gene
About this table
|
Transcripts for VGF(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003378
Sigma-Aldrich siRNA for VGF  Sigma-Aldrich shRNA for VGF  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003378 REFSEQ mRNAs for VGF gene: NM_003378.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003378               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003378                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003378                                  untagged cDNA clone in CMV expression vector: NM_003378  Additional cDNA sequence: AK225839.1 BC006217.2 BC036537.1 BC044212.1 BC063835.1 5 DOTS entries: DT.91892495 DT.97794502 DT.101984471 DT.300806 DT.75102021 24/86 AceView cDNA sequences (see all 86
):CK820236 CK904657 BM142488 BQ637569 BQ639541 NM_003378 BC063835 BU166517 BM126861 BM911486 BC006217 BM068821 BM263198 BM718178 BG236881 CD108874 BM726762 BE855486 BC044212 AW245132 BM142297 BI963104 CK904961 BU784525
highest scoring ESTs for VGF:BC036537 BC063835 BI712777 AA224159 AI811072 AI951596 AL523909 AW248251 BI552988 BM023247 Unigene Cluster for VGF: VGF nerve growth factor inducible Hs.718797 [show with all ESTs]Unigene Representative Sequence: BC063835
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000249330
|
Expression for VGF
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VGF expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VGF
1 / 2 / 3 4 probe-sets matching VGF gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CGCCCCGGCC
SOURCE GeneReport for Unigene cluster: Hs.718797
Expression variation in blood from EXPOLDB for VGF UniProtKB/Swiss-Prot: VGF_HUMAN, O15240Tissue specificity: Expressed in brain |
Orthologs for VGF
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VGF gene from 5 species
About this table Species with no ortholog for VGF
ENSEMBL Gene Tree for VGF | Paralogs for VGF(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for VGF(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VGF (up to first 250kb)
|
Disorders & Mutations for VGF
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602186
2 Novoseek disease relationships for VGF gene
About this table
Human Genome Epidemiology Navigator: VGF (2 documents)
|
Medical News for VGF(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VGF (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/61 PubMed articles for VGF gene (see all 61
):- Cloning, structural organization analysis and chromosomal assignment of the human gene for neurosecretory protein VGF. (PubMed id 9344675)1, 2, 3, 4 Canu N.... Levi A. (1997)
- Molecular cloning and characterization of the human VGF promoter region. (PubMed id 9084409)1, 3 Canu N....Levi A. (1997)
- Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and tyrosine hydroxylase. (PubMed id 10381005)1, 3 Nagasaki K....Yamaguchi K. (1999)
- Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. (PubMed id 17684500)1, 3 Wedenoja J....Peltonen L. (2008)
- Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis. (PubMed id 18432310)3 Zhao Z....Pasinetti G.M. (2008)
- Peptide products of the neurotrophin-inducible gene vgf are produced in human neuroendocrine cells from early development and increase in hyperplasia and neoplasia. (PubMed id 17440014)3 Rindi G....Ferri G.L. (2007)
- Identification of potential CSF biomarkers in ALS. (PubMed id 16481598)3 Pasinetti G.M....Ho L. (2006)
- Human cerebrospinal fluid peptidomics. (PubMed id 15706611)3 Yuan X. and Desiderio D.M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)4 Hillier L.W.... Wilson R.K. (2003)
|
Search for VGF
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VGF
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VGF
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VGF(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VGF(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VGF:

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