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Aliases & Descriptions for VEZT
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZP761C241 1 | | DKFZp761C241 2 | | VEZATIN 2 |
| | | Descriptions |
|---|
| transmembrane protein vezatin 2 | | vezatin, adherens junctions transmembrane protein 2 |
|
| | Search outside databases for aliases for VEZT gene |
Summaries for VEZT(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating to myosin VIIa recruitment to the entry siteGene Wiki entry for VEZT |
Genomic Location for VEZT
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VEZT gene 
Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q22VEZT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P094115:
(about GC identifiers)
Start:
|
94,135,653 bp from pter |
End:
|
94,220,697 bp from pter |
Size:
|
85,045 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_019546.15
| Proteins for VEZT
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0 (See
protein sequence)Recommended Name: Vezatin Size: 779 amino acids; 88665 Da
Subunit: Interacts with myosin VIIa and the cadherin-catenins complex
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus. Acrosome (By similarity)
Secondary accessions: Q6P1Q3 Q9H2F4 Q9H2U5 Q9NT70 Q9NVW0 Q9UF91Alternative splicing: 6 isoforms: Q9HBM0-1 Q9HBM0-2 Q9HBM0-3 Q9HBM0-4 Q9HBM0-5 Q9HBM0-6 (Experimental confirmation may be lacking for some isoforms)Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060069.3
ENSEMBL proteins: ENSP00000349319 ENSP00000380894 ENSP00000261219 ENSP00000380898
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for VEZT: Assays for VEZT: | Protein
Domains/ Families for VEZT(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9HBM0 UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0Similarity: Belongs to the vezatin family | Gene Function for VEZT
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017599
Applied Biosystems Silencer® siRNAs for VEZT
Sigma-Aldrich siRNA for VEZT  Sigma-Aldrich shRNA for VEZT  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017599                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017599                                  untagged cDNA clones in CMV expression vector (see all 2): NM_017599 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_017599
UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating to myosin VIIa recruitment to the entry site4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Vezt):
| Pathways & Interactions for VEZT
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for VEZT 
4 Interacting proteins for VEZT (ENSP000002612193) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for VEZT(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VEZT
|
Transcripts for VEZT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017599
Sigma-Aldrich siRNA for VEZT  Sigma-Aldrich shRNA for VEZT  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_017599 REFSEQ mRNAs for VEZT gene: NM_017599.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_017599               OriGene GFP tagged cDNA clone in CMV expression vector: NM_017599                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017599                                  untagged cDNA clones in CMV expression vector (see all 2): NM_017599  Additional cDNA sequence: AF216644.1 AF225417.1 AF277625.1 AK001338.1 AK225303.1 AK225356.1 AK307649.1 AK307864.1 AK309943.1 AL133113.1 BC014443.1 BC028597.1 BC040845.1 BC064939.1 CR620366.1 24/30 DOTS entries (see all 30
): DT.443820 DT.100765984 DT.100801543 DT.101976297 DT.86842133 DT.101976753 DT.97843430 DT.75195511 DT.100844504 DT.121163603 DT.95293181 DT.452357 DT.100796102 DT.100796103 DT.121163521 DT.121163613 DT.121163469 DT.121163726 DT.40306476 DT.91750036 DT.97808641 DT.100796098 DT.40193626 DT.91702097 24/278 AceView cDNA sequences (see all 278
):BM069559 BU732896 BX417059 AI949818 AI800851 AI627614 BI488964 BP356051 AW007647 AA256817 BX345173 BQ231343 BQ430470 H96404 BX398166 BM835317 AI803510 AL137497 BX425167 AA760985 AI337288 AA282125 AA227557 BG620964
highest scoring ESTs for VEZT:AI805297 AA001856 AA054279 AA056251 AA227557 AA282124 AA282125 AA424201 AA446752 AA478490 Unigene Cluster for VEZT: Vezatin, adherens junctions transmembrane protein Hs.24135 [show with all ESTs]Unigene Representative Sequence: NM_017599
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for VEZT (see all 16
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | |
| SP1: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   |
| ExUns: | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | · | 18d | |
| SP1: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VEZT
4 Ensembl transcripts including schematic representations: ENST00000356859
ENST00000397792
ENST00000261219
ENST00000397796
|
Expression for VEZT
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VEZT expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VEZT
1 / 2 / 3 8 probe-sets matching VEZT gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CAGGAACAGA
SOURCE GeneReport for Unigene cluster: Hs.24135
|
Orthologs for VEZT
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VEZT gene from 5/9 species (see all 9
)
About this table Species with no ortholog for VEZT
ENSEMBL Gene Tree for VEZT | Paralogs for VEZT(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for VEZT(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VEZT (up to first 250kb)
|
Disorders & Mutations for VEZT
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for VEZT(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VEZT (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for VEZT gene (see all 13
):- Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. (PubMed id 11080149)1, 2, 3, 4 Kuessel-Andermann P.... Petit C. (2000)
- Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. (PubMed id 16199027)2, 3 Hyenne V....Simmler M.C. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells. (PubMed id 15090598)1, 4 Sousa S....Cossart P. (2004)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)4 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Plasma membrane components of adherens junctions (Review). (PubMed id 12126233)3 Blaschuk O.W. and Rowlands T.M. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for VEZT
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VEZT
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VEZT
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VEZT(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VEZT(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VEZT:

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| | Recombinant Proteins (VEZT) | | Antibodies (VEZT) |
| | | Search Tocris compounds for VEZT |
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Incremental update: 13 Oct 2009
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