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VEZT Gene

protein-coding   GIFtS: 49

GC12P094115
vezatin, adherens junctions transmembrane protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZP761C241 1
DKFZp761C241 2
VEZATIN 2
Descriptions
transmembrane protein vezatin 2
vezatin, adherens junctions transmembrane protein 2
External Ids
HGNC: 182581
Entrez Gene: 555912
UniProtKB: Q9HBM03
Ensembl: ENSG000000282037
Search outside databases for aliases for VEZT gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0
Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in
adult life. In case of Listeria infection, promotes bacterial internalization by participating to
myosin VIIa recruitment to the entry site

Gene Wiki entry for VEZT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VEZT gene  

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q22

VEZT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P094115:     (about GC identifiers)

Start:
94,135,653 bp from pter
End:
94,220,697 bp from pter
Size:
85,045 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000012.10  NT_019546.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0 (See protein sequence)
Recommended Name: Vezatin  
Size: 779 amino acids; 88665 Da
Subunit: Interacts with myosin VIIa and the cadherin-catenins complex
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction.
Nucleus. Acrosome (By similarity)
Secondary accessions: Q6P1Q3 Q9H2F4 Q9H2U5 Q9NT70 Q9NVW0 Q9UF91
Alternative splicing: 6 isoforms:  Q9HBM0-1   Q9HBM0-2   Q9HBM0-3   Q9HBM0-4   Q9HBM0-5   Q9HBM0-6   (Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_060069.3  

    ENSEMBL proteins: 
    ENSP00000349319 ENSP00000380894 ENSP00000261219 ENSP00000380898 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (VEZT)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669 acrosome IEA--
    GO:0005634 nucleus IEA--
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    GO:0030054 cell junction IEA--
    About this table

    Antibodies for VEZT: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for VEZT
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (VEZT), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibody for VEZT

    Assays for VEZT: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9HBM0

    UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0
    Similarity: Belongs to the vezatin family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VEZT)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017599

                  Applied Biosystems Silencer® siRNAs for VEZT

                  Sigma-Aldrich siRNA for VEZT  
                         Sigma-Aldrich shRNA for VEZT  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for VEZT
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017599
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017599
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_017599 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017599

    UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0
    Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in
    adult life. In case of Listeria infection, promotes bacterial internalization by participating to
    myosin VIIa recruitment to the entry site

    4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vezt):

    cellularembryogenesislethality-prenatal/perinatalnormal

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  VEZT 


    4 Interacting proteins for VEZT (ENSP000002612193) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYO7AENSP000003511053STRING (score=.979)
    CDH1ENSP000002687943STRING (score=.881)
    CTNNB1ENSP000003444563STRING (score=.859)
    CTNNA1ENSP000003471903STRING (score=.722)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for VEZT

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VEZT)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017599

                  Sigma-Aldrich siRNA for VEZT  
                         Sigma-Aldrich shRNA for VEZT  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_017599  

    REFSEQ mRNAs for VEZT gene: 

    NM_017599.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_017599  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017599
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017599
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_017599 

    Additional cDNA sequence: 

    AF216644.1 AF225417.1 AF277625.1 AK001338.1 AK225303.1 AK225356.1 AK307649.1 AK307864.1 
    AK309943.1 AL133113.1 BC014443.1 BC028597.1 BC040845.1 BC064939.1 CR620366.1 

    24/30 DOTS entries (see all 30 ):

    DT.443820  DT.100765984  DT.100801543  DT.101976297  DT.86842133  DT.101976753  DT.97843430  DT.75195511 
    DT.100844504  DT.121163603  DT.95293181  DT.452357  DT.100796102  DT.100796103  DT.121163521  DT.121163613 
    DT.121163469  DT.121163726  DT.40306476  DT.91750036  DT.97808641  DT.100796098  DT.40193626  DT.91702097 

    24/278 AceView cDNA sequences (see all 278 ):

    BM069559 BU732896 BX417059 AI949818 AI800851 AI627614 BI488964 BP356051 
    AW007647 AA256817 BX345173 BQ231343 BQ430470 H96404 BX398166 BM835317 
    AI803510 AL137497 BX425167 AA760985 AI337288 AA282125 AA227557 BG620964 

    highest scoring ESTs for VEZT:

    AI805297 AA001856 AA054279 AA056251 AA227557 AA282124 AA282125 AA424201 AA446752 AA478490 

    Unigene Cluster for VEZT:

    Vezatin, adherens junctions transmembrane protein
    Hs.24135  [show with all ESTs]
    Unigene Representative Sequence: NM_017599


    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for VEZT (see all 16 )

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^
    SP1:                                -     -           -     -     -     -     -     -                                   -     -                       -     -   
    SP2:                                                                                                                    -     -                                 
    SP3:                                                                                                                    -     -                                 
    SP4:                                -     -           -                 -                                                                                       
    SP5:                                -     -           -     -     -     -     -     -                                   -                             -     -   

    ExUns: 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c · 18d
    SP1:                          -     -     -                     
    SP2:                          -     -     -                     
    SP3:                          -     -                           
    SP4:                                                            
    SP5:                                                            

    About this scheme

    ECgene alternative splicing isoforms for VEZT

    4 Ensembl transcripts including schematic representations:
    ENST00000356859  ENST00000397792  ENST00000261219  ENST00000397796  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    VEZT expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for VEZT

    1 / 2 / 3

    8 probe-sets matching VEZT gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    45723_at2, 3 U95-B 1 1.00 1.00 0.88 0.91 AI805297 1.00 1.00 1.00 1

    60811_at2, 3 U95-C 1 0.62 1.00 0.90 1.09 AW007647 0.60 1.00 0.82 1

    223090_x_at2, 3 U133-B 1 1.00 1.00 -- -- AF225417 0.80 0.83 0.82 1

    223089_at2, 3 U133-B 1 1.00 1.00 -- -- AI805297 1.00 1.00 1.00 1

    223675_s_at2, 3 U133-B 2 1.00 0.95 -- -- AF216644 0.80 0.83 0.82 1

    223090_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    223089_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    223675_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  VEZT for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CAGGAACAGA

    SOURCE GeneReport for Unigene cluster: Hs.24135
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for VEZT gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    VEZT1   -- vezatin, adherens junctions transmembrane protein 93.36(n)
    92.16(a)
    612906  XM_847496.1  XP_852589.1 
    chimpanzee
    (Pan troglodytes)
    VEZT1   -- vezatin, adherens junctions transmembrane protein 99.79(n)
    99.61(a)
    452138  XM_001144315.1  XP_001144315.1 
    cow
    (Bos taurus)
    VEZT1   -- vezatin, adherens junctions transmembrane protein 92.07(n)
    90.23(a)
    535351  XM_865102.2  XP_870195.2 
    rat
    (Rattus norvegicus)
    Vezt1   -- vezatin, adherens junctions transmembrane protein 82.9(n)
    82.69(a)
    299738  NM_001006984.1  NP_001006985.1 
    mouse
    (Mus musculus)
    Vezt1, 5 105
    vezatin, adherens junctions transmembrane protein1, 5 83.48(n)1
    84.56(a)1
    2150081  NM_172538.31  NP_766126.21 
     AI8544085  AK0318485  (see all 14)
    About this table        Species with no ortholog for VEZT

    ENSEMBL Gene Tree for VEZT
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/449 NCBI SNPs in VEZT are shown (see all 449 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 106)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs35961,2
    A,C,F,H,O94220551(-) ACAACT/CGAGAA 1 -- ut319Minor allele frequency- C:0.48MN EU EA WA NA 810
    rs31857011,2
    A,C,F,H,O94219391(+) CAATCC/TTGCTG 1 -- ut3113Minor allele frequency- T:0.14NS MN NA EU EA WA 832
    rs141211,2
    A,C,F,H,O94218525(+) TGGTGA/GTGAGG 1 G/D mis1 ese313Minor allele frequency- G:0.31MN NA EU EA WA 1352
    rs122980291,2
    A,C,F,H94219935(+) CTCTTC/AGGAGC 1 -- ut317Minor allele frequency- A:0.34NA EU EA WA 554
    --
    rs44684241,2
    A,C,F,H94218737(+) AAATTA/CGTAGT 1 -- ut31 ese312Minor allele frequency- C:0.07NS NA EU EA WA 666
    --
    rs10460071,2
    C,F,H94218678(+) TATATA/GTAAAG 1 -- ut31 ese33Minor allele frequency- G:0.24MN EU WA 402
    rs178559331,2
    C,F,H94184313(+) TTCCCA/GCTTGG 1 T/A mis1 ese35Minor allele frequency- G:0.07EU EA WA NA 478
    rs105070511,2
    C,F,H94205728(+) CTCAGG/ATCGAC 1 I/V mis1 ese317Minor allele frequency- A:0.02NS NA EU EA WA 1156
    rs173447381,2
    C,F,H94218074(+) AAGCCG/ATGTTG 1 M/V mis1 ese37Minor allele frequency- A:0.04NA EU EA WA 560
    rs178559341,2
    F,H94218242(+) AAAACT/GCTCTA 1 A/S mis1 ese34Minor allele frequency- G:0.06EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for VEZT (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for VEZT gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55591 HGNC: 18258 AceView: VEZATIN Ensembl:ENSG00000028203 euGenes: HUgn55591
    ECgene: VEZT H-InvDB: VEZT
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for VEZT:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VEZT-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
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     Predesigned and custom siRNAs for VEZT Antibodies for VEZT
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for VEZT Browse small molecules at Sigma-Aldrich
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