Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

VEZT Gene

protein-coding GIFtS: 48
GCID: GC12P095611

vezatin, adherens junctions transmembrane protein

Explore 2 diseases affiliated with
VEZT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Vezatin, Adherens Junctions Transmembrane Protein¹ ²
DKFZP761C241¹
VEZATIN²
Vezatin¹

External Ids:	HGNC: 18258¹	Entrez Gene: 55591²	Ensembl: ENSG00000028203⁷	UniProtKB: Q9HBM0³

ORGUL members:
	NONCODE:n410787

Export aliases for VEZT gene to outside databases

Previous GC identifers: GC12P094115 GC12P092680

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VEZT:

This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin

VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which

appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of

a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the

X chromosome. Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0

Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case

of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry

site

Gene Wiki entry for VEZT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VEZT gene promoter:
AML1a Pbx1a LCR-F1 NF-kappaB GATA-1 NF-kappaB2 FOXJ2 (long isoform) Cart-1 FOXJ2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: VEZT promoter sequence

Search SABiosciences Chromatin IP Primers for VEZT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEZT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q22

VEZT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEZT gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P095611: view genomic region (about GC identifiers)

Start:	95,611,522 bp from pter	End:	95,696,566 bp from pter
Size:	85,045 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0 (See protein sequence)

Recommended Name: Vezatin

Size: 779 amino acids; 88665 Da

Subunit: Interacts with myosin VIIa and the cadherin-catenins complex

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus.

Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity)

Sequence caution: Sequence=AAG38514.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown

origin in the N-terminal part; Sequence=AAH64939.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Sequence=BAA91634.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAB70772.2; Type=Miscellaneous

discrepancy; Note=Intron retention;

Secondary accessions: Q6P1Q3 Q9H2F4 Q9H2U5 Q9NT70 Q9NVW0 Q9UF91

Alternative splicing: 4 isoforms: Q9HBM0-1 Q9HBM0-2 Q9HBM0-5 Q9HBM0-6 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for VEZT: NX_Q9HBM0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HBM0

VEZT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060069.3

ENSEMBL proteins:

ENSP00000449056 ENSP00000410083 ENSP00000447891 ENSP00000449346 ENSP00000449591

ENSP00000447080 ENSP00000448866 ENSP00000447010 ENSP00000449701 ENSP00000447044

ENSP00000448019 ENSP00000448555 ENSP00000446666 ENSP00000447786 ENSP00000448738

ENSP00000448724 ENSP00000447633 ENSP00000447468 ENSP00000450009 ENSP00000447151

ENSP00000380894 ENSP00000261219

Human Recombinant Protein Products for VEZT:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: VEZT Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for VEZT
	GenScript Custom Purified and Recombinant Proteins Services for VEZT
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for VEZT

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001669	acrosomal vesicle	IEA	--
GO:0002142	stereocilia ankle link complex	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005912	adherens junction	IEA	--

VEZT for ontologies About GeneDecksing

VEZT Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for VEZT
	GenScript Custom Superior Antibodies Services for VEZT
	Novus Biologicals VEZT Antibodies
	Abcam antibodies for VEZT
	Uscn Antibodies for VEZT
	Search ThermoFisher Antibodies for VEZT

Assay Products for VEZT:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VEZT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VEZT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VEZT for domains About GeneDecksing

2 InterPro domains/families:

IPR026858 Vezatin

IPR026859 Myosin-bd

Graphical View of Domain Structure for InterPro Entry Q9HBM0

ProtoNet protein and cluster: Q9HBM0

UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0

Similarity: Belongs to the vezatin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: VEZA_HUMAN, Q9HBM0

Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case

of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry

site

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0017022	myosin binding	IEA	--

VEZT for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for VEZT:

Decreased cell number

G0/1 arrest

Increased gamma-H2AX phosphory

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vezt):

cellular

embryogenesis

mortality/aging

normal

reproductive system

VEZT for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Vezt^tm1.1Smc for VEZT

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VEZT

miRNA Products:		miRTarBase miRNAs that target VEZT: hsa-mir-30a (MIRT004780)

		OriGene 3'-UTR Clone: VEZT Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEZT
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate VEZT (see all 22):
		hsa-miR-3128 hsa-miR-938 hsa-miR-340 hsa-miR-606 hsa-miR-548a-3p hsa-miR-144 hsa-miR-204 hsa-miR-2276

		SwitchGear 3'UTR luciferase reporter plasmid: VEZT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VEZT (see all 7) OriGene shRNA RFP: VEZT OriGene siRNA: VEZT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEZT
		Sirion Biotech Custom design and validation of potent shRNA sequences against VEZT

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for VEZT
			Sirion Biotech Customized adenovirus for overexpression of VEZT Sirion Biotech Customized adenovirus for potent knockdown of VEZT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEZT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEZT (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: VEZT (NM_017599)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEZT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEZT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for VEZT
		Search LifeMap BioReagents cell lines for VEZT
		Sirion Biotech Customized stable knockdown cell line services for VEZT Sirion Biotech Customized inducible knockdown cell line services for VEZT Sirion Biotech Customized stable overexpressing cell line services for VEZT Sirion Biotech Customized inducible overexpressing cell line services for VEZT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEZT

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VEZT

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for VEZT (Q9HBM0³ ENSP00000410083⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYO7A	Q13402³, ENSP00000386331⁴	I2D: score=2 STRING: ENSP00000386331
CDH1	P12830³, ENSP00000261769⁴	I2D: score=1 STRING: ENSP00000261769
CTNNA1	P35221³, ENSP00000304669⁴	I2D: score=1 STRING: ENSP00000304669
CTNNB1	P35222³, ENSP00000344456⁴	I2D: score=1 STRING: ENSP00000344456
DFNB31	ENSP00000354623⁴	STRING: ENSP00000354623

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016337	cell-cell adhesion	IEA	--
GO:0043009	chordate embryonic development	IEA	--

VEZT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VEZT
Search CenterWatch for drugs/clinical trials and news about VEZT / VEZA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for VEZT gene:

NM_017599.3

Unigene Cluster for VEZT:

Vezatin, adherens junctions transmembrane protein

Hs.24135 [show with all ESTs]

Unigene Representative Sequence: NR_038241

18/41 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 41):

ENST00000549589 ENST00000550803 ENST00000436874(uc001tdr.2 uc009zsz.1 uc001tds.3 uc001tdz.2 uc001tdv.3 uc009ztc.1 uc001tdy.2)

ENST00000547611(uc009zsy.1) ENST00000547997(uc001tdt.2) ENST00000549002

ENST00000546557 ENST00000551746 ENST00000548838 ENST00000547484 ENST00000551472

ENST00000551792 ENST00000553063 ENST00000548455 ENST00000546398 ENST00000552031

ENST00000548822 ENST00000549624

miRNA Products:		OriGene 3'-UTR Clone: VEZT Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEZT
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate VEZT (see all 22):
		hsa-miR-3128 hsa-miR-938 hsa-miR-340 hsa-miR-606 hsa-miR-548a-3p hsa-miR-144 hsa-miR-204 hsa-miR-2276

		SwitchGear 3'UTR luciferase reporter plasmid: VEZT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VEZT (see all 7) OriGene shRNA RFP: VEZT OriGene siRNA: VEZT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEZT
		Sirion Biotech Custom design and validation of potent shRNA sequences against VEZT

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEZT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEZT (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: VEZT (NM_017599)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEZT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEZT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VEZT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat VEZT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VEZT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEZT

Additional cDNA sequence:

AF216644.1 AF225417.1 AF277625.1 AK001338.1 AK225303.1 AK225356.1 AK307649.1 AK307864.1

AK309943.1 AL133113.1 BC014443.1 BC028597.1 BC040845.1 BC064939.1 NR_038241.1 NR_038242.1

24/30 DOTS entries (see all 30):

DT.443820 DT.100765984 DT.100801543 DT.101976297 DT.86842133 DT.101976753 DT.75195511 DT.97843430

DT.100844504 DT.121163603 DT.95293181 DT.452357 DT.100796102 DT.100796103 DT.121163521 DT.121163613

DT.121163469 DT.121163726 DT.91750036 DT.97808641 DT.100796098 DT.40193626 DT.91702097 DT.121163462

24/278 AceView cDNA sequences (see all 278):

AA282125 AA410428 CR620366 AA227557 BC014443 CK904578 AA256277 BF928449

BG620964 AA760985 AA953885 BQ430470 AI800851 AL137497 BI488964 BM835317

AW117975 BX425167 AI342360 AI337288 BP367633 AW475022 BM054892 BX379232

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for VEZT (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	·	10d	^	11a	·	11b	·	11c	^	12	^	13a	·	13b	·	13c	^
SP1:											-		-				-		-		-		-		-		-												-		-								-		-
SP2:																																							-		-
SP3:																																							-		-
SP4:											-		-				-						-
SP5:											-		-				-		-		-		-		-		-												-										-		-

ExUns:	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	·	18c	·	18d
SP1:									-		-		-
SP2:									-		-		-
SP3:									-		-
SP4:
SP5:

ECgene alternative splicing isoforms for VEZT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

VEZT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGAACAGA

About this image

VEZT expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Retina

Eye

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See VEZT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VEZT

SOURCE GeneReport for Unigene cluster: Hs.24135

SABiosciences Expression via Pathway-Focused PCR Array including VEZT:

Adherens Junctions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VEZT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat VEZT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VEZT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEZT

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEZT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for VEZT gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Vezt^{1 , 5}	vezatin, adherens junctions transmembrane protein^{1, 5}	83.48(n)¹ 84.56(a)¹		10 (48.72 cM)⁵ 215008¹ NM_172538.4¹ NP_766126.2¹ 93939165⁵
chicken (Gallus gallus)	Aves	VEZT¹	vezatin, adherens junctions transmembrane protein	74.21(n) 68.95(a)		417911 XM_416152.3 XP_416152.2
lizard (Anolis carolinensis)	Reptilia	VEZT⁶	--	67(a)	1 ↔ 1	5(30864151-30886173)
African clawed frog (Xenopus laevis)	Amphibia	MGC69081²	hypothetical protein MGC69081	76.89(n)		BC059333.1
zebrafish (Danio rerio)	Actinopterygii	vetz¹	vezatin, adherens junctions transmembrane protein	54.31(n) 48.17(a)		100136856 NM_001114575.1 NP_001108047.1

ENSEMBL Gene Tree for VEZT (if available)
TreeFam Gene Tree for VEZT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for VEZT gene

VEZT for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for VEZT
PGOHUM00000241264

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5800197^1,2	C	--	92734316(+)	`TGAAG-/GAAAAA`	1	--	int¹ trp³		2		NA CSA	4
rs200763360^1,2	C	--	92734316(+)	`ATGAAA/GGAAAA`	1	--	int¹		0	--	--	--	--
rs144566052^1,2		--	95609572(+)	`CCTTAC/TAAACT`	4	--	us2k¹ int¹		0	--	--	--	--
rs148027994^1,2		--	95609608(+)	`ACATAC/TAAGAC`	4	--	us2k¹ int¹		0	--	--	--	--
rs1488642^1,2	C	--	95609692(-)	`AAAGTG/AGTTGG`	4	--	int¹ us2k¹		7		NA EA MN WA	668
rs182093367^1,2		--	95609714(+)	`AATTTC/TTTGAA`	4	--	int¹ us2k¹		0	--	--	--	--
rs186297055^1,2		--	95609806(+)	`GTTTAC/TAAAGA`	4	--	int¹ us2k¹		0	--	--	--	--
rs60755216^1,2	C	--	95609819(+)	`TCTCAT/CATAAG`	4	--	us2k¹ int¹		3		WA NA	240
rs143777194^1,2		--	95609845(+)	`AAAGGA/CAAGAC`	4	--	us2k¹ int¹		0	--	--	--	--
rs188711489^1,2		--	95609989(+)	`TGAGTA/GCTGTT`	4	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for VEZT (95611522 - 95696566 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VEZT: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VEZT

DNA2.0 Custom Variant and Variant Library Synthesis for VEZT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VEZT for disorders About GeneDecksing

2 diseases for VEZT: About MalaCards

gastric cancer hypotrichosis

Export disorders for VEZT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for VEZT gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with VEZT)

Utopia: connect your pdf to the dynamic
world of online information

Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. (PubMed id 11080149)^{1, 2, 3, 9} Kuessel-Andermann P.... Petit C. (2000)
Down-regulation of VEZT gene expression in human gast ric cancer involves promoter methylation and miR-43c. (PubMed id 21156161)^{1, 3} Guo X....Li C. (2011)
Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. (PubMed id 16199027)^{1, 3} Hyenne V....Simmler M.C. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells. (PubMed id 15090598)^{2, 9} Sousa S....Cossart P. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55591	HGNC: 18258	AceView: VEZATIN	Ensembl:ENSG00000028203	euGenes: HUgn55591
ECgene: VEZT	H-InvDB: VEZT

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for VEZT	Pharmacogenomics, SNPs, Pathways

Intellectual Property for VEZT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for VEZT gene:
Search GeneIP for patents involving VEZT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for VEZT
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VEZT		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VEZT
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for VEZT		OriGene 3'-UTR Clone for VEZT
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEZT		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEZT
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for VEZT		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for VEZT		OriGene Custom Protein Services for VEZT
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VEZT
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VEZT
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEZT
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEZT
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEZT
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VEZT

	GenScript Custom Purified and Recombinant Proteins Services for VEZT		GenScript cDNA clones with any tag delivered in your preferred vector for VEZT
	GenScript Custom Assay Services for VEZT		GenScript Custom Superior Antibodies Services for VEZT
	GenScript Custom overexpressing Cell Line Services for VEZT		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in VEZT promoter
	Search Chromatin IP Primers for VEZT
	RT² qPCR Primer Assay in human, mouse, rat VEZT
	GNC Network for VEZT
	SABiosciences PCR Arrays including human, mouse, rat VEZT

Search Tocris compounds for VEZT

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	VEZT antibodies

	Antibodies for VEZT
	See all of Abcam's Antibodies, Kits and Proteins for VEZT
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

VEZT Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for VEZT

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEZT

	SwitchGear 3'UTR luciferase reporter plasmids for VEZT
	SwitchGear Promoter luciferase reporter plasmids for VEZT

Search ThermoFisher Antibodies for VEZT

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEZT

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for VEZT

Sirion Biotech Customized:

	stable knockdown cell line services for VEZT
	inducible knockdown cell line services for VEZT
	design and validation of potent shRNA sequences against VEZT
	adenovirus for potent knockdown of VEZT
	adenovirus for overexpression of VEZT
	stable overexpressing cell line services for VEZT
	inducible overexpressing cell line services for VEZT

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes VEZT gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

VEZT Gene

vezatin, adherens junctions transmembrane protein

Aliases
for VEZT gene

Summaries
for VEZT gene

Genomic Views
for VEZT gene

Proteins
for VEZT gene

Protein Domains /
Families
for VEZT gene

Function
for VEZT gene

Pathways & Interactions
for VEZT gene

Drugs & Compounds
for VEZT gene

Transcripts
for VEZT gene

Expression
for VEZT gene

Orthologs
for VEZT gene

Paralogs
for VEZT gene

Genomic Variants
for VEZT gene

Disorders / Diseases
for VEZT gene

Publications
for VEZT gene

External Searches for VEZT gene

Genome Databases showing VEZT gene

Other Databases showing VEZT gene

Specialized Databases showing VEZT gene

Intellectual Property
for VEZT gene

Products
for VEZT gene

View Random Gene

Advanced Search

Export list of displayed genes

VEZT Gene

vezatin, adherens junctions transmembrane protein

Aliasesfor VEZT gene

Summariesfor VEZT gene

Genomic Viewsfor VEZT gene

Proteinsfor VEZT gene

Protein Domains /Familiesfor VEZT gene

Functionfor VEZT gene

Pathways & Interactionsfor VEZT gene

Drugs & Compoundsfor VEZT gene

Transcriptsfor VEZT gene

Expression for VEZT gene

Orthologsfor VEZT gene

Paralogsfor VEZT gene

Genomic Variantsfor VEZT gene

Disorders / Diseasesfor VEZT gene

Publicationsfor VEZT gene

External Searches for VEZT gene

Genome Databases showing VEZT gene

Other Databases showing VEZT gene

Specialized Databases showing VEZT gene

Intellectual Propertyfor VEZT gene

Productsfor VEZT gene

View Random Gene

Aliases
for VEZT gene

Summaries
for VEZT gene

Genomic Views
for VEZT gene

Proteins
for VEZT gene

Protein Domains /
Families
for VEZT gene

Function
for VEZT gene

Pathways & Interactions
for VEZT gene

Drugs & Compounds
for VEZT gene

Transcripts
for VEZT gene

Expression
for VEZT gene

Orthologs
for VEZT gene

Paralogs
for VEZT gene

Genomic Variants
for VEZT gene

Disorders / Diseases
for VEZT gene

Publications
for VEZT gene

Intellectual Property
for VEZT gene

Products
for VEZT gene