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VEZT Gene

protein-coding   GIFtS: 50
GCID: GC12P095611

Vezatin, Adherens Junctions Transmembrane Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Vezatin, Adherens Junctions Transmembrane Protein1 2
VEZATIN2
vezatin2

External Ids:    HGNC: 182581   Entrez Gene: 555912   Ensembl: ENSG000000282037   UniProtKB: Q9HBM03   
ORGUL members:         

Export aliases for VEZT gene to outside databases

Previous GC identifers: GC12P094115 GC12P092680


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for VEZT Gene:
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to
myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is
decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be
inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene
of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, May 2011)

GeneCards Summary for VEZT Gene:
VEZT (vezatin, adherens junctions transmembrane protein) is a protein-coding gene. GO annotations related to this gene include myosin binding.

UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0
Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In
case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the
entry site

Gene Wiki entry for VEZT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the VEZT gene promoter:
         AML1a   Pbx1a   LCR-F1   NF-kappaB   GATA-1   NF-kappaB2   FOXJ2 (long isoform)   Cart-1   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidVEZT promoter sequence
   Search Chromatin IP Primers for VEZT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat VEZT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q22

VEZT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEZT gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P095611:  view genomic region     (about GC identifiers)

Start:
95,611,522 bp from pter      End:
95,696,566 bp from pter
Size:
85,045 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0 (See protein sequence)
Recommended Name: Vezatin  
Size: 779 amino acids; 88665 Da
Subunit: Interacts with myosin VIIa and the cadherin-catenins complex
Sequence caution: Sequence=AAG38514.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=AAH64939.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Sequence=BAA91634.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAB70772.2;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q6P1Q3 Q9H2F4 Q9H2U5 Q9NT70 Q9NVW0 Q9UF91
Alternative splicing: 4 isoforms:  Q9HBM0-1   Q9HBM0-2   Q9HBM0-5   Q9HBM0-6   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for VEZT: NX_Q9HBM0

Explore proteomics data for VEZT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See VEZT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060069.3  
    ENSEMBL proteins: 
     ENSP00000449056   ENSP00000410083   ENSP00000447891   ENSP00000449346   ENSP00000449591  
     ENSP00000447080   ENSP00000448866   ENSP00000447010   ENSP00000449701   ENSP00000447044  
     ENSP00000448019   ENSP00000448555   ENSP00000446666   ENSP00000447786   ENSP00000448738  
     ENSP00000448724   ENSP00000447633   ENSP00000447468   ENSP00000450009   ENSP00000447151  
     ENSP00000380894   ENSP00000261219  

    VEZT Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VEZT

     
    Search eBioscience for Proteins for VEZT 

    VEZT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for VEZT at Abcam
    Cloud-Clone Corp. Antibodies for VEZT
    ThermoFisher Antibody for VEZT
    LSBio Antibodies in human, mouse, rat for VEZT

    VEZT Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for VEZT
    Cloud-Clone Corp. CLIAs for VEZT
    Search eBioscience for ELISAs for VEZT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026859 Myosin-bd
     IPR026858 Vezatin

    Graphical View of Domain Structure for InterPro Entry Q9HBM0

    ProtoNet protein and cluster: Q9HBM0

    UniProtKB/Swiss-Prot: VEZA_HUMAN, Q9HBM0
    Similarity: Belongs to the vezatin family


    Find genes that share domains with VEZT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VEZA_HUMAN, Q9HBM0
    Function: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In
    case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the
    entry site

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017022myosin binding IEA--
         
    Find genes that share ontologies with VEZT           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for VEZT:
     Decreased cell number  G0/1 arrest  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Vezt):
     cellular  embryogenesis  mortality/aging  normal  reproductive system 

    Find genes that share phenotypes with VEZT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Vezttm1.1Smc for VEZT

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for VEZT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for VEZT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VEZT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VEZT

    miRNA
    Products:
        
    miRTarBase miRNAs that target VEZT:
    hsa-mir-16-5p (MIRT031725), hsa-mir-375 (MIRT019856), hsa-mir-101-3p (MIRT027346), hsa-mir-103a-3p (MIRT027075), hsa-mir-30a-3p (MIRT004780)

    Block miRNA regulation of human, mouse, rat VEZT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VEZT (see all 22):
    hsa-miR-3128 hsa-miR-938 hsa-miR-340 hsa-miR-606 hsa-miR-548a-3p hsa-miR-144 hsa-miR-204 hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmidVEZT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for VEZT
    Predesigned siRNA for gene silencing in human, mouse, rat VEZT

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for VEZT

    Clone
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    OriGene clones in human, mouse for VEZT (see all 8)
    OriGene ORF clones in mouse, rat for VEZT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VEZT (NM_017599)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEZT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEZT

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for VEZT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEZT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VEZA_HUMAN, Q9HBM0: Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus.
    Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0002142stereocilia ankle link complex IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with VEZT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including VEZT: 
              Adherens Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for VEZT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for VEZT (Q9HBM03 ENSP000004100834) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYO7AQ134023, ENSP000003863314I2D: score=2 STRING: ENSP00000386331
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CTNNA1P352213, ENSP000003046694I2D: score=1 STRING: ENSP00000304669
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    DFNB31ENSP000003546234STRING: ENSP00000354623
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0043009chordate embryonic development IEA--

    Find genes that share ontologies with VEZT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for VEZT (VEZA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for VEZT gene: 
    NM_017599.3  

    Unigene Cluster for VEZT:

    Vezatin, adherens junctions transmembrane protein
    Hs.24135  [show with all ESTs]
    Unigene Representative Sequence: NR_038241
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 41):
    ENST00000549589 ENST00000550803 ENST00000436874(uc001tdr.2 uc009zsz.1 uc001tds.3 uc001tdz.2 uc001tdv.3 uc009ztc.1 uc001tdy.2)
    ENST00000547611(uc009zsy.1) ENST00000547997(uc001tdt.2) ENST00000549002
    ENST00000546557 ENST00000551746 ENST00000548838 ENST00000547484 ENST00000551472
    ENST00000551792 ENST00000553063 ENST00000548455 ENST00000546398 ENST00000552031
    ENST00000548822 ENST00000549624
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat VEZT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate VEZT (see all 22):
    hsa-miR-3128 hsa-miR-938 hsa-miR-340 hsa-miR-606 hsa-miR-548a-3p hsa-miR-144 hsa-miR-204 hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmidVEZT 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for VEZT
    Predesigned siRNA for gene silencing in human, mouse, rat VEZT
    Clone
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    OriGene clones in human, mouse for VEZT (see all 8)
    OriGene ORF clones in mouse, rat for VEZT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: VEZT (NM_017599)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEZT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEZT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VEZT
    OriGene qSTAR qPCR primer pairs in human, mouse for VEZT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VEZT
      QuantiTect SYBR Green Assays in human, mouse, rat VEZT
      QuantiFast Probe-based Assays in human, mouse, rat VEZT

    Additional mRNA sequence: 

    AF216644.1 AF225417.1 AF277625.1 AK001338.1 AK225303.1 AK225356.1 AK307649.1 AK307864.1 
    AK309943.1 AL133113.1 BC014443.1 BC028597.1 BC040845.1 BC064939.1 NR_038241.1 NR_038242.1 

    Selected DOTS entries (see all 30):

    DT.443820  DT.100765984  DT.100801543  DT.101976297  DT.86842133  DT.101976753  DT.75195511  DT.97843430 
    DT.100844504  DT.121163603  DT.95293181  DT.452357  DT.100796102  DT.100796103  DT.121163521  DT.121163613 
    DT.121163469  DT.121163726  DT.91750036  DT.97808641  DT.100796098  DT.40193626  DT.91702097  DT.121163462 

    Selected AceView cDNA sequences (see all 278):

    AI627614 BM835317 AA256817 BP367633 AA760985 BF928449 H96404 BX379232 
    AL137497 BI488964 BQ430470 BX345173 AI803510 AA705887 AA227557 BM069800 
    BX398166 BM054699 BU732896 BM054892 BX461605 BX417059 AA410428 BP356051 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for VEZT (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^
    SP1:                                -     -           -     -     -     -     -     -                                   -     -                       -     -   
    SP2:                                                                                                                    -     -                                 
    SP3:                                                                                                                    -     -                                 
    SP4:                                -     -           -                 -                                                                                       
    SP5:                                -     -           -     -     -     -     -     -                                   -                             -     -   

    ExUns: 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c · 18d
    SP1:                          -     -     -                     
    SP2:                          -     -     -                     
    SP3:                          -     -                           
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for VEZT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    VEZT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAACAGA
    VEZT Expression
    About this image


    VEZT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    VEZT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    VEZT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24135
        Pathway & Disease-focused RT2 Profiler PCR Array including VEZT: 
              Adherens Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for VEZT
    OriGene qSTAR qPCR primer pairs in human, mouse for VEZT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat VEZT
    QuantiTect SYBR Green Assays in human, mouse, rat VEZT
    QuantiFast Probe-based Assays in human, mouse, rat VEZT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEZT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for VEZT gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Vezt1 , 5 vezatin, adherens junctions transmembrane protein1, 5 83.84(n)1
    85.11(a)1
      10 (48.72 cM)5
    2150081  NM_172538.41  NP_766126.21 
     939391655 
    chicken
    (Gallus gallus)
    Aves VEZT1 vezatin, adherens junctions transmembrane protein 74.38(n)
    69.25(a)
      417911  XM_416152.4  XP_416152.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690812 hypothetical protein MGC69081 76.89(n)    BC059333.1 
    zebrafish
    (Danio rerio)
    Actinopterygii vetz1 vezatin, adherens junctions transmembrane protein 54.9(n)
    49.23(a)
      100136856  NM_001114575.2  NP_001108047.1 


    ENSEMBL Gene Tree for VEZT (if available)
    TreeFam Gene Tree for VEZT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for VEZT gene

    Find genes that share paralogs with VEZT           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for VEZT
    PGOHUM00000241264


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for VEZT (see all 1650)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445660521,2
    --95451493(+) CCTTAC/TAAACT 3 -- us2k10--------
    rs1480279941,2
    --95451529(+) ACATAC/TAAGAC 3 -- us2k10--------
    rs14886421,2
    C--95451613(-) AAAGTG/AGTTGG 3 -- us2k17Minor allele frequency- A:0.06NA EA MN WA 668
    rs1820933671,2
    --95451635(+) AATTTC/TTTGAA 3 -- us2k10--------
    rs1862970551,2
    --95451727(+) GTTTAC/TAAAGA 3 -- us2k10--------
    rs607552161,2
    C,F--95451740(+) TCTCAT/CATAAG 3 -- us2k13Minor allele frequency- C:0.11WA NA 240
    rs1437771941,2
    --95451766(+) AAAGGA/CAAGAC 3 -- us2k10--------
    rs1887114891,2
    --95451910(+) TGAGTA/GCTGTT 3 -- us2k10--------
    rs73108331,2
    C,F,A,H--95452141(+) CTTACA/GAAGTG 3 -- us2k112Minor allele frequency- G:0.46NS NA WA CSA EA 484
    rs1168233041,2
    C,F--95452296(+) CAGACA/GGAAAA 3 -- us2k11Minor allele frequency- G:0.06WA 118

    HapMap Linkage Disequilibrium report for VEZT (95611522 - 95696566 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for VEZT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899451CNV Loss21882294
    nsv899449CNV Loss21882294
    nsv899450CNV Gain21882294
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing VEZT
    DNA2.0 Custom Variant and Variant Library Synthesis for VEZT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with VEZT           About GenesLikeMe

    Genetic Association Database (GAD): VEZT

    Export disorders for VEZT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for VEZT gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with VEZT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. (PubMed id 11080149)1, 2, 3, 9 Kuessel-Andermann P.... Petit C. (EMBO J. 2000)
    2. Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c. (PubMed id 21156161)1, 3 Guo X....Li C. (Biochem. Biophys. Res. Commun. 2011)
    3. Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. (PubMed id 16199027)1, 3 Hyenne V....Simmler M.C. (Dev. Biol. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells. (PubMed id 15090598)2, 9 Sousa S.... Cossart P. (J. Cell Sci. 2004)
    6. Genome-wide association study link novel loci to endometriosis. (PubMed id 23472165)1 Albertsen H.M....Ward K. (PLoS ONE 2013)
    7. Genome-wide association meta-analysis identifies new endometriosis risk loci. (PubMed id 23104006)1 Nyholt D.R....Montgomery G.W. (Nat. Genet. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55591 HGNC: 18258 AceView: VEZATIN Ensembl:ENSG00000028203 euGenes: HUgn55591
    ECgene: VEZT H-InvDB: VEZT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for VEZT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for VEZT gene:
    Search GeneIP for patents involving VEZT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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