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Aliases for VEZT Gene

Aliases for VEZT Gene

  • Vezatin, Adherens Junctions Transmembrane Protein 2 3
  • VEZATIN 3

External Ids for VEZT Gene

Previous GeneCards Identifiers for VEZT Gene

  • GC12P094115
  • GC12P095611
  • GC12P092680

Summaries for VEZT Gene

Entrez Gene Summary for VEZT Gene

  • This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

GeneCards Summary for VEZT Gene

VEZT (Vezatin, Adherens Junctions Transmembrane Protein) is a Protein Coding gene. GO annotations related to this gene include myosin binding.

UniProtKB/Swiss-Prot for VEZT Gene

  • Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site.

Gene Wiki entry for VEZT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEZT Gene

Genomics for VEZT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VEZT Gene

Chromosome:
12
Start:
95,217,746 bp from pter
End:
95,302,790 bp from pter
Size:
85,045 bases
Orientation:
Plus strand

Genomic View for VEZT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VEZT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEZT Gene

Proteins for VEZT Gene

  • Protein details for VEZT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBM0-VEZA_HUMAN
    Recommended name:
    Vezatin
    Protein Accession:
    Q9HBM0
    Secondary Accessions:
    • Q6P1Q3
    • Q9H2F4
    • Q9H2U5
    • Q9NT70
    • Q9NVW0
    • Q9UF91

    Protein attributes for VEZT Gene

    Size:
    779 amino acids
    Molecular mass:
    88665 Da
    Quaternary structure:
    • Interacts with myosin VIIa and the cadherin-catenins complex.
    SequenceCaution:
    • Sequence=AAG38514.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH64939.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAA91634.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAB70772.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for VEZT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VEZT Gene

Proteomics data for VEZT Gene at MOPED

Post-translational modifications for VEZT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VEZT Gene

Domains & Families for VEZT Gene

Protein Domains for VEZT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for VEZT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBM0

UniProtKB/Swiss-Prot:

VEZA_HUMAN :
  • Belongs to the vezatin family.
Family:
  • Belongs to the vezatin family.
genes like me logo Genes that share domains with VEZT: view

No data available for Gene Families for VEZT Gene

Function for VEZT Gene

Molecular function for VEZT Gene

UniProtKB/Swiss-Prot Function:
Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site.

Gene Ontology (GO) - Molecular Function for VEZT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017022 myosin binding IEA --
genes like me logo Genes that share ontologies with VEZT: view
genes like me logo Genes that share phenotypes with VEZT: view

Animal Models for VEZT Gene

MGI Knock Outs for VEZT:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VEZT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for VEZT Gene

Localization for VEZT Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEZT Gene

Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VEZT Gene COMPARTMENTS Subcellular localization image for VEZT gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for VEZT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0002142 stereocilia ankle link complex IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with VEZT: view

Pathways & Interactions for VEZT Gene

SuperPathways for VEZT Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for VEZT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0043009 chordate embryonic development IEA --
genes like me logo Genes that share ontologies with VEZT: view

No data available for Pathways by source and SIGNOR curated interactions for VEZT Gene

Drugs & Compounds for VEZT Gene

No Compound Related Data Available

Transcripts for VEZT Gene

Unigene Clusters for VEZT Gene

Vezatin, adherens junctions transmembrane protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VEZT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEZT Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^
SP1: - - - - - - - - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: -
SP12: - - - -
SP13:
SP14:
SP15:
SP16: - -

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c · 18d
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:

Relevant External Links for VEZT Gene

GeneLoc Exon Structure for
VEZT
ECgene alternative splicing isoforms for
VEZT

Expression for VEZT Gene

mRNA expression in normal human tissues for VEZT Gene

Protein differential expression in normal tissues from HIPED for VEZT Gene

This gene is overexpressed in Nasal epithelium (53.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VEZT Gene



SOURCE GeneReport for Unigene cluster for VEZT Gene Hs.24135

genes like me logo Genes that share expression patterns with VEZT: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for VEZT Gene

Orthologs for VEZT Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEZT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VEZT 35
  • 92.07 (n)
  • 90.23 (a)
VEZT 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VEZT 35
  • 93.32 (n)
  • 92.16 (a)
VEZT 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vezt 35
  • 83.84 (n)
  • 85.11 (a)
Vezt 16
Vezt 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VEZT 35
  • 99.79 (n)
  • 99.61 (a)
VEZT 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vezt 35
  • 83.25 (n)
  • 83.47 (a)
oppossum
(Monodelphis domestica)
Mammalia VEZT 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VEZT 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves VEZT 35
  • 74.38 (n)
  • 69.25 (a)
VEZT 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11013 35
vezt 35
  • 64.79 (n)
  • 61.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69081 35
zebrafish
(Danio rerio)
Actinopterygii vetz 35
  • 54.9 (n)
  • 49.23 (a)
vetz 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for VEZT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEZT Gene

ENSEMBL:
Gene Tree for VEZT (if available)
TreeFam:
Gene Tree for VEZT (if available)

Paralogs for VEZT Gene

Pseudogenes.org Pseudogenes for VEZT Gene

genes like me logo Genes that share paralogs with VEZT: view

No data available for Paralogs for VEZT Gene

Variants for VEZT Gene

Sequence variations from dbSNP and Humsavar for VEZT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3596 -- 95,302,644(-) ACAAC(C/T)GAGAA utr-variant-3-prime, nc-transcript-variant
rs14121 - 95,300,618(+) TGGTG(A/G)TGAGG missense, reference, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs923371 -- 95,222,833(-) GTTGC(C/T)TGATT intron-variant
rs1038652 -- 95,265,236(+) ACTTG(C/T)AATTG intron-variant
rs1038653 -- 95,266,089(+) CTTTA(C/T)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VEZT Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv899449 CNV Loss 21882294
nsv899450 CNV Gain 21882294
nsv899451 CNV Loss 21882294

Variation tolerance for VEZT Gene

Residual Variation Intolerance Score: 90.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VEZT Gene

HapMap Linkage Disequilibrium report
VEZT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEZT Gene

Disorders for VEZT Gene

Relevant External Links for VEZT

Genetic Association Database (GAD)
VEZT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VEZT
genes like me logo Genes that share disorders with VEZT: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VEZT Gene

Publications for VEZT Gene

  1. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. (PMID: 11080149) Kuessel-Andermann P. … Petit C. (EMBO J. 2000) 2 23 67
  2. Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c. (PMID: 21156161) Guo X. … Li C. (Biochem. Biophys. Res. Commun. 2011) 2 67
  3. Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. (PMID: 16199027) Hyenne V. … Simmler M.C. (Dev. Biol. 2005) 2 67
  4. Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells. (PMID: 15090598) Sousa S. … Cossart P. (J. Cell Sci. 2004) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for VEZT Gene

Sources for VEZT Gene

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