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VEZF1 Gene

protein-coding   GIFtS: 49

GC17M053403
vascular endothelial zinc finger 1
(Previous name: zinc finger protein 161 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF161)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DB1 1, 2, 3
ZNF161 2, 3, 5
Descriptions
Putative transcription factor DB1 3
Zinc finger protein 161 1, 2, 3
vascular endothelial zinc finger 1 2
External Ids
HGNC: 129491
Entrez Gene: 77162
UniProtKB: Q141193
Ensembl: ENSG000001364517
Search outside databases for aliases for VEZF1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for VEZF1:
Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to
be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a
C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for
general information on zinc finger proteins.[supplied by OMIM]

UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119
Function: Possible transcription factor. Specifically binds to the CT/GC-rich region of the
interleukin-3 promoter and mediates tax transactivation of IL-3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

VEZF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M053403:     (about GC identifiers)

Start:
53,403,909 bp from pter
End:
53,420,614 bp from pter
Size:
16,706 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010783.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119 (See protein sequence)
Recommended Name: Vascular endothelial zinc finger 1  
Size: 516 amino acids; 56363 Da
Subunit: Interacts with ARHGAP22 (By similarity)
Subcellular location: Nucleus

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_009077.2  

    ENSEMBL proteins: 
    ENSP00000258963 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZNF161)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for VEZF1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZNF161), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for VEZF1

    Assays for VEZF1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2


       GeneDecks  VEZF1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q14119

    ProtoNet protein and cluster: Q14119

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VEZF1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZNF161)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007146

                  Applied Biosystems Silencer® siRNAs for VEZF1

                  Sigma-Aldrich siRNA for VEZF1  
                         Sigma-Aldrich shRNA for VEZF1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007146
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007146
                                     untagged cDNA clone in CMV expression vector: NM_007146 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_007146

    UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119
    Function: Possible transcription factor. Specifically binds to the CT/GC-rich region of the
    interleukin-3 promoter and mediates tax transactivation of IL-3

    5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vezf1):

    embryogenesisgrowth/sizeimmune systemlethality-prenatal/perinatal

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0003704 specific RNA polymerase II transcription factor activity TAS8035792
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for VEZF1 (ENSP000002589633) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EDN1ENSP000003686833STRING (score=.897)
    STMN1ENSP000003505313STRING (score=.895)
    --ENSP000003590513STRING (score=.791)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525 angiogenesis IEA--
    GO:0001885 endothelial cell development IEA--
    GO:0006350 transcription IEA--
    GO:0006357 regulation of transcription from RNA polymerase II promoter TAS8035792
    GO:0006968 cellular defense response TAS8035792
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for VEZF1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VEZF1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZNF161)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007146

                  Sigma-Aldrich siRNA for VEZF1  
                         Sigma-Aldrich shRNA for VEZF1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_007146  

    REFSEQ mRNAs for VEZF1 gene: 

    NM_007146.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_007146  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_007146
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_007146
                                     untagged cDNA clone in CMV expression vector: NM_007146 

    Additional cDNA sequence: 

    AK058024.1 BX648862.1 CR609476.1 D28118.1 

    10 DOTS entries:

    DT.100793587  DT.92431525  DT.95188994  DT.100793579  DT.120850471  DT.40294655  DT.75188496  DT.92431527 
    DT.100793576  DT.120937961 

    24/298 AceView cDNA sequences (see all 298 ):

    AW183892 AA227945 BE669734 AI263125 AA026448 BX109922 BE672621 BM977996 
    AI208612 BU729102 BM669599 BI966844 BM873386 H87224 CK903633 AW079327 
    CR609476 BM676135 AI383027 AI689597 AA746113 CA941584 T92348 AI202735 

    highest scoring ESTs for VEZF1:

    AI128606 D28118 AA033866 AA034054 AA045464 AA115815 AA195025 AA195154 AA232647 AA336595 

    Unigene Cluster for VEZF1:

    Vascular endothelial zinc finger 1
    Hs.463569  [show with all ESTs]
    Unigene Representative Sequence: NM_007146


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000258963  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    VEZF1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for VEZF1

    1 / 2 / 3

    10 probe-sets matching VEZF1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    48573_at2, 3 U95-B 1 1.00 1.00 0.90 1.23 AA452188 0.60 1.00 0.82 1

    32628_at2, 3 U95-A 1 1.00 1.00 0.83 0.74 D28118 0.80 0.88 0.84 1

    54020_at2, 3 U95-B 1 1.00 1.00 0.79 1.48 AA045464 0.60 1.00 0.82 1

    350_at2, 3 U95-A 1 1.00 1.00 0.95 0.56 D28118 0.80 0.88 0.84 1

    202173_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_007146 0.60 1.00 0.82 1

    202172_at2, 3 U133-A 1 1.00 1.00 -- -- BG035116 0.40 1.00 0.76 1

    202171_at2, 3 U133-A 1 1.00 1.00 -- -- AU146275 0.40 1.00 0.76 1

    202173_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202172_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202171_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.463569

    UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119
    Tissue specificity: Ubiquitously expressed. Highest levels in skeletal muscle and kidney

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for VEZF1 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    VEZF11   -- vascular endothelial zinc finger 1 95.71(n)
    99.03(a)
    491106  XM_548226.2  XP_548226.2 
    chimpanzee
    (Pan troglodytes)
    VEZF11   -- vascular endothelial zinc finger 1 99.67(n)
    100(a)
    468416  XM_523805.2  XP_523805.2 
    cow
    (Bos taurus)
    VEZF11   -- vascular endothelial zinc finger 1 93.16(n)
    99.21(a)
    539120  XM_584969.3  XP_584969.1 
    rat
    (Rattus norvegicus)
    Vezf11   -- vascular endothelial zinc finger 1 93.58(n)
    99.02(a)
    287615  XM_213421.4  XP_213421.4 
    mouse
    (Mus musculus)
    Vezf11, 5 115
    vascular endothelial zinc finger 11, 5 94.59(n)1
    98.65(a)1
    223441  NM_016686.31  NP_057895.21 
     AF1044105  AI8486915  (see all 15)
    About this table        Species with no ortholog for VEZF1

    ENSEMBL Gene Tree for VEZF1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for VEZF1 gene
    MAZ2  ENSG000002128502  PATZ12  

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/85 NCBI SNPs in VEZF1 are shown (see all 85 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 39)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs177624341,2
    C,F,H53403641(+) CATCTT/GCTCTT 1 -- ng517Minor allele frequency- G:0.03NA EU EA WA 562
    rs116571281,2
    C,F,H53403839(+) AGAAAG/ATACTT 1 -- ng514Minor allele frequency- A:0.05EU EA WA 420
    rs80672621,2
    F,H53403719(+) CTGCTT/GGGGAG 1 -- ng514Minor allele frequency- G:0.05EU EA WA 416
    rs72085121,2
    F,H53403500(+) CTAATA/GGTGCG 1 -- ng514Minor allele frequency- G:0.04EU EA WA 418
    rs169425631,2
    F,H53421785(+) AGACTT/CTAACA 1 -- ng31 tfbs37Minor allele frequency- C:0.03NA EU EA WA 538
    rs23330791,2
    H53406497(+) CTTGGG/AATTAG 1 -- ut31 ese31Minor allele frequency- A:0.00EU 120
    --
    rs28778521,2
    H53406148(+) TCCATC/TGGGAT 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 418
    --
    rs47939241,2
    H53405033(+) GTGTAG/AGAATG 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 418
    --
    rs11356561,2
    H53407170(-) GTCTGG/AGACTA 1 E/G mis1 ese35Minor allele frequency- A:0.00MN EU EA WA 590
    --
    rs22282701,2
    A,C,F,H53415214(-) AATCGA/GCACAA 1 R/R syn1 ese38Minor allele frequency- G:0.06MN NA EU EA WA 584
    About this table

    HapMap Linkage Disequilibrium images for VEZF1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606747

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    5 PubMed articles for VEZF1 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 7716 HGNC: 12949 AceView: ZNF161 Ensembl:ENSG00000136451 euGenes: HUgn7716
    ECgene: VEZF1 H-InvDB: VEZF1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for VEZF1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VEZF1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for VEZF1 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for VEZF1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
    (ZNF161)
     Antibodies (ZNF161)
     Search OriGene for VEZF1
     Search Tocris compounds for VEZF1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for VEZF1

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