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Aliases for VEZF1 Gene

Aliases for VEZF1 Gene

  • Vascular Endothelial Zinc Finger 1 2 3 5
  • Zinc Finger Protein 161 2 3 4
  • Putative Transcription Factor DB1 3 4
  • ZNF161 3 4
  • DB1 3 4

External Ids for VEZF1 Gene

Previous HGNC Symbols for VEZF1 Gene

  • ZNF161

Previous GeneCards Identifiers for VEZF1 Gene

  • GC17M053403
  • GC17M056048
  • GC17M051410

Summaries for VEZF1 Gene

Entrez Gene Summary for VEZF1 Gene

  • Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]

GeneCards Summary for VEZF1 Gene

VEZF1 (Vascular Endothelial Zinc Finger 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is MAZ.

UniProtKB/Swiss-Prot for VEZF1 Gene

  • Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEZF1 Gene

Genomics for VEZF1 Gene

Regulatory Elements for VEZF1 Gene

Enhancers for VEZF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F058005 2.2 ENCODE 24 -18.2 -18246 4.1 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 SRSF1 VEZF1 ENSG00000264914 OR4D1 LOC101927557 SETP3 CCDC182 IGBP1P2 TEX14 ENSG00000266086
GH17F058657 1.9 FANTOM5 Ensembl ENCODE 22 -670.7 -670652 2.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SRSF1 TRIM37 RAD51C VEZF1 SMG8 SETP3 OR4D1 SPDYE22P ENSG00000264914 CCDC182
GH17F058679 1.2 ENCODE 32 -691.4 -691420 1.3 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF766 CBX5 ZNF143 TRIM37 VEZF1 SRSF1 SMG8 DHX40 RNF43 GC17M058678 GC17M058680 RNU1-52P RNU1-85P
GH17F058327 1.6 FANTOM5 ENCODE 22.7 -349.4 -349399 20.8 HDGF PKNOX1 ARNT WRNIP1 SIN3A YBX1 YY1 SLC30A9 ZNF143 ZNF207 SRSF1 VEZF1 SUPT4H1 TSPOAP1 TRIM37 SMG8 DYNLL2 TEX14 MTMR4 MPO
GH17F058630 1.2 ENCODE 22 -643.6 -643623 2.6 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TRIM37 RAD51C SRSF1 VEZF1 TEX14 RNU1-108P SMG8 MTMR4 DHX40 ENSG00000212195
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around VEZF1 on UCSC Golden Path with GeneCards custom track

Promoters for VEZF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001349817 859 3201 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416

Genomic Location for VEZF1 Gene

Chromosome:
17
Start:
57,971,547 bp from pter
End:
57,988,259 bp from pter
Size:
16,713 bases
Orientation:
Minus strand

Genomic View for VEZF1 Gene

Genes around VEZF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VEZF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VEZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEZF1 Gene

Proteins for VEZF1 Gene

  • Protein details for VEZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14119-VEZF1_HUMAN
    Recommended name:
    Vascular endothelial zinc finger 1
    Protein Accession:
    Q14119

    Protein attributes for VEZF1 Gene

    Size:
    521 amino acids
    Molecular mass:
    56931 Da
    Quaternary structure:
    • Interacts with ARHGAP22.

neXtProt entry for VEZF1 Gene

Post-translational modifications for VEZF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VEZF1 Gene

Domains & Families for VEZF1 Gene

Gene Families for VEZF1 Gene

Protein Domains for VEZF1 Gene

Suggested Antigen Peptide Sequences for VEZF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14119

UniProtKB/Swiss-Prot:

VEZF1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with VEZF1: view

Function for VEZF1 Gene

Molecular function for VEZF1 Gene

UniProtKB/Swiss-Prot Function:
Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.

Gene Ontology (GO) - Molecular Function for VEZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with VEZF1: view
genes like me logo Genes that share phenotypes with VEZF1: view

Animal Models for VEZF1 Gene

MGI Knock Outs for VEZF1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VEZF1 Gene

Localization for VEZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEZF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for VEZF1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for VEZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with VEZF1: view

Pathways & Interactions for VEZF1 Gene

SuperPathways for VEZF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VEZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001885 endothelial cell development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8035792
genes like me logo Genes that share ontologies with VEZF1: view

No data available for Pathways by source and SIGNOR curated interactions for VEZF1 Gene

Transcripts for VEZF1 Gene

Unigene Clusters for VEZF1 Gene

Vascular endothelial zinc finger 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEZF1 Gene

No ASD Table

Relevant External Links for VEZF1 Gene

GeneLoc Exon Structure for
VEZF1
ECgene alternative splicing isoforms for
VEZF1

Expression for VEZF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for VEZF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for VEZF1 Gene

This gene is overexpressed in Ovary (13.6), Peripheral blood mononuclear cells (13.6), Rectum (7.3), and Retina (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for VEZF1 Gene



Protein tissue co-expression partners for VEZF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of VEZF1 Gene:

VEZF1

SOURCE GeneReport for Unigene cluster for VEZF1 Gene:

Hs.463569

mRNA Expression by UniProt/SwissProt for VEZF1 Gene:

Q14119-VEZF1_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with VEZF1: view

Primer Products

No data available for mRNA differential expression in normal tissues for VEZF1 Gene

Orthologs for VEZF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for VEZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VEZF1 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia VEZF1 34 35
  • 95.71 (n)
mouse
(Mus musculus)
Mammalia Vezf1 34 16 35
  • 94.59 (n)
rat
(Rattus norvegicus)
Mammalia Vezf1 34
  • 93.52 (n)
oppossum
(Monodelphis domestica)
Mammalia VEZF1 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VEZF1 34 35
  • 92.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia VEZF1 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves VEZF1 34 35
  • 86.56 (n)
lizard
(Anolis carolinensis)
Reptilia VEZF1 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vezf1 34
  • 73.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29971 34
zebrafish
(Danio rerio)
Actinopterygii vezf1b 34 35
  • 67.81 (n)
vezf1a 35
  • 59 (a)
OneToMany
VEZF1 (3 of 3) 35
  • 34 (a)
OneToMany
Species where no ortholog for VEZF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for VEZF1 Gene

ENSEMBL:
Gene Tree for VEZF1 (if available)
TreeFam:
Gene Tree for VEZF1 (if available)

Paralogs for VEZF1 Gene

Variants for VEZF1 Gene

Sequence variations from dbSNP and Humsavar for VEZF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111532912 -- 57,974,257(+) AAAAG(C/G)AATTT utr-variant-3-prime
rs112102556 -- 57,978,403(+) CCTTT(G/T)GCTCA intron-variant
rs112175123 -- 57,978,533(+) ATACA(A/C/T)GAGAG intron-variant
rs112528240 -- 57,979,122(+) TAGCC(A/G)TATTT intron-variant
rs112914139 -- 57,989,047(+) ATAGA(C/G)AAATT nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for VEZF1 Gene

Variant ID Type Subtype PubMed ID
nsv978441 CNV duplication 23825009
nsv960125 CNV duplication 23825009
nsv833497 CNV loss 17160897

Variation tolerance for VEZF1 Gene

Residual Variation Intolerance Score: 8.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VEZF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
VEZF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEZF1 Gene

Disorders for VEZF1 Gene

Relevant External Links for VEZF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VEZF1

No disorders were found for VEZF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for VEZF1 Gene

Publications for VEZF1 Gene

  1. Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter. (PMID: 8035792) Koyano-Nakagawa N. … Yokota T. (Mol. Cell. Biol. 1994) 2 3 4 22 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. (PMID: 22308494) Gowher H. … Felsenfeld G. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 64
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64

Products for VEZF1 Gene

Sources for VEZF1 Gene

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