VEZF1 Gene
protein-coding GIFtS: 45
GCID: GC17M056048
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vascular endothelial zinc finger 1(Previous name: zinc finger protein 161 )
(Previous symbol: ZNF161)
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Aliases
for VEZF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Vascular Endothelial Zinc Finger 11 2 | | ZNF1611 2 3 5 | | Zinc Finger Protein 1611 2 3 | | DB11 2 3 | | Putative Transcription Factor DB12 3 |
Export aliases for VEZF1 gene to outside databasesPrevious GC identifers: GC17M053403 GC17M051410 |
Summaries
for VEZF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VEZF1:
Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in bothnormal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein(Koyano-Nakagawa et al., 1994 (PubMed 8035792)). See MIM 603971 for general information on zinc fingerproteins.(supplied by OMIM, Sep 2008)
UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119Function: Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter andmediates tax transactivation of IL-3
|
Genomic Views
for VEZF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VEZF1 gene promoter:
NRSF form 1 AP-2gamma Evi-1 AREB6 POU2F1 AP-2beta AP-2alpha MRF-2 Ik-1 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for VEZF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEZF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q22VEZF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M056048: view genomic region
(about GC identifiers)
Start:
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56,048,910 bp from pter |
End:
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56,065,620 bp from pter |
Size:
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16,711 bases |
Orientation:
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minus strand |
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Proteins
for VEZF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119 (See
protein sequence)Recommended Name: Vascular endothelial zinc finger 1 Size: 521 amino acids; 56931 Da
Subunit: Interacts with ARHGAP22 (By similarity)
Subcellular location: NucleusExplore the universe of human proteins at neXtProt for VEZF1: NX_Q14119
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14119
VEZF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009077.2
ENSEMBL proteins: ENSP00000258963 ENSP00000464687 ENSP00000462337 ENSP00000463631
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
VEZF1 for ontologies About GeneDecksing
VEZF1 Antibody Products:
Assay Products for VEZF1: |
Protein
Domains /
Families
for VEZF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VEZF1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14119ProtoNet protein and cluster: Q14119 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 6 C2H2-type zinc fingers |
Function
for VEZF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119Function: Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter andmediates tax transactivation of IL-3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEZF1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEZF1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEZF1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
VEZF1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for VEZF1:
Animal Models:
Mouse knock-out Vezf1tm1Stmn for VEZF1
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Vezf1):
VEZF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for VEZF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VEZF1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for VEZF1 (ENSP000002589634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
VEZF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for VEZF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for VEZF1
Search CenterWatch for drugs/clinical trials and news about VEZF1
|
Transcripts
for VEZF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for VEZF1 gene: NM_007146.2 Unigene Cluster for VEZF1: Vascular endothelial zinc finger 1 Hs.463569 [show with all ESTs]Unigene Representative Sequence: NM_0071464 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000258963(uc002ivf.1) ENST00000584396 ENST00000581208(uc010dcn.1)
ENST00000583932
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEZF1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEZF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: VEZF1 (NM_007146) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for VEZF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEZF1 |
Additional cDNA sequence: AB593183.1 AK058024.1 BX648862.1 D28118.1 11 DOTS entries: DT.100793587 DT.92431525 DT.95188994 DT.100793576 DT.100793579 DT.120850471 DT.120937961 DT.75188496 DT.92431527 DT.99936620 DT.40294655 24/298 AceView cDNA sequences (see all 298): BM676135 AW183892 BM977996 T92348 AA227945 AI208612 CB305814 AA973711 BG149947 AA731648 BM873386 F36220 AW079327 AI202735 H87224 BU620853 BI966844 AI191493 CB529650 AI073705 BF590384 AI090020 AI052492 BI769650
GeneLoc Exon Structure
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Expression
for VEZF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| VEZF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See VEZF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for VEZF1
SOURCE GeneReport for Unigene cluster: Hs.463569
UniProtKB/Swiss-Prot: VEZF1_HUMAN, Q14119Tissue specificity: Ubiquitously expressed. Highest levels in skeletal muscle and kidney
SABiosciences Custom PCR Arrays for VEZF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VEZF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VEZF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VEZF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEZF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEZF1 |
Orthologs
for VEZF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for VEZF1 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for VEZF1 (if available)
TreeFam Gene Tree for VEZF1 (if available) |
Paralogs
for VEZF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for VEZF1 gene
- MAZ2 PATZ12
18/56 SIMAP similar genes for VEZF1 using alignment to 4 protein entries: VEZF1_HUMAN (see all proteins)
(see all similar genes):A-328A3.4 MAZ DKFZp686N0199 ZNF219 KLF1 KLF7
ZNF55 ZNF78L1 KLF13 ZNF516 ZNF263 GZF1
ZNF kr-znf3 ZNF138 DKFZp434J0650 DKFZp313M0722 DKFZp686O1631
VEZF1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for VEZF1
PGOHUM00000237903
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Genomic Variants
for VEZF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for VEZF1 (56048910 - 56065620 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VEZF1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VEZF1 |
|
Disorders
/ Diseases
for VEZF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VEZF1 for disorders About GeneDecksing
OMIM gene information: 606747
OMIM disorders: --
2  diseases for VEZF1: About MalaCardslymphangioma cystic lymphangioma
Export disorders for VEZF1 gene to outside databases
|
Publications
for VEZF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for VEZF1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with VEZF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter. (PubMed id 8035792)1, 2, 3, 9 Koyano-Nakagawa N.... Yokota T. (1994)
- Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. (PubMed id 22308494)1 Gowher H....Felsenfeld G. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PubMed id 16335786)1 Lin J.... Wigle J.T. (2005)
- Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter. (PubMed id 11504723)1 Aitsebaomo J....Patterson C. (2001)
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External Searches for VEZF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing VEZF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VEZF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VEZF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for VEZF1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for VEZF1 gene:
Search GeneIP for patents involving VEZF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VEZF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for VEZF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for VEZF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for VEZF1 | | | OriGene Protein Over-expression Lysate for VEZF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for VEZF1 | | OriGene 3'-UTR Clone for VEZF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for VEZF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for VEZF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for VEZF1 | | OriGene Custom Protein Services for VEZF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat VEZF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing VEZF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEZF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEZF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEZF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VEZF1 |
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| | | | Search Tocris compounds for VEZF1 |
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 | | | VEZF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEZF1 |
|  |  |  | | | | Search ThermoFisher Antibodies for VEZF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEZF1 |
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