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Aliases for VEPH1 Gene

Aliases for VEPH1 Gene

  • Ventricular Zone Expressed PH Domain-Containing 1 2 3
  • Protein Melted 3 4
  • KIAA1692 4 6
  • MELT 3 6
  • VEPH 3 4
  • Ventricular Zone-Expressed PH Domain-Containing Protein Homolog 1 3
  • Ventricular Zone Expressed PH Domain Homolog 1 (Zebrafish) 2
  • Ventricular Zone Expressed PH Domain Homolog 1 3

External Ids for VEPH1 Gene

Previous GeneCards Identifiers for VEPH1 Gene

  • GC03M158461
  • GC03M156977
  • GC03M154373

Summaries for VEPH1 Gene

GeneCards Summary for VEPH1 Gene

VEPH1 (Ventricular Zone Expressed PH Domain-Containing 1) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VEPH1 Gene

Genomics for VEPH1 Gene

Regulatory Elements for VEPH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for VEPH1 Gene

Start:
157,259,742 bp from pter
End:
157,533,619 bp from pter
Size:
273,878 bases
Orientation:
Minus strand

Genomic View for VEPH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VEPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VEPH1 Gene

Proteins for VEPH1 Gene

  • Protein details for VEPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14D04-MELT_HUMAN
    Recommended name:
    Ventricular zone-expressed PH domain-containing protein homolog 1
    Protein Accession:
    Q14D04
    Secondary Accessions:
    • D3DNL0
    • F5GZ91
    • Q2TAA9
    • Q3MIX2
    • Q6PEL3
    • Q86TL5
    • Q8TCR3
    • Q96SP7
    • Q9C0H1
    • Q9H9Q7

    Protein attributes for VEPH1 Gene

    Size:
    833 amino acids
    Molecular mass:
    94745 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14165.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21783.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for VEPH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for VEPH1 Gene

Proteomics data for VEPH1 Gene at MOPED

Post-translational modifications for VEPH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for VEPH1 Gene

Domains for VEPH1 Gene

Gene Families for VEPH1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for VEPH1 Gene

Suggested Antigen Peptide Sequences for VEPH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14D04

UniProtKB/Swiss-Prot:

MELT_HUMAN :
  • Q14D04
Domain:
  • The PH domain is required for membrane targeting.
  • Contains 1 PH domain.
Family:
  • Belongs to the MELT/VEPH family.
genes like me logo Genes that share domains with VEPH1: view

Function for VEPH1 Gene

Gene Ontology (GO) - Molecular Function for VEPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with VEPH1: view

Phenotypes for VEPH1 Gene

MGI mutant phenotypes for VEPH1:
inferred from 1 alleles
GenomeRNAi human phenotypes for VEPH1:
genes like me logo Genes that share phenotypes with VEPH1: view

Animal Models for VEPH1 Gene

MGI Knock Outs for VEPH1:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for VEPH1 Gene

Localization for VEPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VEPH1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VEPH1 Gene COMPARTMENTS Subcellular localization image for VEPH1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for VEPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with VEPH1: view

Pathways for VEPH1 Gene

SuperPathways for VEPH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for VEPH1 Gene

None

No data available for Pathways by source for VEPH1 Gene

Transcripts for VEPH1 Gene

Unigene Clusters for VEPH1 Gene

Ventricular zone expressed PH domain-containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for VEPH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VEPH1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5:
SP6:
SP7: -

Relevant External Links for VEPH1 Gene

GeneLoc Exon Structure for
VEPH1
ECgene alternative splicing isoforms for
VEPH1

Expression for VEPH1 Gene

mRNA expression in normal human tissues for VEPH1 Gene

mRNA differential expression in normal tissues according to GTEx for VEPH1 Gene

This gene is overexpressed in Adrenal Gland (10.5), Pituitary (10.3), Lung (8.0), and Kidney - Cortex (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for VEPH1 Gene

SOURCE GeneReport for Unigene cluster for VEPH1 Gene Hs.658046

genes like me logo Genes that share expressions with VEPH1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for VEPH1 Gene

Orthologs for VEPH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for VEPH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VEPH1 35
  • 99.56 (n)
  • 99.4 (a)
VEPH1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VEPH1 35
  • 90.28 (n)
  • 90.4 (a)
VEPH1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VEPH1 35
  • 87.43 (n)
  • 86.31 (a)
VEPH1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Veph1 35
  • 85.15 (n)
  • 85.47 (a)
Veph1 16
Veph1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia VEPH1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Veph1 35
  • 84.25 (n)
  • 85.94 (a)
chicken
(Gallus gallus)
Aves VEPH1 35
  • 73.56 (n)
  • 74.4 (a)
VEPH1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VEPH1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia veph1 35
  • 66.99 (n)
  • 64.56 (a)
zebrafish
(Danio rerio)
Actinopterygii veph 35
  • 62.63 (n)
  • 62.42 (a)
veph 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007472 35
  • 48.1 (n)
  • 38.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta melt 35
  • 48.29 (n)
  • 41.28 (a)
melt 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K10B4.3 35
  • 45.33 (n)
  • 34.63 (a)
K10B4.3 36
  • 26 (a)
OneToOne
Species with no ortholog for VEPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VEPH1 Gene

ENSEMBL:
Gene Tree for VEPH1 (if available)
TreeFam:
Gene Tree for VEPH1 (if available)

Paralogs for VEPH1 Gene

No data available for Paralogs for VEPH1 Gene

Variants for VEPH1 Gene

Sequence variations from dbSNP and Humsavar for VEPH1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs722484 -- 157,382,838(+) TATTT(C/T)AGTAT intron-variant
rs722485 -- 157,383,049(+) CCCAG(C/G)CTGGC intron-variant
rs724960 -- 157,398,927(-) AAGTA(A/T)TGTTT intron-variant
rs894643 -- 157,503,539(-) TTGCG(C/T)CAATT upstream-variant-2KB, utr-variant-5-prime
rs920759 -- 157,502,931(-) TTTAC(C/T)TCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for VEPH1 Gene

Variant ID Type Subtype PubMed ID
nsv829766 CNV Gain 17160897
nsv877687 CNV Loss 21882294
esv274040 CNV Insertion 20981092
esv270978 CNV Insertion 20981092
esv275099 CNV Gain+Loss 21479260
esv2582112 CNV Deletion 19546169
dgv1525e1 CNV Complex 17122850
nsv236425 CNV Insertion 16902084
esv32988 CNV Loss 17666407

Relevant External Links for VEPH1 Gene

HapMap Linkage Disequilibrium report
VEPH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for VEPH1 Gene

Disorders for VEPH1 Gene

Relevant External Links for VEPH1

Genetic Association Database (GAD)
VEPH1
Human Genome Epidemiology (HuGE) Navigator
VEPH1
genes like me logo Genes that share disorders with VEPH1: view

No data available for UniProtKB/Swiss-Prot for VEPH1 Gene

Publications for VEPH1 Gene

  1. Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. (PMID: 15388229) Muto E. … Watanabe S. (Biochimie 2004) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for VEPH1 Gene

Sources for VEPH1 Gene

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