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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

VEPH1 Gene

protein-coding   GIFtS: 47
GCID: GC03M156977

Ventricular Zone Expressed PH Domain-Containing 1

(Previous name: ventricular zone expressed PH domain homolog 1 (zebrafish))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ventricular Zone Expressed PH Domain-Containing 11 2     KIAA16923 5
Protein Melted2 3     Ventricular Zone Expressed PH Domain Homolog 1 (Zebrafish)1
VEPH2 3     Ventricular Zone Expressed PH Domain Homolog 12
MELT2 5     Ventricular Zone-Expressed PH Domain-Containing Protein Homolog 12

External Ids:    HGNC: 257351   Entrez Gene: 796742   Ensembl: ENSG000001974157   OMIM: 6095945   UniProtKB: Q14D043   

Export aliases for VEPH1 gene to outside databases

Previous GC identifers: GC03M158461 GC03M154373


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for VEPH1 Gene: 
VEPH1 (ventricular zone expressed PH domain-containing 1) is a protein-coding gene. Diseases associated with VEPH1 include hepatitis b, and hepatitis. GO annotations related to this gene include phospholipid binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VEPH1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   LHX3b/Lhx3b   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): VEPH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for VEPH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat VEPH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24-q25   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q24-q25

VEPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VEPH1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M156977:  view genomic region     (about GC identifiers)

Start:
156,977,531 bp from pter      End:
157,251,408 bp from pter
Size:
273,878 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MELT_HUMAN, Q14D04 (See protein sequence)
Recommended Name: Ventricular zone-expressed PH domain-containing protein homolog 1  
Size: 833 amino acids; 94745 Da
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
Sequence caution: Sequence=BAB14165.1; Type=Erroneous initiation; Sequence=BAB21783.1; Type=Erroneous initiation;
Secondary accessions: D3DNL0 F5GZ91 Q2TAA9 Q3MIX2 Q6PEL3 Q86TL5 Q8TCR3 Q96SP7 Q9C0H1 Q9H9Q7
Alternative splicing: 4 isoforms:  Q14D04-1   Q14D04-2   Q14D04-3   Q14D04-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for VEPH1: NX_Q14D04

Explore proteomics data for VEPH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14D04

  • VEPH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    VEPH1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001161383.1  NP_001161384.1  NP_001161387.1  NP_001161388.1  NP_001161389.1  NP_078897.2  

    ENSEMBL proteins: 
     ENSP00000376578   ENSP00000354919   ENSP00000376577   ENSP00000418963   ENSP00000419193  
     ENSP00000417268   ENSP00000420097   ENSP00000418175   ENSP00000417700   ENSP00000417157  
     ENSP00000417298   ENSP00000446258   ENSP00000443868  

    Human Recombinant Protein Products for VEPH1: 
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    OriGene Protein Over-expression Lysate for VEPH1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for VEPH1
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    Novus Biologicals VEPH1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for VEPH1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--

    VEPH1 for ontologies           About GeneDecksing



    VEPH1 Antibody Products: 
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    Search LSBio for Antibodies for VEPH1 

    Assay Products for VEPH1: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for VEPH1 
    Cloud-Clone Corp. CLIAs for VEPH1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q14D04

    ProtoNet protein and cluster: Q14D04

    UniProtKB/Swiss-Prot: MELT_HUMAN, Q14D04
    Domain: The PH domain is required for membrane targeting (By similarity)
    Similarity: Belongs to the MELT/VEPH family
    Similarity: Contains 1 PH domain


    VEPH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    VEPH1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for VEPH1:
     Decreased Wnt reporter activit 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Veph1):
     normal 

    VEPH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Veph1tm1Wtnb for VEPH1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for VEPH1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for VEPH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for VEPH1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for VEPH1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEPH1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate VEPH1:
    hsa-miR-3200-5p hsa-miR-607 hsa-miR-767-3p hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidVEPH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VEPH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEPH1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for VEPH1
    Sirion Biotech Customized adenovirus for overexpression of VEPH1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for VEPH1 (see all 23)
    OriGene ORF clones in mouse, rat for VEPH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): VEPH1 (NM_024621)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEPH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEPH1
    Sirion Biotech Customized lentivirus for stable overexpression of VEPH1 
                         Customized lentivirus expression plasmids for stable overexpression of VEPH1 

    Cell Line
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    Search LifeMap BioReagents cell lines for VEPH1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEPH1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VEPH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/13 Interacting proteins for VEPH1 (Q14D043 ENSP000003549194) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    TGFBR1P368973, ENSP000003641334I2D: score=2 STRING: ENSP00000364133
    SMAD1Q157973, ENSP000003057694I2D: score=2 STRING: ENSP00000305769
    BMPR1BO002383, ENSP000002645684I2D: score=2 STRING: ENSP00000264568
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VEPH1 (MELT)

    Search CenterWatch for drugs/clinical trials and news about VEPH1 / MELT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for VEPH1 gene (6 alternative transcripts): 
    NM_001167911.1  NM_001167912.1  NM_001167915.1  NM_001167916.1  NM_001167917.1  NM_024621.2  

    Unigene Cluster for VEPH1:

    Ventricular zone expressed PH domain-containing 1
    Hs.658046  [show with all ESTs]
    Unigene Representative Sequence: NM_024621
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000392833 ENST00000362010(uc003fbk.2 uc010hvu.2) ENST00000392832
    ENST00000472419 ENST00000488772 ENST00000482685 ENST00000469007 ENST00000479987
    ENST00000494677(uc003fbn.3) ENST00000490235 ENST00000468233(uc003fbm.3)
    ENST00000482434 ENST00000487753 ENST00000473907 ENST00000475050 ENST00000461299
    ENST00000489602 ENST00000483440
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat VEPH1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate VEPH1:
    hsa-miR-3200-5p hsa-miR-607 hsa-miR-767-3p hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidVEPH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for VEPH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat VEPH1
    Clone
    Products:
         
    OriGene clones in human, mouse for VEPH1 (see all 23)
    OriGene ORF clones in mouse, rat for VEPH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): VEPH1 (NM_024621)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for VEPH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat VEPH1
    Sirion Biotech Customized lentivirus for stable overexpression of VEPH1 
                         Customized lentivirus expression plasmids for stable overexpression of VEPH1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for VEPH1
    OriGene qSTAR qPCR primer pairs in human, mouse for VEPH1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat VEPH1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VEPH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEPH1

    Additional mRNA sequence: 

    AB051479.1 AK022666.1 AK027625.1 AL713656.1 BC026235.1 BC042159.1 BC057999.1 BC078142.1 
    BC101660.1 BC111017.1 BC113555.1 

    14 DOTS entries:

    DT.100019893  DT.91743516  DT.210958  DT.86840814  DT.120868141  DT.92037020  DT.100686399  DT.120868181 
    DT.40119289  DT.91743511  DT.91743515  DT.91743517  DT.97788622  DT.100777112 

    24/115 AceView cDNA sequences (see all 115):

    AA917969 AW955316 AA359252 NM_024621 AW779807 BQ015118 AA913641 CA431070 
    CA443570 BP364403 BM083616 AI277666 AI740705 AI168722 BU631955 BC078142 
    BC042159 BC057999 W81237 BX419174 AK027625 BE048751 AI283485 AW236094 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VEPH1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                    -     -           -     -                             -                                                               
    SP2:                                      -     -                             -                                                               
    SP3:              -                       -     -                                                                                             
    SP4:              -     -     -           -     -                                                                                             
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for VEPH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    VEPH1 expression in normal human tissues (normalized intensities)      VEPH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATCTTGGA
    VEPH1 Expression
    About this image


    VEPH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)
             BONE MARROW   
     
     Melanocytes (Integumentary System)
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Chorion (Extraembryonic Tissues)
             chorion villus cells   
     
     Ovary (Reproductive System)
             oocyte   
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...

    See VEPH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for VEPH1

    SOURCE GeneReport for Unigene cluster: Hs.658046
        SABiosciences Custom PCR Arrays for VEPH1
    Primer
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    OriGene qPCR primer pairs and template standards for VEPH1
    OriGene qSTAR qPCR primer pairs in human, mouse for VEPH1
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat VEPH1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat VEPH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for VEPH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for VEPH1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Veph11 , 5 ventricular zone expressed PH domain homolog 1 (zebrafish)1, 5 85.15(n)1
    85.47(a)1
      3 (30.25 cM)5
    727891  NM_145820.21  NP_665819.21 
     660535585 
    chicken
    (Gallus gallus)
    Aves VEPH11 ventricular zone expressed PH domain homolog 1 (zebrafish) 73.56(n)
    74.4(a)
      100859365  XM_003641782.1  XP_003641830.1 
    lizard
    (Anolis carolinensis)
    Reptilia VEPH16
    ventricular zone expressed PH domain-containing 1
    72(a)
    1 ↔ 1
    3(14827969-14986402)
    zebrafish
    (Danio rerio)
    Actinopterygii veph1 ventricular zone expressed PH domain protein 62.63(n)
    62.42(a)
      405756  NM_212831.1  NP_997996.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta melt1 melted 48.29(n)
    41.28(a)
      38785  NM_079229.3  NP_523953.2 
    worm
    (Caenorhabditis elegans)
    Secernentea K10B4.31 Protein K10B4.3 42.61(n)
    30.98(a)
      173397  NM_061263.2  NP_493664.2 


    ENSEMBL Gene Tree for VEPH1 (if available)
    TreeFam Gene Tree for VEPH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4517 SNPs in VEPH1 are shown (see all 4517)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836658011,2
    --156977071(+) CATTGC/TTTCTC 3 -- ds50010--------
    rs1162694281,2
    F--156977178(+) TTATTC/TTCTCT 3 -- ds50011Minor allele frequency- T:0.06WA 118
    rs130845221,2
    C,F,H--156977207(+) TTGCAT/CCTTTG 3 -- ds500123Minor allele frequency- C:0.43NA EA NS WA 2706
    rs738736171,2
    C,F--156977642(+) CAAGGC/TGTTGG 3 -- ut311Minor allele frequency- T:0.50WA 2
    rs1440020191,2
    --156977902(+) TTCACA/TTTTGT 3 -- ut310--------
    rs1461390401,2
    --156978000(+) ACTCAA/GTGGGG 3 -- ut310--------
    rs10469381,2
    C,F,A,H--156978173(+) TTTAAC/TGGAGA 3 -- ut3122Minor allele frequency- T:0.49MN NS EA NA WA CSA 2528
    rs1895386101,2
    --156978185(+) GGCACA/GTTATT 3 -- ut310--------
    rs1820043421,2
    --156978257(+) GATATA/GTGTCC 3 -- ut310--------
    rs1401863981,2
    C--156978330(+) GAAAGA/GCAAGT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for VEPH1 (156977531 - 157227531 bp, first 250kb of VEPH1)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for VEPH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2582112CNV Deletion19546169
    esv274040CNV Insertion20981092
    nsv236425CNV Insertion16902084
    esv270978CNV Insertion20981092
    nsv877687CNV Loss21882294
    esv32988CNV Loss17666407
    nsv829766CNV Gain17160897
    esv275099CNV Gain+Loss21479260
    dgv1525e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609594    OMIM disorders: --

    2 diseases for VEPH1:    About MalaCards
    hepatitis b    hepatitis


    VEPH1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): VEPH1
    Human Genome Epidemiology (HuGE) Navigator: VEPH1 (5 documents)

    Export disorders for VEPH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for VEPH1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with VEPH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. (PubMed id 15388229)1, 2, 3 Muto E.... Watanabe S. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (2011)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    10. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)4 O'Donnell C.J....Demissie S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79674 HGNC: 25735 AceView: FLJ12604 Ensembl:ENSG00000197415 euGenes: HUgn79674
    ECgene: VEPH1 H-InvDB: VEPH1

    (According to HUGE)
    About This Section
    HUGE: KIAA1692

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for VEPH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for VEPH1 gene:
    Search GeneIP for patents involving VEPH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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