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Aliases & Descriptions for VEPH1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ12604 1, 2 | | KIAA1692 1, 2, 3, 5 | | MELT 2, 5 | | MGC111426 2 | | MGC126709 2 | | MGC142115 2 | | VEPH 3 |
| | | Descriptions |
|---|
| Protein melted 3 | | ventricular zone expressed PH domain homolog 1 2 | | ventricular zone expressed PH domain homolog 1 (zebrafish) 2 |
|
| | Search outside databases for aliases for VEPH1 gene |
Summaries for VEPH1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for VEPH1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the VEPH1 gene 
Entrez Gene cytogenetic band: 3q24-q25 Ensembl cytogenetic band: 3q25.32 HGNC cytogenetic band: 3q24-q25VEPH1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M158461:
(about GC identifiers)
Start:
|
158,460,228 bp from pter |
End:
|
158,703,830 bp from pter |
Size:
|
243,603 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_005612.15
| Proteins for VEPH1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MELT_HUMAN, Q14D04 (See
protein sequence)Recommended Name: Ventricular zone-expressed PH domain-containing protein homolog 1 Size: 833 amino acids; 94745 Da
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
Secondary accessions: Q2TAA9 Q3MIX2 Q6PEL3 Q86TL5 Q8TCR3 Q96SP7 Q9C0H1 Q9H9Q7Alternative splicing: 3 isoforms: Q14D04-1 Q14D04-2 Q14D04-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_078897.1
ENSEMBL proteins: ENSP00000354919 ENSP00000376578 ENSP00000376577
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: VEPH1 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for VEPH1: Assays for VEPH1: | Protein
Domains/ Families for VEPH1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q14D04
ProtoNet protein and cluster: Q14D04 UniProtKB/Swiss-Prot: MELT_HUMAN, Q14D04Domain: The PH domain is required for membrane targeting (By similarity)Similarity: Belongs to the MELT/VEPH familySimilarity: Contains 1 PH domain | Gene Function for VEPH1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024621
Applied Biosystems Silencer® siRNAs for VEPH1
Sigma-Aldrich siRNA for VEPH1  Sigma-Aldrich shRNA for VEPH1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024621                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024621                                  untagged cDNA clone in CMV expression vector: NM_024621 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024621
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Veph1):
| Pathways & Interactions for VEPH1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| -- |
Drugs & Compounds for VEPH1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for VEPH1
|
Transcripts for VEPH1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024621
Sigma-Aldrich siRNA for VEPH1  Sigma-Aldrich shRNA for VEPH1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_024621 REFSEQ mRNAs for VEPH1 gene: NM_024621.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024621               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024621                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024621                                  untagged cDNA clone in CMV expression vector: NM_024621  Additional cDNA sequence: AB051479.1 AK022666.1 AK027625.1 AK312705.1 AL713656.1 BC026235.1 BC042159.1 BC057999.1 BC078142.1 BC101660.1 BC111017.1 BC113555.1 14 DOTS entries: DT.100019893 DT.91743516 DT.210958 DT.120868141 DT.86840814 DT.92037020 DT.100686399 DT.120868181 DT.40119289 DT.91743511 DT.91743515 DT.91743517 DT.97788622 DT.100777112 24/115 AceView cDNA sequences (see all 115
):BU631955 BC042159 BX419174 AI740705 BE048751 CA443570 AI283485 BQ015118 W81274 AA913641 BC078142 AK027625 AA359252 AW955316 CA431070 NM_024621 AI277666 AW779807 AA917969 BM083616 AW236094 BP364403 AI168722 BC057999
highest scoring ESTs for VEPH1:AA256444 AB051479 AI635944 AK027625 BI824829 AA143130 AA359252 AA613875 AA644658 AA775321 Unigene Cluster for VEPH1: Ventricular zone expressed PH domain homolog 1 (zebrafish) Hs.658046 [show with all ESTs]Unigene Representative Sequence: AB051479
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VEPH1 (see all 7
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | |
| SP1: | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for VEPH1
3 Ensembl transcripts including schematic representations: ENST00000362010
ENST00000392833
ENST00000392832
|
Expression for VEPH1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| VEPH1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for VEPH1
1 / 2 / 3 9 probe-sets matching VEPH1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.658046
|
Orthologs for VEPH1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VEPH1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for VEPH1
ENSEMBL Gene Tree for VEPH1 | Paralogs for VEPH1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for VEPH1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for VEPH1 (up to first 250kb)
|
Disorders & Mutations for VEPH1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609594
|
Medical News for VEPH1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for VEPH1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for VEPH1 gene:- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)2, 3, 4 Nagase T....Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)4 Olsen J.V....Mann M. (2006)
- Drosophila Melted modulates FOXO and TOR activity. (PubMed id 16054033)4 Teleman A.A.... Cohen S.M. (2005)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)3 Barrios-Rodiles M....Wrana J.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. (PubMed id 15388229)4 Muto E.... Watanabe S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for VEPH1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing VEPH1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing VEPH1
(According to HUGE)
About This Section
| |
Specialized Databases showing VEPH1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for VEPH1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for VEPH1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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