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VEPH1 Gene

protein-coding   GIFtS: 44

GC03M158461
ventricular zone expressed PH domain homolog 1 (zebrafish)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ12604 1, 2
KIAA1692 1, 2, 3, 5
MELT 2, 5
MGC111426 2
MGC126709 2
MGC142115 2
VEPH 3
Descriptions
Protein melted 3
ventricular zone expressed PH domain homolog 1 2
ventricular zone expressed PH domain homolog 1 (zebrafish) 2
External Ids
HGNC: 257351
Entrez Gene: 796742
UniProtKB: Q14D043
Ensembl: ENSG000001974157
Search outside databases for aliases for VEPH1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the VEPH1 gene  

Entrez Gene cytogenetic band: 3q24-q25   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q24-q25

VEPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M158461:     (about GC identifiers)

Start:
158,460,228 bp from pter
End:
158,703,830 bp from pter
Size:
243,603 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MELT_HUMAN, Q14D04 (See protein sequence)
Recommended Name: Ventricular zone-expressed PH domain-containing protein homolog 1  
Size: 833 amino acids; 94745 Da
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
Secondary accessions: Q2TAA9 Q3MIX2 Q6PEL3 Q86TL5 Q8TCR3 Q96SP7 Q9C0H1 Q9H9Q7
Alternative splicing: 3 isoforms:  Q14D04-1   Q14D04-2   Q14D04-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_078897.1  

    ENSEMBL proteins: 
    ENSP00000354919 ENSP00000376578 ENSP00000376577 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: VEPH1 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for VEPH1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for VEPH1
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for VEPH1

    Assays for VEPH1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_type


       GeneDecks  VEPH1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q14D04

    ProtoNet protein and cluster: Q14D04

    UniProtKB/Swiss-Prot: MELT_HUMAN, Q14D04
    Domain: The PH domain is required for membrane targeting (By similarity)
    Similarity: Belongs to the MELT/VEPH family
    Similarity: Contains 1 PH domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VEPH1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024621

                  Applied Biosystems Silencer® siRNAs for VEPH1

                  Sigma-Aldrich siRNA for VEPH1  
                         Sigma-Aldrich shRNA for VEPH1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_024621
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_024621
                                     untagged cDNA clone in CMV expression vector: NM_024621 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_024621

    1 MGI mutant phenotype (inferred from 1 allele(MGI details for Veph1):

    normal

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for VEPH1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (VEPH1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024621

                  Sigma-Aldrich siRNA for VEPH1  
                         Sigma-Aldrich shRNA for VEPH1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_024621  

    REFSEQ mRNAs for VEPH1 gene: 

    NM_024621.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_024621  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_024621
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_024621
                                     untagged cDNA clone in CMV expression vector: NM_024621 

    Additional cDNA sequence: 

    AB051479.1 AK022666.1 AK027625.1 AK312705.1 AL713656.1 BC026235.1 BC042159.1 BC057999.1 
    BC078142.1 BC101660.1 BC111017.1 BC113555.1 

    14 DOTS entries:

    DT.100019893  DT.91743516  DT.210958  DT.120868141  DT.86840814  DT.92037020  DT.100686399  DT.120868181 
    DT.40119289  DT.91743511  DT.91743515  DT.91743517  DT.97788622  DT.100777112 

    24/115 AceView cDNA sequences (see all 115 ):

    BU631955 BC042159 BX419174 AI740705 BE048751 CA443570 AI283485 BQ015118 
    W81274 AA913641 BC078142 AK027625 AA359252 AW955316 CA431070 NM_024621 
    AI277666 AW779807 AA917969 BM083616 AW236094 BP364403 AI168722 BC057999 

    highest scoring ESTs for VEPH1:

    AA256444 AB051479 AI635944 AK027625 BI824829 AA143130 AA359252 AA613875 AA644658 AA775321 

    Unigene Cluster for VEPH1:

    Ventricular zone expressed PH domain homolog 1 (zebrafish)
    Hs.658046  [show with all ESTs]
    Unigene Representative Sequence: AB051479


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VEPH1 (see all 7 )

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                    -     -           -     -                             -                                                               
    SP2:                                      -     -                             -                                                               
    SP3:              -                       -     -                                                                                             
    SP4:              -     -     -           -     -                                                                                             
    SP5:                                                                                                                                          

    About this scheme

    ECgene alternative splicing isoforms for VEPH1

    3 Ensembl transcripts including schematic representations:
    ENST00000362010  ENST00000392833  ENST00000392832  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    VEPH1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for VEPH1

    1 / 2 / 3

    9 probe-sets matching VEPH1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    61696_at2, 3 U95-C 1 1.00 1.00 0.95 1.27 AA256444 0.80 1.00 0.91 1
    59502_at2, 3 U95-C 1 1.00 1.00 0.87 0.97 AI950109 0.60 1.00 0.82 1

    85508_at2, 3 U95-E 1 0.94 1.00 0.92 0.82 AI635944 0.80 1.00 0.91 1

    232122_s_at2, 3 U133-B 1 1.00 1.00 -- -- AK022666 0.60 1.00 0.82 1

    229759_s_at2, 3 U133-B 1 1.00 1.00 -- -- AA988323 0.40 1.00 0.76 1

    229760_at2, 3 U133-B 1 0.64 1.00 -- -- AA988323 0.40 1.00 0.76 1

    232122_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    229759_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    229760_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    GeneDecks  VEPH1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.658046
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for VEPH1 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    VEPH11   -- ventricular zone expressed PH domain homolog 1 (zebrafish) 87.35(n)
    86.19(a)
    485731  XM_542853.2  XP_542853.2 
    chimpanzee
    (Pan troglodytes)
    VEPH11   -- ventricular zone expressed PH domain homolog 1 (zebrafish) 99.48(n)
    99.16(a)
    460808  XM_001153071.1  XP_001153071.1 
    cow
    (Bos taurus)
    VEPH11   -- ventricular zone expressed PH domain homolog 1 (zebrafish) 86.7(n)
    82.54(a)
    537834  XM_618021.3  XP_618021.3 
    rat
    (Rattus norvegicus)
    Veph11   -- ventricular zone expressed PH domain homolog 1 (zebrafish) 84.17(n)
    85.7(a)
    361954  NM_001014171.1  NP_001014193.1 
    mouse
    (Mus musculus)
    Veph11, 5 35
    ventricular zone expressed PH domain homolog 1 (zebrafish)1, 5 85.03(n)1
    85.35(a)1
    727891  NM_145820.11  NP_665819.11 
     AB0851875  AB0851895  (see all 10)
    About this table        Species with no ortholog for VEPH1

    ENSEMBL Gene Tree for VEPH1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1282 NCBI SNPs in VEPH1 are shown (see all 1282 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 436)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs98510661,2
    A,C,F,H158701430(+) tgggaG/Cgttta 1 -- ng314Minor allele frequency- C:0.19EU EA WA 408
    rs13787961,2
    A,C,F,H158614482(+) CATAGA/CCTGCT 1 V/G mis116Minor allele frequency- C:0.22EU EA WA NA 2186
    rs13787951,2
    A,C,F,H158614459(+) AAAACT/AGTTCA 1 C/S mis112Minor allele frequency- A:0.02NA EU EA WA 1028
    rs119189741,2
    A,C,F,H158564018(+) TTCTGA/GCAAAT 1 S/P mis113Minor allele frequency- G:0.26EA NA EU WA 1116
    rs10605431,2
    A,C,F,H158461370(-) AGCTAC/GAGAGT 1 -- ng51 ese35Minor allele frequency- G:0.46MN EU EA WA 596
    rs13787941,2
    A,C,F,O158700584(-) CACGTG/AGATTT 1 -- ng313Minor allele frequency- A:0.17NA 142
    rs105135151,2
    C,F,H158701927(+) TTCCAT/CGGAAG 1 -- ng3112Minor allele frequency- C:0.13NS EU EA WA NA 642
    rs119233801,2
    C,F,H158581811(+) CTCCAT/CGTTGG 1 V/M mis1 ese38Minor allele frequency- C:0.01EU EA WA 838
    rs168275631,2
    C,F,H158581672(+) GTTGTC/TGGGTA 1 R/Q mis1 ese315Minor allele frequency- T:0.04NA EU EA WA 1400
    rs168277391,2
    C,F,H158695867(+) CTACAG/TACCCA 1 -- ut51 ese37Minor allele frequency- T:0.02NA EU EA WA 562
    About this table

    HapMap Linkage Disequilibrium images for VEPH1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 609594

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for VEPH1 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 79674 HGNC: 25735 AceView: FLJ12604 Ensembl:ENSG00000197415 euGenes: HUgn79674
    ECgene: VEPH1 H-InvDB: VEPH1
    (According to HUGE)
    About This Section

    HUGE: KIAA1692
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for VEPH1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for VEPH1-related products

     Millipore Custom Antibody & Bulk Services
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     Predesigned and custom siRNAs for VEPH1 Antibodies for VEPH1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for VEPH1 Browse small molecules at Sigma-Aldrich
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     Search Tocris compounds for VEPH1




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     Search Novus for antibodies for VEPH1

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